Task stringclasses 8
values | Measurement stringclasses 7
values |
|---|---|
identify genes that, upon being knocked out, would boost the efficacy of engineered T cells in the presence of an adenosine agonist that creates an immunosuppresive condition | the change in T cell proliferation |
Identify gene combinations that exhibit interactin effects (synergistic or buffering) on cell fitness in K562 cells upon combinatorial knockdown. An interaction effect should be determined by the deviation between the observed cell fitness and the expected fitness, which is calculated from the average impact of knockin... | The difference between the actual change in cell fitness and the expected additive effect from the individual knockdowns of the two genes. |
identify genes that regulate the production of Interferon-gamma (IFNG) | the log fold change in Interferon-gamma (IFNG) normalized read counts |
identify genes that regulate the production of Interleukin-2 (IL-2) | the log fold change in Interleukin-2 (IL-2) normalized read counts |
identify genes that, when knocked out, either increase or decrease expression of endogenous tau protein levels in neurons | the change in tau protein level compared to the non-targeting control, using a total tau antibody |
identify genes that, when knocked out, decrease expression of endogenous tau protein levels in neurons | the change in tau protein level compared to the non-targeting control, using a total tau antibody |
identify genes mediating lysosomal choline recycling using an endolysosome-focused CRISPR-Cas9 screen | enrichment or depletion of targeting sgRNAs (indicated by a high score) in the culture medium lacking free choline |
identify genes that upon activation allow cells to resist T-cell exhaustion, under the HA GD2 CAR (chimeric-antigenic receptor) condition | the log fold change in normalized sgRNA read counts compared to the non-targeting control, 22 days after perturbation |
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