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0 | AGILE DATA DECISIONS, INC. | AI-DLCS: Artificial Intelligence for Data Labeling and Curation at Scale | Phase I | Department of Homeland Security | SBIR | 2,024 | 171,433 | The Department of Homeland Security (DHS) grapples with vast and diverse datasets collected daily, ranging from personal property scans to Stream of Commerce (SoC) data. To analyze and improve algorithms for detecting explosives and prohibited items, efficient curation and labeling are essential. However, DHS faces cha... |
1 | ATA ENGINEERING, INC. | Data-Driven Hypersonic Turbulence Modeling Toolset | Phase II | Department of Defense | STTR | 2,024 | 997,409 | Development of hypersonic aircraft and weapon systems has become a critical focus for the Department of Defense to maintain global strike and projection of force capabilities. Despite decades of research, traditional computational fluid dynamics (CFD) methods are either incapable of adequately predicting complex featur... |
2 | AVAWATZ COMPANY | CLARIFIER - Data Labeling and Curation at Scale (DLCS) for Machine Learning Algorithms | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,477 | The Data Labeling and Curation at Scale (DLCS) project will create a system called CLARIFIER, which aims to revolutionize the way large volumes of complex data are processed and utilized for machine learning (ML) applications within the Department of Homeland Security (DHS). The primary purpose of this work is to devel... |
3 | DEEP ANALYTICS LLC | Countering Synthetic Opioid Proliferation and OverDoses (CSOP-OD) | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,942 | Synthetic opioids have been responsible for most drug overdoses in the US in the last several years. Specifically, the use of fentanyl and fentanyl analogues have led to an alarming 7.5X increase in the number of overdoses from 2015 to 2021. Developing a strategy for countering the proliferation of synthetic opioids an... |
4 | Flexnode Inc | PREFAB MODULAR LIQUID-COOLED MICRO DATA CENTER | Phase II | Department of Energy | STTR | 2,024 | 1,880,681 | "To enable the future needs of efficient computing for edge data
centers, Flexnode and its partners, the University of Maryland (UMD), Boeing, Iceotope, SHoP
Architects, and Arup, propose to develop a prefabricated modular micro data center with
unprecedented energy efficiency and power density. The proposed system ... |
5 | Flexnode Inc | PREFAB MODULAR LIQUID-COOLED MICRO DATA CENTER | Phase I | Department of Energy | STTR | 2,024 | 306,808 | "To enable the future needs of efficient computing for edge data
centers, Flexnode and its partners, the University of Maryland (UMD), Boeing, Iceotope, SHoP
Architects, and Arup, propose to develop a prefabricated modular micro data center with
unprecedented energy efficiency and power density. The proposed system ... |
6 | Flexnode Inc | PREFAB MODULAR LIQUID-COOLED MICRO DATA CENTER | Phase II | Department of Energy | STTR | 2,024 | 1,312,462 | "To enable the future needs of efficient computing for edge data
centers, Flexnode and its partners, the University of Maryland (UMD), Boeing, Iceotope, SHoP
Architects, and Arup, propose to develop a prefabricated modular micro data center with
unprecedented energy efficiency and power density. The proposed system ... |
7 | GLOBAL TECHNOLOGY CONNECTION, INC. | MobiQkRad (Mobile QuickRadiological/Nuclear Source Localization) | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,994 | Global Technology Connection, Inc. (GTC), in collaboration with Arktis Detection Systems Inc., proposes the development of MobiQkRad (Mobile Quick Radiological/Nuclear Source Localization system). This innovative system is designed for rapid integration into standard vehicles, featuring lightweight components and advan... |
8 | Gamma Reality Inc. | 3D Radiation Mapping and Data Fusion for Mobile R/N Detection | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,559 | While vehicle-based radiation detection systems exist, they are limited in that 1) these systems are very large, heavy, and permanently installed in highly specialized vehicles with custom hardware and 2) provide limited contextual sensor data fusion and integration capabilities. As a result, the system can be rendered... |
9 | INTELLISENSE SYSTEMS INC | Safety-Attuned Liaison Using Software-Defined Radio | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,978 | To address the Department of Homeland Security (DHS) need for a software-defined radio for public safety, Intellisense Systems, Inc. (Intellisense) proposes to develop a new Safety-Attuned Liaison Using Software-Defined Radio (SALUS) device. This proposed radio device is based on a reconfigurable and interoperable modu... |
10 | INTELLISENSE SYSTEMS INC | Maritime Activity Recognition through Video Analytics and Human Adjudicated Learning | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,989 | To address the Department of Homeland Security (DHS) need for automated video analysis capabilities that monitor shore-based video cameras and alert operators on maritime activities of interest and anomalous activities, Intellisense Systems, Inc. (Intellisense) proposes to develop a new Maritime Activity Recognition th... |
11 | IONICSCALE LLC | FeDORA - Fentanyl Detection with Optimized Recognition Algorithms | Phase I | Department of Homeland Security | SBIR | 2,024 | 166,089 | IonicScale LLC is developing a handheld chemical sensor based on ion trap mass spectrometry (MS). The chemical analyzer has proven sub-isotopic mass resolution for gas phase analysis. For this project, it is proposed to demonstrated basic feasibility to extend the device's capability to sampling of solids (e.g., pills,... |
12 | LUTRIS, INC. | Flexible Software Defined Radio for Public Safety | Phase I | Department of Homeland Security | SBIR | 2,024 | 171,915 | This purpose of this work is to determine the feasibility of a software defined radio (SDR) platform that can support both legacy (e.g., analog FM and P25), current (LTE and 5G) and future standards.The compute processing requirements will be evaluated by running legacy and current protocols on modern processors with i... |
13 | MICHIGAN ENGINEERING SERVICES LLC | Data Labeling and Curation at Scale (DLCS) for Machine Learning Algorithms | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,318 | Homeland Security operations create a large amount of data from millimeter-wave and Computed Tomography X-ray detection systems.The Transportation Security Administration’s Electronic Baggage Screening Program provides an excellent example of the immense volume of screening conducted and X-ray image data generated, s... |
14 | PENDAR TECHNOLOGIES LLC | Detection of Synthetic Opioids using AI-Enhanced Difference Raman Spectroscopy | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,611 | Pendar Technologies is tackling the challenge posed by the rapid evolution of synthetic opioids, particularly fentanyl and its analogs, by developing a deep learning classifier for our Pendar X10 handheld Raman spectrometer. The effort would significantly advance the safety and detection capabilities of law enforcement... |
15 | PHYSICAL SCIENCES INC. | Spectral Data Fusion for the Detection of Existing and Emerging Synthetic Opioid Analogs | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,916 | Physical Sciences Inc. (PSI) proposes to develop a multimodal data fusion algorithm that is based on deep learning algorithms to detect previously unseen fentanyl analogs. The algorithm will be deployed on a hardware kit which contains a handheld Raman spectrometer and mass spectrometer (MS). The Raman spectrometer wil... |
16 | PHYSICAL SCIENCES INC. | Anomaly Detection in Video Streams via Expert LLM Interrogator | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,752 | Physical Sciences Inc. endeavors to create a video anomaly detection system that maintains constant surveillance of video footage while offering operators an interactive interface for obtaining detailed information on detected anomalies.The software will utilize state-of the art machine learning techniques to rapidly i... |
17 | PHYSICAL SCIENCES INC. | Modular and Adaptable Systems for Real-time Fusion of R/N and Contextual Data | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,987 | Physical Sciences Inc. (PSI) and our subcontractor Lawrence Berkeley National Laboratory (LBNL) propose to develop a suite of radiological/nuclear (R/N) detection and contextual sensor modules to enable real-time understanding and association of potential R/N threats in complex urban environments.The proposed Radiation... |
18 | SECURELOGIX CORPORATION | Enhanced Dispatchable Location Detection and Management System for 911 | Phase I | Department of Homeland Security | SBIR | 2,024 | 166,500 | SecureLogix’s proposed R&D initiative targets crucial challenges in VoIP-based emergency communications within the U.S. 9-1-1 system. This research focuses on addressing issues related to the accuracy and real-time positioning of VoIP callers during emergencies. Challenges include inaccurate location information, mob... |
19 | SKY PARK LABS LLC | SeaAlert: Video Analysis of Drug and Human Smuggling Activities | Phase I | Department of Homeland Security | SBIR | 2,024 | 175,000 | Sky Park Labs proposes SeaAlert, a video event detection tool that automatically detects anomalous events and identifies specific activities of interest. SeaAlert learns spatial and temporal patterns in a video to establish common objects and behaviors in a scene. The system detects and tracks objects of interest in th... |
20 | SYNCOPATED ENGINEERING INC | First Responder Cognitive Radio | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,841 | First Responders require a robust wireless communication capability that must work in emergency situations where the communications infrastructure may be degraded or unavailable.First Responders rely heavily on voice communications but also need access to data applications that are readily available via commercial cell... |
21 | TOYON RESEARCH CORPORATION | Software Defined Radio for Public Safety (SDR-PS) | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,999 | Toyon is proposing an SDR architecture that emphasizes a low-cost, modular design approach using a fully software controlled, multi-channel, wideband RF Front-End (RFFE) board. Toyon’s software define radio for public safety (SDR-PS) will be capable of hosting multiple open-source wireless communications software thr... |
22 | VADUM INC | Video Analysis of Drug & Human Smuggling Activities | Phase I | Department of Homeland Security | SBIR | 2,024 | 174,851 | Vadum will develop Alert Handling for Anomalous Behavior (AHAB), a pioneering machine learning (ML) system for automatic analysis of maritime video surveillance feeds to detect and flag multifaceted behaviors associated with drug smuggling. AHAB will utilize a novel multi-scale spatial and temporal analytics engine to ... |
23 | 123 See, Inc. | SBIR Phase II:Gaze-independent contactless autorefractor for self-serve eye exam kiosk. | Phase II | National Science Foundation | SBIR | 2,023 | 1,000,000 | The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to improve access to vision care and eyeglasses for all Americans through a self-serve, rapid vision exam kiosk for retail stores and public spaces. An estimated 175 million Americans suffer from blurry vision,... |
24 | 149 BIO LLC | Integrin-Targeted Novel Oral Therapeutics for Lupus Nephritis | Phase I | Department of Health and Human Services | SBIR | 2,023 | 306,500 | Project SummaryLupus nephritis (LN) remains the strongest predictor of morbidity and mortality for people with Systemic Lupus Erythematosus (SLE), an autoimmune disease disproportionately affecting women and minorities. The current standard of care for LN, glucocorticoids and immunosuppressive agents, has many side eff... |
25 | 21MedTech LLC | ARRAY: A novel polymeric mesh for prophylactic antibiotic protection of cardiac implantable electronic devices | Phase II | Department of Health and Human Services | SBIR | 2,023 | 999,978 | PROJECT SUMMARY 21MedTech, LLC is developing the ARRAYTM antibiotic-loaded envelope to address the need for novel methods to tackle rising rates of infections associated with cardiovascular implantable electronic devices (CIEDs). There were 1.5 million CIEDs implanted in 2011 and that number continues to grow. Between ... |
26 | 2INNOVATE LLC | STTR Phase I:A novel wall-mounted gait assist system to reduce the risk of injuries on stairs and level surfaces | Phase I | National Science Foundation | STTR | 2,023 | 275,000 | The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is a novel mechanical system which improves the safety of the elderly and disabled while walking on level surfaces and stairs. The novel, wall-mounted system will reduce the risks of injury by mechanically supporti... |
27 | 2PI INC | Chip-scale Large-aperture, Ultrawide-angle LiDAR | Phase I | National Aeronautics and Space Administration | STTR | 2,023 | 149,782 | In this program, we aim to pioneer a chip-scale packaged platform to enable efficient coupling from single-mode photonic integrated circuits (PICs) to a large-area (several millimeters in diameter or larger), diffraction-limited beam in response to Topic T8.07 Photonic Integrated Circuits. We further aim to leverage th... |
28 | 2PI INC | SBIR Phase I:High-performance, ultra-compact 3D sensor enabled by metasurface flat optics | Phase I | National Science Foundation | SBIR | 2,023 | 256,000 | The broader impact of this Small Business Innovation Research (SBIR) Phase I project lies in the development of a lightweight, ultra-compact 3D sensor offering enhanced performance compared to the current state-of-the-art. Existing sensors on consumer electronic devices, such as those on augmented/virtual reality heads... |
29 | 2SIGMA SCHOOL INC | Using Algorithmic Understanding of Student Comprehension of Computer Science Concepts to Support Teacherswith Personalized Student Recommendations | Phase II | Department of Education | SBIR | 2,023 | 1,000,000 | Not available |
30 | 2WITECH SOLUTIONS LLC | Fast Field Screening of PFAS in Non-Portable Waters.. | Phase I | Department of Health and Human Services | SBIR | 2,023 | 173,075 | Project Summary/Abstract: 2Witech Solutions LLC proposes a Phase I Small Business Innovation Research project to develop a portable electrochemical sensing device for quick field screening of trace PFAS in non-potable waters (groundwater, surface water, and wastewater) by combining its recent achievement in molecular- ... |
31 | 3 ROCKS ENGINEERING LLC | Flow Control Gate to Increase Irrigation, Water Quality Treatment, and Detention Efficiency | Phase I | Department of Agriculture | SBIR | 2,023 | 122,402 | The proposed device is a headgate that discharges water at a constant flow despite a variable headwater depth. This is possible due to a carefully designed adaptable float and track system. Through the funding of this grant the research could help greatly lower costs increase efficiency and decrease the size of water t... |
32 | 3-C INSTITUTE FOR SOCIAL DEVELOPMENT INC | Integrated software platform to enhance school mental health assessment and data-driven student services | Phase II | Department of Health and Human Services | SBIR | 2,023 | 943,672 | Abstract Mental health (MH) screening is critical to ensure early identification of youth MH needs. Schools are the most common setting for MH service delivery to children and adolescents, therefore, improving the capacity of school- based MH providers to easily access and use validated, high quality MH screening and a... |
33 | 3-C INSTITUTE FOR SOCIAL DEVELOPMENT INC | The SE-Learn Online Professional Development Platform for Enhanced Social Emotional Learning with Students | Phase I | Department of Health and Human Services | SBIR | 2,023 | 275,722 | Abstract Considerable evidence demonstrates how children’s social emotional (SE) development plays a significant role in their academic achievement, behavior, and emotional wellbeing. As the scientific base has grown supporting the positive impact of social and emotional learning (SEL) instructional practices, efforts ... |
34 | 361 INTERACTIVE LLC | Battle Damage Assessment Manager | Phase II | Department of Defense | SBIR | 2,023 | 1,799,973 | In response to SBIR Topic AF231-D029, 361 Interactive, LLC and our subcontractors the University of Dayton Research Institute (UDRI) and MAXAR, Inc., propose to develop the Battle Damage Assessment Manager (BDAM) Phase 2 Capability. Team 361 will develop |
35 | 361 INTERACTIVE LLC | CHART2 for JADC2 Environments | Phase I | Department of Defense | STTR | 2,023 | 149,938 | In the DoD, there is a pressing need to conduct research to identify the most effective Human-Autonomy Teaming (HAT) approaches within the near-future Joint All-Domain Command and Control Environment. This calls for a flexible simulation environment that |
36 | 3D ARRAY TECHNOLOGY LLC | Bifunctional nanocatalyst for one step drop-in diesel production using biomass derived syngas | Phase I | Department of Energy | SBIR | 2,023 | 200,000 | C56-10c-273795The proposed SBIR phase I project aims to develop an energy-efficient and sustainable bifunctional nanoarray-based catalyst system that coherently integrates syngas-to-wax hydrocarbons and wax hydrocarbons-to-diesel fuel conversions in a tandem one-step catalytic process for biomass-derived syngas convers... |
37 | 3D ARRAY TECHNOLOGY LLC | Nanoarray based monolithic contaminant filter for efficient submicron PM and NH3 removal | Phase I | Department of Energy | SBIR | 2,023 | 250,000 | C56-26e-273790The proposed SBIR phase I project aims to develop a new class of low cost nanoarray based monolithic contaminant filter for Clean Hydrogen Production and Separation from Coal Waste, Biomass, MSW and Plastics produced syngas. It is anticipated that the contaminant filter can capture > 95 % of the heavy ... |
38 | 3D FORTIFY INC | Advanced Hybrid Gradient Index Lenses via Additive Manufacturing of Low-Loss Materials | Phase I | Department of Defense | SBIR | 2,023 | 139,220 | Radio frequency (RF) systems are a key enabler of multi-domain mesh networked capabilities in the battlefield of the 21st century. As attritable and expendable unmanned platforms become more common, cost is becoming a larger constraining factor in system specifications. Current high-performance RF systems such as phase... |
39 | 3D-SENSIR INC | Asynchronous Geiger-mode photon counting arrays for deep space optical communications | Phase I | National Aeronautics and Space Administration | SBIR | 2,023 | 149,229 | Long range laser optical communications offer advantages of higher bandwidth and better accuracy over RF communications. NASA has demonstrated higher bandwidth data transmission using laser optical communication links. Recently, MIT-LL designed and delivered high sensitive Geiger-mode avalanche photodiode (Gm-APD) arra... |
40 | 3DEGREES, LLC | Accelerating Additive Manufacturing Materials Development for Enhanced Munitions | Phase II | Department of Defense | SBIR | 2,023 | 1,249,992 | 3Degrees’ TraceAM software is a streamlined platform designed to effectively organize, analyze, and deploy critical technical data packages related to Additive Manufactured parts. It is a secure and customizable interface ideal for use in munitions develo |
41 | 3DFlexible Inc | Lightweight Mirrors for Microsatellites and Small Satellites | Phase I | Department of Defense | STTR | 2,023 | 139,792 | The goal of this topic is to produce low density and high stiffness space mirrors. 3DFlexible has developed a new additive manufacturing process which incorporates fabricating parts via layer-by-layer printing using glass bubble paste (GBP) and sintering the parts into cellular solids. Cellular solids are structures th... |
42 | 3FATES-XRAY, INC. | SBIR Phase I:Single-shot X-ray Phase-contrast Imaging Using Deep Learning Approaches | Phase I | National Science Foundation | SBIR | 2,023 | 274,996 | The broader impact of this Small Business Innovation Research (SBIR) Phase I project relates to the benefits of next-generation X-ray imaging systems. The proposed single-shot platform overcomes the current barriers to widespread commercialization of Differential Phase Contrast (DPC) X-ray imaging. If successful, the s... |
43 | 3NEWABLE LLC | Preventing Biofouling of Oceanographic Sensors Using UV Illumination Powered by a Compact Wave Energy Converter | Phase II | Department of Energy | SBIR | 2,023 | 1,149,047 | Oceanographic instrumentation is typically located far from power grids, and in environments prone to biological growth that covers scientific instruments and interferes with data collection. The objectives of this program are to extend the deployment period – thereby reducing costs and ship emissions – by capturing re... |
44 | 410 MEDICAL, INC. | Transfusion and Endovascular Resuscitation v.1.0 (TiER-1) platform | Phase I | Department of Defense | SBIR | 2,023 | 74,938 | Non-compressible torso hemorrhage (NCTH) is a leading cause of potentially survivable death in United States (U.S.) warfighters and commonly occurs after traumatic injury. A study of 4,596 battlefield fatalities from Operation Iraqi Freedom and Operation Enduring Freedom determined that hemorrhage accounted for 91% of ... |
45 | 4D MAKER, LLC | Design and prototyping of a novel lightweight wave energy converter (WEC) for marine energy harvesting and self-powered marine monitoring | Phase I | Department of Energy | STTR | 2,023 | 200,000 | This project will develop and prototype a new class of lightweight, high-performance wave energy converters for short-duration deployment and installation in smaller-scale applications. It is anticipated that the size of the wave energy converter will be in meter or submeter scale, the weight is in kilogram level or le... |
46 | 60Hertz Incorporated | Artificial Intelligence (AI) based algorithms for predictive maintenance using NOAA data-sets for renewable energy assets | Phase II | Department of Commerce | SBIR | 2,023 | 649,950 | This research aims to develop decision support tools for better
maintenance and planning of renewable energy generation and storage assets using
atmospheric, local weather, and on-ground environmental data blended with site-, regional- and
national-generation data. The study will use a combination of these data to u... |
47 | 7 Hills Pharma LLC | 7HP349, an Integrin Activator to Treat Patients With anti-PD-1 Resistant Solid Tumors | Phase II | Department of Health and Human Services | SBIR | 2,023 | 999,200 | PROJECT SUMMARY/ABSTRACT Immuno-oncology (IO) therapies, particularly immune checkpoint inhibitors (ICIs) such as nivolumab (anti-PD- 1) and ipilimumab (anti-CTLA-4) have made rapid advances in inducing remarkable response rates in patients in a variety of solid tumors. However, over 40% of melanoma patients develop se... |
48 | 7 Hills Pharma LLC | 7HP349, an oral integrin activator to augment effectiveness of pre-exposure influenza vaccination | Phase II | Department of Health and Human Services | SBIR | 2,023 | 928,224 | PROJECT SUMMARY/ABSTRACT Americans aged ≥65 years accounted for 57% and 75% of all influenza-related hospitalizations and deaths, respectively, in the 2019-20 season, despite a vaccination rate of ~68%. Flu vaccine effectiveness is lower in the elderly than in younger adults, requiring either a high-dose (Fluzone® HD) ... |
49 | 8D PHOTONICS LLC | Non-Destructive Cryogenic Wafer Mapper for Infrared Detector Material Screening | Phase II | Department of Defense | SBIR | 2,023 | 1,782,519 | Quality control tools for compound semiconductor operations are desired to provide cost and time savings. 8D Photonics (www.8Dphotonics.com) has been providing the infrared community with the capability to perform cryogenic wafer mapping of minority carrier lifetime and photoluminescence spectra since its inception in ... |
50 | 9 CORNER SOLUTIONS LLC | Runtime Lightweight Hardware-Assisted Machine Learning-based Cyber Attack Detection | Phase I | Department of Homeland Security | SBIR | 2,023 | 149,972 | The grand vision of the Internet-of-Things (IoT) boasts a fully connected, global network of devices or systems connecting every imaginable thing. Amelioration of miniature embedded computing devices into the consumer and industrial markets with enabled connectivity to the Internet towards smart and intelligent feature... |
51 | A & B Foundry LLC | Vertically Integrated Platform to Rapidly Manufacture Non-Procurable and Spare Parts | Phase I | Department of Defense | STTR | 2,023 | 73,552 | The Air Force faces significant challenges with sourcing spare parts for its current and aging aircraft. This is largely a result of vendor lock, a shrinking defense industrial base, and difficulties in obtaining replacement parts that meet the necessary |
52 | A & B Foundry LLC | Electrical Fuel Pump | Phase I | Department of Defense | SBIR | 2,023 | 99,408 | Maintaining the many types of legacy weapon systems within the Department of Defense (DoD) is an enormous task, made more challenging by the aging of many of these systems. Some of the weapons were designed over 50 years ago and are now facing a shortage of sustainment components due to obsolescence. The situation is f... |
53 | A & P TECHNOLOGY, INC. | Innovative, Automated Inline Inspection for High Quality, High-Rate Production of Braided Composite Components for Hypersonics and Military Aircraft | Phase II | Department of Defense | SBIR | 2,023 | 1,245,479 | The U.S. Air Force (USAF) and Advanced Air Mobility (AAM) companies require high rate, lower cost composite manufacturing technologies for Collaborative Combat Aircraft (CCA) and revolutionary air transport vehicles to achieve aggressive cost objectives w |
54 | A T A, LLC | Streaming Platform for Object Tracking Analytics | Phase II | Department of Defense | SBIR | 2,023 | 1,496,680 | ATA’s proposed innovation is SPOT-lyt, the Streaming Platform for Object Tracking Analytics, a system for real-time and forensic tracking and analysis of moving objects with cutting-edge capabilities in data fusion, simulation, machine learning, and streaming analytics platform operations. For Phase II of this SBIR eff... |
55 | A-TERRA LLC | High Purity Oxygen Separation from a Pyrolysis Gas Mixture by Rapid Solid Oxide Ion Transport | Phase II | National Aeronautics and Space Administration | SBIR | 2,023 | 900,000 | With the Artemis program, NASA currently plans to land the first woman and next man on the moon by 2025, using innovative technologies to explore more of the lunar surface than ever before. The need for oxygen extraction from lunar regolith has been identified by the STMD (Space Technology Mission Directorate). Success... |
56 | A.T.E. SOLUTIONS, INC. | Automated Measurement of Passive Devices in Printed Circuit Assemblies | Phase I | Department of Defense | SBIR | 2,023 | 196,986 | Passive components, such as resistors, capacitors and inductors, present a unique complication when reverse engineering is attempted. Automated measurements of device values on populated printed circuit boards - resistance, capacitance and inductance - is complicated by the network effect of neighboring components co... |
57 | A10 SYSTEMS INC | Multifunctional Multi-channel Scalable Cognitive Electromagnetic wide band Transceiver (MUSCET) | Phase I | Department of Defense | SBIR | 2,023 | 149,549 | AiRANACULUS team proposes Multifunctional Multi-channel Scalable Cognitive Electromagnetic wide band Transceiver (MUSCET) System that will meet and exceed Air Force’s requirements to develop a Low-Cost Scalable Ultrawideband Receiver. MUSCET will provide a distributed multi-function RF sensing capability for attritable... |
58 | AALMV INC. | SBIR Phase I:Mission Planning Methods and Simulated Crisis Management Framework to teach STEM to Underserved Youth | Phase I | National Science Foundation | SBIR | 2,023 | 270,755 | The broader/ commercial impact of this Small Business Innovation Research (SBIR) Phase I project is in addressing the unemployment of youth, primarily in underserved communities, across the United States by providing an online, collaborative gaming environment to educate, train, and provide Science, Technology, Enginee... |
59 | AAVOGEN INC | Development of optimized adeno-associated viral capsids for muscle gene therapy | Phase I | Department of Health and Human Services | SBIR | 2,023 | 140,152 | PROJECT SUMMARY. Gene therapeutics offer hope to many patients with rare muscle and neuromuscular diseases. Despite some early successes, several serious off-target safety concerns have compromised their development due to hepatic toxicities and related immune responses to the adeno-associated viral (AAV) vectors. The ... |
60 | ABBRATECH INC. | Method for the validation by Western analysis of affinity reagents against post-translationally modified proteins. | Phase II | Department of Health and Human Services | SBIR | 2,023 | 1,121,971 | ABSTRACT Antibodies (Abs) are commonly employed in biomedical research to identify and quantify target proteins. However, the specificity, sensitivity and reliability of these Abs can be variable, which is a significant concern in the scientific community. The use of an incorrect Ab can result in misleading or inaccura... |
61 | ABBRATECH INC. | Structure-guided neutralizing antibodies developed using EpiVolve technology | Phase I | Department of Health and Human Services | SBIR | 2,023 | 296,100 | Abstract Current strategies for developing neutralizing Abs are not effective and typically involve screening IgGs from recovered patients. Pandemic viruses evolve for mutations that can shield their epitopes from host immune surveillance system, so a lot of important epitopes will be missed. Even after neutralizing Ab... |
62 | ABBRATECH INC. | T-cell receptor mimic affinity reagent generation using an in vivo novel immunogen strategy | Phase I | Department of Health and Human Services | SBIR | 2,023 | 295,460 | ABSTRACT Current therapeutic antibodies target the cell surface and within the external cellular environment. Yet intracellular proteins make up half of the proteome. Having a facile means of targeting those intracellular proteins for the generation of therapeutic antibodies would be highly desirable. Targeting MHC com... |
63 | ABBRATECH INC. | Platform for the High Throughput Generation and Validation of Affinity Reagents | Phase II | Department of Health and Human Services | SBIR | 2,023 | 1,080,240 | ABSTRACT We present a complete platform for the rapid generation and validation of recombinant mAbs. The innovations of this proposal include: (1) the pATHENA vector system for overnight conversion of phage display scFv or Fab clones into IgG molecules, (2) the Epivolve method for the isolation of site-specific Abs, (3... |
64 | ABILITA BIO, INC. | Novel Anti-CCR8 VHH for the Treatment of NSCLC | Phase I | Department of Health and Human Services | SBIR | 2,023 | 399,424 | Summary The advent of immune checkpoint inhibitor (ICI) therapies has dramatically changed the treatment landscape for non-small cell lung cancer (NSCLC). However, most patients treated with ICIs are either non-responders or develop progressive disease (PD), despite an initial response to therapy. One of the mechanisms... |
65 | ABL SPACE SYSTEMS COMPANY | ADAPTATION EFFORTS AND A LIVE DEMONSTRATION TO PROVIDE OPERATIONAL FLEXIBILITY FOR LOW-COST TACTICAL LAUNCHES | Phase II | Department of Defense | SBIR | 2,023 | 14,999,988 | ABL’s concept for the STRATFI subject solution is to enable operational flexibility for responsive launch. In other words, ABL seeks to give users of responsive launch the ability to task payloads, launch sites, and target orbits as needed. This is made e |
66 | ABOVE: ORBITAL INC. | On-Orbit Manufacturing of Thin-Film Solar Photovoltaics | Phase I | Department of Defense | SBIR | 2,023 | 74,997 | Orbital Assembly (OA), along with Ascent Solar Technologies, Inc. (ASTI), are developing a solar heated crucible for the manufacturing of lightweight, thin-film solar photovoltaics (PV) on orbit. This technology will enable the development of mass-efficie |
67 | ABOVE: ORBITAL INC. | Orbital Assembly - Beamed Energy Receiver | Phase II | Department of Defense | SBIR | 2,023 | 1,688,745 | Orbital Assembly is currently developing a beamed energy receiver for the use in commercial space stations. No technology to receive beamed power currently exists, and this technology will be applicable to US Government spacecraft with little modification |
68 | ABSTRACTIVE HEALTH, INC. | SBIR Phase I:A tool to automate a narrative patient summary of the medical chart for outpatient physicians | Phase I | National Science Foundation | SBIR | 2,023 | 274,991 | The broader impact /commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the development of a machine learning-enabled medical record summarization tool designed to provide a narrative summary that can aid physicians in patient care. On average, physicians spend just 3 minutes revie... |
69 | ABVACC, INC. | Monoclonal Antibody Cocktail for Treatment of Marburg Virus Disease | Phase I | Department of Health and Human Services | SBIR | 2,023 | 293,392 | Project Summary Ebola (EBOV) and Marburg (MARV) viruses cause hemorrhagic fever disease in humans and nonhuman primates (NHPs) with case-fatality rates as high as 90%. The 2013-2016 Ebola Virus Disease (EVD) outbreak led to over 28,000 cases and 11,000 deaths and took an enormous toll on the economy of West African nat... |
70 | ABVACC, INC. | Prophylactic Immunotherapy for Marburg Virus Disease Outbreak Control | Phase II | Department of Health and Human Services | SBIR | 2,023 | 986,248 | The ebolaviruses (EBOV, SUDV, BDBV) and marburgviruses (MARV and RAVV), cause periodic outbreaks of severe viral hemorrhagic fever with very high mortality rates. The 2013-2016 Ebola virus disease (EVD) outbreak in West Africa highlighted the serious nature of a filovirus epidemic and its regional and global implicatio... |
71 | ABZYME THERAPEUTICS LLC | Novel immune-escape uricase for treatment of hyperuricemia | Phase I | Department of Health and Human Services | SBIR | 2,023 | 299,999 | Abstract. High serum urate levels (hyperuricemia) and subsequent monosodium urate crystal deposition cause gout, the most common inflammatory arthritis in men and postmenopausal women. Gout affects an estimated 9.2 million adults in the United States. Hyperuricemia is also a major complication in patients with tumor ly... |
72 | ACADIAN RESEARCH & DEVELOPMENT LLC | Value-added graphene materials from woody resources | Phase I | Department of Agriculture | STTR | 2,023 | 175,000 | This project will demonstrate the utilization of wood biomass feedstock to produce grapheneproducts through a less expensive more environmentally friendly process. The wood feedstock isfirst pyrolyzed to biochar then the process developed at the University of Wyoming converts thebiochar to graphene oxide a viable produ... |
73 | ACATECHOL, INC | Hybrid repellant-antimicrobial gemini coatings for prevention of catheter-associated bloodstream infections | Phase I | Department of Health and Human Services | SBIR | 2,023 | 273,485 | Project Summary/Abstract Over 20% of the hemodialysis patients develop life-threatening central line-associated bloodstream infections (CLABSIs). According to the CDC, rt250,000 CLABSIs, having mortality rates of 14-40%, occur in the US annually, and among them rt100,000 cases are directly related to hemodialysis centr... |
74 | ACCELEVIR DIAGNOSTICS LLC | PROVIRAL SEQUENCING DRIVEN DEVELOPMENT OF ENHANCED IPDAV2 WITH GLOBAL HIV-1 GROUP M COVERAGE TO SUPPORT WORLDWIDE CURE AND CLINICAL TRIALS | Phase II | Department of Health and Human Services | SBIR | 2,023 | 2,000,000 | The objective of this program is to develop and commercialize sequence-based HIV reservoir assays for clinical HIV cure interventions. The assay should be designed as an analytical tool to monitor the size of the replication-competent HIV reservoir in clinical research and in prospective clinical trials. An additional ... |
75 | ACCRETE AI GOVERNMENT LLC | Reverse Engineering for DAF Obsolete Parts (Argus for Reverse Engineering) | Phase I | Department of Defense | SBIR | 2,023 | 74,649 | Accrete is an enterprise Artificial Intelligence (AI) company that works with multiple Fortune 500 companies, the Defense Intelligence Agency (DIA), and others to solve ultrahard tasks like supply chain management/awareness, identifying obscure entertainm |
76 | ACCRETE AI GOVERNMENT LLC | Project Kepler - Social Media Exploitation Analytics Platform | Phase I | Department of Defense | SBIR | 2,023 | 149,239 | Redacted |
77 | ACCRETE AI GOVERNMENT LLC | Argonavis for Supply Chain Shortages (Argus for Supply Chain Logistics Resilience) | Phase I | Department of Defense | SBIR | 2,023 | 74,649 | Accrete is an enterprise Artificial Intelligence (AI) company that works with multiple Fortune 500 companies, the Defense Intelligence Agency (DIA), and others to solve ultrahard tasks like supply chain management/awareness, identifying obscure entertainm |
78 | ACCRETE AI GOVERNMENT LLC | Analyzing Narrative Evolution Across Social Networks | Phase I | Department of Defense | SBIR | 2,023 | 209,226 | Accrete proposes developing a social media exploitation platform to achieve a revolutionary information advantage for the command. It will: map social media networks, measure engagement and quantify influence, track narratives and trace mis-/disinformation to its source. The adapted version will automatically translate... |
79 | ACELLENT TECHNOLOGIES INC | In-situ On-Orbit Monitoring and Inspection of Satellite Structures | Phase II | Department of Defense | STTR | 2,023 | 1,499,999 | Space-based assets form the backbone of today’s communication, navigation, and defense industries. Key assets, such as satellites, are highly vulnerable to unexpected damage during their lifetimes from impacts with other vehicles, micrometeoroids, and spa |
80 | ACELLENT TECHNOLOGIES INC | Flexible Multifunctional Structural Health Monitoring Systems for Inflatable Space Habitat Structures | Phase II | National Aeronautics and Space Administration | SBIR | 2,023 | 845,308 | Inflatable structures are being pursued as candidates for long-term habitats in space. The ability to monitor and assess the structural health of an inflatable module is an important factor in determining the feasibility of using inflatable technologies for habitat requirements, especially in the presence of micrometeo... |
81 | ACHIEWELL LLC | Photocured Hydropower Repair Coatings | Phase I | Department of Energy | SBIR | 2,023 | 199,985 | Hydropower facilities are under constant exposure to extreme moisture conditions. When metal components such as gates and penstocks are exposed to water they experience rusting, corrosion and ultimately parts failure. Coatings are the primary method to prevent corrosion of metal systems, they act as a barrier preventin... |
82 | ACLID, INC. | A biosecurity platform for the identification of natural and engineered biological threats | Phase I | Department of Defense | SBIR | 2,023 | 74,933 | Aclid is adapting its commercial platform for Air Force needs. End-users will receive early warnings when human error risks the creation of a novel or existing biothreat. At the same time, end-users will be alerted if nefarious actors attempt to generate a man-made biothreat anywhere in the world. Aclid is a proprietar... |
83 | ACME ATRONOMATIC, LLC | Enhanced Tactical Decision Support through Nowcasting-to-NWP (N2N) Data Fusion of Cloud Evolution | Phase I | Department of Defense | STTR | 2,023 | 139,946 | In a partnership with the Space Sciences and Engineering Center at the University of Wisconsin-Madison, ACME AtronOmatic d/b/a MyRadar, proposes to develop an end-to-end, nowcasting-to-NWP (N2N) suite that incorporates an artificial intelligence nowcasting model, output from high-quality numerical weather prediction (N... |
84 | ACME ATRONOMATIC, LLC | Orbital Wildfire Resilience (OWR) Phase II will demonstrate a small satellite platform to provide actionable insight to mitigate the growing risks of wildfires for key stakeholder communities | Phase II | Department of Commerce | SBIR | 2,023 | 649,864 | The Orbital Wildfire Resilience (OWR) project comprises the innovative combination of MyRadar’s
miniaturized satellite technology, onboard Artificial Intelligence (AI) processing, and wide-reaching
dissemination platform to improve the wildfire hazard resilience of stakeholders. This research
facilitates the develop... |
85 | ACOUSTICABIO, INC. | Enabling Subcutaneous Delivery of Therapeutic Monoclonal Antibodies via Hydrogel Microparticles | Phase I | Department of Health and Human Services | SBIR | 2,023 | 324,500 | ABSTRACT Monoclonal antibodies (mAbs) provide unchallenged specificity compared to small molecules, representing a growing market of 150+ billion dollars. Due to their structural complexity and poor stability, however, they remain difficult to formulate at high concentrations, making intravenous (IV) delivery of mAbs t... |
86 | ACREE TECHNOLOGIES INCORPORATED | Anti-Fog Coatings for Spacesuit Helmets | Phase I | National Aeronautics and Space Administration | SBIR | 2,023 | 149,994 | The purpose of this project is to demonstrate the feasibility of applying a permanent anti-fog coating on the interior of polycarbonate spacesuit helmets. The coating uses a mechanically resilient and permanent Superhydrophobic (SH) coating consisting of an optically transparent Diamond Like Carbon (DLC) and a proven 2... |
87 | ACREE TECHNOLOGIES INCORPORATED | Advanced High Temperature Sensors for Hypersonic Vehicles | Phase I | National Aeronautics and Space Administration | SBIR | 2,023 | 149,999 | Hypersonic flight is currently an extremely important research area that represents a disruptive technology with the potential to revolutionize modern aviation, military defense, and space exploration.nbsp; Advancements in high-speed vehicle development are possible if insights can be gained, analyzed, and used to crea... |
88 | ACTIOX LLC | A Sensor Patch for Continuous Monitoring of Sodium, Glucose, and Ketones Concurrently and in Real-Time | Phase I | Department of Health and Human Services | SBIR | 2,023 | 242,832 | Precision nutrition is an emerging field that recognizes human physiological individuality and exploits it to procure dietary recommendations and/or interventions to improve one’s health and aid in disease prevention, and management. Metabolic profiling, which involves quantifying biochemical changes caused by dietary ... |
89 | ACTIOX LLC | Discreet Wearable device for Continuous Real-time Monitoring of Alcohol | Phase II | Department of Health and Human Services | SBIR | 2,023 | 1,047,417 | Abstract
Excessive alcohol use remains a leading preventable cause of death and disability in the United States.
According to the Centers for Disease Control and Prevention (CDC), an average of 95,158 alcohol-attributable
deaths (261 deaths per day) is reported only in the United States, with associated annual costs... |
90 | ACTIOX LLC | A wearable device for continuous monitoring of methadone | Phase I | Department of Health and Human Services | SBIR | 2,023 | 319,754 | Opioid overdose is a significant public health problem that has been escalating in recent years. Based on the statistics from the Centers for Disease Control and Prevention (CDC), the number of overdose-related deaths surpassed 100,000 from April 2020 to April 2021. This is a significant increase in overdose cases rela... |
91 | ACTOPROBE LLC | Scanning Probe Microscopy with Active Optical Probes: A Novel Approach to Measurements and Nanomanufacturing | Phase I | Department of Commerce | SBIR | 2,023 | 99,909 | Actoprobe LLC proposes development of a novel class of Atomic Force Microscopy (AFM) active optical probes
with dramatically increased sensitivity and spatial resolution for Near-Field Optical Nanospectroscopy and
Nanoscopy. The innovation is accomplished by integrating a diode laser source and a photodetector into a... |
92 | ACTUATED MEDICAL, INC. | Development of an Oscillated Insertion tool to Eliminate Surgically Induced Neurodegeneration for Optical Neuroimaging of Cognitive Aging and Dementia | Phase I | Department of Health and Human Services | SBIR | 2,023 | 406,263 | This Phase I SBIR develops a system for gentle and accurate insertion of large optical neuroscience probes (e.g., GRIN lenses) to improve outcomes in aging research. Additionally, the project supports Qingguang Zhang. Ph.D. through the NIA Research and Entrepreneurial Development Immersion (REDI) program at a small bus... |
93 | ACTUATED MEDICAL, INC. | Development of an Acoustic Implant Protection System to Improve Performance and Longevity of Neural Interfaces | Phase II | Department of Health and Human Services | SBIR | 2,023 | 1,204,215 | This SBIR Fast-track finalizes, tests, and commercializes the Acoustic Implant Protection (AIP) system, which uses the application of precision acoustic fields to penetrating neural implants to prevent electrode impedance rise and improve implant longevity. This submission is in response to: Notice of Special Interest ... |
94 | ACUITY.AI, INC. | SBIR Phase I:Improved image compression targeting machine learning based detection algorithms | Phase I | National Science Foundation | SBIR | 2,023 | 274,623 | The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is in reducing the sizes of earth observation images, thereby saving millions of dollars on transmission, storage and processing costs. Storage and processing costs account for a large portion of costs for earth ob... |
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