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train
abstract
0
31,715,818
0-dimensional biomaterials lack inductive properties.
New opportunities: the use of nanotechnologies to manipulate and track stem cells.
Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, carbon nanotubes, and polyplexes for the intracellular delivery of genes/oligonucleo...
Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic nanoparticles and quantum dots for stem cell labeling and in vivo tracking; nanoparticles, carbon nanotubes, and polyplexes for the intracellular delivery of genes/oligonucleo...
relevant
1
train
abstract
0
15,478,227
0-dimensional biomaterials lack inductive properties.
Whole-genome sequencing of Oryza brachyantha reveals mechanisms underlying Oryza genome evolution
The wild species of the genus Oryza contain a largely untapped reservoir of agronomically important genes for rice improvement. Here we report the 261-Mb de novo assembled genome sequence of Oryza brachyantha. Low activity of long-terminal repeat retrotransposons and massive internal deletions of ancient long-terminal ...
The wild species of the genus Oryza contain a largely untapped reservoir of agronomically important genes for rice improvement. Here we report the 261-Mb de novo assembled genome sequence of Oryza brachyantha. Low activity of long-terminal repeat retrotransposons and massive internal deletions of ancient long-terminal ...
not_relevant
0
train
abstract
0
10,608,397
0-dimensional biomaterials lack inductive properties.
High-performance neuroprosthetic control by an individual with tetraplegia.
BACKGROUND Paralysis or amputation of an arm results in the loss of the ability to orient the hand and grasp, manipulate, and carry objects, functions that are essential for activities of daily living. Brain-machine interfaces could provide a solution to restoring many of these lost functions. We therefore tested wheth...
BACKGROUND Paralysis or amputation of an arm results in the loss of the ability to orient the hand and grasp, manipulate, and carry objects, functions that are essential for activities of daily living. Brain-machine interfaces could provide a solution to restoring many of these lost functions. We therefore tested wheth...
not_relevant
0
train
abstract
10
32,587,939
4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.
Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its role in β-cell function remains unclear. Here we provide e...
Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an important regulator of the ER stress signalling pathway; however, its role in β-cell function remains unclear. Here we provide e...
relevant
1
train
abstract
10
11,360,768
4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.
Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence
OBJECTIVE To evaluate the effects of dietary and lifestyle interventions in pregnancy on maternal and fetal weight and to quantify the effects of these interventions on obstetric outcomes. DESIGN Systematic review and meta-analysis. DATA SOURCES Major databases from inception to January 2012 without language restrictio...
OBJECTIVE To evaluate the effects of dietary and lifestyle interventions in pregnancy on maternal and fetal weight and to quantify the effects of these interventions on obstetric outcomes. DESIGN Systematic review and meta-analysis. DATA SOURCES Major databases from inception to January 2012 without language restrictio...
not_relevant
0
train
abstract
10
1,887,056
4-PBA treatment decreases endoplasmic reticulum stress in response to general endoplasmic reticulum stress markers.
Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress.
OBJECTIVE The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress. METHOD Plasma interleukin (IL)-6, lymphocyte subsets, and DNA binding of nuclear factor (NF)-kB in peripheral blood mononuclear cells were compared i...
OBJECTIVE The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress. METHOD Plasma interleukin (IL)-6, lymphocyte subsets, and DNA binding of nuclear factor (NF)-kB in peripheral blood mononuclear cells were compared i...
not_relevant
0
train
abstract
1,000
16,472,469
Pyridostatin stabilizes the G - quadruplex in the telomeric region.
Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds
G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks. We have previously shown that HR facil...
G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks. We have previously shown that HR facil...
relevant
1
train
abstract
1,000
24,721,347
Pyridostatin stabilizes the G - quadruplex in the telomeric region.
The last and the next hundred years of malariology.
The founding fathers of malariology combined scientific originality, perseverance in research, strong characters, breadth of interest and social concern. A hundred years later research and understanding has made immense progress but the world still bears a huge burden of malaria. For the next century research requires ...
The founding fathers of malariology combined scientific originality, perseverance in research, strong characters, breadth of interest and social concern. A hundred years later research and understanding has made immense progress but the world still bears a huge burden of malaria. For the next century research requires ...
not_relevant
0
train
abstract
1,000
26,118,532
Pyridostatin stabilizes the G - quadruplex in the telomeric region.
The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures.
Demonstration of the existence of G-quadruplex structures in telomeres of Stylonychia macronuclei and in the promoter of c-myc in human cells has validated these secondary DNA structures as potential targets for drug design. The next important issue is the selectivity of G-quadruplex-interactive agents for the differen...
Demonstration of the existence of G-quadruplex structures in telomeres of Stylonychia macronuclei and in the promoter of c-myc in human cells has validated these secondary DNA structures as potential targets for drug design. The next important issue is the selectivity of G-quadruplex-interactive agents for the differen...
not_relevant
0
train
abstract
1,001
5,702,790
R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.
Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.
Drosophila Dicer-2 generates small interfering RNAs (siRNAs) from long double-stranded RNA (dsRNA), whereas Dicer-1 produces microRNAs (miRNAs) from pre-miRNA. What makes the two Dicers specific for their biological substrates? We find that purified Dicer-2 can efficiently cleave pre-miRNA, but that inorganic phosphate...
Drosophila Dicer-2 generates small interfering RNAs (siRNAs) from long double-stranded RNA (dsRNA), whereas Dicer-1 produces microRNAs (miRNAs) from pre-miRNA. What makes the two Dicers specific for their biological substrates? We find that purified Dicer-2 can efficiently cleave pre-miRNA, but that inorganic phosphate...
relevant
1
train
abstract
1,001
23,245,050
R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.
Dietary status of trained female cyclists.
Dietary status was evaluated in eight highly trained female cyclists. Each cyclist kept a 3-day weighed food record. Diets were analyzed for nutrient content using a computerized software package. Blood was also obtained and evaluated for hemoglobin, hematocrit, and albumin. For an athletic group, the cyclists' diets w...
Dietary status was evaluated in eight highly trained female cyclists. Each cyclist kept a 3-day weighed food record. Diets were analyzed for nutrient content using a computerized software package. Blood was also obtained and evaluated for hemoglobin, hematocrit, and albumin. For an athletic group, the cyclists' diets w...
not_relevant
0
train
abstract
1,001
8,006,440
R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA.
Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells
Considerable details about microRNA (miRNA) biogenesis and regulation have been uncovered, but little is known about the fate of the miRNA subsequent to target regulation. To gain insight into this process, we carried out kinetic analysis of a miRNA's turnover following termination of its biogenesis and during regulati...
Considerable details about microRNA (miRNA) biogenesis and regulation have been uncovered, but little is known about the fate of the miRNA subsequent to target regulation. To gain insight into this process, we carried out kinetic analysis of a miRNA's turnover following termination of its biogenesis and during regulati...
not_relevant
0
train
abstract
1,002
13,639,330
RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.
Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors
Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impose ligand dependency for gene activation remains unknown. Here we report an unexpected and general strategy that i...
Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impose ligand dependency for gene activation remains unknown. Here we report an unexpected and general strategy that i...
relevant
1
train
abstract
1,002
22,003,328
RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.
A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats.
Clustered regularly interspaced short palindromic repeats (CRISPRs) together with the associated CAS proteins protect microbial cells from invasion by foreign genetic elements using presently unknown molecular mechanisms. All CRISPR systems contain proteins of the CAS2 family, suggesting that these uncharacterized prot...
Clustered regularly interspaced short palindromic repeats (CRISPRs) together with the associated CAS proteins protect microbial cells from invasion by foreign genetic elements using presently unknown molecular mechanisms. All CRISPR systems contain proteins of the CAS2 family, suggesting that these uncharacterized prot...
not_relevant
0
train
abstract
1,002
11,328,820
RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters.
NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neutrophils isolated from patients with various autoimmune diseases display enhanced neutrophil extracellular trap (NET...
The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neutrophils isolated from patients with various autoimmune diseases display enhanced neutrophil extracellular trap (NET...
not_relevant
0
train
abstract
1,003
14,332,945
RAD52 is involved in break-induced DNA replication (BIR).
Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks
Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks. To better understand BIR, we performed a targeted siRNA screen for genes whose depletion inhibited G1 to S...
Human cancers are characterized by the presence of oncogene-induced DNA replication stress (DRS), making them dependent on repair pathways such as break-induced replication (BIR) for damaged DNA replication forks. To better understand BIR, we performed a targeted siRNA screen for genes whose depletion inhibited G1 to S...
relevant
1
train
abstract
1,003
4,319,844
RAD52 is involved in break-induced DNA replication (BIR).
Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes.
Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset of cancers. By analyzing telomerase-positive cells and their human TERC knockout-derived ALT human cell lines, we show that ALT cells harbor more fragile telomeres representing telomere replicat...
Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that occurs in a subset of cancers. By analyzing telomerase-positive cells and their human TERC knockout-derived ALT human cell lines, we show that ALT cells harbor more fragile telomeres representing telomere replicat...
relevant
1
train
abstract
1,003
4,899,981
RAD52 is involved in break-induced DNA replication (BIR).
Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism
Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis in response to DNA replication stress. At CFSs, this fragility is associated with a delay in the completion of DNA replication until early mitosis, whereupon cells are proposed to switch to a RAD52-de...
Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis in response to DNA replication stress. At CFSs, this fragility is associated with a delay in the completion of DNA replication until early mitosis, whereupon cells are proposed to switch to a RAD52-de...
relevant
1
train
abstract
1,003
17,088,791
RAD52 is involved in break-induced DNA replication (BIR).
Common BRCA1 variants and susceptibility to breast and ovarian cancer in the general population.
Most multiple case families of young onset breast cancer and ovarian cancer are thought to be due to highly penetrant mutations in the predisposing genes BRCA1 and BRCA2. However, these mutations are uncommon in the population and they probably account for only a few percent of all breast cancer incidence. A much large...
Most multiple case families of young onset breast cancer and ovarian cancer are thought to be due to highly penetrant mutations in the predisposing genes BRCA1 and BRCA2. However, these mutations are uncommon in the population and they probably account for only a few percent of all breast cancer incidence. A much large...
not_relevant
0
train
abstract
1,003
8,577,229
RAD52 is involved in break-induced DNA replication (BIR).
Break-induced DNA replication.
Recombination-dependent DNA replication, often called break-induced replication (BIR), was initially invoked to explain recombination events in bacteriophage but it has recently been recognized as a fundamentally important mechanism to repair double-strand chromosome breaks in eukaryotes. This mechanism appears to be c...
Recombination-dependent DNA replication, often called break-induced replication (BIR), was initially invoked to explain recombination events in bacteriophage but it has recently been recognized as a fundamentally important mechanism to repair double-strand chromosome breaks in eukaryotes. This mechanism appears to be c...
not_relevant
0
train
abstract
1,004
2,734,421
RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens. However, signals underlying mTEC development remain largely unclear. Here, we demonstrate crucial regulation of mTEC development by receptor activ...
Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens. However, signals underlying mTEC development remain largely unclear. Here, we demonstrate crucial regulation of mTEC development by receptor activ...
relevant
1
train
abstract
1,004
301,838
RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.
Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance. Here we sh...
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance. Here we sh...
relevant
1
train
abstract
1,004
3,952,288
RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.
RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of self-reactive specificities. Here we demonstrate a novel role for a CD4+3− inducer cell population, previously linked to ...
Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of self-reactive specificities. Here we demonstrate a novel role for a CD4+3− inducer cell population, previously linked to ...
relevant
1
train
abstract
1,004
14,864,285
RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.
YOKO HONDA AND SHUJI HONDA 1
Longevity is regulated by the daf-2 gene network in Caenorhabditis elegans. Mutations in the daf-2 gene, which encodes a member of the insulin receptor family, confer the life extension (Age) phenotype and the constitutive dauer (a growth-arrested larval form specialized for dispersal) formation phenotype. The Age phen...
Longevity is regulated by the daf-2 gene network in Caenorhabditis elegans. Mutations in the daf-2 gene, which encodes a member of the insulin receptor family, confer the life extension (Age) phenotype and the constitutive dauer (a growth-arrested larval form specialized for dispersal) formation phenotype. The Age phen...
not_relevant
0
train
abstract
1,004
39,128,592
RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells.
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that th...
The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that th...
not_relevant
0
train
abstract
1,005
2,734,421
RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens. However, signals underlying mTEC development remain largely unclear. Here, we demonstrate crucial regulation of mTEC development by receptor activ...
Medullary thymic epithelial cells (mTECs) establish T cell self-tolerance through the expression of autoimmune regulator (Aire) and peripheral tissue-specific self-antigens. However, signals underlying mTEC development remain largely unclear. Here, we demonstrate crucial regulation of mTEC development by receptor activ...
relevant
1
train
abstract
1,005
301,838
RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.
Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance. Here we sh...
The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance. Here we sh...
relevant
1
train
abstract
1,005
3,952,288
RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.
RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of self-reactive specificities. Here we demonstrate a novel role for a CD4+3− inducer cell population, previously linked to ...
Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of self-reactive specificities. Here we demonstrate a novel role for a CD4+3− inducer cell population, previously linked to ...
relevant
1
train
abstract
1,005
6,308,416
RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.
Role of boundary conditions in an experimental model of epithelial wound healing.
Coordinated cell movements in epithelial layers are essential for proper tissue morphogenesis and homeostasis, but our understanding of the mechanisms that coordinate the behavior of multiple cells in these processes is far from complete. Recent experiments with Madin-Darby canine kidney epithelial monolayers revealed ...
Coordinated cell movements in epithelial layers are essential for proper tissue morphogenesis and homeostasis, but our understanding of the mechanisms that coordinate the behavior of multiple cells in these processes is far from complete. Recent experiments with Madin-Darby canine kidney epithelial monolayers revealed ...
not_relevant
0
train
abstract
1,005
39,128,592
RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells.
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that th...
The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that th...
not_relevant
0
train
abstract
1,006
4,926,049
RTEL1 interacts with TRF2 through a C4C4 motif
TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding
The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is important to prevent telomere fragility, but how RTEL1 engages with the telomere to promote t-loop unwinding is unclear. Here, we establish that the ...
The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is important to prevent telomere fragility, but how RTEL1 engages with the telomere to promote t-loop unwinding is unclear. Here, we establish that the ...
relevant
1
train
abstract
1,006
14,192,687
RTEL1 interacts with TRF2 through a C4C4 motif
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.
The long-term goal of nuclear transfer or alternative reprogramming approaches is to create patient-specific donor cells for transplantation therapy, avoiding immunorejection, a major complication in current transplantation medicine. It was recently shown that the four transcription factors Oct4, Sox2, Klf4, and c-Myc ...
The long-term goal of nuclear transfer or alternative reprogramming approaches is to create patient-specific donor cells for transplantation therapy, avoiding immunorejection, a major complication in current transplantation medicine. It was recently shown that the four transcription factors Oct4, Sox2, Klf4, and c-Myc ...
not_relevant
0
train
abstract
1,006
7,848,113
RTEL1 interacts with TRF2 through a C4C4 motif
Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats.
Vertebrate telomeres consist of tandem repeats of T2AG3 and associated proteins including the telomeric DNA-binding proteins, TRF1 and TRF2. It has been proposed that telomeres assume two interswitchable states, the open state that is accessible to various trans-acting factors and the closed state that excludes those f...
Vertebrate telomeres consist of tandem repeats of T2AG3 and associated proteins including the telomeric DNA-binding proteins, TRF1 and TRF2. It has been proposed that telomeres assume two interswitchable states, the open state that is accessible to various trans-acting factors and the closed state that excludes those f...
not_relevant
0
train
abstract
1,008
2,547,636
RUNX is not expressed in skin tissue.
Human epidermal stem cell function is regulated by circadian oscillations.
Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that in human epidermal stem cells and their differentiated counterparts, core clock genes peak in a successive and phased manne...
Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that in human epidermal stem cells and their differentiated counterparts, core clock genes peak in a successive and phased manne...
relevant
1
train
abstract
1,008
8,182,950
RUNX is not expressed in skin tissue.
Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose.
In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after intradermal injection, greatly enhances adjuvant efficacy at low do...
In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after intradermal injection, greatly enhances adjuvant efficacy at low do...
not_relevant
0
train
abstract
1,008
38,037,690
RUNX is not expressed in skin tissue.
Three-dimensional chemical imaging of skin using stimulated Raman scattering microscopy
Abstract. Stimulated Raman scattering (SRS) microscopy is used to generate structural and chemical three-dimensional images of native skin. We employed SRS microscopy to investigate the microanatomical features of skin and penetration of topically applied materials. Image depth stacks are collected at distinct waveleng...
Abstract. Stimulated Raman scattering (SRS) microscopy is used to generate structural and chemical three-dimensional images of native skin. We employed SRS microscopy to investigate the microanatomical features of skin and penetration of topically applied materials. Image depth stacks are collected at distinct waveleng...
not_relevant
0
train
abstract
1,009
1,982,286
RUNX1 is downregulated or mutated in TLX1 T-ALL.
Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL
The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to decipher the oncogenic regulatory circuit controlled by TLX1 and TLX3. This systems biology analysis defined T cell ...
The TLX1 and TLX3 transcription factor oncogenes have a key role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). Here we used reverse engineering of global transcriptional networks to decipher the oncogenic regulatory circuit controlled by TLX1 and TLX3. This systems biology analysis defined T cell ...
relevant
1
train
abstract
1,009
37,895,688
RUNX1 is downregulated or mutated in TLX1 T-ALL.
"Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype.
In the spleens of young, adult mice there exist naturally occurring killer lymphocytes with specificity for mouse Moloney leukemia cells. The lytic activity was directed against syngeneic or allogeneic Moloney leukemia cells to a similar extent, but was primarily expressed when tested against in vitro grown leukemia ce...
In the spleens of young, adult mice there exist naturally occurring killer lymphocytes with specificity for mouse Moloney leukemia cells. The lytic activity was directed against syngeneic or allogeneic Moloney leukemia cells to a similar extent, but was primarily expressed when tested against in vitro grown leukemia ce...
not_relevant
0
train
abstract
1,009
12,315,072
RUNX1 is downregulated or mutated in TLX1 T-ALL.
Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.
At the cellular level, development progresses through successive regulatory states, each characterized by their specific gene expression profile. However, the molecular mechanisms regulating first the priming and then maintenance of gene expression within one developmental pathway are essentially unknown. The hematopoi...
At the cellular level, development progresses through successive regulatory states, each characterized by their specific gene expression profile. However, the molecular mechanisms regulating first the priming and then maintenance of gene expression within one developmental pathway are essentially unknown. The hematopoi...
not_relevant
0
train
abstract
1,011
9,745,001
Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.
Radioiodine treatment of multinodular non-toxic goitre.
OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. DESIGN Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed for a minimum of 12 months (median 48 months) after an in...
OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. DESIGN Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed for a minimum of 12 months (median 48 months) after an in...
relevant
1
train
abstract
1,011
1,173,667
Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.
Ranking of elimination feasibility between malaria-endemic countries
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these factors were assembled for all malaria-endemic countries and combined to provide an objective, relati...
Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these factors were assembled for all malaria-endemic countries and combined to provide an objective, relati...
not_relevant
0
train
abstract
1,011
26,026,009
Radioiodine treatment of non-toxic multinodular goitre increases thyroid volume.
Magnetic resonance imaging for volume estimation of large multinodular goitres: a comparison with scintigraphy.
As a result of increasing interest in non-surgical treatment for the reduction of goitre size the use of magnetic resonance (MR) imaging for volume estimation of large multinodular goitres was evaluated in 20 patients (three males and 17 females; age 61 +/- 21 years) with a multinodular goitre larger than 100 ml. In ad...
As a result of increasing interest in non-surgical treatment for the reduction of goitre size the use of magnetic resonance (MR) imaging for volume estimation of large multinodular goitres was evaluated in 20 patients (three males and 17 females; age 61 +/- 21 years) with a multinodular goitre larger than 100 ml. In ad...
not_relevant
0
train
abstract
1,015
6,277,638
Rapamycin delays aging in fruit flies.
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway, TOR kinase, is the target of the inhibitory drug rapamycin, a highly specific and well-describ...
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway, TOR kinase, is the target of the inhibitory drug rapamycin, a highly specific and well-describ...
relevant
1
train
abstract
1,015
11,630,388
Rapamycin delays aging in fruit flies.
Body-mass index and mortality in Korean men and women.
BACKGROUND Obesity is associated with diverse health risks, but the role of body weight as a risk factor for death remains controversial. METHODS We examined the association between body weight and the risk of death in a 12-year prospective cohort study of 1,213,829 Koreans between the ages of 30 and 95 years. We exami...
BACKGROUND Obesity is associated with diverse health risks, but the role of body weight as a risk factor for death remains controversial. METHODS We examined the association between body weight and the risk of death in a 12-year prospective cohort study of 1,213,829 Koreans between the ages of 30 and 95 years. We exami...
not_relevant
0
train
abstract
1,015
16,693,950
Rapamycin delays aging in fruit flies.
Replicative aging in yeast: the means to the end.
Progress in aging research is now rapid, and surprisingly, studies in a single-celled eukaryote are a driving force. The genetic modulators of replicative life span in yeast are being identified, the molecular events that accompany aging are being discovered, and the extent to which longevity pathways are conserved bet...
Progress in aging research is now rapid, and surprisingly, studies in a single-celled eukaryote are a driving force. The genetic modulators of replicative life span in yeast are being identified, the molecular events that accompany aging are being discovered, and the extent to which longevity pathways are conserved bet...
not_relevant
0
train
abstract
1,016
6,277,638
Rapamycin increases the concentration of triacylglycerols in fruit flies.
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway, TOR kinase, is the target of the inhibitory drug rapamycin, a highly specific and well-describ...
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway, TOR kinase, is the target of the inhibitory drug rapamycin, a highly specific and well-describ...
relevant
1
train
abstract
1,016
14,479,433
Rapamycin increases the concentration of triacylglycerols in fruit flies.
Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis
Neonatal cholestasis is a potentially life-threatening condition requiring prompt diagnosis. Mutations in several different genes can cause progressive familial intrahepatic cholestasis, but known genes cannot account for all familial cases. Here we report four individuals from two unrelated families with neonatal chol...
Neonatal cholestasis is a potentially life-threatening condition requiring prompt diagnosis. Mutations in several different genes can cause progressive familial intrahepatic cholestasis, but known genes cannot account for all familial cases. Here we report four individuals from two unrelated families with neonatal chol...
not_relevant
0
train
abstract
1,016
2,266,471
Rapamycin increases the concentration of triacylglycerols in fruit flies.
MicroRNA-21 is Induced by Rapamycin in a Model of Tuberous Sclerosis (TSC) and Lymphangioleiomyomatosis (LAM)
Lymphangioleiomyomatosis (LAM), a multisystem disease of women, is manifest by the proliferation of smooth muscle-like cells in the lung resulting in cystic lung destruction. Women with LAM can also develop renal angiomyolipomas. LAM is caused by mutations in the tuberous sclerosis complex genes (TSC1 or TSC2), resulti...
Lymphangioleiomyomatosis (LAM), a multisystem disease of women, is manifest by the proliferation of smooth muscle-like cells in the lung resulting in cystic lung destruction. Women with LAM can also develop renal angiomyolipomas. LAM is caused by mutations in the tuberous sclerosis complex genes (TSC1 or TSC2), resulti...
not_relevant
0
train
abstract
1,018
11,603,066
Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.
Using Structural Information to Change the Phosphotransfer Specificity of a Two-Component Chemotaxis Signalling Complex
Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component pathways, and the specificity of the phosphotransfer reactions within...
Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. Some bacteria have over 150 different two-component pathways, and the specificity of the phosphotransfer reactions within...
relevant
1
train
abstract
1,018
21,746,539
Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.
T-cell-antigen recognition and the immunological synapse
Much excitement of the past five years in the area of T-cell-antigen recognition has centred around the immunological synapse — a complex cellular structure that forms at the interface of a T cell and a cell that expresses the appropriate peptide–MHC complexes. Thanks to new imaging technologies, we are now beginning t...
Much excitement of the past five years in the area of T-cell-antigen recognition has centred around the immunological synapse — a complex cellular structure that forms at the interface of a T cell and a cell that expresses the appropriate peptide–MHC complexes. Thanks to new imaging technologies, we are now beginning t...
not_relevant
0
train
abstract
1,018
1,225,513
Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity.
Specificity Residues Determine Binding Affinity for Two-Component Signal Transduction Systems
UNLABELLED Two-component systems (TCS) comprise histidine kinases and their cognate response regulators and allow bacteria to sense and respond to a wide variety of signals. Histidine kinases (HKs) phosphorylate and dephosphorylate their cognate response regulators (RRs) in response to stimuli. In general, these reacti...
UNLABELLED Two-component systems (TCS) comprise histidine kinases and their cognate response regulators and allow bacteria to sense and respond to a wide variety of signals. Histidine kinases (HKs) phosphorylate and dephosphorylate their cognate response regulators (RRs) in response to stimuli. In general, these reacti...
not_relevant
0
train
abstract
1,023
16,927,286
Recognition of start codons depends on the translation initiation factor IF3.
Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation
In bacterial translational initiation, three initiation factors (IFs 1-3) enable the selection of initiator tRNA and the start codon in the P site of the 30S ribosomal subunit. Here, we report 11 single-particle cryo-electron microscopy (cryoEM) reconstructions of the complex of bacterial 30S subunit with initiator tRN...
In bacterial translational initiation, three initiation factors (IFs 1-3) enable the selection of initiator tRNA and the start codon in the P site of the 30S ribosomal subunit. Here, we report 11 single-particle cryo-electron microscopy (cryoEM) reconstructions of the complex of bacterial 30S subunit with initiator tRN...
relevant
1
train
abstract
1,023
22,521,091
Recognition of start codons depends on the translation initiation factor IF3.
NRAGE promotes the malignant phenotype of hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is a fatal disease, primarily due to the limited effective therapies available for patients with advanced or recurrent stages of the disease. Therefore, in order to improve patient prognosis, it is important to identify an informative biomarker for HCC progression, as well as a molecular ...
Hepatocellular carcinoma (HCC) is a fatal disease, primarily due to the limited effective therapies available for patients with advanced or recurrent stages of the disease. Therefore, in order to improve patient prognosis, it is important to identify an informative biomarker for HCC progression, as well as a molecular ...
not_relevant
0
train
abstract
1,023
39,729,277
Recognition of start codons depends on the translation initiation factor IF3.
Sequence features surrounding the translation initiation sites assigned on the genome sequence of Synechocystis sp. strain PCC6803 by amino-terminal protein sequencing.
To characterize the sequence features surrounding the translation initiation sites on the genome of Synechocystis sp. strain 6803, the total proteins extracted from the cell were resolved by two-dimensional electrophoresis, and the amino-terminal sequences of the relatively abundant protein spots were determined. By co...
To characterize the sequence features surrounding the translation initiation sites on the genome of Synechocystis sp. strain 6803, the total proteins extracted from the cell were resolved by two-dimensional electrophoresis, and the amino-terminal sequences of the relatively abundant protein spots were determined. By co...
not_relevant
0
train
abstract
1,025
32,408,470
Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo
Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia. However, the mechanisms behind these effects are unclear. Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase α2 ...
Cigarette smoking promotes body weight reduction in humans while paradoxically also promoting insulin resistance (IR) and hyperinsulinemia. However, the mechanisms behind these effects are unclear. Here we show that nicotine, a major constituent of cigarette smoke, selectively activates AMP-activated protein kinase α2 ...
relevant
1
train
abstract
1,025
471,921
Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.
Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association.
Air pollution is a heterogeneous, complex mixture of gases, liquids, and particulate matter. Epidemiological studies have demonstrated a consistent increased risk for cardiovascular events in relation to both short- and long-term exposure to present-day concentrations of ambient particulate matter. Several plausible me...
Air pollution is a heterogeneous, complex mixture of gases, liquids, and particulate matter. Epidemiological studies have demonstrated a consistent increased risk for cardiovascular events in relation to both short- and long-term exposure to present-day concentrations of ambient particulate matter. Several plausible me...
not_relevant
0
train
abstract
1,025
4,854,076
Reduced levels of lipolysis leads to higher P38 phosphorylation in adipose tissue.
The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment.
The rising incidence of obesity and associated metabolic diseases has increased the urgency in understanding all aspects of adipose tissue biology. This includes the function of adipocytes, how adipose tissue expands in obesity, and how expanded adipose tissues in adults can impact physiology. Here, we highlight the gr...
The rising incidence of obesity and associated metabolic diseases has increased the urgency in understanding all aspects of adipose tissue biology. This includes the function of adipocytes, how adipose tissue expands in obesity, and how expanded adipose tissues in adults can impact physiology. Here, we highlight the gr...
not_relevant
0
train
abstract
1,026
3,113,630
Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.
Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia
Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promotes neurodegeneration. Nuclear HDAC4 binds to chromatin, as well as to myocyte enha...
Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promotes neurodegeneration. Nuclear HDAC4 binds to chromatin, as well as to myocyte enha...
relevant
1
train
abstract
1,026
8,596,837
Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.
Sympathetic neural and cardiovascular responses during static handgrip exercise in women with a history of hypertensive pregnancy
Women with a history of hypertensive pregnancy are at greater risk for future cardiovascular events; however, the mechanisms for this increased risk are unknown. Evidence suggests that an exercise stimulus unmasks latent hypertensive tendencies, identifying individuals at the greatest risk for developing cardiovascular...
Women with a history of hypertensive pregnancy are at greater risk for future cardiovascular events; however, the mechanisms for this increased risk are unknown. Evidence suggests that an exercise stimulus unmasks latent hypertensive tendencies, identifying individuals at the greatest risk for developing cardiovascular...
not_relevant
0
train
abstract
1,026
22,185,730
Reduced phosphorylation of PP2A increases HDAC4 dephosphorylation by enhancing PP2A-HDAC4 interaction.
PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.
Abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of protein phosphatase 2A (PP2A), the major tau phosphatase in human brain, contributes to tau hyperphosphorylation in AD. However, the effects of PP2A ...
Abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of protein phosphatase 2A (PP2A), the major tau phosphatase in human brain, contributes to tau hyperphosphorylation in AD. However, the effects of PP2A ...
not_relevant
0
train
abstract
1,027
3,113,630
Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.
Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia-telangiectasia
Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promotes neurodegeneration. Nuclear HDAC4 binds to chromatin, as well as to myocyte enha...
Ataxia telangiectasia is a neurodegenerative disease caused by mutation of the Atm gene. Here we report that ataxia telangiectasia mutated (ATM) deficiency causes nuclear accumulation of histone deacetylase 4 (HDAC4) in neurons and promotes neurodegeneration. Nuclear HDAC4 binds to chromatin, as well as to myocyte enha...
relevant
1
train
abstract
1,027
11,459,139
Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.
Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity
INTRODUCTION Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mechanisms underlying this are not known. Nitric oxide (NO) inhibits WPB exocytosis, and bioavailabili...
INTRODUCTION Angiopoietin-2 (ang-2), an angiogenic peptide released by endothelial cell Weibel-Palade bodies (WPBs), increases endothelial activation and vascular permeability. Ang-2 is raised in severe sepsis but the mechanisms underlying this are not known. Nitric oxide (NO) inhibits WPB exocytosis, and bioavailabili...
not_relevant
0
train
abstract
1,027
22,185,730
Reduced phosphorylation of PP2A suppresses HDAC4 dephosphorylation.
PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.
Abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of protein phosphatase 2A (PP2A), the major tau phosphatase in human brain, contributes to tau hyperphosphorylation in AD. However, the effects of PP2A ...
Abnormal hyperphosphorylation of tau appears to be crucial in neurofibrillary degeneration in Alzheimer's disease (AD). Previous studies suggest that a down-regulation of protein phosphatase 2A (PP2A), the major tau phosphatase in human brain, contributes to tau hyperphosphorylation in AD. However, the effects of PP2A ...
not_relevant
0
train
abstract
1,028
11,899,391
Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.
Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory responses when compared with nondiseased, control individuals. Treg dysfunction cou...
Numerous reports have demonstrated that CD4(+)CD25(+) regulatory T cells (Tregs) from individuals with a range of human autoimmune diseases, including type 1 diabetes, are deficient in their ability to control autologous proinflammatory responses when compared with nondiseased, control individuals. Treg dysfunction cou...
relevant
1
train
abstract
1,028
13,923,140
Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity
Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with differential expression of the key immunoregulatory cytokine interleukin-2 (IL-2). In order to tes...
Autoimmune diseases are thought to result from imbalances in normal immune physiology and regulation. Here, we show that autoimmune disease susceptibility and resistance alleles on mouse chromosome 3 (Idd3) correlate with differential expression of the key immunoregulatory cytokine interleukin-2 (IL-2). In order to tes...
relevant
1
train
abstract
1,028
696,006
Reduced responsiveness to interleukin-2 in regulatory T cells is associated with autoimmune diseases such as Type 1 Diabetes.
Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
Patients with asthma, a major public health problem, are at high risk for serious disease from influenza virus infection, but the pathogenic mechanisms by which influenza A causes airway disease and asthma are not fully known. We show here in a mouse model that influenza infection acutely induced airway hyper-reactivit...
Patients with asthma, a major public health problem, are at high risk for serious disease from influenza virus infection, but the pathogenic mechanisms by which influenza A causes airway disease and asthma are not fully known. We show here in a mouse model that influenza infection acutely induced airway hyper-reactivit...
not_relevant
0
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SciFact Evidence Relevance Pairs

Custom (claim, document, label) pairs derived from BEIR SciFact for binary evidence relevance classification: given a scientific claim and a candidate paper field, decide whether the paper is relevant evidence for the claim.

This dataset accompanies the scifact-relevance-classifier project, built as the Lab 3 / Assignment 1 deliverable for Information Retrieval 5LN712 (Master's in Language Technology, Uppsala University, 2026).

Quick start

from datasets import load_dataset

# Three configs (one per document field variant)
ds = load_dataset("andreiaalexa/scifact-relevance-pairs", "title_abstract")
ds["train"][0]
# {
#   "claim": "...", "title": "...", "abstract": "...",
#   "document_text": "...", "label": "relevant", "label_id": 1, ...
# }

Configurations

Config Document field used Train Test Total
title only the paper title 2,537 939 3,476
abstract only the abstract 2,537 939 3,476
title_abstract "{title}. {abstract}" 2,537 939 3,476

Class balance is approximately 64% not_relevant / 36% relevant in both splits.

How it was built

BEIR SciFact (Wadden et al., 2020) is originally a retrieval benchmark — each claim has one or more abstracts marked as evidence. This dataset converts that into a classification task by emitting one row per (claim, candidate-document) pair:

  • Positives: every (claim, doc) pair that appears in the BEIR qrels for that claim.
  • Negatives: a mix of two kinds, sampled per claim with random_state=42:
    • Random negatives (~2 per positive) — sampled uniformly from the corpus, excluding the claim's known positives. Teaches broad non-relevance.
    • TF-IDF hard negatives (~2 per positive) — top-similarity documents to the claim by TF-IDF cosine, excluding known positives. Teaches the model not to rely on lexical overlap alone. Same family of technique as the BM25 hard negatives in DPR (Karpukhin et al., 2020).

The construction script lives at scifact_dataset.py in the GitHub repo and is fully deterministic given the same seed.

Columns

Column Type Description
split string train or test (matches BEIR's split). Redundant with the HF split but kept for traceability.
field_variant string Which field is used for document_text in this config (title, abstract, or title_abstract).
query_id string BEIR query id.
doc_id string BEIR corpus doc id.
claim string The scientific claim text.
title string Document title (always populated for traceability).
abstract string Document abstract (always populated for traceability).
document_text string The exact text the classifier sees, depending on field_variant.
label string relevant or not_relevant.
label_id int 1 for relevant, 0 for not_relevant.

Intended use

  • Training and benchmarking small embedding-based classifiers for scientific evidence retrieval / re-ranking.
  • Educational use illustrating: (a) converting a retrieval benchmark into a classification dataset, (b) the role of hard-negative mining, (c) ablations across input field choices.

Out-of-scope use

  • This dataset is not suitable for clinical decision-making or any high-stakes scientific judgment. Labels are derived from BEIR qrels, which are themselves expert annotations on a small biomedical claim set; they do not generalise to arbitrary scientific domains.
  • Predictions from models trained on this dataset should be treated as a first-pass relevance signal, not as ground truth about scientific evidence quality.

License

MIT, matching the source code repository. The underlying SciFact corpus and qrels are released under CC BY-NC 2.0 by AI2 — please cite Wadden et al. (2020) when using this dataset.

Citations

If you use this dataset, please cite both the original SciFact paper and (optionally) this project:

@inproceedings{wadden-etal-2020-fact,
    title = "Fact or Fiction: Verifying Scientific Claims",
    author = "Wadden, David  and  Lin, Shanchuan  and  Lo, Kyle  and
              Wang, Lucy Lu  and  van Zuylen, Madeleine  and
              Cohan, Arman  and  Hajishirzi, Hannaneh",
    booktitle = "Proceedings of the 2020 Conference on Empirical Methods in Natural Language Processing (EMNLP)",
    year = "2020",
    url = "https://aclanthology.org/2020.emnlp-main.609/",
}

@inproceedings{thakur-etal-2021-beir,
    title = "{BEIR}: A Heterogeneous Benchmark for Zero-shot Evaluation of Information Retrieval Models",
    author = "Thakur, Nandan and Reimers, Nils and R{\"u}ckl{\'e}, Andreas and Srivastava, Abhishek and Gurevych, Iryna",
    booktitle = "NeurIPS 2021 Datasets and Benchmarks Track",
    year = "2021",
    url = "https://arxiv.org/abs/2104.08663",
}

Acknowledgements

Built with Hugging Face Datasets and scikit-learn. Course taught by Birger Moëll at Uppsala University.

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