PMCID stringlengths 6 8 | title stringlengths 3 5.01k | abstract sequencelengths 0 102 | body sequencelengths 0 4.17k |
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8230954 | Multiplexed and High-throughput Label-Free Detection of RNA/Spike Protein/IgG/IgM Biomarkers of SARS-CoV-2 Infection Utilizing Nanoplasmonic Biosensors | [
"To tackle the COVID-19 outbreak, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is an unmet need for highly accurate diagnostic tests at all stages of infection with rapid results and unprecedentedly high specificity. Here, we present a label-free nanoplasmonic biosensor... | [] |
8197511 | Malignant Germ Cell Tumors and Their Precursor Gonadal Lesions in Patients with XY-DSD: A Case Series and Review of the Literature | [
"The risk of gonadal germ cell tumors is increased over the lifetime of patients with XY-disorders of sex development (XY-DSD). The aim of this study was to evaluate clinical features and histopathological outcome after gonadectomy in patients with XY-DSD to assess the risk of malignant transformation to gonadal ge... | [
"Disorders of sex development (DSD) are defined as congenital conditions with atypical gonadal, chromosomal, or anatomical sex. They usually present with atypical genitalia in the newborn or delayed puberty in the adolescent period .",
"According to the Chicago classification of DSD, patients are classified into ... |
8204445 | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease | [
"Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody stools. IBD is strongly associated with depression, and its patients have a higher incidence of depression th... | [
"Inflammatory bowel disease (IBD) is a group of chronic inflammatory autoimmune diseases that primarily affect the gastrointestinal tract. The main symptoms of IBD include abdominal pain, diarrhea, bloody stools, and mucus stools. In severe cases, malnutrition and intestinal perforation may occur. IBD primarily inc... |
8183214 | Challenge of food allergy testing and avoidance in children with atopic dermatitis | [
"Atopic dermatitis (AD) is a common presenting complaint by children and their caretakers to their primary care providers. On testing, children with AD frequently exhibit positive food-specific IgE levels in the absence of immediate allergic reactions. Misinterpretation of these false positive tests can lead to unn... | [] |
8313542 | Evaluation of S-RBD and high specificity ACE-2-binding antibodies on SARS-CoV-2 patients after six months from infection | [
"The antibody response to SARS-CoV-2 has not yet fully defined, but the availability of sensitive and specific serological assays is crucial to observe the presence of specific antibodies against the human receptor binding domain (S-RBD) and high specificity ACE-2-binding antibodies or neutralizing antibodies (NT) ... | [
"In the late December 2019, an outbreak of pneumonia caused by a novel human coronavirus (SARS-CoV-2) was reported in Wuhan, Hubei province, China [1]. The virus is highly pathogenic, and it is still spreading around the world, becoming a major public health concern. Specific and sensitive serological assays are ur... |
7935992 | Single-cell differential splicing analysis reveals high heterogeneity of liver tumor-infiltrating T cells | [
"Recent advances in single-cell RNA sequencing (scRNA-seq) have improved our understanding of the association between tumor-infiltrating lymphocyte (TILs) heterogeneity and cancer initiation and progression. However, studies investigating alternative splicing (AS) as an important regulatory factor of heterogeneity ... | [
"T cell heterogeneity in the tumor microenvironment (TME) is tightly linked to tumor progression, prognosis, and therapeutic efficacy. Systematic interrogation of tumor-infiltrating lymphocytes has been performed in liver, lung, colon and breast cancers using scRNA-seq. Effector and cytotoxic T cells can exert anti... |
8480024 | Targeting mutant p53 for cancer therapy: direct and indirect strategies | [
"TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 protein oncogenic properties. The p53-targeted therapy approach began with the identification of compounds capable of restoring/react... | [
"The tumor-suppressor p53, encoded by the TP53 gene (or Trp53 in mice), is critical for normal cell growth and tumor prevention . Generally, the p53 protein is kept at a low level in normal tissue by its negative regulator, mouse double minute 2/X (MDM2/X) . Numerous endogenous and exogenous stressors can activate ... |
8351668 | MicroRNA-106b-5p inhibits growth and progression of lung adenocarcinoma cells by downregulating IGSF10 | [
"In this study, we investigated the mechanistic role and prognostic significance of IGSF10 in lung adenocarcinoma. Oncomine database analysis showed that IGSF10 expression was significantly reduced in most cancer types, including lung adenocarcinoma (LUAD). In the TCGA-LUAD dataset, IGSF10 expression correlated pos... | [
"Lung cancer is the leading cause of tumor-related deaths worldwide . The two main types of lung cancer are non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), with NSCLC accounting for 85% of all lung cancer cases worldwide . Despite advances in treatment strategies in the recent years, the progn... |
8583926 | Evaluation of Therapeutic Targets in Histological Subtypes of Bladder Cancer | ["Histologically, bladder cancer is a heterogeneous group comprising urothelial carcinoma (UC), squa(...TRUNCATED) | ["Bladder cancer ranks as the tenth most common cancer worldwide . Accounting for more than 90% of a(...TRUNCATED) |
8259986 | "Rapid diagnosis and reduced workload for urinary tract infection using flowcytometry combined with (...TRUNCATED) | ["We evaluated if flowcytometry, using Sysmex UF-5000, could improve diagnosis of urinary tract infe(...TRUNCATED) | ["Urinary tract infections (UTI) are one of the most common bacterial infections with 50–60% lifet(...TRUNCATED) |
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