Company: CERO
Filing Date: 2025-11-20
Form Type: 424B3
Source: 0001213900-25-113118
Chunk: 0

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-11-20
Form: 424B3
Chunk 0
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Filed Pursuant to Rule 424(b)(3)

Registration No. 333-283492

Prospectus Supplement No. 12

(To Prospectus dated May 23, 2025, as supplemented by

Prospectus Supplement No. 1 dated June 6, 2025

Prospectus Supplement No. 2 dated June 16, 2025

Prospectus Supplement No. 3 dated June 25, 2025

Prospectus Supplement No. 4 dated July 2, 2025

Prospectus Supplement No. 5 dated July 14, 2025

Prospectus Supplement No. 6 dated July 25, 2025

Prospectus Supplement No. 7 dated August 22, 2025

Prospectus Supplement No. 8 dated September 4, 2025

Prospectus Supplement No. 9 dated September 5, 2025

Prospectus Supplement No. 10 dated October 23, 2025

Prospectus Supplement No. 11 dated October 30, 2025)

<div align='center'>CERO THERAPEUTICS HOLDINGS, INC.

2,100,000 Shares of Common Stock</div>

This prospectus supplement no. 12 (this “Prospectus
Supplement”) amends and supplements the prospectus dated May 23, 2025 (as may be supplemented or amended from time to time, the
“Prospectus”), which forms part of our Registration Statement on Form S-1 (Registration Statement No. 333-283492), as amended
by Post-Effective Amendment No. 1 thereto. This Prospectus Supplement is being filed to update and supplement the information included
or incorporated by reference in the Prospectus with the information contained in the attached Quarterly Report on Form 10-Q, filed with
the Securities and Exchange Commission (the “Securities and Exchange Commission”) on November 19, 2025 (the “Form 10-Q”).
Accordingly, we have attached the Form 10-Q to this Prospectus Supplement.

This Prospectus Supplement updates and supplements
the information in the Prospectus and is not complete without, and may not be delivered or utilized except in combination with, the Prospectus,
including any amendments or supplements thereto. This Prospectus Supplement should be read in conjunction with the Prospectus, and if
there is any inconsistency between the information in the Prospect