Patent Description:
Conventionally, it has been reported that fluorine-containing pyrimidine compounds have various biological activities. Among others, a compound having a pyridine ring structure or diazine ring structure at the <NUM>-position of its pyrimidine ring is promising for use in pharmaceutical and agrochemical fields.

More specifically, a compound having a pyridine ring at the <NUM>-position of its pyrimidine ring and having a trifluoromethyl group at the <NUM>-position of its pyrimidine ring is disclosed in Patent Literatures <NUM> to <NUM>. Patent Literatures <NUM> and <NUM> report that a <NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine derivative has a human melanin-concentrating hormone-inhibiting activity and an acetyl-CoA carboxylase <NUM>-inhibiting activity. Patent Literatures <NUM> to <NUM> report that a <NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine derivative has a disinfecting activity, an insecticidal activity, an orexin receptor-inhibiting activity, a focal adhesion kinase-inhibiting activity, and an acetyl-CoA carboxylase <NUM>-inhibiting activity. Patent Literatures <NUM> and <NUM> report that a <NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine derivative has a disinfecting activity, an insecticidal activity, and an herbicide activity. From such viewpoints, in expectation of further improvement in activities, introduction of substituents into the <NUM>- and <NUM>-positions of a pyrimidine ring receives interest.

In addition, a compound having a diazine ring structure at the <NUM>-position of its pyrimidine ring is disclosed Patent Literatures <NUM> and <NUM> to <NUM>. Patent Literature <NUM> discloses disinfecting and insecticidal activities of a compound having a <NUM>-(<NUM>-pyrazyl)-pyrimidine structure or <NUM>-(<NUM>-pyrimidyl)-pyrimidine structure, Patent Literature <NUM> discloses a suppressing activity of a compound having a <NUM>-(<NUM>-pyridazyl)-pyrimidine structure or <NUM>-(<NUM>-pyrazyl)-pyrimidine structure against fibrotic diseases, Patent Literature <NUM> discloses suppressing activities of a compound having a <NUM>-(<NUM>-pyrimidyl)-pyrimidine structure or <NUM>-(<NUM>-pyrimidyl)-pyrimidine structure against pain and asthma, and Patent Literature <NUM> discloses suppressing activities of a compound having a <NUM>-(<NUM>-pyridazyl)-pyrimidine structure against aching pain and asthma. Patent Literature <NUM> discloses pyrimidine derivatives with fungicidal activity.

A synthesis method of a pyrimidine compound having a trifluoromethyl group at the <NUM>-position and having substituents at the <NUM>- and <NUM>-positions of its pyrimidine ring is disclosed in Non Patent Literatures <NUM> to <NUM>. More specifically, Non Patent Literature <NUM> reports a synthesis method using sodium trifluoromethanesulfinate (Langlois reagent), Non Patent Literature <NUM> reports a synthesis method using a trifluoroacetic acid derivative, and Non Patent Literature <NUM> reports a synthesis method using trifluoromethanesulfonic anhydride.

However, manufacturing of a fluorine-containing pyrimidine compound having a fluorine-containing substituent at the <NUM>-position, having a heterocyclic ring at the <NUM>-position as a substituent, and having substituents at the <NUM>- and <NUM>-positions has been hitherto difficult in terms of reactivity and selectivity, and such a fluorine-containing pyrimidine compound has not been reported. The fluorine-containing pyrimidine compound is expected to have various biological activities, and a new fluorine-containing pyrimidine compound having substituents at the <NUM>- and <NUM>-positions and having a heterocyclic ring at the <NUM>-position as a substituent and a manufacturing method thereof have been desired to be established.

Since regioselectivity at the time of introducing trifluoromethyl group is low in the manufacturing methods reported in Non Patent Literature <NUM>, introduction efficiency of trifluoromethyl group may decrease or introduction of trifluoromethyl group may become difficult with respect to a substrate having a plurality of heterocyclic rings such as a pyrimidine compound having a heterocyclic ring substituent. In addition, there has been a problem of not only using Langlois reagent as a trifluoromethylating agent in an amount of three times the amount of a substrate but also separately using manganese (III) acetate hydrate, which is toxic, as an oxidant in an amount of three times the amount of the substrate.

It is thought that a compound obtained by the manufacturing methods reported in Non Patent Literatures <NUM> and <NUM> is further modified and derivatized to be converted to the fluorine-containing pyrimidine compound. However, complication or a decrease in efficiency due to an increase in the number of processes cannot be sometimes avoided, or manufacturing of the fluorine-containing pyrimidine compound itself is sometimes difficult. In addition, these manufacturing methods are not considered to be suitable for practical use because a trifluoromethylating agent is required to be used in an amount of <NUM> to <NUM> times the amount of a substrate and light irradiation in the presence of a ruthenium complex catalyst is required.

Then, the present inventors have found that a pyridine ring structure or a diazine ring structure can be introduced into the <NUM>-position between two nitrogen atoms on a pyrimidine ring by reacting specific raw materials and completed the present invention thereby. That is, the present invention aims at providing a new fluorine-containing pyrimidine compound having substituents at the <NUM>- and <NUM>-position and having a pyridine ring structure or a diazine ring structure at the <NUM>-position as a substituent and a manufacturing method capable of simply manufacturing the fluorine-containing pyrimidine compound, which are heretofore unknown.

Purports and configurations of the present invention are as follows.

A new fluorine-containing pyrimidine compound having substituents at the <NUM>- and <NUM>-position and having a pyridine ring structure or a diazine ring structure at the <NUM>-position as a substituent and a manufacturing method capable of simply manufacturing the fluorine-containing pyrimidine compound can be provided.

A fluorine-containing pyrimidine compound according to one embodiment is represented by general formula (<NUM>), (<NUM>), (<NUM>), (<NUM>), (<NUM>), or (<NUM>) below. <CHM>
(In the general formulae (<NUM>) to (<NUM>) above,.

R is not particularly limited as long as R is a hydrocarbon group consisting of carbon atoms and hydrogen atoms, having <NUM> to <NUM> carbon atoms; and R can include a chain hydrocarbon group, an aromatic hydrocarbon group, an alicyclic hydrocarbon group, and the like. The chain hydrocarbon group is not particularly limited as long as it has <NUM> to <NUM> carbon atoms in total and may be a branched chain hydrocarbon group or may be a non-branched chain hydrocarbon group. The aromatic hydrocarbon group is not particularly limited as long as it has <NUM> to <NUM> carbon atoms in total and may be an aromatic hydrocarbon group having a substituent or may be an aromatic hydrocarbon group having no substituent. In addition, the aromatic hydrocarbon group may have a condensed polycyclic structure. The alicyclic hydrocarbon group is not particularly limited as long as it has <NUM> to <NUM> carbon atoms in total and may be an alicyclic hydrocarbon group having a substituent or may be an alicyclic hydrocarbon group having no substituent. In addition, the alicyclic hydrocarbon group may have a bridged cyclic structure.

The chain hydrocarbon group can include an alkyl group such as methyl group, ethyl group, n-propyl group, i-propyl group, n-butyl group, i-butyl group, sec-butyl group, t- butyl group, pentyl group, hexyl group, heptyl group, octyl group, nonyl group, decyl group, undecyl group, and dodecyl group;.

The aromatic hydrocarbon group can include phenyl group and naphthyl group.

The alicyclic hydrocarbon group includes a saturated or unsaturated cyclic hydrocarbon group, and examples of the cyclic hydrocarbon group can include a cyclopropyl group, cyclobutyl group, cyclohexyl group, cyclopentyl group, adamantyl group, norbornyl group, and the like.

Preferably, R is an alkyl group having <NUM> to <NUM> carbon atoms. When R is an alkyl group having <NUM> to <NUM> carbon atoms, the fluoroisobutylene derivative of general formula (<NUM>) and the fluoroisobutane derivative of general formula (<NUM>), which are raw materials of the fluorine-containing pyrimidine compound, can be easily prepared.

A<NUM> included in -OA<NUM> and -SOmA<NUM> (m is an integer of <NUM> to <NUM>) represented as X or Y represents a hydrogen atom or a hydrocarbon group having <NUM> to <NUM> carbon atoms. A<NUM> and A<NUM> included in -NA<NUM>A<NUM> represented as X or Y each independently represent a hydrogen atom or a hydrocarbon group having <NUM> to <NUM> carbon atoms. In a case where A<NUM> and A<NUM> represent a hydrocarbon group having <NUM> to <NUM> carbon atoms, A<NUM> and A<NUM> may be the hydrocarbon group having <NUM> to <NUM> carbon atoms of R described above, for example.

A<NUM> included in -COOA<NUM> represented as X or Y is a hydrogen atom or a hydrocarbon group having <NUM> to <NUM> carbon atoms and may be the hydrocarbon group having <NUM> to <NUM> carbon atoms of R described above, for example.

A<NUM> and A<NUM> included in -CONA<NUM>A<NUM> represented as X or Y each independently represent a hydrogen atom or a hydrocarbon group having <NUM> to <NUM> carbon atoms. In a case where A<NUM> and A<NUM> represent a hydrocarbon group having <NUM> to <NUM> carbon atoms, A<NUM> and A<NUM> may be the hydrocarbon group having <NUM> to <NUM> carbon atoms of R described above, for example.

It is preferable that X and Y are each independently a hydrogen atom, a halogen atom (fluorine atom, chlorine atom, bromine atom, or iodine atom), a nitro group, a methyl group, an ethyl group, an n-propyl group, a methoxy group, an ethoxy group, a propoxy group, a dimethylamino group, a diethylamino group, a methylethylamino group, a methylsulfanyl group, an ethylsulfanyl group, a methoxycarbonyl group, an ethoxycarbonyl group, or a trifluoromethyl group, and it is more preferable that X and Y are each independently a hydrogen atom, a halogen atom (fluorine atom, chlorine atom, bromine atom, or iodine atom), a nitro group, a methyl group, an n-propyl group, a methoxy group, a dimethylamino group, a methylsulfanyl group, a methoxycarbonyl group, or a trifluoromethyl group. In addition, it is further preferable that the substituent bonded to the <NUM>-position of the pyrimidine ring is <NUM>-pyridyl group, <NUM>-pyridyl group, <NUM>-pyridyl group, <NUM>,<NUM>-dichloro-<NUM>-pyridyl group, <NUM>-nitro-<NUM>-pyridyl group, <NUM>-methyl-<NUM>-pyridyl group, <NUM>-fluoro-<NUM>-pyridyl group, <NUM>-bromo-<NUM>-pyridyl group, <NUM>-methoxy-<NUM>-pyridyl group, <NUM>-dimethylamino-<NUM>-pyridyl group, <NUM>-methylsulfanyl-<NUM>-pyridyl group, <NUM>-methoxycarbonyl-<NUM>-pyridyl group, <NUM>-pyrazyl group, <NUM>-pyrimidyl group, <NUM>-trifluoromethyl-<NUM>-pyridyl group, <NUM>-n-propyl-<NUM>-pyridyl group, <NUM>-pyridazinyl group, <NUM>-pyrimidyl group, <NUM>-pyridazinyl group, <NUM>-pyrimidyl group, <NUM>-chloro-<NUM>-pyridazinyl group, <NUM>-chloro-<NUM>-pyrazyl group, <NUM>-fluoro-<NUM>-pyrimidyl group, <NUM>-bromo-<NUM>-pyrimidyl group, <NUM>-methyl-<NUM>-pyrimidyl group, <NUM>-methyl-<NUM>-pyridazinyl group, <NUM>-trifluoromethyl-<NUM>-pyrimidyl group, <NUM>-methylsulfanyl-<NUM>-pyrimidyl group, <NUM>-dimethylamino-<NUM>-pyrimidyl group, or <NUM>-methoxy-<NUM>-pyrimidyl group.

It is further preferable that the fluorine-containing pyrimidine compound is <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>,<NUM>-dichloro-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-nitro-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methyl-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-fluoro-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-bromo-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methoxy-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-dimethylamino-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methylsulfanyl-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methoxycarbonyl-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyrazyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-trifluoromethyl-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-n-propyl-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridazinyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridazinyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-chloro-<NUM>-pyridazinyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-chloro-<NUM>-pyrazyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-fluoro-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-bromo-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methyl-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methyl-<NUM>-pyridazinyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-trifluoromethyl-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methylsulfanyl-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine, <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-dimethylamino-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine, or <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methoxy-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine.

By virtue of having a specific substituent (pyridyl group, pyridazyl group, pyrazyl group, or pyrimidyl group) on the <NUM>-position of its pyrimidine ring and having specific substituents (-OR, -CF<NUM>, and -F) on the <NUM>-position, <NUM>-position, and <NUM>-position of its pyrimidine ring, the fluorine-containing pyrimidine compound of one embodiment can have an excellent effect in terms of structural expandability. Especially, a desired biological activity (for example, an inhibiting activity of a hormone or an enzyme, disinfecting activity, insecticidal activity, or herbicide activity) can be expected. The pyridine ring structure or diazine ring structure positioned on the <NUM>-position of the pyrimidine ring may further have a substituent or may have no substituent. When the pyridine ring structure or diazine ring structure has a substituent, an additional property can be imparted to the fluorine-containing pyrimidine compound of one embodiment thereby. In addition, since the substituent on the <NUM>-position and the substituent on the <NUM>-position of the pyrimidine ring are different groups (-OR and -F) from each other, derivatization to an asymmetric structure can be easily proceeded, and use as an intermediate is also expected. More specifically, -OR can be modified by reacting the fluorine-containing pyrimidine compound under an acidic condition to obtain a derivative. In addition, -F can be modified by reacting the fluorine-containing pyrimidine compound under a basic condition to obtain a derivative. A fluorine-containing pyrimidine compound of one embodiment is useful in a field of electronic material such as organic semiconductors and liquid crystals, for example.

A method for manufacturing a fluorine-containing pyrimidine compound according to one embodiment has:.

It is preferable that R in the general formulae (<NUM>) to (<NUM>) above represents an alkyl group having <NUM> to <NUM> carbon atoms.

The reaction between the fluoroisobutylene derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (a) above is represented by reaction formula (A) below.

The reaction between the fluoroisobutylene derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (b) above is represented by reaction formula (B) below. <CHM>
<CHM>.

The reaction between the fluoroisobutylene derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (c) above is represented by reaction formula (C) below.

The reaction between the fluoroisobutylene derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (d) above is represented by reaction formula (D) below.

The reaction between the fluoroisobutylene derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (e) above is represented by reaction formula (E) below.

The reaction between the fluoroisobutylene derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (f) above is represented by reaction formula (F) below.

In reaction formulae (A) to (F) above, the compounds of general formulae (<NUM>) to (<NUM>) each may be a form of a salt. When the compound is in a form of a salt, a form in which at least one moiety of the amino moiety (-NH<NUM>) and the imino moiety (=NH) forming the amidino group of each of the compounds of general formulae (<NUM>) to (<NUM>) is cationized to be (-NH<NUM>+) and (=NH<NUM>+) to form a salt with a counter ion is exemplified. The counter ion is not particularly limited as long as it is a monovalent anion, and examples thereof can include halide ions such as F-, Cl-, Br-, and I-.

In the method for manufacturing a fluorine-containing pyrimidine compound according to one embodiment, the reactions of (a) to (f) above can be conducted in one step in the presence of a hydrogen halide-trapping agent, for example. Therefore, the fluorine-containing pyrimidine compounds of general formulae (<NUM>) to (<NUM>) above can be simply obtained. Incidentally, in the reactions of (a) to (f) above, a cyclic pyrimidine structure is formed between the fluoroisobutylene derivative and the amidino group of each of the compounds of general formulae (<NUM>) to (<NUM>). A group derived from the pyridine ring structure or diazine ring structure of each of the compounds of general formulae (<NUM>) to (<NUM>) is positioned at the <NUM>-position of said pyrimidine structure. In addition, -OR, CF<NUM>, and F derived from the fluoroisobutylene derivative are respectively positioned at the <NUM>-position, <NUM>-position, and <NUM>-position of said pyrimidine structure.

The hydrogen halide-trapping agent is a substance having a function of trapping hydrogen fluoride (HF) formed from hydrogen atoms derived from the amidino group in each of the compounds of general formulae (<NUM>) to (<NUM>) and fluorine atoms derived from the fluoroisobutylene derivative of (<NUM>) in reaction formulae (A) to (F) above. As the hydrogen halide-trapping agent, sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium carbonate, potassium carbonate, sodium fluoride, potassium fluoride, and an organic nitrogen derivative such as pyridine, triethylamine, diisopropylethylamine, diazabicyclononene, diazabicycloundecene, methyltriazabicyclodecene, and diazabicyclooctane can be used.

A reaction temperature during the reactions of (a) to (f) above is preferably <NUM> to <NUM>, more preferably <NUM> to <NUM>, and still more preferably <NUM> to <NUM>. A reaction time for the reactions of (a) to (f) above is preferably <NUM> to <NUM> hours, more preferably <NUM> to <NUM> hours, and still more preferably <NUM> to <NUM> hours.

As a solvent used for the reactions of (a) to (f) above, an aprotic polar solvent such as tetrahydrofuran, monoglyme, diglyme, triglyme, tetraglyme, acetonitrile, dimethylformamide, dimethylacetamide, methylpyrrolidone, dimethylethyleneurea, tetramethylurea, dimethylsulfoxide, and sulfolan, or a two-phase system solvent of a protic polar solvent such as water and a water-insoluble solvent such as dichloromethane, toluene, and diethylether can be exemplified. In addition, as a catalyst for the reactions of (a) to (f) above, a quaternary ammonium halide such as benzyltriethylammonium chloride, a quaternary phosphonium halide, crown ethers, and the like can be used.

A method for manufacturing a fluorine-containing pyrimidine compound according to another embodiment has:.

Specifically, A<NUM> and A<NUM> of the compounds of general formulae (<NUM>) to (<NUM>) and (<NUM>) to (<NUM>) in steps (g) to (l) above can be similar to A<NUM> and A<NUM> of the compounds of general formulae (<NUM>) to (<NUM>) in steps (a) to (f) above.

It is preferable that R of general formulae (<NUM>) to (<NUM>) and (<NUM>) above represents an alkyl group having <NUM> to <NUM> carbon atoms.

The reaction between the fluoroisobutane derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (g) above is represented by reaction formula (G) below.

The reaction between the fluoroisobutane derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (h) above is represented by reaction formula (H) below.

The reaction between the fluoroisobutane derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (i) above is represented by reaction formula (I) below.

The reaction between the fluoroisobutane derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (j) above is represented by reaction formula (J) below.

The reaction between the fluoroisobutane derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (k) above is represented by reaction formula (K) below.

The reaction between the fluoroisobutane derivative represented by general formula (<NUM>) and the compound represented by general formula (<NUM>) in (l) above is represented by reaction formula (L) below.

In reaction formulae (G) to (L) above, compounds of general formulae (<NUM>) to (<NUM>) each may be a form of a salt. When the compounds are in a form of a salt, a form in which at least one moiety of the amino moiety (-NH<NUM>) and the imino moiety (=NH) forming the amidino group of each of the compounds of general formulae (<NUM>) to (<NUM>) is cationized to be (-NH<NUM>+) and (=NH<NUM>+) to form a salt with a counter ion is exemplified. The counter ion is not particularly limited as long as it is a monovalent anion, and examples thereof include halide ions such as F-, Cl-, Br-, and I-.

In the method for manufacturing a fluorine-containing pyrimidine compound according to said another embodiment, the reactions of (G) to (L) above can be conducted in one step, for example. Therefore, the fluorine-containing pyrimidine compounds of general formulae (<NUM>) to (<NUM>) above can be simply obtained. Incidentally, in the reactions of (g) to (l) above, a cyclic pyrimidine structure is formed between the fluoroisobutane derivative and the amidino group of each of the compounds of general formulae (<NUM>) to (<NUM>). A group derived from the pyridine ring structure or diazine ring structure of each of the compounds of general formulae (<NUM>) to (<NUM>) is positioned at the <NUM>-position of said pyrimidine structure. In addition, -OR, CF<NUM>, and F derived from the fluoroisobutane derivative are respectively positioned at the <NUM>-position, <NUM>-position, and <NUM>-position of said pyrimidine structure.

A reaction temperature during the reactions of (g) to (l) above is preferably <NUM> to <NUM>, more preferably <NUM> to <NUM>, and still more preferably <NUM> to <NUM>. A reaction time for the reactions of (g) to (l) above is preferably <NUM> to <NUM> hours, more preferably <NUM> to <NUM> hours, and still more preferably <NUM> to <NUM> hours. Hydrogen halide-trapping agents similar to those used in (a) to (f) above can be used in the reactions of (g) to (l) above.

As a solvent used for the reactions of (g) to (l) above, an aprotic polar solvent such as tetrahydrofuran, monoglyme, diglyme, triglyme, tetraglyme, acetonitrile, dimethylformamide, dimethylacetamide, methylpyrrolidone, dimethylethyleneurea, tetramethylurea, dimethylsulfoxide, and sulfolan, or a two-phase system solvent of a protic polar solvent such as water and a water-insoluble solvent such as dichloromethane, toluene, and diethylether can be exemplified. In addition, as a catalyst for the reactions of (g) to (l) above, a quaternary ammonium halide such as benzyltriethylammonium chloride, a quaternary phosphonium halide, crown ethers, and the like can be used.

Hereinabove, embodiments of the present invention have been described. However, the present invention is not limited to the above embodiments and includes various aspects encompassed by the concept and the scope of claims of the present invention, and various modifications can be made within the scope of the present invention.

Hereinafter, examples will be described in order to further clarify the effects of the present invention. However, the present invention is not limited to these examples.

To <NUM> of diethyl ether and <NUM> of water were added <NUM> (<NUM> mol) of <NUM>-amidinopyridine hydrochloride and <NUM> (<NUM> mol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene under cooling with iced water. Subsequently, <NUM> (<NUM> mol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was dropped to the resultant mixture so that the internal temperature thereof did not exceed <NUM>, and the resultant mixture was heated to room temperature. The resultant mixture was stirred for about <NUM> hours and subjected to extraction with hexane. The hexane phase was concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

Analysis results of the obtained objective substance were as follows.

To <NUM> of acetonitrile were added <NUM> (<NUM> mol) of <NUM>-amidinopyridine hydrochloride and <NUM> (<NUM> mol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene under cooling with iced water. Subsequently, a mixed solution including <NUM> (<NUM> mol) of triethylamine (hydrogen halide-trapping agent) and <NUM> of acetonitrile was dropped to the resultant mixture so that the internal temperature thereof did not exceed <NUM>, and the resultant mixture was heated to room temperature. The resultant mixture was stirred for about <NUM> hours and subjected to extraction with hexane. The hexane phase was concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

Manufacturing of <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine using <NUM>,<NUM>,<NUM>,<NUM>,<NUM>-pentafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-propane instead of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene of Example <NUM>.

To <NUM> of dichloromethane and <NUM> of water were added <NUM> (<NUM> mol) of <NUM>-amidinopyridinium hydrochloride and <NUM> (<NUM> mol) of <NUM>,<NUM>,<NUM>,<NUM>,<NUM>-pentafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-propane under cooling with iced water to obtain a solution. Subsequently, <NUM> (<NUM> mol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was dropped to the solution so that the internal temperature thereof did not exceed <NUM>. The solution was heated to room temperature after the dropping of the sodium hydroxide aqueous solution was completed. The solution was stirred for <NUM> hours and subsequently allowed to stand still, and the lower phase was slowly poured into <NUM> of HCl 1N aqueous solution. The lower phase thus obtained was dried with anhydrous sodium sulfate and filtered, and the obtained product was analyzed by GC-MS. As a result, a spectrum having a peak at the position corresponding to the molecular weight of <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine was observed.

Analysis results of the obtained product were similar to those of the product in Example <NUM>.

To <NUM> of dichloromethane and <NUM> of water were added <NUM> (<NUM> mol) of <NUM>-amidinopyridinium hydrochloride and <NUM> (<NUM> mol) of <NUM>,<NUM>,<NUM>,<NUM>,<NUM>-pentafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-propane under cooling with iced water to obtain a solution. Subsequently, <NUM> (<NUM> mol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was dropped to the solution so that the internal emperature thereof did not exceed <NUM>. The solution was heated to room temperature after the dropping of the sodium hydroxide aqueous solution was completed. The solution was stirred for <NUM> hours and subsequently allowed to stand still, and the lower phase of the solution was slowly poured into <NUM> of HCl 1N aqueous solution. The lower phase thus obtained was dried with anhydrous sodium sulfate and filtered, and the obtained product was analyzed by GC-MS. As a result, a spectrum having a peak at the position corresponding to the molecular weight of <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine was observed.

To <NUM> of dichloromethane and <NUM> of water were added <NUM> (<NUM> mol) of <NUM>-amidinopyridinium hydrochloride and <NUM> (<NUM> mol) of <NUM>,<NUM>,<NUM>,<NUM>,<NUM>-pentafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-propane under cooling with iced water to obtain a solution. Subsequently, <NUM> (<NUM> mol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was dropped to the solution so that the internal temperature thereof did not exceed <NUM>. The solution was heated to room temperature after the dropping of the sodium hydroxide aqueous solution was completed. The solution was stirred for <NUM> hours and subsequently allowed to stand still, and the lower phase of the solution was slowly poured into <NUM> of HCl 1N aqueous solution. The lower phase thus obtained was dried with anhydrous sodium sulfate and filtered, and the obtained product was analyzed by GC-MS. As a result, a spectrum having a peak at the position corresponding to the molecular weight of <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine was observed.

To <NUM> of diethyl ether and <NUM> of water were added <NUM> (<NUM> mmol) of <NUM>,<NUM>-chloropyridine-<NUM>-carboximidamide hydrochloride and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution was added to the resultant mixture, and the resultant mixture was stirred for <NUM> hours. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was added to the resultant mixture, and the resultant mixture was stirred at room temperature for <NUM> hours. After adding hexane and water, the resultant mixture was subjected to extraction with diethyl ether, and the organic phase was dried with sodium sulfate. The dried organic phase was subsequently concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance with a yield of <NUM>%. Analysis results of the obtained objective substance are as follows. <NUM>H NMR (<NUM>, CDCl<NUM>) δ ppm: <NUM> (s, <NUM>), <NUM> (s, <NUM>). APCIMS m/z = <NUM>.

To <NUM> of diethyl ether and <NUM> of water were added <NUM> (<NUM> mmol) of <NUM>-nitropicolinimidamide hydrochloride and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was added to the resultant mixture, and the resultant mixture was stirred for <NUM> hours. After adding water, the resultant mixture was subjected to extraction with diethyl ether, and the organic phase was dried with sodium sulfate. The dried organic phase was subsequently concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance with a yield of <NUM>%. Analysis results of the obtained objective substance are as follows. <NUM>H NMR (<NUM>, CDCl<NUM>) δ ppm: <NUM> (d, J = <NUM>, <NUM>), <NUM> (d, J = <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (s, <NUM>). APCIMS m/z = <NUM>.

To <NUM> of diethyl ether and <NUM> of water were added <NUM> (<NUM> mmol) of <NUM>-methylpyridine-<NUM>-carboximidamide hydrochloride and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was added to the resultant mixture, and the resultant mixture was stirred for <NUM> hours. After adding water, the resultant mixture was subjected to extraction with diethyl ether, and the organic phase was dried with sodium sulfate. The dried organic phase was subsequently concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance with a yield of <NUM>%. Analysis results of the obtained objective substance are as follows. <NUM>H NMR (<NUM>, CDCl<NUM>) δ ppm: <NUM> (d, J = <NUM>, <NUM>), <NUM> (d, J = <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>). APCIMS m/z = <NUM>.

To <NUM> of diethyl ether and <NUM> of water were added <NUM> (<NUM> mmol) of <NUM>-fluoropicolinimidamide hydrochloride and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was added to the resultant mixture, and the resultant mixture was stirred for one day. After adding water, the resultant mixture was subjected to extraction with diethyl ether, and the organic phase was dried with sodium sulfate. The dried organic phase was subsequently concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance with a yield of <NUM>%. Analysis results of the obtained objective substance are as follows. <NUM>H NMR (<NUM>, CDCl<NUM>) δ ppm: <NUM> (m, <NUM>), <NUM> (m, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (s, <NUM>). APCIMS m/z = <NUM>.

To <NUM> of diethyl ether and <NUM> of water were added <NUM> (<NUM> mmol) of <NUM>-bromonicotinimidamide hydrochloride and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was added to the resultant mixture, and the resultant mixture was stirred for <NUM> hours. After adding water, the resultant mixture was subjected to extraction with diethyl ether, and the organic phase was dried with sodium sulfate. The dried organic phase was subsequently concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance with a yield of <NUM>%. Analysis results of the obtained objective substance are as follows. <NUM>H NMR (<NUM>, CDCl<NUM>) δ ppm: <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (s, <NUM>). APCIMS m/z = <NUM>.

To <NUM> of diethyl ether and <NUM> of water were added <NUM> (<NUM> mmol) of <NUM>-methoxynicotinimidamide hydrochloride and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was added to the resultant mixture, and the resultant mixture was stirred for <NUM> hours. After adding water, the resultant mixture was subjected to extraction with diethyl ether, and the organic phase was dried with sodium sulfate. The dried organic phase was subsequently concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance with a yield of <NUM>%. Analysis results of the obtained objective substance are as follows. <NUM>H NMR (<NUM>, CDCl<NUM>) δ ppm: <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>). APCIMS m/z = <NUM>.

To <NUM> of diethyl ether and <NUM> of water were added <NUM> (<NUM> mmol) of <NUM>-(dimethylamino)pyridine-<NUM>-carboximidamide hydrochloride and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was added to the resultant mixture, and the resultant mixture was stirred for <NUM> hours. After adding water, the resultant mixture was subjected to extraction with diethyl ether, and the organic phase was dried with sodium sulfate. The dried organic phase was subsequently concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance with a yield of <NUM>%. Analysis results of the obtained objective substance are as follows. <NUM>H NMR (<NUM>, CDCl<NUM>) δ ppm: <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>). APCIMS m/z = <NUM>.

To <NUM> of diethyl ether and <NUM> of water were added <NUM> (<NUM> mmol) of <NUM>-(methylsulfanyl)pyridine-<NUM>-carboximidamide hydrochloride and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was added to the resultant mixture, and the resultant mixture was stirred for <NUM> hours. After adding water, the resultant mixture was subjected to extraction with diethyl ether, and the organic phase was dried with sodium sulfate. The dried organic phase was subsequently concentrated and subjected to column purification to provide <NUM> of an intermediate. To the intermediate were added <NUM> of diethyl ether, <NUM> of water, and two drops of sodium hydroxide 5N aqueous solution, and the resultant mixture was stirred for <NUM> hours at room temperature. After adding water, the resultant mixture was subjected to extraction with diethyl ether, and the organic phase was dried with sodium sulfate. The dried organic phase was subsequently concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance with a yield of <NUM>%. Analysis results of the obtained objective substance are as follows. <NUM>H NMR (<NUM>, CDCl<NUM>) δ ppm: <NUM> (d, J = <NUM>, <NUM>), <NUM> (d, J = <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>). APCIMS m/z = <NUM>.

To <NUM> (<NUM> mmol) of <NUM>-(methoxycarbonyl)pyridine-<NUM>-carboximidamide hydrochloride were added <NUM> of water, <NUM> (<NUM> mmol) of triethylamine (hydrogen halide-trapping agent), and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene dissolved in <NUM> of acetonitrile, and the resultant mixture was stirred for <NUM> hours at room temperature. The reaction liquid was subjected to vacuum concentration and column purification to provide <NUM> (<NUM> mmol) of the objective substance with a yield of <NUM>%. Analysis results of the obtained objective substance are as follows. <NUM>H NMR (<NUM>, CDCl<NUM>) δ ppm: <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (dd, J = <NUM>, <NUM>, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>). APCIMS m/z = <NUM>.

To <NUM> of dichloromethane and <NUM> of water were added <NUM> (<NUM> mol) of <NUM>-amidinopyrazine hydrochloride and <NUM> (<NUM> mol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene under cooling with iced water to obtain a solution. Subsequently, <NUM> (<NUM> mol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was dropped to the solution so that the internal temperature thereof did not exceed <NUM>, and the solution was heated to room temperature. After a lapse of about <NUM> hours, the dichloromethane phase was collected, and dichloromethane was distilled away under reduced pressure. The precipitate was dissolved in hexane followed by column purification to provide <NUM> of the objective substance with an isolated yield of <NUM>%. Analysis results of the obtained objective substance are as follows.

To <NUM> of dichloromethane and <NUM> of water were added <NUM> (<NUM> mmol) of <NUM>-amidinopyrimidine hydrochloride and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene under cooling with iced water to obtain a solution. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was dropped to the solution so that the internal temperature thereof did not exceed <NUM>, and the solution was heated to room temperature. After a lapse of about <NUM> hours, the dichloromethane phase was collected, and dichloromethane was distilled away under reduced pressure. The precipitate was dissolved in hexane followed by column purification to provide <NUM> of the objective substance with an isolated yield of <NUM>%. Analysis results of the obtained objective substance are as follows.

To <NUM> of diethyl ether and <NUM> of water were added <NUM> (<NUM> mmol) of <NUM>-(trifluoromethyl)pyridine-<NUM>-carboximidamide hydrochloride and <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene to obtain solution <NUM>. Subsequently, <NUM> (<NUM> mmol) of sodium hydroxide 5N aqueous solution (hydrogen halide-trapping agent) was added to solution <NUM>, and solution <NUM> was stirred for one day. Then, after adding water, solution <NUM> was subjected to extraction with diethyl ether, and the organic phase was dried with sodium sulfate. The organic phase was subsequently concentrated and subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-trifluoromethyl-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-(trifluoromethyl)pyridine-<NUM>-carboximidamide hydrochloride is shown below.

Analysis results of the obtained objective substance are as follows.

After dissolving <NUM> (<NUM> mmol) of <NUM>-n-propyl-<NUM>-picolinamidine hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for <NUM> hours at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-n-propyl-<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-n-propyl-<NUM>-picolinamidine hydrochloride is shown below.

After dissolving <NUM> (<NUM> mmol) of pyridazine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for <NUM> hours at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridazinyl)-<NUM>-trifluoromethylpyrimidine by reacting pyridazine-<NUM>-carboximidamide hydrochloride is shown below. <CHM>
<CHM>.

After dissolving <NUM> (<NUM> mmol) of pyrimidine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for one day at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine by reacting pyrimidine-<NUM>-carboximidamide hydrochloride is shown below. <CHM>
<CHM>.

After dissolving <NUM> (<NUM> mmol) of pyrimidine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for <NUM> hours at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

After dissolving <NUM> (<NUM> mmol) of <NUM>-chloropyridazine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for <NUM> hours at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> of a crudely purified product of the objective substance.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-chloro-<NUM>-pyridazinyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-chloropyridazine-<NUM>-carboximidamide hydrochloride is shown below.

After dissolving <NUM> (<NUM> mmol) of <NUM>-chloropyrazine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for two days at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-chloro-<NUM>-pyrazyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-chloropyrazine-<NUM>-carboximidamide hydrochloride is shown below.

After dissolving <NUM> (<NUM> mmol) of <NUM>-fluoropyrimidine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for <NUM> hours at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> of a crudely purified product of the objective substance.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-fluoro-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-fluoropyrimidine-<NUM>-carboximidamide hydrochloride is shown below.

After dissolving <NUM> (<NUM> mmol) of <NUM>-bromopyrimidine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for <NUM> hours at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-bromo-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-bromopyrimidine-<NUM>-carboximidamide hydrochloride is shown below.

After dissolving <NUM> (<NUM> mmol) of <NUM>-methylpyrimidine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for <NUM> hours at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methyl-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-methylpyrimidine-<NUM>-carboximidamide hydrochloride is shown below.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methyl-<NUM>-pyridazinyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-methylpyrimidine-<NUM>-carboximidamide hydrochloride is shown below.

After dissolving <NUM> (<NUM> mmol) of <NUM>-(trifluoromethyl)pyrimidine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for <NUM> hours at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-trifluoromethyl-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-(trifluoromethyl)pyrimidine-<NUM>-carboximidamide hydrochloride is shown below.

After dissolving <NUM> (<NUM> mmol) of <NUM>-(methylsulfanyl)pyrimidine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for <NUM> hours at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance. A yield of the objective substance was <NUM>%.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methylsulfanyl-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-(methylsulfanyl)pyrimidine-<NUM>-carboximidamide hydrochloride is shown below.

After dissolving <NUM> of crudely purified <NUM>-(dimethylamino)pyrimidine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for <NUM> hours at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> of a crudely purified product of the objective substance.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-dimethylamino-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-(dimethylamino)pyrimidine-<NUM>-carboximidamide hydrochloride is shown below. <CHM>
<CHM>.

After dissolving <NUM> (<NUM> mmol) of <NUM>-methoxypyrimidine-<NUM>-carboximidamide hydrochloride in <NUM> of acetonitrile, <NUM> (<NUM> mmol) of <NUM>,<NUM>,<NUM>,<NUM>-tetrafluoro-<NUM>-methoxy-<NUM>-trifluoromethyl-<NUM>-propene and <NUM> (<NUM> mmol) of N,N-diisopropylethylamine (hydrogen halide-trapping agent) were added thereto, and the resultant mixture was stirred for one day at room temperature to obtain a reaction liquid. Thereafter, the reaction liquid was subjected to column purification to provide <NUM> (<NUM> mmol) of the objective substance.

The reaction to obtain <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-methoxy-<NUM>-pyrimidyl)-<NUM>-trifluoromethylpyrimidine by reacting <NUM>-methoxypyrimidine-<NUM>-carboximidamide hydrochloride is shown below.

An acetone solution in which <NUM>-fluoro-<NUM>-methoxy-<NUM>-(<NUM>-pyridyl)-<NUM>-trifluoromethylpyrimidine prepared in Example <NUM> is diluted to a concentration of <NUM> ppm was prepared, and an oatmeal medium, which was separately prepared, was treated by dropping <NUM>µl of the acetone solution thereon and air dried. Thereafter, a rice blast disc having a size of <NUM> was placed so that bacterial flora contacted the treated surface of the oatmeal medium. Thereafter, the oatmeal medium was allowed to stand still in a thermostatic chamber at <NUM> for five days, and elongation lengths of fungal filaments were subsequently examined. A preventive value calculated according to the following formula was <NUM>.

Incidentally, the phrase "without treatment" in the above formula indicates that a medium was treated by dropping only acetone thereon as a test liquid.

Claim 1:
A fluorine-containing pyrimidine compound represented by a general formula (<NUM>), (<NUM>), (<NUM>), (<NUM>), (<NUM>), or (<NUM>) below:
<CHM>
wherein, in the general formulae (<NUM>) to (<NUM>) above,
R represents a hydrocarbon group having <NUM> to <NUM> carbon atoms, and
X and Y each independently represent a hydrogen atom, a halogen atom, a hydrocarbon group having <NUM> to <NUM> carbon atoms, -CnF2n+<NUM> (n is an integer of <NUM> to <NUM>), a nitro group, a boronate group, -OA<NUM>, -SOmA<NUM> (m is an integer of <NUM> to <NUM>), -NA<NUM>A<NUM>, -COOA<NUM>, or -CONA<NUM>A<NUM>, and A<NUM> and A<NUM> each independently represent a hydrogen atom or a hydrocarbon group having <NUM> to <NUM> carbon atoms.