Patent Description:
Publication <CIT> discloses a glucose sensor with an on-skin part and a transmitter part that can be connected to each other by a connecting port and conduction springs.

Referring to <FIG>, a conventional sensing device <NUM> disclosed in <CIT> includes a base <NUM>, an adhesive base <NUM> that is adapted for adhering the base <NUM> onto a host's skin (not shown), a biosensor <NUM> that is mounted in the base <NUM>, and a transducer <NUM> that is mounted to the base <NUM> and that is connected to the biosensor <NUM>. The biosensor <NUM> is inserted beneath the host's skin for measuring a physiological signal corresponding to the blood glucose concentration level, and the transducer <NUM> receives the physiological signal from the biosensor <NUM> and forwards the physiological signal to an external device (not shown).

Furthermore, referring to <FIG>, the biosensor <NUM> includes a fixed seat <NUM>, an elongated sensing member <NUM> that is fixedly mounted to the fixed seat <NUM>, and two contactor heads <NUM> that are fixedly mounted to the fixed seat <NUM> and that are in contact with the sensing member <NUM>. When the transducer <NUM> covers the base <NUM> to be mounted thereto, contact points (not shown) at a bottom end of the transducer <NUM> are to be in direct contact with the contactor heads <NUM> for enabling electric connection between the transducer <NUM> and the sensing member <NUM>. However, as the transducer <NUM> and the sensing members <NUM> are spaced apart in a coupling direction while the contactor heads <NUM> extends in the same direction for enabling the electric connection therebetween, the thickness of each of the contactor heads <NUM> (length in the coupling direction) cannot be smaller than the distance between the transducer <NUM> and the sensing member <NUM>. As such, minimum thickness restriction to the contactor heads <NUM> made it difficult to reduce the overall thickness of sensing device <NUM>. In addition, the contactor heads <NUM> may not be able to properly enable electric connection between the biosensor <NUM> and the transducer <NUM> due to manufacturing errors, such as misalignment of the contactor heads <NUM>, or the contactor heads <NUM> having the thickness different from the distance between the transducer <NUM> and the sensing member <NUM>.

Therefore, an object of the disclosure is to provide a physiological signal monitoring device that can alleviate the drawbacks of the prior art.

According to the disclosure, the physiological signal monitoring device is for sensing a physiological signal in an analyte of a host, and includes a sensing member and a transmitter. The sensing member includes a signal sensing end adapted to be inserted underneath a skin of the host to sense the physiological signal, and a signal output end for outputting the physiological signal. The transmitter is connected to the sensing member for receiving, processing and transmitting the physiological signal, and includes a circuit board and a connecting port. The circuit board has a plurality of electrical contacts. The connecting port is connected to the circuit board and has a socket which is communicated to the circuit board, and a plurality of conducting springs which are received within the connecting port. The conducting springs are disposed at two opposite sides of the socket. The sensing member is removably inserted into the socket. Each of the conducting springs has one side electrically connected to a respective one of the electrical contacts of the circuit board and another side electrically connected to the signal output end of the sensing member for electric connection between the respective one of the electrical contacts and the signal output end. Each of the conducting springs is frictionally rotated by the sensing member during insertion of the sensing member into the socket and removal of the sensing member from the socket.

Other features and advantages of the disclosure will become apparent in the following detailed description of the embodiment with reference to the accompanying drawings, of which:.

In addition, in the description of the disclosure, the terms "up", "down", "top", "bottom" are meant to indicate relative position between the elements of the disclosure, and are not meant to indicate the actual position of each of the elements in actual implementations. Similarly, various axes to be disclosed herein, while defined to be perpendicular to one another in the disclosure, may not be necessarily perpendicular in actual implementation.

Referring to <FIG>, a first embodiment of the physiological signal monitoring device according to the disclosure is adapted to be mounted to a skin surface of a host (not shown), and is adapted for measuring at least one analyte of the host and for sending a corresponding type of physiological signal. In this embodiment, the physiological signal monitoring device is for measuring the blood glucose concentration in the interstitial fluid (ISF) of the host, and is meant to be mounted to the skin surface for two weeks, but is not restricted to such.

Referring back to <FIG> and <FIG>, the physiological signal monitoring device includes a base <NUM> that is adapted to be mounted to the skin surface of the host, a biosensor <NUM> that is mounted to the base <NUM> and that is adapted to be partially inserted underneath the skin surface of the host, and a transmitter <NUM> that covers and is removably coupled to the base <NUM> in a direction of a first axis (D1) and that is connected to the biosensor <NUM>. The biosensor <NUM> is adapted for measuring at least one analyte of the host and for sending a corresponding physiological signal to the transmitter <NUM>, while the transmitter <NUM> receives, processes, and outputs the physiological signal to an external device (not shown) for monitoring purposes. When the physiological signal monitoring device is to be replaced after a prolonged period of use, the transmitter <NUM> is permitted to be separated from the biosensor <NUM> and the base <NUM> to be reused with a new set of the base <NUM> and biosensor <NUM>.

The base <NUM> includes a base body <NUM>, and an adhesive pad <NUM> that is mounted to a bottom surface <NUM> (see <FIG>) of the base body <NUM> and that is permitted for attaching the base body <NUM> to the skin surface of the host. The biosensor <NUM> includes a fixed seat <NUM> that is mounted to the base body <NUM>, and a sensing member <NUM> that is mounted to the fixed seat <NUM> and that extends through the base body <NUM>. The fixed seat <NUM> is mounted between the transmitter <NUM> and the base <NUM> when the transmitter <NUM> is coupled to the base <NUM>.

The fixed seat <NUM> has a bottom surface <NUM> and a top surface <NUM>. The sensing member <NUM> has a signal sensing end <NUM> that is adapted to be inserted underneath the skin surface of the host for measuring the physiological signal of the host, and a signal output end <NUM> that is adapted to output the physiological signal received from the signal sensing end <NUM>. The signal sensing end <NUM> protrudes from the bottom surface <NUM> of the fixed seat <NUM>, and the signal output end <NUM> protrudes from the top surface <NUM> of the fixed seat <NUM>.

Referring to <FIG> and <FIG>, the sensing member <NUM> includes a base board <NUM>, a plurality of electrodes <NUM> mounted to a surface of the base board <NUM>, and an analyte sensing layer (not shown) that covers the electrodes <NUM> and the surface of the base board <NUM>. The analyte sensing layer is provided for reacting with the at least one analyte of the host, and the electrodes <NUM> includes signal receiving electrodes that detect outcome of the reaction, and signal sending electrodes that generate an electric signal indicating the outcome of the reaction. In this embodiment, the electric signal is the physiological signal that indicates glucose levels in the interstitial fluid. Specific roles of the electrodes <NUM> will be elaborated later.

Referring back to <FIG>, <FIG> and <FIG>, the transmitter <NUM> includes a bottom casing <NUM> that is proximate to the base body <NUM>, a top casing <NUM> that is mounted to the bottom casing <NUM> to define an inner space <NUM>, a circuit board <NUM> that is disposed in the inner space <NUM>, a processing unit <NUM> (see <FIG> and <FIG>) that is mounted to the circuit board <NUM>, a battery <NUM> that is disposed in the inner space <NUM>, and a connecting port <NUM> that is connected to a bottom surface of the circuit board <NUM> and that extends outwardly from the inner space <NUM> toward the base body <NUM>.

The circuit board <NUM> is permitted to be printed circuit board (PCB) or flexible print circuit (FPC), and is fixedly positioned to the bottom casing <NUM> via a supporting member <NUM>, which may be made of a metal plate. The circuit board <NUM> has a plurality of electrical contacts <NUM> that correspond in position to the connecting port <NUM>. In this embodiment, the number of the electrical contacts <NUM> is eight. The processing unit <NUM> is provided for receiving, processing, and sending the physiological signal, and is connected to the electrical contacts <NUM>. The battery <NUM> is connected to the electrical contacts <NUM> of the circuit board <NUM>.

Referring back to <FIG>, <FIG> and <FIG>, the connecting port <NUM> includes a port casing <NUM> that is mounted to a bottom surface of the circuit board <NUM> and that extends downwardly toward a bottom surface <NUM> of the bottom casing <NUM> in the direction of the first axis (D1), and a plurality of spaced-apart conducting members <NUM> that are received within the port casing <NUM>. In this embodiment, the number of the conducting members <NUM> is eight.

The port casing <NUM> is formed with a plurality of grooves <NUM> open toward the circuit board <NUM> and respectively receiving the conducting members <NUM> therein, and a socket <NUM> that extends toward the base body <NUM> in the direction of the first axis (D1) and that is communicated to the grooves <NUM>. The conducting members <NUM> are respectively and rotatably received within the grooves <NUM>. The socket <NUM> is provided to hold the signal output end <NUM> of the sensing member <NUM>.

Referring back to <FIG> and <FIG>, in a modification of the first embodiment, a cross section of an outer periphery of the grooves <NUM> perpendicular to the first axis (D1) is substantially dovetail-shaped, and each of the grooves <NUM> tapers toward the socket <NUM> for preventing each of the conducting members <NUM> from escaping the respective one of the grooves <NUM>.

The conducting members <NUM> are elastic, and are disposed at two opposite sides of the socket <NUM>. In this embodiment, the conducting members <NUM> are conducting coil springs. Each of the conducting members <NUM> contacts with the circuit board <NUM> at one side along with a first direction, and contacts with the sensing member <NUM> at another side along a second direction wherein the first direction is nonparallel to the second direction. Therefore, the electric connection between the electrical contacts <NUM> of the circuit board <NUM> and the signal output end <NUM> of the sensing member <NUM> is provide when the sensing member <NUM> is inserted into the socket <NUM>. Specifically, each of the conducting members <NUM> has one side that is in contact with (and electrically connected to) a respective one of the electrical contacts <NUM> of the circuit board <NUM> in the direction of the first axis (D1) (i.e., the first direction) and another side that is in contact with (and electrically connected to) the electrodes <NUM> on the signal output end <NUM> of the sensing member <NUM> in a direction of a second axis (D2) (i.e., the second direction) for positioning the sensing member <NUM> when it is inserted into the socket <NUM> and for enabling electric connection between the electrical contacts <NUM> of the circuit board <NUM> and the signal output end <NUM> of the sensing member <NUM>. In this embodiment, the first and second axes (D1, D2) are substantially perpendicular to each other, but may not be restricted as such in other embodiments. The conducting coil springs have high degrees of freedom such that each of the conducting members <NUM> is rotated relative to the grooves <NUM> during insertion of the sensing member <NUM> into the socket <NUM> and removal of the sensing member <NUM> from the socket <NUM> along the first axis (D1), thereby reducing friction between the socket <NUM> and the sensing member <NUM> and facilitating the reuse of the transmitter <NUM>.

It should be noted that, in this embodiment, each of the conducting members <NUM> has one end welded to the port casing <NUM> so that one end of each of the conducting members <NUM> is fixed on the respective one of the grooves <NUM>. In addition, as the conducting members <NUM> are conducting coil springs, each of the conducting members <NUM> has the following properties: the wire diameter thereof is smaller than <NUM> millimeter (mm), preferably <NUM>; the outer diameter thereof ranges from <NUM> to <NUM>, preferably <NUM>; the free length thereof ranges from <NUM> to <NUM>, preferably <NUM> to <NUM>. Each of the conducting members <NUM> has a helical portion 365a with two to six turns (three turns in this embodiment), thereby providing multi-point contacts with the respective one of the electrical contacts <NUM> of the circuit board <NUM> and the signal output end <NUM> of the sensing member <NUM>. It should be noted that, parameters such as the wire diameter and the number of turns of each of the conducting members <NUM> are designed in consideration to the elasticity of the conducting members <NUM>, and the outer diameter and the free length of each of the conducting members <NUM> are designed in such a way that each of the conducting members <NUM> is slightly larger than a space of the respective one of the grooves <NUM>, so that the conducting members <NUM> are in stable contact with the electrical contacts <NUM> of the circuit board <NUM> and the electrodes <NUM> on the signal output end <NUM> of the sensing member <NUM>(see <FIG> and <FIG>).

Referring to <FIG>, in another modification of the first embodiment, the conducting members <NUM> of the connecting port <NUM>, which were originally conductive coil springs in the first embodiment, are steel balls or steel rings (i.e., rigid components) instead. In addition, the connecting port <NUM> further includes a plurality of elastic members <NUM>, each of which is mounted in the respective one of the grooves <NUM> and is mounted between the port casing <NUM> and a respective one of the conducting members <NUM>. The elastic members <NUM> are made of elastic materials such as rubber, and each of the conducting members <NUM> has one side contacted with the respective elastic member <NUM> and another side contacted with the electrodes <NUM> of the the signal output end <NUM> along an axis parallel to the second axis (D2). Overall, the conducting members <NUM> in this modification functions similarly to that of the first embodiment: enabling electric connection between the electrical contacts <NUM> and the signal output end <NUM>, and being frictionally moved by the sensing member <NUM> to rotate in the grooves <NUM>. The elastic members <NUM> ensure that the conducting members <NUM> are in stable contact with the sensing member <NUM> and the circuit board <NUM> along the directions parallel to the first axis (D1) and the second axis (D2) respectively.

Referring to <FIG>, in yet another modification of the first embodiment, the conducting members <NUM> are conducting coil strings, each of which has an extended section 365b that extends along an inner surface of the port casing <NUM> toward the circuit board <NUM>, and that is connected to the respective one of the electrical contacts <NUM> in the direction of the first axis (D1).

Referring to <FIG> and <FIG>, in the first embodiment, the processing unit <NUM> receives the electric signal from the sensing member <NUM> and sends a corresponding physiological signal. The processing unit <NUM> includes a signal amplifier <NUM> receiving and amplifying the electric signal, a measuring and computing module <NUM> that converts the amplified electric signal sequentially into a physiological signal corresponding to the glucose level, and a transmitting module <NUM> that sends the physiological digital signal to an external device (not shown) via an antenna <NUM>. It should be noted that, in the disclosure, the abovementioned physiological signal corresponding to the glucose level is electric current.

As previously mentioned, the number of the conducting members <NUM> is eight in this embodiment. The conducting members <NUM> are conducting coil springs and include two power-supplying conducting members 364a, four sensing conducting members 364b, and two transmitting conducting members 364c. The electrodes <NUM> of the sensing member <NUM> are in contact with the conducting members <NUM> to be respectively and electrically connected to the electrical contacts <NUM> of the circuit board <NUM> for the purposes of supplying power, sensing and transmitting data.

The power-supplying conducting members 364a and the electrodes <NUM> cooperatively form a switch. The sensing conducting members 364b are connected to the processing unit <NUM>. The transmitting conducting members 364c are connected to the processing unit <NUM> as well, and transmit data to the external device via the transmitting module <NUM> and the antenna <NUM>. In this embodiment, type of data transmission may be wireless transmission (Bluetooth, Wifi, NFC), but may be wired transmission (USB cable) in other embodiments.

In this embodiment, the number of the electrodes <NUM> of the sensing member <NUM> is five. The electrodes <NUM> include a working electrode 226a, a reference electrode 226b, a power-supplying electrode 226e, and two electrical contact sections 226d.

When the sensing member <NUM> is not inserted into the socket <NUM> of the connecting port <NUM>, the switch formed by the conducting members 364a is in an open circuit state, so that the battery <NUM> is in a non-power supplying state.

When the sensing member <NUM> is inserted into the socket <NUM>, the power-supplying electrode 226e of the sensing member <NUM> is in contact with the power-supplying conducting members 364a to be electrically connected with the electrical contacts <NUM> of the circuit board <NUM>, such that the switch is in a closed circuit state and the battery <NUM> is switched to a power supplying state for supplying power to the sensing member <NUM> and the processing unit <NUM> for performing measurement of the analyte. At the same time, each of the working and reference electrode 226a, 226b is in contact with corresponding two of the sensing conducting members 364b to be electrically connected to the electrical contacts <NUM> of the circuit board <NUM>, such that the processing unit <NUM> receives, processes, and sends the physiological signal to the external device. The electrical contact sections 226d are permitted to be respectively and electrically connected to the transmitting conducting members 364c. In this embodiment, the electrical contact sections 226d has signal receiving and signal sending electrodes.

A circuit layout of the transmitter <NUM> can be modified according to the various requirement of the product. For example, referring to <FIG>, the sensing member <NUM> begins measurement of the physiological signal of the host without power control by the processing unit <NUM> when the sensing member <NUM> is inserted into the socket <NUM>. The circuit concerning to the power supply can be rearranged in other embodiments, so there is no more detailed description herein.

In addition, the socket <NUM> of the connecting port <NUM> is further adapted for additional transmission device (not shown) or charging device (not shown) to be inserted thereinto. For example, after the transmitter <NUM> is manufactured (before being connected to the biosensor <NUM> and the base <NUM>), a connector (or an electrode) of the additional transmission device may be inserted into the socket <NUM> to provide electric connection and data transmission between the processing unit <NUM> and the additional transmission device through the transmitting conducting members 364c. In other words, in this embodiment, the transmitting conducting members 364c are permitted to be electrically connected to the additional transmission device for exchanging data (default data or calibration data) before the transmitter <NUM> is connected to the biosensor <NUM> and the base <NUM>. Furthermore, when the transmitter <NUM> is uncoupled from the biosensor and the base <NUM> for repeated use, the charging device may be inserted into the socket <NUM> to recharge the transmitter <NUM> through the power-supplying conducting members 364a, which electrically interconnect the electrical contacts <NUM> of the circuit board <NUM> and the charging device.

Referring to <FIG>, in another modification of the sensing member <NUM> and the socket <NUM> of the first embodiment, the electrodes <NUM> of the sensing member <NUM> include a working electrode 226a, a counter electrode 226f, a power-supplying electrode 226e, and two electrical contact sections 226d, and the number of the conducting members <NUM> of the transmitter <NUM> is six. The conducting members <NUM> are conducting coil springs and include two power-supplying conducting members 364a, two sensing conducting members 364b, and two transmitting conducting members 364c. When the sensing member <NUM> is inserted into the socket <NUM> of the connecting port <NUM>, the power-supplying electrode 226e of the sensing member <NUM> is in contact with the power-supplying conducting members 364a to be electrically connected with the electrical contacts <NUM> of the circuit board <NUM>. At the same time, each of the working and counter electrode 226a, 226f is in contact with a respective one of the sensing conducting members 364b to be electrically connected to the electrical contacts <NUM> of the circuit board <NUM>, such that the processing unit <NUM> receives, processes, and sends the physiological signal to the external device. The electrical contact sections 226d are permitted to be respectively and electrically connected to the transmitting conducting members 364c.

Referring to <FIG>, in yet another modification of the sensing member <NUM> and the socket <NUM> of the first embodiment, the electrodes <NUM> of the sensing member <NUM> include a working electrode 226a, a counter electrode 226f, and two power-supplying electrodes 226e, and the number of the conducting members <NUM> of the transmitter <NUM> is four. The conducting members <NUM> are conducting coil springs and include two power-supplying conducting members 364a and two sensing conducting members 364b. When the sensing member <NUM> is inserted into the socket <NUM> of the connecting port <NUM>, the power-supplying electrodes 226e of the sensing member <NUM> are respectively in contact with the power-supplying conducting members 364a to be electrically connected with the electrical contacts <NUM> of the circuit board <NUM>. At the same time, each of the working and counter electrode 226a, 226f is in contact with a respective one of the sensing conducting members 364b to be electrically connected to the electrical contacts <NUM> of the circuit board <NUM>, such that the processing unit <NUM> receives, processes, and sends the physiological signal to the external device.

By utilizing the abovementioned modifications of the sensing member <NUM> and the socket <NUM> of the first embodiment, the electrical contacts <NUM> of the circuit board <NUM> and the electrodes <NUM> of the sensing member <NUM> are able to be electrically connected to activate the processing unit <NUM>. It should be noted that the conducting coil springs in the abovementioned modifications may be conducting components of other forms.

In the above embodiments, the transmitter <NUM> is coupled to the biosensor <NUM> assembled on the base <NUM> wherein the base <NUM> is attached on the host skin. Accordingly, the sensing member <NUM> of the biosensor <NUM> is inserted into the socket <NUM> of the transmitter <NUM> for the measurement of the analyte.

Overall, the first embodiment of the physiological signal monitoring device provides the following benefits:.

<FIG> and <FIG> illustrate a second embodiment of the physiological signal monitoring device wherein the difference between the first embodiment and the second embodiment is described as follows.

The port casing <NUM> of the connecting port <NUM> has a plurality of slanted surfaces <NUM> respectively disposed in the grooves <NUM> and facing the circuit board <NUM> and the sensing member <NUM>. Therefore, the conducting members <NUM> are forced against the circuit board <NUM> and the sensing member <NUM> with force vector provided by the slanted surfaces <NUM> to ensure the contact therebetween and enhance the mobility of the conducting members <NUM>. Moreover, the conducting members <NUM> could return to the predetermined position after the removal of the sensing member <NUM> from the socket <NUM> because of the slanted surfaces <NUM> such that the contact problem resulting in electric disconnection between the conducting member <NUM> and the sensing member <NUM> could be solved. In other embodiments, the conducting members <NUM> could be modified as hard components(ex. steel ball or steel ring) with the elastic members <NUM> configured between the conducting members <NUM> and the slanted surfaces <NUM>.

<FIG> illustrates a third embodiment of the physiological signal monitoring device wherein the difference between the first embodiment and the third embodiment is described as follows.

In this embodiment, each of the conducting members <NUM> of the connecting port <NUM> is a leaf spring with one end contacted with the corresponding electrical contact <NUM> of the circuit board <NUM> along the first axis (D1) and another end contacted with the electrodes <NUM> of the sensing member <NUM> along the second axis (D2). Accordingly, the sensing member <NUM> is stably held within the socket <NUM> by the leaf springs <NUM> to provide reliable electric connection and signal transmission between the circuit board <NUM> and the sensing member <NUM>.

<FIG> illustrates a fourth embodiment of the physiological signal monitoring device wherein the difference between the first embodiment and the fourth embodiment is described as follows.

The conducting members <NUM> are conducting coil springs. The connecting port <NUM> further includes a plurality of metal plates <NUM> respectively connected to the electrical contacts <NUM>. In this embodiment, the metal plates <NUM> are welded to the electrical contacts <NUM> via surface mount technology (SMT), and extended toward the grooves <NUM> to be disposed between the port casing <NUM> and the conducting members <NUM>. Therefore, each of the conducting members <NUM> coaxially contacted with a respective one of the metal plates <NUM> and the electrodes <NUM> of the sensing member <NUM> along an axis parallel to the second axis (D2) to provide reliable electric connection between the circuit board <NUM> and the sensing member <NUM>.

<FIG> and <FIG> illustrate other modifications of the fourth embodiment, in which the conducting members <NUM> are steel balls or steel rings instead wherein the metal plates <NUM> are welded to the electrical contacts <NUM> via surface mount technology (SMT) shown as <FIG> or dual in-line package (DIP) shown as <FIG>.

It should be noted that in the abovementioned embodiments, the conducting members <NUM> of the connecting port <NUM> are disposed at two opposite sides of the socket <NUM>. However, in other embodiments, the conducting members <NUM> of the connecting port <NUM> can be disposed at single side of the socket <NUM> instead, such that only single side of the sensing member <NUM> is abutted against the conducting members <NUM>. Referring to <FIG> and <FIG>, the sensing member <NUM> is stably held within the socket <NUM> by the elastic conducting members <NUM> and the port casing <NUM> to provide reliable electric connection between the circuit board <NUM> and the sensing member <NUM>.

Consequently, the conducting members <NUM> are lateraly configured at the socket <NUM> to contact with the electrodes <NUM> of the sensing member <NUM> and the electrical contacts <NUM> of the circuit board <NUM> after the transmitter <NUM> is coupled to the biosensor <NUM>, thereby providing the reliable electric connection therebetween and holding of the sensing member <NUM>. Moreover, the conducting members <NUM> are rotated relative to the grooves <NUM> during insertion or removal of the sensing member <NUM> from the socket <NUM> to reduce friction resistance between conducting members <NUM> and the sensing member <NUM> and facilitate the reuse of the transmitter <NUM>. In addition, the conducting members <NUM> can be conducting coil springs, steel balls/rings with the elastic members <NUM> or metal plates <NUM> to provide bidirectional or coaxial connection between the sensing member <NUM> and the circuir board <NUM>. Therefore, the electrodes <NUM> of various functions are electrically connected with the electrical contacts <NUM> of single connecting port <NUM> to activate the power supply, signal sensing and date transmission.

Claim 1:
A physiological signal monitoring device for sensing a physiological signal in an analyte of a host, comprising:
a sensing member (<NUM>), including
a signal sensing end (<NUM>) adapted to be inserted underneath a skin of the host to sense the physiological signal, and
a signal output end (<NUM>) for outputting the physiological signal; and
a transmitter (<NUM>) connected to said sensing member (<NUM>) for receiving, processing and transmitting the physiological signal, said physiological signal monitoring device characterized in that said transmitter (<NUM>) includes
a circuit board (<NUM>) having a plurality of electrical contacts (<NUM>), and
a connecting port (<NUM>) connected to said circuit board (<NUM>) and having a socket (<NUM>) which is communicated to said circuit board (<NUM>), and a plurality of conducting springs (<NUM>) which are received within said connecting port (<NUM>);
wherein, said sensing member (<NUM>) is removably inserted into said socket (<NUM>);
wherein, each of said conducting springs (<NUM>) has one side electrically connected to a respective one of said electrical contacts (<NUM>) of said circuit board (<NUM>) and another side electrically connected to said signal output end (<NUM>) of said sensing member (<NUM>) for electric connection between the respective one of said electrical contacts (<NUM>) and said signal output end (<NUM>); and
wherein, each of said conducting springs (<NUM>) is frictionally rotated by said sensing member (<NUM>) during insertion of said sensing member (<NUM>) into said socket (<NUM>) and removal of said sensing member (<NUM>) from said socket (<NUM>).