Patent Description:
The nasal cavity comprises a variety of surfaces that correspond to anatomic structures directly and indirectly serving various respective biological functions. Generally, the nasal cavity is divided vertically by a wall of cartilage called the septum. On each side of the septum is a nostril through which the nasal cavity can be accessed. Opposite the septum, on each lateral side of the nasal cavity, are a series of turbinates (also known as concha). Each series comprises an inferior, middle, and superior turbinate, as one goes in a posterior direction from the nostrils, through the nasal cavity, towards the throat. These turbinates are a series of bony ridges that protrude into the nasal cavity. The maxillary, anterior ethmoid, and frontal sinuses drain into the nasal cavity from under the middle turbinate, which is above the inferior turbinate.

In order to treat these anatomic structures within the nose, therapeutic fluids can be topically applied to their corresponding surfaces via a process called local intranasal drug delivery. Such fluids for example, include saline, antihistamines, decongestants, and corticosteroids, which may be helpful in irrigating nasal passages, treating allergies, relieving nasal congestion, and treating inflammation, respectively. The fluids can also include one or more drugs. Additionally, the nasal mucosa can serve as a non-invasive drug delivery pathway to the brain via nose-to-brain intranasal drug delivery and to the systemic circulation via systemic intranasal drug delivery, which overcomes anatomical and physiological barriers such as the blood-brain barrier and first-pass metabolism, respectively. Collectively, the intranasal drug delivery provides an optimized and targeted method for delivering therapies, including monoclonal antibody therapies, which are represented by therapeutic classes such as respiratory, central nervous system, gastrointestinal, dermatological, and others.

To deliver these fluids to various surfaces in the nasal cavity, a spray bottle is often used. To use the spray bottle, a patient typically inserts a nozzle through their nostril and ejects fluid from the nozzle in a haphazard and indiscriminate fashion. While haphazardly and indiscriminately dispensing fluid in this fashion tends to result in at least some fluid being applied to an appropriate surface within the nasal cavity, such an approach is inefficient at best. Indeed, a large percentage of the fluid delivered by this method is often wasted by being applied to surfaces for which the fluid can deliver little to no therapeutic value. Examples of the related art are disclosed in <CIT>), <CIT> and <CIT>). <CIT> discloses a nasal sprayer with a dispensing assembly comprising a first applicator in the form of a spray nozzle and a second applicator in the form of a flexible tube adapted for dispensing liquid to deeper regions, such as the Eustachian tube or the adenoid or sinus regions. The dispensing assembly comprises a housing attachable to a pump assembly and a receptacle for receiving a volume of a liquid medicament. A rotating valve member is rotatably received within a central channel of the housing for providing selective fluid communication between the selected one of the first and second applicators and the pump assembly.

The invention is defined in the independent claim <NUM>. Preferred embodiments are matter of the dependent claims.

One aspect is directed to a device to deliver fluid from a container to a nasal cavity. The device includes a selector with a receptacle sized to extend over a top of the container and having an opening sized to align with an outlet in the container. A nozzle is connected to the selector. The nozzle includes: first and second passages that are spaced apart and that each include a proximal end towards the selector and an opposing distal end; one or more first openings in communication with the first passage and positioned at a first lateral side of the nozzle; and one or more second openings in communication with the second passage and positioned at an opposing second lateral side of the nozzle. The nozzle is rotatable relative to the selector between first and second positions. The first position includes the first passage aligned with the outlet in the container to receive the fluid from the container and deliver the fluid through the first passage and out through the one or more first openings and with the second passage positioned away from the outlet. The second position includes the second passage aligned with the outlet in the container to receive the fluid from the container and to deliver the fluid through the second passage and out through the second openings and with the first passage positioned away from the outlet.

In another aspect, the first and second passages are fixedly positioned relative to each other within the nozzle.

In another aspect, the nozzle includes a base that connects to the selector and an extension that extends outward from the base in a direction away from the selector with the first and second passages extending through the extension.

In another aspect, the extension includes an elongated sectional shape with a major axis and a minor axis with the first and second passages being positioned along the major axis.

In another aspect, the selector includes a top face and a side wall that form the receptacle with the opening extending through the side wall and the top face.

In another aspect, the opening extends along the top face inward from the side wall and terminates at a back edge with the back edge being positioned away from a center point of the top face.

In another aspect, flanges extend from each of the selector and the nozzle and engage together to rotatably connect the selector to the nozzle.

In another aspect, filler rods are positioned within each of the first passage and the second passage with the filler rods including smaller sectional sizes than the first passage and the second passage to limit an open area of the first passage and the second passage.

In another aspect, the nozzle has a curved section with a length of <NUM>-<NUM> centimeters and has <NUM>°- <NUM>° of curvature.

In another aspect, the length of the curved section is between <NUM>-<NUM> centimeters and the curvature is <NUM>°- <NUM>°.

In another aspect, a recess extends into a distal end of the nozzle and the distal ends of the first and second passages terminate in the recess and are spaced inward from the distal end of the nozzle.

One aspect is directed to a device to deliver fluid from a container to a nasal cavity. The device includes a selector and a nozzle that are connected together and configured to connect to the container. The selector includes an opening configured to align with an outlet in the container. The nozzle includes: a base and an outwardly-extending extension with the extension including a length measured between a proximal end at the base and an opposing distal end; a first passage that extends along the extension and includes a first inlet at the base and first openings that face just towards the distal end and a first lateral side of the extension to expel the fluid from the first openings and to prevent the fluid from being expelled from a second lateral side of the extension; a second passage spaced away from the first passage and that extends along the extension and includes a second inlet at the base and second openings that face just towards the distal end and the second lateral side of the extension to expel the fluid from the second openings and to prevent the fluid from being expelled from the first lateral side of the extension. The nozzle is rotatable relative to the selector between a first position to align the first passage with the outlet in the container and the second being misaligned with the outlet, and a second position to align the second passage with the outlet in the container and the first passage being misaligned with the outlet.

In another aspect, one of the first openings extends through the distal end of the extension and one of the second openings extends through the distal end of the extension.

In another aspect, a recess extends into a distal end of the nozzle and the first and second passages terminate in the recess and are spaced inward from the distal end of the nozzle.

In another aspect, the first position includes the first inlet aligned with the outlet in the container to receive the fluid from the container and deliver the fluid through the first passage and out through the first openings, and the second position includes the second inlet aligned with the outlet in the container to receive the fluid from the container and to deliver the fluid through the second passage and out through the second openings.

In another aspect, the selector includes a top face and a side wall that extends outward from the top face with the opening including a slot that extends through the side wall and a portion of the top face.

In another aspect, the first passage and the second passage extend along the length of the extension in a side-by-side arrangement.

In another aspect, the first passage and the second passage are fixedly positioned within the extension and remain stationary relative to each other in each of the first position and the second position.

In another aspect, filler rods are positioned in the first and second passages to reduce an open interior space within the first and second passages.

One aspect is directed to a method (not claimed) of delivering fluid from a container to a nasal cavity The method includes rotating a nozzle relative to a selector to a first position and aligning a first passage of the nozzle with an outlet of the container while the nozzle is connected to the selector and both the nozzle and the selector are connected to the container. The method includes directing the fluid that is expelled from the container through the first passage that extends along the length of the nozzle and out through first openings that face outward towards a distal end and a first lateral side of the nozzle. The method includes while in the first position positioning a second passage of the nozzle away from the outlet and preventing the fluid from being moved into the second passage and preventing the fluid from being expelled outward from a second lateral side of the nozzle. The method includes rotating the nozzle relative to the selector to a second position and aligning a second passage of the nozzle with the outlet of the container while the nozzle is connected to the selector and both the nozzle and the selector are connected to the container. The method includes directing the fluid that is expelled from the container through the second passage that extends along the length of the nozzle and out through second openings that face outward towards the distal end and a second lateral side of the nozzle. The method includes while in the second position positioning a first passage of the nozzle away from the outlet and preventing the fluid from being moved into the first passage and preventing the fluid from being expelled outward from the first lateral side of the nozzle.

In another aspect, the method includes aligning a spout at the outlet of the container within a slot in the selector and connecting the selector and the nozzle to the container with the spout extending beyond the selector and being contained within the nozzle.

In another aspect, the method includes positioning a first filler rod within the first passage and reducing a size of the first passage prior to connecting the selector and the nozzle to the container and positioning a second filler rod within the second passage and reducing a size of the second passage prior to connecting the selector and the nozzle to the container.

In another aspect, the method includes aligning the selector relative to the container with the outlet being positioned laterally away from a centerline of the selector.

In another aspect, the method includes laterally connecting the selector to the container and inserting a spout of the container through a slot in the selector.

In another aspect, the method includes expelling the fluid from each of the first and second passages into a recess that extends into the distal end of the nozzle.

The various aspects of the various embodiments may be used alone or in any combination, as is desired.

The present application is directed to devices and methods for delivering fluid from a container to the nasal cavity. <FIG> schematic illustrates a device <NUM> for delivering fluid. The device <NUM> includes a selector <NUM> and a nozzle <NUM> that are connected together and rotatable relative to each other. The selector <NUM> and nozzle <NUM> are further configured to be connected to a container that holds the fluid (not illustrated in <FIG>). The selector <NUM> includes an opening <NUM> that aligns with a corresponding opening in the container. The nozzle <NUM> includes a first passage <NUM> with one or more openings <NUM> on a lateral side, and a second passage <NUM> with one or more openings <NUM> on an opposing lateral side. The selector <NUM> and nozzle <NUM> can be positioned at a first rotational position with the first passage <NUM> aligned with the opening <NUM> to receive the fluid and direct it through the one or more openings <NUM> on the first lateral side. The selector <NUM> and nozzle <NUM> can be positioned at a second rotational position with the second passage <NUM> aligned with the opening <NUM> to receive and direct the fluid through the one or more openings <NUM> on the second lateral side. One or more openings can also be positioned at a distal end <NUM> to direct fluid distally outward in one or both of the first and second positions.

<FIG> illustrates a side view of a device <NUM> connected to a container <NUM>. <FIG> illustrates an exploded view of the device <NUM> and container <NUM>. The device <NUM> includes a selector <NUM> that connects to the container <NUM>. A nozzle <NUM> is connected to the selector <NUM> and extends outward from an opposing side away from the container <NUM>. The nozzle <NUM> is sized to be inserted into the nasal cavity and direct the fluid.

The device <NUM> provides for dispensing and directing the fluid from the container <NUM> to selective positions within the nasal cavity. The fluid can be dispensed as a rinse or as a spray. The container <NUM> includes a body <NUM> with an enclosed interior that contains the fluid and an open end. An outlet <NUM> provides for outputting the fluid from the container <NUM>. The outlet <NUM> can be positioned within a spout <NUM> that is connected to one end of the body <NUM>. A tube (not illustrated) can be positioned within the interior of the body <NUM>. A first end of the tube is attached at the outlet <NUM> and a second end is positioned in a lower section and/or bottom of the interior. The tube provides for collecting the fluid from the interior and moving it to the outlet <NUM>.

The device <NUM> can contain a variety of different fluids and can include drugs to support local intranasal drug delivery, systemic intranasal drug delivery, and nose-to-brain intranasal drug delivery. Fluids include but are not limited to saline, antihistamines, decongestants, and corticosteroids. Drugs include but are not limited to therapies, including monoclonal antibody therapies, that are represented by therapeutic classes such as respiratory, central nervous system, gastrointestinal, dermatological, and others.

One or more gaskets <NUM> can be positioned to prevent the fluid from leaking. The gaskets <NUM> can include various shapes and sizes to accommodate the shape and dimensions of the device <NUM>. <FIG> includes a first gasket <NUM> having an annular shape and a second gasket <NUM> have a straight rod-like shape. In one example, the gaskets <NUM> are positioned between the selector and the nozzle <NUM> to prevent fluid from leaking. The annular gasket <NUM> is positioned in the receptacle <NUM> in proximity to the proximal end <NUM> and the first and second passages <NUM>, <NUM>. The straight gasket <NUM> is positioned at the proximal end <NUM> between the first and second passages <NUM>, <NUM> to prevent the fluid from inadvertently entering one of the passages <NUM>, <NUM>.

The selector <NUM> is configured to connect to the container <NUM>. <FIG> illustrates a top view of the selector <NUM>, and <FIG> illustrates a bottom view. The selector <NUM> includes a top face <NUM> and side wall <NUM> that form a receptacle <NUM>. An opening <NUM> extends through a section of the top face <NUM> and is sized to receive the spout <NUM>. The opening <NUM> can be isolated to just the top face <NUM>. Additionally or alternatively, the opening <NUM> can be a slot that extends through a section of the top face <NUM> and the side wall <NUM>. The slot can facilitate attaching the selector <NUM> to the container <NUM> as the selector <NUM> can be moved in a lateral direction and snap fit onto the container <NUM> with the spout <NUM> being received in the slot.

In a slot embodiment as illustrated in <FIG>, the slot opening <NUM> extends inward from the side wall <NUM>. The opening <NUM> extends along the top face <NUM> and terminates at a back edge <NUM>. The length L of the opening <NUM> measured between the side wall <NUM> and the back edge <NUM> can vary. The slot opening <NUM> is shaped and/or sized for the back edge <NUM> to be positioned away from a center line C that extends through the selector <NUM>. In one design as illustrated in <FIG>, the top face <NUM> includes a substantially circular shape that has a radius r. The length L of the opening <NUM> is different than the radius r. In one design as illustrated in <FIG>, the length L of the opening <NUM> is greater than the radius r. Other designs can include the length L being less than the radius r. In another design, the slot opening <NUM> extends into the top face <NUM> at an angle away from the centerline line C and with the back edge <NUM> away from the centerline C.

A tab <NUM> extends outward from the side wall <NUM>. In one design as illustrated in <FIG>, the tab <NUM> is positioned at a bottom of the side wall <NUM> with the top face <NUM> positioned at a top of the side wall <NUM>. The tab <NUM> can also be positioned at other locations along the height of the side wall <NUM>. The tab <NUM> provides a surface for the user to apply a force to move the selector <NUM> towards the container <NUM>, which is how the user directs the flow to the left or right, thus producing a unidirectional or multidirectional flow upwards through one or more openings <NUM> and in the direction selected. This force activates the container <NUM> and causes the fluid to be dispelled from the interior space of the body <NUM> and out through the outlet <NUM> and spout <NUM>.

A shelf <NUM> extends radially inward from an inner side of the side wall <NUM>. The shelf <NUM> provides for engaging with the spout <NUM> and/or body <NUM> of the container <NUM> to attach the selector <NUM>. As illustrated in <FIG>, the shelf <NUM> can be smaller at the opening <NUM>, and can be larger away from the opening <NUM>. As best illustrated in <FIG>, the shelf <NUM> can be largest between the back edge <NUM> and side wall <NUM> away from the opening <NUM>. This can coincide with the tab <NUM>.

One of more flanges <NUM> can extend radially outward from an outer side of the side wall <NUM>. The one or more flanges <NUM> provide for engaging with the nozzle <NUM>. In one design, a series of flanges <NUM> are spaced apart by gaps and positioned at various spacings around the side wall <NUM>. The flanges <NUM> can include the same or different shapes and/or sizes. In one design as illustrated in <FIG>, a pair of relatively small flanges <NUM> are positioned on opposing sides of the opening <NUM>. Larger flanges <NUM> are spaced apart around a remainder of the side wall <NUM>.

The nozzle <NUM> is attached to the selector <NUM>. The nozzle <NUM> includes a base <NUM> that engages with the selector <NUM> and an elongated extension <NUM> for insertion into a nasal passage of the user. As illustrated in <FIG> and <FIG>, the base <NUM> includes a top wall <NUM> and a side wall <NUM> that extends outward in one direction around the periphery. The top wall <NUM> provides a surface for the user to apply a force to move the selector <NUM> and nozzle <NUM> toward the container <NUM>, thus initiating the flow of fluid. The top wall <NUM> and side wall <NUM> form a receptacle <NUM> that receives the selector <NUM>. One or more flanges <NUM> can extend radially inward from the side wall <NUM>. The one or more flanges <NUM> engage with the selector <NUM> and/or the container <NUM> to attach the nozzle <NUM>. In one design, the flanges <NUM> on the nozzle <NUM> engage with the flanges <NUM> on the selector <NUM> to connect the nozzle <NUM> to the selector <NUM>. The circular sectional shape of the receptacle <NUM> provides for the nozzle <NUM> to be rotatable relative to the selector <NUM> to selectively position the nozzle <NUM> as various rotational positions.

The extension <NUM> extends outward from the base <NUM> away from the receptacle <NUM>. The extension <NUM> includes a proximal end <NUM> at the top wall <NUM> and an opposing distal end <NUM>. The extension <NUM> includes a curved shape that curves away from a centerline F of the base <NUM>. As illustrated in <FIG>, the curved shape results in the proximal end <NUM> being at or in closer proximity to the centerline F than the distal end <NUM>. The curved shape can extend along the entire length of the extension <NUM> between the proximal and distal ends <NUM>, <NUM>. The curved shape can be lesser at the proximal end <NUM> with a smaller radius b and greater at the distal end <NUM> with a greater radius d. The extension <NUM> can also include other shapes as necessary to deliver the fluid to the nasal cavity. One design includes a straight shape. In one design, the extension <NUM> has a curved section with a length between <NUM>-<NUM> centimeters. In one specific design, the curved section has a length between <NUM>-<NUM> centimeters. In one design, the curved section has a shape with a curvature of between <NUM>°-<NUM>°. In another design, the curvature is between <NUM>°-<NUM>°. In one specific design, the curvature is between <NUM>°-<NUM>°. In one specific design, the extension <NUM> has curved section with a length of between <NUM>-<NUM> centimeters and a curvature of between <NUM>°-<NUM>°.

As illustrated in <FIG>, first and second passages <NUM>, <NUM> extend through the extension <NUM>. The passages <NUM>, <NUM> are independent and separated along the extension <NUM>. Further, the passages <NUM>, <NUM> are fixed within the nozzle <NUM> and do not move relative to one another. Each passage <NUM>, <NUM> includes an inlet <NUM> at the proximal end <NUM>, and one or more openings <NUM>. The one or more openings <NUM> can be positioned along lateral sides of the extension <NUM> away from the distal end <NUM>. One or more of the openings <NUM> can extend through the distal end <NUM>. In one design, one or more openings <NUM> are positioned along each lateral side of the extension <NUM>, and two or more openings <NUM> are positioned at the distal end <NUM>. The multiple openings <NUM> along different sides of the extension <NUM> provides for dispersing the fluid in multiple directions from each of the passages <NUM>, <NUM>. In one design, fluid can be dispersed from the first passage <NUM> along the distal end <NUM> and one lateral side, and from the second passage <NUM> along the distal end <NUM> and an opposing lateral side.

As illustrated in <FIG>, the extension <NUM> includes an elongated sectional shape that includes a major axis x and a minor axis y. This elongated shape accommodates the first and second passages <NUM>, <NUM> that extend along the extension <NUM> in a side-by-side orientation. The elongated sectional shape further includes rounded corners to facilitate insertion into the nasal cavity.

In one example as illustrated in <FIG>, the first and second passages <NUM>, <NUM> extend the entire length of the extension <NUM> from the proximal end <NUM> to the distal end <NUM>. As illustrated, each passage <NUM>, <NUM> terminates at a separate opening <NUM> at the distal end <NUM>. In another example as illustrated in <FIG>, a recess <NUM> extends into the distal end <NUM> of the extension <NUM>. The recess can have a cupped shape with various depths. The distal end <NUM> at the recess <NUM> has rounded edges to facilitate insertion into the nasal cavity and to prevent damage to the nasal cavity that could be caused by sharper edges. Each passage <NUM>, <NUM> terminates at a separate opening <NUM> that is positioned in the recess <NUM> and is spaced inward from the distal end <NUM>.

The nozzle <NUM> is rotatably connected to the selector <NUM> and rotatable between a first position and a second position. <FIG> illustrates the nozzle <NUM> attached to the selector <NUM> and in the first position. This first position locates the inlet <NUM> of the first passage <NUM> with the outlet <NUM> in the spout <NUM> of the container <NUM>. When the user applies a force to the container <NUM>, the fluid is ejected from the outlet <NUM> of the spout <NUM> and enters into the first passage <NUM>. The fluid moves along the length of the first passage <NUM> and is expelled through the first openings <NUM>, either along just the first lateral side of the extension <NUM>, or along just the lateral side and the distal end <NUM>. Because the second passage <NUM> is not aligned with the outlet <NUM> of the spout <NUM> in the first position, the fluid is prevented from entering into the second passage <NUM>. Thus, fluid is dispersed just to a limited section of the user's nasal cavity when in this first position.

The nozzle <NUM> can also be rotated relative to the selector <NUM> to a second position. The second position locates the inlet <NUM> of the second passage <NUM> with the outlet <NUM> in the spout <NUM> of the container <NUM>. Fluid can be ejected from the outlet <NUM> of the spout <NUM> and into the second passage <NUM> and expelled through the openings <NUM> at either just the opposing lateral side, or just the opposing lateral side and the distal end <NUM>. In the second position, the first passage <NUM> is positioned away from the outlet <NUM> of the spout <NUM> and the fluid is prevented from entering into the first passage <NUM>.

The nozzle <NUM> can be positioned relative to the selector <NUM> in a third position. The third position can locate the inlets <NUM> of both the first passage <NUM> and the second passage <NUM> away from the spout <NUM>. The third position can be an off or closed position when the user does not want fluid to be dispensed through the nozzle <NUM>.

<FIG> illustrates a method of using the device <NUM> to deliver fluid to the nasal passages. The method includes rotating the nozzle <NUM> relative to the selector <NUM> in a first direction to a first position (block <NUM>). The first position aligns the first passage <NUM> of the nozzle <NUM> with the opening <NUM> of the selector <NUM>. This also aligns the first passage <NUM> with the outlet <NUM> of the spout <NUM> that extends from the container <NUM>. The movement of the nozzle <NUM> and selector <NUM> occurs while connected to the container <NUM>.

The container <NUM> is activated and fluid from the container <NUM> is enters into the inlet <NUM> of the first passage <NUM> and through the first passage <NUM> and out through one or more first openings <NUM> (block <NUM>). The one or more first openings <NUM> can be positioned just along a first lateral side of the extension <NUM>, or along the first lateral side and the distal end <NUM>. In this first position, the second passage <NUM> is positioned away from the outlet <NUM> of the spout <NUM>. This prevents the fluid from entering into the second passage <NUM>.

The nozzle <NUM> can be rotated relative to the selector <NUM> in a second direction to a second position (block <NUM>). The second position aligns the second passage <NUM> of the nozzle <NUM> with the opening <NUM> of the container <NUM> while the nozzle <NUM> is connected to the selector <NUM> and both the nozzle <NUM> and the selector <NUM> are connected to the container <NUM>. The second position also aligns the inlet <NUM> of the second passage <NUM> with the outlet <NUM> of the spout <NUM> of the container <NUM>.

While in the second position, the container <NUM> can be activated and the fluid from the container <NUM> enters into the inlet <NUM> of the second passage <NUM> and moves through the second passage <NUM> and out through the one or more second openings <NUM> (block <NUM>). The one or more second openings <NUM> can be positioned along just the opposing second lateral side of the extension <NUM>, or along both the second lateral side and the distal end <NUM>. In the second position, the first passage <NUM> is positioned away from the outlet <NUM> of the spout <NUM>. This prevents the fluid from entering into the first passage <NUM>.

Activation of the container <NUM> to dispel the fluid can occur in various manners. One design includes the user applying a downward force on the tab <NUM>. The interior of the container <NUM> can be pressurized and this downward force causes the outlet <NUM> to open thus allow for the pressurized fluid to move out through the outlet <NUM>. In another design, the downward force on the top wall <NUM> forces air into the interior of the container <NUM>. This introduced air displaces the fluid which is driven out through the outlet <NUM>. Another design provides for activation to be caused by the user squeezing the container <NUM>. This delivery forces the fluid from the interior of the container through the outlet <NUM>. Releasing the container <NUM> causes the container to move back to its original shape. Air is drawn into the interior of the container (such as through one or more openings in the selector <NUM>).

In one design, the first passage <NUM> and second passage <NUM> are sized to deliver the fluid to the nasal passages. The sectional sizes of the passages <NUM>, <NUM> can be the same or can be different. In one design, the passages <NUM>, <NUM> include an inner diameter of <NUM> at the distal end <NUM>. In another design, the inner diameter is within a range of <NUM>-<NUM>. Filler rods <NUM> can be positioned in one or both of the passages <NUM>, <NUM>. When present, the filler rods <NUM> reduce the cross-sectional area of the passages <NUM>, <NUM>. In this regard, the filler rods <NUM> may be useful for accelerating the fluid through the passages <NUM>, <NUM>. Although a similar effect may be obtained by sizing the passages <NUM>, <NUM> more narrowly and omitting the filler rods <NUM>, small diameter passages <NUM>, <NUM> may be difficult to manufacture, thereby making wider diameter passages in combination with the filler rods <NUM> advantageous in some circumstances.

As illustrated in <FIG>, the filler rods <NUM> are sized to be positioned within one or both of the passages <NUM>, <NUM>. In these designs, the passages <NUM>, <NUM> are manufactured with a larger sectional size than needed for delivering the fluid. To reduce the size, filler rods <NUM> are positioned in the passages <NUM>, <NUM>. The filler rods <NUM> include a smaller sectional size than the passages <NUM>, <NUM> and thus reduce the effective size to deliver a smaller amount of the fluid.

The filler rods <NUM> include a first end <NUM> and opposing second end <NUM>. The length of the filler rods <NUM> measured between the ends <NUM>, <NUM> can be the same or smaller than the length of the passages <NUM>, <NUM>. In one design, the filler rods <NUM> extend along the passages <NUM>, <NUM> with the ends <NUM> positioned proximally inward from the openings <NUM> on the lateral sides of the extension <NUM>.

<FIG> includes a device <NUM> with a selector <NUM> and a nozzle <NUM> that are connected together and also configured to be connected to the container <NUM>. The selector <NUM> includes an opening <NUM> (not illustrated in <FIG>) that receives the fluid from the container <NUM> as disclosed above. The nozzle <NUM> includes an extension <NUM> that includes a proximal section <NUM> and a distal section <NUM>. The distal section <NUM> is rotatable relative to the proximal section <NUM> as illustrated by arrows R-R. A single passage <NUM> extends through the extension <NUM> including both the proximal section <NUM> and the distal section <NUM>. One or more openings <NUM> are positioned on just one lateral side of the distal section <NUM>. One or more openings <NUM> can also be positioned on the distal end <NUM>.

In use, the distal section <NUM> is rotated to a first position with one or more openings <NUM> on the lateral side facing in a first lateral direction. The fluid is moved through the passage <NUM> and is expelled through the one or more openings <NUM> on just the first lateral side. Because the opposing second lateral side does not include openings <NUM>, no fluid is dispelled in that direction.

The user can then rotate the distal section <NUM> to a second position with the one or more openings <NUM> on the lateral side facing in the second lateral direction. Fluid can be moved through the passage <NUM> and expelled through the one or more openings on just the second lateral side.

In both the first and second positions, fluid can be expelled from the distal end <NUM> if the extension <NUM> includes one or more openings <NUM> on the distal end <NUM>.

The selector <NUM> and nozzle <NUM> can be constructed from various materials, including but not limited to plastics and rubber. In one design, the extension <NUM> is flexible to facilitate insertion into the nasal cavity and prevent possible injury to the user.

The embodiments describe the device <NUM> being attached to a container <NUM>, such as a bottle. The device <NUM> may also be attached to various other types of containers <NUM>. Examples include but are not limited to a hose and a bag. The various containers <NUM> may be deformable by the user to force the fluid into the device <NUM>, or may be non-deformable and require delivery to the device <NUM> in other manners such as gravity with the user tipping the container <NUM> to move the fluid into the device <NUM>, and a pump that delivers the fluid from the container to the device <NUM>.

As disclosed above, the device <NUM> can include openings <NUM> along the lateral sides of the nozzle <NUM>. Openings <NUM> can also be positioned at the distal end <NUM>. As illustrated in <FIG>, the nozzle <NUM> can also include openings <NUM> at just the distal end <NUM> (i.e., there no openings <NUM> along the lateral sides of the nozzle <NUM>). Each of the openings <NUM> can be aligned with one or more of the openings <NUM> at the distal end <NUM>. In one design, a first opening <NUM> at the distal end <NUM> is aligned with the first passage <NUM> and a second opening <NUM> at the distal end <NUM> is aligned with the second passage <NUM>. The selector <NUM> can be positioned at a first rotational position to expel fluid just through the first passage <NUM> and first opening <NUM>, and positioned at a second rotational position to expel fluid through just the second passage <NUM> and the second opening <NUM>.

The various devices <NUM> may be used during surgical procedures on living patients. These may also be used in a non-living situation, such as within a cadaver, model, and the like. The non-living situation may be for one or more of testing, training, and demonstration purposes.

Spatially relative terms such as "under", "below", "lower", "over", "upper", and the like, are used for ease of description to explain the positioning of one element relative to a second element. These terms are intended to encompass different orientations of the device in addition to different orientations than those depicted in the figures. Further, terms such as "first", "second", and the like, are also used to describe various elements, regions, sections, etc. and are also not intended to be limiting. Like terms refer to like elements throughout the description.

Claim 1:
A device (<NUM>) to deliver fluid from a container (<NUM>) to a nasal cavity, wherein the device (<NUM>) comprises:
a selector (<NUM>) comprising a receptacle sized to extend over a top of the container (<NUM>) and an opening (<NUM>) sized to align with an outlet (<NUM>) in the container (<NUM>);
a nozzle (<NUM>) connected to the selector (<NUM>), the nozzle comprising:
first and second passages (<NUM>, <NUM>) that are spaced apart and that each include a proximal end (<NUM>) towards the selector (<NUM>) and an opposing distal end (<NUM>);
one or more first openings (<NUM>) in communication with the first passage (<NUM>), the first openings (<NUM>) positioned at a first lateral side of the nozzle (<NUM>);
one or more second openings (<NUM>) in communication with the second passage (<NUM>), the second openings (<NUM>) positioned at an opposing second lateral side of the nozzle (<NUM>);
the nozzle (<NUM>) being rotatable relative to the selector (<NUM>) between first and second positions, the first position comprising the first passage (<NUM>) aligned with the outlet (<NUM>) in the container (<NUM>) to receive the fluid from the container (<NUM>) and deliver the fluid through the first passage (<NUM>) and out through the one or more first openings (<NUM>) and with the second passage (<NUM>) positioned away from the outlet (<NUM>), and the second position including the second passage (<NUM>) aligned with the outlet (<NUM>) in the container (<NUM>) to receive the fluid from the container (<NUM>) and to deliver the fluid through the second passage (<NUM>) and out through the second openings (<NUM>) and with the first passage (<NUM>) positioned away from the outlet (<NUM>).