Company: SCLXW
Filing Date: 2025-07-23
Form Type: 424B3
Source: 0001193125-25-163077
Chunk: 86

Company: Scilex Holding Co
Filing Date: 2025-07-23
Form: 424B3
Chunk 86
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 necessary to correct this definition or any portion of this definition which may be defective or
inconsistent with the intended treatment of such instrument or transaction.

“GAAP” shall have the
meaning assigned to such term in .

“Hazardous Materials” shall
have the meaning assigned to such term in .

“Indebtedness” shall
have the meaning assigned to such term in .

“Initial Registration Statement” shall have the meaning assigned to such term in the Registration Rights Agreement.

“Intellectual Property Rights” shall have the meaning assigned to such term in
.

“Investment Period” means the period commencing on the
Effective Date of the Initial Registration Statement and expiring on the date this Agreement is terminated pursuant to .

“Investor” shall have the meaning assigned to such term in the introductory paragraph of this Agreement.

“Investor Expense Reimbursement” shall have the meaning assigned to such term in
hereof.

“Investor Party” shall have the meaning assigned
to such term in .

“Issuer Covered Person” shall have the meaning
assigned to such term in .

“IT Systems” shall have the meaning
assigned to such term in .

“Knowledge” means the actual knowledge
of either of (a) the Company’s Chief Executive Officer, and (b) the Company’s Chief Financial Officer, in each case after reasonable inquiry of all officers, directors and employees of the Company and its Subsidiaries under such
Person’s direct supervision who would reasonably be expected to have knowledge or information with respect to the matter in question.

“Material Adverse Effect” means (a) any condition, occurrence, state of facts or event having, or
insofar as reasonably can be foreseen would likely have, any material adverse effect on the legality, validity or enforceability of the Transaction Documents or the transactions contemplated thereby, (b) any condition, occurrence, state of
facts or event having, or insofar as reasonably can be foreseen would likely have, any effect on the business, operations, properties, or financial condition of the Company that is material and adverse to the Company and its Subsidiaries, taken as a
whole, and/or (c) any condition, occurrence, state of facts or event that would, or insofar as reasonably can be foreseen would likely, prohibit or otherwise

I-5

materially interfere with or delay the ability of the Company to perform any of its obligations under the Transaction Documents; , , that no facts, circumstances,
changes or effects exclusively and