Company: HURA
Filing Date: 2025-12-10
Form Type: 424B5
Source: 0001193125-25-313799
Chunk: 42

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-12-10
Form: 424B5
Chunk 42
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 terminated:

| • |     | by written notice to the trustee and us from the person or persons who gave such payment blockage notice; |

| • |     | because the default giving rise to such payment blockage notice is cured, waived or otherwise no longer 
 continuing; or                                                                                          |

| • |     | because such senior debt has been discharged or repaid in full in cash. |

Notwithstanding the foregoing, if the holders of senior indebtedness or their representatives have not accelerated the maturity of the senior indebtedness at the end of the 179-dayperiod, we may resume payments on the subordinated debt securities. Not more than one payment blockage notice may be given in any consecutive 360-dayperiod, irrespective of the number of defaults with respect to senior indebtedness during that period. No default existing on the beginning date of any payment blockage period initiated by a person or persons may be the basis of a subsequent payment blockage period with respect to the senior indebtedness held by that person unless that default has been cured or waived for a period of not fewer than 90 consecutive days. If we pay or distribute our assets to creditors upon a total or partial liquidation, dissolution or reorganization of or similar proceeding relating to us or our property, then:

| • |     | the holders of senior indebtedness will be entitled to receive payment in full in cash of the senior indebtedness 
 before the holders of subordinated debt securities are entitled to receive any payment; and                       |

| • |     | until the senior indebtedness is paid in full in cash, any payment or distribution to which holders of                                                                                                                                                
 subordinated debt securities would be entitled but for the subordination provisions of the subordinated indenture will be made to holders of the senior indebtedness, except that holders of subordinated debt securities may receive certain capital 
 stock and subordinated debt.                                                                                                                                                                                                                          |

If a distribution is made to holders of subordinated debt securities that, due to the subordination provisions, should not have been made to them, those holders of subordinated debt securities are required to hold it in trust for the holders of senior indebtedness, and pay it over to them as their interests may appear. After all senior indebtedness is paid in full and until the subordinated debt securities are paid in full, holders of subordinated debt securities will be subrogated to the rights of holders of senior indebtedness to receive distributions applicable to such senior indebtedness. As a result of the subordination provisions contained in the subordinated indenture,