id stringclasses 1
value | instruction stringlengths 112 253 | input stringlengths 58 302 | output stringlengths 0 5.77k |
|---|---|---|---|
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Access microbiology says. | What does the article say about A case of pleural Mycobacterium tuberculosis infection with reversion of Quantiferon Gold Plus results from positive to negative.? | Introduction. Mycobacterium tuberculosis (MTB) infections continue to have a high mortality and morbidity burden globally. Interferon-gamma release assays such as Quantiferon Gold Plus (QFG-Plus) aid in diagnosis of latent TB but diagnosis of pleural TB remains challenging. We present a case of active pleural MTB infec... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Tuberculosis (Edinburgh, Scotland) says. | What does the article say about Uncharted territory: the role of mitochondrial DNA variation in macrophage-mediated host susceptibility to tuberculosis.? | Mitochondria form an integral, yet frequently underappreciated, part of the immune response to Mycobacterium tuberculosis (M.tb), particularly within macrophages. Despite growing recognition for their role in infection and immunity, studies investigating how mitochondrial DNA (mtDNA) variation influences host susceptib... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what medRxiv : the preprint server for health sciences says. | What does the article say about Tongue Swab Xpert MTB/RIF Ultra Testing for Tuberculosis Using a Revised Consensus Protocol: A multi-country diagnostic accuracy study.? | Tongue swabs are a promising specimen for tuberculosis (TB) diagnosis. In a previous study using a consensus protocol, tongue swabs tested with Xpert MTB/RIF Ultra (Xpert Ultra, Cepheid, USA) outperformed sputum smear microscopy, but a substantial proportion (6.1%) of results were non-actionable (e.g., invalid/error). ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Infectious diseases says. | What does the article say about The participation of people deprived of liberty in tuberculosis vaccine trials: should they be protected from research, or through research?? | People deprived of liberty are among the populations experiencing the highest rates of tuberculosis. Prisons typically create ideal conditions for Mycobacterium tuberculosis transmission, including overcrowding and prolonged exposure in poorly ventilated environments, and often have populations at high risk of developi... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Microbiology spectrum says. | What does the article say about Contamination rates in serially sampled sputum specimens obtained during tuberculosis treatment to capture culture conversion.? | Sputum cultures are the gold standard for tuberculosis (TB) diagnosis and treatment monitoring. However, cultures in MGIT liquid media are susceptible to microbial contamination, often rendering them uninterpretable. Research has shown that maintaining strict cold chains and supervised sample collection can reduce cont... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Infectious disease reports says. | What does the article say about Drug-Resistant Tuberculosis Hotspots in Oliver Reginald Tambo District Municipality, Eastern Cape, South Africa.? | The global push to eliminate tuberculosis (TB) as a public health threat is increasingly urgent, particularly in high-burden areas like the Oliver Reginald Tambo District Municipality, South Africa. Drug-resistant TB (DR-TB) poses a significant challenge to TB control efforts and is a leading cause of TB-related deaths... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what International journal of environmental research and public health says. | What does the article say about Knowledge and Prevalence of Latent Tuberculosis Infection: A Feasibility and Pilot Study in a Primary Healthcare Setting in Rural Eastern Cape, South Africa.? | Latent tuberculosis infection (LTBI) remains a significant global health concern, particularly in regions with high tuberculosis (TB) prevalence, such as South Africa. This pilot study aimed to evaluate the prevalence of LTBI and assess patient knowledge about the condition in a primary healthcare clinic in rural Easte... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Frontiers in immunology says. | What does the article say about Immunomodulatory effects of atorvastatin on peripheral blood mononuclear cells infected with <i>Mycobacterium tuberculosis</i>.? | Tuberculosis (TB) remains a major global health threat, contributing substantially to high morbidity and mortality rates. This underscores the urgent need for more effective interventions. Recent studies highlight the potential of host-directed therapy approaches to enhance immune defences against TB. Atorvastatin, rec... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what PLOS global public health says. | What does the article say about Strong effect of demographic changes on Tuberculosis susceptibility in South Africa.? | South Africa is among the world's top eight tuberculosis (TB) burden countries, and despite a focus on HIV-TB co-infection, most of the population living with TB are not HIV co-infected. The disease is endemic across the country, with 80-90% exposure by adulthood. We investigated epidemiological risk factors for (TB) i... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Clinical pharmacology and therapeutics says. | What does the article say about Model-Informed Once-Daily Dosing Strategy for Bedaquiline and Delamanid in Children, Adolescents and Adults with Tuberculosis.? | The complexity of the currently registered dosing schedules for bedaquiline and delamanid is a barrier to uptake in drug-resistant tuberculosis treatment across all ages. A simpler once-daily dosing schedule is critical to ensure patient-friendly regimens with good adherence. We assessed expected drug exposures with pr... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Journal of antimicrobial chemotherapy says. | What does the article say about Population pharmacokinetics and exposure-response relationship of the antituberculosis drug BTZ-043.? | BTZ-043 is a first-in-class benzothiazinone for the treatment of TB with demonstrated early bactericidal activity. BTZ-043 is metabolized into two major metabolites: M1 and M2. The aim of this study was to characterize the pharmacokinetics (PK) and early exposure-response (pharmacokinetic/pharmacodynamic, PK/PD) relati... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what medRxiv : the preprint server for health sciences says. | What does the article say about USING SPUTUM AND TONGUE SWAB SPECIMENS FOR IN-HOME POINT-OF-CARE TARGETED UNIVERSAL TESTING FOR TB OF HOUSEHOLD CONTACTS: AN ACCEPTABILITY AND FEASIBILITY ANALYSIS.? | Effective strategies are needed to facilitate early detection and diagnosis of tuberculosis (TB). The overreliance on passive case detection, symptom screening, and collection of sputum, results in delayed or undiagnosed TB, which directly contributes to on-going TB transmission. We assessed the acceptability and feasi... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what bioRxiv : the preprint server for biology says. | What does the article say about Protein Kinase C δ: a critical hub regulating macrophage immunomodulatory functions during <i>Mycobacterium tuberculosis</i> infection.? | A host-modulating candidate gene involved in putative pathogen-killing pathways, with potential novel therapeutic intervention, Protein Kinase C - δ (PKCδ) has been recognized as a critical marker of inflammation with clinical and experimental evidence in recent years. Pulmonary microenvironment during Mtb infection is... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what ACS infectious diseases says. | What does the article say about Immunomodulatory Nanoparticles Induce Autophagy in Macrophages and Reduce <i>Mycobacterium tuberculosis</i> Burden in the Lungs of Mice.? | Tuberculosis (TB) is the leading cause of death from infectious disease. Macrophages are the primary immune responders and become the primary host cells for the causative agent Mycobacterium tuberculosis . Following the uptake of M. tuberculosis , the inherent antimicrobial action of macrophages is dampened, enabling t... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Iranian biomedical journal says. | What does the article say about Anti-Inflammatory, Cytotoxic, and Anti-Tuberculosis Properties of Selected Fabaceae Medicinal Plants through in vitro Studies.? | Tuberculosis (TB) is among the top ten causes of death in South Africa and worldwide and remains a high priority of the World Health Organization. South Africa has a rich tradition for using medicinal plants to treat various diseases, including TB; however, the safety and efficacy of these plants require thorough inves... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what IJTLD open says. | What does the article say about Lung function trajectories in children with pulmonary TB and non-TB lower respiratory tract infections.? | This longitudinal study compared lung function in children with pulmonary TB (PTB), children with non-TB lower respiratory tract infections (LRTIs) and healthy controls. Children aged 4-13 years presenting with presumed PTB and their healthy siblings who could perform spirometry were included. Children were classified ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Journal of infectious diseases says. | What does the article say about Impact of Puberty on Immune Responses to Mycobacterium tuberculosis in South African Adolescents.? | As individuals progress through adolescence, their risk of tuberculosis (TB) increases, and the type of disease that develops changes, with increasing cavitary formation and parenchymal tissue destruction. While it is widely assumed that the changes in risk and disease phenotype are due to puberty exerting an impact on... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Journal of infection says. | What does the article say about Baseline and end-of-treatment host serum biomarkers predict relapse in adults with pulmonary tuberculosis.? | There is a need for new tools for monitoring of the response to TB treatment. Such tools may allow for tailored treatment regimens, and stratify patients initiating TB treatment into different risk groups. We evaluated combinations between previously published host biomarkers and new candidates, as tools for monitoring... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Journal of public health in Africa says. | What does the article say about Policy analysis: Key milestones in MDR-TB management over the past decade in South Africa.? | Significant strides have been made globally and in South Africa (SA) in the policy and biomedical management of multidrug-resistant tuberculosis (MDR-TB). However, MDR-TB remains a significant public health threat. This policy content analysis aims to explore the key milestones in MDR-TB management in SA and globally o... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what IJTLD open says. | What does the article say about Patient and provider preferences for long-acting TB preventive therapy.? | Tuberculosis preventive therapy (TPT) is critical for TB elimination but is underutilised. Long-acting (LA) TPT can potentially improve linkage to care, treatment adherence and outcomes. We conducted a cross-sectional in-person survey in two high TB burden countries to evaluate preferences and concerns about LA formula... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Molecules (Basel, Switzerland) says. | What does the article say about Synthesis, Characterisation, Biological Evaluation and In Silico Studies of Quinoline-1,2,3-Triazole-Anilines as Potential Antitubercular and Anti-HIV Agents.? | HIV/AIDS and Mycobacterial tuberculosis ( Mtb ) are the leading cause of deaths worldwide. Thus, better medicaments are required to manage these diseases. Quinolines have shown great potential due to their broad spectrum of biological activity. Thus, quinoline-1,2,3-triazole-aniline hybrids were synthesised in moderate... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Clinical infectious diseases : an official publication of the Infectious Diseases Society of America says. | What does the article say about Optimal Timing to Discontinue Respiratory Isolation Among Patients With Pulmonary Tuberculosis.? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Journal of chromatography. B, Analytical technologies in the biomedical and life sciences says. | What does the article say about Development and validation of an LC-MS/MS multiplex assay for the quantification of bedaquiline, n-desmethyl bedaquiline, linezolid, levofloxacin, and clofazimine in dried blood spots.? | Dried blood spot (DBS) assays to quantify novel and repurposed drugs for the treatment of rifampicin-resistant tuberculosis (RR-TB) would facilitate pharmacokinetic studies and therapeutic drug monitoring in low-middle income settings, considering their ease of application and simple sample storage requirements. We des... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Journal of hand surgery, European volume says. | What does the article say about Syringomyelia-induced wrist Charcot neuroarthropathy.? | We present a rare case of wrist Charcot neuroarthropathy secondary to post-tuberculosis syringomyelia. Level of evidence: V. | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Journal of infectious diseases says. | What does the article say about Review of Current Tuberculosis Human Infection Studies for Use in Accelerating Tuberculosis Vaccine Development: A Meeting Report.? | Tools to evaluate and accelerate tuberculosis (TB) vaccine development are needed to advance global TB control strategies. Validated human infection studies for TB have the potential to facilitate breakthroughs in understanding disease pathogenesis, identify correlates of protection, develop diagnostic tools, and accel... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease says. | What does the article say about Risk factors for and timing of presumptive recurrent TB.? | INTRODUCTION Understanding factors associated with increased risk for tuberculosis (TB) recurrence is essential in lowering the TB burden. We aimed to quantify the burden, risk factors, and timing of TB presumptive recurrence. METHODS We analyzed test results from 2013 to 2017 in the South African National Health Labor... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Child & adolescent health says. | What does the article say about Mycobacterium tuberculosis infection and tuberculosis disease in the first decade of life: a South African birth cohort study.? | Paediatric tuberculosis leads to more than 200 000 deaths annually. We aimed to investigate the incidence of Mycobacterium tuberculosis infection and tuberculosis disease in the first decade of life in the Drakenstein Child Health Study (DCHS), a South African cohort in a community with high tuberculosis and HIV incide... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases says. | What does the article say about Diagnostic accuracy of self-collected tongue swabs for Mycobacterium tuberculosis complex detection in individuals being assessed for tuberculosis in South Africa using the Xpert MTB/RIF Ultra assay.? | Tongue swabs (TS) have shown potential for detecting Mycobacterium tuberculosis complex (MTBC) through downstream molecular testing. Analytical performance varies, depending on the processing protocol and the molecular test used. This study aimed to first investigate the ease of use of TS collection in addition to acce... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Research square says. | What does the article say about A new rapid lipoarabinomannan urine assay for tuberculosis: a two-centre diagnostic accuracy evaluation in outpatients with and without HIV.? | Non-sputum tests for people attending primary care with symptoms of tuberculosis (TB) are a global priority. We performed a cross-sectional two-centre diagnostic accuracy study of a next-generation urine lipoarabinomannan assay (Biopromic TB LAM, BP-LAM) and the lateral flow Determine TB LAM Ag assay (LF-LAM) on urine ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what EClinicalMedicine says. | What does the article say about A scoping review of interventions to address TB associated respiratory disability.? | There is a growing body of data describing a high burden of respiratory morbidity amongst pulmonary TB patients and survivors, with up to half thought to experience residual respiratory symptoms, abnormal spirometry, or structural pathology after TB treatment completion. Many patients experiencing marked impacts on the... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease says. | What does the article say about Successful rechallenge of rifabutin in rifampicin-induced thrombocytopenia during TB treatment.? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Southern African journal of HIV medicine says. | What does the article say about Blood and urine early treatment response biomarkers in HIV-associated disseminated tuberculosis.? | Treatment response biomarkers are needed in the care of patients hospitalised with HIV-associated tuberculosis (TB). We describe the changes in bacillary load during early treatment using quantitative and semi-quantitative measures of Mycobacterium tuberculosis in blood and urine. We collected serial blood and urine sa... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Clinical infectious diseases : an official publication of the Infectious Diseases Society of America says. | What does the article say about Effectiveness of Double-Dose Dolutegravir in People Receiving Rifampin-based Tuberculosis Treatment: An Observational, Cohort Study of People With HIV From 6 Countries.? | Tenofovir-lamivudine-dolutegravir (TLD) is the preferred first-line antiretroviral therapy (ART) regimen. An additional 50-mg dose of dolutegravir (TLD+50) is required with rifampin-containing tuberculosis (TB) co-treatment. There are limited data on the effectiveness of TLD+50 in individuals with TB/human immunodefici... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases says. | What does the article say about Infection prevention and control measures during the COVID-19 pandemic and airborne tuberculosis transmission during primary care visits in South Africa.? | Tuberculosis (TB) transmission in crowded health care settings poses considerable risks in high-burden regions. We assessed how COVID-19 pandemic-related infection prevention and control (IPC) measures might impact TB transmission in a South African primary care clinic. In 2019 (prepandemic) and 2021 (pandemic), we col... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what International journal of environmental research and public health says. | What does the article say about Outcomes of Treating Tuberculosis Patients with Drug-Resistant Tuberculosis, Human Immunodeficiency Virus, and Nutritional Status: The Combined Impact of Triple Challenges in Rural Eastern Cape.? | Treatment outcomes are critical measures of TB treatment success, especially in resource-limited settings where tuberculosis remains a major public health issue. This study evaluated the treatment outcomes of patients with drug-resistant tuberculosis (DR-TB), co-infected with human immunodeficiency virus (HIV), and the... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Infectious diseases says. | What does the article say about Effects of conditional cash transfers and pre-test and post-test tuberculosis counselling on patient outcomes and loss to follow-up across the continuum of care in South Africa: a randomised controlled trial.? | Economic and behavioural factors lead to poor outcomes in patients with tuberculosis. We investigated the effects of a package of interventions consisting of pre-test and post-test tuberculosis counselling with conditional cash transfers on patient outcomes in adults undergoing investigation for pulmonary tuberculosis.... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Clinical infectious diseases : an official publication of the Infectious Diseases Society of America says. | What does the article say about Evaluation of C-Reactive Protein and Computer-Aided Analysis of Chest X-rays as Tuberculosis Triage Tests at Health Facilities in Lesotho and South Africa.? | To improve tuberculosis case-finding, rapid, non-sputum triage tests need to be developed according to the World Health Organization target product profile (TPP) (>90% sensitivity, >70% specificity). We prospectively evaluated and compared artificial intelligence-based, computer-aided detection software, CAD4TBv7, and ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Kidney360 says. | What does the article say about Think Kidney Function When Testing for and Treating Tuberculosis.? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Research square says. | What does the article say about HUMAN ALVEOLAR MACROPHAGE FUNCTION IS IMPAIRED IN TUBERCULOSIS CONTACTS WITH DIABETES.? | Type 2 diabetes (T2D) increases susceptibility to tuberculosis (TB) with the underlying mechanisms remaining unknown. To determine whether immune dysfunction in the lung contributes to TB susceptibility, we obtained paired human alveolar macrophages (HAMs) and monocyte-derived macrophages (MDMs) from TB-exposed individ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what PloS one says. | What does the article say about The TB vaccine clinical trial centre directory: An inventory of clinical trial centres in Sub-Saharan Africa.? | There are over ten vaccine candidates for tuberculosis (TB) in the clinical pipeline that require testing in TB-prevalent populations. To accelerate the clinical development of TB vaccines, a directory of clinical trial centres was established in sub-Saharan Africa (SSA) to assess capacity for conducting late-stage TB ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease says. | What does the article say about Experiences of key populations in multidrug-resistant TB and HIV.? | Key populations for multidrug-resistant TB (MDR-TB) face heightened vulnerability due to social, behavioral, and structural barriers, such as poverty, substance use and stigma. Here we illustrate the difficulties faced with a composite personal narrative based on the experiences of two participants in a clinical trial ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Tropical medicine and infectious disease says. | What does the article say about Time to Change": To What Extent Could Non-Sputum Sampling Accelerate the Fight Against Tuberculosis-A Qualitative Study Among End-Users.? | Inadequate access to timely diagnosis and linkage to treatment are major barriers to tuberculosis (TB) care. New point-of-care diagnostics that do not rely solely on sputum samples are needed to make up for lost time, bringing TB testing closer to service recipients and addressing current sputum sampling limitations. U... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Journal of antimicrobial chemotherapy says. | What does the article say about Cardiac safety of bedaquiline, delamanid and moxifloxacin co-administered with or without varying doses of sutezolid or delpazolid for the treatment of drug-susceptible TB.? | Many drugs for the treatment of TB prolong the QTc interval, which is associated with an increased risk of developing a life-threatening arrhythmia known as torsades de pointes. Sutezolid and delpazolid are novel oxazolidinones with demonstrated bactericidal activity. We aimed to assess the effects of sutezolid or delp... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what medRxiv : the preprint server for health sciences says. | What does the article say about Informing People-Centered Target Product Profiles for TB Diagnostics: A Multi-Country Qualitative Study.? | Timely and accurate tuberculosis (TB) diagnosis remains a key challenge in high-burden settings. The World Health Organization (WHO) has developed Target Product Profiles (TPPs) to guide diagnostic development, which have largely reflected the perspectives of experts, with limited input from people affected by TB. This... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The European respiratory journal says. | What does the article say about Collagen-targeted PET/CT imaging of tuberculosis patients.? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what EClinicalMedicine says. | What does the article say about Efficacy and safety of higher dose rifampicin in adults with presumed drug-susceptible tuberculosis: an updated systematic review and meta-analysis.? | Tuberculosis (TB) remains a significant cause of mortality globally, yet first-line treatment has hardly changed for fifty years. The dose of rifampicin, the most important drug in this regimen, has been historically based on pragmatic cost- and risk-benefit considerations. Evidence suggests the current recommended dos... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Infectious diseases says. | What does the article say about Delpazolid in combination with bedaquiline, delamanid, and moxifloxacin for pulmonary tuberculosis (PanACEA-DECODE-01): a prospective, randomised, open-label, phase 2b, dose-finding trial.? | Linezolid plays a crucial role in the first-line treatment of drug-resistant tuberculosis globally. Its prolonged use can lead to neurological and haematological toxicity, highlighting the need for safer oxazolidinones. Delpazolid, a novel oxazolidinone, might be safer. We aimed to evaluate the safety and efficacy of d... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Digital health says. | What does the article say about Computer-aided detection of tuberculosis from chest radiographs in a tuberculosis prevalence survey in South Africa: external validation and modelled impacts of commercially available artificial intelligence software.? | Computer-aided detection (CAD) can help identify people with active tuberculosis left undetected. However, few studies have compared the performance of commercially available CAD products for screening in high tuberculosis and high HIV settings, and there is poor understanding of threshold selection across products in ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Public health says. | What does the article say about Confronting the growing epidemic of silicosis and tuberculosis among small-scale miners.? | An estimated 49·5 million small-scale miners worldwide are exposed to high concentrations of silica during their work. The substantial morbidity and mortality of silicosis and tuberculosis among workers exposed to such intensities have been documented. This Viewpoint raises concern at the failure to respond to a growin... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Infectious diseases says. | What does the article say about Patient-centred approaches for drug-resistant tuberculosis - Authors' reply.? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Scientific reports says. | What does the article say about Immune, metabolic, anatomical, and functional features of people after successful tuberculosis treatment: an exploratory analysis.? | We explored the underlying mechanisms that may drive post-tuberculosis (TB) lung disease, a multifactorial, heterogenous, and prevalent disease. Extensive clinical phenotyping through fluorine-18 Fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) scans, pulmonary function testing, and ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Infection and drug resistance says. | What does the article say about Treatment Outcomes for Drug-Resistant Tuberculosis Patients on Bedaquiline-Based Regimens in a Mostly Rural South Africa.? | Tuberculosis (TB) has maintained its position as a leading global health crisis. The situation of DR-TB is exacerbated by the emergence of drug resistance, particularly rifampicin resistant TB (RR-TB), multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). Bedaquiline (BDQ) has now become part of all ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what IJTLD open says. | What does the article say about The risk of rifampicin-resistant TB after drug-susceptible TB treatment.? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease says. | What does the article say about BMI as a predictor of progression from TB infection to active TB in PLHIV.? | BACKGROUND Low body mass index (BMI) is a globally important risk factor for TB progression. Little is known about this association in people living with HIV (PLHIV) and the functional form of the BMI-TB incidence curve. METHODS Secondary analysis of a randomised controlled trial of TB preventive therapy among PLHIV in... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Pathogens (Basel, Switzerland) says. | What does the article say about Predicting Treatment Outcomes in Patients with Drug-Resistant Tuberculosis and Human Immunodeficiency Virus Coinfection, Using Supervised Machine Learning Algorithm.? | Drug-resistant tuberculosis (DR-TB) and HIV coinfection present a conundrum to public health globally and the achievement of the global END TB strategy in 2035. A descriptive, retrospective review of medical records of patients, who were diagnosed with DR-TB and received treatment, was conducted. Student's t -test was ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Infectious diseases says. | What does the article say about A clinical practice guideline for tuberculous meningitis.? | Tuberculous meningitis is the most severe form of tuberculosis, causing death or disability in around half of those affected. There are no up-to-date international guidelines defining its optimal management. Therefore, the Tuberculous Meningitis International Research Consortium conducted a systematic review of availab... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Global health says. | What does the article say about A successful UN High-Level Meeting on antimicrobial resistance must build on the 2023 UN High-Level Meeting on tuberculosis.? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what American journal of respiratory and critical care medicine says. | What does the article say about Oral Rinse versus Facemask Capture for Non-Sputum Diagnosis of Pulmonary Tuberculosis.? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Respiratory medicine says. | What does the article say about Post-tuberculosis lung disease: towards prevention, diagnosis, and care.? | There is a growing body of data describing the high burden of respiratory sequelae seen among tuberculosis survivors, including children, adolescents, and adults. This group of sequelae are known as post-tuberculosis lung disease and include parenchymal damage, airway disease, and pulmonary vascular disease. It is thou... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Current tropical medicine reports says. | What does the article say about Including the voice of children <15-years-old in paediatric global health research.? | Despite evidence of the benefits of including children's voices in global health research, they continue to be underrepresented. Implementation of how to include children's voices appears to remain an obstacle to their inclusion in global health research. In this manuscript, we present an epistemological frame that adv... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what EClinicalMedicine says. | What does the article say about High mortality among patients with tuberculosis accessing primary care facilities: secondary analysis from an open-label cluster-randomised trial.? | Tuberculosis (TB) mortality remains persistently high, despite global TB control efforts. The aim of this study was to assess if a quality improvement (QI) intervention reduced deaths in TB patients accessing primary healthcare (PHC) services. In this pre specified secondary analysis of a cluster-randomized controlled ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what BMC health services research says. | What does the article say about Is South Africa ready for point-of-care, non-sputum tests for TB diagnosis? An assessment of end-user perceptions on a novel urine test and tongue swab for TB testing.? | Sputum collection continues to limit TB testing, resulting in undiagnosed TB. Innovative interventions are needed to expand point-of-care TB diagnosis particularly in low-to-middle income countries (LMICs). Novel non-sputum sample types currently under development can increase TB testing, however there is limited knowl... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease says. | What does the article say about The hidden burden of miliary TB in children and adolescents.? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Metabolomics : Official journal of the Metabolomic Society says. | What does the article say about Metabolic insights into HIV/TB co-infection: an untargeted urinary metabolomics approach.? | Amid the global health crisis, HIV/TB co-infection presents significant challenges, amplifying the burden on patients and healthcare systems alike. Metabolomics offers an innovative window into the metabolic disruptions caused by co-infection, potentially improving diagnosis and treatment monitoring. This study uses un... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what IJTLD open says. | What does the article say about Clinical best practices for caring for people with expanded resistance to newer TB drugs.? | Strains of Mycobacterium tuberculosis with resistance to the new and repurposed drugs included in the all-oral shorter TB regimens recommended by WHO for the treatment of multidrug-resistant/rifampicin-resistant TB (MDR/RR-TB) are becoming increasingly common globally. When strains of M. tuberculosis have resistance to... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Clinical infectious diseases : an official publication of the Infectious Diseases Society of America says. | What does the article say about Clinical Outcomes in Children With Human Immunodeficiency Virus Treated for Nonsevere Tuberculosis in the SHINE Trial.? | Children with human immunodeficiency virus (HIV, CWH) are at high risk of tuberculosis (TB) and face poor outcomes, despite antiretroviral therapy (ART). We evaluated outcomes in CWH and children not living with HIV treated for nonsevere TB in the SHINE trial. SHINE was a randomized trial that enrolled children aged <1... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what JACC. Advances says. | What does the article say about Cardiovascular Involvement in Tuberculosis Patients Treated in Southern Africa.? | Tuberculosis (TB) is the leading cause of death among people with HIV and a major global health challenge. Subclinical cardiovascular manifestations of TB are poorly documented in high TB and HIV burden countries. The purpose of this study was to quantify the prevalence of cardiovascular involvement in TB patients and ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Pulmonary circulation says. | What does the article say about Scoping review of post-TB pulmonary vascular disease: Proceedings from the 2nd International Post-Tuberculosis Symposium.? | Tuberculosis (TB) may cause significant long-term cardiorespiratory complications, of which pulmonary vascular disease is most under-recognized. TB is rarely listed as a cause of pulmonary hypertension (PH) in most PH guidelines, yet PH may develop at various stages in the time course of TB, from active infection throu... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what BMC infectious diseases says. | What does the article say about Prior tuberculosis, radiographic lung abnormalities and prevalent diabetes in rural South Africa.? | Growing evidence suggests that chronic inflammation caused by tuberculosis (TB) may increase the incidence of diabetes. However, the relationship between post-TB pulmonary abnormalities and diabetes has not been well characterized. We analyzed data from a cross-sectional study in KwaZulu-Natal, South Africa, of people ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Open forum infectious diseases says. | What does the article say about Mental Health, Substance Use, and Tuberculosis Preventive Therapy in People With HIV: A Prospective Cohort Study.? | Because of the association of mental health and substance use disorders with higher HIV mortality and decreased retention in care, we investigated their frequency and impact on tuberculosis preventive therapy (TPT) adherence and completion among people with HIV (PWHIV) initiating TPT. We conducted a prospective, longit... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Journal of clinical microbiology says. | What does the article say about Host blood protein biomarkers to screen for tuberculosis disease: a systematic review and meta-analysis.? | Non-sputum tests are needed to improve tuberculosis (TB) diagnosis and close the diagnostic gap. The World Health Organization's target product profile (TPP) for point-of-care (POC) screening tests requires a minimum sensitivity of 90% and a specificity of 70%. Our objective was to identify host blood protein biomarker... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Tropical medicine and infectious disease says. | What does the article say about Application of Monoclonal Anti-Mycolate Antibodies in Serological Diagnosis of Tuberculosis.? | Patient loss to follow-up caused by centralised and expensive diagnostics that are reliant on sputum is a major obstacle in the fight to end tuberculosis. An affordable, non-sputum biomarker-based, point-of-care deployable test is needed to address this. Serum antibodies binding the mycobacterial cell wall lipids, myco... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what bioRxiv : the preprint server for biology says. | What does the article say about Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in <i>M. tuberculosis</i> host defense.? | Mycobacterium tuberculosis (Mtb) must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrophages by ACOD1 mediated decarboxylation of aconitate, has direct antimicrobial activity, modulates infl... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Microbiology spectrum says. | What does the article say about Modulation of riboflavin biosynthesis and utilization in mycobacteria.? | Riboflavin (vitamin B 2 ) is the precursor of the flavin coenzymes, FAD and FMN, which play a central role in cellular redox metabolism. While humans must obtain riboflavin from dietary sources, certain microbes, including Mycobacterium tuberculosis (Mtb), can biosynthesize riboflavin de novo . Riboflavin precursors ha... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Open forum infectious diseases says. | What does the article say about Utility of Cerebrospinal Fluid Unstimulated Interferon-Gamma (IRISA-TB) as a Same-Day Test for Tuberculous Meningitis in a Tuberculosis-Endemic, Resource-Poor Setting".? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Infectious Disease Modelling says. | What does the article say about Modelling the potential impact of TB-funded prevention programs on the transmission dynamics of TB.? | Tuberculosis (TB) continues to be a major global health challenge, with millions of new cases and deaths each year despite the massive efforts and funding put in the fight against the disease. In this paper, we develop a mathematical model to evaluate the impact of TB-funded prevention programs on the transmission dyna... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what EBioMedicine says. | What does the article say about Safety, reactogenicity, and immunogenicity of MTBVAC in infants: a phase 2a randomised, double-blind, dose-defining trial in a TB endemic setting.? | Safer and more effective tuberculosis (TB) vaccines than Bacille Calmette Guérin (BCG) are needed. We evaluated the safety, reactogenicity, and immunogenicity of three dose levels of the live-attenuated Mycobacterium tuberculosis (Mtb) vaccine, MTBVAC, compared to BCG, in South African infants. Healthy, HIV-unexposed, ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Health and quality of life outcomes says. | What does the article say about An item bank to measure health-related quality of life among young children (0-5-years-old) affected by respiratory illnesses - expert stakeholders and end-users from the Western Cape, South Africa.? | Health-related quality of life (HRQoL) is a crucial patient-centred outcome for developing policy. However, there is a lack of appropriate HRQoL measures for young children (0-5-years), who are particularly vulnerable to respiratory illnesses like pulmonary tuberculosis (PTB) and other respiratory infections, especiall... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Indian journal of pediatrics says. | What does the article say about Current Treatment of Drug-Resistant Tuberculosis in Children.? | Optimal diagnosis and management of children aged <15 y with rifampicin- or multidrug-resistant tuberculosis (RR/MDR-TB) relies on identification of adults with the disease and pro-active screening of their close contacts. Children may be diagnosed with RR/MDR-TB based on microbiological confirmation from clinical spec... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what BMJ open says. | What does the article say about Interventions to enhance corporate sector engagement in tuberculosis response in Africa: a scoping review protocol.? | Tuberculosis (TB) is a significant public health crisis in Africa. TB control programmes implemented by various state and non-state actors in different African countries over the years have recorded significant gains in the reduction of the incidence and prevalence of TB through the vehicle of private care provider eng... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases says. | What does the article say about Tuberculosis and HIV coinfection: Progress and challenges towards reducing incidence and mortality.? | HIV-associated tuberculosis (HIV-TB) is associated with disproportionate mortality: approximately 24% of the 660,000 individuals with TB and HIV died, compared to 11% of those without HIV dying from TB in 2023. HIV is a key driver of ongoing high TB incidence in many countries, particularly in the World Health Organiza... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Metabolomics : Official journal of the Metabolomic Society says. | What does the article say about Characterising the urinary acylcarnitine and amino acid profiles of HIV/TB co-infection, using LC-MS metabolomics.? | The human immunodeficiency virus (HIV) and tuberculosis (TB) co-infection presents significant challenges due to the complex interplay between these diseases, leading to exacerbated metabolic disturbances. Understanding these metabolic profiles is crucial for improving diagnostic and therapeutic approaches. This study ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Infectious diseases says. | What does the article say about Sequential and parallel testing for microbiological confirmation of tuberculosis disease in children in five low-income and middle-income countries: a secondary analysis of the RaPaed-TB study.? | Despite causing high mortality worldwide, paediatric tuberculosis is often undiagnosed. We aimed to investigate optimal testing strategies for microbiological confirmation of tuberculosis in children younger than 15 years, including the yield in high-risk subgroups (eg, children younger than 5 years, with HIV, or with ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Journal of pharmaceutical and biomedical analysis says. | What does the article say about Validation and application of an online extraction and liquid chromatography tandem mass spectrometry assay for the analysis of delamanid and its DM-6705 metabolite in human breast milk.? | We developed and validated a bioanalytical assay to quantify delamanid and its key metabolite (DM-6705) in breast milk and aimed to quantify the secretion of these compounds in breast milk. Due to the hydrophobic nature of the analytes, special care was taken during sample preparation to prevent the formation of fatty ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what ACS infectious diseases says. | What does the article say about Identification of Chemical Scaffolds That Inhibit the <i>Mycobacterium tuberculosis</i> Respiratory Complex Succinate Dehydrogenase.? | Drug-resistant Mycobacterium tuberculosis is a significant cause of infectious disease morbidity and mortality for which new antimicrobials are urgently needed. Inhibitors of mycobacterial respiratory energy metabolism have emerged as promising next-generation antimicrobials, but a number of targets remain unexplored. ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what The Lancet. Respiratory medicine says. | What does the article say about Long-term efficacy and safety of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): extended follow-up of an open-label, multicentre, randomised, non-inferiority trial.? | STREAM stage 2 showed that two bedaquiline-containing regimens (a 9-month all-oral regimen and a 6-month regimen with 8 weeks of aminoglycoside) had superior efficacy to a 9-month injectable-containing regimen for rifampicin-resistant tuberculosis up to 76 weeks after randomisation. Our objective in this follow-up anal... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what International journal of environmental research and public health says. | What does the article say about Perspectives of Hospital Staff on Barriers to Smoking Cessation Interventions among Drug-Resistant Tuberculosis Patients in a South African Management Hospital.? | Drug-resistant tuberculosis (DR-TB) remains a major cause of illness and death, with personal and non-addiction-related barriers. This study aimed to explore the perspectives of hospital staff on barriers to smoking cessation interventions (SCIs) for in-patients at a DR-TB management hospital in Durban, KwaZulu-Natal, ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Clinical infectious diseases : an official publication of the Infectious Diseases Society of America says. | What does the article say about Diagnostic Accuracy of Chest X-ray Computer-Aided Detection Software for Detection of Prevalent and Incident Tuberculosis in Household Contacts.? | World Health Organization (WHO) tuberculosis (TB) screening guidelines recommend computer-aided detection (CAD) software for chest radiograph (CXR) interpretation. However, studies evaluating their diagnostic and prognostic accuracy are limited. We conducted a prospective cohort study of household contacts of rifampici... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Disease models & mechanisms says. | What does the article say about Patient advocacy in tuberculosis research and treatment: an interview with Zolelwa Sifumba.? | ||
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Npj imaging says. | What does the article say about PET imaging of mycobacterial infection: transforming the pipeline for tuberculosis drug development.? | Improved PET/CT radiopharmaceuticals can better visualize and monitor tuberculosis and enable real-time pharmacological drug profiling in vivo. PET/CT imaging can therefore be used to study in animal models the changes in tissue pathology in tuberculosis infection, such as mycobacterial latency, tuberculoma formation, ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what PLOS global public health says. | What does the article say about Provider perspectives on empirical antibiotic treatment for tuberculosis-like symptoms in South Africa's private general practice sector: A qualitative study in two cities.? | While tuberculosis (TB) in South Africa is commonly treated in the public sector, some clients first seek care in the private sector. Research has demonstrated that private general practitioners (GPs) perform less well than do public sector care providers in TB testing and drug-dispensing practices. We aimed to describ... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what SA journal of radiology says. | What does the article say about A rare case of intercostal-to-pulmonary artery fistula and its endovascular treatment in the setting of post pulmonary tuberculosis bronchiectasis and haemoptysis.? | Intercostal artery-to-pulmonary artery fistula is an extremely rare variant of systemic artery-to-pulmonary artery fistulas (SA-PAFs). A case of a 38-year-old man presenting with clinically significant haemoptysis secondary to an intercostal artery-to-pulmonary artery fistula in the setting of post-pulmonary tuberculos... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what medRxiv : the preprint server for health sciences says. | What does the article say about Prevalence and predictors of tuberculosis in adults and adolescents with sputum trace Ultra results in two high-burden clinical settings.? | Some patients who test trace-positive on Xpert MTB/RIF Ultra ("Ultra"), a highly sensitive molecular diagnostic platform, may not have tuberculosis (TB) disease. A better understanding of the prevalence of TB disease, associated clinical characteristics, and utility of additional diagnostic tests among people with trac... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what BMC global and public health says. | What does the article say about Stigma relating to tuberculosis infection prevention and control implementation in rural health facilities in South Africa - a qualitative study outlining opportunities for mitigation.? | Tuberculosis (TB) is a stigmatised disease with intersectional associations with poverty, HIV, transmission risk and mortality. The use of visible TB infection prevention and control (IPC) measures, such as masks or isolation, can contribute to stigma. To explore stigma in this condition, we conducted in-depth individu... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Nature says. | What does the article say about Targeting de novo purine biosynthesis for tuberculosis treatment.? | Tuberculosis remains the leading cause of death from an infectious disease 1,2 . Here we report the discovery of a first-in-class small-molecule inhibitor targeting PurF, the first enzyme in the mycobacterial de novo purine biosynthesis pathway. The lead candidate, JNJ-6640, exhibited nanomolar bactericidal activity in... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what Journal of biomolecular structure & dynamics says. | What does the article say about Design, synthesis, computational molecular docking studies of novel heterocyclics bearing 1,2,4-triazole, 1,3,4-oxadiazole conjugates as potent antibacterial and antitubercular agents.? | Herein, we report the synthesis, and characterization of a new series of 1,3,4-oxadiazole and 1,2,4-triazole derivatives based on azaindole acetamides and assigned as potential antibacterial and antitubercular substances. The structures of these compounds were established by 1 H NMR, 13 C NMR, and HRMS spectral analysi... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what International journal of environmental research and public health says. | What does the article say about The Association Between HIV/AIDS, Ototoxicity of Its Treatments, and Occupational Noise Induced Hearing Loss: A Narrative Review Mapping the Existing Literature and Identifying Research Gaps.? | Hearing loss remains a significant but underexplored health challenge in individuals with HIV/AIDS, particularly those exposed to occupational noise. The ototoxic effects of antiretroviral therapy (ART) and comorbid conditions like tuberculosis (TB) further compound the risk. This narrative review examines the intersec... | |
You are a medical assistant tasked with answering tuberculosis-related queries. Answer based on what PLOS global public health says. | What does the article say about Assessment of comorbidities, risk factors, and post tuberculosis lung disease in National Tuberculosis Guidelines: A scoping review.? | Tuberculosis (TB) remains a major public health issue across the world and national TB guidelines are an important resource for diagnosis and treatment. This scoping review aimed to analyze how countries with the highest TB burdens approach the integration of comorbidity and risk factor screening, diagnosis and treatme... |
End of preview. Expand in Data Studio
README.md exists but content is empty.
- Downloads last month
- 6