lb_id stringlengths 10 10 | format stringclasses 1
value | metric stringclasses 1
value | messages listlengths 3 3 | metadata stringlengths 147 257 |
|---|---|---|---|---|
EP-04-0000 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ADAR", "modification": "A-to-I editing", "perturbation": "knockdown", "context": "human cells (senescence model); relevant to mammalian aging", "aging_effect": "promotes", "pmid": "35851616"} |
EP-04-0001 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ADAR", "modification": "A-to-I editing", "perturbation": "knockdown", "context": "Drosophila melanogaster neurons", "aging_effect": "promotes", "pmid": "41305850"} |
EP-04-0002 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ADARB1", "modification": "A-to-I editing; C-to-U editing", "perturbation": "loss-of-function", "context": "human centenarians; C. elegans", "aging_effect": "suppresses", "pmid": "20011587"} |
EP-04-0003 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ADARB2", "modification": "A-to-I editing", "perturbation": "reduction", "context": "human centenarians; C. elegans", "aging_effect": "suppresses", "pmid": "20011587"} |
EP-04-0004 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ADARB2", "modification": "A-to-I editing", "perturbation": "unclear", "context": "human serum/clinical cohort", "aging_effect": "neutral", "pmid": "22210125"} |
EP-04-0005 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ALKBH3", "modification": "m1A (N1-methyladenosine)", "perturbation": "knockdown", "context": "human non-small-cell lung cancer cells (in vitro and orthotopic xenograft)", "aging_effect": "suppresses", "pmid": "21285982"} |
EP-04-0006 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ALKBH3", "modification": "m1A (N1-methyladenosine)", "perturbation": "overexpression", "context": "aged hematopoietic stem cells (HSCs), mouse", "aging_effect": "suppresses", "pmid": "35400026"} |
EP-04-0007 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ALKBH5", "modification": "m6A (N6-methyladenosine)", "perturbation": "loss-of-function", "context": "human cells (cellular senescence model)", "aging_effect": "promotes", "pmid": "40817288"} |
EP-04-0008 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ALKBH5", "modification": "m6A (N6-methyladenosine)", "perturbation": "loss-of-function", "context": "macrophages in atherosclerotic plaques (human and Apoe-/- mouse)", "aging_effect": "promotes", "pmid": "40177773"} |
EP-04-0009 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ALKBH5", "modification": "m6A (N6-methyladenosine)", "perturbation": "overexpression", "context": "Mesenchymal stem cells (MSCs); osteoarthritis model", "aging_effect": "suppresses", "pmid": "37524872"} |
EP-04-0010 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "APOBEC1", "modification": "C-to-U editing", "perturbation": "unclear", "context": "N/A", "aging_effect": "neutral", "pmid": "37185728"} |
EP-04-0011 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "APOBEC1", "modification": "C-to-U editing", "perturbation": "knockout", "context": "microglia, central nervous system (mouse model)", "aging_effect": "promotes", "pmid": "29167375"} |
EP-04-0012 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "APOBEC1", "modification": "C-to-U editing", "perturbation": "overexpression", "context": "Drosophila (mitochondrially-targeted in whole organism)", "aging_effect": "promotes", "pmid": "31337756"} |
EP-04-0013 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "APOBEC3A", "modification": "C-to-U editing", "perturbation": "unclear", "context": "lung cancer (smokers)", "aging_effect": "neutral", "pmid": "38617360"} |
EP-04-0014 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "DDX21", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "human 293 embryonic kidney cells", "aging_effect": "neutral", "pmid": "21210717"} |
EP-04-0015 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "DDX21", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "neurons", "aging_effect": "neutral", "pmid": "37579947"} |
EP-04-0016 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "DKC1", "modification": "pseudouridylation (\u03a8)", "perturbation": "loss-of-function", "context": "Fibroblasts and plasma from dyskeratosis congenita (DC) patients with DKC1/TERT/TERC mutations", "aging_effect": "promotes", "pmid": "36651908"} |
EP-04-0017 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "DKC1", "modification": "pseudouridylation (\u03a8)", "perturbation": "unclear", "context": "placental mammals (comparative genomics across species including naked mole rat, humans, bats)", "aging_effect": "neutral", "pmid": "24237966"} |
EP-04-0018 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "DKC1", "modification": "pseudouridylation (\u03a8)", "perturbation": "loss-of-function", "context": "hematopoietic stem cells, bone marrow", "aging_effect": "promotes", "pmid": "25237198"} |
EP-04-0019 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FBL", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "human brain white matter", "aging_effect": "neutral", "pmid": "25376332"} |
EP-04-0020 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FBL", "modification": "2'-O-methylation", "perturbation": "knockout", "context": "human mesenchymal stem cells (hMSCs); cartilage/osteoarthritis model", "aging_effect": "promotes", "pmid": "30917318"} |
EP-04-0021 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FBL", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "C. elegans", "aging_effect": "neutral", "pmid": "38980840"} |
EP-04-0022 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FTO", "modification": "m6A (N6-methyladenosine)", "perturbation": "overexpression", "context": "ovarian granulosa cells; premature ovarian insufficiency model", "aging_effect": "suppresses", "pmid": "38918838"} |
EP-04-0023 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FTO", "modification": "m6A (N6-methyladenosine)", "perturbation": "unclear", "context": "fibroblast-like synoviocytes (rheumatoid arthritis)", "aging_effect": "neutral", "pmid": "38481810"} |
EP-04-0024 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FTSJ1", "modification": "2'-O-methylation", "perturbation": "knockout", "context": "Drosophila melanogaster", "aging_effect": "neutral", "pmid": "31943105"} |
EP-04-0025 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "HNRNPA2B1", "modification": "m6A (N6-methyladenosine)", "perturbation": "unclear", "context": "mouse strains (multiple tissues) and human cells", "aging_effect": "neutral", "pmid": "27363602"} |
EP-04-0026 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "LARP7", "modification": "2'-O-methylation", "perturbation": "loss-of-function", "context": "mammalian cells undergoing DNA damage-induced cellular senescence", "aging_effect": "promotes", "pmid": "34818543"} |
EP-04-0027 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "LARP7", "modification": "2'-O-methylation", "perturbation": "overexpression", "context": "aortic vascular cells, mouse model of atherosclerosis (HFD-fed ApoE-deficient mice)", "aging_effect": "suppresses", "pmid": "38818612"} |
EP-04-0028 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "LARP7", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "neurons (Alzheimer's disease model)", "aging_effect": "neutral", "pmid": "26890744"} |
EP-04-0029 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "METTL14", "modification": "m6A (N6-methyladenosine)", "perturbation": "knockout", "context": "vascular endothelium/smooth muscle in natural aging and D-galactose-induced aging mouse models", "aging_effect": "suppresses", "pmid": "40758401"} |
EP-04-0030 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "METTL14", "modification": "m6A (N6-methyladenosine)", "perturbation": "knockdown", "context": "intestine (mouse and Drosophila)", "aging_effect": "promotes", "pmid": "36578521"} |
EP-04-0031 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "METTL14", "modification": "m6A (N6-methyladenosine)", "perturbation": "loss-of-function", "context": "Drosophila intestinal stem cells (gut)", "aging_effect": "promotes", "pmid": "37872148"} |
EP-04-0032 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "METTL3", "modification": "m6A (N6-methyladenosine)", "perturbation": "knockdown", "context": "fibroblast-like synoviocytes (FLSs) in osteoarthritic synovium", "aging_effect": "promotes", "pmid": "34706873"} |
EP-04-0033 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "METTL3", "modification": "m6A (N6-methyladenosine)", "perturbation": "knockdown", "context": "Human lens epithelial cells / diabetic cataract tissue", "aging_effect": "promotes", "pmid": "39334185"} |
EP-04-0034 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "NOP58", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "hepatocellular carcinoma", "aging_effect": "neutral", "pmid": "40715889"} |
EP-04-0035 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "NPM1", "modification": "2'-O-methylation", "perturbation": "knockdown", "context": "human mesenchymal stem cells (hMSCs)", "aging_effect": "promotes", "pmid": "40312521"} |
EP-04-0036 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "NPM1", "modification": "2'-O-methylation", "perturbation": "inhibition", "context": "Acute myeloid leukemia (AML) cells with NPM1c mutation", "aging_effect": "suppresses", "pmid": "34301789"} |
EP-04-0037 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "NSUN2", "modification": "m5C (5-methylcytosine)", "perturbation": "knockdown", "context": "Dental pulp stem cells (DPSCs)", "aging_effect": "promotes", "pmid": "35356984"} |
EP-04-0038 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "NSUN2", "modification": "m5C (5-methylcytosine)", "perturbation": "knockout", "context": "HEK293T human cell line", "aging_effect": "promotes", "pmid": "40309035"} |
EP-04-0039 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "NSUN6", "modification": "m5C (5-methylcytosine)", "perturbation": "knockout", "context": "HEK293T human cell line", "aging_effect": "promotes", "pmid": "40309035"} |
EP-04-0040 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "NSUN6", "modification": "m5C (5-methylcytosine)", "perturbation": "knockout", "context": "osteosarcoma cells (U2OS)", "aging_effect": "neutral", "pmid": "40801921"} |
EP-04-0041 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "NSUN6", "modification": "m5C (5-methylcytosine)", "perturbation": "reduction", "context": "human brain (multiple regions) in Alzheimer's disease and traumatic brain injury", "aging_effect": "neutral", "pmid": "36646969"} |
EP-04-0042 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "PUS3", "modification": "pseudouridylation (\u03a8)", "perturbation": "unclear", "context": "Arabidopsis leaves", "aging_effect": "neutral", "pmid": "41097049"} |
EP-04-0043 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "TCOF1", "modification": "2'-O-methylation", "perturbation": "overexpression", "context": "skeletal bone / mesenchymal stem cells in aging mice", "aging_effect": "suppresses", "pmid": "39237990"} |
EP-04-0044 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "TCOF1", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "human tumors (pan-cancer analysis)", "aging_effect": "neutral", "pmid": "35093935"} |
EP-04-0045 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "Trmt6", "modification": "m1A (N1-methyladenosine)", "perturbation": "overexpression", "context": "Colorectal cancer cells / tumor microenvironment", "aging_effect": "promotes", "pmid": "41504222"} |
EP-04-0046 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "Trmt6", "modification": "m1A (N1-methyladenosine)", "perturbation": "overexpression", "context": "murine hematopoietic stem cells (HSCs)", "aging_effect": "promotes", "pmid": "38233630"} |
EP-04-0047 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "Trmt61A", "modification": "m1A (N1-methyladenosine)", "perturbation": "overexpression", "context": "Colorectal cancer cells / tumor microenvironment", "aging_effect": "promotes", "pmid": "41504222"} |
EP-04-0048 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "Trmt61A", "modification": "m1A (N1-methyladenosine)", "perturbation": "overexpression", "context": "murine hematopoietic stem cells (HSCs)", "aging_effect": "promotes", "pmid": "38233630"} |
EP-04-0049 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "Trmt61B", "modification": "m1A (N1-methyladenosine)", "perturbation": "unclear", "context": "aneuploid cancer cells", "aging_effect": "neutral", "pmid": "35869285"} |
EP-04-0050 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "WTAP", "modification": "m6A (N6-methyladenosine)", "perturbation": "unclear", "context": "vascular endothelial cells and vascular smooth muscle cells (aorta); vascular calcification/aging model", "aging_effect": "neutral", "pmid": "39280584"} |
EP-04-0051 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "WTAP", "modification": "m6A (N6-methyladenosine)", "perturbation": "overexpression", "context": "nucleus pulposus cells (intervertebral disc)", "aging_effect": "promotes", "pmid": "35304463"} |
EP-04-0052 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YBX1", "modification": "m5C (5-methylcytosine)", "perturbation": "loss-of-function", "context": "Bone marrow stromal cells (BMSCs), bone/skeletal aging", "aging_effect": "promotes", "pmid": "36943004"} |
EP-04-0053 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YBX1", "modification": "m5C (5-methylcytosine)", "perturbation": "knockdown", "context": "gastric cancer cells", "aging_effect": "suppresses", "pmid": "38965605"} |
EP-04-0054 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YBX1", "modification": "m5C (5-methylcytosine)", "perturbation": "unclear", "context": "mammalian cells (review)", "aging_effect": "neutral", "pmid": "39727969"} |
EP-04-0055 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YTHDC2", "modification": "m6A (N6-methyladenosine)", "perturbation": "unclear", "context": "GC-1 spermatogonial cells (mouse), arsenic-exposed", "aging_effect": "promotes", "pmid": "40865778"} |
EP-04-0056 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YTHDC2", "modification": "m6A (N6-methyladenosine)", "perturbation": "loss-of-function", "context": "lung macrophages (lung cancer tumor microenvironment, smokers)", "aging_effect": "promotes", "pmid": "41292214"} |
EP-04-0057 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YTHDF1", "modification": "m6A (N6-methyladenosine)", "perturbation": "unclear", "context": "kidney tubular epithelial cells (aged human/mouse kidney)", "aging_effect": "neutral", "pmid": "39736678"} |
EP-04-0058 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YTHDF1", "modification": "m6A (N6-methyladenosine)", "perturbation": "knockdown", "context": "alveolar epithelial cells and mouse lung (pulmonary fibrosis model)", "aging_effect": "promotes", "pmid": "38364577"} |
EP-04-0059 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YTHDF1", "modification": "m6A (N6-methyladenosine)", "perturbation": "knockout", "context": "mouse (murine aging model)", "aging_effect": "promotes", "pmid": "40441158"} |
EP-04-0060 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YTHDF2", "modification": "m6A (N6-methyladenosine)", "perturbation": "unclear", "context": "Nucleus pulposus cells (intervertebral disc)", "aging_effect": "promotes", "pmid": "35304463"} |
EP-04-0061 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YTHDF2", "modification": "m6A (N6-methyladenosine)", "perturbation": "unclear", "context": "human population (longevity cohort)", "aging_effect": "neutral", "pmid": "16799135"} |
EP-04-0062 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YTHDF3", "modification": "m6A (N6-methyladenosine)", "perturbation": "unclear", "context": "mouse and human oocytes (maternal aging)", "aging_effect": "neutral", "pmid": "37401155"} |
EP-04-0063 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "YTHDF3", "modification": "m6A (N6-methyladenosine)", "perturbation": "overexpression", "context": "chondrocytes / cartilage tissue (osteoarthritis)", "aging_effect": "promotes", "pmid": "41365291"} |
EP-04-0000 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ADAR", "modification": "A-to-I editing", "perturbation": "knockdown", "context": "human cells (senescence model); relevant to mammalian aging", "aging_effect": "promotes", "pmid": "35851616"} |
EP-04-0001 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ADAR", "modification": "A-to-I editing", "perturbation": "knockdown", "context": "Drosophila melanogaster neurons", "aging_effect": "promotes", "pmid": "41305850"} |
EP-04-0002 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ADARB1", "modification": "A-to-I editing; C-to-U editing", "perturbation": "loss-of-function", "context": "human centenarians; C. elegans", "aging_effect": "suppresses", "pmid": "20011587"} |
EP-04-0003 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ADARB2", "modification": "A-to-I editing", "perturbation": "reduction", "context": "human centenarians; C. elegans", "aging_effect": "suppresses", "pmid": "20011587"} |
EP-04-0004 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ADARB2", "modification": "A-to-I editing", "perturbation": "unclear", "context": "human serum/clinical cohort", "aging_effect": "neutral", "pmid": "22210125"} |
EP-04-0005 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ALKBH3", "modification": "m1A (N1-methyladenosine)", "perturbation": "knockdown", "context": "human non-small-cell lung cancer cells (in vitro and orthotopic xenograft)", "aging_effect": "suppresses", "pmid": "21285982"} |
EP-04-0006 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ALKBH3", "modification": "m1A (N1-methyladenosine)", "perturbation": "overexpression", "context": "aged hematopoietic stem cells (HSCs), mouse", "aging_effect": "suppresses", "pmid": "35400026"} |
EP-04-0007 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ALKBH5", "modification": "m6A (N6-methyladenosine)", "perturbation": "loss-of-function", "context": "human cells (cellular senescence model)", "aging_effect": "promotes", "pmid": "40817288"} |
EP-04-0008 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ALKBH5", "modification": "m6A (N6-methyladenosine)", "perturbation": "loss-of-function", "context": "macrophages in atherosclerotic plaques (human and Apoe-/- mouse)", "aging_effect": "promotes", "pmid": "40177773"} |
EP-04-0009 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "ALKBH5", "modification": "m6A (N6-methyladenosine)", "perturbation": "overexpression", "context": "Mesenchymal stem cells (MSCs); osteoarthritis model", "aging_effect": "suppresses", "pmid": "37524872"} |
EP-04-0010 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "APOBEC1", "modification": "C-to-U editing", "perturbation": "unclear", "context": "N/A", "aging_effect": "neutral", "pmid": "37185728"} |
EP-04-0011 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "APOBEC1", "modification": "C-to-U editing", "perturbation": "knockout", "context": "microglia, central nervous system (mouse model)", "aging_effect": "promotes", "pmid": "29167375"} |
EP-04-0012 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "APOBEC1", "modification": "C-to-U editing", "perturbation": "overexpression", "context": "Drosophila (mitochondrially-targeted in whole organism)", "aging_effect": "promotes", "pmid": "31337756"} |
EP-04-0013 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "APOBEC3A", "modification": "C-to-U editing", "perturbation": "unclear", "context": "lung cancer (smokers)", "aging_effect": "neutral", "pmid": "38617360"} |
EP-04-0014 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "DDX21", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "human 293 embryonic kidney cells", "aging_effect": "neutral", "pmid": "21210717"} |
EP-04-0015 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "DDX21", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "neurons", "aging_effect": "neutral", "pmid": "37579947"} |
EP-04-0016 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "DKC1", "modification": "pseudouridylation (\u03a8)", "perturbation": "loss-of-function", "context": "Fibroblasts and plasma from dyskeratosis congenita (DC) patients with DKC1/TERT/TERC mutations", "aging_effect": "promotes", "pmid": "36651908"} |
EP-04-0017 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "DKC1", "modification": "pseudouridylation (\u03a8)", "perturbation": "unclear", "context": "placental mammals (comparative genomics across species including naked mole rat, humans, bats)", "aging_effect": "neutral", "pmid": "24237966"} |
EP-04-0018 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "DKC1", "modification": "pseudouridylation (\u03a8)", "perturbation": "loss-of-function", "context": "hematopoietic stem cells, bone marrow", "aging_effect": "promotes", "pmid": "25237198"} |
EP-04-0019 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FBL", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "human brain white matter", "aging_effect": "neutral", "pmid": "25376332"} |
EP-04-0020 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FBL", "modification": "2'-O-methylation", "perturbation": "knockout", "context": "human mesenchymal stem cells (hMSCs); cartilage/osteoarthritis model", "aging_effect": "promotes", "pmid": "30917318"} |
EP-04-0021 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FBL", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "C. elegans", "aging_effect": "neutral", "pmid": "38980840"} |
EP-04-0022 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FTO", "modification": "m6A (N6-methyladenosine)", "perturbation": "overexpression", "context": "ovarian granulosa cells; premature ovarian insufficiency model", "aging_effect": "suppresses", "pmid": "38918838"} |
EP-04-0023 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FTO", "modification": "m6A (N6-methyladenosine)", "perturbation": "unclear", "context": "fibroblast-like synoviocytes (rheumatoid arthritis)", "aging_effect": "neutral", "pmid": "38481810"} |
EP-04-0024 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "FTSJ1", "modification": "2'-O-methylation", "perturbation": "knockout", "context": "Drosophila melanogaster", "aging_effect": "neutral", "pmid": "31943105"} |
EP-04-0025 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "HNRNPA2B1", "modification": "m6A (N6-methyladenosine)", "perturbation": "unclear", "context": "mouse strains (multiple tissues) and human cells", "aging_effect": "neutral", "pmid": "27363602"} |
EP-04-0026 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "LARP7", "modification": "2'-O-methylation", "perturbation": "loss-of-function", "context": "mammalian cells undergoing DNA damage-induced cellular senescence", "aging_effect": "promotes", "pmid": "34818543"} |
EP-04-0027 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "LARP7", "modification": "2'-O-methylation", "perturbation": "overexpression", "context": "aortic vascular cells, mouse model of atherosclerosis (HFD-fed ApoE-deficient mice)", "aging_effect": "suppresses", "pmid": "38818612"} |
EP-04-0028 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "LARP7", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "neurons (Alzheimer's disease model)", "aging_effect": "neutral", "pmid": "26890744"} |
EP-04-0029 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "METTL14", "modification": "m6A (N6-methyladenosine)", "perturbation": "knockout", "context": "vascular endothelium/smooth muscle in natural aging and D-galactose-induced aging mouse models", "aging_effect": "suppresses", "pmid": "40758401"} |
EP-04-0030 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "METTL14", "modification": "m6A (N6-methyladenosine)", "perturbation": "knockdown", "context": "intestine (mouse and Drosophila)", "aging_effect": "promotes", "pmid": "36578521"} |
EP-04-0031 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "METTL14", "modification": "m6A (N6-methyladenosine)", "perturbation": "loss-of-function", "context": "Drosophila intestinal stem cells (gut)", "aging_effect": "promotes", "pmid": "37872148"} |
EP-04-0032 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "METTL3", "modification": "m6A (N6-methyladenosine)", "perturbation": "knockdown", "context": "fibroblast-like synoviocytes (FLSs) in osteoarthritic synovium", "aging_effect": "promotes", "pmid": "34706873"} |
EP-04-0033 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "METTL3", "modification": "m6A (N6-methyladenosine)", "perturbation": "knockdown", "context": "Human lens epithelial cells / diabetic cataract tissue", "aging_effect": "promotes", "pmid": "39334185"} |
EP-04-0034 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "NOP58", "modification": "2'-O-methylation", "perturbation": "unclear", "context": "hepatocellular carcinoma", "aging_effect": "neutral", "pmid": "40715889"} |
EP-04-0035 | ternary | balanced_accuracy | [
{
"role": "system",
"content": "You are an expert in epitranscriptomics and aging biology. You understand how RNA modification enzymes (writers, erasers, readers) regulate gene expression and affect cellular aging. Reason from enzyme function to aging phenotype. Answer with only A, B, or C."
},
{
"r... | {"enzyme": "NPM1", "modification": "2'-O-methylation", "perturbation": "knockdown", "context": "human mesenchymal stem cells (hMSCs)", "aging_effect": "promotes", "pmid": "40312521"} |
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