Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 3

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 3
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 may amend or supplement this prospectus from time to time by filing amendments or supplements as
required. You should read this prospectus, together with additional information described under the heading “Where You Can Find More Information”, and any amendments or supplements carefully before you invest in any of our
securities.

INVESTING IN OUR COMMON STOCK INVOLVES SUBSTANTIAL RISKS. YOU SHOULD REVIEW CAREFULLY THE RISKS AND UNCERTAINTIES DESCRIBED UNDER THE HEADING “RISK FACTORS” BEGINNING ON PAGE 21 OF THIS PROSPECTUS.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed
upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.

The date of this prospectus is December 29, 2025

TABLE OF CONTENTS

|                                                                         |     | Page |     |
| ABOUT THIS PROSPECTUS                                                   |     |      |   1 |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS                    |     |      |   2 |
| CERTAIN DEFINED TERMS                                                   |     |      |   4 |
| PROSPECTUS SUMMARY                                                      |     |      |   9 |
| THE OFFERING                                                            |     |      |  17 |
| RISK FACTORS                                                            |     |      |  21 |
| MARKET AND INDUSTRY DATA                                                |     |      | 112 |
| USE OF PROCEEDS                                                         |     |      | 113 |
| DETERMINATION OF OFFERING PRICE                                         |     |      | 114 |
| DILUTION                                                                |     |      | 115 |
| SELLING STOCKHOLDERS                                                    |     |      | 116 |
| PLAN OF DISTRIBUTION                                                    |     |      | 119 |
| DESCRIPTION OF THE EXCHANGE WARRANTS                                    |     |      | 123 |
| DESCRIPTION OF THE SEPTEMBER 2025 WARRANTS                              |     |      | 125 |
| DESCRIPTION OF THE NOVEMBER 2025 WARRANTS                               |     |      | 127 |
| MARKET INFORMATION FOR SECURITIES AND DIVIDEND POLICY                   |     |      | 129 |
| MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS 
 OF OPERATIONS                                                           |     |      | 130 |
| BUSINESS                                                                |     |      | 165 |
|