Patent Description:
The dynamic growth of UV curing is dependent on continued innovation to support this technology in the overcoming of always new challenges and this is reflected by rapid development of new materials needed for the formulations. In particular, one key component is the photoinitiator (PI), its role is that to convert light to chemical energy in the form of reactive intermediates. These intermediates are radicals able to initiate radical polymerization of the double bonds present in the formulation to be cured. The development in the field of photoinitiators is stimulated by various factors. Firstly, there is a continuous improvement of photoinitiators for existing applications such as coatings, inks, adhesives or electronics because there is no single photoinitiator that is able to meet all the requirements of each application, like for instance line speed, surface curing, no discoloration after curing or solubility. Secondly, the introduction of new lamps, such as LED lamps, stimulated the development of photoinitiators tuned at that wavelength. Thirdly, the increasing number of photoinitiators banned as toxic or reprotoxic. <CIT>, for example, describes photocurable compositions including ketocoumarine compounds as photoinitiators.

So, the research of new photoinitiators is always required in order to mimic standard photoinitiators or to overcome problems such as yellowing, or to higher line speed, curing under LED lamps, deep curing.

In recent years, some new classes were explored, some examples are acylgermanium photoinitiators (<CIT>, <CIT>), benzoyl phenyltelluride PIs (<NPL>), silicon based PIs (<CIT>, <NPL>, <NPL>, <NPL>, <NPL>). Ketoquinolones are a class of compounds known in literature for their pharmacological properties. In recent years, many efforts were made on improving their synthesis, but no one tested the ability of these compounds as photoinitiators.

It is a first aim of the invention to provide for novel photocurable compositions comprising ketoquinolones.

It is a further aim of the invention to provide for novel ketoquinolones, their use as photoinitiators and photocurable compositions comprising them.

Is a further aim of the invention to provide for a process for photocuring ethylenically unsaturated compounds using ketoquinolones, as well as articles of manufacture made by said process.

We surprisingly discovered that a class of ketoquinolones is able to generate radicals under light irradiation. Moreover, under appropriate substitutions we were able to achieve the photopolymerization also under LED, that means that we were able to tune the absorption properties of this class of compounds without affecting the reactivity. The new compounds were tested in different formulations and compared to well know commercial photoinitiators demonstrating their good performance. So, we unexpectedly found that specific ketoquinolones well react to light sources in a range between <NUM> to <NUM>, preferably in a range between <NUM> to <NUM> , and more preferably, react to LED sources emitting in the range from <NUM> to <NUM>, representing a novelty compared to prior art. Therefore, the present invention relates to specific ketoquinolones useful as photoinitiators, compositions comprising said photoinitiators and a process for the photopolymerization of compositions comprising said ketoquinolones.

According to one of its aspects, the present invention relates to a photocurable composition comprising:.

According to the present invention, the terms "photocuring" and "photopolymerizing" and related terms, are synonyms.

The expression "based on the total weight of the composition" herein means that the % weight amounts of the compounds and of the additional components of the composition are calculated on the sum of the weights of said compounds and of said additional components, irrespective of the fact that water and/or solvents may be present in the composition.

According to another of its aspects, the present invention relates to a compound of formula (Ia):
<CHM>
wherein:.

According to another of its aspects, the present invention relates to a process for photopolymerizing which comprises:.

In the present description the expressions "alkyl" or "alkyl group" mean, where not differently indicated, a linear or branched, saturated alkyl chain containing the given number of carbon atoms and includes all possibility for each number of carbon atoms in the alkyl group, i.e. for three carbon atoms: n-propyl and isopropyl; for four carbon atoms: n-butyl, isobutyl and tertiary-butyl; for five carbon atoms: n-pentyl, <NUM>,<NUM>-dimethyl-propyl, <NUM>,<NUM>-dimethylpropyl and <NUM>-methyl-butyl, etc..

"Alkenyl" or "alkenyl group" mean an unsaturated group containing from <NUM> to <NUM> carbon atoms, preferably C3 to C12 carbon atoms, which can be, for example, allyl, methallyl or undecenyl.

The expressions "cycloalkyl" or "cycloalkyl group" mean, where not differently indicated, an aliphatic ring containing <NUM> or <NUM> carbon atoms which can be cyclopentyl or cyclohexyl.

The expressions "aryl" or "aryl group" include, but it is not limited to, for example a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, an anthracenyl group, an indenyl group, a fluorenyl group.

The expressions "heteroaryl" or "heteroaryl group" include, but it is not limited to, for example a furan, a thiophene, a pyrrole, an oxazole, an isooxazole, a thiazole, an isothiazole, an imidazole, a pyrazole, a pyrane, a pyridine, a pyrrolidine, a piperidine, an indole, a quinoline, an isoquinoline, a xanthene, a carbazole, an acridine, an indeline, a julolidine and others.

The expression "C1-C50 alkyl which is interrupted by one or more oxygens" means that, in case more than one oxygen atom is present, said oxygen atoms are separated from one another by at least one methylene group, i.e. the oxygen atoms are non-consecutive. Preferably, oxygen atoms are separated by an ethylene or a n-propylene chain. Preferably <NUM> to <NUM> oxygen atoms are present, more preferably <NUM> to <NUM>. Examples include the following: -O-CH<NUM>-OCH<NUM>, -O-CH<NUM>CH<NUM>-OCH<NUM>CH<NUM>, -O-[CH<NUM>CH<NUM>O]vCH<NUM>, -O-[CH<NUM>CH<NUM>O]vOH, -O-[CH<NUM>CH<NUM>O]vCH<NUM>CH<NUM>, -CH<NUM>-O-[CH<NUM>CH<NUM>O]vCH<NUM> with v=<NUM>-<NUM>, -O-[CH<NUM>CH<NUM>CH<NUM>O]pOH, -O-[CH<NUM>CH<NUM>CH<NUM>O]pCH<NUM>, -O-[CH<NUM>CH<NUM>CH<NUM>O]pCH<NUM>CH<NUM>, -CH<NUM>-O-[CH<NUM>CH<NUM>CH<NUM>O]pCH<NUM> with p=<NUM>-<NUM>.

When a group is substituted, the term "substituted" means that said group bears one or more substituents, said substituents being preferably selected from halogen atom, alkyl, cycloalkyl, alkoxy, alkylamino, dialkylamino, alkylthio or arylthio group, heterocyclic groups; preferably selected from methyl, ethyl, isopropyl, tert-butyl, phenyl, trifluoromethyl, cyano, acetyl, ethoxycarbonyl, carboxyl, carboxylate, amino, methylamino, dimethylamino, ethylamino, diethylamino, isopropylamino, diisopropylamino, cyclohexylamino, dicyclohexylamino, acetylamino, piperidino, pyrrolidyl, methoxy, ethoxy, propoxy, isopropoxy, butoxy, pentyloxy, phenoxy, hydroxyl, acetoxy, -PO<NUM>H, methylthio, ethylthio, i-propylthio, n-propylthio, phenyltio, mercapto, acetylthio, thiocyano, methylsulfinyl, methylsulfonyl, dimethylsulfonyl, sulfonate groups, fluorine atom, chlorine atom, bromine atom, iodine atom, trimethylsilyl, triethylsilyl, trimethylstannyl, furyl, thienyl, pyridyl and morpholino. Among said substituents, electron donating groups such as alkoxy groups, for example methoxy, ethoxy, isopropoxy, tert-butoxy or phenoxy groups, methyl, ethyl, isopropyl, hydroxyl, acetoxy, benzoyloxy groups, etc. as well as a thioalkyl group, such as methylthio, ethylthio, n-propylthio, i-propylthio, butylthio, pentylthio, or a arylthio group, such as phenylthio, are preferred.

Unless expressly otherwise specified, herein all the % are weight percentage.

According to an embodiment, in formula (I) of the present description R<NUM>, R<NUM>, R<NUM> and R<NUM> are selected from substituted or unsubstituted C2-C20 alkyl. According to preferred embodiments, in formula (I) of the present description, at least one of the following conditions are preferred:.

According to a preferred embodiment, two, three or all the above conditions are simultaneously met.

In another preferred embodiment, in the compounds of formula (I), Qui is a quinolone group of formula (A), in which R<NUM> is hydrogen, at least two of R<NUM>, R<NUM>, R<NUM> and R<NUM> are -O-Rs group and R<NUM> is a C1-C20 alkyl group. According to preferred embodiments, in formula (Ia) of the present description, at least one of the following conditions are preferred:.

In another preferred embodiment, in the compounds of formula (Ia), Qui' is a quinolone group of formula (A'), in which R'<NUM> is hydrogen, at least two of R'<NUM>, R'<NUM>, R'<NUM> and R'<NUM> are -O-Rs group and R<NUM> is a C1-C20 alkyl group, preferably a C1-C10 alkyl group.

The compounds represented by formulas (I) or (Ia) can be prepared according conventional methods known to the skilled in the art as reported, for example, in <NPL>.

According to the invention, the photoinitiators of formulas (I) or (Ia) can be used to prepare photocurable compositions comprising ethylenically unsaturated compounds (a).

Said unsaturated compounds (a) can contain one or more olefinic double bonds. They can be low-molecular weight (monomeric) or high-molecular weight (oligomeric) compounds.

Examples of suitable low molecular weight monomers (monomeric compounds) having one double bond are alkyl or hydroxyalkyl acrylates or methacrylates, such as methyl-, ethyl-, butyl-, <NUM>-ethylhexyl-,<NUM>-hydroxyethyl- or isobornyl-acrylate; and methyl or ethyl methacrylate. Further examples are resins modified with silicon or fluorine, e.g. silicone acrylates. Further examples of these monomers are acrylonitrile, acrylamide, methacrylamide, N-substituted (meth)acrylamides, styrene, alkylstyrenes and halogeno styrenes, vinyl esters such as vinyl acetate, vinyl ethers such as iso-butyl vinyl ether, N-vinylpyrrolidone, vinyl chloride or vinylidene chloride.

Examples of monomers having more than one double bond are the ethylene glycol diacrylate, propylene glycol diacrylate, neopentyl glycol diacrylate, hexamethylene glycol diacrylate, bisphenol A diacrylate, <NUM>,<NUM>'-bis-(<NUM>-acryloyloxyethoxy)-diphenylpropane, trimethylolpropane triacrylate, pentaerythritol triacrylate or tetraacrylate, vinyl acrylate, divinyl benzene, divinyl succinate, diallyl phthalate, triallyl phosphate, triallyl isocyanurate or tris-(<NUM>-acryloylethyl) isocyanurate.

Examples of high-molecular weight (oligomeric) polyunsaturated compounds are acrylated epoxy resins, acrylated or vinyl-ether- or epoxy-group-containing polyesters, acrylated polyurethanes or acrylated polyethers. Further examples of unsaturated oligomers are unsaturated polyester resins which are usually prepared from maleic acid, phthalic acid and one or more diols and which have molecular weights of from about <NUM> Da to <NUM>,<NUM> Da. Such unsaturated oligomers can also be referred to as prepolymers.

Examples of compounds (a) which are particularly suitable for the implementation of the present invention, are esters of ethylenically unsaturated carboxylic acids and polyols or polyepoxides, and polymers containing ethylenically unsaturated groups in the chain or in side groups, e.g. unsaturated polyesters, polyamides and polyurethanes and copolymers thereof, alkyl resins, polybutadiene and butadiene copolymers, polyisoprene and isoprene copolymers, polymers and copolymers having (meth)acrylic groups in side chains, as well as mixtures thereof.

Illustrative examples of unsaturated carboxylic acids or anhydrides, useful for the preparation of the above esters, are acrylic acid, methacrylic acid, maleic anhydride, crotonic acid, itaconic acid, cinnamic acid and unsaturated fatty acids such as linolenic acid and oleic acid. Acrylic and methacrylic acid are preferred.

Examples of polyols, which can also be esterified, are aromatic and aliphatic and cycloaliphatic polyols, preferably aliphatic and cycloaliphatic polyols.

Aromatic polyols are, for example, hydroquinone, <NUM>,<NUM>'-dihydroxydiphenyl, <NUM>,<NUM>-di(<NUM>-hydroxyphenyl) propane, as well as novolaks and resoles. Polyepoxides, which can be esterified, include those based on the said polyols, especially the reaction products between aromatic polyols and epichlorohydrin. Also suitable as polyols are polymers and copolymers that contain hydroxyl groups in the polymer chain or in side groups, for example polyvinyl alcohol and copolymers thereof or polymethacrylic acid hydroxyalkyl esters or copolymers thereof. Further suitable polyols are oligoesters carrying hydroxyl terminal groups.

Examples of aliphatic and cycloaliphatic polyols include alkylenediols containing preferably from <NUM> to <NUM> carbon atoms, such as ethylene glycol, <NUM>,<NUM>- or <NUM>,<NUM>-propanediol, <NUM>,<NUM>-, <NUM>,<NUM>- or <NUM>,<NUM>-butanediol, pentanediol, hexanediol, octanediol, dodecanediol, diethylene glycol, triethylene glycol, polyethylene glycols having molecular weights of preferably from <NUM> Da to <NUM>,<NUM> Da, <NUM>,<NUM>-cyclopentanediol, <NUM>,<NUM>-, <NUM>,<NUM>- or <NUM>,<NUM>-cyclohexanediol, <NUM>,<NUM>-dihydroxymethyl cyclohexane, glycerol, tris(β-hydroxy-ethyl)amine, trimethylolethane, trimethylolpropane, pentaerythritol, dipentaerythritol and sorbitol.

Further suitable ethylenically unsaturated compounds (a) are unsaturated polyamides obtained from unsaturated carboxylic acids and aromatic, aliphatic and cycloaliphatic polyamines having preferably from <NUM> to <NUM>, preferably from <NUM> to <NUM>, amino groups. Examples of such polyamines are: ethylenediamine, <NUM>,<NUM>- or <NUM>,<NUM>-propylenediamine, <NUM>,<NUM>-, <NUM>,<NUM>- or <NUM>,<NUM>-butylenediamine, <NUM>,<NUM>-pentylenediamine, <NUM>,<NUM>-hexylenediamine, octylenediamine, dodecylene diamine, <NUM>,<NUM>-diaminocyclohexane, isophoronediamine, phenylene diamine, bisphenylenediamine, di-(β-aminoethyl) ether, diethylene triamine, triethylenetetramine and di(β-aminoethoxy)- and di(β-aminopropoxy)ethane. Other suitable polyamines are polymers and copolymers which may contain additional amino groups in the side chain and oligoamides containing amino end groups.

Specific examples of such unsaturated polyamides are: methylenebisacrylamide, <NUM>,<NUM>-hexamethylene bisacrylamide, diethylenetriamine trismethacrylamide, bis(methacrylamidopropoxy) ethane and N-[(β-hydroxyethoxy)ethyl]-acrylamide.

Unsaturated polyurethanes are also suitable for the implementation of the present invention as components (a), for example those derived from saturated or unsaturated diisocyanates and unsaturated or saturated diols.

Polybutadiene and polyisoprene and copolymers thereof may also be used. Suitable monomers include, for example, olefins, such as ethylene, propene, butene and hexene, (meth)acrylates, acrylonitrile, styrene and vinyl chloride.

Polymers having unsaturated (meth)acrylate groups in the side chain can also be used as component (a). They may typically be reaction products of epoxy resins based on novolak with (meth)acrylic acid; homo- or copolymers of vinyl alcohol or hydroxyalkyl derivatives thereof that have been esterified with (meth)acrylic acid; and homo- and co-polymers of (meth)acrylates that have been esterified with hydroxyalkyl (meth)acrylates.

The photocurable compositions of the present invention can also comprise one or more of the following components: (c) photosensitizers and/or (d) accelerators/coinitiators and/or further (e) photoinitiators and/or (f) additives, in addition to compounds (a) and (b).

The photocurable compositions of the present invention can also be formulated in compositions further comprising water and/or solvents, such as organic solvents.

Photosensitizers (c) can be present in an amount comprised between <NUM> and <NUM>% by weight, based on the total weight of the composition, preferably between <NUM> and <NUM>% by weight.

Examples of photosensitizers are those commonly used in the art, aromatic carbonyl compounds, e.g. benzophenones, thioxanthones, anthraquinones and <NUM>-acylcoumarin derivatives, terphenyls, styryl ketones, and <NUM>-(aroylmethylene)-thiazolines, camphorquinones and also eosin, rhodamine and erythrosine dyes.

Examples of thioxanthones are thioxanthone, <NUM>-isopropyl thioxanthone, <NUM>-chloro thioxanthone, <NUM>-dodecyl thioxanthone, <NUM>,<NUM>-diethyl thioxanthone, <NUM>,<NUM>-dimethyl thioxanthone, <NUM>-methoxycarbonyl thioxanthone, <NUM>-ethoxycarbonyl thioxanthone, <NUM>-(<NUM>-methoxyethoxycarbonyl) thioxanthone, <NUM>-butoxycarbonyl thioxanthone, <NUM>-butoxycarbonyl-<NUM>-methyl thioxanthone, <NUM>-cyano-<NUM>-chloro thioxanthone, <NUM>-ethoxycarbonyl-<NUM>-chloro thioxanthone, <NUM>-ethoxycarbonyl-<NUM>-ethoxy thioxanthone, <NUM>-ethoxycarbonyl-<NUM>-amino thioxanthone, <NUM>-ethoxycarbonyl-<NUM>-phenylsulfuryl thioxanthone, <NUM>,<NUM>-di[<NUM>-(<NUM>-methoxyethoxy)ethoxycarbonyl] thioxanthone, <NUM>-ethoxycarbonyl-<NUM>-(<NUM>-methyl-<NUM>-morpholinoethyl) thioxanthone, <NUM>-methyl-<NUM>-dimethoxymethyl thioxanthone, <NUM>-methyl-<NUM>-(<NUM>,<NUM>-dimethoxybenzyl) thioxanthone, <NUM>-morpholinomethyl thioxanthone, <NUM>-methyl-<NUM>-morpholinomethyl thioxanthone, N-allylthioxanthone-<NUM>,<NUM>-dicarboximide, N-octylthioxanthone-<NUM>,<NUM>-dicarboximide, N-(<NUM>,<NUM>,<NUM>,<NUM>-tetramethylbutyl)-thioxanthone-<NUM>,<NUM>-dicarboximide, <NUM>-phenoxy thioxanthone, <NUM>-ethoxycarbonyl-<NUM>-<NUM>-methoxythioxanthone, <NUM>-ethoxycarbonyl-<NUM>-methylthioxanthone, thioxanthone-<NUM>-polyethylene glycol ester, <NUM>-hydroxy-<NUM>-(<NUM>,<NUM>-dimethyl-<NUM>-oxo-<NUM>-thioxanthon-<NUM>-yloxy)-N,N,N-trimethyl-<NUM>-propanaminium chloride, or those described in the patent application <CIT>, such as n-dodecyl-<NUM>-methyl-thioxanthone-<NUM>-carboxylate and N,N-disobutyl-<NUM>-methyl-thioxanthone-<NUM>-carbamide. Also suitable are polymeric thioxanthone derivatives (e.g. Omnipol® TX from IGM Resins B. , Genopol® TX-<NUM> from Rahn A. , Speedcure® <NUM> from Lambson Limited).

Example of benzophenones are benzophenone, <NUM>-phenyl benzophenone, <NUM>-methoxy benzophenone, <NUM>,<NUM>'-dimethoxybenzophenone, <NUM>,<NUM>'-dimethyl benzophenone, <NUM>,<NUM>'-dichloro benzophenone, <NUM>,<NUM>'-dimethylamino benzophenone, <NUM>,<NUM>'-diethylamino benzophenone, <NUM>-methyl benzophenone, <NUM>,<NUM>,<NUM>-trimethyl benzophenone, <NUM>-(<NUM>-methylthiophenyl) benzophenone, <NUM>,<NUM>'-dimethyl-<NUM>-methoxy benzophenone, methyl <NUM>-benzoyl benzoate, <NUM>-(<NUM>-hydroxyethylthio) benzophenone, <NUM>-(<NUM>-tolylthio) benzophenone, <NUM>-benzoyl-N,N,N-trimethylbenzene methanaminium chloride, <NUM>-hydroxy-<NUM>-(<NUM>-benzoylphenoxy)-N,N,N-trimethyl-<NUM>-propanaminium chloride monohydrate, <NUM>-(<NUM>-acryloyl-<NUM>,<NUM>,<NUM>,<NUM>,<NUM>-pentaoxatridecyl) benzophenone, <NUM>-benzoyl-N,N-dimethyl-N-[<NUM>-(<NUM>-oxo-<NUM>-propenyl)oxylethyl-benzene methanaminium chloride. Also suitable are polymeric benzophenone derivatives (e.g. Omnipol® BP, Omnipol® <NUM> and Omnipol® <NUM> all from IGM Resins B. , Genopol® BP-<NUM> from Rahn A. and Speedcure® <NUM> from Lambson Limited).

Examples of <NUM>-acylcoumarin derivatives are <NUM>-benzoyl coumarin, <NUM>-benzoyl-<NUM>-methoxy coumarin, <NUM>-benzoyl-<NUM>,<NUM>-di(propoxy) coumarin, <NUM>-benzoyl-<NUM>,<NUM>-dichloro coumarin, <NUM>-benzoyl-<NUM>-chloro coumarin, <NUM>,<NUM>'-carbonyl-bis[<NUM>,<NUM>-di(propoxy) coumarin], <NUM>,<NUM>'-carbonyl-bis(<NUM>-methoxy coumarin), <NUM>,<NUM>'-carbonyl-bis(<NUM>-diethylamino coumarin), <NUM>-isobutyroyl coumarin, <NUM>-benzoyl-<NUM>,<NUM>-dimethoxy coumarin, <NUM>-benzoyl-<NUM>,<NUM>-diethoxy coumarin, <NUM>-benzoyl-<NUM>,<NUM>-dibutoxy coumarin, <NUM>-benzoyl-<NUM>,<NUM>-di(methoxyethoxy) coumarin, <NUM>-benzoyl-<NUM>,<NUM>-di(allyloxy) coumarin, <NUM>-benzoyl-<NUM>-dimethylamino coumarin, <NUM>-benzoyl-<NUM>-diethylamino coumarin, <NUM>-isobutyroyl-<NUM>,<NUM>-dimethylamino coumarin, <NUM>,<NUM>-dimethoxy-<NUM>-(<NUM>-naphthoyl) coumarin, <NUM>,<NUM>-dimethoxy-<NUM>(<NUM>-naphthoyl)-coumarin, <NUM>-benzoylbenzo [f]coumarin, <NUM>-diethylamino-<NUM>-thienoyl coumarin, <NUM>-(<NUM>-cyanobenzoyl)-<NUM>,<NUM>-dimethoxy coumarin, or those described in <CIT> and <CIT>.

Examples of <NUM>-(aroylmethylene) thiazolines are <NUM>-methy-<NUM>,<NUM>-benzoylmethylene-β-naphtho thiazoline, <NUM>-methyl-<NUM>-benzoylmethylene-benzo thiazoline, <NUM>-ethyl-<NUM>-propionylmethylene-β-naphtho thiazoline. Examples of other aromatic carbonyl compounds are acetophenone, <NUM>-methoxyacetophenone, <NUM>-phenylacetophenone, benzyl, such as that described in <CIT>, <NUM>-acetylnaphthalene, <NUM>-naphthaldehyde, <NUM>,<NUM>-anthraquinone, <NUM>-fluorenone, dibenzosuberone, xanthone, <NUM>,<NUM>-bis(<NUM>-diethylaminobenzylidene) cyclopentanone, α-(para-dimethylamino benzylidene), ketones, such as <NUM>-(<NUM>-dimethylamino-benzylidene)-indan-<NUM>-one or <NUM>-(<NUM>-dimethylaminophenyl)-<NUM>-indan-<NUM>-yl-propenone, <NUM>-phenylthiophthalimide, N-methyl-<NUM>,<NUM>-di(ethylthio)phthalimide.

Particularly preferred are thioxanthones and <NUM>-acylcoumarins.

It was observed that the above components (c) increase the activity of photoinitiators (b) without shortening the shelf life of the compositions. Moreover, such compositions have the special advantage that an appropriate choice of the photosensitizer (c) allows the spectral sensitivity of photoinitiator (b) to be shifted to any desired wavelength region. The skilled in the art is able to select the suitable photosensitizer (c) to make the photoinitiator(s) (b) work at any desired wavelength region.

The accelerators/coinitiators (d), can be present in an amount comprised between <NUM> and <NUM>% by weight, of the total weight of the composition, preferably from <NUM> to <NUM>% by weight.

Examples of suitable accelerators/coinitiators are alcohols, thiols, thioethers, amines or ethers that have an available hydrogen, bonded to a carbon adjacent to the heteroatom, disulfides and phosphines, e.g. as described in <CIT> and <CIT>.

Suitable examples of amine accelerators/co-initiators include, but are not limited to, aliphatic, cycloaliphatic, aromatic, aryl-aliphatic, heterocyclic, oligomeric or polymeric amines. They can be primary, secondary or tertiary amines, for example butyl amine, dibutyl amine, tributyl amine, cyclohexyl amine, benzyldimethyl amine, di-cyclohexyl amine, N-phenyl glycine, triethyl amine, phenyl-diethanol amine, triethanolamine, piperidine, piperazine, morpholine, pyridine, quinoline, esters of dimethylamino benzoic acid, Michler's ketone (<NUM>,<NUM>'-bis-dimethyl aminobenzophenone) and derivatives thereof.

As the amine accelerators/co-initiators, an amine-modified acrylate compound can be used; examples of such amine-modified acrylate include acrylates modified by reaction with a primary or secondary amine that are described in <CIT>, <CIT>, <CIT> or <CIT>. Multifunctional amine and polymeric amine derivatives are also suitable as co-initiators some examples are Omnipol® ASA from IGM Resins B. , Genopol® AB-<NUM> from Rahn A. , Speedcure® <NUM> from Lambson Limited or those described in <CIT>.

The further photoinitiators (e) can be present in an amount comprised between <NUM> and <NUM> % by weight, of the total weight of the composition, preferably between <NUM> and <NUM>% by weight of the composition.

Examples of other suitable photoinitiators (e) are camphorquinone, benzophenone, benzophenone derivatives, acetophenone, acetophenone derivatives, dialkoxyacetophenones, α-hydroxyketones, α-aminoketones, <NUM>-aroyl-<NUM>,<NUM>-dioxolanes, benzoin alkyl ethers and benzyl ketals, e.g. benzyl dimethyl ketal, ketosulfones, e. g <NUM>-[<NUM>-[(<NUM>-benzoyl-phenyl)-thio]-phenyl]-<NUM>-methyl-<NUM>-[(<NUM>-methyl-phenyl)-sulfonyl]-propan-<NUM>-one (Esacure® <NUM>, from IGM Resins B. ), <NUM>-ketocoumarins, for example as described in <CIT> and <CIT>, phenylglyoxylates and derivatives thereof, dimeric phenyl glyoxylates, peresters, e.g. benzophenonetetracarboxylic acid peresters, for example as described in <CIT>, acylphosphine photoinitiators (which can be chosen among mono-acylphosphine oxides, bis-acylphosphine oxides, tris-acylphosphine oxides and multifunctional mono- or bisacylphosphine oxides), halomethyltriazines, hexaaryl bisimidazole/coinitiator systems, e.g. ortho-chlorohexaphenylbisimidazole in combination with <NUM>-mercaptobenzothiazole, ferrocenium compounds or titanocenes, for example dicyclopentadienyl-bis(<NUM>,<NUM>-difluoro-<NUM>-pyrrolo-phenyl)titanium, O-acyloxime ester photoinitiators.

Examples of α-hydroxyketones and α-aminoketones are <NUM>-hydroxy cyclohexylphenyl ketone, <NUM>-hydroxy-<NUM>-methyl-<NUM>-phenyl-propane-<NUM>-one, <NUM>-[<NUM>-(<NUM>-hydroxyethoxy)phenyl]-<NUM>-hydroxy-<NUM>-methyl-<NUM>-propane-<NUM>-one, <NUM>-hydroxy-<NUM>-{<NUM>-[<NUM>-(<NUM>-hydroxy-<NUM>-methyl-propionyl)-benzyl]phenyl}-<NUM>-methyl-propane-<NUM>-one), <NUM>-hydroxy-<NUM>-{<NUM>-[<NUM>-(<NUM>-hydroxy-<NUM>-methylpropionyl)-phenoxy]-phenyl}-<NUM>-methyl-propan-<NUM>-one, <NUM>-methyl-<NUM>-(<NUM>-methylthiophenyl)-<NUM>-morpholinopropane-<NUM>-one), <NUM>-benzyl-<NUM>-dimethylamino-<NUM>-(<NUM>-morpholinophenyl)-butane-<NUM>-one, and (<NUM>-(dimethylamino)-<NUM>-[(<NUM>-methylphenyl)methyl]-<NUM>-[<NUM>-(<NUM>-morpholinyl) phenyl]-<NUM>-butanone).

Examples of O-acyloxime ester photoinitiators are <NUM>,<NUM>-octanedione,<NUM>-[<NUM>-(phenylthio)phenyl]-<NUM>-(O-benzoyloxime), ethanone <NUM>-[<NUM>-ethyl-<NUM>-(<NUM>-methylbenzoyl)-<NUM>-carbazole-<NUM>-yl] <NUM>-(O-acetyloxime) or those described in <CIT>.

Examples of acylphosphine photoinitiators include, but are not limited to, bis(<NUM>,<NUM>,<NUM>-trimethylbenzoyl)phenylphosphine oxide, bis(<NUM>,<NUM>-dimethoxybenzoyl)-<NUM>,<NUM>,<NUM>-trimethylpentyl phosphine oxide, bis(<NUM>,<NUM>,<NUM>-trimethylbenzoyl)-(<NUM>,<NUM>-dipentyloxyphenyl), <NUM>,<NUM>,<NUM>-trimethylbenzoyl-diphenyl phosphine oxide and ethyl (<NUM>,<NUM>,<NUM>-trimethylbenzoyl) phenylphosphinate, Phenyl(<NUM>,<NUM>,<NUM>-trimethylbenzoyl)phosphinic acid, glycerol ethoxylated trimester (Omnipol® TP from IGM Resins B. Examples of the halomethyltriazines based photoinitiators are <NUM>-[<NUM>-(<NUM>-methoxy-phenyl)-vinyl]-<NUM>,<NUM>-bis-trichloromethyl [<NUM>,<NUM>,<NUM>]triazine, <NUM>-(<NUM>-methoxy-phenyl)-<NUM>,<NUM>-bis-trichloromethyl [<NUM>,<NUM>,<NUM>]triazine, <NUM>-(<NUM>,<NUM>-dimethoxyphenyl)-<NUM>,<NUM>-bis-trichloromethyl [<NUM>,<NUM>,<NUM>]triazine, <NUM>-methyl-<NUM>,<NUM>-bis-trichloromethyl [<NUM>,<NUM>,<NUM>] triazine.

Cationic photoinitiators can be also used as the further photoinitiators (e), when the photocurable compositions according to the invention are used in hybrid systems (which in this connection mean mixtures of free- radically and cationically curing systems). Examples of suitable cationic photoinitiators are aromatic sulfonium, phosphonium or iodonium salts, as described e.g. in <CIT>, or cyclopentadienylarene-iron(II) complex salts, e.g. (η<NUM>-isopropylbenzene)(η<NUM>-cyclopentadienyl) iron(II) hexafluorophosphate or photolatent acids based on oximes, as described, for example, in <CIT>, <CIT>, <CIT>, <CIT> and <CIT>.

Additives (f) can be, for example, thermal initiators, binders, stabilizers, and mixture thereof.

The photocuring process according to the invention, especially in the case of pigmented compositions, may also be assisted by the addition, as additional additive (f), of a thermal initiator, a compound that forms free radicals when heated, e.g. an azo compounds, such as <NUM>,<NUM>'-azobis(<NUM>-methoxy-<NUM>,<NUM>-dimethylvaleronitrile), a triazene, diazosulfide, pentazadiene or a peroxy compound, for example a hydroperoxide or peroxycarbonate, e.g. tert-butyl hydroperoxide, as described e.g. in <CIT>.

Binders may also be added to the photocurable composition of the invention. The addition of binders is particularly advantageous when the photocurable compounds are liquid or viscous substances. The amount of binder may be, for example, from <NUM> to <NUM>% by weight, preferably from <NUM> to <NUM>% by weight, based on the total weight of the composition. The choice of binder is made in accordance with the field of use and the properties required therefor, such as developability in aqueous and organic solvent systems, adhesion to substrates and sensitivity to oxygen.

Suitable binders are, for example, polymers having a weight average molecular weight (Mw) of approximately from <NUM>,<NUM> Da to <NUM>,<NUM>,<NUM> Da, preferably from <NUM>,<NUM> Da to <NUM>,<NUM>,<NUM> Da. Illustrative examples are: homo- and copolymers of acrylates and methacrylates, e.g. copolymers of methyl methacrylate/ethyl acrylate/methacrylic acid, poly(methacrylic acid alkyl esters), poly(acrylic acid alkyl esters); cellulose esters and ethers, such as cellulose acetate, cellulose acetate butyrate, methylcellulose, ethylcellulose, polyvinylbutyral, polyvinylformal, cyclised rubber, polyethers such as polyethylene oxide, polypropylene oxide, polytetrahydrofuran, polystyrene, polycarbonates, polyurethanes, chlorinated polyolefins, e.g. polyvinyl chloride, co-polymers of vinyl chloride/vinylidene chloride, co-polymers of vinylidene chloride with acrylonitrile, methyl methacrylate and vinyl acetate, polyvinyl acetate, co-poly (ethylene/vinyl acetate), polymers such as polycaprolactam and poly(hexamethylene adipamide), polyesters such as poly(ethylene glycol terephthalate) and poly(hexamethylene glycol succinate).

Suitable stabilizers are, for example, thermal inhibitors, such as hydroquinone, hydroquinone derivatives, p-methoxyphenol, β-naphthol or sterically hindered phenols, e.g. <NUM>,<NUM>-di(tert-butyl)-p-cresol, which prevent premature polymerization. In order to increase dark storage stability it is possible to use, for example, copper compounds, such as copper naphthenate, stearate or octoate, phosphorus compounds, for example triphenylphosphine, tributylphosphine, triethyl phosphite, triphenyl phosphite or tribenzyl phosphite, quaternary ammonium compounds, e.g. tetramethylammonium chloride or trimethylbenzylammonium chloride, or hydroxylamine derivatives, e.g. N,N-diethylhydroxylamine. For the purpose of excluding atmospheric oxygen during polymerization it is possible to add paraffin or similar wax-like substances which, being insoluble in the polymer, migrate to the surface at the beginning of the polymerization and form a transparent surface layer which prevents air from entering.

It is also possible to add a light stabilizer, such as UV absorbers, e.g. hydroxyphenylbenzotriazole, hydroxyphenylbenzophenone, oxalic acid amide or hydroxyphenyl-s-triazine type. Such components can be used on their own or in the form of mixtures, with or without the use of sterically hindered amines (HALS).

The photocurable compositions according to the invention may also comprise, as further additives (f), photoreducible dyes, e.g. a xanthene, benzoxanthene, benzothioxanthene, thiazine, pyronin, porphyrin or acridine dye, and/or radiation cleavable trihalomethyl compounds. These compounds are described, for example, in <CIT>.

Further customary additives (f) are, depending upon the intended use, optical brighteners, fillers, pigments, both white and colored pigments, colorants, antistatics, wetting agents or flow improvers. Additives conventionally used in the art, e.g. antistatics, flow improvers and adhesion enhancers, can also be used.

It is also possible for chain-transfer reagents conventionally used in the art to be added to the compositions according to the invention. Examples are mercaptans, amines and benzothiazole.

The composition of the invention may also comprise colorants and/or colored pigments. Depending upon the intended use, both inorganic and organic pigments may be used. Such additives are well known to the person skilled in the art; some examples are carbon black, iron oxides, such as iron oxide yellow, iron oxide red, chromium yellow, chromium green, nickel titanium yellow, ultramarine blue, cobalt blue, bismuth vanadate, cadmium yellow and cadmium red. Examples of organic pigments are mono- or bis-azo pigments, and also metal complexes thereof, phthalocyanine pigments, polycyclic pigments, e.g. perylene, anthraquinone, thioindigo, quinacridone or triphenylmethane pigments, and also diketo-pyrrolo-pyrrole, isoindolinone, e.g. tetrachloroisoindolinone, isoindoline, dioxazine, benzimidazolone and quinophthalone pigments. The pigments may be used in the formulations on their own or in admixture.

Depending upon the intended use, the pigments can be added to the formulations in amounts conventionally used in the art, for example in an amount from <NUM> to <NUM>% by weight or from <NUM> to <NUM>% by weight, based on the total weight of the composition.

The composition may also comprise, for example, organic colorants of an extremely wide variety of classes. Examples are azo dyes, methine dyes, anthraquinone dyes and metal complex dyes. Usual concentrations are, for example, from <NUM> to <NUM>% wt, especially from <NUM> to <NUM>% wt, based on the total weight of the composition.

The choice of additives is governed by the field of use in question and the properties desired for that field. The additives (f) described above are known in the art and are accordingly used in the amounts conventionally used in the art.

The photocurable compositions of the invention may comprise water.

The photocurable compositions of the invention are suitable for various purposes, for example as a printing ink, such as screen printing inks, flexographic printing inks, offset printing inks and inkjet printing inks, as clearcoats, as colored coats, for example for wood or metal, as powder coatings, as coating materials inter alia for paper, wood, metal or plastics, as daylight-curable paints for marking structures and roads, for photographic reproduction processes, for holographic recording materials, for image-recording processes or in the production of printing plates that can be developed using organic solvents or using aqueous-alkaline media, for the production of masks for screen printing, as dental filling compounds, as adhesives, as pressure-sensitive adhesives, as laminating resins, as photoresists, e.g. galvanoresists, as etch resists or permanent resists, both liquid and dry films, as photostructurable dielectrics, and as solder masks for electronic circuits, as resists in the production of color filters for any type of display screen or in the creation of structures during the manufacture of plasma displays and electroluminescent displays, in the production of optical switches, optical gratings (interference gratings), in the manufacture of three-dimensional articles by bulk curing (UV curing in transparent moulds) or according to the stereolithography process, as described, for example, in <CIT>, in the manufacture of composite materials (e.g. styrene polyesters which may include glass fibers and/or other fibers and other adjuvants) and other methods of printing in three dimensions well-known to one skilled in the art, in the coating or sealing of electronic components or as coatings for optical fibers.

The photocurable compositions of the invention are also suitable for the production of optical lenses, e.g. contact lenses or Fresnel lenses, in the manufacture of medical apparatus, aids or implants, in dry film paints. The photocurable compositions of the invention are also suitable for the preparation of gels having thermotropic properties. Such gels are described for example in <CIT> and <CIT>.

Any article comprising a compound of formulas (I) or (Ia) or a photocurable compositions of the invention represents a further subject-matter of the invention.

The compounds and compositions according to the invention may also be used as free-radical photoinitiators or photoinitiating systems for radiation-curable powder coatings.

The photocurable compositions according to the invention are suitable, for example, as coating materials for all kinds of substrate, for example wood, textiles, paper, ceramics, glass, plastics, such as polyesters, polyethylene terephthalate, polyolefins and cellulose acetate, especially in the form of films, and also metals, such as Al, Cu, Ni, Fe, Zn, Mg or Co and GaAs, Si or SiOz, to which a protective layer is to be applied or an image is to be applied e.g. by imagewise exposure.

According to another of its aspects, it is a further subject-matter of the invention a process for photocuring photopolymerizable compositions and inks, which process comprises:.

According to a preferred embodiment, the photopolymerizable composition used in step (i) above comprises at least (a), (b) and (d).

A large number of the most varied kinds of light source may be used, the light source emitting at wavelengths from approximately <NUM> to approximately <NUM>. Both point sources and planiform radiators (lamp carpets) are suitable. Examples are: carbon arc lamps, xenon arc lamps, medium pressure, high pressure and low pressure mercury arc radiators, doped, where appropriate, with metal halides (metal halide lamps), microwave-excited metal vapour lamps, excimer lamps, superactinic fluorescent tubes, fluorescent lamps, argon incandescent lamps, flash lamps, photographic floodlight lamps, light-emitting diodes (LED), electron beams, X-rays and lasers.

According to one embodiment, said light source comprises UV light in at least one of the UVA, UVB and UVC ranges.

According to a preferred embodiment, said light source is a LED source, particularly preferred are LED light source emitting at wavelengths comprised between <NUM> and <NUM>, more preferably at <NUM>, <NUM> and <NUM>.

According to the invention the distance between the lamp and the substrate to be exposed may vary according to the intended use and the type and strength of the lamp, e.g. from <NUM> to <NUM>, preferably from <NUM> to <NUM>.

Said photopolymerizable composition may also be applied over a substrate already comprising a coated or printed layer. Said photopolymerizable composition may, after photopolymerization with said light source, be overprinted or overcoated with one or more compositions suitable for printing or coating.

The article obtained by applying said photopolymerizable composition to said substrate by said means of coating or printing, and photopolymerizing by said light source, with or without further elaboration of the article by further coating or printing, represents a further subject-matter of this invention.

As said, we surprisingly found that compounds of formulas (I) and (Ia) are effective as photoinitiatiors and their activity was measured for the first time. Moreover, we found that compounds of formulas (I) and (Ia) are very reactive with LED lamps both in clear and pigmented systems.

The invention is illustrated in detail below by the following examples, which are illustrative and not limiting.

In case of inconsistencies between the chemical name and the chemical structure herein indicated, the chemical structure prevails.

The wavy bond
<CHM>
means that both cis and trans isomerism is possible.

<NUM> NMR spectra were recorded with a Bruker Avance <NUM> or a Bruker DMX <NUM> or a Bruker DMX <NUM>.

Infrared spectra were recorded with a FT-IR <NUM> - Jasco.

<NUM> (<NUM> mmoles) of m-Anisidine and <NUM> (<NUM> mmoles) of Ethyl benzoylacetate were dissolved in <NUM> of N,N-Dimethylformamide. The reaction mixture was stirred at <NUM> for <NUM> hours eliminating ethanol by distillation. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of <NUM> hydrochloric acid and extracted with <NUM> of diethyl ether.

The organic layer was washed with <NUM> (x2) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of a yellow oil (yield <NUM>%).

<NUM>H-NMR (CDCl<NUM>, δ ppm): <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (t, <NUM>), <NUM> (s, <NUM>), <NUM> (t, <NUM>), <NUM> (t, <NUM>), <NUM> (d, <NUM>), <NUM> (br s, <NUM>).

To a warm solution of <NUM> (<NUM> mmoles) of Example <NUM> and <NUM> (<NUM> mmoles) of trans-Cinnamaldehyde in <NUM> of toluene were added in sequence <NUM> (<NUM> mmoles) of piperidine, <NUM> (<NUM> mmoles) of acetic acid and <NUM> of anhydrous sodium sulfate. The reaction mixture was refluxed for <NUM> hour under nitrogen atmosphere. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of brine and extracted with <NUM> of ethyl acetate. The organic layer was washed with <NUM> (x3) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of crude as a mixture of two regioisomers.

The product obtained was dissolved in <NUM> od anhydrous Tetrahydrofuran, cooled at <NUM>, and <NUM> (<NUM> mmoles) of Potassium tert-butoxide were slowly added in portions under stirring. After stirring for <NUM> minutes, <NUM> (<NUM> mmoles) of Iodomethane were cautiously added to the reaction. Then the resulting mixture was stirred at room temperature for <NUM> hours under nitrogen atmosphere. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was poured into <NUM> of ammonium chloride saturated solution, diluted with <NUM> of water and extracted with <NUM> of ethyl acetate. The organic layer was washed with <NUM> (x2) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of crude. The crude was used in the next step without any further purification.

<NUM> (<NUM> mmoles) of aluminum chloride were slowly added in portions under stirring to a solution of <NUM> (<NUM> mmoles as crude) of Example <NUM> in <NUM> of chlorobenzene. The resulting mixture was gradually heated to <NUM> and then stirred at this temperature for <NUM> hours. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of ice-water and extracted with <NUM> (x4) of dichloromethane/methanol (<NUM>:<NUM>). The organic layers were collected and the solvent removed by distillation under vacuum. The crude product was treated with <NUM> of toluene/cyclohexane (<NUM>:<NUM>), made to solidify and the solid washed under stirring at <NUM> for <NUM> minutes. Then the mixture was allowed to cool and the solid recovered by filtration obtaining <NUM> of an off-white solid (yield <NUM>%).

<NUM>H-NMR (DMSO-d<NUM>, δ ppm): <NUM> (s, <NUM>), <NUM> (dd, <NUM>), <NUM> (d, <NUM>), <NUM> (t, <NUM>), <NUM> (t, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>).

To a solution of <NUM> (<NUM> mmoles) of the product prepared in the Example <NUM> in <NUM> of N,N-Dimethylformamide were added in sequence <NUM> (<NUM> mmoles) of potassium carbonate, <NUM> (<NUM> mmoles) of sodium iodide and <NUM> (<NUM> mmoles) of <NUM>-Ethylhexyl bromide. The reaction mixture was stirred at <NUM> for <NUM> hours. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of water and extracted with <NUM> of toluene. The organic layer was washed with <NUM> (x3) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum. The crude product was purified by flash column chromatography on silica gel (petroleum ether/ethyl acetate <NUM>:<NUM>) followed by crystallization from cyclohexane obtaining <NUM> of a white solid (yield <NUM>%).

<NUM>H-NMR (CDCl<NUM>, δ ppm): <NUM>-<NUM> (m, <NUM>), <NUM> (m, <NUM>), <NUM>-<NUM> (m, <NUM>), <NUM> (m, <NUM>), <NUM> (s, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (dd, <NUM>), <NUM> (t, <NUM>), <NUM> (m, <NUM>),<NUM> (d, <NUM>), <NUM> (s, <NUM>).

<NUM> (<NUM> mmoles) of aluminum chloride were slowly added in portions under stirring to an ice-cooled solution of <NUM> (<NUM> mmoles) of Isobutylbenzene and <NUM> (<NUM> mmoles) of acetyl chloride in <NUM> of dichloromethane. The resulting mixture was stirred at room temperature for <NUM> hour under nitrogen atmosphere. After completion of the reaction, the mixture was poured into <NUM> of ice-water. The organic layer was separated, washed twice with water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of a pale-yellow oil (yield <NUM>%).

<NUM>H-NMR (CDCl<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>).

<NUM> (<NUM> mmoles) of sodium methoxide were slowly added portionwise in <NUM> minutes under stirring at <NUM> to a mixture of <NUM> (<NUM> mmoles) of Example <NUM> and <NUM> (<NUM> mmoles) of dimethyl carbonate in <NUM> of toluene. The mixture was stirred at <NUM> for <NUM> hour eliminating methanol by distillation. After stirring for <NUM> hour, additional <NUM> (<NUM> mmoles) of dimethyl carbonate in <NUM> of toluene were added to the mixture. Then the temperature was allowed to rise again to <NUM> and additional <NUM> (<NUM> mmoles) of sodium methoxide were slowly added portionwise in <NUM> minutes. The mixture was stirred at <NUM> for further <NUM> hour eliminating methanol by distillation. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of <NUM>% hydrochloric acid and extracted with <NUM> of ethyl acetate. The organic layer was washed with <NUM> (x2) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of a yellow oil (yield <NUM>%).

<NUM>H-NMR (CDCl<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>).

<NUM> (<NUM> mmoles) of <NUM>,<NUM>-Dimethoxyaniline and <NUM> (<NUM> mmoles) of Example <NUM> were dissolved in <NUM> of N,N-Dimethylformamide. The reaction mixture was stirred at <NUM> for <NUM> hours eliminating methanol by distillation. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, diluted with <NUM> of toluene/ethyl acetate (<NUM>:<NUM>) and poured into <NUM> of <NUM> hydrochloric acid. The organic layer was separated and washed with <NUM> (x3) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of a grey solid (yield <NUM>%).

<NUM>H-NMR (CDCl<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (d, <NUM>), <NUM> (dd, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (br s, <NUM>).

To a warm solution of <NUM> (<NUM> mmoles) of Example <NUM> and <NUM> (<NUM> mmoles) of trans-Cinnamaldehyde in <NUM> of toluene were added in sequence <NUM> (<NUM> mmoles) of piperidine, <NUM> (<NUM> mmoles) of acetic acid and <NUM> of anhydrous sodium sulfate. The reaction mixture was refluxed for <NUM> hour under nitrogen atmosphere. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of brine and extracted with <NUM> (x2) of dichloromethane. The organic layer was washed with <NUM> (x3) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of crude as a mixture of two regioisomers. The crude was used in the next step without any further purification.

<NUM> (<NUM> mmoles) of Potassium tert-butoxide were slowly added in portions under stirring to an ice-cooled solution of <NUM> (<NUM> mmoles as crude) of Example <NUM> in <NUM> of anhydrous Tetrahydrofuran. After stirring for <NUM> minutes, <NUM> (<NUM> mmoles) of Iodomethane were cautiously added to the reaction. Then the resulting mixture was stirred at room temperature for <NUM> hours under nitrogen atmosphere. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was poured into <NUM> of ammonium chloride saturated solution, diluted with <NUM> of water and extracted with <NUM> of ethyl acetate. The organic layer was washed with <NUM> (x2) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of crude that was used directly in the next step.

<NUM> (<NUM> mmoles) of Methanesulfonic acid were slowly added under stirring to a solution of <NUM> (<NUM> mmoles as crude) of Example <NUM> in <NUM> of dichloromethane. After stirring for <NUM>-<NUM> minutes at room temperature, the reaction mixture was poured into <NUM> of water. The organic layer was separated and washed with <NUM> (x2) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum. The crude product was purified by flash column chromatography on silica gel (toluene/ethyl acetate <NUM>:<NUM>) followed by crystallization from cyclohexane obtaining <NUM> of an off-white solid (yield <NUM>%).

<NUM>H-NMR (CDCl<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (t, <NUM>), <NUM> (d, <NUM>), <NUM> (dd, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM>-<NUM> (m, <NUM>), <NUM> (d, <NUM>).

<NUM> (<NUM> mmoles) of Example <NUM> were dissolved under vigorous stirring into <NUM> (<NUM> mmoles) of Methanesulfonic acid. The reaction mixture was stirred at room temperature for <NUM> hours. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was poured into <NUM> of water and extracted with <NUM> of dichloromethane. The organic layer was washed in sequence with <NUM> of sodium hydrogen carbonate saturated solution and then with <NUM> of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum. The crude product was purified by flash column chromatography on silica gel (toluene/ethyl acetate <NUM>:<NUM>) followed by crystallization from cyclohexane/ethyl acetate (<NUM>:<NUM>) obtaining <NUM> of a white-yellow solid (yield <NUM>%).

<NUM>H-NMR (CDCl<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>).

<NUM> (<NUM> mmoles) of <NUM>-(Methylthio)aniline and <NUM> (<NUM> mmoles) of Example <NUM> were dissolved in <NUM> of N,N-Dimethylformamide. The reaction mixture was stirred at <NUM> for <NUM> hours eliminating methanol by distillation. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of <NUM> hydrochloric acid and extracted with <NUM> of diethyl ether. The organic layer was washed with <NUM> (x2) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of a yellow oil (yield <NUM>%).

<NUM>H-NMR (CDCl<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (s, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (d, <NUM>), <NUM> (t, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (d, <NUM>), <NUM> (br s, <NUM>).

<NUM> (<NUM> mmoles) of Potassium tert-butoxide were slowly added in portions under stirring to an ice-cooled solution of <NUM> (<NUM> mmoles as crude) of Example <NUM> in <NUM> of anhydrous Tetrahydrofuran. After stirring for <NUM> minutes, <NUM> (<NUM> mmoles) of Iodomethane were cautiously added to the reaction. Then the resulting mixture was stirred at room temperature for <NUM> hours under nitrogen atmosphere. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was poured into <NUM> of ammonium chloride saturated solution, diluted with <NUM> of water and extracted with <NUM> of ethyl acetate. The organic layer was washed with <NUM> (x2) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of crude. The crude was used in the next step without any further purification.

<NUM> (<NUM> mmoles) of aluminum chloride were slowly added in portions under stirring to a solution of <NUM> (<NUM> mmoles as crude) of Example <NUM> in <NUM> of chlorobenzene. The resulting mixture was gradually heated to <NUM> and then stirred at this temperature for <NUM> hour. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of ice-water and extracted with <NUM> dichloromethane. The organic layer was washed with <NUM> of water/brine (<NUM>:<NUM>), dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum. The crude product was purified by flash column chromatography on silica gel (toluene/ethyl acetate <NUM>:<NUM>) followed by crystallization from cyclohexane/ethyl acetate (<NUM>:<NUM>) obtaining <NUM> of a white solid (yield <NUM>%).

<NUM>H-NMR (CDCl<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (dd, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>).

<NUM> (<NUM> mmoles) of Aniline and <NUM> (<NUM> mmoles) of Example <NUM> were dissolved in <NUM> of N,N-Dimethylformamide. The reaction mixture was stirred at <NUM> for <NUM> hours eliminating methanol by distillation. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of <NUM> hydrochloric acid and extracted with <NUM> of diethyl ether. The organic layer was washed with <NUM> (x2) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of an off-white solid (yield <NUM>%).

<NUM>H-NMR (CDCl<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (t, <NUM>), <NUM> (d, <NUM>), <NUM> (t, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (br s, <NUM>).

<NUM> (<NUM> mmoles) of Example <NUM> were dissolved under vigorous stirring into <NUM> (<NUM> mmoles) of Methanesulfonic acid. The reaction mixture was stirred at <NUM> for <NUM> hours. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was poured into <NUM> of water and extracted with <NUM> of dichloromethane. The organic layer was washed with <NUM> (x2) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum. The crude product was purified by flash column chromatography on silica gel (toluene/ethyl acetate <NUM>:<NUM>) followed by crystallization from cyclohexane/ethyl acetate (<NUM>:<NUM>) obtaining <NUM> of a white solid (yield <NUM>%).

<NUM>H-NMR (DMSO-d<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM>-<NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM>-<NUM> (m, <NUM>), <NUM> (dd, <NUM>), <NUM> (s, <NUM>).

To a mixture of <NUM> (<NUM> mmoles) of Example <NUM> in <NUM> of N,N-Dimethylformamide were added <NUM> (<NUM> mmoles) of potassium carbonate. After stirring at room temperature for <NUM> minutes, <NUM> (<NUM> mmoles) of Methyl chloroacetate were added to the mixture. The reaction mixture was stirred at room temperature for <NUM> hours and then at <NUM> for <NUM> hours. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool and then poured into <NUM> of <NUM> hydrochloric acid. The resulting precipitate was removed by filtration, suspended in <NUM> of toluene and washed under stirring at <NUM> for <NUM> minutes. Then the mixture was allowed to cool and the solid recovered by filtration obtaining <NUM> of a white solid (yield <NUM>%).

<NUM>H-NMR (DMSO-d<NUM>, δ ppm): <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (dd, <NUM>), <NUM> (d, <NUM>),<NUM> (t, <NUM>), <NUM> (t, <NUM>), <NUM> (m, <NUM>), <NUM> (s, <NUM>).

<NUM> (<NUM> mmoles) of zirconium(IV) acetylacetonate were added under stirring to a warm mixture of <NUM> (<NUM> mmoles) of Example <NUM> and <NUM> (<NUM> mmoles) of polyethylene glycol <NUM> in <NUM> of toluene. The reaction mixture was stirred at <NUM> for <NUM> hours eliminating methanol by distillation. Then additional <NUM> (<NUM> mmoles) of zirconium(IV) acetylacetonate were added and the reaction mixture was stirred at <NUM> for further <NUM> hour eliminating methanol by distillation. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, dissolved in <NUM> of dichloromethane/EtOAc (<NUM>:<NUM>) and washed with <NUM> of <NUM> hydrochloric acid. The brown-dark precipitate obtained during the work-up was removed by filtration through a pad of celite and the phases were separated. The organic layer was washed with <NUM> (x4) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of a light brown-yellow oil (yield <NUM>%).

<NUM>H-NMR (DMSO-d<NUM>, δ ppm): <NUM>-<NUM> (m, <NUM>), <NUM>-<NUM> (m, <NUM>), <NUM> (m, <NUM>), <NUM> (s, <NUM>), <NUM> (dd, <NUM>), <NUM> (d, <NUM>), <NUM> (t, <NUM>), <NUM> (t, <NUM>), <NUM> (m, <NUM>), <NUM> (s, <NUM>).

<NUM> (<NUM> mmoles) of <NUM>,<NUM>-Dimethoxyaniline and <NUM> (<NUM> mmoles) of Example <NUM> were dissolved in <NUM> of N,N-Dimethylformamide. The reaction mixture was stirred at <NUM> for <NUM> hours eliminating methanol by distillation. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of <NUM> hydrochloric acid and extracted with <NUM> of ethyl acetate/toluene (<NUM>:<NUM>). The organic layer was separated and washed with <NUM> (x3) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of an off-white solid (yield <NUM>%).

<NUM>H-NMR (DMSO-d<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (t, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>).

To a warm solution of <NUM> (<NUM> mmoles) of Example <NUM> and <NUM> (<NUM> mmoles) of trans-Cinnamaldehyde in <NUM> of toluene were added in sequence <NUM> (<NUM> mmoles) of piperidine, <NUM> (<NUM> mmoles) of acetic acid and <NUM> of anhydrous sodium sulfate. The reaction mixture was refluxed for <NUM> hour under nitrogen atmosphere. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was allowed to cool, poured into <NUM> of brine and extracted with <NUM> of ethyl acetate. The organic layer was washed with <NUM> (x3) of water, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum obtaining <NUM> of crude as a mixture of two regioisomers. The crude was used in the next step without any further purification.

<NUM> (<NUM> mmoles) of Example <NUM> were dissolved under vigorous stirring into <NUM> (<NUM> mmoles) of methanesulfonic acid. The reaction mixture was stirred at room temperature for <NUM> hours. Progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was poured into <NUM> of cold water and extracted with <NUM> of dichloromethane. The organic layer was washed in with <NUM> of water and brine, dried over anhydrous sodium sulfate, filtered and the solvent removed by distillation under vacuum. The crude product was purified by flash column chromatography on silica gel (toluene/ethyl acetate <NUM>:<NUM>) followed by crystallization from cyclohexane/ethyl acetate (<NUM>:<NUM>) obtaining <NUM> of a white solid (yield <NUM>%).

<NUM>H-NMR (DMSO-d<NUM>, δ ppm): <NUM> (d, <NUM>), <NUM> (m, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (s, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (d, <NUM>), <NUM> (s, <NUM>).

The ketoquinolones of the invention, were compared with <NUM>,<NUM>-Bis(diethylamino)benzophenone (COMP-<NUM>).

The photopolymerizable compositions for the test were prepared dissolving the photoinitiators and the co-initiator, Esacure® EDB (IGM Resins B. ) at a concentration of <NUM>% by weight (wt) each in a mixture <NUM>:<NUM> wt of Ebecryl® <NUM> and Ebecryl® <NUM> (Allnex).

The photopolymerizable compositions placed in the sample lodgment of a FT-IR (FT-IR <NUM>-Jasco), were exposed to a LED lamp (<NUM>) located at a distance of <NUM> from the sample and at an angle of <NUM>°. IR spectra were acquired at constant time intervals during the photopolymerization and the reduction over the time of the area of the peaks at <NUM> and <NUM>-<NUM> assigned to the acrylic double bonds was determined using the IR software. This allows quantifying the degree of polymerization and therefore the efficiency of the photoinitiator.

The results expressed as % of polymerization over time, are reported in Table <NUM>.

These tests confirm that compounds of formulas (I) and (Ia) are very reactive as photoinitiators.

The photopolymerizable compositions for the test were prepared dissolving the photoinitiators and the co-initiator, Esacure® EDB (IGM Resins B. ) at a concentration of <NUM>% by weight (wt) each in a Cyan Inkjet Ink.

Claim 1:
A photocurable composition comprising:
a) from <NUM> to <NUM>%, preferably from <NUM> to <NUM>% by weight, based on the total weight of the composition, of at least one ethylenically unsaturated compound; and
b) from <NUM> to <NUM>%, preferably from <NUM> to <NUM>%, and more preferably from <NUM> to <NUM>% by weight, based on the total weight of the composition, of at least one compound of formula (I)
<CHM>
wherein:
R<NUM> is a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl.
Qui is a quinolone group of formula:
<CHM>
wherein:
R<NUM>, R<NUM>, R<NUM> and R<NUM> are, independently of one another, hydrogen, substituted or unsubstituted C1-C20 alkyl, -N(C1-C6 alkyl)<NUM>, piperidino, morpholino, piperazino, -O-Rs, -S-R<NUM>, -O-[CH<NUM>]n-COOR<NUM> or -S-[CH<NUM>]n-COOR<NUM> where n=<NUM>-<NUM> and R<NUM> is hydrogen, substituted or unsubstituted C1-C20 alkyl, C1-C50 alkyl which is interrupted by one or more oxygens and which may terminate with a hydroxy group, C1-C20 alkyl, C2-C12 alkenyl, substituted or unsubstituted aryl, heteroaryl or C5-C6 cycloalkyl;
R<NUM> is hydrogen, a hydroxy group or a C1-C4 alkyl group;
R<NUM> is hydrogen or a C1-C10 alkyl group;
or Qui is a substituted or unsubstituted benzo-quinolone group of formula:
<CHM>
<CHM>
<CHM>
wherein R<NUM> is hydrogen or a C1-C10 alkyl group and the star indicates the carbon atom which is bound to the keto group of formula (I).