Company: IMRX
Filing Date: 2025-05-05
Form Type: S-8
Source: 0001104659-25-044519
Chunk: 1

Company: Immuneering Corp
Filing Date: 2025-05-05
Form: S-8
Chunk 1
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) of Securities Act. ¨

<div align='center'>EXPLANATORY NOTE</div>

This Registration Statement on Form S-8 is
being filed for the purpose of registering an aggregate of 6,500,000 shares of Immuneering Corporation’s (the “Registrant”)
Class A common stock, $0.001 par value per share (“Class A common stock”), which may be issued pursuant to the Immuneering
Corporation 2021 Incentive Award Plan (the “2021 Plan”), the Immuneering Corporation 2021 Employee Stock Purchase Plan (the
“2021 ESPP”), and the Immuneering Corporation 2025 Employment Inducement Award Plan (the “2025 Inducement Plan”
and, together with the 2021 Plan and the 2021 ESPP, the “Plans”).

The additional shares registered pursuant to the Plans are of the same class as other securities relating to the 2021 Plan and the 2021 ESPP for which the Registration Statement on Form S-8 (File No. 333-258416)
is effective and incorporated by reference herein.

| Item 8. | Exhibits |

| Exhibit 
 Number  |                 |     | Description                                                                                                             |
| 4.1     |                 |     | Amended and Restated Certificate of Incorporation of                                                                    
 Immuneering Corporation (incorporated by reference to Exhibit 3.1 to the Registrant’s Quarterly Report on Form 10-Q     
 (File No. 001-40675) filed on September 9, 2021).                                                                       |
| 4.2     |                 |     | Amended and Restated Bylaws of Immuneering Corporation                                                                  
 (currently in effect) (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K (File    
 No. 001-40675) filed on February 2, 2024).                                                                              |
| 4.3     |                 |     | Specimen Stock Certificate evidencing the shares of                                                                     
 Class A Common Stock (incorporated by reference to Exhibit 4.1 to the Registrant’s Registration Statement on Form S-1/A 
 (File No. 333-257791) filed on July 26, 2021).                                                                          |
| 5.1*    |                 |     | Opinion                                                                                                                 
 of Latham & Watkins LLP.                                                                                                |
| 23.1