Dataset Viewer
Auto-converted to Parquet Duplicate
query_id
stringlengths
1
4
query_text
stringlengths
27
502
genes
listlengths
1
22
documents
listlengths
1
9
docs
listlengths
1
9
query_gene_expansion
dict
1
A basic region in the tail is predicted to bind to acidic phospholipids in the plasma membrane.
[ { "gene_id": "DDB_G0289117", "gene_name": "myoB", "synonyms": "DMIB, abmB, myoIB, myosin-1B, myosin IB", "gene_products": "myosin IB heavy chain" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/24747353" ]
[ { "publication_id": 13954, "pmid": "24747353", "title": "The association of myosin IB with actin waves in dictyostelium requires both the plasma membrane-binding site and actin-binding region in the myosin tail.", "abstract_clean": "F-actin structures and their distribution are important determinant...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
10
A double mutant of gapA / rgaA IQGAP1 rgaA has a more severe chemotaxis defect and a more severe cytokinesis defect than either single mutant.
[ { "gene_id": "DDB_G0269140", "gene_name": "gapA", "synonyms": "iqgB, RasGAP, GAPA, DdIQGAP2, IQGAP-related protein, IQGAP2", "gene_products": "Ras GTPase-activating domain protein GapA" }, { "gene_id": "DDB_G0287585", "gene_name": "rgaA", "synonyms": "DG1029, iqgA, rasGAP, rasGAP1, D...
[ "http://www.ncbi.nlm.nih.gov/pubmed/20375144", "http://www.ncbi.nlm.nih.gov/pubmed/11447112" ]
[ { "publication_id": 48, "pmid": "20375144", "title": "Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis.", "abstract_clean": "In response to directional stimulation by a chemoattractant, cells rapidly activate a series of signaling pathways at the site closest to...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0269140", "DDB_G0287585" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
100
Although the Dictyostelium MLCK kinase has not been identified, rat calcium-calmodulin-dependent protein kinase kinase can be used as a surrogate activator of MLCK-A, phosphorylating it on Thr-166.
[ { "gene_id": "DDB_G0279925", "gene_name": "mlkA", "synonyms": "MLCK, MLCK-A, MLCKA", "gene_products": "myosin light chain kinase A" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/14570871" ]
[ { "publication_id": 1339, "pmid": "14570871", "title": "Regulatory mechanism of Dictyostelium myosin light chain kinase A.", "abstract_clean": "In this study, we examined the activation mechanism of Dictyostelium myosin light chain kinase A (MLCK-A) using constitutively active Ca2+/calmodulin-depend...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0279925" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1000
PIP3 negatively regulates Pten membrane localization, with mutual inhibition between PIP3 and PTEN leading to a a clear spatial separation between PIP3 and Pten on the membrane.
[ { "gene_id": "DDB_G0286557", "gene_name": "pten", "synonyms": "ptenA, protein tyrosine phosphatase, 3-phosphatidylinositol 3-phosphatase", "gene_products": "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/30367048" ]
[ { "publication_id": 18048, "pmid": "30367048", "title": "Mutual inhibition between PTEN and PIP3 generates bistability for polarity in motile cells.", "abstract_clean": "Phosphatidylinositol 3,4,5-trisphosphate (PIP3) and PIP3 phosphatase (PTEN) are enriched mutually exclusively on the anterior and ...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0286557" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1001
PIP5 kinase, PikI, produces PI4, 5P2 and is essential for efficient chemotaxis of Dictyostelium.
[ { "gene_id": "DDB_G0267588", "gene_name": "pikI", "synonyms": "PI5K", "gene_products": "phosphatidylinositol phosphate kinase PikI" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/24485835" ]
[ { "publication_id": 13782, "pmid": "24485835", "title": "A PIP5 kinase essential for efficient chemotactic signaling.", "abstract_clean": "In neutrophils and Dictyostelium, chemoattractant gradients generate directed cell migration by eliciting signaling events that bias intrinsic motility and favor...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0267588" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1002
pirA /AX2 null cells also have defects in cytokinesis and cell motility.
[ { "gene_id": "DDB_G0287855", "gene_name": "pirA", "synonyms": "PIR121", "gene_products": "SCAR regulatory complex subunit PirA" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/28889942" ]
[ { "publication_id": 16764, "pmid": "28889942", "title": "Differential functions of WAVE regulatory complex subunits in the regulation of actin-driven processes.", "abstract_clean": "The WAVE regulatory complex (WRC) links upstream Rho-family GTPase signaling to the activation of the ARP2/3 complex i...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0287855" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1003
PirA interacts with Rac GTPase rac1A, rac1B, rac1C and polarity regulator Leep1 leep1 Yang, et al 2021, PMID:33978708.
[ { "gene_id": "DDB_G0268622", "gene_name": "rac1B", "synonyms": "", "gene_products": "Rho GTPase Rac1B" }, { "gene_id": "DDB_G0277869", "gene_name": "rac1A", "synonyms": "", "gene_products": "Rho GTPase Rac1A" }, { "gene_id": "DDB_G0282365", "gene_name": "rac1C", "...
[ "http://www.ncbi.nlm.nih.gov/pubmed/30393033" ]
[ { "publication_id": 17890, "pmid": "30393033", "title": "Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo.", "abstract_clean": "Cell migration often involves the formation of sheet-like lamellipodia generated by branched actin filaments. The ...
{ "has_detectable_gene": "yes", "n_detected_genes": 5, "detected_gene_ids": [ "DDB_G0268622", "DDB_G0277869", "DDB_G0282365", "DDB_G0287855", "DDB_G0293920" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1004
pirA / napA double null phenotypes reveal that that NapA is required for pirA null phenotypes.
[ { "gene_id": "DDB_G0274519", "gene_name": "napA", "synonyms": "Nap125, Nap1", "gene_products": "SCAR regulatory complex subunit NapA" }, { "gene_id": "DDB_G0287855", "gene_name": "pirA", "synonyms": "PIR121", "gene_products": "SCAR regulatory complex subunit PirA" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/16581519" ]
[ { "publication_id": 981, "pmid": "16581519", "title": "Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways.", "abstract_clean": "SCAR--also known as WAVE--is a key regulator of actin dynamics. Activation of SCAR enhances the nucleation of new acti...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0274519", "DDB_G0287855" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1005
PKA is also part of the signal transduction pathway by which Prestarvation Factor PSF stimulates expression of carA carA-1, carA-2 and acaA at the initiation of development.
[ { "gene_id": "DDB_G0273397", "gene_name": "carA-1", "synonyms": "carA, carA1, cAR1, G-protein-coupled receptor", "gene_products": "cAMP receptor 1" }, { "gene_id": "DDB_G0273533", "gene_name": "carA-2", "synonyms": "carA, carA2, cAR1, G-protein-coupled receptor", "gene_products":...
[ "http://www.ncbi.nlm.nih.gov/pubmed/9584128" ]
[ { "publication_id": 3792, "pmid": "9584128", "title": "YakA, a protein kinase required for the transition from growth to development in Dictyostelium.", "abstract_clean": "When Dictyostelium cells starve they arrest their growth and induce the expression of genes necessary for development. We have i...
{ "has_detectable_gene": "yes", "n_detected_genes": 4, "detected_gene_ids": [ "DDB_G0273397", "DDB_G0273533", "DDB_G0281545", "DDB_G0289141" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1006
PKA pkaC, pkaR also mediates the response of several xenobiotic compounds, including valproic acid, a treatment for bipolar disorder, and curcumin.
[ { "gene_id": "DDB_G0279413", "gene_name": "pkaR", "synonyms": "PKA, rdeC, cAK", "gene_products": "cAMP-dependent protein kinase A, regulatory subunit" }, { "gene_id": "DDB_G0283907", "gene_name": "pkaC", "synonyms": "PKA, pkacat, DdPK3, DdPK2, PKA-C, PK2, PK3, cAK", "gene_product...
[ "http://www.ncbi.nlm.nih.gov/pubmed/16759735", "http://www.ncbi.nlm.nih.gov/pubmed/29135990" ]
[ { "publication_id": 869, "pmid": "16759735", "title": "The neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideum.", "abstract_clean": "Activation of the mitogen-activated protein kina...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0279413", "DDB_G0283907" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1007
PKA pkaC, pkaR plays a role in gradient sensing and chemotaxis to cAMP by regulating the Ras rasC, rasG, Rap1 and TORC2 signaling pathways in response to cAMP.
[ { "gene_id": "DDB_G0279413", "gene_name": "pkaR", "synonyms": "PKA, rdeC, cAK", "gene_products": "cAMP-dependent protein kinase A, regulatory subunit" }, { "gene_id": "DDB_G0281385", "gene_name": "rasC", "synonyms": "", "gene_products": "Ras GTPase RasC" }, { "gene_id": "...
[ "http://www.ncbi.nlm.nih.gov/pubmed/28302905" ]
[ { "publication_id": 16184, "pmid": "28302905", "title": "Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in <i>Dictyostelium</i>.", "abstract_clean": "Efficient directed migration requires tight regulation of chemoattractant signal transduction pat...
{ "has_detectable_gene": "yes", "n_detected_genes": 5, "detected_gene_ids": [ "DDB_G0279413", "DDB_G0281385", "DDB_G0283907", "DDB_G0291237", "DDB_G0293434" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1008
This protein kinase plays multiple roles throughout development.
[ { "gene_id": "DDB_G0283907", "gene_name": "pkaC", "synonyms": "PKA, pkacat, DdPK3, DdPK2, PKA-C, PK2, PK3, cAK", "gene_products": "cAMP-dependent protein kinase A, catalytic subunit" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/25872182", "http://www.ncbi.nlm.nih.gov/pubmed/9729606", "http://www.ncbi.nlm.nih.gov/pubmed/9126295", "http://www.ncbi.nlm.nih.gov/pubmed/1728597" ]
[ { "publication_id": 14624, "pmid": "25872182", "title": "Genetic control of morphogenesis in Dictyostelium.", "abstract_clean": "Cells grow, move, expand, shrink and die in the process of generating the characteristic shapes of organisms. Although the structures generated during development of the s...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1009
pkaR encodes the regulatory subunit of the cAMP dependent protein kinase PKA pkaC, pkaR.
[ { "gene_id": "DDB_G0279413", "gene_name": "pkaR", "synonyms": "PKA, rdeC, cAK", "gene_products": "cAMP-dependent protein kinase A, regulatory subunit" }, { "gene_id": "DDB_G0283907", "gene_name": "pkaC", "synonyms": "PKA, pkacat, DdPK3, DdPK2, PKA-C, PK2, PK3, cAK", "gene_product...
[ "http://www.ncbi.nlm.nih.gov/pubmed/1312226", "http://www.ncbi.nlm.nih.gov/pubmed/3467359" ]
[ { "publication_id": 5944, "pmid": "1312226", "title": "Mutation of protein kinase A causes heterochronic development of Dictyostelium.", "abstract_clean": "In heterochronic mutants the relative timing of developmental events is altered compared with the wild type. This generally results in a disorde...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0279413", "DDB_G0283907" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
101
Although the IQGAP-related protein DGAP1 rgaA binds to Rac1A, it does not affect its GTPase activity.
[ { "gene_id": "DDB_G0277869", "gene_name": "rac1A", "synonyms": "", "gene_products": "Rho GTPase Rac1A" }, { "gene_id": "DDB_G0287585", "gene_name": "rgaA", "synonyms": "DG1029, iqgA, rasGAP, rasGAP1, DGAP1, RIP2, IQGAP1", "gene_products": "Ras GTPase-activating-like protein rgaA"...
[ "http://www.ncbi.nlm.nih.gov/pubmed/9739079", "http://www.ncbi.nlm.nih.gov/pubmed/10825297" ]
[ { "publication_id": 3970, "pmid": "9739079", "title": "The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility.", "abstract_clean": "DGAP1 of Dictyostelium discoideum is a cell cortex associated 95 kDa protein that...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0277869", "DDB_G0287585" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1010
PKB also phosphorylates a Ras signaling complex that controls activation of RasC and its downstream target TORC2 in a negative feedback loop.
[ { "gene_id": "DDB_G0281385", "gene_name": "rasC", "synonyms": "", "gene_products": "Ras GTPase RasC" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/20493808" ]
[ { "publication_id": 112, "pmid": "20493808", "title": "A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration.", "abstract_clean": "Ras was found to regulate Dictyostelium chemotaxis, but the mechanisms that spatially and temporally control Ras activity during chemotaxis...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0281385" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1011
PKB and PKBR1 phosphorylate Sca1 and regulate the membrane localization of the Sca1 complex, and thereby RasC activity, in a negative feedback fashion.
[ { "gene_id": "DDB_G0277843", "gene_name": "scaA", "synonyms": "DG1105, Sca1, armadillo-like helical domain-containing protein", "gene_products": "Sca1 complex scaffold protein" }, { "gene_id": "DDB_G0281385", "gene_name": "rasC", "synonyms": "", "gene_products": "Ras GTPase RasC"...
[ "http://www.ncbi.nlm.nih.gov/pubmed/20493808" ]
[ { "publication_id": 112, "pmid": "20493808", "title": "A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration.", "abstract_clean": "Ras was found to regulate Dictyostelium chemotaxis, but the mechanisms that spatially and temporally control Ras activity during chemotaxis...
{ "has_detectable_gene": "yes", "n_detected_genes": 3, "detected_gene_ids": [ "DDB_G0277843", "DDB_G0281385", "DDB_G0290157" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1012
PKB can bind to PIP2 and PIP3 through its N-terminal PH-domain and become localized to the membrane at the front of migrating cells.
[ { "gene_id": "DDB_G0268620", "gene_name": "pkbA", "synonyms": "Akt, PKB, pkfC, DK1, AktPKB", "gene_products": "AKT/PKB protein kinase PkbA" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/11553719", "http://www.ncbi.nlm.nih.gov/pubmed/15534002", "http://www.ncbi.nlm.nih.gov/pubmed/15352238", "http://www.ncbi.nlm.nih.gov/pubmed/10192918" ]
[ { "publication_id": 2428, "pmid": "11553719", "title": "Sequential activities of phosphoinositide 3-kinase, PKB/Aakt, and Rab7 during macropinosome formation in Dictyostelium.", "abstract_clean": "Macropinocytosis plays an important role in the internalization of antigens by dendritic cells and is t...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1013
PKB localizes persistantly at the front when cell-cell contacts are formed.
[ { "gene_id": "DDB_G0268620", "gene_name": "pkbA", "synonyms": "Akt, PKB, pkfC, DK1, AktPKB", "gene_products": "AKT/PKB protein kinase PkbA" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/10205164" ]
[ { "publication_id": 3520, "pmid": "10205164", "title": "Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium.", "abstract_clean": "Chemotaxis-competent cells respond to a variety of ligands by activating seco...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1014
PKB phosphorylates serines and threonines in many different proteins including PakA, pakA, PikI, pikI, talinB, talB, GefN, gefN, GacG gacG and triggers polymerization of dendritic actin at the leading edge.
[ { "gene_id": "DDB_G0267588", "gene_name": "pikI", "synonyms": "PI5K", "gene_products": "phosphatidylinositol phosphate kinase PikI" }, { "gene_id": "DDB_G0269166", "gene_name": "pakA", "synonyms": "dpak1, DPAKa", "gene_products": "serine/threonine-protein kinase PakA" }, { ...
[ "http://www.ncbi.nlm.nih.gov/pubmed/11389841", "http://www.ncbi.nlm.nih.gov/pubmed/18452713", "http://www.ncbi.nlm.nih.gov/pubmed/18635356" ]
[ { "publication_id": 2403, "pmid": "11389841", "title": "Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa.", "abstract_clean": "We demonstrate that PI3 kinase and protein kinase B (PKB or Akt) control cell polarity and chemotaxis, in part, through the r...
{ "has_detectable_gene": "yes", "n_detected_genes": 5, "detected_gene_ids": [ "DDB_G0267588", "DDB_G0269166", "DDB_G0275703", "DDB_G0283955", "DDB_G0287505" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1015
pkbA encodes the homolog of the protein kinase B made by the oncogene Akt.
[ { "gene_id": "DDB_G0268620", "gene_name": "pkbA", "synonyms": "Akt, PKB, pkfC, DK1, AktPKB", "gene_products": "AKT/PKB protein kinase PkbA" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/10192918", "http://www.ncbi.nlm.nih.gov/pubmed/10205164" ]
[ { "publication_id": 3447, "pmid": "10192918", "title": "Identification of protein kinase B (PKB) as a phosphatidylinositol 3,4,5-trisphosphate binding protein in Dictyostelium discoideum.", "abstract_clean": "We have searched for phosphatidylinositol (PI)-3,4,5-trisphosphate (PIP3) binding proteins ...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0268620" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1016
PkbR1 plays a role in the signal transduction pathway by which GABA induces release of the SDF-2 precursor AcbA acbA during culmination.
[ { "gene_id": "DDB_G0270658", "gene_name": "acbA", "synonyms": "", "gene_products": "acyl-CoA binding protein AcbA" }, { "gene_id": "DDB_G0290157", "gene_name": "pkgB", "synonyms": "pkfA, pkbR1, PK2, DK2, PKBR-1, protein kinase 2, Dd kinase 2", "gene_products": "SGK family protein...
[ "http://www.ncbi.nlm.nih.gov/pubmed/16672332" ]
[ { "publication_id": 848, "pmid": "16672332", "title": "GABA induces terminal differentiation of Dictyostelium through a GABAB receptor.", "abstract_clean": "When prespore cells approach the top of the stalk in a Dictyostelium fruiting body, they rapidly encapsulate in response to the signalling pept...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0270658", "DDB_G0290157" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1017
The protein kinase pkcA pkcA positively regulates phospholipase D activity, and PkcA and PldB functionally interact to regulate aggregation, differentiation, and cell-cell adhesion during development..
[ { "gene_id": "DDB_G0279483", "gene_name": "pldB", "synonyms": "PLD1", "gene_products": "phospholipase D1" }, { "gene_id": "DDB_G0288147", "gene_name": "pkcA", "synonyms": "", "gene_products": "protein kinase PkcA" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/28257811" ]
[ { "publication_id": 16144, "pmid": "28257811", "title": "Functional interaction of PkcA and PldB regulate aggregation and development in Dictyostelium discoideum.", "abstract_clean": "Multicellular development in Dictyostelium discoideum involves tightly regulated signaling events controlling the en...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0279483", "DDB_G0288147" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1018
pkgB null mutants arrest at the mound stage but this block can be suppressed by over expression of PKB.
[ { "gene_id": "DDB_G0290157", "gene_name": "pkgB", "synonyms": "pkfA, pkbR1, PK2, DK2, PKBR-1, protein kinase 2, Dd kinase 2", "gene_products": "SGK family protein kinase PkgB" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/10873800", "http://www.ncbi.nlm.nih.gov/pubmed/21335531" ]
[ { "publication_id": 3074, "pmid": "10873800", "title": "A novel Akt/PKB-related kinase is essential for morphogenesis in Dictyostelium.", "abstract_clean": "Background\nDictyostelium Akt/PKB is homologous to mammalian Akt/PKB and is required for cell polarity and proper chemotaxis during early devel...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0290157" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1019
PKS16 pks16 and PKS17 are highly similar and form a phylogenetic clade distinct from other polyketide synthase genes.
[ { "gene_id": "DDB_G0275069", "gene_name": "pks16", "synonyms": "dipks16, FAS, beta-ketoacyl synthase family protein", "gene_products": "putative fatty acid synthase 16" }, { "gene_id": "DDB_G0275077", "gene_name": "pks17", "synonyms": "dipks17, FAS, beta-ketoacyl synthase family prot...
[ "http://www.ncbi.nlm.nih.gov/pubmed/17660200" ]
[ { "publication_id": 724, "pmid": "17660200", "title": "Polyketide synthase genes and the natural products potential of Dictyostelium discoideum.", "abstract_clean": "Motivation\nThe genome of the social amoeba Dictyostelium discoideum contains an unusually large number of polyketide synthase (PKS) g...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0275069", "DDB_G0275077" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
102
Although tirA null cells grow normally in liquid media and on heat-killed bacteria, they only form minute colonies on bacterial lawns, suggesting that TirA is required during vegetative foraging.
[ { "gene_id": "DDB_G0289237", "gene_name": "tirA", "synonyms": "", "gene_products": "Toll-Interleukin (TIR) receptor domain-containing protein" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/17673666" ]
[ { "publication_id": 707, "pmid": "17673666", "title": "Immune-like phagocyte activity in the social amoeba.", "abstract_clean": "Social amoebae feed on bacteria in the soil but aggregate when starved to form a migrating slug. We describe a previously unknown cell type in the social amoeba, which app...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0289237" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1020
pks16 is enriched in gametes, but when tested for growth in HL5, fruiting body formation, sexual cell fusion and zygote development a pks16 RNAi mutant displayed a wild type phenotype.
[ { "gene_id": "DDB_G0275069", "gene_name": "pks16", "synonyms": "dipks16, FAS, beta-ketoacyl synthase family protein", "gene_products": "putative fatty acid synthase 16" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/15817229", "http://www.ncbi.nlm.nih.gov/pubmed/12963116" ]
[ { "publication_id": 1228, "pmid": "15817229", "title": "Reverse genetic analyses of gamete-enriched genes revealed a novel regulator of the cAMP signaling pathway in Dictyostelium discoideum.", "abstract_clean": "Sexual development in Dictyostelium discoideum is initiated by the fusion of opposite m...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0275069" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1021
Plant lectins induce the same response, suggesting that modified uptake and persistence of lectin-coated bacteria in eukaryotic cells is a general phenomenon, termed lectin-induced modified bacterial internalization.
[ { "gene_id": "DDB_G0273063", "gene_name": "dscA-1", "synonyms": "dscA, discoidin I, A chain", "gene_products": "discoidin I, alpha chain" }, { "gene_id": "DDB_G0273065", "gene_name": "dscC-1", "synonyms": "dscC, dscB, discoidin I, C chain and B chain, discoidin I, beta chain, discoid...
[ "http://www.ncbi.nlm.nih.gov/pubmed/30049880" ]
[ { "publication_id": 17611, "pmid": "30049880", "title": "Lectins modulate the microbiota of social amoebae.", "abstract_clean": "The social amoeba Dictyostelium discoideum maintains a microbiome during multicellular development; bacteria are carried in migrating slugs and as endosymbionts within amo...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1022
PldB and paxB functionally interact to regulate the organization of the actin cytoskeleton.
[ { "gene_id": "DDB_G0274109", "gene_name": "paxB", "synonyms": "", "gene_products": "paxillin" }, { "gene_id": "DDB_G0279483", "gene_name": "pldB", "synonyms": "PLD1", "gene_products": "phospholipase D1" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/21531871" ]
[ { "publication_id": 11361, "pmid": "21531871", "title": "Paxillin and phospholipase D interact to regulate actin-based processes in Dictyostelium discoideum.", "abstract_clean": "The actin cytoskeleton forms a membrane-associated network whose proper regulation is essential for numerous processes, i...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0274109", "DDB_G0279483" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1023
PldB regulates chemotaxis and cell sorting, and was also found to mediate CMF-dependent quorum sensing by regulating G protein signaling.
[ { "gene_id": "DDB_G0279483", "gene_name": "pldB", "synonyms": "PLD1", "gene_products": "phospholipase D1" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/20950684" ]
[ { "publication_id": 17, "pmid": "20950684", "title": "Phospholipase D controls Dictyostelium development by regulating G protein signaling.", "abstract_clean": "Dictyostelium discoideum cells normally exist as individual amoebae, but will enter a period of multicellular development upon starvation. ...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0279483" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1024
pneumoniae is due to a defective sensing of ingested bacteria and that sensing of folate is required to ensure rapid intracellular killing.
[ { "gene_id": "DDB_G0287055", "gene_name": "vps13F", "synonyms": "", "gene_products": "vacuolar protein sorting-associated protein 13 family protein F" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/28076662" ]
[ { "publication_id": 15984, "pmid": "28076662", "title": "Vps13F links bacterial recognition and intracellular killing in Dictyostelium.", "abstract_clean": "Bacterial sensing, ingestion, and killing by phagocytic cells are essential processes to protect the human body from infectious microorganisms....
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1025
pneumophila by remodeling the ER connecting with the pathogen vacuole.
[ { "gene_id": "DDB_G0279823", "gene_name": "sey1", "synonyms": "atl3, SEY1 protein", "gene_products": "atlastin" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/28835546" ]
[ { "publication_id": 16684, "pmid": "28835546", "title": "ER remodeling by the large GTPase atlastin promotes vacuolar growth of <i>Legionella pneumophila</i>.", "abstract_clean": "The pathogenic bacterium Legionella pneumophila replicates in host cells within a distinct ER-associated compartment ter...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1026
pneumophila growth is reduced by approximately 25% compared to growth in wt.
[ { "gene_id": "DDB_G0289173", "gene_name": "arfA", "synonyms": "ARF1, Arf GTPase ArfA", "gene_products": "ADP-ribosylation factor A" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/25189617" ]
[ { "publication_id": 14201, "pmid": "25189617", "title": "Defective lysosome maturation and Legionella pneumophila replication in Dictyostelium cells mutant for the Arf GAP ACAP-A.", "abstract_clean": "Dictyostelium discoideum ACAP-A is an Arf GTPase-activating protein (GAP) involved in cytokinesis, ...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1027
Poly ADP-ribose polymers promote NHEJ by binding Ku70 at DSBs and attaching Ku80.
[ { "gene_id": "DDB_G0286069", "gene_name": "ku70", "synonyms": "ATP-dependent DNA helicase ku70", "gene_products": "ATP-dependent DNA helicase 2 subunit ku70" }, { "gene_id": "DDB_G0286303", "gene_name": "ku80", "synonyms": "", "gene_products": "ATP-dependent DNA helicase 2 subuni...
[ "http://www.ncbi.nlm.nih.gov/pubmed/21807880" ]
[ { "publication_id": 11603, "pmid": "21807880", "title": "PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks.", "abstract_clean": "Poly adenosine diphosphate (ADP)-ribosylation (PARylation) by poly ADP-ribose (PAR) polymerases (PARPs) is an early response to DNA ...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0286069", "DDB_G0286303" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1028
Polymerization of alpha/beta heterodimers is initiated at the MicroTubule Organizing Center MTOC and extends in the plus end direction to the periphery of the cell where the microtubules can couple to the actin cortex and make rapid sweeping movements across the whole cell.
[ { "gene_id": "DDB_G0287689", "gene_name": "tubA", "synonyms": "tubA1, tubulin alpha chain, alpha tubulin", "gene_products": "alpha-tubulin A" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/15527790", "http://www.ncbi.nlm.nih.gov/pubmed/16942924" ]
[ { "publication_id": 1432, "pmid": "15527790", "title": "A brilliant monomeric red fluorescent protein to visualize cytoskeleton dynamics in Dictyostelium.", "abstract_clean": "Red fluorescent proteins (RFPs) combined with GFP are attractive probes for double-fluorescence labeling of proteins in live...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1029
ponA encodes ponticulin A, a small, atypical membrane protein with both an N-terminal transmembrane domain and a C-terminal glycosylphosphatidylinositol GPI anchor.
[ { "gene_id": "DDB_G0293522", "gene_name": "ponA", "synonyms": "gp17, actin binding protein", "gene_products": "ponticulin A" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/8089175" ]
[ { "publication_id": 5344, "pmid": "8089175", "title": "Ponticulin is an atypical membrane protein.", "abstract_clean": "We have cloned and sequenced ponticulin, a 17,000-dalton integral membrane glycoprotein that binds F-actin and nucleates actin assembly. A single copy gene encodes a developmentall...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0293522" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
103
Although uptake of the intercellular pathogen Legionella pneumophila is reduced 8 fold, those bacteria that get into the atg9 - mutant cells are more successful in establishing a replicative niche and replicating.
[ { "gene_id": "DDB_G0285323", "gene_name": "atg9", "synonyms": "APG9", "gene_products": "autophagy protein 9" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/20070309" ]
[ { "publication_id": 40, "pmid": "20070309", "title": "Loss of Dictyostelium ATG9 results in a pleiotropic phenotype affecting growth, development, phagocytosis and clearance and replication of Legionella pneumophila.", "abstract_clean": "Infection of Dictyostelium discoideum with Legionella pneumoph...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0285323" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1030
ponA null cells precociously aggregate into mounds but exhibit a delay in the completion of development suggesting that ponticulin plays a role in the temporal regulation of both the early and late stages of development.
[ { "gene_id": "DDB_G0293522", "gene_name": "ponA", "synonyms": "gp17, actin binding protein", "gene_products": "ponticulin A" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/8089176" ]
[ { "publication_id": 5381, "pmid": "8089176", "title": "Ponticulin is the major high affinity link between the plasma membrane and the cortical actin network in Dictyostelium.", "abstract_clean": "Interactions between the plasma membrane and underlying actin-based cortex have been implicated in membr...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0293522" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1031
Ponticulin specifically binds F-actin, and is required for actin nucleation.
[ { "gene_id": "DDB_G0293522", "gene_name": "ponA", "synonyms": "gp17, actin binding protein", "gene_products": "ponticulin A" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/8432731", "http://www.ncbi.nlm.nih.gov/pubmed/2307703", "http://www.ncbi.nlm.nih.gov/pubmed/2060029", "http://www.ncbi.nlm.nih.gov/pubmed/3312238" ]
[ { "publication_id": 5467, "pmid": "8432731", "title": "The integral membrane protein, ponticulin, acts as a monomer in nucleating actin assembly.", "abstract_clean": "Ponticulin, an F-actin binding transmembrane glycoprotein in Dictyostelium plasma membranes, was isolated by detergent extraction fro...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1032
present evidence that, in addition to cGMP signaling, intracellular Ca2+ is a parallel second messenger involved in STATc regulation.
[ { "gene_id": "DDB_G0293532", "gene_name": "dstC", "synonyms": "STATc, Dd-STATc, transcriptional repressor", "gene_products": "signal transducer and activator of transcription (STAT) family protein DstC" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/20159963" ]
[ { "publication_id": 246, "pmid": "20159963", "title": "Dual regulation of a Dictyostelium STAT by cGMP and Ca2+ signalling.", "abstract_clean": "When cells are exposed to hyperosmotic stress, the Dictyostelium STAT orthologue STATc is rapidly tyrosine phosphorylated. Previous observations suggest a ...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0293532" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1033
proC is expressed in vegetative cells as well as during early development giving a peak of mRNA abundance at T=11 hrs but the abundance is much lower than for the mRNA of proA or proB.
[ { "gene_id": "DDB_G0271142", "gene_name": "proC", "synonyms": "p3", "gene_products": "profilin III" }, { "gene_id": "DDB_G0286187", "gene_name": "proB", "synonyms": "", "gene_products": "profilin II" }, { "gene_id": "DDB_G0287125", "gene_name": "proA", "synonyms":...
[ "http://www.ncbi.nlm.nih.gov/pubmed/25887420" ]
[ { "publication_id": 14621, "pmid": "25887420", "title": "Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum.", "abstract_clean": "Background\nDevelopment of the soil amoeba Dictyostelium discoideum is triggered by starvation. When placed on a solid substrate, the starving...
{ "has_detectable_gene": "yes", "n_detected_genes": 3, "detected_gene_ids": [ "DDB_G0271142", "DDB_G0286187", "DDB_G0287125" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1034
Protein kinase B AKT pkbA is a putative upstream inhibitor of TSC2, suggesting that AKT, TSC2 and Rheb function coordinately to regulate signal transduction during phagocytosis.
[ { "gene_id": "DDB_G0268620", "gene_name": "pkbA", "synonyms": "Akt, PKB, pkfC, DK1, AktPKB", "gene_products": "AKT/PKB protein kinase PkbA" }, { "gene_id": "DDB_G0277041", "gene_name": "rheb", "synonyms": "GTP-binding protein Rheb", "gene_products": "Ras GTPase RheB" }, { ...
[ "http://www.ncbi.nlm.nih.gov/pubmed/22266904" ]
[ { "publication_id": 11991, "pmid": "22266904", "title": "TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing.", "abstract_clean": "The TOR protein kinase functions in two distinct complexes, TOR complex 1 (TORC1) and 2 (TORC2...
{ "has_detectable_gene": "yes", "n_detected_genes": 3, "detected_gene_ids": [ "DDB_G0268620", "DDB_G0277041", "DDB_G0280527" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1035
Protein-tyrosine kinase genes were recognized by screening cDNA expression libraries with anti-phosphotyrosine antibody.
[ { "gene_id": "DDB_G0283385", "gene_name": "splA", "synonyms": "pyk1, DPYK1", "gene_products": "dual-specificity protein kinase SplA" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/1972546", "http://www.ncbi.nlm.nih.gov/pubmed/8898113" ]
[ { "publication_id": 6479, "pmid": "1972546", "title": "Developmentally regulated protein-tyrosine kinase genes in Dictyostelium discoideum.", "abstract_clean": "Dictyostelium discoideum, an organism that undergoes development and that is amenable to biochemical and molecular genetic approaches, is a...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1036
Proteomic analyses reveal that NxnA also localizes to the phagosome and to Legionella-containing phagosomes.
[ { "gene_id": "DDB_G0269160", "gene_name": "nxnA", "synonyms": "ANN7, DdANN7, synexin, quit3, annexin C1", "gene_products": "annexin VII" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/19482547" ]
[ { "publication_id": 304, "pmid": "19482547", "title": "Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium.", "abstract_clean": "Legionella pneumophila, the agent of Legionnaires' disease, replicates intracellularly within specialized phagosomes of human macrophages an...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0269160" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1037
Proteomic analysis reveals that ArfA also localizes to the phagosome and the Legionella-containing vacuole LCV, and mammalian orthologs of ArfA are involved in the formation of the LCV.
[ { "gene_id": "DDB_G0289173", "gene_name": "arfA", "synonyms": "ARF1, Arf GTPase ArfA", "gene_products": "ADP-ribosylation factor A" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/18980612", "http://www.ncbi.nlm.nih.gov/pubmed/16926386" ]
[ { "publication_id": 275, "pmid": "18980612", "title": "Proteome analysis of Legionella vacuoles purified by magnetic immunoseparation reveals secretory and endosomal GTPases.", "abstract_clean": "Legionella pneumophila, the causative agent of Legionnaires' disease, replicates in macrophages and amoe...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0289173" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1038
Protovillin interacts with the calcium-binding protein CbpA cbpA in a Ca2+-independent manner, suggesting that CbpA might associate with protovillin to enable Ca2+ regulation of protovillin.
[ { "gene_id": "DDB_G0276759", "gene_name": "cbpA", "synonyms": "CBP1", "gene_products": "calcium-binding protein" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/10896781" ]
[ { "publication_id": 3142, "pmid": "10896781", "title": "CBP1 associates with the Dictyostelium cytoskeleton and is important for normal cell aggregation under certain developmental conditions.", "abstract_clean": "In cells of the eukaryotic microorganism Dictyostelium discoideum, at least eight smal...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0276759" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1039
Protovillin lacks actin filament severing activity and does not nucleate actin polymerization but binds to monomeric actin.
[ { "gene_id": "DDB_G0276453", "gene_name": "vilB", "synonyms": "Cap100, F-actin capping protein", "gene_products": "protovillin" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/1333365" ]
[ { "publication_id": 5888, "pmid": "1333365", "title": "Cap100, a novel phosphatidylinositol 4,5-bisphosphate-regulated protein that caps actin filaments but does not nucleate actin assembly.", "abstract_clean": "The fast and transient polymerization of actin in nonmuscle cells after stimulation with...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
104
AlyL, a putative lysozyme seems to fit this role as it is expressed during and required for growth on Gram-negative bacteria.
[ { "gene_id": "DDB_G0286229", "gene_name": "alyL", "synonyms": "", "gene_products": "amoeba-type lysozyme L" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/23664307" ]
[ { "publication_id": 13218, "pmid": "23664307", "title": "Bacterial discrimination by dictyostelid amoebae reveals the complexity of ancient interspecies interactions.", "abstract_clean": "Background\nAmoebae and bacteria interact within predator-prey and host-pathogen relationships, but the general ...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0286229" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1040
PsaA directly interacts with Cdk5 in the nucleus, while Cdk5 and PsaA have been shown to co-immunoprecipitated with nuclear calmodulin.
[ { "gene_id": "DDB_G0270994", "gene_name": "psaA", "synonyms": "psA", "gene_products": "puromycin-sensitive aminopeptidase PsaA" }, { "gene_id": "DDB_G0288677", "gene_name": "cdk5", "synonyms": "crp, crpA", "gene_products": "cyclin-dependent kinase 5" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/23063531", "http://www.ncbi.nlm.nih.gov/pubmed/21766205" ]
[ { "publication_id": 12722, "pmid": "23063531", "title": "Cyclin-dependent kinase 5 is a calmodulin-binding protein that associates with puromycin-sensitive aminopeptidase in the nucleus of Dictyostelium.", "abstract_clean": "Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that has been...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0270994", "DDB_G0288677" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1041
PSF activates the protein kinase YakA yakA such that it inhibits PufA pufA which is the translational inhibitor of pkaC.
[ { "gene_id": "DDB_G0279735", "gene_name": "pufA", "synonyms": "", "gene_products": "RNA-binding protein PufA" }, { "gene_id": "DDB_G0283605", "gene_name": "yakA", "synonyms": "dagB", "gene_products": "DYRK family protein kinase YakA" }, { "gene_id": "DDB_G0283907", "g...
[ "http://www.ncbi.nlm.nih.gov/pubmed/10375515" ]
[ { "publication_id": 3334, "pmid": "10375515", "title": "Starvation promotes Dictyostelium development by relieving PufA inhibition of PKA translation through the YakA kinase pathway.", "abstract_clean": "When nutrients are depleted, Dictyostelium cells undergo cell cycle arrest and initiate a develo...
{ "has_detectable_gene": "yes", "n_detected_genes": 3, "detected_gene_ids": [ "DDB_G0279735", "DDB_G0283605", "DDB_G0283907" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1042
psiA knockout mutant strains develop normally, however, conditioned medium from these mutants shows reduced prespore-cell-inducing activity and reduced prespore cell division-inducing activity, suggesting that PsiA plays a role in the positive regulation of spore cell differentiation.
[ { "gene_id": "DDB_G0291982", "gene_name": "psiA", "synonyms": "PA14 domain-containing protein, psi factor", "gene_products": "prespore-cell-inducing factor" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/15367206" ]
[ { "publication_id": 1343, "pmid": "15367206", "title": "A gene encoding, prespore-cell-inducing factor in Dictyostelium discoideum.", "abstract_clean": "Two factors that exist in conditioned medium (CM) of Dictyostelium discoideum induce amoebae to differentiate into prespore cells when they are inc...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0291982" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1043
pspA encodes the prespore specific SP29 protein that is recognized by the monoclonal antibody MUD1.
[ { "gene_id": "DDB_G0267412", "gene_name": "pspA", "synonyms": "D19, psA, SP29, ponG, ponticulin-related protein", "gene_products": "cell surface glycoprotein PsA precursor" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/3837179", "http://www.ncbi.nlm.nih.gov/pubmed/2850494", "http://www.ncbi.nlm.nih.gov/pubmed/6724136" ]
[ { "publication_id": 7796, "pmid": "3837179", "title": "A polymorphic, prespore-specific cell surface glycoprotein is present in the extracellular matrix of Dictyostelium discoideum.", "abstract_clean": "Polymorphisms of a major developmentally regulated prespore-specific protein (PsA) in Dictyosteli...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0267412" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1044
PspA is a cell surface protein carrying a modB gnt2 dependent O-linked oligosaccharide.
[ { "gene_id": "DDB_G0267412", "gene_name": "pspA", "synonyms": "D19, psA, SP29, ponG, ponticulin-related protein", "gene_products": "cell surface glycoprotein PsA precursor" }, { "gene_id": "DDB_G0291241", "gene_name": "gnt2", "synonyms": "modB, gntB, cis4c, GlcNAc transferase, polype...
[ "http://www.ncbi.nlm.nih.gov/pubmed/3902823" ]
[ { "publication_id": 7930, "pmid": "3902823", "title": "Absence of a carbohydrate modification does not affect the level or subcellular localization of three membrane glycoproteins in modB mutants of Dictyostelium discoideum.", "abstract_clean": "The accumulation and localization of four developmenta...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0267412", "DDB_G0291241" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1045
psvA encodes the spore coat protein SP35 that is stored in prespore vesicles and released during sporulation such that it can bind cellulose to help form the middle of the trilaminar surface layer.
[ { "gene_id": "DDB_G0276869", "gene_name": "psvA", "synonyms": "EB4, SP35", "gene_products": "prespore vesicle protein" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/9692967", "http://www.ncbi.nlm.nih.gov/pubmed/2049876" ]
[ { "publication_id": 3755, "pmid": "9692967", "title": "Two proteins of the Dictyostelium spore coat bind to cellulose in vitro.", "abstract_clean": "The spore coat of Dictyostelium contains nine different proteins and cellulose. Interactions between protein and cellulose were investigated using an i...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0276869" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "no" }
1046
pspB mRNA accumulates to much higher levels in cells lacking the cAMP receptor CAR2 carB.
[ { "gene_id": "DDB_G0276939", "gene_name": "pspB", "synonyms": "psB, 14E6, 14E-6, prespore protein", "gene_products": "spore coat protein SP85" }, { "gene_id": "DDB_G0288179", "gene_name": "carB", "synonyms": "cAR2", "gene_products": "cAMP receptor 2" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/8436297" ]
[ { "publication_id": 5568, "pmid": "8436297", "title": "CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum.", "abstract_clean": "Extracellular cAMP serves as a primary signaling molecule to regulate the development of Dictyostelium discoi...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0276939", "DDB_G0288179" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1047
PTEN binds to PIP2 in the membrane to position itself near its substrate.
[ { "gene_id": "DDB_G0286557", "gene_name": "pten", "synonyms": "ptenA, protein tyrosine phosphatase, 3-phosphatidylinositol 3-phosphatase", "gene_products": "phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/25448479" ]
[ { "publication_id": 14370, "pmid": "25448479", "title": "Engineering PTEN function: membrane association and activity.", "abstract_clean": "Many tumors are associated with deficiency of the tumor suppressor, PTEN, a PIP3 phosphatase that turns off PIP3 signaling. The major site of PTEN action is the...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0286557" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1048
PTP3 is expressed in anterior-like and prestalk cell types..
[ { "gene_id": "DDB_G0282145", "gene_name": "ptpC", "synonyms": "PTP3, phosphotyrosine phosphatase, tyrosine-protein phosphatase", "gene_products": "protein tyrosine phosphatase 3" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/1423620" ]
[ { "publication_id": 5848, "pmid": "1423620", "title": "Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium.", "abstract_clean": "We have cloned a Dictyostelium phosphotyrosine phosphatase (PTP1) with a catalyt...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0282145" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1049
PufA binds to a 200 base segment in 3' untranslated regions of pkaC pkaC mRNA and inhibits translation. The pufA gene was isolated in a suppressor screen of yakA null mutants that are unable to initiate development.
[ { "gene_id": "DDB_G0279735", "gene_name": "pufA", "synonyms": "", "gene_products": "RNA-binding protein PufA" }, { "gene_id": "DDB_G0283605", "gene_name": "yakA", "synonyms": "dagB", "gene_products": "DYRK family protein kinase YakA" }, { "gene_id": "DDB_G0283907", "g...
[ "http://www.ncbi.nlm.nih.gov/pubmed/10375515" ]
[ { "publication_id": 3334, "pmid": "10375515", "title": "Starvation promotes Dictyostelium development by relieving PufA inhibition of PKA translation through the YakA kinase pathway.", "abstract_clean": "When nutrients are depleted, Dictyostelium cells undergo cell cycle arrest and initiate a develo...
{ "has_detectable_gene": "yes", "n_detected_genes": 3, "detected_gene_ids": [ "DDB_G0279735", "DDB_G0283605", "DDB_G0283907" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
105
AmiB is thought to play a role early in development by stimulating acaA expression which is essential for cAMP signaling intracellular signaling cascade.
[ { "gene_id": "DDB_G0281545", "gene_name": "acaA", "synonyms": "adenylyl cyclase, ACA", "gene_products": "adenylate cyclase A" }, { "gene_id": "DDB_G0282375", "gene_name": "amiB", "synonyms": "med13", "gene_products": "putative mediator complex subunit 13" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/10651904" ]
[ { "publication_id": 3089, "pmid": "10651904", "title": "amiB, a novel gene required for the growth/differentiation transition in Dictyostelium.", "abstract_clean": "Background\nThe differentiation programme of Dictyostelium discoideum is initiated by starvation. Nutrient depletion triggers the diffe...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0281545", "DDB_G0282375" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1050
Putative endocytic signals have been identified in p80.
[ { "gene_id": "DDB_G0287297", "gene_name": "p80", "synonyms": "endosomal membrane protein", "gene_products": "putative copper transporter p80" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/11831389" ]
[ { "publication_id": 2632, "pmid": "11831389", "title": "Membrane sorting in the endocytic and phagocytic pathway of Dictyostelium discoideum.", "abstract_clean": "To study sorting in the endocytic pathway of a phagocytic and macropinocytic cell, monoclonal antibodies to membrane proteins of Dictyost...
{ "has_detectable_gene": "no", "n_detected_genes": 0, "detected_gene_ids": [], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1051
Putative transcriptional targets of STATc during the hyperosmotic response have been identified: rtoA, gapA, sevA, rgaA, racI.
[ { "gene_id": "DDB_G0269140", "gene_name": "gapA", "synonyms": "iqgB, RasGAP, GAPA, DdIQGAP2, IQGAP-related protein, IQGAP2", "gene_products": "Ras GTPase-activating domain protein GapA" }, { "gene_id": "DDB_G0271916", "gene_name": "rtoA", "synonyms": "RatioA", "gene_products": "u...
[ "http://www.ncbi.nlm.nih.gov/pubmed/12771188", "http://www.ncbi.nlm.nih.gov/pubmed/17517120" ]
[ { "publication_id": 1626, "pmid": "12771188", "title": "A STAT-regulated, stress-induced signalling pathway in Dictyostelium.", "abstract_clean": "The Dictyostelium stalk cell inducer differentiation-inducing factor (DIF) directs tyrosine phosphorylation and nuclear accumulation of the STAT (signal ...
{ "has_detectable_gene": "yes", "n_detected_genes": 6, "detected_gene_ids": [ "DDB_G0269140", "DDB_G0271916", "DDB_G0277897", "DDB_G0287585", "DDB_G0289327", "DDB_G0293532" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1052
rab14 is expressed at a relatively constant level throughout growth and development and is associated with the lysosomal membrane and the contractile vacuole complex.
[ { "gene_id": "DDB_G0281337", "gene_name": "rab14", "synonyms": "rab4, rabD", "gene_products": "Rab GTPase 14" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/7929276", "http://www.ncbi.nlm.nih.gov/pubmed/7876348" ]
[ { "publication_id": 5299, "pmid": "7929276", "title": "Characterization of lysosomal membrane proteins of Dictyostelium discoideum. A complex population of acidic integral membrane glycoproteins, Rab GTP-binding proteins and vacuolar ATPase subunits.", "abstract_clean": "Highly purified lysosomes, p...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0281337" ], "detected_gene_expandable": "yes", "query_expansion_benchmark": "yes" }
1053
rab11B null mutants showed no defects in growth, endocytosis or development, suggesting that the function of rab11B may be redundant with other rab genes in Dictyostelium.
[ { "gene_id": "DDB_G0287211", "gene_name": "rab11B", "synonyms": "", "gene_products": "Rab GTPase 11B" } ]
[ "http://www.ncbi.nlm.nih.gov/pubmed/9632105" ]
[ { "publication_id": 3964, "pmid": "9632105", "title": "Cloning and characterization of a Dictyostelium gene encoding a small GTPase of the Rab11 family.", "abstract_clean": "Eukaryotic cells achieve complexity by compartmentalizing a subset of cellular functions into membrane-bound organelles. Maint...
{ "has_detectable_gene": "yes", "n_detected_genes": 1, "detected_gene_ids": [ "DDB_G0287211" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
1054
Rab11C localizes to the contractile vacuole suggesting that it is a regulator of the contractile vacuole, however, overexpression of Rab11C only partially suppresses the large vacuole phenotype in disgorgin null cells unpublished data.
[ { "gene_id": "DDB_G0277101", "gene_name": "rab11C", "synonyms": "", "gene_products": "Rab GTPase 11C" }, { "gene_id": "DDB_G0280955", "gene_name": "dsgg", "synonyms": "rabGAP, disgorgin, GTPase activating protein (GAP) Dsgg", "gene_products": "Rab GTPase-activating protein Dsgg" ...
[ "http://www.ncbi.nlm.nih.gov/pubmed/18636095" ]
[ { "publication_id": 466, "pmid": "18636095", "title": "Regulation of contractile vacuole formation and activity in Dictyostelium.", "abstract_clean": "The contractile vacuole (CV) system is the osmoregulatory organelle required for survival for many free-living cells under hypotonic conditions. We i...
{ "has_detectable_gene": "yes", "n_detected_genes": 2, "detected_gene_ids": [ "DDB_G0277101", "DDB_G0280955" ], "detected_gene_expandable": "no", "query_expansion_benchmark": "no" }
End of preview. Expand in Data Studio

DictyCite

The archival and citable release is available on Zenodo: 10.5281/zenodo.20308282. The data files hosted here are identical to those in the corresponding Zenodo release.

For citation, please cite the paper together with the Zenodo DOI. Future dataset releases will continue to be archived on Zenodo and mirrored here for convenient access.

DictyCite is a benchmark for domain-specific biological literature retrieval, built from dictyBase curator notes. Each query is a compact, curator-written claim from a Dictyostelium discoideum gene summary page, and the relevance judgments are the PubMed articles the curator cited for it.

At a glance: 1,656 curator-claim queries spanning 862 unique Dictyostelium genes, linked to 1,289 unique PubMed articles (2,028 claim–article pairs), evaluated against a 20,447-article Europe PMC abstract corpus.

Loading

from datasets import load_dataset

# Main benchmark: curator claims with their cited articles (the default config, `goldset`)
queries = load_dataset("fulaibaowang/dictycite", split="train")

# Retrieval corpus
corpus = load_dataset("fulaibaowang/dictycite", "abstract_corpus", split="train")

Each config is a single JSONL file, exposed under the default split name train. The name carries no meaning: DictyCite is an evaluation benchmark and has no train/test partition.

Config File Rows Contents
goldset dictycite_goldset.jsonl 1,656 Curator claims, cited PubMed articles, LLM evidence-level labels
abstract_corpus dictycite_abstract_corpus.jsonl 20,447 Cleaned abstracts forming the retrieval corpus
query_expansion dictycite_query_expansion.jsonl 563 Goldset subset with gene-aware query-expansion variants

The repository also holds dictycite_fulltext_pmids.tsv (1,124 rows): the cited PMIDs that have a chunked full-text representation, with PMC licence tags. It is a plain file, not a config:

import pandas as pd
from huggingface_hub import hf_hub_download

path = hf_hub_download("fulaibaowang/dictycite", "dictycite_fulltext_pmids.tsv", repo_type="dataset")
fulltext = pd.read_csv(path, sep="\t", dtype={"pmid": str})

Queries join to the corpus on docs[].pmid = pmid:

pairs = [
    (q["query_id"], d["pmid"], d["evidence_level"])
    for q in queries
    for d in q["docs"]
]

Schemas

goldset

One row per query.

  • query_id - string. Stable query identifier.
  • query_text - string. Curator-written claim used as the retrieval query.
  • documents - list of strings. PubMed URLs of the cited articles.
  • docs - list of objects. Cited articles with metadata (below).
  • genes - list of objects. dictyBase gene records linked to the query (gene_id, gene_name, synonyms, gene_products).
  • query_gene_expansion - object. Gene-detection result (has_detectable_gene, n_detected_genes, detected_gene_ids, detected_gene_expandable, query_expansion_benchmark).

Each entry in docs:

  • pmid - string. PubMed ID (joins to abstract_corpus.pmid).
  • publication_id - int. dictyBase internal publication ID.
  • title - string. Article title.
  • year - int. Publication year.
  • abstract_clean - string. Cleaned abstract text.
  • evidence_level - string. LLM label, one of abstract_supports_detail, abstract_supports_core or abstract_insufficient (844 / 762 / 422 of the 2,028 pairs).
  • doc_match - string. yes if the cited article was matched to the abstract corpus.
  • reason - string. LLM rationale for the label (may be empty).
  • anchor_pos - list of ints. Character offsets of the citation anchors in the source curator note.
  • citation_captions - list of strings. Raw citation strings from the dictyBase page.

The evidence-level labels were assigned by Llama 3.3 under a fixed prompt, not by human annotators. They describe how much of the claim the abstract alone supports.

abstract_corpus

One row per article.

  • pmid - string. PubMed ID (primary key).
  • docno - string. Indexer document number (equal to pmid).
  • pmcid - string or null. PMC ID, when available.
  • doi - string or null. DOI, when available.
  • title - string. Article title.
  • authors - string or null. Comma-separated author list.
  • journal - string. Journal name.
  • year - string. Publication year.
  • text - string. Cleaned abstract text.
  • type - string. Always "abstract".
  • file - string. Source file path (provenance only).

query_expansion

The 563 goldset queries with query_expansion_benchmark == "yes". Fields as in goldset, except that the gene records sit under query_gene_expansion.detected_genes instead of a top-level genes field, plus two expanded-query fields:

  • query_text_expansion_synonyms - string. Original query with gene synonyms appended.
  • query_text_synonym_products - string. Original query with gene synonyms and product descriptions appended.

dictycite_fulltext_pmids.tsv

One row per cited PMID that has a chunked full-text representation in the paper's pipeline.

  • pmid - PubMed ID (joins to docs[].pmid; read it as a string).
  • pmcid - PMC ID, empty when the article is not in PMC.
  • license - PMC licence tag (CC BY, CC BY-NC, CC0, NO-CC CODE, ...) or NON-OA when the article is not in the PMC Open Access Subset.
  • n_chunks - number of full-text chunks for this PMID.

Full text

The paper also reports results on a chunked full-text corpus. The chunked text is not distributed, here or on Zenodo, because most of the underlying articles are outside the PMC Open Access Subset. dictycite_fulltext_pmids.tsv lists which cited articles were covered and under which licence; the PDF processing code is in the GitHub repository under scripts/public/pdf_processing/.

Licence

The data files are released under Creative Commons Attribution 4.0 International (CC BY 4.0), the same licence as the Zenodo record.

Upstream attribution:

  • Curator claims and gene annotations are derived from dictyBase gene summary pages. Please cite dictyBase when using the goldset.
  • Abstract text is sourced from PubMed via Europe PMC. NLM does not claim copyright on PubMed abstracts, and abstracts may be subject to publisher or author copyright. Users are responsible for complying with the applicable NLM/PubMed and publisher terms.

Citation

Please cite the paper, and the Zenodo record for the dataset itself:

Yun Wang, Gad Shaulsky, Tomaž Curk, Blaž Zupan. Benchmarking Literature Retrieval for a Model Organism: A Dictyostelium Case Study. Discovery Science (DS 2026), Springer, 2026 (to appear). arXiv:2610.03130.

Yun Wang. DictyCite: A Domain-Specific Biological Literature Retrieval Dataset for Dictyostelium discoideum. Zenodo, 2026. https://doi.org/10.5281/zenodo.20308282

Funding and acknowledgements

This work was funded by the European Union (Horizon Europe MSCA COFUND grant No. 101081355 - SMASH). We thank the dictyBase curators for the gene annotations and curator notes that make this resource possible, and the National Library of Medicine and Europe PMC for open access to PubMed metadata and abstracts.

Downloads last month
159

Paper for fulaibaowang/dictycite