Patent Description:
Currently, many different types of double-agent essences exist on the market, including water and powder combination, white emulsion and transparent gelatin combination, semi-permeable gel and transparent gelatin combination, and the like. For example, Clarins' Double Serum on the market is a double-agent type of oil and water, which is packed in a large tube and a small tube and squeezed out by one pump head. Guerlain's ABEILLE ROYALE is a semi-permeable gelatin and lotion combination with particles, in which the semi-permeable gelatin and the lotion are packed in <NUM> tubes separately and squeezed out through <NUM> pump head. Clinique's dark spot corrector & optimizer is a combination of lotion and gelatin, in which the lotion and the gelatin are packed in <NUM> tubes separately, and when in use, squeezed out through two pump heads separately, and then mixed on the hand. Clinique's dramatically different moisturizing lotion + is a combination of white emulsion and transparent gelatin, in which the emulsion and the transparent gelatin are packed in a large tube and a small tube sleeved together and squeezed out through one pump head. Kanebo Cosmetics' Kanebo Twany Seasonal Essence AW is a bi-phase formula consisting of oil and water essences. <CIT> discloses a stabilized oil-based thickening gel composition comprising an anionic surfactant having a lipopeptide structure, water and/or a polyhydric alcohol having a valence of <NUM> or more, a tocopherol compound and an oil component, wherein the presence of tocopherol is essential for stabilizing the composition. Aminofect gel based on sodium surfactin is known for formulating oil gels in a ratio of <NUM> part Aminofect gel to <NUM> parts of oil. <CIT> discloses a double gel composition wherein the emulsifier is not sodium surfactin.

That is to say, the main combinations of the double-agent essences on the market are a combination of emulsion and transparent gelatin and a combination of emulsion and semi-permeable gelatin, which can provide a certain degree of moisture to the skin, so that the skin will not be too refreshed. Moreover, the active substances in the double-agent essence can be separated, so that mixing before use will not affect its stability.

However, the existing products on the market are basically a simple blend of double-agent essences. Although there are new ideas in the packaging, with two tubes for separate packing and separate discharge and also with in-tube mixing, the mixing of the basic materials have no significant difference, which is basically a transparent water-based gel with a semi-permeable to milky white oil-in-water essence. It is difficult to make the oil gel transparent, stable and good in skin feel, which has certain requirements for the selection of emulsifiers, the selection and matching of oil, and the selection of polyol.

In order to overcome the shortcomings of the prior art, a first object of the present application is to provide a double-agent essence composed of oil gel and hydrogel which are mixed in a preset any ratio during use and are both transparent and stable.

A second object of the present application is to provide a method for preparing a double-agent essence, in which oil gel and the hydrogel are prepared separately. The oil gel is prepared by a D-phase emulsification method. A low amount of emulsifier can emulsify an oil phase with a high oil content.

The objects of the invention are achieved as presented in the appended claims.

Compared with the prior art, the present application has the following beneficial effects.

The present application will be further described with reference to the accompanying drawings and specific embodiments hereinafter. It should be noted that the embodiments or technical features described hereinafter can be arbitrarily combined to form new embodiments without conflict.

A double-agent essence includes oil gel and hydrogel which are mixed according to a presetany ratio during use. The oil gel includes the following components in parts by weight% parts by weight: <NUM>-<NUM> parts of active ingredient; <NUM>-<NUM> parts of polyol; <NUM>-<NUM> part of SODIUM SURFACTIN; <NUM>-<NUM> parts of oil; and <NUM>-<NUM> parts of water.

SODIUM SURFACTIN is selected as an emulsifier, which comes from nature and is fermented by Bacillus subtilis. As shown in <FIG>, it is a circular polypeptide composed of seven amino acids. It is a green and natural polypeptide emulsifier, mild to the skin, has an anti-inflammatory effect, can improve skin permeability and has a very high emulsifying ability. A dosage as low as <NUM>% can emulsify <NUM>% or even higher oil.

Water is mainly used to adjust the refractive index of the oil-water phase of the formula.

As a further embodiment, the active ingredient includes <NUM>-<NUM> part of LAMINARIA OCHROLEUCA extract complex, <NUM>-<NUM> part of algae extract complex, <NUM>-<NUM> parts of complex amino acid, <NUM>-<NUM> part of eye circumference mixture. The LAMINARIA OCHROLEUCA extract complex is a composition of caprylic/capric triglyceride and LAMINARIA OCHROLEUCA extract. The algae extract complex is a composition of caprylic/capric triglyceride and algae extract. The complex amino acid is a composition of water, butylene glycol, lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, valine, isoleucine, leucine, tyrosine and phenylalanine. The LAMINARIA OCHROLEUCA extract is derived from the "golden seaweed" living in the harsh marine environment. Under the influence of various factors such as the internal and external salinity changes, seawater immersion/non-immersion changes and changes in the intensity of sunlight, the LAMINARIA OCHROLEUCA has formed a unique survival mechanism. It mainly has active ingredients with comprehensive anti-inflammatory, anti-aging and sun-protection functions.

In addition, the eye circumference mixture is a composition of CAPSICUM FRUTESCENS fruit extract, CITRUS PARADISI fruit extract, RUSCUS ACULEATUS root extract, EQUISETUM ARVENSE extract, GLYCYRRHIZA GLABRA root extract/ascorbyl methylsilanol pectinate, methylsilanol hydroxyproline aspartate, dimethylsilanol hyaluronate, aminoethylphosphinic acid, propylene glycol, butylene glycol, methylpropanediol, ethanol, water, PEG-<NUM> castor oil, phenoxyethanol and sodium benzoate.

As a further embodiment, the polyol is one or any combination of glycerylglycerin, propylene glycol, <NUM>,<NUM>-butylene glycol, sorbitol, and glycereth-<NUM>, and preferably glycerylglycerin.

As a further embodiment, all the oil comes from natural sources. The oil is any combination of PRUNUS AMYGDALUS DULCIS oil, Canola oil, C15-<NUM> alkanes, SIMMONDSIA CHINENSIS seed oil, sunflower seed oil, soybean oil, squalane, octyldodecanol, mineral oil, dimethylsiloxane and cyclomethicone. The ratio of the oil phase may be <NUM>-<NUM>%, particularly <NUM>-<NUM>%.

As a further embodiment, the oil gel includes the following components in parts by weight% parts by weight: <NUM>-<NUM> parts of active ingredient; <NUM>-<NUM> parts of polyol; <NUM>-<NUM> part of SODIUM SURFACTIN; <NUM>-<NUM> parts of oil; <NUM>-<NUM> parts of water; and <NUM>-<NUM> part of pigment.

As a further embodiment, the oil gel is prepared by a D-phase emulsification method. The oil gel is obtained by a D-phase emulsification process. With only <NUM>-<NUM>% dosage of emulsifier, up to <NUM>-<NUM>% of the oil can be emulsified, and a clear and transparent oil gel can be prepared. If necessary, an anhydrous formula can also be prepared with an emulsion particle size of <NUM>-<NUM> microns.

As a further embodiment, the oil gel further includes <NUM>-<NUM> part of pigment.

As a further embodiment, the hydrogel includes the following components in parts by weight% parts by weight: <NUM>-<NUM> parts of water, <NUM>-<NUM> parts of butylene glycol, <NUM>-<NUM> parts of refined peptide complex, <NUM>-<NUM> parts of phytosterols complex, <NUM>-<NUM> parts of glycereth-<NUM>, <NUM>-<NUM> part of polyacrylate crosspolymer-<NUM>, <NUM>-<NUM> part of xanthan gum, <NUM>-<NUM> part of preservative complex, <NUM>-<NUM> part of PEG-<NUM> hydrogenated castor oil, and <NUM>-<NUM> part of flavor.

As a further embodiment, the refined peptide complex is a composition of water, polysorbate-20polysorbate <NUM>, carbomer, palmitoyl tetrapeptide-<NUM>, palmitoyl pentapeptide-<NUM>, acetyl hexapeptide-<NUM>, glycerol and <NUM>,<NUM>-hexanediol. The phytosterols complex is a composition of water, propylene glycol and phytosterols. The preservative complex is a combination of phenoxyethanol, methylparaben, ethylparaben and ethylhexylglycerylethylhexylglycerin.

The double-agent essence according to the present application is composed of two transparent essences. The oil gel formula is basically of a natural origin and does not contain fragrance preservatives. The oil gel is prepared by the D-phase process with natural fermented SODIUM SURFACTIN as the emulsifier and the natural origin oil as the main body. The hydrogel is a transparent water-soluble gel made from a water-soluble polymer. When in use, the two transparent gels are mixed in a certain ratio and subjected to secondary emulsification to obtain milky white emulsions with different skin feels.

The change process during use is shown in <FIG>.

That is, when in use, the transparent oil gel and the transparent water-based gel (hydrogel) are pumped to the palm of one hand separately and immediately become a milky white emulsion after being mixed by fingers at room temperature to produce a secondary emulsification, which can bring about an instant magic experience to the customer. Due to the high oil phase content of the transparent oil gel, the customer can obtain different types of products by adjusting different dosages of the two transparent gelatins during use. For example, when oil gel: hydrogel is mixed at <NUM>:<NUM>, a massage essence can be obtained. When oil gel: hydrogel is mixed at <NUM>:<NUM>, moisturizing essence milk can be obtained. When oil gel: hydrogel is mixed in <NUM>:<NUM>, it can be used as a body lotion. When oil gel: hydrogel is mixed in <NUM>:<NUM>, it can be used as a moisturizer. Therefore, the double-agent essence according to the present application can derive a lot of skin care products, which can greatly streamline the cosmetic bag of the beauty lady during a short business trip or travel, or occasionally use it in emergency.

A method for preparing a double-agent essence includes steps of preparing oil gel, steps of preparing hydrogel and mixing the prepared oil gel and hydrogel.

The steps of preparing the oil gel includes:.

The steps of preparing the hydrogel includes: mixing a formula amount of xanthan gum, polyacrylate crosspolymer-<NUM> and water evenly, heating to <NUM> for <NUM>-<NUM> minutes, and then adding a formula amount of refined peptide complex, phytosterols complex and glycereth-<NUM> when the temperature is lowered to <NUM> to obtain a first mixture; then dispersing a formula amount of preservative complex evenly with a formula amount of butylene glycol to obtain a second mixture; dispersing a formula amount of flavor evenly with a formula amount of PEG - <NUM> hydrogenated castor oil to obtain a third mixture; and finally, adding the second mixture and the third mixture to the first mixture in sequence, and mixing evenly to obtain the hydrogel.

As a further embodiment, the steps of preparing the oil gel includes:.

The method for preparing a double-agent essence according to the present application is obviously different in the operation process. First, the emulsifier SODIUM SURFACTIN should be evenly dispersed with polyol. Then the oil phase is slowly added dropwise to the polyol + emulsifier phase while stirring at medium speed, and the consistency of the paste will increase significantly during the stirring process. Finally, if necessary, the refractive index of the oil-water phase can be adjusted with a small amount of water to obtain a clear and transparent gel.

Compared with the traditional oil-in-water formulation process, the D-phase emulsification process is significantly different in operation process.

First, the emulsifier SODIUM SURFACTIN should be evenly dispersed with glycerylglycerin. Then the oil phase is slowly added dropwise to the glycerylglycerin + emulsifier phase while stirring at medium speed, and the consistency of the paste will increase significantly during the stirring process. Finally, if necessary, the refractive index of the oil-water phase can be adjusted with a small amount of water to obtain a clear and transparent gel.

Compared with the traditional oil-in-water formula, the advantages of the D-phase emulsification method are as follows.

The following are specific embodiments of the present application. The raw materials, equipment, and the like used in the following embodiments can be obtained through purchase except for special restrictions.

A double-agent essence includes oil gel and hydrogel. The oil gel and the hydrogel are mixed according to a presetany ratio when in use. The oil gel is prepared from the following components: active ingredients, polyols, SODIUM SURFACTIN, oil and water. The hydrogel is prepared from the following components: water, butylene glycol, refined sepin complex (composition of water, polysorbate-20polysorbate <NUM>, carbomer, palmitoyl tetrapeptide-<NUM>, palmitoyl pentapeptide-<NUM>, acetyl hexapeptide-<NUM>, glycerol and <NUM>,<NUM>-hexanediol), phytosterols complex (composition of water, propylene glycol and phytosterol), glycerol poly Ether-<NUM>, polyacrylate crosspolymer-<NUM>, xanthan gum, preservative complex (composition of phenoxyethanol, methylparaben, ethylparaben and ethylhexylglycerylethylhexylglycerin), PEG-<NUM> hydrogenated Castor oil, and flavor. (The specific formulations of the oil gels of Examples <NUM>-<NUM> are shown in Table <NUM>, and the formulations of the oil gels of Examples <NUM>-<NUM> are consistent with those in Example <NUM>. The specific formulations of the hydrogel of Examples <NUM>-<NUM> are shown in Table <NUM>, and the formulations of the hydrogel of Example <NUM>- <NUM> is shown in Table <NUM>-<NUM>. The total amount of components in the same example is <NUM> parts).

In this application (as in Table <NUM>-<NUM>), the raw material connected by "/" means that the raw material is a composite raw material and is a whole.

A double-agent essence includes oil gel and hydrogel. The oil gel and the hydrogel are mixed according to a presetany ratio during use. (See Table <NUM> for the specific formulation of the oil gel, and Table <NUM> for the specific formulation of the hydrogel. The total amount of components in the same comparative example is <NUM> parts).

The steps of preparing the oil gels of Examples <NUM>-<NUM> and Comparative Examples <NUM>-<NUM> include:.

The preparation process of the oil gel of Comparative Example <NUM> is changed and the oil gel is directly obtained by homogenizing the oil-water phase.

<FIG> are schematic diagrams of the oil gels of Examples <NUM>-<NUM> and Comparative Examples <NUM>-<NUM>, and their formulations and differences in properties are shown in Table <NUM>.

The hydrogels of Example <NUM> and Comparative Examples <NUM>-<NUM> are all prepared according to the formula in Table <NUM>. The preparation process includes:
mixing a formula amount of xanthan gum, polyacrylate crosspolymer-<NUM> and water evenly, heating to <NUM> for <NUM>-<NUM> minutes, and then adding a formula amount of refined peptide complex, phytosterols complex and glycereth-<NUM> when the temperature is lowered to <NUM> to obtain a first mixture; then dispersing a formula amount of preservative complex evenly with a formula amount of butylene glycol to obtain a second mixture; dispersing a formula amount of flavor evenly with a formula amount of PEG -<NUM> hydrogenated castor oil to obtain a third mixture; and finally, adding the second mixture and the third mixture to the first mixture in sequence, and mixing evenly to obtain the hydrogel.

The preparation process of the hydrogel of Example <NUM> includes:.

The hydrogel of Example <NUM> is a light yellow transparent flowing gelatin, with pH = <NUM>, viscosity = 5416cps (<NUM>#, 5rpm), stable in heat resistance (<NUM> for one month), and stable in cold resistance (-<NUM> for one month).

The hydrogel of Example <NUM> can play a very good anti-allergic effect. The specific principle is as follows.

IMMORTAL WA II: It is rich in active ingredients such as carotenoids, flavonoids and polysaccharides (iso-glucan, β-glucan and α-glucan), which can promote the expression of AQP-<NUM> and hyaluronic acid synthase, and has the effects of moisturizing, anti-oxidation and promoting wound healing; in addition, the β-glucan contained therein also has the effects of improving skin immunity and anti-pollution.

PONCIRUS EXTRACT: It is extracted from the fruit of Fructus Aurantii, and contains more than 5000ppm of Citrus glycosidesponcirin. It has anti-allergic and anti-inflammatory effects. It is more effective when combined with Portulaca oleracea and can protect cells against UVB-induced cell death.

MADECASSOSIDE: It is extracted from wild Centella asiatica grown in Madagascar and rich in high-purity madecassoside, which can soothe the skin, rebuild extracellular matrix components, anti-inflammatory, regulate and protect the epidermis. In vivo experiments can relieve itching, anti-erythema and improve skin scaling, soothe sensitive skin, atopic dermatitis and psoriasis skin. It is suitable for care products for atopic dermatitis, sensitive and mature skin.

The hydrogel of Example <NUM> is a transparent flowing liquid, with pH = <NUM>, stable in heat resistance (<NUM> for one month), and stable in cold resistance (-<NUM> for one month).

The hydrogel of Example <NUM> can play a good role in whitening and removing spots. The specific principle is as follows.

SEPIWHITE MSH: It is an antagonist of the melanocyte-stimulating hormone α-MSH in the process of melanin synthesis. It acts on multiple biochemical reaction stages of melanin formed by α-MSH, thereby comprehensively and effectively inhibiting the production of melanin, and the effect is more obvious and lasting. It can be used in various formulas to make skin clear. BIO-SODIUM HYALURONATE POWDER (MMW) : It is high-purity, high-quality sodium hyaluronate powder with a molecular weight of <NUM> to <NUM> megadaltons, which can form a viscoelastic, colorless, transparent and non-occlusive film on the skin, thereby having the effect of moisturizing and increasing skin elasticity. MAGNOLIA EXTRACT: Because of its elegant appearance, it was once known as the "Heaven Flower" in Korea. It can inhibit the auto-oxidation of dopa, remove free radicals, and can inhibit the pigmentation caused by inflammation or UV irradiation, and has a significant improvement effect on chloasma.

The hydrogel of Example <NUM> is a light yellow transparent flowing gelatin.

The hydrogel of Example <NUM> can play a good role in anti-glycation and anti-free radicals. The specific principle is as follows.

ALISTIN: It is a multi-effect anti-aging product, innovative in anti-aging and anti-oxidation. The accumulation of oxidation will cause the skin structure to collapse, lose its elasticity, and have wrinkles. ALISTINAlitin not only removes free radicals, but also restores the peroxidized cell membranes, prevents the diffusion of oxidation reactions, and achieves oxidative repair, which neither VE nor VC can do. Glycation will cause protein cross-linking, wrinkles, dull and yellow skin. ALISTINAlitin can not only prevent glycation, but also reverse protein glycation by competing with glycated protein. It is recommended for products for the treatment of aging skin or sun protection and post-sun repair, detoxification and resistance to pigmentation caused by aging. It is also a preferred raw material for improving efficacy in products such as whitening, anti-spot, and anti-hair loss.

SETILINE: It is small molecule galactomannan extracted from the outer skin of TRIGONELLA FOENUM-GRAECUM seeds using biotechnology, which can prevent the glycation of collagen and integrin in the dermis, promote the differentiation of epidermal keratinocytes, and increase the thickness of the epidermis, thereby having functions of anti-glycation, anti-aging, anti-wrinkle and improving skin barrier and suitable for anti-wrinkle, anti-aging, firming regeneration and moisturizing products.

BPN-renovarin powder: It is a powerful antioxidant and anti-protein glycation agent that can efficiently capture free radicals in the human body and inhibit the glycosylation and cross-linking reaction of skin proteins, slow down skin aging, and improve skin dullness.

The preparation process of the hydrogel of Example <NUM> includes:
dispersing phase A evenly, and then adding phases B, C and D and stirring evenly.

The hydrogel of Example <NUM> is a yellow liquid, with PH = <NUM> (<NUM>% aqueous solution), viscosity = 1485cps (<NUM># <NUM>'), stable in heat resistance (<NUM> for one month), and state in cold resistance (-<NUM> for one month).

The hydrogel of Example <NUM> can play a very good anti-blue light effect, and the specific principle is as follows.

Cumulative sample N = <NUM> (sample amount to achieve T test).

Test object: to test the moisture retention of the hydrogel alone used in the double-agent essence of Example <NUM> of the present application and the moisture retention of using different ratios of oil gel to verify that the oil gel can improve the moisture retention of the hydrogel.

Test method: <NUM> volunteers between the ages of <NUM>-<NUM> applied <NUM>. 04µL of samples A, B, and C on the inside of one arm in a single application, and subjected to skin moisture content measurement with CK (Derma-Expert MC760) before applying and <NUM> and <NUM> after applying.

A blank control group is set up to test the influence of the external environment on the moisture retention test.

<NUM> VS blank; <NUM> VS <NUM>; <NUM> VS blank.

Claim 1:
A double-agent essence, comprising oil gel and hydrogel, wherein the oil gel and the hydrogel are mixed according to any ratio during use; and the oil gel comprises the following components in% parts by weight: <NUM>-<NUM> parts of active ingredient; <NUM>-<NUM> parts of polyol comprising glycerin; <NUM>-<NUM> parts of SODIUM SURFACTIN; <NUM>-<NUM> parts of oil; and <NUM>-<NUM> parts of water, and wherein the oil gel is prepared by a D-phase emulsification method, and wherein the oil is any combination of PRUNUS AMYGDALUS DULCIS oil, Canola oil, Cl5-<NUM> alkanes, SIMMONDSIA CHINENSIS seed oil, sunflower seed oil, soybean oil, squalane, octyldodecanol, mineral oil, dimethylsiloxane and cyclomethicone.