Company: NCNA
Filing Date: 2025-05-01
Form Type: CORRESP
Source: 0001193125-25-110312
Chunk: 0

Company: NuCana plc
Filing Date: 2025-05-01
Form: CORRESP
Chunk 0
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May 1, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549

| Re: | NuCana plc |

Registration Statement on Form F-1,as amended File No. 333-286737 Withdrawal of Request for Acceleration of Effective Date Ladies and Gentlemen: Reference is made to our letter, filed as correspondence via EDGAR on April 29, 2025, in which we requested the acceleration of the effective date of the above-referenced Registration Statement for Wednesday, April 30, 2025 at 5:00 p.m. Eastern Time, in accordance with Rule 461 under the Securities Act of 1933, as amended. We are no longer requesting that such Registration Statement be declared effective at this time and we hereby formally withdraw our request for acceleration of the effective date. [Signature Page to Follow]

| Very truly yours,           |     |                         |
| LAIDLAW & COMPANY (UK) LTD. |     |                         |
| By:                         |     | /s/ Luke Kottke         |
| Name:                       |     | Luke Kottke             |
| Title:                      |     | Head of Capital Markets |

[Signature Page to Placement Agent’s Withdrawal of Acceleration Request]