format stringclasses 1
value | id stringlengths 15 15 | lastModified null | name stringlengths 30 116 | submissionDate stringdate 2009-06-03 00:00:00 2021-09-11 00:00:00 | submitter stringlengths 8 27 | url stringlengths 41 41 | pubmedid stringlengths 12 27 | synopsis stringlengths 566 3.16k | modelfiles listlengths 1 1 | sbml_string stringlengths 9.05k 367k | idtype stringclasses 2
values | pmcid stringlengths 7 10 | abstract stringlengths 10 3.11k | antimony_string stringlengths 0 31.5k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SBML | BIOMD0000001041 | null | Kimmel2021 - T cell competition and stochastic extinction events in CAR T cell therapy | 2021-09-01T00:00:00Z | Emilia Chen | https://www.biomodels.org/BIOMD0000001041 | PMID:33757357 | Chimeric antigen receptor (CAR) T cell therapy is a remarkably effective immunotherapy that relies on <i>in vivo</i> expansion of engineered CAR T cells, after lymphodepletion (LD) by chemotherapy. The quantitative laws underlying this expansion and subsequent tumour eradication remain unknown. We develop a mathematica... | [
"Kimmel2021.xml"
] | <?xml version='1.0' encoding='UTF-8' standalone='no'?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<model id="Kimmel2021___T_cell_competition_and_stochastic_extinction_events_in_CAR_T_cell_therapy" metaid="COPASI0" name="Kimmel2021 - T cell competition and stochastic extinction event... | pmid | PMC8059581 | Chimeric antigen receptor (CAR) T cell therapy is a remarkably effective immunotherapy that relies on in vivo expansion of engineered CAR T cells, after lymphodepletion (LD) by chemotherapy. The quantitative laws underlying this expansion and subsequent tumour eradication remain unknown. We develop a mathematical model... | // Created by libAntimony v3.1.3
model *Kimmel2021___T_cell_competition_and_stochastic_extinction_events_in_CAR_T_cell_therapy()
// Compartments and Species:
compartment compartment_;
species Normal_T_cells in compartment_, CAR_T_cells in compartment_, Antigen_presenting_tumour_cells in compartment_;
species $... |
SBML | BIOMD0000001013 | null | Leon-Triana2021 - Competition between tumour cells and single-target CAR T-cells | 2021-07-12T00:00:00Z | Emilia Chen | https://www.biomodels.org/BIOMD0000001013 | PMID:33572301 | Chimeric antigen receptor (CAR)-T cell-based therapies have achieved substantial success against B-cell malignancies, which has led to a growing scientific and clinical interest in extending their use to solid cancers. However, results for solid tumours have been limited up to now, in part due to the immunosuppressive ... | [
"Leon-Triana2021 - eqs 1 and 2.xml"
] | <?xml version='1.0' encoding='UTF-8' standalone='no'?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<model id="Leon_Triana2021___Competition_between_tumour_cells_and_single_target_CAR_T_cells" metaid="COPASI0" name="Leon-Triana2021 - Competition between tumour cells and single-target ... | pmid | PMC7916125 | (CAR)-T cell-based therapies have achieved substantial success against different haematological malignancies. However, results for solid tumours have been limited up to now, in part due to the fact that the immunosuppressive tumour microenvironment inactivates CAR-T cell clones. In this paper we study mathematically th... | // Created by libAntimony v3.1.3
model *Leon_Triana2021___Competition_between_tumour_cells_and_single_target_CAR_T_cells()
// Compartments and Species:
compartment Solid_tumour;
species CAR_T_cells in Solid_tumour, Tumour_cells in Solid_tumour;
// Reactions:
CAR_T_cell_proliferation: => CAR_T_cells; Solid_... |
SBML | BIOMD0000001014 | null | Leon-Triana2021 - Competition between tumour cells and dual-target CAR T-cells | 2021-07-12T00:00:00Z | Emilia Chen | https://www.biomodels.org/BIOMD0000001014 | PMID:33572301 | Chimeric antigen receptor (CAR)-T cell-based therapies have achieved substantial success against B-cell malignancies, which has led to a growing scientific and clinical interest in extending their use to solid cancers. However, results for solid tumours have been limited up to now, in part due to the immunosuppressive ... | [
"Leon-Triana2021 (eqs 3-6).xml"
] | <?xml version='1.0' encoding='UTF-8' standalone='no'?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<model id="Leon_Triana2021___Competition_between_tumour_cells_and_dual_target_CAR_T_cells" metaid="COPASI0" name="Leon-Triana2021 - Competition between tumour cells and dual-target CAR ... | pmid | PMC7916125 | (CAR)-T cell-based therapies have achieved substantial success against different haematological malignancies. However, results for solid tumours have been limited up to now, in part due to the fact that the immunosuppressive tumour microenvironment inactivates CAR-T cell clones. In this paper we study mathematically th... | // Created by libAntimony v3.1.3
model *Leon_Triana2021___Competition_between_tumour_cells_and_dual_target_CAR_T_cells()
// Compartments and Species:
compartment On_tumour, Off_tumour;
species CAR_T_cells_on_tumour in On_tumour, Tumour_cells in On_tumour, CAR_T_cells_off_tumour in Off_tumour;
species B_cells i... |
SBML | BIOMD0000001024 | null | Chaudhury2020 - Lotka-Volterra mathematical model of CAR-T cell and tumour kinetics | 2021-08-05T00:00:00Z | Emilia Chen | https://www.biomodels.org/BIOMD0000001024 | PMID:33205434 | Chimeric antigen receptor T cell (CAR-T cell) therapies have shown significant efficacy in CD19+ leukemias and lymphomas. There remain many challenges and questions for improving next-generation CAR-T cell therapies, and mathematical modeling of CAR-T cells may play a role in supporting further development. In this rev... | [
"Chaudhury2020 Eq 4-5.xml"
] | <?xml version='1.0' encoding='UTF-8' standalone='no'?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" version="4">
<model id="Chaudhury2020___Lotka_Volterra_mathematical_model_of_CAR_T_cell_and_tumour_kinetics" metaid="COPASI0" name="Chaudhury2020 - Lotka-Volterra mathematical model of CAR-T cell an... | pmid | NoPMCID | NoAbstract | // Created by libAntimony v3.1.3
model *Chaudhury2020___Lotka_Volterra_mathematical_model_of_CAR_T_cell_and_tumour_kinetics()
// Compartments and Species:
compartment Whole_organism_blood;
species Expanding_CAR_T_cells in Whole_organism_blood, Tumor_cells in Whole_organism_blood;
// Reactions:
Expanding_CAR... |
SBML | BIOMD0000001025 | null | Chaudhury2020 - EC50 expansion and killing mathematical model of CAR-T cell and tumour kinetics | 2021-08-05T00:00:00Z | Emilia Chen | https://www.biomodels.org/BIOMD0000001025 | PMID:33205434 | "Chimeric antigen receptor T cell (CAR-T cell) therapies have shown significant efficacy in CD19+ le(...TRUNCATED) | [
"Chaudhury2020 Eq 7-9.xml"
] | "<?xml version='1.0' encoding='UTF-8' standalone='no'?>\n<sbml xmlns=\"http://www.sbml.org/sbml/leve(...TRUNCATED) | pmid | NoPMCID | NoAbstract | "// Created by libAntimony v3.1.3\nmodel *Chaudhury2020___EC50_expansion_and_killing_mathematical_mo(...TRUNCATED) |
SBML | MODEL2109110005 | null | Chaudhury2020 - First order expansion model of CAR-T cell and tumour kinetics | 2021-09-11T00:00:00Z | Emilia Chen | https://www.biomodels.org/MODEL2109110005 | PMID:33205434 | "Chimeric antigen receptor T cell (CAR-T cell) therapies have shown significant efficacy in CD19+ le(...TRUNCATED) | [
"Chaudhury2020 Eq S1-S3.xml"
] | "<?xml version='1.0' encoding='UTF-8' standalone='no'?>\n<sbml xmlns=\"http://www.sbml.org/sbml/leve(...TRUNCATED) | pmid | NoPMCID | NoAbstract | "// Created by libAntimony v3.1.3\nmodel *Chaudhury2020___First_order_expansion_model__Eq__S1_S3()\n(...TRUNCATED) |
SBML | BIOMD0000001042 | null | Makhlouf2020 - No treatment model of the role of CD4 T cells in tumor-immune interactions | 2021-09-06T00:00:00Z | Emilia Chen | https://www.biomodels.org/BIOMD0000001042 | PMID:32148558 | "Mathematical modelling has been used to study tumor-immune cell interaction. Some models were propo(...TRUNCATED) | [
"Makhlouf2020.xml"
] | "<?xml version='1.0' encoding='UTF-8' standalone='no'?>\n<sbml xmlns=\"http://www.sbml.org/sbml/leve(...TRUNCATED) | pmid | PMC7049850 | "Mathematical modelling has been used to study tumor-immune cell interaction. Some models were propo(...TRUNCATED) | "// Created by libAntimony v3.1.3\nmodel *Makhlouf2020___No_treatment_model_of_the_role_of_CD4_T_cel(...TRUNCATED) |
SBML | BIOMD0000001011 | null | Leon-Triana2020 - CAR T-cell therapy in B-cell acute lymphoblastic leukaemia | 2021-07-12T00:00:00Z | Emilia Chen | https://www.biomodels.org/BIOMD0000001011 | 10.1016/j.cnsns.2020.105570 | "Immunotherapies use components of the patient immune system to selectively target can- cer cells. T(...TRUNCATED) | [
"Leon-Triana2020 (eqs 4).xml"
] | "<?xml version='1.0' encoding='UTF-8' standalone='no'?>\n<sbml xmlns=\"http://www.sbml.org/sbml/leve(...TRUNCATED) | doi | NoPMCID | NoAbstract | "// Created by libAntimony v3.1.3\nmodel *Leon_Triana2020___CAR_T_cell_therapy_in_B_cell_acute_lymph(...TRUNCATED) |
SBML | BIOMD0000001012 | null | "Leon-Triana2020 - CAR T-cell therapy in B-cell acute lymphoblastic leukaemia with contribution from(...TRUNCATED) | 2021-07-12T00:00:00Z | Emilia Chen | https://www.biomodels.org/BIOMD0000001012 | 10.1016/j.cnsns.2020.105570 | "Immunotherapies use components of the patient immune system to selectively target can- cer cells. T(...TRUNCATED) | [
"Leon-Triana2020 (eqs 3).xml"
] | "<?xml version='1.0' encoding='UTF-8' standalone='no'?>\n<sbml xmlns=\"http://www.sbml.org/sbml/leve(...TRUNCATED) | doi | NoPMCID | NoAbstract | "// Created by libAntimony v3.1.3\nmodel *Leon_Triana2020___CAR_T_cell_therapy_in_B_cell_acute_lymph(...TRUNCATED) |
SBML | BIOMD0000000824 | null | Lewkiewics2019 - effects of aging on naive T cell populations and diversity | 2019-09-26T00:00:00Z | Szeyi Ng | https://www.biomodels.org/BIOMD0000000824 | PMID:31201663 | "The human adaptive immune response is known to weaken in advanced age, resulting in increased sever(...TRUNCATED) | [
"Lewkiewics2019 - effects of aging on naive T cell populations and diversity.xml"
] | "<?xml version='1.0' encoding='UTF-8' standalone='no'?>\n<sbml xmlns=\"http://www.sbml.org/sbml/leve(...TRUNCATED) | pmid | NoPMCID | NoAbstract | "// Created by libAntimony v3.1.3\nmodel *New_Model()\n\n // Compartments and Species:\n compartme(...TRUNCATED) |
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