Company: AZN
Filing Date: 2025-09-29
Form Type: 6-K
Source: 0001104659-25-094039
Chunk: 1

Company: ASTRAZENECA PLC
Filing Date: 2025-09-29
Form: 6-K
Chunk 1
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<div align='center'>**(incorporated in England and Wales with registered number 02723534)

Proposed implementation of Harmonised Listing Structure involving 
 a direct listing of AstraZeneca Shares on the NYSE**</div>

#### and

#### Notice of General Meeting
You should read the whole of this document. Your attention is drawn to the letter from the Chair of AstraZeneca which is set out in Part I ( Letter from the Chair of AstraZeneca PLC ) and Part II ( Explanation of the proposals to implement the Harmonised Listing Structure ) and which contains the unanimous recommendation of the directors of AstraZeneca that you vote in favour of the Resolution.

Notice of the General Meeting, which will be digitally-enabled and will be held on 3 November 2025 at 2:30 p.m. (GMT), is included at Part VII ( Notice of General Meeting ) of this document. This document should be read in conjunction with the relevant documents listed below concerning your shareholding in the Company:

(A)

for Shareholders who receive hard copy communications, the Form of Proxy (or, in the case of those who hold their shares through the CSN Facility, the CSN voting form);

(B)

for Shareholders who receive shareholder communications electronically, the combined voting instruction card and notice of availability (or, in the case of those who hold their shares in the CSN Facility, the combined CSN voting instruction card and notice of availability); or

(C)

for holders of Swedish Listed Shares and AstraZeneca ADSs, the separate documentation made available to such persons, respectively.

Further details of the action to be taken by Shareholders in relation to the appointment of proxies is set out in the section of this document entitled “Action to be taken” set out on pages 5 to 6 of this document.

Capitalised terms used in this document have the meanings ascribed to them in Part VI ( Definitions ) of this document.

This document is dated 29 September 2025.

TABLE OF CONTENTS

CONTENTS

| CLAUSE                                                                                          | ​ | ​ | PAGE |   |    |   | ​ |
| EXPECTED TIMETABLE OF PRINCIPAL EVENTS                                                          | ​ | ​ | ​    | ​ |  2 | ​ | ​ |
| IMPORTANT NOTICES                                                                               | ​ | ​ | ​    | ​ |  3 | ​ | ​ |
| ACTION TO BE TAKEN                                                                              | ​ | ​ | ​    | ​ |  5