Patent Description:
According to statistics from the World Health Organization, cardioblood vessel diseases have become the "top killer" of human health. In recent years, analysis of the physiology and pathological behaviors of the cardioblood vessel diseases using hemodynamics has also become a very important method for the diagnosis of the cardioblood vessel diseases.

Fractional flow reserve (FFR) may indicate an influence of coronary artery stenosis lesion on distal blood flow and diagnosis of myocardial ischemia, and thus has become a recognized indicator of the functional evaluation of the coronary artery stenosis. FFR is defined as a ratio of the maximum blood flow to the myocardium in the innervated region provided by the coronary artery stenosis to the maximum blood flow to the myocardium provided by the same normal coronary artery. The FFR may be simplified as a ratio of a mean intracoronary pressure (Pd) at a distal end of the stenosis in a myocardium's maximum hyperemia state to a mean aortic pressure (Pa) at a coronary artery inlet, that is, FFR = Pd/Pa.

When determining FFR, it is necessary to calculate FFR based on a blood flow velocity and the mean aortic pressure (Pa) at the coronary artery inlet in the myocardium's maximum hyperemia state, and the mean intracoronary pressure at the distal end of the stenosis obtained by different technical means. However, intracoronary injection or intravenous injection of adenosine or ATP is required for maximum hyperemia of the myocardium, and the injection of adenosine or ATP will decrease the aortic pressure and will cause a certain side effects, such as atrioventricular block, sinus bradycardia, and sinus arrest, and contraindications include second degree atrioventricular block, third degree atrioventricular block, sinoatrial node diseases, tracheal or bronchial asthma, and adenosine allergy.

Instantaneous wave-free ratio (iFR) can provide a method for measuring intracoronary pressure similar to Fractional Flow Reserve (FFR). iFR does not require a vasodilator, is easy to operate, and will be more frequently used in coronary artery interventional therapy.

At present, the existing measurement methods for coronary artery blood vessel evaluation parameters are mainly: (<NUM>) measurement by pressure guide wire, which is expensive, difficult and risky; (<NUM>) measurement through two-dimensional coronary artery angiographic images by obtaining a real-time aortic pressure Pa and the measured full-cycle blood flow velocity v, resulting in obtaining only full-cycle coronary artery blood vessel evaluation parameters instead of blood vessel evaluation parameters in a diastolic phase in an angiographic state; and there is no screening of the aortic pressure Pa and the blood flow velocity v, resulting in inaccurate blood vessel evaluation parameters.

<CIT> discloses an apparatus and method for use with a set of angiographic images of a lumen of a subject's body. Temporal changes in a density of a contrast agent at a given location within the lumen are analyzed via image processing. In response to the analysis, a characteristic of the lumen at the location is determined, and, in response thereto, an output is generated.

<CIT> discloses a three-dimensional fluid simulation method wherein: a first mesh of a flow domain non-uniformly split with respect to each of three degrees of freedom is defined; a second mesh uniformly sprit with respect to only one of the three degrees of freedom but non-uniformly with respect to other two degrees is defined; an object model is set in the first mesh and a motion equation is formed and calculated to obtain fluid velocity; based on the fluid velocity, flow imbalance is computed for each cell; based on the flow imbalance, fluid pressure correction equation is formed; the flow imbalance is mapped onto the second mesh and the fluid pressure correction is computed; the fluid pressure correction is mapped onto the first mesh; and until the flow imbalance and motion equations are converged the computation is repeated.

The disclosure provides a method, device and system for acquiring blood vessel evaluation parameters based on an angiographic image in accordance with the appended claims. The method, device and system solve the problems of being unable to obtain blood vessel evaluation parameters during diastolic phase and inaccurate measured blood vessel evaluation parameters by obtaining Pa-t pressure wave and v-t velocity waveform in time domain.

The beneficial effects brought by the solutions provided by the embodiments of the disclosure at least comprise:.

the disclosure provides a method for acquiring coronary artery blood vessel evaluation parameters based on an angiographic image, by acquiring Pa-t pressure waveform in an angiographic state in the time domain, and then subjecting the coronary artery two-dimensional angiographic image in the angiographic state to three-dimensional modeling to obtain v-t velocity waveform in the time domain, thereby realizing the measurement of the coronary artery vessel evaluation parameters in a diastolic phase; further, filtering interference data through the Fourier transform improves the accuracy of the coronary artery vessel evaluation parameter measurement.

The drawings described here are configured to provide a further understanding of the disclosure and constitute a part of the disclosure. The exemplary embodiments and descriptions of the disclosure are configured to explain the disclosure, and do not constitute an improper limitation of the disclosure. In the attached drawings:.

The reference signs are described below:
blood pressure acquisition device <NUM>, main body <NUM>, first power drive device <NUM>, blood pressure acquisition unit <NUM>, first control device <NUM>, fixed block <NUM>, second control device <NUM>, infusion device <NUM>, infusion tube <NUM>, three-dimensional modeling unit <NUM>, blood flow velocity unit <NUM>, pressure drop unit <NUM>, coronary artery blood vessel evaluation parameter unit <NUM>, Fourier transform module <NUM>, pressure drop calculation module <NUM>, Fourier transform inverse module <NUM>, caiFR module <NUM>, cadPR module <NUM>, caDFR module <NUM>, and caFFR module <NUM>.

In order to make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be described clearly and completely in conjunction with specific embodiments of the present invention and the corresponding drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

Hereinafter, a number of embodiments of the present invention will be disclosed in drawings. For clear description, many practical details will be described in the following description. However, it should be understood that these practical details should not be configured to limit the present invention. In other words, in some embodiments of the present invention, these practical details are unnecessary. In addition, in order to simplify the drawings, some conventionally used structures and components will be shown in simple schematic ways in the drawings.

The existing methods for measuring the evaluation parameters of coronary artery blood vessel are mainly: (<NUM>) measurement by pressure guide wire, which is expensive, difficult and risky; (<NUM>) measurement through two-dimensional coronary artery angiographic images by obtaining a real-time aortic pressure Pa and the measured full-cycle blood flow velocity v, resulting in obtaining only full-cycle coronary artery blood vessel evaluation parameters instead of blood vessel evaluation parameters in a diastolic phase in an angiographic state; and there is no screening of the aortic pressure Pa and the blood flow velocity v, resulting in inaccurate blood vessel evaluation parameters.

In order to solve the above problems, a method, device, system and storage medium for acquiring the blood flow of the cardiac superficial aorta.

As shown in <FIG>, the present disclosure provides a method for acquiring coronary artery blood vessel evaluation parameters based on an angiographic image, comprising:.

The wave-free is defined as a certain period of time in the diastolic phase, which is called the wave-free period.

The calculation time for the instantaneous wave-free period is calculated from <NUM>% of the time after the start of the wave-free period to <NUM> before the start of a systolic phase.

(<NUM>) The fractional flow reserve caFFR is obtained through the fourth mean pressure of aorta Pa<NUM> and the fourth mean pressure of a distal end of coronary artery stenosis Pd<NUM> in the whole cardiac cycle, namely: <MAT>.

In another embodiment of the present disclosure, the blood flow velocity v in S300 is calculated by v = ΔL/fps , where ΔL represents the length difference between the blood vessels in which the contrast agents of two adjacent frames of image are flowing, and fps represents the number of frames transmitted per second.

As shown in <FIG>, the present disclosure provides an device for acquiring coronary artery blood vessel evaluation parameters based on an angiographic image and the device is used in the method for acquiring coronary artery blood vessel evaluation parameters based on the angiographic image, and the device comprises: a blood pressure acquisition device <NUM>, and a three-dimensional modeling unit <NUM>, a blood flow velocity unit <NUM>, a pressure drop unit <NUM>, and a coronary artery blood vessel evaluation parameter unit <NUM> connected in sequence, and the blood pressure acquisition device <NUM> is connected to the pressure drop unit <NUM>; the blood pressure acquisition device <NUM> is connected to an external catheter for angiography and for acquiring a real-time pressure Pa at a coronary artery inlet in an angiographic state to obtain a Pa-t pressure waveform in time domain; the three-dimensional modeling unit <NUM> is configured for reading the coronary artery angiographic image in the angiographic state, and subjecting a segment of blood vessel of interest in the image to three-dimensional modeling to obtain a three-dimensional grid model for the blood vessel; the blood flow velocity unit <NUM> is configured for receiving the three-dimensional grid model for the blood vessel sent by the three-dimensional modeling unit <NUM> and acquiring a real-time blood flow velocity v of the segment of blood vessel of interest to obtain v-t velocity waveform in the time domain; as shown in <FIG>, the pressure drop unit <NUM> also comprises: a Fourier transform module <NUM>, a pressure drop calculation module <NUM>, and a Fourier transform inverse module <NUM> sequentially connected, and a Fourier transform module <NUM> is configured to receive the v-t velocity waveform and the Pa-t pressure waveform in the time domain sent by the blood flow velocity unit <NUM> and the blood pressure acquisition device <NUM>, respectively, and the blood flow velocity v and pressure Pa is subjected to Fourier transform to obtain v'-t velocity waveform and Pa'-t pressure waveform in frequency domain; the pressure drop calculation module <NUM> is then configured to acquire a ΔP'-t pressure drop waveform in the frequency domain from the coronary artery inlet to the distal end of the coronary artery stenosis based on the v'-t velocity waveform and Pa'-t pressure waveform in the frequency domain sent by the Fourier transform module <NUM>; the Fourier transform inverse module <NUM> is configured to acquire the ΔP-t pressure drop waveform from the coronary artery inlet to the distal end of the coronary artery stenosis in the time domain through the inverse Fourier transform according to the ΔP'-t pressure drop waveform sent by the pressure drop calculation module <NUM>; the coronary artery blood vessel evaluation parameter unit <NUM> is configured for receiving the Pa-t pressure waveform and the ΔP-t pressure drop waveform in the time domain sent by the blood pressure acquisition device <NUM> and the pressure drop unit <NUM> to acquire the coronary artery blood vessel evaluation parameters.

In an embodiment of the present disclosure, as shown in <FIG>, the coronary artery blood vessel evaluation parameter unit <NUM> further comprises: a caiFR module <NUM>, a cadPR module <NUM>, a caDFR module <NUM>, and a caFFR module <NUM>, which are all connected to the Fourier transform inverse module <NUM>. The cadPR module <NUM> is configured to select the waveform in the full diastolic phase from the Pa-t pressure waveform and the ΔP-t pressure drop waveform in the time domain sent by the pressure drop unit <NUM>, and obtain the first diastolic phase pressure ratio cadPR through the first mean pressure of aorta Pa<NUM> in the full diastolic phase and the first mean pressure of a distal end of artery stenosis Pd<NUM>; the caDFR module <NUM> is configured to select an interval waveform from Pm < Pa<NUM> to the aortic pressure Pn=Pmin from the Pa-t pressure waveform and the ΔP-t pressure drop waveform in the time domain sent by the pressure drop unit <NUM>, and obtain the ratio of a diastolic phase less than the average pressure caDFR through the second mean pressure of aorta Pa<NUM> and the second mean pressure of a distal end of coronary artery stenosis Pd<NUM>, wherein Pm and Pn indicate mth and nth aortic pressures during the diastolic phase, respectively; the caiFR module <NUM> is configured to select the waveform in the wave-free period from the Pa-t pressure waveform and the ΔP-t pressure drop waveform in the time domain sent by the pressure drop unit <NUM>, and obtain the instantaneous wave-free ratio caiFR through the third mean pressure of aorta PQ<NUM> and the third mean pressure of a distal end of coronary artery stenosis Pd<NUM> within the period of wave-free; the fractional flow reserve caFFR is configured to select all data from the Pa-t pressure waveform and the ΔP-t pressure drop waveform in the time domain sent by the pressure drop unit <NUM> as the whole cardiac cycle data, and obtain fractional flow reserve caFFR through the fourth mean pressure of aorta Pa<NUM> and the fourth mean pressure of a distal end of coronary artery stenosis Pd<NUM> in the whole cardiac cycle.

In an embodiment of the present disclosure, as shown in <FIG>, the blood pressure acquisition device <NUM> comprises: a main body <NUM>, and a first power drive device <NUM>, a blood pressure acquisition unit <NUM>, and a first control device <NUM> that are all connected to the main body <NUM>; the main body <NUM> is configured to control whether the first power drive device <NUM>, the blood pressure acquisition unit <NUM>, and the first control device <NUM> start working; the blood pressure acquisition unit <NUM> is connected to the second control device <NUM>, and the second control device <NUM> is connected to an external interventional device; the second control device <NUM> is configured for zeroing the blood pressure acquisition unit <NUM> and for controlling whether the blood pressure acquisition unit <NUM> is in communication with the external interventional device; the first power drive device <NUM> is arranged on the main body <NUM>, and the first power drive device <NUM> is connected to the external infusion device <NUM>, and the first power drive device <NUM> is configured to drive the liquid flow of the external infusion device <NUM>; the blood pressure acquisition unit <NUM> is arranged on the main body <NUM>, and the blood pressure acquisition unit <NUM> is connected to the first control device <NUM> and the external interventional device, and the blood pressure acquisition unit <NUM> is configured to collect the invasive arterial pressure; the first control device <NUM> is fixed on the main body <NUM> through the fixing block <NUM>, etc.; the first control device <NUM> is connected to the external infusion device <NUM> for controlling the liquid flow direction of the infusion device <NUM>, which causes the liquid to flow from the infusion device <NUM> to the first control device <NUM>. The present disclosure provides a blood pressure acquisition device, and by setting the first power drive device <NUM>, the blood pressure acquisition unit <NUM>, and the first control device <NUM> on the main body <NUM> and by opening the first control device <NUM>, the blood pressure acquisition unit <NUM> is in communication with the external infusion device <NUM> and atmosphere at the same time, so that the first power drive device <NUM> drives the liquid flow inside the infusion tube <NUM> on the external infusion device <NUM>, thereby realizing automatic discharge without manual discharge, which is simple and convenient to operate; the automatic zero calibration of the blood pressure acquisition unit <NUM> can be realized by setting the second control device <NUM>; because the height change of the operating bed will affect the measurement of the invasive arterial pressure, the height of the blood pressure acquisition device needs to be changed during an operation, and there is no need to repeat the zero calibration many times, and the operation is simple and the measurement is accurate.

In a third aspect, the present disclosure provides a coronary artery analysis system, comprising: the above device for acquiring coronary artery blood vessel evaluation parameters based on an angiographic image.

In a fourth aspect, the present disclosure provides a computer storage medium, and when the computer program is executed by a processor, the above method for acquiring coronary artery blood vessel evaluation parameters based on an angiographic image is realized.

Those skilled in the art know that various aspects of the present invention can be implemented as a system, a method, or a computer program product. Therefore, each aspect of the present invention can be specifically implemented in the following forms, namely: complete hardware implementation, complete software implementation (comprising firmware, resident software, microcode, etc.), or a combination of hardware and software implementations, Here can be collectively referred to as "circuit", "module" or "system". In addition, in some embodiments, various aspects of the present invention may also be implemented in the form of a computer program product in one or more computer-readable media, and the computer-readable medium contains computer-readable program code. Implementation of methods and/or systems of embodiments of the present invention may involve performing or completing selected tasks manually, automatically, or a combination thereof.

For example, hardware for performing selected tasks according to an embodiment of the present invention may be implemented as a chip or a circuit. As software, selected tasks according to an embodiment of the present invention can be implemented as a plurality of software instructions executed by a computer using any suitable operating system. In an exemplary embodiment of the present invention, a data processor performs one or more tasks according to an exemplary embodiment of a method and/or system as herein, such as a computing platform for executing a plurality of instructions. Optionally, the data processor includes a volatile memory for storing instructions and/or data and/or a non-volatile memory for storing instructions and/or data, for example, a magnetic hard disk and/or a removable medium. Optionally, a network connection is also provided. Optionally, a display and/or user input device, such as a keyboard or mouse, is also provided.

Any combination of one or more computer readable can be utilized. The computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium. The computer-readable storage medium may be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the above. More specific examples (non-exhaustive list) of computer-readable storage media would include the following:.

Electrical connection with one or more wires, portable computer disk, hard disk, random access memory (RAM), read only memory (ROM), erasable programmable read only memory (EPROM or flash memory), optical fiber, portable compact disk read only memory (CD-ROM), optical storage device, magnetic storage device, or any suitable combination of the above. In this document, the computer-readable storage medium can be any tangible medium that contains or stores a program, and the program can be used by or in combination with an instruction execution system, apparatus, or device.

The computer-readable signal medium may include a data signal propagated in baseband or as a part of a carrier wave, and computer-readable program code is carried therein. This propagated data signal can take many forms, comprising but not limited to electromagnetic signals, optical signals, or any suitable combination of the above. The computer-readable signal medium may also be any computer-readable medium other than the computer-readable storage medium. The computer-readable medium may send, propagate, or transmit the program use by or in combination with the instruction execution system, apparatus, or device.

The program code contained on the computer-readable medium can be transmitted by any suitable medium, comprising (but not limited to) wireless, wired, optical cable, RF, etc., or any suitable combination of the foregoing.

For example, any combination of one or more programming languages can be configured to write computer program codes for performing operations for various aspects of the present invention, comprising object-oriented programming languages such as Java, Smalltalk, C++, and conventional process programming languages, such as "C" programming language or similar programming language. The program code may be executed entirely on the user's computer, partly on the user's computer, executed as an independent software package, partly on the user's computer and partly executed on a remote computer, or entirely executed on the remote computer or server. In the case of a remote computer, the remote computer can be connected to the user's computer through any kind of network comprising a local area network (LAN) or a wide area network (WAN), or it can be connected to an external computer (for example, using an Internet service provider to pass Internet connection).

It should be understood that each block of the flowchart and/or block diagram and the combination of each block in the flowchart and/or block diagram may be implemented by computer program instructions. These computer program instructions can be provided to the processors of general-purpose computers, special-purpose computers, or other programmable data processing devices, thereby producing a machine that makes these computer program instructions when executed by the processors of the computer or other programmable data processing devices, a device that implements the functions/actions specified in one or more blocks in the flowchart and/or block diagram is produced.

It is also possible to store these computer program instructions in a computer-readable medium. These instructions make computers, other programmable data processing devices, or other devices work in a specific manner, so that the instructions stored in the computer-readable medium generate an article of manufacture that implements instructions for functions/actions specified in one or more blocks in the flowchart and/or block diagram.

Computer program instructions can also be loaded onto a computer (for example, a coronary artery analysis system) or other programmable data processing equipment to cause a series of operation steps to be performed on the computer, other programmable data processing equipment or other equipment to produce a computer-implemented process , causing instructions executed on a computer, other programmable device or other equipment to provide a process for implementing the functions/actions specified in the flowchart and/or one or more block diagrams.

Claim 1:
A method for acquiring coronary artery blood vessel evaluation parameters based on an angiographic image, characterized in that, comprising the following steps:
acquiring (S100) a real-time pressure Pa at a coronary artery inlet in an angiographic state to obtain a Pa-t pressure waveform in time domain;
subjecting (S200) a segment of blood vessel of interest in a two-dimensional angiographic image of the coronary artery in an angiographic state to three-dimensional modeling to obtain a three-dimensional grid model for the blood vessel;
acquiring (S300) a real-time blood flow velocity v of the three-dimensional grid model for the blood vessel to obtain a v-t velocity waveform in the time domain;
subjecting (S400) the blood flow velocity v and pressure Pa to Fourier transform to obtain v'-t velocity waveform and Pa'-t pressure waveform in frequency domain;
acquiring (S500) a ΔP'-t pressure drop waveform in the frequency domain from the coronary artery inlet to a distal end of the coronary artery stenosis based on the v'-t velocity waveform and Pa'-t pressure waveform in the frequency domain;
acquiring (S600) the ΔP-t pressure drop waveform from the coronary artery inlet to the distal end of the coronary artery stenosis in the time domain through the inverse Fourier transform;
acquiring (S700) the coronary artery blood vessel evaluation parameters in the angiographic state based on the Pa-t pressure waveform and the ΔP-t pressure drop waveform in the time domain.