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5bc844fc-e852-4270-bfaf-36ea9eface3d
Comparison
Intervention
NCT01928186
NCT00684983
All the primary trial participants do not receive any oral capecitabine, oral lapatinib ditosylate or cixutumumab IV, in conrast all the secondary trial subjects receive these.
Contradiction
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 0/28 (0.00%)" ], "Eligibility": [ "Inclusion Criteria:", " A new diagnosis of invasive breast cancer > 1.0 cm in size, ER+ clinical stage I-III", " Patient must have surgical resection followed by systemic adjuvant therapy with an aromatas...
[ "INTERVENTION 1: ", " Diagnostic (FLT PET)", " Patients with early stage, ER positive primary breast cancer undergo FLT PET scan at baseline and 1-6 weeks after the start of standard endocrine treatment. The surgery follows 1-7 days after the second FLT PET scan.", " Tracer used in the FLT PET (positron em...
{ "Adverse Events": [ "Adverse Events 1:", " Total: 4/19 (21.05%)", " Hemoglobin decreased 0/19 (0.00%)", " Hemolysis 0/19 (0.00%)", " Diarrhea 2/19 (10.53%)", " Ear, nose and throat examination abnormal 0/19 (0.00%)", " Esophageal ulcer 0/19 (0.00%)", " Gastritis 1/19 (5.26%)",...
[ "INTERVENTION 1: ", " Arm A", " Patients receive oral capecitabine twice daily on days 1-14 and oral lapatinib ditosylate once daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. lapatinib ditosylate: Given PO and capecitabine: Given PO", "INTERVE...
5bc844fc-e852-4270-bfaf-36ea9eface3d
{ "candidate": null, "checks": null, "effect": "original", "fields": null, "intent": null, "mode": "original", "strategies": null, "summary": null, "task_label_status": null, "variant": 0 }
5bc844fc-e852-4270-bfaf-36ea9eface3d__aug_substitute-syntactic_2
Comparison
Intervention
NCT01928186
NCT00684983
While all the secondary trial subjects' receive cixutumumab IV, oral lapatinib ditosylate, and oral capecitabine, none of the primary trial participants receive them.
Contradiction
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 0/28 (0.00%)" ], "Eligibility": [ "Inclusion Criteria:", " A new diagnosis of invasive breast cancer > 1.0 cm in size, ER+ clinical stage I-III", " Patient must have surgical resection followed by systemic adjuvant therapy with an aromatas...
[ "INTERVENTION 1: ", " Diagnostic (FLT PET)", " Patients with early stage, ER positive primary breast cancer undergo FLT PET scan at baseline and 1-6 weeks after the start of standard endocrine treatment. The surgery follows 1-7 days after the second FLT PET scan.", " Tracer used in the FLT PET (positron em...
{ "Adverse Events": [ "Adverse Events 1:", " Total: 4/19 (21.05%)", " Hemoglobin decreased 0/19 (0.00%)", " Hemolysis 0/19 (0.00%)", " Diarrhea 2/19 (10.53%)", " Ear, nose and throat examination abnormal 0/19 (0.00%)", " Esophageal ulcer 0/19 (0.00%)", " Gastritis 1/19 (5.26%)",...
[ "INTERVENTION 1: ", " Arm A", " Patients receive oral capecitabine twice daily on days 1-14 and oral lapatinib ditosylate once daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. lapatinib ditosylate: Given PO and capecitabine: Given PO", "INTERVE...
5bc844fc-e852-4270-bfaf-36ea9eface3d
{ "candidate": "5bc844fc-e852-4270-bfaf-36ea9eface3d__substitute-syntactic_2", "checks": { "canonical": null, "fidelity": "pass", "guards": "pass", "negation": null, "relabel": null, "retention": "pass", "structural": "pass" }, "effect": "preserving", "fields": [ "Statement" ...
5bc844fc-e852-4270-bfaf-36ea9eface3d__aug_recast_2
Comparison
Intervention
NCT01928186
NCT00684983
While no primary trial participants receive oral capecitabine, oral lapatinib ditosylate, or cixutumumab IV, all secondary trial subjects receive these.
Contradiction
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 0/28 (0.00%)" ], "Eligibility": [ "Inclusion Criteria:", " A new diagnosis of invasive breast cancer > 1.0 cm in size, ER+ clinical stage I-III", " Patient must have surgical resection followed by systemic adjuvant therapy with an aromatas...
[ "INTERVENTION 1: ", " Diagnostic (FLT PET)", " Patients with early stage, ER positive primary breast cancer undergo FLT PET scan at baseline and 1-6 weeks after the start of standard endocrine treatment. The surgery follows 1-7 days after the second FLT PET scan.", " Tracer used in the FLT PET (positron em...
{ "Adverse Events": [ "Adverse Events 1:", " Total: 4/19 (21.05%)", " Hemoglobin decreased 0/19 (0.00%)", " Hemolysis 0/19 (0.00%)", " Diarrhea 2/19 (10.53%)", " Ear, nose and throat examination abnormal 0/19 (0.00%)", " Esophageal ulcer 0/19 (0.00%)", " Gastritis 1/19 (5.26%)",...
[ "INTERVENTION 1: ", " Arm A", " Patients receive oral capecitabine twice daily on days 1-14 and oral lapatinib ditosylate once daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. lapatinib ditosylate: Given PO and capecitabine: Given PO", "INTERVE...
5bc844fc-e852-4270-bfaf-36ea9eface3d
{ "candidate": "5bc844fc-e852-4270-bfaf-36ea9eface3d__recast_2", "checks": { "canonical": null, "fidelity": "pass", "guards": "pass", "negation": null, "relabel": null, "retention": "pass", "structural": "pass" }, "effect": "preserving", "fields": [ "Statement" ], "intent":...
5bc844fc-e852-4270-bfaf-36ea9eface3d__aug_substitute-syntactic_3
Comparison
Intervention
NCT01928186
NCT00684983
While all the secondary trial subjects' do, none of the primary trial participants receive cixutumumab IV, oral lapatinib ditosylate, or oral capecitabine.
Contradiction
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 0/28 (0.00%)" ], "Eligibility": [ "Inclusion Criteria:", " A new diagnosis of invasive breast cancer > 1.0 cm in size, ER+ clinical stage I-III", " Patient must have surgical resection followed by systemic adjuvant therapy with an aromatas...
[ "INTERVENTION 1: ", " Diagnostic (FLT PET)", " Patients with early stage, ER positive primary breast cancer undergo FLT PET scan at baseline and 1-6 weeks after the start of standard endocrine treatment. The surgery follows 1-7 days after the second FLT PET scan.", " Tracer used in the FLT PET (positron em...
{ "Adverse Events": [ "Adverse Events 1:", " Total: 4/19 (21.05%)", " Hemoglobin decreased 0/19 (0.00%)", " Hemolysis 0/19 (0.00%)", " Diarrhea 2/19 (10.53%)", " Ear, nose and throat examination abnormal 0/19 (0.00%)", " Esophageal ulcer 0/19 (0.00%)", " Gastritis 1/19 (5.26%)",...
[ "INTERVENTION 1: ", " Arm A", " Patients receive oral capecitabine twice daily on days 1-14 and oral lapatinib ditosylate once daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. lapatinib ditosylate: Given PO and capecitabine: Given PO", "INTERVE...
5bc844fc-e852-4270-bfaf-36ea9eface3d
{ "candidate": "5bc844fc-e852-4270-bfaf-36ea9eface3d__substitute-syntactic_3", "checks": { "canonical": null, "fidelity": "pass", "guards": "pass", "negation": null, "relabel": null, "retention": "pass", "structural": "pass" }, "effect": "preserving", "fields": [ "Statement" ...
5bc844fc-e852-4270-bfaf-36ea9eface3d__aug_substitute-syntactic_1
Comparison
Intervention
NCT01928186
NCT00684983
While all secondary trial subjects receive oral capecitabine, oral lapatinib ditosylate, and cixutumumab IV, none of the primary trial participants receive them.
Contradiction
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 0/28 (0.00%)" ], "Eligibility": [ "Inclusion Criteria:", " A new diagnosis of invasive breast cancer > 1.0 cm in size, ER+ clinical stage I-III", " Patient must have surgical resection followed by systemic adjuvant therapy with an aromatas...
[ "INTERVENTION 1: ", " Diagnostic (FLT PET)", " Patients with early stage, ER positive primary breast cancer undergo FLT PET scan at baseline and 1-6 weeks after the start of standard endocrine treatment. The surgery follows 1-7 days after the second FLT PET scan.", " Tracer used in the FLT PET (positron em...
{ "Adverse Events": [ "Adverse Events 1:", " Total: 4/19 (21.05%)", " Hemoglobin decreased 0/19 (0.00%)", " Hemolysis 0/19 (0.00%)", " Diarrhea 2/19 (10.53%)", " Ear, nose and throat examination abnormal 0/19 (0.00%)", " Esophageal ulcer 0/19 (0.00%)", " Gastritis 1/19 (5.26%)",...
[ "INTERVENTION 1: ", " Arm A", " Patients receive oral capecitabine twice daily on days 1-14 and oral lapatinib ditosylate once daily on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. lapatinib ditosylate: Given PO and capecitabine: Given PO", "INTERVE...
5bc844fc-e852-4270-bfaf-36ea9eface3d
{ "candidate": "5bc844fc-e852-4270-bfaf-36ea9eface3d__substitute-syntactic_1", "checks": { "canonical": null, "fidelity": "pass", "guards": "pass", "negation": null, "relabel": null, "retention": "pass", "structural": "pass" }, "effect": "preserving", "fields": [ "Statement" ...
dbed5471-c2fc-45b5-b26f-430c9fa37a37
Comparison
Adverse Events
NCT00093145
NCT00703326
Heart-related adverse events were recorded in both the primary trial and the secondary trial.
Entailment
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 5/32 (15.63%)", " Febrile neutropenia 1/32 (3.13%)", " Supraventricular tachycardia 1/32 (3.13%)", " Hypersensitivity 2/32 (6.25%)", " Catheter site infection 1/32 (3.13%)", " Confusional state 1/32 (3.13%)" ], "Eligibility": [ ...
[ "Adverse Events 1:", " Total: 5/32 (15.63%)", " Febrile neutropenia 1/32 (3.13%)", " Supraventricular tachycardia 1/32 (3.13%)", " Hypersensitivity 2/32 (6.25%)", " Catheter site infection 1/32 (3.13%)", " Confusional state 1/32 (3.13%)" ]
{ "Adverse Events": [ "Adverse Events 1:", " Total: 285/752 (37.90%)", " Anaemia 2/752 (0.27%)", " Disseminated intravascular coagulation 2/752 (0.27%)", " Febrile neutropenia 51/752 (6.78%)", " Neutropenia 47/752 (6.25%)", " Thrombocytopenia 2/752 (0.27%)", " Atrial fibrillatio...
[ "Adverse Events 1:", " Total: 285/752 (37.90%)", " Anaemia 2/752 (0.27%)", " Disseminated intravascular coagulation 2/752 (0.27%)", " Febrile neutropenia 51/752 (6.78%)", " Neutropenia 47/752 (6.25%)", " Thrombocytopenia 2/752 (0.27%)", " Atrial fibrillation 1/752 (0.13%)", " Atrial flutter ...
dbed5471-c2fc-45b5-b26f-430c9fa37a37
{ "candidate": null, "checks": null, "effect": "original", "fields": null, "intent": null, "mode": "original", "strategies": null, "summary": null, "task_label_status": null, "variant": 0 }
dbed5471-c2fc-45b5-b26f-430c9fa37a37__aug_recast_3
Comparison
Adverse Events
NCT00093145
NCT00703326
The primary trial recorded Heart-related adverse events. The secondary trial also recorded them.
Entailment
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 5/32 (15.63%)", " Febrile neutropenia 1/32 (3.13%)", " Supraventricular tachycardia 1/32 (3.13%)", " Hypersensitivity 2/32 (6.25%)", " Catheter site infection 1/32 (3.13%)", " Confusional state 1/32 (3.13%)" ], "Eligibility": [ ...
[ "Adverse Events 1:", " Total: 5/32 (15.63%)", " Febrile neutropenia 1/32 (3.13%)", " Supraventricular tachycardia 1/32 (3.13%)", " Hypersensitivity 2/32 (6.25%)", " Catheter site infection 1/32 (3.13%)", " Confusional state 1/32 (3.13%)" ]
{ "Adverse Events": [ "Adverse Events 1:", " Total: 285/752 (37.90%)", " Anaemia 2/752 (0.27%)", " Disseminated intravascular coagulation 2/752 (0.27%)", " Febrile neutropenia 51/752 (6.78%)", " Neutropenia 47/752 (6.25%)", " Thrombocytopenia 2/752 (0.27%)", " Atrial fibrillatio...
[ "Adverse Events 1:", " Total: 285/752 (37.90%)", " Anaemia 2/752 (0.27%)", " Disseminated intravascular coagulation 2/752 (0.27%)", " Febrile neutropenia 51/752 (6.78%)", " Neutropenia 47/752 (6.25%)", " Thrombocytopenia 2/752 (0.27%)", " Atrial fibrillation 1/752 (0.13%)", " Atrial flutter ...
dbed5471-c2fc-45b5-b26f-430c9fa37a37
{ "candidate": "dbed5471-c2fc-45b5-b26f-430c9fa37a37__recast_3", "checks": { "canonical": null, "fidelity": "pass", "guards": "pass", "negation": null, "relabel": null, "retention": "pass", "structural": "pass" }, "effect": "preserving", "fields": [ "Statement" ], "intent":...
dbed5471-c2fc-45b5-b26f-430c9fa37a37__aug_negate_true-recast_1
Comparison
Adverse Events
NCT00093145
NCT00703326
At least one of the primary trial or the secondary trial did not record Heart-related adverse events.
Contradiction
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 5/32 (15.63%)", " Febrile neutropenia 1/32 (3.13%)", " Supraventricular tachycardia 1/32 (3.13%)", " Hypersensitivity 2/32 (6.25%)", " Catheter site infection 1/32 (3.13%)", " Confusional state 1/32 (3.13%)" ], "Eligibility": [ ...
[ "Adverse Events 1:", " Total: 5/32 (15.63%)", " Febrile neutropenia 1/32 (3.13%)", " Supraventricular tachycardia 1/32 (3.13%)", " Hypersensitivity 2/32 (6.25%)", " Catheter site infection 1/32 (3.13%)", " Confusional state 1/32 (3.13%)" ]
{ "Adverse Events": [ "Adverse Events 1:", " Total: 285/752 (37.90%)", " Anaemia 2/752 (0.27%)", " Disseminated intravascular coagulation 2/752 (0.27%)", " Febrile neutropenia 51/752 (6.78%)", " Neutropenia 47/752 (6.25%)", " Thrombocytopenia 2/752 (0.27%)", " Atrial fibrillatio...
[ "Adverse Events 1:", " Total: 285/752 (37.90%)", " Anaemia 2/752 (0.27%)", " Disseminated intravascular coagulation 2/752 (0.27%)", " Febrile neutropenia 51/752 (6.78%)", " Neutropenia 47/752 (6.25%)", " Thrombocytopenia 2/752 (0.27%)", " Atrial fibrillation 1/752 (0.13%)", " Atrial flutter ...
dbed5471-c2fc-45b5-b26f-430c9fa37a37
{ "candidate": "dbed5471-c2fc-45b5-b26f-430c9fa37a37__negate_true-recast_1", "checks": { "canonical": "not_applicable", "fidelity": "pass", "guards": "pass", "negation": "pass", "relabel": "not_applicable", "retention": "pass", "structural": "pass" }, "effect": "label_negated", "fi...
dbed5471-c2fc-45b5-b26f-430c9fa37a37__aug_recast_1
Comparison
Adverse Events
NCT00093145
NCT00703326
Both the primary trial and the secondary trial included records of Heart-related adverse events.
Entailment
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 5/32 (15.63%)", " Febrile neutropenia 1/32 (3.13%)", " Supraventricular tachycardia 1/32 (3.13%)", " Hypersensitivity 2/32 (6.25%)", " Catheter site infection 1/32 (3.13%)", " Confusional state 1/32 (3.13%)" ], "Eligibility": [ ...
[ "Adverse Events 1:", " Total: 5/32 (15.63%)", " Febrile neutropenia 1/32 (3.13%)", " Supraventricular tachycardia 1/32 (3.13%)", " Hypersensitivity 2/32 (6.25%)", " Catheter site infection 1/32 (3.13%)", " Confusional state 1/32 (3.13%)" ]
{ "Adverse Events": [ "Adverse Events 1:", " Total: 285/752 (37.90%)", " Anaemia 2/752 (0.27%)", " Disseminated intravascular coagulation 2/752 (0.27%)", " Febrile neutropenia 51/752 (6.78%)", " Neutropenia 47/752 (6.25%)", " Thrombocytopenia 2/752 (0.27%)", " Atrial fibrillatio...
[ "Adverse Events 1:", " Total: 285/752 (37.90%)", " Anaemia 2/752 (0.27%)", " Disseminated intravascular coagulation 2/752 (0.27%)", " Febrile neutropenia 51/752 (6.78%)", " Neutropenia 47/752 (6.25%)", " Thrombocytopenia 2/752 (0.27%)", " Atrial fibrillation 1/752 (0.13%)", " Atrial flutter ...
dbed5471-c2fc-45b5-b26f-430c9fa37a37
{ "candidate": "dbed5471-c2fc-45b5-b26f-430c9fa37a37__recast_1", "checks": { "canonical": null, "fidelity": "pass", "guards": "pass", "negation": null, "relabel": null, "retention": "pass", "structural": "pass" }, "effect": "preserving", "fields": [ "Statement" ], "intent":...
dbed5471-c2fc-45b5-b26f-430c9fa37a37__aug_substitute-syntactic_1
Comparison
Adverse Events
NCT00093145
NCT00703326
Both the primary trial and the secondary trial had documented Heart-related adverse events.
Entailment
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 5/32 (15.63%)", " Febrile neutropenia 1/32 (3.13%)", " Supraventricular tachycardia 1/32 (3.13%)", " Hypersensitivity 2/32 (6.25%)", " Catheter site infection 1/32 (3.13%)", " Confusional state 1/32 (3.13%)" ], "Eligibility": [ ...
[ "Adverse Events 1:", " Total: 5/32 (15.63%)", " Febrile neutropenia 1/32 (3.13%)", " Supraventricular tachycardia 1/32 (3.13%)", " Hypersensitivity 2/32 (6.25%)", " Catheter site infection 1/32 (3.13%)", " Confusional state 1/32 (3.13%)" ]
{ "Adverse Events": [ "Adverse Events 1:", " Total: 285/752 (37.90%)", " Anaemia 2/752 (0.27%)", " Disseminated intravascular coagulation 2/752 (0.27%)", " Febrile neutropenia 51/752 (6.78%)", " Neutropenia 47/752 (6.25%)", " Thrombocytopenia 2/752 (0.27%)", " Atrial fibrillatio...
[ "Adverse Events 1:", " Total: 285/752 (37.90%)", " Anaemia 2/752 (0.27%)", " Disseminated intravascular coagulation 2/752 (0.27%)", " Febrile neutropenia 51/752 (6.78%)", " Neutropenia 47/752 (6.25%)", " Thrombocytopenia 2/752 (0.27%)", " Atrial fibrillation 1/752 (0.13%)", " Atrial flutter ...
dbed5471-c2fc-45b5-b26f-430c9fa37a37
{ "candidate": "dbed5471-c2fc-45b5-b26f-430c9fa37a37__substitute-syntactic_1", "checks": { "canonical": null, "fidelity": "pass", "guards": "pass", "negation": null, "relabel": null, "retention": "pass", "structural": "pass" }, "effect": "preserving", "fields": [ "Statement" ...
20c35c89-8d23-4be3-b603-ac0ee0f3b4de
Single
Eligibility
NCT01097642
null
Adult Patients with histologic confirmation of invasive bilateral breast carcinoma (T1 N1 M1) are eligible for the primary trial.
Contradiction
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 2/15 (13.33%)", " Neutropenia 0/15 (0.00%)", " GI Events 0/15 (0.00%)", " Peripheral neuropathy 2/15 (13.33%)", " Rash 0/15 (0.00%)", "Adverse Events 2:", " Total: 6/25 (24.00%)", " Neutropenia 2/25 (8.00%)", " GI...
[ "Inclusion Criteria:", " Patients with histologic confirmation of invasive breast carcinoma.", " Patients must have intact primary tumor.", " Patients greater than or equal to 18 years.", " Patients should have T1N1-3M0 or T2-4 N0-3M0.", " Patients with bilateral breast cancer are eligible.", " Pa...
null
null
20c35c89-8d23-4be3-b603-ac0ee0f3b4de
{ "candidate": null, "checks": null, "effect": "original", "fields": null, "intent": null, "mode": "original", "strategies": null, "summary": null, "task_label_status": null, "variant": 0 }
20c35c89-8d23-4be3-b603-ac0ee0f3b4de__aug_biomedical-recast_1
Single
Eligibility
NCT01097642
null
The primary trial eligible patients are Adults with histologic confirmation of invasive Dukes A rectal cancer (T1 N1 M1).
Contradiction
Base_Statement
null
null
{ "Adverse Events": [ "Adverse Events 1:", " Total: 2/15 (13.33%)", " Neutropenia 0/15 (0.00%)", " GI Events 0/15 (0.00%)", " Peripheral neuropathy 2/15 (13.33%)", " Rash 0/15 (0.00%)", "Adverse Events 2:", " Total: 6/25 (24.00%)", " Neutropenia 2/25 (8.00%)", " GI...
[ "Inclusion Criteria:", " Patients with histologic confirmation of invasive breast carcinoma.", " Patients must have intact primary tumor.", " Patients greater than or equal to 18 years.", " Patients should have T1N1-3M0 or T2-4 N0-3M0.", " Patients with bilateral breast cancer are eligible.", " Pa...
null
null
20c35c89-8d23-4be3-b603-ac0ee0f3b4de
{ "candidate": "20c35c89-8d23-4be3-b603-ac0ee0f3b4de__biomedical-recast_1", "checks": { "canonical": "pass", "fidelity": "pass", "guards": "pass", "negation": null, "relabel": "pass", "retention": "pass", "structural": "pass" }, "effect": "semantic_change", "fields": [ "Stateme...
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