Company: CRVO
Filing Date: 2025-11-07
Form Type: S-8
Source: 0001437749-25-033900
Chunk: 1

Company: CervoMed Inc.
Filing Date: 2025-11-07
Form: S-8
Chunk 1
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EXPLANATORY NOTE</div>

This Registration Statement has been filed by CervoMed Inc. (the “Registrant,” “CervoMed,” “we,” “us” or “our”), with the United States Securities and Exchange Commission (the “Commission”) to register 800,000 shares of common stock, par value $0.001 per share (“common stock”) to be offered under the Registrant’s 2025 Equity Incentive Plan (the “2025 Plan”), all of which were reserved for issuance under the 2025 Plan on June 23, 2025 pursuant to Section 4.1(a) and certain other provisions related thereto.

In addition, this Registration Statement is filed to register an aggregate of 129,000 shares of the Registrant’s common stock that may be issued upon exercise of previously announced non-qualified stock option inducement awards (the “Inducement Awards”), granted to two employees on June 9, 2025 and October 6, 2025, each in accordance with Nasdaq Listing Rule 5635(c)(4) as an inducement material to each such person entering into employment with the Registrant.

<div align='center'>PART I

INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>

In accordance with the instructional Note to Part I of Form S-8 as promulgated by the Commission, the information specified by Part I of Form S-8 has been omitted from this Registration Statement on Form S-8 for offers of the Registrant’s common stock pursuant to the 2025 Plan and the Inducement Awards. The documents containing the information specified in Part I will be delivered to the participants in the 2025 Plan and the Inducement Awards covered by this Registration Statement as required by Rule 428(b)(1) under the Securities Act of 1933, as amended (the “Securities Act”).

<div align='center'>PART II

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>

In this registration statement, CervoMed Inc. is sometimes referred to as“Registrant,” “we,” “us” or“our.”

Item 3. Incorporation of Documents by Reference.

The following documents filed by the Registrant with the Commission are incorporated herein by reference:

All reports and other documents filed by the Registrant after the date hereof pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act of