Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 64

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 64
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 of the assets used by such purchaser or subsequent transferee to
acquire or hold a depositary share constitutes assets of any Plan or (ii) (A) the purchase and holding of a depositary share by such purchaser or transferee will not constitute a non-exempt prohibited
transaction under Section 406 of ERISA or Section 4975 of the Code or similar violation under any applicable Similar Laws and (B) neither we nor any of our affiliates is a “fiduciary” within the meaning of Section 3(21)
of ERISA or, with respect to a Plan not subject to ERISA, under any applicable Similar Law, with respect to the purchaser or holder in connection with such person’s acquisition, holding or disposition of the depository shares, or as a result of
the exercise by us or any of our affiliates of any rights in connection with the depository shares.

The foregoing discussion is general
in nature, is not intended to be all-inclusive, and is based on laws as in effect on the date of this prospectus supplement. Such discussion should not be construed as legal advice. Due to the complexity of
these rules and the penalties that may be imposed upon persons involved in non-exempt prohibited transactions, it is particularly important that fiduciaries, or other persons considering purchasing or holding
the depositary shares on behalf of, or with the assets of, any Plan, consult with their counsel regarding the potential applicability of ERISA, Section 4975 of the Code and any Similar Laws to such investment and whether an exemption would be
applicable to the purchase and holding of the depositary shares.

Purchasers and holders of the depositary shares have the exclusive
responsibility for ensuring that their purchase and holding of the depositary shares complies with the fiduciary responsibility rules of ERISA, if applicable, and does not violate the prohibited transaction rules of ERISA, the Code or applicable
Similar Laws. Neither we nor any underwriters, or our or their respective affiliates, agents or representatives, make any representation as to whether an investment in the depositary shares is appropriate for Plans in general or for any particular
Plan or arrangement.

S-44

UNDERWRITING (CONFLICTS OF INTEREST) Under the terms and subject to the conditions contained in an underwriting agreement, dated August 4, 2025 (the “underwriting agreement”), the underwriters named below (the “underwriters”), for whom Morgan Stanley & Co. LLC, BofA Securities