Dataset Viewer
The dataset viewer is not available for this subset.
Cannot get the split names for the config 'default' of the dataset.
Exception:    SplitsNotFoundError
Message:      The split names could not be parsed from the dataset config.
Traceback:    Traceback (most recent call last):
                File "/usr/local/lib/python3.14/site-packages/datasets/packaged_modules/json/json.py", line 290, in _generate_tables
                  pa_table = paj.read_json(
                      io.BytesIO(batch), read_options=paj.ReadOptions(block_size=block_size)
                  )
                File "pyarrow/_json.pyx", line 342, in pyarrow._json.read_json
                File "pyarrow/error.pxi", line 155, in pyarrow.lib.pyarrow_internal_check_status
                File "pyarrow/error.pxi", line 92, in pyarrow.lib.check_status
                  raise convert_status(status)
              pyarrow.lib.ArrowInvalid: JSON parse error: Column() changed from object to number in row 0
              
              During handling of the above exception, another exception occurred:
              
              Traceback (most recent call last):
                File "/usr/local/lib/python3.14/site-packages/datasets/inspect.py", line 286, in get_dataset_config_info
                  for split_generator in builder._split_generators(
                                         ~~~~~~~~~~~~~~~~~~~~~~~~~^
                      StreamingDownloadManager(base_path=builder.base_path, download_config=download_config)
                      ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
                  )
                  ^
                File "/usr/local/lib/python3.14/site-packages/datasets/packaged_modules/json/json.py", line 101, in _split_generators
                  pa_table = next(iter(self._generate_tables(**splits[0].gen_kwargs, allow_full_read=False)))[1]
                             ~~~~^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
                File "/usr/local/lib/python3.14/site-packages/datasets/packaged_modules/json/json.py", line 304, in _generate_tables
                  batch = json_encode_fields_in_json_lines(original_batch, json_field_paths)
                File "/usr/local/lib/python3.14/site-packages/datasets/utils/json.py", line 111, in json_encode_fields_in_json_lines
                  examples = [ujson_loads(line) for line in original_batch.splitlines()]
                              ~~~~~~~~~~~^^^^^^
                File "/usr/local/lib/python3.14/site-packages/datasets/utils/json.py", line 20, in ujson_loads
                  return pd.io.json.ujson_loads(*args, **kwargs)
                         ~~~~~~~~~~~~~~~~~~~~~~^^^^^^^^^^^^^^^^^
              ValueError: Expected object or value
              
              The above exception was the direct cause of the following exception:
              
              Traceback (most recent call last):
                File "/src/services/worker/src/worker/job_runners/config/split_names.py", line 71, in compute_split_names_from_streaming_response
                  for split in get_dataset_split_names(
                               ~~~~~~~~~~~~~~~~~~~~~~~^
                      path=dataset,
                      ^^^^^^^^^^^^^
                      config_name=config,
                      ^^^^^^^^^^^^^^^^^^^
                      token=hf_token,
                      ^^^^^^^^^^^^^^^
                  )
                  ^
                File "/usr/local/lib/python3.14/site-packages/datasets/inspect.py", line 340, in get_dataset_split_names
                  info = get_dataset_config_info(
                      path,
                  ...<6 lines>...
                      **config_kwargs,
                  )
                File "/usr/local/lib/python3.14/site-packages/datasets/inspect.py", line 291, in get_dataset_config_info
                  raise SplitsNotFoundError("The split names could not be parsed from the dataset config.") from err
              datasets.inspect.SplitsNotFoundError: The split names could not be parsed from the dataset config.

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MitoSeqGen Dataset — Curated Vertebrate Mitochondrial Coding Sequences

This is the quality-controlled, deduplicated dataset used to train and evaluate MitoSeqGen, a constrained generative transformer for mammalian mitochondrial mRNA codon optimization. Training code: https://github.com/Maheshbonthada/MItoDNA

Source and construction

Coding sequences (CDS) for the 13 mitochondrial protein-coding genes (ND1, ND2, COX1, COX2, ATP8, ATP6, COX3, ND3, ND4L, ND4, ND5, ND6, CYTB) were bulk-downloaded from NCBI via the Entrez E-utilities across vertebrate mitochondrial genome records (244,874 candidate records). Each record passed an 8-layer QC pipeline (format integrity, nucleotide composition, CDS structural validity, genetic-code compliance under NCBI translation table 2, biological plausibility, exact-duplicate detection, taxonomic metadata completeness, dataset-level adequacy) — 100,250 records (40.9%) passed. Passing records were further deduplicated at the near-duplicate level (95% nucleotide identity, CD-HIT-style clustering), yielding 46,264 unique sequences spanning 4,134 species. Full methodology is in the training repo's manuscript.

This is not raw NCBI data redistribution — the raw genome files (GenBank format, ~700MB) are not included here since they are trivially re-obtainable directly from NCBI Entrez by anyone; this release is the curated, QC'd, deduplicated output specific to this project.

Files

File Description Records
mito_cds_deduped.fasta The curated dataset — final deduplicated CDS set used for train/val/test splitting 46,264
mito_cds_passed.fasta All QC-passed records before near-duplicate clustering (shows provenance) 100,250
mito_trna_passed.fasta QC-passed mitochondrial tRNA sequences (auxiliary; not used in the primary codon-optimization results)
mito_cds_stats.json Summary statistics for the deduplicated set
train.json, val.json, test.json Species-level (phylogenetic) train/val/test split indices — zero species overlap between splits 36,471 / 4,638 / 5,155
train_augmented.json Training split with 2 additional RSCU-guided synonymous variants per sequence (the actual training data fed to the model) 109,413
qc_report_2026-07-22.json Full QC audit trail: per-check pass/fail counts, rejection-reason breakdown, taxonomic/gene-length distributions

Not included (regenerable from the training repo, or available upstream): raw NCBI GenBank downloads (re-obtainable from NCBI Entrez directly), and the tokenized/model-input-format JSON files (mito_cds_tokenized*.json, regenerable from mito_cds_deduped.fasta via src/data/preprocess.py in the training repo — these are a training-format serialization of the same sequences listed above, not distinct content).

Splitting methodology

Splits are by species identity, not by individual sequence, to prevent species-level data leakage (the same species' sequence appearing in both training and evaluation). This guarantees zero species overlap between train/val/test.

License

MIT — same as the training code and model weights.

Citation

Preprint in preparation (bioRxiv); citation details will be added here once posted. In the meantime, please cite via the GitHub repository: https://github.com/Maheshbonthada/MItoDNA

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