Company: DMAC
Filing Date: 2025-11-13
Form Type: S-8
Source: 0001437749-25-034866
Chunk: 2

Company: DiaMedica Therapeutics Inc.
Filing Date: 2025-11-13
Form: S-8
Chunk 2
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 2025)                    
 Amended and Restated Articles of DiaMedica Therapeutics Inc. dated May 17, 2023 (incorporated by reference to Exhibit 3.1 to current report on Form 8-K filed May 18, 2023)                             |
|:--------|:----|:--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 5.1+    |     | Opinion of  Pushor Mitchell LLP                                                                                                                                                                         |
| 23.1+   |     | Consent of Baker Tilly US, LLP, independent registered public accounting firm for the Registrant                                                                                                        |
| 23.2+   |     | Consent of  Pushor Mitchell LLP (included in Exhibit 5.1)                                                                                                                                               |
| 24+     |     | Powers of Attorney (included with signatures)                                                                                                                                                           |
| 99.1    |     | Amended and Restated 2021 Employment Inducement Incentive Plan dated July 31, 2025 (incorporated by reference to Exhibit 10.3 to quarterly report on Form 10-Q for the period ended September 30, 2025) |
| 107+    |     | Filing Fee Table                                                                                                                                                                                        |

+ Filed herewith

<div align='center'>SIGNATURES</div>

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S‑8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of Minneapolis, State of Minnesota , on November 13, 2025.

| DIAMEDICA THERAPEUTICS INC. |     |                                              |
| By:                         |     | /s/ Rick Pauls                               |
|                             |     | Name: Rick Pauls                             |
|                             |     | Title: President and Chief Executive Officer |

<div align='center'>POWERS OF ATTORNEY</div>

Each person whose signature appears below hereby constitutes and appoints Rick Pauls and Scott Kellen, and each of them acting individually, as his or her true and lawful attorneys-in-fact and agents, with full power of each to act alone, with full powers of substitution and resubstitution, for him and in his name, place and stead, in any and all capacities, to sign the Registration Statement filed herewith and any and all amendments to said