Patent Description:
The field of view refers to a range of space that can be seen when the head and the eyeballs are immobile and the eyes view an object in front, the size and shape of the field of view are related to the distribution of sensory cells on the retina, and the field of view can be measured by a perimeter. As one of the main clinical methods for visual function detection in ophthalmology, perimetry plays an important role in the diagnosis and follow-up of eye diseases such as glaucoma and optic nerve diseases. The perimetry includes kinetic perimetry and static perimetry. Kinetic perimetry: i.e., a conventional perimetry, in which test marks of different sizes are moved from different peripheral directions to the center, points where a patient can just feel the appearance or disappearance of the test marks are recorded, these points with the same light sensitivity constitute an isopter of test mark detection, and a similar "visual island" is drawn with several kinds of isopters measured by different test marks. The kinetic perimetry has the advantages of high speed and application to peripheral field of view, but has the disadvantage of low discovery rate of small and paracentral relative scotoma. Static perimetry: at each set point of a screen, the brightness of test marks is increased from weak to strong, and the brightness that a patient can just feel is a retinal sensitivity or threshold at that point. At present, the perimetry used in clinical practice is psychophysical examination, which reflects the subjective feeling of a patient.

Current computer automated perimeters used in clinical practice are mainly for the diagnosis and follow-up of glaucoma and partial retinal optic nerve diseases. However, for some early or clinically asymptomatic ocular diseases, the earliest defect changes of the field of view still cannot be found by the conventional computer perimetry. Therefore, ophthalmic researchers have been trying to develop a novel perimeter to achieve earlier, more stable, more sensitive and more specific detection of pathological changes. A variety of new perimetry methods currently developed, including short wavelength perimetry, kinesthetic perimetry, frequency-doubled perimetry, high-pass resolution and model discrimination perimetry, automatic pupil perimetry, flicker perimetry, micro-perimetry, etc., are specially designed to reflect visual impairment characteristics of different eye diseases. These novel perimeters have improved the performance of the conventional perimeters to a certain extent through different principles, but still have the following problems:.

In order to reduce the adverse influences, the current computer automated perimeter is designed with a "capture experiment" program to detect the false positive rate, false negative rate and fixation loss rate in each test. In order to avoid the influence of mechanical sound and patient habits, the computer automated perimeter produces a mechanical sound proportionally without light stimulation, and if the patient responds, the test result is false positive. An extremely bright light stimulus is present in the area where the threshold has been established. If the patient is unable to respond, it indicates that the patient is distracted and the test result is false negative. When photo-electricity is randomly projected into a physiological blind area, if the number of times the patient responds exceeds a certain limit, there is no central fixation. This method can reduce the influences of the fixation point and the patient's subjective operation, but still cannot solve the problem fundamentally, resulting in the deficiencies of repeatability, specificity, sensitivity and accuracy.

The eyeball is a bipolar ball. The cornea presents a positive potential relative to the retina, and there is a potential difference between the cornea and retina, thus forming an electric field around the eye. When the eyeball rotates, the spatial phase of the electric field is changed. Eye movement can produce bio-electricity, so a potential difference exists between the cornea and the retina, and the cornea is positively charged with respect to the retina. When the eye is gazing at the front without moving, a stable reference potential can be recorded. When the eye moves in the horizontal direction, the potential difference between the left and right skin of the eye is changed. When the eye moves in the vertical direction, the upper and lower potentials of the eye are changed. The change in potentials is guided into an amplifier by an electrode placed at a corresponding position of the skin, and an electro-oculogram signal is displayed by a galvanometer with the amplifier or displayed on an oscilloscope. A visual electro-physiological instrument can objectively provide a diagnosis basis for diseases at each layer of the retina and each segment of the visual pathway by analyzing the bio-electrical changes of the visual system for light stimulation, reflecting the functional statuses of the retina and the visual pathway, and adjusting the stimulation condition and acceptance way. At present, the electro-physiological examination technology is applied to the early detection of glaucoma in clinical practice. Judging the impairment or progression of the glaucoma is mainly through the waveform of an electro-physiological signal. Although the objective examination device can objectively reflect the patient's retinal impairment, the patient is required to always gaze at the screen during the whole examination, and the change in patient's eye position may cause the waveform to change, so that multiple examination results of the same patient may be greatly different. In addition, the waveform varies among different individuals of crowds, and it is difficult to determine the normal value, abnormal range and other issues, so the electro-physiological examination technology is hardly really applied to the detection of glaucoma.

<CIT> discloses a cup shaped fiberoptic fundoscope coupler device. Coupler device includes a suction device that is used to detachably adhere coupler device to eye. D1 further discloses an examination tool (specifically a fundoscope), which is coupled to the to the coupler device by a fiberoptic cable. <CIT> discloses a perimeter for subjective detection of a test stimulus on a specific background, and can be used for early diagnosis of primary glaucoma and other diseases that limit the field of vision of the human eye. It does not discloses however any eyeball fixation device.

In order to solve the above technical problems, the present invention is directed to provide a perimeter capable of eliminating the influence of a fixation point on perimetry. The specific technical solution is as follows. Aspects of the present invention are defined in the claims.

A perimeter is divided into two types according to different feedback devices: one is a fixation forcing perimeter, and the other is an objective perimeter combined with electro-physiology under forced fixation. The perimeter includes a fixation forcing device, a display conduction device, a perimetry display device, a feedback device for recording feedback information, and a control center for controlling the perimetry display device and collecting feedback information, wherein the fixation forcing device is suitable for adsorbing to an eyeball and forcing the eyeball in a fixation state during perimetry, and the display conduction device comprises light guide fibers connected to the fixation forcing device and the perimetry display device respectively. The fixation forcing device is adsorbed to the eyeball of a testee by negative pressure, the eye can observe the perimetry display device through the display conduction device, the control center controls images displayed on the perimetry display device through a predetermined control program, the testee makes corresponding feedbacks according to the changing images on the perimetry display device, the feedback information is recorded in the feedback device, and the testee's field of view is measured accordingly. The relative positions of the fixation forcing device and the eyeball are fixed, the relative positions of the perimetry display device and the fixation forcing device are fixed, and when the eyeball moves, the relative positions of the gazed perimetry display device and the eyeball do not change, thereby eliminating the influence of the fixation point of the conventional perimeter on the results, and improving the accuracy and repeatability of the perimetry.

In the above technical solution, the fixation forcing device includes a negative pressure ring, a hole is formed in the middle of the negative pressure ring, and the display conduction device is fixedly arranged at the hole. The negative pressure ring is connected to a negative pressure device through a negative pressure tube to form certain negative pressure between the eyeball and the negative pressure ring, thereby fixing the negative pressure ring to the eyeball. When the test is over, the negative pressure device is closed to remove the negative pressure ring from the eyeball. In the above technical solution, the fixation forcing device includes a negative pressure ring and a negative pressure tube connected to the negative pressure ring, an observation cylinder is connected to the middle of the negative pressure ring, one end of the observation cylinder is connected to the middle of the negative pressure ring, the display conduction device is fixedly arranged at the other end of the observation cylinder, and the display conduction device can conduct images on the perimetry display device. The observation cylinder is provided with an observation hole in the center, and a lens set is arranged in the observation hole. The negative pressure ring is forcibly fixed on the eyeball, the testee gazes at the perimetry display device through the observation cylinder and the display conduction device, the negative pressure ring adsorbed to the eyeball can move synchronously with the rotation of the eyeball without adjusting the illumination angle, the images are always in front of the eye, and the patient only needs to respond to the light stimulus without distracting to perform fixation on a certain point. Since the relative positions of the eyeball and the perimetry display device are fixed, after the influence of the fixation point on the patient's examination result is eliminated, the perimetry is greatly improved in terms of repeatability, specificity, sensitivity and accuracy.

In the above technical solution, the display conduction device includes two types, one type includes a projection screen and light guide fibers connected to the projection screen, the projection screen is connected to the fixation forcing device, one ends of the light guide fibers are connected to the projection screen, and the other ends are connected to the perimetry display device to project an image on the perimetry display device into the eye; the other type includes only light guide fibers, the light guide fibers are arranged in a certain way and connected to the fixation forcing device, and the other ends are connected to point light sources to directly project light points of the point light sources into the eye.

In the above technical solution, for the fixation forcing perimeter, the feedback device is a signal collector, and when the testee observes the image on the perimetry display device, the testee triggers the signal collector to record the feedback information of the testee.

In the above technical solution, for the objective perimeter, the feedback device is an electro-physiological examination instrument for recording an electro-physiological signal generated when the testee observes an image on the perimetry display device, thereby examining the testee's field of view. After the negative pressure ring is fixed to the eyeball, the testee is forced to perform fixation on the perimetry display device, which can enhance the time, frequency and range of light stimulation and realize repeated stimulation of single-point light similar to the perimetry. The patient's field of view is judged by analyzing the frequency and time of stimulation of the single-point light and whether the patient produces electro-physiological signals, and any operation of the patient is not required in such a mode, thereby eliminating the influence of the fixation point and the testee's subjective operation, obtaining a real objective perimeter, and greatly improving the accuracy and repeatability of physical examination.

In the above technical solution, the control center is a computer loaded with an artificial intelligence algorithm, and can automatically perform personalized display adjustment according to the age of the patient and the previous examination status and perform personalized processing on the collected feedback data. The personalized display adjustment includes highlighting a previous blind area of the field of view and/or a possible blind area.

In which: projection screen <NUM>, negative pressure ring <NUM>, negative pressure tube <NUM>, observation cylinder <NUM>, lens set <NUM>, light guide fiber <NUM>, button <NUM>, multifunctional chair <NUM>, support rod <NUM>.

The present invention will be further described in detail below in combination with the accompanying drawings.

Embodiment <NUM>, referring to <FIG> and <FIG>, the perimeter includes a projection screen <NUM>, a computer (control center) for controlling an image displayed on the projection screen <NUM>, and a feedback device for recording feedback information. The perimeter further includes a negative pressure ring <NUM>, a negative pressure tube <NUM> connected to the negative pressure ring <NUM>, and an observation cylinder <NUM> in the middle of the negative pressure ring. The observation cylinder <NUM> is provided with an observation hole in the center, one end of the observation cylinder <NUM> is connected to the middle of the negative pressure ring <NUM>, and the projection screen <NUM> is fixedly arranged at the other end of the observation cylinder. A lens set is disposed in the observation hole, the projection screen <NUM> is connected to a perimetry display device (not shown) through light guide fibers <NUM>, and the projection screen <NUM> projects and displays the content displayed by the perimetry display device. The negative pressure tube <NUM> is connected to a negative pressure pump (not shown). The negative pressure pump provides an adsorption force for the negative pressure ring, so that the negative pressure ring <NUM> can be reliably adsorbed to the eyeball. The main function of the lens set <NUM> is to correct the refractive status of a patient, so that the patient can clearly gaze at the image on the projection screen <NUM>. The content on the projection screen <NUM> can be changed by changing the content displayed by the perimetry display device through the computer to obtain different images. <FIG> shows an embodiment in which the perimeter of the present invention is arranged on a multifunctional chair. When a patient is tested for the field of view, the angle of a backrest of the multifunctional chair <NUM> can be adjusted, and a support rod <NUM> is adjusted to be directly above the patient's eye. The image type, intensity, stimulation frequency, stimulation time, etc. on the perimetry display device are controlled by the computer, the negative pressure ring <NUM> is adsorbed to the eyeball, and the patient gazes at the image projected by the light guide fibers <NUM>, and presses a button <NUM> when seeing the image, recorded as +. If the button <NUM> is not pressed, that is, the patient does not see the image, recorded as -. All feedback information is fed back to a signal collector for result calculation and recording, and the patient's field of view is finally exported. It should be noted that the signal collector may be the computer or a separate mechanism.

Embodiment <NUM>, referring to <FIG>, the negative pressure ring <NUM> is provided with a hole in the middle, and the projection screen <NUM> is directly fixed to the circular hole. The projection screen <NUM> is connected with light guide fibers <NUM>, and in this mode, the other ends of the light guide fibers are directly connected to point light sources. Each bundle of light guide fibers is an independent stimulation point, which is connected to an independent point light source. The dotted line in <FIG> shows the distribution of the light guide fibers. The position and intensity of stimulating light on the projection screen are adjusted by controlling each point light source. The negative pressure ring is adsorbed to the eyeball by self-adsorption, or adsorbed to the eyeball by means of a negative pressure pump. Due to the self-adsorption, the mechanisms such as a negative pressure tube and a negative pressure pump are removed, which is beneficial to simplifying the adsorption device. Optionally, a transparent layer may be provided at the hole to isolate the eyeball from the screen so as to avoid direct contact of the eyeball with the screen. It should be noted that the projection screen <NUM> may be removed, the light guide fibers are arranged in a certain way and connected to the fixation forcing device, and the other ends are connected to point light sources to directly project light points of the point light sources into the eye, where such an arrangement may be scattering from the center to four sides as shown in <FIG>.

In the above technical solution, for the objective perimeter, the feedback device is replaced with an electro-physiological examination instrument (not shown) for recording an electro-physiological signal generated when a testee observes an image on the perimetry display device, so that the testee's field of view is examined, the patient does not need to respond to the stimulation, and objective examination is achieved.

It should be noted that the perimeter of the present invention may be used alone, and is not necessarily arranged on the multifunctional chair; the projection screen may also be a curved screen more fitting to the eyeball, such as an OLED screen; the observation area on the fixation forcing device may be set in any shape; the fixation forcing device is not necessarily limited to a ring, as long as the fixation forcing device can be adsorbed to the eyeball and the display conduction device is fixed to the fixation forcing device.

Claim 1:
A perimeter, comprising a fixation forcing device, a display conduction device, a perimetry display device, a feedback device for recording feedback information, and a control center for controlling the perimetry display device and collecting feedback information, wherein the fixation forcing device is suitable for adsorbing to an eyeball and forcing the eyeball in a fixation state during perimetry, and the display conduction device comprises light guide fibers connected to the fixation forcing device and the perimetry display device respectively.