Company: TEM
Filing Date: 2025-02-24
Form Type: S-8
Source: 0001193125-25-033507
Chunk: 1

Company: Tempus AI, Inc.
Filing Date: 2025-02-24
Form: S-8
Chunk 1
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-8,Tempus AI, Inc. (the “Registrant”) is filing this Registration Statement with the Securities and Exchange Commission (the “Commission”) to register 2,871,134 additional shares of its Class A common stock, $0.0001 par value per share (“Class A Common Stock”), under the Registrant’s 2024 Equity Incentive Plan (the “2024 Plan”), pursuant to the provisions of the 2024 Plan providing for an automatic increase in the number of shares of Class A Common Stock reserved and available for issuance under the 2024 Plan on January 1, 2025. In accordance with the instructional note to Part I of Form S-8as promulgated by the Commission, the information specified by Part I of the Form S-8has been omitted from this Registration Statement. The Registrant previously registered shares of its Class A Common Stock for issuance under the 2024 Plan on a Registration Statement on Form S-8filed with the Commission on June 17, 2024 ( File No. 333-280270) (the “Prior Registration Statement”). Pursuant to General Instruction E to Form S-8,this Registration Statement hereby incorporates by reference the contents of the Prior Registration Statement except as set forth below. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

| Item 3. | Incorporation of Documents by Reference. |

The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed by the Registrant with the Commission: (a) The Registrant’s Annual Report on Form 10-K(the “2024 10-K”)for the fiscal year ended December 31, 2024, filed with the Commission on February 24, 2025; (b) The Registrant’s Current Report on Form 8-Kfiled with the Commission on February 3, 2025 (File No. 001-42130);and (c) The description of the Registrant’s Class A Common Stock contained in the Registrant’s Registration Statement on Form 8-Afiled on June 11, 2024 (File No. 001-42130)under Section 12(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), including any amendment or report filed for the purpose of updating such description, including Exhibit 4.2of the 2024 10-K. All documents filed by the Registrant pursuant to Section 13(a), 13