Company: SHPH
Filing Date: 2025-08-08
Form Type: CORRESP
Source: 0001641172-25-022787
Chunk: 0

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-08-08
Form: CORRESP
Chunk 0
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<div align='center'>SHUTTLE PHARMACEUTICALS HOLDINGS, INC.

401 Professional Drive, Suite 260

Gaithersburg, MD 20879</div>

August 8, 2025

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Trade & Services

100 F Street, N.E.

Washington, D.C. 20549

| Attention: | Mr.         
 Tyler Howes |

| Re: | Shuttle                        
 Pharmaceuticals Holdings, Inc. 
 Registration                   
 Statement on Form S-1          
 Filed                          
 August 5, 2025                 |
|:----|:-------------------------------|
|     | File                           
 No. 333-289231                 |

Dear Mr. Howes,

Pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), Shuttle Pharmaceuticals Holdings, Inc. (the “Company”) respectfully requests that the Securities and Exchange Commission accelerate the effectiveness of the above-referenced Registration Statement on Form S-1 (the “Registration Statement”) and declare such Registration Statement effective at 4:30 p.m., Eastern Standard Time, on Monday, August 11, 2025, or as soon thereafter as practicable.

It would be appreciated if, as soon as the Registration Statement is declared effective, you would so inform Jeff Cahlon, Esq. of Sichenzia Ross Ference Carmel at 212-930-9700.

<div align='center'>* * * *</div>

Very Truly Yours,

| Shuttle                        
 Pharmaceuticals Holdings, Inc. |
| /s/                            
 Christopher Cooper             |
| Christopher                    
 Cooper                         |
| Chief                          
 Executive Officer              |

cc: Jeff Cahlon, Esq.