Patent Description:
Disposable wearable articles, in particular, disposable diapers, often pose skin problems, particularly, skin rash of wearers. Such problems may result from physical irritation (friction or coarseness) to the skin or decrease in a barrier function of cutis caused by skin dryness of wearers.

There is proposed to cause a wax-like substance having a higher softening point than the human body temperature to be contained in a nonwoven top sheet for reducing friction between the skin of a wearer and the top sheet (Patent Literature <NUM>).

For the purpose of reducing friction and the like, there is also known to apply a hydrophilic lotion to a nonwoven top sheet (Patent Literature <NUM>). This hydrophilic lotion is preferred for its capability of avoiding hardness of the wax-like substance or lowering of liquid-permeability. In particular, a water-containing hydrophilic lotion is preferred for keeping the skin from drying.

However, there is still room for improvement as for suppression of diaper rash. For example, since infants have sensitive skin, the so-called diaper rash is likely to be occurred on their skin.

It is therefore a primary object of the present invention to provide disposable wearable articles having a beneficial effect on the prevention of skin rash.

A disposable wearable article that has solved the above problem is as follows.

A disposable wearable article including a top sheet (<NUM>) having a skin-touching region (30E) that is brought into contact with skin of a wearer,.

The present disposable wearable article is characterized in that in the top sheet bearing glycerin and being made from the nonwoven fabric, the prescribed content of glycerin per unit area is combined with the nonwoven fabric formed of fine fibers to be employed for the top sheet. In such a top sheet, the fine fibers contribute to reduce friction on a front face of the top sheet, which, in cooperation with the friction-reducing effect of glycerin, improves the overall friction-reducing effect. In addition, retainability of glycerin is improved by the fine fibers, to thereby further improve the friction-reducing effect. Moreover, glycerin moves from the top sheet to cutis of the wearer (and in particular, penetrates through stratum corneum) so as to moisturize the cutis of the wearer (and prevent the skin dryness). Therefore, in the present disposable wearable article, a function to reduce physical irritation to the cutis of the wearer and a function to moisturize the cutis of the wearer coexist to a high degree. As a result, the present disposable wearable article has a particularly beneficial effect on the prevention of skin rash.

Note that "skin-touching region" refers to a region which is exposed on a top face of the article in its spread state.

The disposable wearable article according to the first aspect,.

The dimensions and the area ratio of the glycerin-bearing zone within the above ranges in the present aspect make the top sheet excellent in the function to reduce physical irritation to the cutis of the wearer and the function to moisturize the cutis of the wearer.

The disposable wearable article according to the first or second aspect,
wherein an amount of IL-1α secretion measured by bringing the glycerin-bearing zone (<NUM>) of the top sheet (<NUM>) into contact with a three-dimensional cultured skin model is one-half or less of that measured in a case of another sheet being different from the top sheet (<NUM>)only in that the other sheet does not bear glycerin.

IL-1α (Interleukin-1α) is proinflammatory cytokine produced in cutis which receives irritation causing skin rash (erythema). That is, the amount of IL-1α secretion measured by bringing the glycerin-bearing zone of the top sheet into contact with the three-dimensional cultured skin model is small as in the present aspect, which enables the top sheet to have an excellent ability to prevent the skin rash. Note that a method for measuring the amount of IL-1α secretion is to be discussed later.

The disposable wearable article according to any one of the first to third aspects,
wherein an amount of filaggrin measured by bringing the glycerin-bearing zone (<NUM>)of the top sheet (<NUM>) into contact with a three-dimensional cultured skin model is larger than that measured in a case of another sheet being different from the top sheet (<NUM>)only in that the other sheet does not bear the glycerin.

Filaggrin is one of main ingredients of the stratum corneum and is largely concerned with strength and flexibility of the stratum corneum. It is known that if the amount of filaggrin is insufficient, corneocytes are peeled off easily and further, transepidermal water loss (TEWL) is increased. In addition, since filaggrin is degraded to be a natural moisturizing factor (NMF), it has also a function to moisturize the stratum corneum and a function to keep pH level thereof. That is, the amount of filaggrin secretion measured by bringing the glycerin-bearing zone into contact with the three-dimensional cultured skin model is large as in the present aspect, which enables the top sheet to have an excellent ability to prevent the skin rash. Note that a method for measuring the amount of filaggrin is to be discussed later.

The disposable wearable article according to any one of first to fourth aspects,
wherein the nonwoven fabric is nonwoven fabric formed of hydrophilized fibers in which hydrophobic resin fibers have been coated with a hydrophilizer.

The nonwoven fabric for the top sheet is preferably formed of hydrophobic resin fibers for their low cost, which as they are have poor retainability of glycerin. Accordingly, in the present aspect, it is preferred to use the nonwoven fabric formed of hydrophilized fibers with a hydrophilizer to improve the glycerin-retainability of the fiber nonwoven fabric.

The present invention provides advantages such as a beneficial effect on the prevention of skin rash.

<FIG> show a tape-type disposable diaper as an example of a disposable wearable article. In the figures, reference sign X refers to the overall width of the diaper exclusive of the connecting tapes, whereas reference sign Y refers to the overall length of the diaper. In the sectional views, dotted pattern regions represent an adhesive as joining means for joining various components. A hot melt adhesive may be applied using a known technique, such as slot application, bead application in continuous lines or dotted lines, spray application in spiral, Z, or wave shapes, or pattern coating (transfer of a hot melt adhesive by relief printing). In place of or in addition to these, fixing portions of elastic members may be fixed to adjacent members by application of a hot melt adhesive to the outer peripheral surface of the elastic members. Examples of the hot melt adhesive include, but not limited to, EVA-based, pressure-sensitive rubber-based (elastomer-based), polyolefin-based, and polyester/polyamide-based adhesives. The joining means for joining various components may alternatively be material melt-bonding, such as heat sealing or ultrasonic sealing.

As the nonwoven fabric in the description hereinbelow, commonly known nonwoven fabric may suitably be used depending on the parts or purposes. Examples of the constituent fibers of the nonwoven fabric include, but not limited to, synthetic fibers, such as polyolefin-based, e.g., polyethylene or polypropylene, polyester-based, or polyamide-based fibers (including not only single component fibers, but also composite fibers, such as of core/sheath type), as well as regenerated fibers, such as rayon or cupra, or natural fibers, such as cotton, and also mixtures thereof. For improved flexibility of the nonwoven fabric, the constituent fibers may preferably be crimped fibers. The constituent fibers of the nonwoven fabric may also be hydrophilic fibers (including those rendered hydrophilic with hydrophilizers), hydrophobic fibers, or water-repelling fibers (including those rendered water-repelling with water repellents). Further, nonwoven fabric may generally be categorized into discontinuous fiber nonwoven fabric, continuous fiber nonwoven fabric, spunbonded nonwoven fabric, melt blown nonwoven fabric, spunlace nonwoven fabric, thermal bonded (air through) nonwoven fabric, needle-punched nonwoven fabric, point-bonded nonwoven fabric, composite nonwoven fabric (SSS nonwoven fabric having the same or similar nonwoven layers laid one on top of another, as well as SMS or SMMS nonwoven fabric having different nonwoven layers laid one on top of another, i.e., melt blown layer interposed between spunbonded layers), or the like, generally depending on the length of the fibers, method of forming the sheet, method of joining the fibers, or layered structure, and any of these nonwoven fabric may be used. The composite nonwoven fabric refers to those having all the layers integrally manufactured and subjected to fiber joining process all over the layers, and does not include those having a plurality of nonwoven fabric layers separately manufactured and bonded with joining means, such as hot melt adhesives.

The present tape-type disposable diaper has a ventral section F extending forward of the middle of the diaper in the front-back direction LD and a dorsal section B extending backward of the middle of the diaper in the front-back direction LD. The present tape-type disposable diaper is configured with a crotch section M extending from forward of the middle of the product to backward of the middle of the product in the front-back direction, front wings <NUM> extending on opposed sides in the right-left direction at a position spaced forward of the middle of the product in the front-back direction, and back wings <NUM> extending on opposed sides in the right-left direction at a position spaced backward of the middle of the product in the front-back direction. Further, the present tape-type disposable diaper includes an absorber body <NUM> internally disposed within a region including the crotch section, a liquid-pervious top sheet <NUM> covering the top side of the absorber body <NUM>, a liquid-impervious sheet <NUM> covering the underside of the absorber body <NUM>, and an exterior nonwoven sheet <NUM> covering the underside of the liquid-impervious sheet <NUM> to constitute the product exterior surface.

Materials and features of each part will now be explained in turn.

The absorber body <NUM> absorbs and holds excreted fluid, and may be formed of an assembly of fibers. Such an assembly of fibers may be a stack of discontinuous fibers of fluff pulp, synthetic fibers, or the like, as well as an assembly of filaments obtained by opening, where necessary, tows (fiber bundles) of synthetic fibers, such as cellulose acetate. The basis weight of the fibers may be about <NUM> to <NUM>/m<NUM> for a stack of fluff pulp or discontinuous fibers, and about <NUM> to <NUM>/m<NUM> for an assembly of filaments. The fineness of the synthetic fibers, when used, is, for example, <NUM> to <NUM> dtex, preferably <NUM> to <NUM> dtex, more preferably <NUM> to <NUM> dtex.

The plan shape of the absorber body <NUM> may suitably be decided, and may be in a rectangular shape or a shape having a middle portion in the front-back direction LD narrowed so as to fit around each leg.

The absorber body <NUM> may be caused partially or entirely to contain superabsorbent polymer particles. The superabsorbent polymer particles include not only "particles", but also "powders". Superabsorbent polymer particles used in this type of absorbent articles may be used as they are as the superabsorbent polymer particles here. The particle size of the superabsorbent polymer particles is not particularly limited and, for example, the particles may preferably have such a particle size that, when the particles are subjected to sieving (five-minute shaking) through a <NUM> standard sieve (JIS Z8801-<NUM>: <NUM>), followed by further sieving (five-minute shaking) through a <NUM> standard sieve (JIS Z8801-<NUM>: <NUM>) of the particles sieved through the previous sieve, the percentage of the particles remaining on the <NUM> standard sieve is <NUM> wt% or less and the percentage of the particles remaining on the <NUM> standard sieve is <NUM> wt% or more.

Any materials of the superabsorbent polymer particles may be used without particular limitation, and those having a water absorption of <NUM>/g or more are preferred. The superabsorbent polymer particles may be starch-based, cellulose-based, or synthetic polymer-based, and starch-acrylic acid (salt) graft copolymers, saponified products of starch-acrylonitrile copolymers, cross-linked sodium carboxymethyl cellulose, or acrylic acid (salt) polymers may be used. The superabsorbent polymer particles may preferably be in ordinary powder or granular form, but particles in other forms may also be used.

The superabsorbent polymer particles having a water absorption rate of <NUM> seconds or less, particularly <NUM> seconds or less, may preferably be used. With too slow a water absorption rate, the absorber body <NUM> is likely to undergo so-called returning, wherein liquid supplied into the absorber body <NUM> returns out of the absorber body <NUM>.

The superabsorbent polymer particles may preferably be those having a gel strength of <NUM> Pa or higher. With such property, when the superabsorbent polymer particles are formed into a bulky absorber body <NUM>, stickiness after liquid absorption may effectively be limited.

The basis weight of the superabsorbent polymer particles may suitably be decided depending on the absorption amount required in a use of the absorber body <NUM>. Thus, it depends, but the basis weight may usually be <NUM> to <NUM>/m<NUM>.

For limiting escape of the superabsorbent polymer particles, or for improving maintenance of the shape of the absorber body <NUM>, the absorber body <NUM> may be wrapped with a wrapping sheet <NUM> to produce an absorbent element <NUM>, which is to be disposed inside. The wrapping sheet <NUM> may be tissues, in particular, crepe paper, nonwoven fabric, polyethylene-laminated nonwoven fabric, perforated sheet, or the like, provided that sheets through which the superabsorbent polymer particles will not escape are preferred. When nonwoven fabric is used in place of crepe paper, hydrophilic SMMS (spunbonded/melt-blown/melt-blown/spunbonded) nonwoven fabric is particularly preferred, which may be made of polypropylene, polyethylene/polypropylene, or the like. The basis weight is preferably <NUM> to <NUM>/m<NUM>, particularly <NUM> to <NUM>/m<NUM>.

One such wrapping sheet <NUM> may be used, as shown in <FIG>, to wrap the entire absorber body <NUM>, or a plurality of sheets, such as an upper sheet and a lower sheet, may be used to wrap the entire absorber body <NUM>. Alternatively, the wrapping sheet <NUM> may be omitted.

The top sheet <NUM> extends in the front-back direction from the front end to the back end of the product, and in the width direction WD laterally beyond the absorber body <NUM>, but its shape may suitably be modified, for example, so that the width of the top sheet <NUM> is shorter than the entire width of the absorber body <NUM>, in case, for example, the starting points of standup gather parts <NUM> to be discussed later are located on the center side of the side edges of the absorber body <NUM> in the width direction WD, or otherwise required.

The top sheet <NUM> has a skin-touching region 30E that is brought into contact with skin of a wearer, and is preferably made from nonwoven fabric in light of liquid permeability and texture. Various nonwoven fabric may be used as the top sheet <NUM> but, in view of cushioning property, flexibility, permeability of loose stool (watery or muddy stool), or the like factors, discontinuous fiber nonwoven fabric, such as air-through nonwoven fabric, is preferred rather than continuous fiber (long fiber) nonwoven fabric and, usually, discontinuous fiber nonwoven fabric generally having a fineness of <NUM> to <NUM> dtex, a basis weight of <NUM> to <NUM>/m<NUM>, and a thickness of <NUM> to <NUM>, is preferred. The fiber length of the discontinuous fiber nonwoven fabric is not particularly limited, and is preferably about <NUM> to <NUM>.

The top sheet <NUM> is particularly preferably is perforated nonwoven fabric having an aperture arrayed region wherein apertures <NUM> each penetrating two sides of the fabric are arrayed in a particular pattern. The shape and size of each aperture <NUM>, the pattern of the array, or the like, may suitably be decided. Note that, in <FIG>, for ready conception of the figure, the apertures <NUM> are illustrated only in a part D of the top sheet <NUM>, which, however, does not represent the aperture arrayed region.

The aperture arrayed region may be positioned only in the middle of the top sheet <NUM> in the front-back direction LD or only in the middle of the top sheet <NUM> in the width direction WD (the top sheet <NUM> may partially have a zone without any aperture <NUM>). Alternatively, the aperture arrayed region may be provided all over the top sheet <NUM>. That is, the aperture arrayed region may extend, as long as it is provided over the skin-touching region 30E, to the other region (for example, the regions where the gathered sheets <NUM> are bonded on opposed sides in the width direction WD).

The plan shape of each aperture <NUM> (opening shape) may suitably be decided. Each aperture <NUM> may be in a slot shape as shown in <FIG>, perfect circular as shown in <FIG> as well as in <FIG> and <FIG>, elliptical as shown in <FIG>, polygonal, such as triangular, rectangular, or rhombic, start shaped, cloud shaped, or any arbitrary shape. Though not shown, apertures <NUM> of different shapes may be present. The size of each aperture <NUM> is not particularly limited, and the dimension <NUM> in the front-back direction (the maximum dimension) is preferably <NUM> to <NUM>, particularly <NUM> to <NUM>, and the dimension 14W in the width direction (the maximum dimension) is preferably <NUM> to <NUM>, particularly <NUM> to <NUM>. When the shape of each aperture <NUM> is longer in the front-back direction (the maximum dimension in one direction is longer than the overall dimension in the direction orthogonal thereto), such as a slot, elliptical, rectangular, or rhombic shape, the front-back dimension is preferably <NUM> to <NUM> times the dimension in the width direction orthogonal thereto. Further, when the shape of each aperture <NUM> is longer in one direction, the longitudinal direction of the apertures <NUM> is preferably aligned to the machine direction (MD) of the nonwoven fabric, but may be aligned to the cross direction (CD) or oblique thereto. Note that the MD of the perforated nonwoven fabric constituting the top sheet <NUM> is, in most cases, aligned to the front-back direction LD.

The area of each aperture <NUM> and the area ratio of the apertures in the aperture arrayed region may suitably be decided, and the area may preferably be about <NUM> to <NUM><NUM> and the area ratio may preferably be about <NUM> to <NUM>%.

The pattern of the array of the apertures <NUM> may suitably be decided. For example, as shown in <FIG>, it is preferred that the pattern of the array of the apertures <NUM> is a matrix wherein lines of apertures <NUM> aligned linearly in the front-back direction LD at predetermined intervals are repeated in the width direction WD at predetermined intervals. In this case, the apertures <NUM> may be arranged with the intervals 14y of the apertures <NUM> in the front-back direction LD being smaller than the intervals 14x of the apertures <NUM> in the width direction WD as shown in <FIG>, with the intervals 14y of the apertures <NUM> in the front-back direction LD being generally equal to the intervals 14x of the apertures <NUM> in the width direction WD as shown in <FIG>, or with the intervals 14y of the apertures <NUM> in the front-back direction LD being larger than the intervals 14x of the apertures <NUM> in the width direction WD as shown in <FIG>. Further, as shown in <FIG>, the lines <NUM> of apertures aligned linearly in the front-back direction LD at predetermined intervals may be arranged in the width direction WD at intervals and shifted with each other in the front-back direction LD. <FIG> show examples of the arrangement wherein the apertures <NUM> in the adjacent lines <NUM> are staggered, i.e., so-called staggered pattern (hexagonal lattice pattern).

The intervals 14y of the apertures <NUM> in the front-back direction and the intervals 14x of the apertures <NUM> in the width direction may respectively be constant or varied, which may suitably be decided. For example, the intervals 14y of the apertures <NUM> in the front-back direction may be <NUM> to <NUM>, particularly <NUM> to <NUM>, whereas the intervals 14x of the apertures <NUM> in the width direction may be <NUM> to <NUM>, particularly <NUM> to <NUM>.

The pattern of the array of apertures <NUM> may also be such that groups <NUM> of apertures <NUM> aligned in the front-back direction LD with each group forming a single wavy line <NUM>, <NUM> are arranged in the width direction WD at intervals in the same or different phases as shown in <FIG> and <FIG>. In the example of the pattern as shown in <FIG>, the wave phases of the groups <NUM> of apertures <NUM> adjacent to each other in the width direction WD are opposite, so that the imaginary lines connecting the apertures <NUM> form a Moroccan pattern (ogee pattern). In <FIG>, reference sign <NUM> refers to a unit arrayed area whereas reference sign 94W refers to the dimension in the width direction WD of the unit arrangement portion. Further, as shown in <FIG>, the pattern of the array of apertures <NUM> may also be such that groups <NUM> of apertures <NUM> aligned in the front-back direction LD at intervals with each group forming a chain-like pattern are arranged in the width direction WD at intervals. Here, "groups <NUM> of apertures <NUM> are arranged in the width direction WD at intervals" means that an imperforated zone <NUM> extending linearly unintermittently along the front-back direction LD is present between the groups <NUM> of apertures <NUM> adjacent to each other in the width direction WD.

The sectional shape of each aperture <NUM> is not particularly limited. For example, each aperture <NUM> may be a punched aperture of which periphery is formed with cut ends of fibers, or a non-punched aperture which hardly has cut ends of fibers on its periphery and is formed by inserting a pin into the space among fibers to expand (fiber density at the periphery is higher). The punched aperture may have a diameter tapered toward the middle of the thickness as shown in <FIG>, or a diameter tapered toward one end in the thickness direction, not shown.

The non-punched aperture <NUM> has a diameter tapered from the pin-insertion side toward the opposite side of the aperture <NUM>, which includes a diameter continuously tapered all over the thickness of a nonwoven fabric layer, and a diameter whose tapering is substantially ceased in the middle of the thickness. Such non-punched apertures include those as shown in <FIG> wherein fibers at the periphery of each aperture <NUM> on the side opposite to the pin-insertion side are extruded from the side opposite to the pin-insertion side to form a protrusion (burr) 14e, whereas a protrusion 14e is not formed on the pin-insertion side, and those as shown in <FIG> wherein fibers at the periphery of each aperture <NUM> on the side opposite to the pin-insertion side are extruded to the side opposite to the pin-insertion side to form a protrusion 14e, whereas fibers at the periphery of the aperture on the pin-insertion side are extruded to the pin-insertion side to form a protrusion 14e. The apertures <NUM> of the former type further include those as shown in <FIG> wherein the height <NUM> of the protrusion 14e is substantially even, and those as shown in <FIG> wherein the height 14i of the protrusion 14e is highest at two opposed locations whereas the height 14j of the protrusion 14e is lowest at two opposed locations orthogonal to the highest locations. It is preferred that the protrusion 14e continuously extends along the circumferential direction of the aperture to form a cylinder, but it is also conceivable that protrusions 14e of part or all of the apertures <NUM> are formed partially along the circumferential direction of the respective apertures <NUM>. The heights <NUM>, 14i, 14j of the protrusion (nominal height determined under optical microscope without pressure) are preferably about <NUM> to <NUM>. Further, it is preferred that the maximum height 14i of the protrusion 14e is about <NUM> to <NUM> times the minimum height 14j of the protrusion 14e. The height of protrusion 14e may vary along the circumferential direction of the aperture <NUM>.

When an aperture <NUM> longer in one direction, for example, as shown in <FIG>, is formed by pin insertion, the fibers at the periphery of the aperture <NUM> are displaced outwards or vertically to form a protrusion (burr) 14e having a height 14i at the longitudinally opposed locations of the aperture <NUM> higher than a height 14j at the opposed locations orthogonal to the longitudinal. The protrusion 14e around the aperture <NUM> may have a fiber density lower than the density around the protrusion, but preferably have a fiber density similar to or higher than the density around the protrusion.

In particular, when the perforated nonwoven fabric is continuous fiber nonwoven fabric having a fineness of <NUM> to <NUM> dtex (more preferably <NUM> to <NUM> dtex), a basis weight of <NUM> to <NUM>/m<NUM> (more preferably <NUM> to <NUM>/m<NUM>), and a thickness of <NUM> to <NUM> (more preferably <NUM> to <NUM>), and the apertures <NUM> are formed by pin insertion, the height of the protrusion 14e formed at the periphery of each aperture <NUM> is lower. More specifically, in the above-mentioned specific range of continuous fiber nonwoven fabric, the fibers are hard to be extruded in the thickness direction upon formation of the pin insertion apertures. This is because the fibers to which force is applied by the pin insertion are continuous and entangled all over the nonwoven fabric (continuous fiber), and displacement of a portion of the fibers to which force is applied by the pin insertion is withheld by the portions of the fibers continuous on the outer side thereof. Further, the above-mentioned specific range of continuous fiber nonwoven fabric basically has a moderately low fiber density, so that displacement of the fibers in the direction orthogonal to the thickness is relatively easy. As a result, when the above-mentioned specific range of continuous fiber nonwoven fabric is subjected to the pin insertion to form apertures <NUM> of the above-mentioned specific range of dimensions, during the pin insertion, the fibers around the pin are displaced toward the pin outlet side while the fibers are extruded radially outwardly of the direction of the pin insertion, which results in formation of the protrusions 14e, but with a lower height. Accordingly, at the periphery of each aperture <NUM>, a higher-density area is formed which has a fiber density higher than that of the vicinity. With such a higher-density area, the contrast between the aperture and the periphery thereof is emphasized, so that the visibility of the apertures is advantageously improved.

For the purpose of immediately transferring the liquid permeated through the top sheet <NUM> to the absorber body <NUM>, an intermediate sheet (also referred to as "second sheet") <NUM> may be provided, which has a higher liquid permeation rate compared to the top sheet <NUM>. This intermediate sheet <NUM> is for immediately transferring the liquid to the absorber body to improve the absorption performance thereof, and to prevent the "returning" phenomenon of the absorbed liquid from the absorber body <NUM>. The intermediate sheet <NUM> may be omitted.

The intermediate sheet <NUM> may be of a liquid-pervious sheet, such as nonwoven fabric. The intermediate sheet <NUM> may preferably be of air-through nonwoven fabric for its bulkiness. The air-through nonwoven fabric is preferably made of composite fibers of a core-clad structure, wherein the resin for the core may be polypropylene (PP), or preferably polyester (PET), which has a higher stiffness. The basis weight is preferably <NUM> to <NUM>/m<NUM>, more preferably <NUM> to <NUM>/m<NUM>. The fineness of the raw material fibers of the nonwoven fabric is preferably <NUM> to <NUM> dtex. For making nonwoven fabric bulky, it is also preferred to use eccentric fibers having off-centered cores, hollow fibers, or eccentric hollow fibers entirely as the raw material fibers or partially mixed fibers.

In the illustrated embodiment, the intermediate sheet <NUM> is shorter than the absorber body <NUM> in width and is arranged in the center, but may be provided over the entire width. Further, the intermediate sheet <NUM> may be provided over the entire length of the diaper, or only in the middle portion in the front-back direction LD, including the excretion area, as in the illustrated embodiment.

The liquid-impervious sheet <NUM> is not particularly limited, and may preferably have moisture-permeability. As the liquid-impervious sheet <NUM>, for example, a microporous sheet may preferably be used which is obtained by kneading an inorganic filler in a polyolefin-based resin, such as polyethylene or polypropylene, molding the kneaded mixture into a sheet, and then uni- or biaxially drawing the sheet. Alternatively, the liquid-impervious sheet <NUM> may be formed of nonwoven fabric as a base material, to which improved waterproof property is applied.

The liquid-impervious sheet <NUM> preferably extends over the same or wider extent than that of the absorber body <NUM> in the front-back direction LD and in the width direction WD but, when another liquid-shielding means is present, may not cover the ends or edges of the absorber body <NUM> in the front-back direction LD and in the width direction WD, as necessary.

The exterior nonwoven sheet <NUM> covers the entire underside of the liquid-impervious sheet <NUM> to impart a fabric-like appearance to the product exterior. The exterior nonwoven sheet <NUM> preferably has a fiber basis weight of <NUM> to <NUM>/m<NUM>, in particular <NUM> to <NUM>/m<NUM>, which, however, is not limiting. The exterior nonwoven sheet <NUM> may be omitted, in which case the liquid-impervious sheet <NUM> may extend to the side edges of the product.

It is preferred to provide standup gather parts <NUM> which stand up toward the skin of the wearer on opposed sides in the width direction WD of the top face for blocking the bodily waste moving laterally on the top sheet <NUM> and thereby preventing so-called side leakage. Naturally, the standup gather parts <NUM> may be omitted.

The standup gather parts, when employed, may be of any structure without particular limitation, and may be any of various known structures. The standup gather parts <NUM> in the illustrated embodiment are each composed of a gathered sheet <NUM> continuous substantially in the width direction WD, and elongate gathering elastic members <NUM> fixed in their stretched state to the gathered sheet <NUM> along the front-back direction LD. The gathered sheet <NUM> may be of water-repelling nonwoven fabric, whereas the gathering elastic members <NUM> may be of a rubber thread or the like. A plurality of the elastic members <NUM> may be provided on each lateral side as shown in <FIG> and <FIG>, or only one elastic member may be provided on each lateral side.

The inner face of the gathered sheet <NUM> has a joining start edge positioned on a lateral side portion of the top sheet <NUM> in the width direction WD, and the portion <NUM> outward in the width direction of this joining start edge is bonded to the inner face of the corresponding side flap SF, i.e., in the illustrate embodiment, a lateral side portion of the liquid-impervious sheet <NUM> and a lateral side portion of the exterior nonwoven sheet <NUM> located laterally outward thereof in the width direction, with a hot melt adhesive or the like.

Around each leg, each standup gather part <NUM> is fixed to the top sheet <NUM> on the center side portion <NUM> of the joining start edge in the width direction at both end portions <NUM> in the product front-back direction, while the remaining portion therebetween of the standup gather part <NUM> is a non-fixed free portion <NUM>, which will be raised by the contracting force of the elastic members <NUM> to be brought into close contact with the body surface.

The tape-type disposable diaper of the illustrated embodiment has a pair of end flaps EF, exclusive of the absorber body <NUM>, extending respectively on the front and back sides of the absorber body <NUM>, and a pair of side flaps SF, exclusive of the absorber body <NUM>, extending respectively laterally beyond the opposed sides of the absorber body <NUM>. The side flaps SF may be formed of the main body sheet (exterior nonwoven sheet <NUM> or the like) continuing from the portion containing the absorber body <NUM>, or may be formed of another material and attached.

Each side flap SF is provided with side elastic members <NUM>, which are of elongate elastic members, such as rubber threads, and are fixed in their stretched state in the front-back direction LD, to thereby form the round-leg portion of each side flap SF into a planar gather. The side elastic members <NUM> may be provided between the gathered sheet <NUM> and the liquid-impervious sheet <NUM> in the joined portion of the gathered sheet <NUM> in the outer vicinity in the width direction of the joining start edge as in the illustrated embodiment, or between the liquid-impervious sheet <NUM> and the exterior nonwoven sheet <NUM> in each side flap SF. A plurality of the side elastic members <NUM> may be provided on each lateral side as shown in the illustrated embodiment, or only one side elastic member <NUM> may be provided on each lateral side. Naturally, the side elastic members <NUM> (planar gathers) may be omitted.

The planar gathers are formed where the contracting force of the side elastic members <NUM> acts (in the illustrated embodiment, where the side elastic members <NUM> are shown). Thus, structures are conceivable, wherein the side elastic members <NUM> are present only in the area of the planar gathers, or wherein the side elastic members <NUM> are present on the front side, back side, or both of the planar gathers, but the contacting force of the side elastic members <NUM> acts only in the area of the planar gathers, while the contracting force is made not to act in the area other than the area of the planar gathers (substantially equivalent to absence of the elastic members) by finely cutting the side elastic members at one or a plurality of locations other than the area of the planar gathers, by not fixing the side elastic members <NUM> to the sheets between which the side elastic members <NUM> are interposed, or by both.

The present tape-type disposable diaper has front wings <NUM> extending on opposed sides of the product in the right-left direction at a position spaced forward of the middle of the product in the front-back direction. The front wings may be omitted (i.e., the product may be configured such that the width of the product is not varied from its narrowest portion to the front end).

The dimension of each front wing <NUM> in the width direction WD may suitably be decided and, for example, may be <NUM> to <NUM>% (in particular <NUM> to <NUM>%) the overall product length Y. The dimension of each front wing <NUM> in the width direction WD may be generally the same as the dimension of each back wing <NUM> to be discussed later in the width direction WD.

The present tape-type disposable diaper has back wings <NUM> extending on opposed sides of the product in the right-left direction at a position spaced backward of the middle of the product in the front-back direction.

The dimension of each back wing <NUM> in the width direction WD may suitably be decided and, for example, may be the same as the dimension of each front wing in the width direction WD, or smaller or larger than the dimension of the front wing in the width direction.

Each lateral edge of the product between the front wing <NUM> and the back wing <NUM> may have, for example, a generally linear portion passing the area of ±<NUM> in the width direction on both sides of and in the direction orthogonal to a line at an acute angle of ± <NUM> degrees or less with respect to the front-back direction LD. Each lateral edge of the product between the front wing <NUM> and the back wing <NUM> may extend in a wavy or arcuate manner (not shown), or in a linear manner as in the illustrated embodiment.

As in the illustrated embodiment, by cutting out each lateral side of the side flap SF in a concave shape, the overall concaved edge may be formed which extends from the lower edge of the front wing <NUM>, via the lateral edge of the product between the front wing <NUM> and the back wing <NUM>, to the lower edge of the back wing <NUM>. In this case, the layered structure of the side flaps SF decides the layered structure of the front wings <NUM> and the back wings <NUM> and, in the illustrated embodiment, the front wings <NUM> and the back wings <NUM> are formed with the gathered sheet <NUM> and the exterior nonwoven sheet <NUM>. Though not shown, a front extension sheet may be provided extending laterally from each side flap SF to form all or edge-side part of each front wing <NUM> with the front extension sheet. Similarly, a back extension sheet may be provided extending laterally from each side flap SF to form all or edge-side part of each back wing <NUM> with the back extension sheet. The front extension sheet and the back extension sheet may be of various nonwoven fabric.

Each back wing <NUM> is provided with a connecting part 13A to be detachably connected to the ventral section F when the product is worn. That is, in fitting the product, the opposed lateral side portions of the back wings <NUM> are brought onto the ventral side of the wearer, and the connecting parts 13A of the back wings <NUM> are connected to the exterior face of the ventral section F. The connecting part 13A may be a hook member (male part) of a mechanical fastener (hook and loop fastener), or a pressure-sensitive adhesive layer. The hook member has a number of engaging projections on its connecting surface, and the engaging projections may be in various known shapes, such as tick-shaped, J-shaped, mushroom-shaped, T-shaped, or doble J-shaped (wherein J-shaped parts are joined back to back).

The connecting part 13A may directly be attached to the back wing <NUM>, or a connecting tape <NUM> having the connecting part 13A may be attached to the back wing <NUM>, as in the illustrated embodiment. The structure of the connecting tape <NUM> is not particularly limited and, in the illustrated embodiment, may have a tape attachment portion 13C fixed to the side flap SF, a tape body 13B protruding from the tape attachment portion 13C, and the connecting part 13A disposed in the middle of the tape body 13B in the width direction WD, and the portion beyond this connecting part 13A is a grip portion. The sheet material forming from the tape attachment portion 13C to the tape body 13B may be nonwoven fabric, plastic film, polyethylene-laminated nonwoven fabric, paper, or composites thereof.

A connecting site on the exterior face of the ventral section F to which the connecting parts 13A are to be connected, may suitably be decided, and only the body section located between the right and left front wings <NUM> may provide the connecting site, or the areas each extending from a lateral side portion of the body section toward the proximal side of the front wing <NUM> may provide the connecting site. To such connecting site, it is preferable that the connecting parts 13A may be easily connected. For example, when the connecting parts 13A are hook members (male parts) of mechanical fasteners (hook and loop fasteners), the connecting site on the exterior face of the ventral section F may be made with a loop member (female part) <NUM> of mechanical fasteners, or nonwoven fabric. As such a loop member <NUM>, a plastic film stitched with a loop yarn is known, but in view of air permeability and flexibility, preferred is continuous fiber nonwoven fabric of which continuous fiber direction is its width direction WD (such as spunbonded nonwoven fabric generally having a fineness of <NUM> to <NUM> dtex, a basis weight of <NUM> to <NUM>/m<NUM>, and a thickness of <NUM> to <NUM>), provided with melt-bonded portions wherein fibers are melt-bonded with each other intermittently at least in the width direction WD. As in the illustrated embodiment, when a region of the exterior face of the ventral section F including the connecting site is formed with the exterior nonwoven sheet <NUM>, the hook members may be connected to the exterior nonwoven sheet <NUM> without any other means added thereto. As necessary, a loop member <NUM> may be adhered only to the connecting site on the exterior face of the ventral section F. Further, when the connecting parts 13A are in the form of pressure-sensitive adhesive layers, a plastic film having a smooth surface to be strongly adhered to the pressure-sensitive adhesive layers may be attached to the connecting site on the exterior face of the ventral section F.

The top sheet <NUM> is preferably bonded, via a hydrophobic hot melt adhesive <NUM>, to an underside member arranged on the underside of the top sheet <NUM>. Instead of or in addition to this, the top sheet <NUM> may be joined to an underside member arranged on the underside of the top sheet <NUM> by melt-bonding of at least one of the top sheet <NUM> and the underside member arranged on the underside of the top sheet <NUM>. The area in which the top sheet <NUM> is fixed may, as long as the area extends at least over the entire aperture arrayed region, only be over the aperture arrayed region or extend beyond the aperture arrayed region to other areas (e.g., all over the top sheet <NUM>). The underside member includes the intermediate sheet <NUM>, the wrapping sheet <NUM>, and the liquid-impervious sheet <NUM> in the illustrated embodiment, but is not limited thereto.

The hydrophobic hot melt adhesive <NUM> may be EVA-based, polyolefin-based, or polyester/polyamide-based adhesive or the like, and a pressure-sensitive rubber-based (elastomer-based) adhesive is particularly preferred.

The amount of the hydrophobic hot melt adhesive <NUM> to be applied may suitably be decided, and may usually be about <NUM> to <NUM>/m<NUM>. In particular, with the amount of the hydrophobic hot melt adhesive <NUM> being about <NUM> to <NUM>/m<NUM>, the hot melt adhesive <NUM> may preferably be kept from sticking out through the apertures <NUM>, but interference with glycerin in bonding as will be discussed later is likely to occur, so that it is preferred to combine the application amount with designing of the application pattern of the glycerin, or the like. The application pattern of the hydrophobic hot melt adhesive <NUM> may suitably be decided, and may preferably be a dense pattern with minute non-applied portions scattered all over (by spray application in spiral, Z, or wave shapes, or the like), or may be a continuous surface such as by slot application.

As shown in <FIG>, <FIG>, and <FIG>, the skin-touching region 30E of the top sheet <NUM> has glycerin-bearing zones <NUM> each of which bears <NUM> to <NUM>/m<NUM> of glycerin. A glycerin-bearing zone <NUM> may be provided in one site with a relatively large area, or the glycerin-bearing zones <NUM> may be provided in a plurality of sites. The glycerin-bearing zone <NUM> may be provided or may not be provided, as long as it is provided at least in the skin-touching region 30E of the top sheet <NUM>, in the other regions beyond the skin-touching region 30E.

The size, arrangement and the like of each glycerin-bearing zone <NUM> may suitably be decided, but it is not preferred that the size of the glycerin-bearing zone <NUM> is too small. Each glycerin-bearing zone <NUM> is preferred to have a MD (the front-back direction LD in the illustrated embodiment) dimension <NUM> of <NUM> or more and a CD (the width direction WD in the illustrated embodiment) dimension 32W of <NUM> or more. The MD dimension <NUM> of the glycerin-bearing zone <NUM> is more preferably <NUM> or more, further more preferably <NUM> or more, and particularly preferably <NUM> or more. The upper limit of the MD dimension <NUM> of the glycerin-bearing zone <NUM> is the overall product length Y, but may be shorter than this. The CD dimension 32W of the glycerin-bearing zone <NUM> is more preferably <NUM> or more. The upper limit of the CD dimension 32W of the glycerin-bearing zone <NUM> is the dimension in the width direction WD of the top sheet <NUM>, but may be shorter than this.

Further, with too small area of each glycerin-bearing zone <NUM> with respect to the skin-touching region 30E, a moisturizer-attaching effect to the skin and the friction-reducing effect cannot be obtained sufficiently so that an area ratio of the glycerin-bearing zone <NUM> to the skin-touching region 30E (a total area of the glycerin-bearing zones <NUM>/an area of the skin-touching region 30E is multiplied by <NUM>) is preferably <NUM>% or more, particularly preferably <NUM>% or more. Note that since the skin-touching region 30E refers to a region exposed on the top face of the article in its spread state as discussed above, if another member serves to partly hide the top sheet <NUM> (in the illustrated example, the standup gather parts <NUM> serve to hide the opposed lateral side portions of the top sheet <NUM>) in its spread state, the skin-touching region 30E refers to a region exposed on the top face exclusive of hidden portions of the article. On the other hand, when a whole top face of the top sheet <NUM> is exposed on the top face of the article, the skin-touching region 30E refers to the whole top face itself of the top sheet <NUM>.

The glycerin-bearing zones <NUM> may preferably be provided in a vertical-striped pattern as in the illustrated embodiment. Alternatively, they may be provided in a horizontal-striped pattern, dotted pattern, lattice pattern. In such cases, the intervals 32X of the adjacent glycerin-bearing zones <NUM> may suitably be decided, and may preferably be, for example, about <NUM> to <NUM>.

The nonwoven fabric for the top sheet <NUM> may preferably be nonwoven fabric having a fineness of <NUM> to <NUM> dtex (more preferably <NUM> to <NUM> dtex), a basis weight of <NUM> to <NUM>/m<NUM> (more preferably <NUM> to <NUM>/m<NUM>), and a thickness of <NUM> to <NUM> (more preferably <NUM> to <NUM>). That is, in such a nonwoven fabric, the fine fibers contribute to reducing of friction on a front face of the nonwoven fabric, which, in cooperation with the friction-reducing effect of glycerin, improves the overall friction-reducing effect. In addition, retainability of glycerin is improved by the fine fibers, to thereby further improve the friction-reducing effect. Moreover, glycerin moves from the top sheet <NUM> to cutis of the wearer (and in particular, penetrates through stratum corneum) so as to moisturize the cutis of the wearer (and prevent skin dryness). Therefore, a function to reduce physical irritation to the cutis of the wearer and a function to moisturize the cutis of the wearer coexist to a high degree. As a result, this nonwoven fabric has a particularly beneficial effect on the prevention of skin rash. More specifically, by the combination of the above nonwoven fabric and glycerin, the glycerin-bearing zones <NUM> of the top sheet <NUM> preferably have an average coefficient of friction MIU of <NUM> to <NUM>. In addition, for forming the top sheet <NUM> in this context, it is particularly preferred to use discontinuous fiber nonwoven fabric.

The surface moisture percentage of the glycerin-bearing zones <NUM> is not particularly limited, and may preferably be <NUM> to <NUM>%, particularly <NUM> to <NUM>%, for moderately moistening and keeping the skin of a wearer from drying.

In order to form the glycerin-bearing zone <NUM>, glycerin-containing hydrophilic lotion is applied to the top sheet <NUM> in a desired pattern. The hydrophilic lotion contains <NUM> to <NUM> wt% glycerin and <NUM> to <NUM> wt% water. Such a hydrophilic lotion mainly composed of glycerin with a moderate amount of water, is preferred not only as a moisturizer when transferred to the skin, but also for its hardness to decay as the water is held in the glycerin as bound water (glycerin has an extremely high water retainability). That is, for using a water-containing hydrophilic lotion in this context, it is preferred to contain a large amount of glycerin, to ensure a sufficient surface moisture percentage (e.g., <NUM> to <NUM>% as discussed above), and to keep a water activity value of the hydrophilic lotion low, for example, <NUM> or lower, more preferably <NUM> to <NUM>, particularly preferably <NUM> to <NUM>, so that, even in the absence of a preservative, development of microorganisms may be suppressed to provide improved shelf life, and the moisturizing effect upon transfer to the skin may be improved.

The hydrophilic lotion can contain one or more kinds additives selected from the group of emulsifier, phosphate ester, paraffin and surfactant. Preferable surfactant is nonionic surfactant including an ether type nonionic surfactant and an EO-PO type nonionic surfactant. For improved product shelf life, the hydrophilic lotion may contain a preservative but, as the hydrophilic lotion is to be transferred to the skin for moistening the same, it is more preferred that the hydrophilic lotion is free of preservatives.

The content of glycerin in the glycerin-bearing zone <NUM> may be suitably decided within a range of <NUM> to <NUM>/m<NUM>, and more preferably within a range of <NUM> to <NUM>/m<NUM>. For forming the glycerin-bearing zone <NUM> by applying the hydrophilic lotion, which contains <NUM> to <NUM> wt% glycerin and <NUM> to <NUM> wt% water, to the top sheet <NUM>, the application amount of the hydrophilic lotion in the glycerin-bearing zone <NUM> is about <NUM> to <NUM> /m<NUM>. When a plurality of zones 32a, 32b with different contents of the hydrophilic lotion is present as in the embodiment shown in <FIG>, or when the applied amount of the hydrophilic lotion varies gradually, as long as a portion with the content of glycerin within the above prescribed range is present in such glycerin-bearing zone <NUM>, the content of glycerin all over the glycerin-bearing zone <NUM> may be less than or more than the above prescribed range.

The content of glycerin is measured by the following measurement method.

The nonwoven fabric for the top sheet <NUM> is preferably formed of hydrophobic resin fibers for their low cost, which as they are have poor retainability of glycerin for using the water-containing hydrophilic lotion. Thus, the hydrophilic lotion preferably has a viscosity at <NUM> of <NUM> to <NUM> mPa·s. In this way, the glycerin-retainability of the nonwoven fabric is improved advantageously.

Because of the same reason, the nonwoven fabric for the top sheet <NUM> is preferably formed of hydrophilized fibers wherein hydrophobic resin fibers have been coated with a hydrophilizer. In this way, the glycerin-retainability of the nonwoven fabric is improved advantageously.

The hydrophilizer may preferably be, in consideration of safety for human body, safety in process, or the like factors, one or a mixture of nonionic activators obtained by addition of ethylene oxide to higher alcohols, higher fatty acids, alkylphenols, or the like, or anionic activators, such as alkyl phosphates (octyl or dodecyl) or alkyl sulfates. The amount to be applied may vary depending on the required performance, but may usually preferably be about <NUM> to <NUM> wt%, particularly about <NUM> to <NUM> wt% of the dry weight of the objective sheet.

Various samples of the top sheet as specified in Tables <NUM> to <NUM> were subjected to determination of various properties, including average coefficient of friction MIU, surface moisture percentage, and water activity value. The content of glycerin was measured by the measuring method as discussed above. Samples <NUM> to <NUM> were nonwoven fabric before fabrication into products, to which the hydrophilic lotion was or was not applied, and Samples <NUM> to <NUM> were top sheets removed from commercial products. Further, smoothness and moistness of each sample were perceived by stroking the top face of the top sheet in the longitudinal direction with the hand, and graded on three heights with respect to those of Sample <NUM> (⊚: excellent; Δ: better than Sample <NUM>; ×: similar).

As may be seen from Tables <NUM> to <NUM>, it was revealed that the top face of the top sheets of Samples <NUM> to <NUM> and <NUM> to <NUM>, in particular Samples <NUM> to <NUM>, <NUM>, and <NUM>, were perceived as being very smooth and moist. Compared to these, Samples <NUM> to <NUM> were inferior in smoothness and moistness. Sample <NUM> was moist but provided sticky feel.

After bringing cutis of human subjects (two males and one female in their thirties) into contact with the top sheets for one hour, respectively, the transepidermal water loss (TEWL) and the stratum corneum water content were measured in the following procedures (<NUM>) to (<NUM>). For the measurement of transepidermal water loss (TEWL), VapoMeter SWL-<NUM> manufactured by Delfin Technologies Ltd. was used as a portable water loss meter, whereas for the measurement of the stratum corneum water content, Skin Surface Hygrometer SKICON-200EX-USB manufactured by YAYOI CO. was used as a device for measuring the stratum corneum water content.

As for the stratum corneum water content, <FIG> shows a graph for comparing the results of the measurements for the four samples. In addition, as for TEWL, <FIG> shows a graph for comparing the results of the measurements for the four samples. As may be seen from these results of the measurements, it was revealed that when the (glycerin-bearing) top sheet of Sample <NUM> including the glycerin-bearing zone was used, comparing with other top sheets bearing no glycerin, moisture of the skin was hard to be escaped outside and the skin was moisturized sufficiently.

Diaper samples were prepared each having the substantially same structure as that of a tape-type disposable diaper illustrated in <FIG> and <FIG> and being provided with the (glycerin-bearing) top sheet of Sample <NUM> shown in Table <NUM>. Then, human subjects used continuously the diaper samples for one week. A doctor observed cutis conditions of these human subjects right before and right after they used the diaper samples. Note that the human subjects were thirty three healthy infants being from six months to one year old and they had usually used tape-type disposable diapers (provided with top sheets bearing no glycerin).

As a result, from finding in the observations by the doctor, problematic symptoms were not found after the observation tests. Further, although there had been seven infants having erythema before the observation tests, improvement tendencies were confirmed as for six infants among the seven infants after the observation tests.

Using a three-dimensional cultured skin model (immature model), an action of the top sheet on the production of IL-1α was evaluated as discussed below.

SkinEthic RHE-D7 (provided by EPISKIN, Inc. hereinafter referred to as RHE) was used as the three-dimensional cultured skin model. RHE was cultured for two hours in a <NUM>-well plate to be conditioned, using Growth Medium (provided by EPISKIN, Inc).

A top sheet similar to the top sheet of Sample <NUM> shown in Table <NUM> was provided. The top sheet was cut according to a surface shape of RHE (that is, circular shape with a diameter of <NUM>) into a blank test piece. Then, hydrophilic lotion having the same amount and the same composition as those of hydrophilic lotion for Sample <NUM> shown in Table <NUM> was applied to a whole surface of the blank test piece for obtaining a glycerin-bearing test piece.

The test piece was directly placed on a top face of the conditioned RHE to be acclimated thereto such that incubation was performed for <NUM> hours. In this incubation, when the first <NUM> hours had passed since the test piece was placed on RHE, the test piece was removed. Then, Growth Medium was replaced with flesh Growth Medium and successive culture was performed with a fresh test piece. The culture medium was collected such that an amount of IL-1α secretion on DAY <NUM> (the first day) was measured with an ELISA method. Further, when the next <NUM> hours had passed (in total, after <NUM> hours), the test piece was removed. Then, Growth Medium was replaced with flesh Growth Medium and successive culture was performed with a flesh test piece. The culture medium was collected and an amount of IL-1α secretion on DAY <NUM> (the second day) was measured in the same operation as in DAY <NUM>. Finally, when the last <NUM> hours had passed (in total, after <NUM> hours), the test piece was removed. Then, the culture medium was collected and an amount of IL-1α secretion on DAY <NUM> (the third day) was measured in the same operation as in DAY <NUM>. Note that RHE was collected to be used for a measurement of amount of filaggrin as will be discussed later.

Similarly, also in a case (control) where nothing was placed on the top face of RHE, an amount of IL-1α secretion was measured and RHE was collected.

The amount of IL-1α secretion was measured on each of DAY <NUM> to DAY <NUM> by quantitating the amount of IL-1α secretion in the culture medium with the sandwich ELISA method in which anti-IL-1α antibody Human IL-1α/IL-1F1 Antibody MAB200 (provided by R&D SYSTEMS, Inc. ) diluted to the appropriate concentration was used as a capture antibody and biotin-labeled anti-IL-1α antibody Human IL-1α/IL-1F1 Biotinylated Antibody BAF <NUM> (provided by R&D SYSTEMS, Inc. ) was used as a detector antibody. A detailed procedure is as follows. That is, the collected medium diluted to the predetermined concentration was added to a plate coated with the capture antibody for allowing incubation and then, the detector antibody was added. Further, Streptavidin-HRP DY998 (provided by R&D SYSTEMS, Inc. ) was added thereto to take place reaction and substrate solution Substrate Reagent Pack DY999 (provided by R&D SYSTEMS, Inc. ) was added thereto to take place reaction. Eventually, Stop Solution DY994 (provided by R&D SYSTEMS, Inc. ) was added to stop the reaction and absorbance at <NUM> was measured.

As for a total amount of secretion of IL-1α on DAY <NUM> to DAY <NUM>, as shown in <FIG>, in a case of the glycerin-bearing test piece, the amount is <NUM> ± <NUM> (pg/model), which is less than half of the amount being <NUM> ± <NUM> (pg/model) in a case of the blank test piece. Note that when the amount of IL-1α is below a detection limit, the amount is assumed to be zero.

Using a three-dimensional cultured skin model (immature model), an action of the top sheet on the amount of filaggrin was evaluated as stated below.

From a frozen block where the RHE collected in each measurement of amount of IL-1α secretion was embedded in OCT compound, a section having a thickness of <NUM> was prepared. With respect to the section adhered to a glass slide and air dried, <NUM>% Paraformaldehyde in PBS (-) was added thereto for immobilization at room temperature for <NUM> minutes and <NUM>% bovine serum albumin (BSA) in PBS (-) was added thereto for blocking at room temperature for one hour. After that, the reaction of Anti-Filaggrin Antibody (provided by Gene Tex, Inc. ) was taken place at <NUM> for one night. Then, the reaction of Anti-mouse IgG Alexa Fluor <NUM> (provided by Cell Signaling Technology, Inc. ) as the secondary antibody was taken place at room temperature for two hours. The obtained cell nucleus was stained using Hoechst <NUM> (provided by Cell Signaling Technologies, Inc. ) as counterstain and mounted with Marinol (provided MUTO PURE CHEMICALS CO. ) Thus, emitting of green fluorescence (filaggrin) and emitting of blue fluorescence (nuclei of cells) were observed with a fluorescence microscope.

As a result of the observation, as shown in <FIG>, in a case of the control, expression of filaggrin was observed in full-thickness of the stratum corneum. In a case of the blank test piece placed on the top face of the stratum corneum, the expression of filaggrin is decreased comparing with the case of control. On the other hand, in a case of the glycerin-bearing test piece placed on the top face of the stratum corneum, decrease of the expression of filaggrin was inhibited comparing with the case of the blank test piece placed thereon.

The following terms appearing in the present specification shall have the following means unless otherwise specified herein.

For example, a necessary number of specimens (for measurement and for positional identification) are provided, which have the glycerin-bearing zones <NUM> at the same positions, the glycerin-bearing zones <NUM> on the top sheet <NUM> of a specimen for positional identification are colored with an appropriate coloring agent in a color different from that of the surroundings, the colored areas are identified using a ruler or other proper image measurement device, and then the measurement is made on a specimen for measurement at the same positions as those of the colored areas identified in the specimen for positional identification, which positions are regarded as the glycerin-bearing zones <NUM>. For coloring the glycerin-bearing zones <NUM>, a water leak testing agent MORAYMILLE W manufactured by TASETO CO. may preferably be used.

In addition, when the water content of glycerin-bearing zone <NUM> reaches a certain level or more, an image of the top face of the top sheet is taken with Near-infrared Ray Camera NIRCam-<NUM> SN manufactured by Vision Sensing Co. under illumination (light in the room and outside light through the window). As a result, the glycerin-bearing zone <NUM> can be visualized (identified), due to the different color of the glycerin-bearing zone <NUM> from those of the surroundings. Thus, the size of the glycerin-bearing zone <NUM> can be measured.

In addition, when the CD dimension of a glycerin-bearing zone on the top sheet is less than the sensor dimension (<NUM>), the top sheet <NUM> is cut along the lateral edges of the glycerin-bearing zone <NUM> as shown in <FIG> to obtain a specimen <NUM> solely of the glycerin-bearing zone <NUM> (narrower in width than the sensor <NUM>), and this specimen is subjected to measurement with the center of the sensor <NUM> being aligned to the center of the specimen <NUM> in the CD as shown in <FIG>. In every measurement, glycerin remaining on the surface of the sensor <NUM> is thoroughly wiped off before next measurement.

Note that the glycerin-bearing zone <NUM> is identified by the above mentioned method.

Claim 1:
A disposable wearable article comprising a top sheet (<NUM>) having a skin-touching region (30E) that is brought into contact with skin of a wearer,
wherein the top sheet(<NUM>) is made from nonwoven fabric having a fineness of <NUM> to <NUM> dtex, and a basis weight of <NUM> to <NUM>/m<NUM> as measured in the description,
wherein the skin-touching region (30E) has a glycerin-bearing zone (<NUM>) bearing <NUM> to <NUM>/m<NUM> of glycerin, and
wherein the glycerin-bearing zone (<NUM>) is a zone where a hydrophilic lotion containing <NUM> to <NUM> wt% glycerin and <NUM> to <NUM>% wt% water has been applied at an application amount of <NUM> to <NUM>/m<NUM> , wherein the content of glycerin is measured as described in the method of the description.