Patent Description:
A number of well-known therapies are currently practiced in which a targeted cellular blood component (e.g., red blood cells, white blood cells, and platelets) is separated from whole blood and stored for later infusion to a patient. The targeted cell product (e.g., red blood cells, white blood cells, or platelets) may be in a suspension that includes plasma and/or some other supernatant. As such, it is sometimes desirable to "wash" the cellular suspension (typically with a physiologic buffer) to remove the plasma/supernatant, as well as any non-target cellular material, prior to reinfusion. Systems and methods for cell washing are exemplified by <CIT>, <CIT>, and <CIT>, and <CIT>. Each of these published applications discloses cell washing methods utilizing a disposable fluid circuit including a spinning membrane separator and a reusable processing machine. A thawing system for biological substances provided in bags is described in <CIT>. <CIT> discloses a support structure for a mixing bag, wherein the support structure comprises hooks, clamps and a pivotable clamping member.

Fluid processing systems for washing these cellular suspensions may require simultaneous mixing and cooling or heating, various measurements or other manipulation of cell products, which typically are housed in a disposable container, such as a bag. The disposable containers and/or bags may come in different sizes and designs depending on the source, cell type, and user's processes. There may be a wide variety container or bag features to be accommodated, such as: bag size and shape; bag material and texture; retaining holes or slots size, shape or location; material, size or location of tubing extending from the container or bag; and port types, material, size or location. No matter the variation, the wide variety of containers and/or bags need to be retained on a given system while being mixed and/or cooled or heated, or subject to measurements or other manipulation.

It may be desirable for the bag, while full or being filled with fluid, to be disposed on a table and mixed by movement, such as by rocking, orbital or vibratory movement. For example, rocking may provide oscillatory tilting, such as, up to approximately <NUM> degrees beyond horizontal in both directions. Thus, the constantly changing magnitude and direction of the forces associated with the bag to provide mixing may create sloshing, with a tendency for the bag to remove itself from the table. During fluid processing, liquid may be removed or added to the bag, also changing its shape. The bag may start empty and flat and become rounded, with the edges or seams lifting from the surface of the table during processing. If the table is configured to move, such as by rocking, orbital or vibratory motion, it is important to try to secure or retain the bag to prevent sliding, rolling or flipping and/or to maintain close contact with a cooling or heating element, or other measurement or cell manipulation equipment. It is therefore desirable to provide a retaining table which can adequately hold in place multiple bag types and secure the bags during mixing, cooling or heating, or measurements or alternative manipulation.

Disposable kits for fluid processing may include a variety of disposable containers or bags, which typically are flexible, but may be semi-rigid. During fluid processing that includes positioning of a disposable container or bag on a retaining table that may be configured to move, the changing shape of the container during processing tends to require that only one edge of the container may be secured to the table. This may be necessary to avoid restraining the bag so much that it is not able to be filled and/or mixed.

According to the invention, a retaining table as defined in the appended claims is provided.

The present disclosure provides example embodiments having advantageous retaining structures to retain a container on a retaining table during fluid processing that may include movement of the table, such as for mixing of fluid in the container. The retaining structures permit use of containers specifically designed for use with a particular fluid processing system, but also accommodate nonstandard or customer defined containers, which may vary in design and construction. The retaining structures also provide for simple, intuitive and convenient use that permits a single user to quickly install and remove different containers from the retaining table. The structures also conveniently accommodate containers having various locations of ports and tubes extending therefrom. The retaining structures also recognize that, while a disposable container may be secured along only one edge, it is preferable that the edge having a tubing for drainage of the container will be the opposed edge, which is permitted to float or move while the container changes shape during filling or draining.

In a first aspect, a retaining table for use with a fluid processing system comprises a plate having a generally flat top surface with opposed first and second ends and opposed first and second lateral edges for supporting a disposable container, a first retaining structure connected to the plate along the first end, and a second retaining structure connected to the plate along the second end.

In a second aspect, a retaining table for use with a fluid processing system comprises a plate having a generally flat top surface with opposed first and second ends and opposed first and second lateral edges for supporting a disposable container, a door connected to the plate by at least one hinge along the first lateral edge and being movable between open and closed positions, and a latch along the opposed second lateral edge releasably retains the door in the closed position, and further comprising openings at the first and second ends of the plate or door configured for pass through of components extending from the disposable container.

In accordance with additional aspects, the table may be configured for movement and/or may include a temperature adjusting element, measurement or other manipulation apparatus. At least one retaining structure may be connected to the plate along at least one of the first and second lateral edges. Also, the first retaining structure may be adjustably connected to the plate to permit securing and centering of containers of varying length.

The novel and inventive structures disclosed herein provide for unique advantages in retaining disposable containers on a table used in fluid processing and may be used in various configurations to provide desired features for end users.

A more detailed description of the systems in accordance with the present disclosure is set forth herein. It should be understood that the description below of specific devices is intended to be exemplary, and not exhaustive of all possible variations or applications. Thus, the scope of the disclosure is not intended to be limiting and should be understood to encompass variations or embodiments that would occur to persons of ordinary skill.

Turning first to <FIG>, an embodiment of a system <NUM> for processing fluids, such as cell suspensions (e.g., cell washing), is illustrated. The system <NUM> includes a disposable fluid circuit (also referred to as a set or kit) <NUM> and a reusable processing machine or reusable hardware <NUM>.

As seen in <FIG>, the disposable fluid circuit <NUM> is connectable to a source container <NUM> of fluid, in particular biological fluid. The disposable fluid circuit <NUM> includes a spinning membrane separator <NUM> that is used to process the fluid received from the source container <NUM>, and to direct a portion of that fluid into one of more product containers <NUM>. For example, the containers <NUM> may be in the form of flexible bags according to the illustrated embodiment. The flow of fluid from the source container <NUM>, through the spinning membrane separator <NUM>, and to the one or more product containers <NUM> is achieved through the use of first and second syringes <NUM>, <NUM>, which are in fluid communication with the source container <NUM>, the spinning membrane separator (or spinning membrane for short) <NUM>, and the one or more product containers <NUM>. The syringes <NUM>, <NUM> also may be in fluid communication with a number of other containers <NUM>, <NUM>, <NUM>, <NUM>.

The flow of fluid between the containers <NUM>, <NUM>, <NUM>, <NUM>, <NUM>, and <NUM>, the spinning membrane <NUM>, and the syringes <NUM>, <NUM> is controlled using a flow control cassette <NUM>, which may be connected to each of the foregoing by tubing, or lines. In addition, the cassette <NUM> may include internal flow paths that are defined in part by a plurality of separate channels or passages, which in turn may be contained within and may be defined by the structure (e.g., housing) of the cassette <NUM>. The channels may be connected at a plurality of selectable junctions, which may control the flow of fluid from one channel to another. These selectable junctions also may be referred to as valves, valve stations, or clamps, because the selectable junctions provide controlled access between the channels. The cassette <NUM> also may include sensor stations, by which sensors may be associated with the flow paths within the cassette <NUM> to determine characteristics of the flow therein, such as pressure, presence of air and/or fluid, or optical properties. Preferably, the length of each of the lines and channels is kept as short as possible to further minimize the internal volume of the fluid circuit <NUM>.

The housing of the spinning membrane <NUM> and the syringes <NUM>, <NUM> may be integrally formed as part of (i.e., as one piece with) the cassette <NUM>, so as to further reduce the tubing volume associated with the kit <NUM>. According to other embodiments, the spinning membrane <NUM> and/or the syringes <NUM>, <NUM> may be attached to the remainder of the fluid circuit <NUM> at the time of use, as may be the case with one or more of the containers <NUM>, <NUM>, <NUM>, <NUM>, <NUM>, <NUM>. One or more of the containers <NUM>, <NUM>, <NUM>, <NUM>, <NUM> and <NUM> may be replaced with each use. The container <NUM> may, for example, be the final product bag (particularly where it is desired to collect as much final product as possible instead of collecting to a target weight).

As seen in <FIG>, the reusable hardware <NUM> includes a drive <NUM> for the spinning membrane separator <NUM>, a syringe pump <NUM>, <NUM> for each respective syringe <NUM>, <NUM>, and a control cassette interface <NUM> that is associated with the flow control cassette <NUM> when the fluid circuit <NUM> is disposed on the hardware <NUM> (e.g., is mounted on the hardware <NUM>). The cassette interface <NUM> includes actuators and sensors that are associated with the clamps and sensor stations of the flow control cassette <NUM> and are configured to operate the clamps or sense characteristics of the fluid, respectively.

The reusable hardware <NUM> also includes a controller (not shown) that is configured to control operation of the system <NUM>. The controller may include a microprocessor (which, in fact may include multiple physical and/or virtual processors) and one or more electrical circuits and memories. The instructions by which the microprocessor is programmed may be stored on the one or more memories associated with the microprocessor. The memory/memories may include one or more tangible non-transitory computer readable memories, having computer executable instructions stored thereon, which when executed by the microprocessor, may cause the microprocessor to carry out one or more actions as described herein.

The controller may be coupled (i.e., directly or indirectly connected) to the equipment of the reusable hardware <NUM>, such as the spinning membrane drive <NUM>, the first syringe pump <NUM>, the second syringe pump <NUM>, and the cassette interface <NUM>. The controller may operate each of these devices, each of which may be an assembly of other devices or equipment, to cause the fluid to flow through the fluid circuit <NUM> associated with the hardware <NUM>, for example to cause fluid to flow from the source container <NUM>, through the spinning membrane <NUM>, and eventually into the product container(s) <NUM>. The controller may be programmed to perform other actions as well, such as to test the fluid circuit <NUM>, to prime the fluid circuit <NUM>, to rinse parts of the disposable fluid circuit <NUM> after the wash has been performed, to add other components to the cell-containing fluid before that fluid is distributed to the product container(s) <NUM>, and to distribute the cell-containing fluid into the product container(s) <NUM>.

As illustrated, the embodiment of the system <NUM> includes a retaining table <NUM> on which the container <NUM> is disposed. The table <NUM> may be configured to be dynamic, such as to move, by being mounted on a motor-drive shaft <NUM> that permits the retaining table <NUM> to oscillate about an axis of rotation <NUM>. The controller may control the table <NUM> (via a motor connected to the motor-drive shaft <NUM>) to cause the retaining table <NUM> to rock or oscillate to agitate and mix the contents of the container <NUM> disposed on the table <NUM>. It will be appreciated that oscillatory movement of the table may be provided by alternative drive means, or the table may be equipped to move in a different manner, such as via orbital or vibratory movement. While the table is shown directly connected to the fluid processing equipment, it will be appreciated that the retaining table may embody a standalone apparatus and may have a suitable drive system associated therewith.

The retaining table <NUM> also may include a temperature adjusting element for cooling or heating, which permits the material in the container <NUM> to be maintained at a particular temperature. Agitation and cooling may be important to quickly distribute and slow any chemical reaction in the contents of the container <NUM>. Agitation also may force convection, removing temperature gradients within the contents and fully integrating the contents of the container <NUM>. It will be appreciated that the table additionally or alternatively may include other apparatus along the top surface, such as measurement or other equipment used for diagnostic or orther cellular manipulation purposes, wherein it is desirable to maintain close contact with the container during movement of the table.

According to the illustrated embodiment, the contents of the container <NUM> may be filled into one or more product containers <NUM> that are attached to the circuit <NUM>. The system <NUM> may include a scale <NUM> for weighing the contents of the container(s) <NUM>.

The system <NUM> may include other equipment as part of the reusable hardware <NUM>, in addition to the equipment already discussed. For example, the system <NUM> may include a display <NUM> with touch screen <NUM> to permit information to be entered into the system, including information regarding the protocol of the procedure to be carried out by the system <NUM>. The display <NUM> may be an electronic display, for example, with the touch screen <NUM> mounted thereon. Other input devices may be included, such as a pointer (e.g., mouse) and keyboard or keypad. Also, as illustrated in <FIG>, an input device in the form of a barcode reader <NUM> may be attached to the system <NUM> to permit information to be inputted into the system <NUM> (and the controller) by scanning or reading a barcode, such as may be applied to the fluid circuit <NUM> or to one or more of the containers <NUM>, <NUM>, <NUM>, <NUM>, <NUM>, <NUM>. Other output devices also may be included, such as one or more lights (e.g., light emitting diodes or bulbs) <NUM>, which may be used to signal alerts, events or machine states to the operator.

Further details as to the system <NUM> and its operation may be found in<CIT>.

The above-described system <NUM> may require disposable containers <NUM> to be mixed and temperature adjusted or subject to measurements or other manipulation while on the retaining table <NUM>. The container <NUM> ideally should be firmly secured, visible, and accessible. The present disclosure provides retaining means that advantageously center a disposable container on the surface of a table. The disposable containers <NUM> may be provided from a variety of sources, and the retaining structures disclosed herein are intuitive to use and adapt quickly and conveniently to a variety of container designs with possible aforementioned variations, such as in bag size, material, texture, hole or slot shapes, sizes and locations, and port or tubes connected thereto. A disposable container likely will include at least one or more tubes for draining and/or filling. During such draining and/or filling, the shape of the container also may change, which in turn may change the magnitude and direction of the load generated during oscillation. The tables and retaining structures disclosed herein therefore are highly advantageous by being adaptable and able to accommodate a large selection or variety of container or bag designs and structures.

The table <NUM> includes a plate having a generally flat top surface and includes at least one structure thereon for retaining a disposable container, and as such, may be referred to as a retaining table. Preferably, the plate includes structures, or retaining means, along each of the four sides for retaining a container or bag. However, it will be appreciated that it is within the scope of the present disclosure to have retaining structures along fewer than all of the sides of the plate, such as one, two or three structures along selected respective sides of the plate. It also will be appreciated that "sides" of the plate is a relative term in that the plate may not have straight or perpendicular edges. Moreover, the term "plate" will be understood herein to refer to a structure that provides a top of a table, whether it be a separately formed and connected component or an integrally formed portion at the top of the table.

Although specifically designated embodiments are disclosed, it is within the contemplation of the inventors and the scope of the present disclosure to combine elements, retaining structures or features from different embodiments herein. Also, similar or identical elements are numbered similarly throughout the different embodiments in the description and drawings.

<FIG> illustrate an exemplary first embodiment of a retaining table <NUM> for use with a fluid processing system. The table <NUM> includes a plate <NUM>. It will be appreciated that this is an example in which the plate refers to an upper structural element of the table, wherein the plate <NUM> has a generally flat top surface and has opposed first and second ends 125a, 125b, and opposed first and second lateral edges 127a, 127b for supporting a disposable container or bag, such as the container <NUM> of <FIG>. In this example, the table is configured for end-to-end oscillatory movement. The lateral edges are perpendicular to an axis of rotation through a drive shaft <NUM> or drive shaft coupling, which may be used to oscillate the retaining table <NUM>, consistent with the axis of rotation <NUM> and drive shaft <NUM> of <FIG>. As previously noted, alternative means of movement may be provided.

As shown in <FIG>, the plate may be generally rectangular in shape, however, it is within the scope of the current disclosure for the plate to be of alternative shape, such as for example a square, an oval or a shape having a combination of straight and curved edges. In this example, the first end 125a may be curved, as depicted in <FIG>. However, it is within the scope of the disclosure for the first end 125a to be straight like the second end 125b is depicted. Similarly, second end 125b and lateral edges 127a and 127b may be slightly curved, although they are straight in the example shown in <FIG>.

The embodiment of <FIG> optionally includes four retaining structures to keep a disposable container on the retaining table <NUM>, which are disposed along the ends and lateral edges of the plate <NUM>, respectively. For example, a first retaining structure <NUM> is connected to the plate <NUM> along the first end 125a. In this example, the first retaining structure <NUM> is configured as a clip. A second retaining structure <NUM> is connected to the plate <NUM> along the second end 125b. The second retaining structure <NUM> for securing the container to the table <NUM> is configured as a bar. The bar <NUM> has a first end connected to the plate <NUM> and a second end spaced above and parallel to or angled away from the plate <NUM>. At least a central portion of the bar <NUM> is spaced above the plate <NUM>. The bar <NUM> serves as a second retaining structure by permitting a portion of a container or tubing extending from a container to extend under the bar <NUM> and outward from the table <NUM>.

The retaining table <NUM> optionally may include at least one retaining structure connected to the plate <NUM> along at least one of the first and second lateral edges 127a, 127b. The retaining structure may be, for example, a barrier extending upward from the plate, such as the barriers <NUM>, <NUM> along respective lateral edges 127a, 127b. The clip <NUM>, bar <NUM> and barriers <NUM>, <NUM>, or other optional retaining structures, may be connected to the plate by any suitable means relative to the particular structures, such as via mechanical fasteners, adhesive bonding, welding, integral forming or the like.

The retaining table <NUM> may be configured for movement and referred to as a dynamic table or as a table providing a plate having a dynamic surface. For example, the table <NUM> may have an axis of rotation that is perpendicular to the lateral edges 127a, 127b of the plate <NUM>, and be configured to be connected to a drive shaft <NUM>, consistent with the axis of rotation <NUM> and drive shaft <NUM> shown in <FIG>. A portion of the motor drive shaft <NUM> (which may be a coupling) also is shown in <FIG> and may for example impart oscillation. It will be appreciated that the dynamic aspect may be provided by an alternative drive system, or by alternative motion, such as orbital or vibratory, which may be provided by suitable drive systems.

The plate <NUM> optionally may include a temperature adjusting element for cooling and/or heating the disposable container, or alternative apparatus such as for measurements or alternative manipulation of the fluid within the container. In this example, a temperature adjusting element <NUM> is configured as a plate fastened to and disposed on the top surface of the plate <NUM>. It will be appreciated that the temperature adjusting element or other equipment may be connected to the plate via mechanical fasteners, adhesive bonding or the like, or may be integrally formed as part of the upper surface of the plate and/or table. In the example embodiments, the plate, table, and retaining structures may be at least partially formed of one or more metallic, plastic or alternative substantially rigid materials.

The retaining table <NUM> of this example includes the clip <NUM> along the first end 125a, as a first retaining structure for a disposable container. However, other structures may be used for this purpose, consistent with this disclosure, such as a post, a pivot-locking mechanism, a snap fit structure, a cam device, or other suitable structure. Additional details of the clip <NUM> and alternative first retaining structures in the form of clips will be discussed with respect to examples shown in <FIG>, followed by discussion of other first retaining structures, second retaining structures, and as additional retaining structures that may be use along the lateral edges.

The alternative clips of <FIG> may be utilized in the first embodiment of <FIG>. Any of the different clips may be used as part of a retaining table assembly in place of clip <NUM> and with a retaining structure at the second end 125b and optionally with retaining structures, such as in the form of barriers along the lateral edges 127a, 127b of the plate <NUM>. In each clip embodiment in <FIG>, a mobile (movable) jaw is pivotally secured to a base that is connected to the plate <NUM>.

Each clip may have at least one protrusion on at least one of the mobile jaw and/or the base. In addition, the mating surface of the other of the at least one of the mobile jaw and base may have at least one recess sized to receive the at least one protrusion. Although in each embodiment different features are altered, such as the handle, and placement or shape of the protrusion, the features are interchangeable among the different clips and may be combined to provide additional embodiments consistent with the present disclosure, although not specifically shown. For example, a clip may include a compact or exposed handle and a protrusion and recess may be alternatively located on the mobile jaw and stationary base. The protrusions and recesses also may vary in number and shape. There may be a single or multiple protrusions and recesses. The protrusion(s) and recess(es) may be circular, pentagonal, trapezoidal, triangular, or any other suitable shape and complementary to each other. The material and texture of the protrusion, engageable surfaces of base and/or movable jaw also may be selected to improve gripping, such as by comprising a compliant material.

<FIG> illustrates a preferred first example clip <NUM>, which is consistent with clip <NUM> but will be described in further detail. The clip <NUM> includes a mobile jaw <NUM> and a base <NUM>, which is stationary and connected to plate <NUM>. The base may be connected to the plate by any suitable means, such as via mechanical fasteners, adhesive bonding, welding, integral forming or the like. The mobile jaw <NUM> is pivotally connected to the base <NUM> by a pivot pin <NUM>. The mobile jaw <NUM> also is biased to a closed position by a biasing element <NUM> in the form of a torsion spring, although it will be appreciated that a biasing element of an alternative configuration may be used. The mobile jaw <NUM> has a handle portion <NUM> that is compact and without any extending members. This handle configuration avoids any type of tangling between tubes extending from a disposable container and the clip <NUM>. The handle portion <NUM> is pressed toward the base <NUM> to pivot the mobile jaw <NUM> to an open position for loading or unloading a container.

A protrusion <NUM> extends from the mobile jaw <NUM> and is received in a recess <NUM> of the stationary base <NUM> when the movable jaw <NUM> is in a closed position. The recess <NUM> is shaped and sized large enough to provide clearance to release the protrusion <NUM> when pivoting the mobile jaw <NUM> to an open position for removal of a bag or when moving a bag into position to be retained by the clip <NUM>. In this example, the protrusion <NUM> and recess <NUM> may be at least partially pentagonal in shape and may include a triangular outside portion, or may be of other suitable shapes.

<FIG> illustrates a second example of a first retaining structure for retaining a container, in the form of an alternative clip <NUM>, which may be connected to a plate, consistent with one of the ways previously described. The clip <NUM> of <FIG> differs primarily from that of the clip <NUM> of <FIG> in that the clip <NUM> has a mobile jaw <NUM> that includes an exposed handle portion <NUM>, which extends outward. The exposed handle portion <NUM> may be of any shape and size and may have a generally rectangular cross section, as shown in <FIG>. Similarly to the previous example, the mobile jaw <NUM> is pivotally connected to a base <NUM> by a pivot pin <NUM>. The mobile jaw <NUM> also is biased to a closed position by a biasing element <NUM>, such as a torsion spring, although other biasing elements may be used.

A protrusion <NUM> extends from the mobile jaw <NUM> and is received in a recess <NUM> of the stationary base <NUM> when the mobile jaw <NUM> is in a closed position. The recess <NUM> is shaped and sized large enough to provide clearance to release the protrusion <NUM> when pivoting the mobile jaw <NUM> to an open position. The protrusion <NUM> and recess <NUM> may be at least partially pentagonal in shape and may include a triangular outside portion or other configuration. Optionally, the recess <NUM> may be configured to releasably secure the protrusion <NUM> when the mobile jaw <NUM> is in the closed position.

<FIG> illustrates a third example of a first retaining structure for retaining a container, in the form of another alternative clip <NUM>, which may be connected to a plate, consistent with one of the ways previously described. The clip <NUM> of <FIG> has a similar configuration to the clip <NUM> of <FIG> having an exposed handle portion <NUM> on a mobile jaw <NUM> that is pivotally connected to a base <NUM> by a pivot pin <NUM> and biased to a closed position by a biasing element <NUM>. However, the clip <NUM> includes a different protrusion and complementary recess configuration. A protrusion <NUM> extends from a stationary base <NUM> of clip <NUM>. A recess <NUM> is formed in the opposed surface of the mobile jaw <NUM>. The recess <NUM> does not require as much space in this arrangement, wherein the protrusion <NUM> is configured as a tooth that readily fits within the recess <NUM> and has clearance when pivoting the mobile jaw to an open position. The protrusion <NUM> and recess <NUM> may be at least partially pentagonal in shape and may include a triangular outside portion or be of other suitable complementary shapes.

<FIG> illustrates a fourth example of a first retaining structure for retaining a container, in the form of another alternative clip <NUM>, which may be connected to a plate, consistent with one of the ways previously described. The clip <NUM> includes an exposed handle portion <NUM> on a mobile jaw <NUM> that is pivotally connected to a base <NUM> by a pivot pin <NUM> and biased to a closed position by a biasing element <NUM>. However, the clip <NUM> includes a different protrusion and complementary recess configuration that optionally may be used on the clip <NUM> having a compact handle portion <NUM>.

The clip <NUM> includes multiple protrusions <NUM>, <NUM>, and <NUM>. Protrusions <NUM> and <NUM> extend from the mobile jaw <NUM> toward the base <NUM>, and protrusion <NUM> extends from the stationary base <NUM> toward the mobile jaw <NUM>. Alternatively, protrusions <NUM> and <NUM> may extend from the stationary base <NUM> and protrusion <NUM> may extend from the mobile jaw <NUM>. In yet another alternate embodiment, protrusions <NUM>, <NUM>, and <NUM> may extend from the mobile jaw <NUM> only or from the stationary base <NUM> only.

As with other embodiments, whichever portion of the clip include a protrusion, the other or opposed portion may have complementary recess. It will be appreciated, however, that the portion of the clip without a protrusion alternatively may be flat, without a complementary recess. Also, while three protrusions are shown in the example of <FIG>, two or more than three protrusions alternatively may be used. Preferably, the protrusions will be configured to alternate between extending from the mobile jaw and from the stationary base. The protrusions also may be on only one of the mobile jaw or base. The protrusions of the example shown in <FIG> are shown as having a generally rectangular configuration but may be pentagonal, ciruclar, triangular or alternatively shaped.

<FIG> illustrates a fifth clip embodiment <NUM> as a first retaining structure. The clip <NUM> is similar to clip <NUM> of <FIG> but includes a circular shaped protrusion <NUM> extending from a mobile jaw <NUM>, which is received by a complementary shaped recess <NUM> in a base <NUM>. The base <NUM> may be connected to a plate in a stationary position, consistent with one of the ways previously described. The clip <NUM> includes an exposed handle portion <NUM> on the mobile jaw <NUM> that is pivotally connected to the base <NUM> by a pivot pin <NUM> and biased to a closed position by a biasing element <NUM>. The circular shaped protrusion <NUM> may be constructed of a compliant material which enables the protrusion <NUM> to at least slightly deform and increase the contact area with a retained bag. As noted with respect to the previous example clips, the protrusion alternatively may be on the base, with the recess on the mobile jaw.

The clip mating faces (protrusion and recess) can be varied in additional ways not specifically shown. The mating faces of the clip may vary not only in shape, structure, and size, but also in material. In certain embodiments, including those with a protrusion or recess, the mating faces for features may be composed of the same material as the rest of the clip, including plastics or metals. Additionally, the mating faces may be composed of a compliant material, such as rubber or the like. In such embodiments, due to the more compliant material, the recess and/or protrusion may not be needed. For instance, the material may be compliant enough that the protrusion interacts directly with the base and does not require a recess. Both mating faces may be constructed of a compliant material, which may remove the need for the protrusion and recess. The clip also may be modified by changing to a different biasing member structure, by changing the distance between the pivot axis and the end of the handle portion and/or the distance between the pivot axis and the gripping end of the mobile jaw.

As noted previously, the plate <NUM> optionally may include a second retaining structure along the second end 125b, which may be a bar <NUM>. <FIG> more clearly show the bar <NUM>, having one end angled away from the plate <NUM>. For example, the bar may have first and second ends <NUM>, <NUM>, respectively. The first end <NUM> may be secured to the plate <NUM> near the lateral edge 127b and the bar <NUM> may be configured to be spaced from and extend laterally across at least a portion of the plate <NUM>, with the second end <NUM> extending further away from the plate <NUM> at an angle, near the lateral edge 127a, but not secured to the plate. In one embodiment, the bar may be adjusted to the size of the bag with a hinge or other adjustable mechanism at the first end, where it is secured to the plate. A bar having a second end angled away from the plate is preferred for retaining a container directly or via retention of tubing extending from the container along the second end of the plate. However, it will be appreciated that other second retaining structures may be used.

When used in combination with a clip at the first end of the plate, it is important that the second retaining structure that holds the second end of the disposable container does not fix the container to the plate. The second end typically will need to accommodate a portion of the disposable container having at least one tube extending therefrom. The particular structure of one or more tubes that extend from a disposable container may vary significantly and the angled end of the bar may accommodate tubes of various sizes and constructions to slide into the space between the bar <NUM> and the plate. The bar <NUM> also may serve as a barrier and tend to hold down a container or block it from sliding, while allowing a tube to pass under the bar.

The retaining table <NUM> of <FIG> also optionally includes at least one barrier as a retaining structure along each lateral edge 127a, 127b and which extends upward from the plate <NUM>. <FIG> illustrates barriers <NUM>, <NUM>, along the respective opposed lateral edges. The example side barriers <NUM>, <NUM> are raised walls extending upward from the plate <NUM>. An inner surface on a section of the barrier wall may extend upward at an angle, while an outer surface of the barrier wall generally may extend upward vertically or also at a slight angle. The angled inner surfaces of the side barriers <NUM>, <NUM> serve as an additional feature to help center the disposable container when placing it on the plate <NUM>, as well as to hold the container in place and/or continue to bias the container toward a centered position disposed over the temperature adjusting element <NUM>.

The barriers <NUM>, <NUM> may include a thicker portion <NUM>, <NUM> near the clip <NUM> and first end 125a of the plate <NUM>. The thicker portions <NUM>, <NUM> may act as a barrier at the first end 125a of the table <NUM>. These portions may absorb some of the force from a container that is subjected to rotation during oscillatory mixing and help control such force to avoid inadvertent opening of the clip <NUM>. The barriers <NUM>, <NUM> may be constructed as solid walls integrally formed with the plate or may be separate structures connected to the plate by conventional means of fastening. The side barriers may present solid surfaces, may have openings extending therethrough, or be configured as a bar having at least a portion spaced from and above the plate.

To assist in positioning and approximately centering disposable containers or bags of various lengths and widths over a plate and over a temperature adjusting element, measurement or other manipulation equipment or other apparatus for which location of the container is important, a first retaining structure for fixing the container to the plate at the first end may be adjustable. In this particular example, the adjustment is configured to be in a direction along the longer axis of the retaining table and perpendicular to a rotational axis. <FIG> illustrate a second embodiment of a retaining table of the present disclosure with such an adjustable clip configuration. The first retaining structure is adjustably connected to two barriers along the respective first and second lateral edges of the plate. This embodiment includes a clamp system connected to the first retaining structure and releasably lockable along the two barriers to permit adjustment for preferable centering of different length disposable containers along the dynamic retaining table.

In reference to <FIG>, the example retaining table <NUM> is similar to retaining table <NUM> in that it includes a plate <NUM> having a generally flat upper surface and an optional temperature adjusting element <NUM>. While any of the first retaining structures disclosed herein may be utilized in a length adjustable configuration, this example includes a clip <NUM> as a first retaining structure along a first end 725a. A bar <NUM> provides an optional second retaining structure along a second end 725b. However, at least one further retaining structure in the form of side barriers <NUM>, <NUM> along lateral edges 727a, 727b of the plate <NUM> may be of a different configuration than in the previous embodiment, which permits the location of the clip <NUM> to be adjustable relative to the first end 725a.

The side barriers <NUM>, <NUM> are fixed to the plate <NUM> and include wall portions <NUM>, <NUM>, which are fixedly connected to the plate <NUM>, such as by mechanical fasteners, bonding or by being integrally formed therewith. The side barriers <NUM>, <NUM> also include fixed adjustment portions <NUM>, <NUM>, which include rodshaped portions parallel to and spaced from the top surface of the plate <NUM> having notches 758a, 760a that are open outward, although it will be appreciated that the orientation of the notches will be based on the configuration of the releasable locking mechanism associated therewith. The adjustment portions <NUM>, <NUM> have a first end fixedly connected to the plate <NUM> and a second end fixedly connected to and extending from one of the fixed wall portions <NUM>, <NUM>, respectively, with the fixed connections being by conventional means, such as those previously described.

The clip <NUM> has a base <NUM> and a mobile jaw <NUM>, which is pivotally connected to the base <NUM> via a pivot pin <NUM> and is biased to a closed position by a biasing element (not shown). The base <NUM> of the clip <NUM>, or an alternative first retaining structure, is fixedly connected to a yoke <NUM>. The yoke <NUM> is constructed as a thin, flat bracket that is parallel to and may slide along or be spaced from the top generally flat surface of the plate <NUM>. Also, fixedly connected to the yoke <NUM> is a clamp system <NUM>. The clamp system <NUM> includes clamp devices <NUM>, <NUM> that are slidably and lockingly connected to the respective side barriers <NUM>, <NUM>, at the adjustment portions of <NUM>, <NUM>, along the first and second lateral edges 127a, 127b of the plate <NUM>. The clamp system <NUM> permits the position of the yoke <NUM>, and therefore, the clip <NUM> to be adjusted relative to the first end 725a of the plate <NUM>.

Each clamp device <NUM>, <NUM> includes a base and a latch that engages a respective barrier. The clamp devices <NUM>, <NUM> slidably receive the respective adjustment portions <NUM>, <NUM> and are moveable along the respective lateral edges 727a, 727b of the plate <NUM>. The latch of the clamp devices <NUM>, <NUM> may be in the form of a release mechanism. The release mechanism may be a button, cam latch, thumb screw, or other suitable release mechanism, including the example mechanisms illustrated in <FIG>.

<FIG> shows a portion of the example clamp device <NUM>, which may be utilized in the clamp system <NUM> of the example retaining table <NUM> of <FIG>. The clamping device <NUM> includes a latch <NUM>, which is biased into a locking position in one of the notches 758a of the adjustment portion <NUM>, such as by a spring <NUM>. A release button <NUM> may be pressed to force the latch <NUM> out of the notch 758a while compressing the spring <NUM>. It will be appreciated that the clamp device <NUM> may have a similar structure to that of <NUM>. Upon release of the clamp devices <NUM>, <NUM>, the yoke <NUM> may be moved along the plate <NUM> to adjust the position of the clip <NUM>. When the release buttons are no longer pressed, the latches will be biased into a locking position in selected notches 758a, 760a of the respective adjustment portions <NUM>, <NUM>.

<FIG> illustrate a second embodiment of a clamp system <NUM> that may be substituted for the clamp system <NUM> of <FIG>. The clamp system <NUM> includes clamp devices <NUM>, <NUM> and is shown connected to a yoke <NUM>, which is similar to yoke <NUM>. Each of the clamp devices <NUM>, <NUM> slidably and lockingly receives an adjustment portion, such as the adjustment portion <NUM>, having downward opening notches 858a, as may be seen in <FIG>. The clamp devices <NUM>, <NUM> include a lever 829a, 829b, respectively.

As will be appreciated with respect to the clamp device <NUM> in <FIG>, lifting an end of the lever 829a will cause the oblong shaped body of the lever 829a to pivot about a pin <NUM> and thereby to force a latch <NUM> downward. The latch <NUM> is biased toward an upward position, such as by springs <NUM>. In the upward position, a lower portion <NUM> of the latch <NUM> is received in a downward opening notch 858a of the adjustment portion <NUM>, locking the clamp device <NUM> and preventing movement along the adjustment portion <NUM>. Lifting the lever 829a compresses the springs <NUM>, thereby removing the lower portion <NUM> of the latch <NUM> from the notch 858a in the adjustment portion <NUM>. The lever 829a provides a convenient grip location and may remain in an unlocked position while moving the clamp device <NUM>. It will be appreciated that the latch <NUM> is biased upward toward a locked position by the springs <NUM>, so the lever 829a may be closed without engaging a notch 858a, but the latch <NUM> will automatically engage a notch 858a when the clamp device <NUM> is moved along the adjustment portion <NUM>, such as may occur if the retaining table starts oscillating.

It will be appreciated that the side barriers <NUM>, <NUM> may be alternatively configured relative to those shown in <FIG>. For example, the barrier portions may be larger or smaller with less space between the adjustment portions and the plate. The notches also may be alternatively configured such as by having different shapes or a different number of notches, depending on the configuration of the clamp devices. Alternatively, the adjustment portions of the side barriers may be constructed of a compliant material, such as rubber, the latches may engage and deform the adjustment portions to an extent whereby notches may not be required to attain a locked position.

As noted previously, it will be appreciated that the plate used on a dynamic retaining table may be a separate component connected to the table or may be integrally formed as a top portion of the table, and may be alternatively equipped with different retaining means for holding disposable containers or bags along a first end, whether fixedly attached to or positionally adjustable relative to the plate. <FIG> illustrate a third example embodiment of a retaining table <NUM> without a clip of the prior example embodiments along a first end 925a of a plate <NUM>. The first end 925a of the plate <NUM> may include a first retaining structure having an upstanding portion <NUM> configured as a post or elongated projection having an enlarged head <NUM>. It will be appreciated that the upstanding portion <NUM> may be of any suitable length. The enlarged head <NUM> may be of any length and/or shape that may aid with retaining a disposable container or bag. For example, the enlarged head may be mushroom shaped. This may be particularly advantageous when the disposable containers or bags include an aperture or slot near one end. The retaining table <NUM> may be oscillated via the coupling or drive shaft <NUM>. As noted previously with respect to the examples illustrated herein, the table may be driven by an alternative oscillatory drive, or may be subject to other dynamic movement, such as orbital or vibratory by use of a further alternative drive system.

The table <NUM> also includes a second retaining structure in the form of a bar <NUM> having a portion spaced from the top surface of the plate <NUM> and disposed along a second end 925b of the plate <NUM>. The retaining table <NUM> also optionally may include at least one barrier along lateral edges 927a, 927b. The example table <NUM> is shown with barriers <NUM>, <NUM>, along the respective lateral edges 927a, 927b of the plate <NUM>. The barriers may be similarly or differently shaped relative to the example barriers of the previous embodiments.

<FIG> illustrate two related alternative embodiments for retaining a disposable container on a retaining table used with a processing system. Each figure includes a plate, which would be connected to a dynamic table, as in the previous examples. Also, as in the previous examples, each plate has a generally flat top surface with opposed first and second ends and opposed first and second lateral edges for supporting a disposable container. Although not shown in <FIG>, the plates also may include at least one side barrier of a type as previously described, such as including fixed walls, adjustable bars or the like. However, as with the previous examples, it is not required to have a barrier along either lateral edge.

A fourth embodiment of a retaining table <NUM> is illustrated in <FIG>. A releasable locking system <NUM> of the example in <FIG> is provided as a first retaining structure disposed along a first end 1025a of a plate <NUM>. The locking system <NUM> includes a first stationary block <NUM> and second stationary block <NUM>, which are connected to the plate <NUM>, near respective opposed lateral edges 1027b, 1027a, respectively. A mobile (movable) bar <NUM> is pivotally secured to the first stationary block <NUM>, such as by a hinge <NUM> or other pivoting attachment means at the first end of the mobile bar <NUM>. On the second end near lateral edge 1027a, the mobile bar <NUM> is releasably connected to the plate <NUM> via the second stationary block <NUM>.

A pin <NUM> releasably engages and locks the mobile bar <NUM> in a closed position. The pin <NUM> is movably connected to the stationary block <NUM> that is connected to the plate <NUM>. The bar <NUM> may be released to pivot upward to an open position by pulling the pin <NUM> in a direction away from the mobile bar <NUM>. The pin <NUM> may be perpendicular to the mobile bar <NUM> and engage the mobile bar <NUM> in a way so as to block its pivotal movement upward, such as by engaging a notch or aperture in the mobile bar <NUM>, or in the second stationary block <NUM> at a location above the mobile bar <NUM>. Once locked in place, the locking system <NUM> secures a disposable container, such as container <NUM>, against the generally flat top surface of the plate <NUM>. The pin may be a pull pin and may include a retaining ring, or biasing member. Alternatively, the pin may be a threaded pin, ball detent pin or be of other suitable releasable structure. It will be appreciated that the disposable container <NUM> may include tubing <NUM> and the second end 1025b of the plate <NUM> may utilize a second retaining structure in the form of a bar <NUM> spaced above the top surface of the plate <NUM>, similarly to previous embodiments. The second end of the container and/or the tubing <NUM> may extend beneath the bar <NUM>, thereby contributing to retaining the container <NUM>. Moreover, use of a mobile bar <NUM> at the first end 1025a and bar <NUM> at the second end 1025b may advantageously permit convenient routing of tubing extending from either end of the disposable container <NUM>.

<FIG> include a fifth embodiment of a retaining table <NUM> somewhat similar to that of <FIG>. A first retaining structure is provided by a locking system <NUM> at a first end 1225a of a plate <NUM>. However, in <FIG>, a pin <NUM> is arranged parallel to a mobile bar <NUM>. With the configuration of <FIG>, the pin <NUM> engages and is received by a recess <NUM> in a second end of mobile bar <NUM>, instead of engaging the mobile bar in a perpendicular configuration. On the second end near lateral edge 1227a, the mobile bar <NUM> releasably connects to the second stationary block <NUM>.

Thus, the locking system <NUM> includes a first stationary block <NUM> and second stationary block <NUM>, which are connected to the plate <NUM>, near respective opposed lateral edges 1227b, 1227a, respectively. A mobile (movable) bar <NUM> is pivotally secured to the first stationary block <NUM>, such as by a hinge <NUM> or other pivoting attachment means at the first end of the mobile bar <NUM>.

A pin <NUM> releasably engages and locks the second end of the mobile bar <NUM>. The bar <NUM> may be released by pulling the pin <NUM> in a direction away from the mobile bar <NUM>. The pin <NUM> may be parallel to the mobile bar <NUM> and engage the mobile bar <NUM> by being received in a recess <NUM> in the second end of the mobile bar <NUM>. Once locked in place, the locking system <NUM> secures a disposable container, such as a container <NUM>. The pin may be slidably received in the second stationary block <NUM>, or constructed consistent with the previously described alternative pin constructions. As in the previous examples, it will be appreciated that the disposable container <NUM> may include tubing <NUM> and the second end 1225b of the plate <NUM> may utilize a second retaining structure in the form of a bar <NUM> spaced above the top surface of the plate <NUM>. Use of a mobile bar <NUM> at the first end 1225a and bar <NUM> at the second end 1225b may permit tubing to be conveniently accessed and routed from either end of the disposable container <NUM>.

Depending on the configuration of the mobile bar and the pin in both of the fourth and fifth embodiments, the mobile bar may have notches, holes, and/or a recess for the pin to engage when locking the mobile bar after pivoting it downward to a closed position to retain a disposable container.

<FIG> illustrate a modification to the fifth example embodiment of a retaining table <NUM> shown in <FIG>. The modification includes a cam <NUM> disposed on the bar <NUM> and is configured to engage a container <NUM>. The cam <NUM> may assist in stabilizing and gripping the container <NUM>. The cam <NUM> may be rotatably adjustable relative to the bar. Thus, the cam <NUM> may be connected to the bar <NUM> about the longitudinal axis of the bar and rotated to a position to apply greater or lesser holding force against the plate <NUM>. The cam may be a variety of shapes including, but not limited to, circular/spherical, rectangular/cube or generally cam shaped, and may be configured to be located in one position or movable along the mobile bar <NUM>. The cam also may be constructed of various materials, including potentially of a compliant material to assist in gripping a container. It will be appreciated that a further modification may include having the first retaining structure configured as a rotatable bar, with the cam fixed rotationally relative to the bar, such that the position of the cam relative to the table is adjusted by rotation of the bar. Additionally, the cam may be located on a first retaining structure configured as a fixed bar, such that the cam may be rotated about the bar to permit loading of a container and then engaging the container to retain the container on the plate.

<FIG> illustrate a sixth embodiment of a retaining table <NUM>. Table <NUM> includes a plate <NUM> having a generally flat top surface with opposed first and second ends 1425a, 1425b and opposed first and second lateral edges 1427a, 1427b for supporting a disposable container <NUM>. The retaining table <NUM> also includes a first retaining structure configured to be a locking system <NUM> along a first end 1425a of the plate <NUM> comprising a mobile (movable) bar <NUM> pivotally connected to the plate <NUM> at a first end by a hinge <NUM> and having a locking mechanism at a second end of the bar <NUM> near lateral edge 1427a. The locking mechanism includes a latch <NUM>. The latch <NUM> includes at least one protrusion <NUM> at a second end of the mobile bar <NUM> and an aperture <NUM> through the plate <NUM> configured to releasably receive the at least one protrusion <NUM>. Alternatively, the latch may include an aperture and the plate may have an upward extending protrusion that engages the latch when extending through the aperture. The latch <NUM> also may include a handle <NUM> for convenient grasping and actuation of the latch <NUM>. The locking system <NUM> retains the container <NUM> at the first end 1425a of the plate <NUM>. The table <NUM> also may include a second retaining structure, such as the bar <NUM>, which may be similar to the bar at the second end in the previous examples, as well as additional side barriers, as previously discussed.

<FIG> illustrates a seventh embodiment of a retaining table <NUM>. The table <NUM> has a plate <NUM> having a generally flat top surface with opposed first and second ends 1525a, 1525b and opposed first and second lateral edges 1527a, 1527b for supporting a disposable container <NUM>. The retaining table <NUM> includes a first retaining structure including a band <NUM> along a first end 1525a of the plate <NUM> extending from the first lateral edge 1527a to the second lateral edge 1527b. A second retaining structure is provided along the width of the second end 1525b of the plate <NUM> by a bar <NUM>. This is similar to previous examples, such that the bar <NUM> is connected to the plate <NUM> at a first end and spaced above the plate <NUM> along its length. The table <NUM> optionally also may include retaining structures along the lateral edges 1527a, 1527b, such as the side barriers previously discussed in earlier examples.

<FIG> illustrates a modification to the seventh embodiment of <FIG>. In addition to the first band <NUM>, the retaining table <NUM> optionally also may include a second retaining structure including a second band <NUM> along the second end 1525b of the plate <NUM> extending from the first lateral edge 1527a to the second lateral edge 1527b. This alternative retaining table embodiment also may include retraining structures along the opposed lateral edges, such as the previously discussed side barriers. In addition, the band <NUM> at the second end 1525b may be used in combination with any of the other first retaining structures disclosed herein, whether configured for fixed or adjustable connection to the table.

<FIG> illustrate eighth and ninth example embodiments of retaining tables. The tables include a roller as part of the retaining structures. <FIG> illustrate an eighth embodiment of a retaining table <NUM> including a plate <NUM> having a generally flat top surface with opposed first and second ends 1625a, 1625b and opposed first and second lateral edges 1627a, 1627b for supporting a disposable container <NUM>. The table <NUM> further includes a first retaining structure including a stationary bar <NUM> and a roller <NUM> along the first end 1625a of the plate <NUM>. The roller <NUM> is spaced apart from the stationary bar <NUM>. The roller <NUM> also is pivotally connected to the plate at a first end, such as via a hinge <NUM>, releasably connected to the plate <NUM> at a second end via a locking system <NUM>.

The locking system <NUM> may include a releasable latch <NUM>. The latch may include at least one protrusion extending from a holder at the end of the roller <NUM> and an aperture on the plate <NUM> sized to receive the protrusion, or a protrusion extending from the plate <NUM> and sized to be received by an aperture in a holder at the end of the roller <NUM>. Other latching means may be utilized. The roller <NUM> is used to capture a first end of the container <NUM>. Thus, with the latch <NUM> unlocked and the roller <NUM> pivoted upward to an open position, the first end of a container <NUM> that is disposed on the plate <NUM> may be extended over the stationary bar <NUM>. With the upper end of the container <NUM> extending over the bar <NUM> along the first end 1625a of the plate <NUM>, the roller <NUM> then may be pivoted about its first end to have the second end move downward to engage and squeeze the upper end of the bag between the roller <NUM> and the bar <NUM> and to engage the latch <NUM>. As noted with previous examples, the upper end of the bag may have one or more tubings extending from it, which may extend from the upper end being held by the bar <NUM> and the roller <NUM>. A second retaining structure is provided at the second end 1625b of the plate <NUM> in the form of a bar <NUM>, which is similar to previously described examples, and permits a tubing <NUM> to extend therefrom. Additional retaining structures may be provided along the lateral edges.

<FIG> illustrates the ninth embodiment of a retaining table <NUM>, which also includes a first retaining structure having a stationary bar <NUM> along a first end 1725a of a plate <NUM> and a second retaining structure including a bar <NUM> along a second end 1725b of the plate <NUM>. The table <NUM> also may include further retaining structures in the form of side barriers, as previously discussed with other embodiments.

The retaining table <NUM> in <FIG> includes a roller <NUM> connected to the first end 1725a of the plate <NUM> by springs <NUM>, <NUM>. For example, the springs are shown being connected to the stationary bar <NUM>, but it will be appreciated that the springs may be connected directly to the plate or to other intermediate structures, such as posts or the like. The springs are connected to roller holders that slide relative to the opposed guides <NUM>, <NUM> along the lateral edges 1727a, 1727b of the plate <NUM>. The springs are configured to bias the roller <NUM> toward the second end 1725b of the plate <NUM>. This may assist during filling and/or drainage of the container to tend to keep the fluid toward the second end 1725b of the table <NUM>. As fluid fills the container <NUM> and the container <NUM> expands in a direction away from the top surface of the plate <NUM>, the fluid will tend to push the roller toward the first end 1725a of the plate <NUM>. In a similar manner, as fluid is removed from the container <NUM>, the roller will be biased back toward the second end 1725b of the plate <NUM>. Thus, the roller <NUM> is configured to move up and down along the plate <NUM>, toward and away from the second end 1725b. This may help to avoid retaining air in the container, to keep the fluid located toward one end of the container and to reduce forces that may otherwise be amplified by sloshing during oscillation of a partially filled container.

<FIG> illustrate a tenth embodiment of a retaining table <NUM> for use with a fluid processing system. <FIG> shows the table in a closed position and <FIG> shows the table in an open position. <FIG> shows a cross section of the table <NUM>. The retaining table <NUM> includes a plate <NUM> having a generally flat top surface with opposed first and second ends 1825a, 1825b and opposed first and second lateral edges 1827a, 1827b for supporting a disposable container. The table <NUM> includes a door <NUM> connected to the plate <NUM> by at least one hinge <NUM> along the first lateral edge 1827a and being movable between open and closed positions, and a latch <NUM> to releasably retain the door <NUM> in the closed position disposed along the opposed second lateral edge 1827b. The table <NUM> also includes example openings <NUM> and <NUM> at the first and second ends 1825a, 1825b of the plate <NUM>, respectively, configured for pass through of components extending from the disposable container, such as tubings. However, it will be appreciated that suitable openings to permit pass through of tubings extending from a container may be provided in alternative configurations, such as in the ends of the door.

The door may optionally include a second plate <NUM> connected to the door <NUM> and biased toward the plate <NUM> of the table <NUM> when the door <NUM> is in the closed position. The second plate <NUM> is connected to the door <NUM> by a plurality of springs <NUM>, <NUM>, <NUM>. When the door is in a closed position, the springs cause the second plate <NUM> to be biased toward a container that would be disposed on the plate <NUM>. The second plate <NUM> may press against the container <NUM> to help spread the fluid throughout the container and reduce sloshing during oscillation or other movement of the table and/or to keep the bag in close contact with the top surface of the plate to improve thermal conduction or benefit other processes associated with alternative apparatus provided on the top surface of the plate.

The door <NUM> and plate <NUM> may be solid and optionally may be clear, to permit the disposable container to be viewed while the door <NUM> is in a closed position. The embodiment may include alternatively configured hinge/latch connectors for the door. Multiple tubings <NUM>, <NUM>, <NUM> are shown, for example, extending from first and second ends of the disposable container <NUM>, which may pass through openings <NUM> and <NUM>. It will be appreciated that more or fewer tubings may extend from disposable container.

Claim 1:
A retaining table (<NUM>, <NUM>) for use with a fluid processing system comprising:
a plate (<NUM>, <NUM>) having a generally flat top surface with opposed first and second ends (125a, 125b, 725a, 725b) and opposed first and second lateral edges (127a, 127b, 727a, 727b) for supporting a disposable container (<NUM>);
a first retaining structure (<NUM>, <NUM>, <NUM>, <NUM>, <NUM>, <NUM>) connected to the plate (<NUM>, <NUM>) along the first end (125a, 725a),
a second retaining structure (<NUM>, <NUM>) connected to the plate (<NUM>, <NUM>) along the second end (125b, 725b); and
wherein the first retaining structure (<NUM>, <NUM>, <NUM>, <NUM>, <NUM>, <NUM>) further comprises a clip (<NUM>, <NUM>, <NUM>, <NUM>, <NUM>, <NUM>) including a base (<NUM>, <NUM>, <NUM>, <NUM>, <NUM>, <NUM>) and a mobile jaw (<NUM>, <NUM>, <NUM>, <NUM>, <NUM>, <NUM>) pivotally connected to the base (<NUM>, <NUM>, <NUM>, <NUM>, <NUM>, <NUM>), with the base (<NUM>, <NUM>, <NUM>, <NUM>, <NUM>, <NUM>) being fixedly or adjustably connected to the plate (<NUM>, <NUM>).