Patent Description:
Plasma, which uses an effect of excited electrons, has been applied in various ways to fields of electricity, chemistry, materials, and medical care. A technology has been reported that, as application of plasma to medical care, a solution manufactured through plasma irradiation has an effect of killing a tumor (PTL <NUM>). Further related background art is disclosed in PTL <NUM> to PTL <NUM>.

The effect of an aqueous solution having antitumor properties (hereinafter, referred to as "antitumor aqueous solution") that is generated through plasma irradiation varies in accordance with conditions such as a plasma irradiation time, and appropriate plasma irradiation conditions depend on the type of tumor.

With the plasma irradiation device of the related art, it is difficult to determine whether an appropriate antitumor effect is attained and it is difficult to select appropriate plasma irradiation conditions.

The invention is made in light of the situations, and a problem to be addressed is to provide an antitumor aqueous solution manufacturing device capable of manufacturing an antitumor aqueous solution having an appropriate antitumor effect.

An antitumor aqueous solution manufacturing device of the invention that addresses the above-described problem is defined in claim <NUM>.

Although an active component for an antitumor effect provided by an antitumor aqueous solution has not been adequately revealed, research findings tell that the degree of antitumor effect correlates with the hydrogen peroxide concentration. By controlling the hydrogen peroxide concentration instead of controlling the antitumor effect based on the findings, an antitumor aqueous solution that provides an appropriate effect depending on the type of tumor can be manufactured. For the appropriate hydrogen peroxide concentrations, desirable hydrogen peroxide concentrations can be preparatorily obtained depending on the type of tumor.

PTL <NUM> discloses a water quality control device that decomposes organic substances in water to be processed by using hydrogen peroxide. The device disclosed in PTL <NUM> has a technology that controls electric power to be supplied to plasma electrodes, which are used for plasma irradiation, based on the hydrogen peroxide concentration in the water to be processed after plasma irradiation and that controls the distance between the plasma electrodes such that the irradiation can be continued under certain conditions even when a plasma generating device changes with time (for example, a change in the distance between the plasma electrodes due to wear of the plasma electrodes). That is, in PTL <NUM>, the technology controls the output and the distance between the plasma electrodes in accordance with a change with time of the plasma electrodes to make the effect through plasma irradiation constant; however, the invention of this application is a technology different from the technology of PTL <NUM> in that conditions such as a plasma irradiation time is changed to make the effect of an antitumor aqueous solution to be generated constant.

With the invention, by controlling the hydrogen peroxide concentration that correlates with the active component concentration instead of directly controlling the active component concentration through plasma irradiation, the manufacturing device capable of manufacturing an antitumor aqueous solution having an appropriate active component concentration depending on the tumor to which the antitumor aqueous solution is applied can be provided.

An antitumor aqueous solution manufacturing device of the invention is described below in detail with reference to the drawings for example. An antitumor aqueous solution manufacturing device of this embodiment manufactures an antitumor aqueous solution by irradiating a raw material solution with plasma and thereby generating an antitumor component in the raw material solution. The antitumor aqueous solution manufacturing device of this embodiment is implemented by atmospheric-pressure plasma irradiation device <NUM> described below that performs plasma irradiation under the atmospheric pressure.

Plasma irradiation is performed while the hydrogen peroxide concentration in the raw material solution is measured, and plasma irradiation is ended when the measured concentration has fallen in a predetermined concentration range. Because the hydrogen peroxide concentration correlates with the plasma irradiation conditions, controlling the hydrogen peroxide concentration provides an antitumor aqueous solution appropriately irradiated with plasma. The predetermined concentration range has appropriate values that vary in accordance with, for example, the type of tumor to which the antitumor aqueous solution is applied. The raw material solution during plasma irradiation may be left in a stationary state or in a circulation state. When plasma irradiation is performed, the raw material solution may be irradiated with plasma from above the solution surface.

The manufactured antitumor aqueous solution can affect a tumor existing in a living body by being directly administered to the living body. The administration of the antitumor aqueous solution to the living body can employ a method of bringing the antitumor aqueous solution into contact with the tumor in a state exposed by a surgical treatment. For example, when a tumor was attempted to be removed but was not completely removed by a surgical treatment, the remaining tumor can be killed by the contact between the antitumor aqueous solution and the tumor through washing or the like during the surgical treatment.

The raw material solution is an aqueous solution. For example, the raw material solution is desirably an aqueous solution prepared by adding a solute containing at least one component selected from disodium hydrogen phosphate (Na<NUM>HPO<NUM>), sodium hydrogen carbonate (NaHCO<NUM>), L-glutamine, L-histidine, and L-tyrosine disodium (L-tyrosine·2Na) to water. The raw material solution using the aqueous solution is irradiated with plasma and thus a highly effective antitumor aqueous solution with can be obtained. The raw material solution is desirably a living body fluid, or a culture solution for living body cells.

<FIG> illustrates atmospheric-pressure plasma irradiation device <NUM> of an embodiment of the invention. Atmospheric-pressure plasma irradiation device <NUM> irradiates a culture solution serving as a raw material solution with plasma under the atmospheric pressure. The culture solution is held in petri dish <NUM> in a stationary state.

Atmospheric-pressure plasma irradiation device <NUM> includes plasma generating device <NUM>, cover housing <NUM>, opening and closing mechanism <NUM>, stage <NUM> serving as a holding portion that holds the raw material solution in petri dish <NUM>, lifting and lowering device <NUM>, cooling device (see <FIG>) <NUM>, purge gas supply mechanism (see <FIG>) <NUM>, oxygen concentration detection mechanism <NUM>, hydrogen peroxide concentration detection mechanism (see <FIG>) <NUM>, exhaust mechanism <NUM>, and control device (see <FIG>) <NUM>. Note that a width direction of atmospheric-pressure plasma irradiation device <NUM> is referred to as X direction, a depth direction of atmospheric-pressure plasma irradiation device <NUM> is referred to as Y direction, and a direction perpendicular to the X and Y directions, that is, an up-down direction, is referred to as Z direction.

As illustrated in <FIG>, plasma generating device <NUM> includes cover <NUM>, upper block <NUM>, lower block <NUM>, one pair of electrodes <NUM>, and nozzle block <NUM>. Cover <NUM> substantially has a lidded rectangular tubular shape, and upper block <NUM> is arranged in cover <NUM>. Upper block <NUM> is substantially rectangular-parallelepiped and is formed of a ceramic. One pair of columnar recessed portions <NUM> are formed in a lower surface of upper block <NUM>.

Lower block <NUM> is substantially rectangular-parallelepiped and is formed of a ceramic. Recessed portion <NUM> is formed in an upper surface of lower block <NUM>, and recessed portion <NUM> is configured of one pair of columnar recessed portions <NUM> and connecting recessed portion <NUM> that connects one pair of columnar recessed portions <NUM> to each other. Lower block <NUM> is fixed to the lower surface of upper block <NUM> in a state in which lower block <NUM> protrudes from a lower end of cover <NUM>, and columnar recessed portions <NUM> of upper block <NUM> communicate with columnar recessed portions <NUM> of lower block <NUM>. Columnar recessed portions <NUM> and columnar recessed portions <NUM> have substantially the same diameter. A bottom surface of recessed portion <NUM> has slit <NUM> that extends through lower block <NUM> to a lower surface thereof.

One pair of electrodes <NUM> are arranged in columnar spaces defined by columnar recessed portions <NUM> of upper block <NUM> and columnar recessed portions <NUM> of lower block <NUM>. Electrodes <NUM> have an outer diameter smaller than the inner diameter of columnar recessed portions <NUM>, <NUM>. Nozzle block <NUM> has a substantially flat-plate shape and is fixed to the lower surface of lower block <NUM>. Nozzle block <NUM> has emission port <NUM> that communicates with slit <NUM> of lower block <NUM>, and emission port <NUM> extends through nozzle block <NUM> in the up-down direction.

Plasma generating device <NUM> further has processing gas supply device (see <FIG>) <NUM>. Processing gas supply device <NUM> supplies a processing gas in which an active gas, such as oxygen or hydrogen, is mixed with an inert gas, such as argon or nitrogen, at a given ratio; and processing gas supply device <NUM> is connected to the columnar spaces defined by columnar recessed portions <NUM>, <NUM> and an upper area of connecting recessed portion <NUM> via a pipe (not illustrated). Thus, the processing gas is supplied into recessed portion <NUM> from the gaps between electrodes <NUM> and columnar recessed portions <NUM> and from the upper area of connecting recessed portion <NUM>.

With the structure, plasma generating device <NUM> emits plasma from emission port <NUM> of nozzle block <NUM>. In detail, the processing gas is supplied into recessed portion <NUM> by processing gas supply device <NUM>. In this case, a voltage is applied to one pair of electrodes <NUM> and current flows between one pair of electrodes <NUM> in recessed portion <NUM>. Thus, an electrical discharge occurs between one pair of electrodes <NUM>, and the processing gas is plasmarized by the electrical discharge. The plasma is emitted from emission port <NUM> via slit <NUM>.

As illustrated in <FIG>, cover housing <NUM> includes upper cover <NUM> and lower cover <NUM>. Upper cover <NUM> substantially has a lidded cylindrical shape, and a lid of upper cover <NUM> has a through-hole (not illustrated) with a shape corresponding to lower block <NUM> of plasma generating device <NUM>. Cover <NUM> of plasma generating device <NUM> is fixed in a standing state on the lid of upper cover <NUM> so as to cover the through-hole. Thus, lower block <NUM> and nozzle block <NUM> of plasma generating device <NUM> protrude toward the inside of upper cover <NUM> so as to extend in the Z direction. Accordingly, plasma generated by plasma generating device <NUM> is emitted in the Z direction from emission port <NUM> of nozzle block <NUM> toward the inside of upper cover <NUM>.

Moreover, a side surface of upper cover <NUM> has three substantially rectangular through-holes (not illustrated) formed at three equally spaced positions, and transparent glass plates <NUM> are arranged so as to close the through-holes. Accordingly, the inside of upper cover <NUM> can be visually checked via glass plates <NUM>.

Lower cover <NUM> of cover housing <NUM> is substantially disk-shaped and is fixed to a casing (not illustrated) of a placing portion on which atmospheric-pressure plasma irradiation device <NUM> is placed. Lower cover <NUM> has a larger outer diameter than the outer diameter of upper cover <NUM>, and annular gasket <NUM> with the same diameter as the diameter of upper cover <NUM> is arranged on an upper surface of lower cover <NUM>. When upper cover <NUM> slides downward by opening and closing mechanism <NUM>, upper cover <NUM> comes into close contact with gasket <NUM>, and the inside of cover housing <NUM> is hermetically sealed.

In detail, as illustrated in <FIG> and <FIG>, opening and closing mechanism <NUM> includes one pair of slide mechanisms <NUM> and air cylinder <NUM>. Each of slide mechanisms <NUM> includes support shaft <NUM> and slider <NUM>. Support shaft <NUM> stands on the casing of the placing portion so as to extend in the Z direction. Moreover, slider <NUM> is substantially cylindrical, and is fitted onto support shaft <NUM> so as to be slidable in the axial direction of support shaft <NUM>.

Upper cover <NUM> is held at slider <NUM> by using upper bracket <NUM> and lower bracket <NUM>. Thus, upper cover <NUM> is slidable in the Z direction, that is, the up-down direction.

Air cylinder <NUM> includes rod <NUM>, a piston (not illustrated), and cylinder <NUM>. Rod <NUM> is arranged to extend in the Z direction, and an upper end portion of rod <NUM> is fixed to upper cover <NUM>. Moreover, a lower end portion of rod <NUM> is fixed to the piston. The piston is fitted into cylinder <NUM> from an upper end of cylinder <NUM>, and slidably moves in cylinder <NUM>. Cylinder <NUM> is fixed to the casing of the placing portion at the lower end portion, and a predetermined amount of air is sealed in cylinder <NUM>.

Thus, air cylinder <NUM> functions as a damper, and upper cover <NUM> is prevented from being rapidly lowered. The air pressure in cylinder <NUM> is a pressure that can be compressed by the weight of an integrated body that slides together with upper cover <NUM>, or more specifically, the weights of upper cover <NUM>, plasma generating device <NUM>, slider <NUM>, and another member. That is, when an operator releases upper cover <NUM> while upper cover <NUM> is lifted, upper cover <NUM> is lowered by the weight of upper cover <NUM> and another member. Upper cover <NUM> comes into close contact with gasket <NUM> of lower cover <NUM>, and as illustrated in <FIG>, the inside of cover housing <NUM> is hermetically sealed by upper cover <NUM> and lower cover <NUM>.

When the operator lifts upper cover <NUM>, the inside of cover housing <NUM> is opened. Magnets (see <FIG>) <NUM> are fixed to an upper surface of upper cover <NUM>, and when upper cover <NUM> is lifted, magnets <NUM> stick to the casing of the placing portion. When magnets <NUM> stick to the casing of the placing portion, the lifted state of upper cover <NUM>, that is, the open state of cover housing <NUM> is maintained.

Stage <NUM> is substantially disk-shaped, and petri dish <NUM> is placed on an upper surface of stage <NUM>. One or two hydrogen peroxide detection sensors (see <FIG>, not illustrated in the other drawings) <NUM> that are connected to hydrogen peroxide concentration detection mechanism <NUM> are arranged such that hydrogen peroxide detection sensors <NUM> can be inserted into petri dish <NUM>. Stage <NUM> has a smaller outer diameter than the outer diameter of lower cover <NUM>. Stage <NUM> is arranged on the upper surface of lower cover <NUM>.

As illustrated in <FIG>, lifting and lowering device <NUM> includes support rod <NUM>, rack <NUM>, pinion <NUM>, and electromagnetic motor (see <FIG>) <NUM>. Lower cover <NUM> has a through-hole (not illustrated) that extends therethough in the up-down direction, and support rod <NUM> is inserted through the through-hole. Support rod <NUM> has a smaller outer diameter than the inner diameter of the through-hole, and support rod <NUM> is movable in the up-down direction, that is, in the Z direction. The lower surface of stage <NUM> is fixed to an upper end of support rod <NUM>.

Rack <NUM> is fixed to an outer peripheral surface of a portion of support rod <NUM> extending downward from lower cover <NUM> to extend in the axial direction of support rod <NUM>. Pinion <NUM> meshes with rack <NUM>, and is rotated by driving of electromagnetic motor <NUM>. Pinion <NUM> is rotatably held by the casing of the placing portion. With the structure, when pinion <NUM> is rotated by driving of electromagnetic motor <NUM>, support rod <NUM> moves in the Z direction, and stage <NUM> is lifted and lowered. Gaging rod <NUM> stands on the upper surface of lower cover <NUM>, at a position next to stage <NUM>. An outer peripheral surface of gaging rod <NUM> has a scale, and the height of stage <NUM> in the Z direction, that is, the lifted and lowered amount of stage <NUM> can be visually checked by using the scale.

As illustrated in <FIG>, cooling device <NUM> includes cooling water channel <NUM>, circulation device <NUM>, and pipe <NUM>. Cooling water channel <NUM> extends through the inside of stage <NUM> in the plane direction of stage <NUM> to have an "angular C" shape, and is open at two positions of the outer peripheral surface of stage <NUM>. Circulation device <NUM> cools water and circulates the cooled water. Circulation device <NUM> is connected to cooling water channel <NUM> via pipe <NUM>. Thus, when cooling water flows in stage <NUM>, stage <NUM> is cooled.

As illustrated in <FIG>, purge gas supply mechanism <NUM> includes four air joints (in the drawing, three air joints are illustrated) <NUM> and purge gas supply mechanism (see <FIG>) <NUM>. Four air joints <NUM> are provided at four equally spaced positions at an upper end portion of a side surface of upper cover <NUM>, and air joints <NUM> are open to the inside of upper cover <NUM>. Purge gas supply device <NUM> supplies an inert gas such as nitrogen, and is connected to air joints <NUM> via pipes (not illustrated). With the structure, purge gas supply mechanism <NUM> supplies the inert gas such as argon into upper cover <NUM>.

Oxygen concentration detection mechanism <NUM> includes air joint <NUM>, pipe <NUM>, and oxygen detection sensor (see <FIG>) <NUM>. Lower cover <NUM> has a through-hole (not illustrated) that extends from the upper surface to the side surface of lower cover <NUM>. Opening <NUM> of the through-hole at the upper surface of lower cover <NUM> is positioned inside gasket <NUM>. In contrast, air joint <NUM> is connected to an opening of the through-hole at the side surface of lower cover <NUM>. Oxygen detection sensor <NUM> detects the oxygen concentration, and is connected to air joint <NUM> via pipe <NUM>. With the structure, oxygen concentration detection mechanism <NUM> detects the oxygen concentration in cover housing <NUM> when cover housing <NUM> is hermetically sealed.

As illustrated in <FIG>, exhaust mechanism <NUM> includes L-shaped pipe <NUM>, connecting pipe <NUM>, and main pipe <NUM>. As illustrated in <FIG>, lower cover <NUM> has duct port <NUM> that is open to the upper surface and a lower surface of lower cover <NUM>. The opening of duct port <NUM> at the upper surface of lower cover <NUM> defines tapered surface <NUM> having an inner diameter that increases upward. That is, when cover housing <NUM> is hermetically sealed, tapered surface <NUM> is inclined toward an inner wall surface of upper cover <NUM>. In contrast, L-shaped pipe <NUM> is connected to the opening of duct port <NUM> at the lower surface of lower cover <NUM>. Main pipe <NUM> is connected to L-shaped pipe <NUM> via connecting pipe <NUM>. Note that a portion of connecting pipe <NUM> near L-shaped pipe <NUM> is not illustrated. Moreover, ozone filter <NUM> is arranged in main pipe <NUM>. Ozone filter <NUM> is formed of activated carbon and sucks ozone.

As illustrated in <FIG>, control device <NUM> includes controller <NUM>, multiple drive circuits <NUM>, and selection device <NUM>. Multiple drive circuits <NUM> are connected to electrodes <NUM>, processing gas supply device <NUM>, electromagnetic motor <NUM>, circulation device <NUM>, and purge gas supply device <NUM>. Controller <NUM> includes a CPU, ROM, RAM, and the like, is mainly composed of a computer, and is connected to multiple drive circuits <NUM>. Thus, controller <NUM> controls operations of plasma generating device <NUM>, lifting and lowering device <NUM>, cooling device <NUM>, and purge gas supply mechanism <NUM>. Moreover, controller <NUM> is connected to oxygen detection sensor <NUM>, and hydrogen peroxide detection sensor <NUM> of hydrogen peroxide concentration detection mechanism <NUM>. Thus, controller <NUM> acquires detection results of oxygen detection sensor <NUM> and hydrogen peroxide detection sensor <NUM>, that is, the oxygen concentration in cover housing <NUM> and the hydrogen peroxide concentration in the raw material solution.

The RAM and ROM of controller <NUM> function as storage device <NUM>, and store values of appropriate hydrogen peroxide concentrations that are set for each of multiple purposes of use of antitumor aqueous solutions to be manufactured. The appropriate hydrogen peroxide concentrations can be previously set by an experiment or the like.

The antitumor aqueous solution that is manufactured by plasma irradiation device <NUM> of this embodiment has appropriate plasma irradiation conditions depending on the type of tumor to which the antitumor aqueous solution is applied, and the plasma irradiation conditions are handled as values of hydrogen peroxide concentrations. Selection device <NUM> that is connected to control device <NUM> selects the tumor to which the antitumor aqueous solution to be manufactured is applied.

In controller <NUM>, setting device <NUM> installed as a logic extracts values of corresponding hydrogen peroxide concentrations stored in the storage device in accordance with the type of tumor selected by selection device <NUM>, and sets the values as a predetermined range of the values of hydrogen peroxide concentrations that are used for control in a final phase of plasma irradiation. Although not particularly limited, an example of selection device <NUM> may be a keyboard, a mouse, a touch panel, or any type of switch that is generally used for a computer. Controller <NUM> performs plasma irradiation until the value of hydrogen peroxide concentration in the raw material solution falls within the predetermined range that has been set. As described above, a user can set appropriate hydrogen peroxide concentrations simply by selecting a type of tumor of an application target by using selection device <NUM> without inputting appropriate hydrogen peroxide concentrations, and can manufacture an antitumor aqueous solution that is manufactured through plasma irradiation under appropriate conditions.

By irradiating a raw material solution with plasma, the raw material solution is activated and an antitumor aqueous solution is obtained. Plasma irradiation is performed until the hydrogen peroxide concentration in the culture solution subjected to plasma irradiation falls within an appropriate range. For the appropriate range of hydrogen peroxide concentrations, desirable hydrogen peroxide concentrations can be preparatorily obtained depending on the type of tumor to which the antitumor aqueous solution is applied. The values of hydrogen peroxide concentrations are desirably values obtained through plasma irradiation that has been started from certain initial conditions. By setting the consistent initial conditions, the correlation between the antitumor component concentration and the hydrogen peroxide concentration in the antitumor aqueous solution is possibly enhanced.

With atmospheric-pressure plasma irradiation device <NUM>, using the configuration described above, by placing petri dish <NUM> storing the culture solution on stage <NUM> and hermetically sealing cover housing <NUM>, the culture solution can be irradiated with plasma under predetermined conditions. Hereinafter, a method of irradiating the culture solution with plasma under the predetermined conditions is described below in detail.

Specifically, petri dish <NUM> storing the culture solution is placed on stage <NUM>. Hydrogen peroxide detection sensor <NUM> is inserted into petri dish <NUM>. Then, stage <NUM> is lifted or lowered to a desirable height by using lifting and lowering device <NUM>. Thus, the distance between emission port <NUM> of plasma and the culture solution serving as a body to be irradiated with plasma can be desirably set. The lifted or lowered height of stage <NUM> can be checked by using the scale of gaging rod <NUM>.

Then, upper cover <NUM> is lowered and cover housing <NUM> is hermetically sealed. Purge gas supply mechanism <NUM> supplies the inert gas into cover housing <NUM>. At this time, oxygen concentration detection mechanism <NUM> detects the oxygen concentration in cover housing <NUM>. After the detected oxygen concentration has been below a previously set threshold, plasma generating device <NUM> emits plasma into cover housing <NUM>.

Before plasma irradiation is started, a target to which the antitumor aqueous to be manufactured is applied, and use conditions are selected by operating selection device <NUM>. Setting device <NUM> of controller <NUM> sets a predetermined range of values of hydrogen peroxide concentrations as a target with reference to data in the storage device based on the selected purpose of use. Plasma irradiation is performed until the hydrogen peroxide concentration in petri dish <NUM> falls within the predetermined range that has been set. Setting device <NUM> can set, in addition to the predetermined range of the values of hydrogen peroxide concentration, other plasma irradiation conditions (for example, irradiation output, oxygen concentration, and temperature of raw material solution) in accordance with the purpose of use selected by selection device <NUM>.

While plasma irradiation is performed, the inert gas is continuously supplied into cover housing <NUM>. Supplying the inert gas into cover housing <NUM> exhausts the air in cover housing <NUM> to the outside of cover housing <NUM>. In this case, the oxygen concentration in cover housing <NUM> is regulated, and the conditions that affect plasma irradiation are controlled. More specifically, since plasma contains active radicals, when the active radicals react with oxygen, the active radicals become ozone and decrease the effect of plasma irradiation. Regulating the oxygen concentration in cover housing <NUM> can control the influence of the oxygen concentration on the effect of the culture solution irradiated with plasma. In addition, the culture solution can be irradiated with plasma under the same conditions. Thus, the antitumor aqueous solution having a certain antitumor effect can be efficiently manufactured.

With atmospheric-pressure plasma irradiation device <NUM>, as described above, the distance between emission port <NUM> of plasma and the culture solution is desirably set. Thus, the irradiation distance, which is as a plasma irradiation condition, can be optimized, and the antitumor aqueous solution having a certain antitumor effect can be efficiently manufactured.

The plasma generating device radiates plasma from above the solution surface of the culture solution in petri dish <NUM>. Thus, plasma is radiated in a wide range and hence the processing speed is increased.

During plasma irradiation, cooling device <NUM> circulates cooling water in stage <NUM>. Cooling stage <NUM> restricts a temperature rise of the culture solution in petri dish <NUM> by plasma irradiation, and prevents the culture solution from vaporizing. Controlling the temperature of the cooling water regulates the temperature of the culture solution during plasma irradiation.

Lower cover <NUM> has duct port <NUM>. By this, when the inert gas is supplied into cover housing <NUM>, the pressure in cover housing <NUM> becomes positive pressure, and the gas is naturally exhausted from the inside of cover housing <NUM>. Moreover, duct port <NUM> of lower cover <NUM> has tapered surface <NUM> whose inner diameter increases toward the upper surface of lower cover <NUM>. Thus, the exhaust of the gas from the inside of cover housing <NUM> can be promoted. Further, exhaust mechanism <NUM> is provided with ozone filter <NUM>. Thus, even when plasma reacts with oxygen and ozone is generated, the exhaust of the ozone to the outside can be prevented.

Claim 1:
An antitumor aqueous solution manufacturing device (<NUM>) configured to manufacture an antitumor aqueous solution having an antitumor effect, comprising:
a holding portion (<NUM>), in the form of a stage (<NUM>), configured to hold a raw material solution in which a raw material of the antitumor aqueous solution is dissolved, wherein the holding portion (<NUM>) is configured to hold the raw material solution in a stationary state or in a repetitive circulation state;
a plasma generating device (<NUM>) configured to generate plasma to be radiated on the raw material solution in the holding portion (<NUM>), wherein the plasma generating device (<NUM>) is configured to radiate plasma from above a solution surface of the raw material solution held in the holding portion (<NUM>);
a hydrogen peroxide detection sensor (<NUM>) configured to measure a hydrogen peroxide concentration in the raw material solution in the holding portion (<NUM>); and
a control device (<NUM>) configured to control the plasma generating device (<NUM>),
wherein the control device (<NUM>) is configured to control the plasma generating device (<NUM>) such that the hydrogen peroxide concentration measured by the hydrogen peroxide detection sensor (<NUM>) falls within a predetermined range.