Company: EPR-PE
Filing Date: 2025-12-05
Form Type: 424B5
Source: 0001193125-25-309969
Chunk: 6

Company: EPR PROPERTIES
Filing Date: 2025-12-05
Form: 424B5
Chunk 6
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| • |     | Risks associated with the relatively illiquid nature of our real estate investments; |

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| • |     | Risks with owning assets in foreign countries; |

| • |     | Risks associated with owning, operating or financing properties for which the tenants’, mortgagors’ or our 
 operations may be impacted by weather conditions, climate change and natural disasters;                    |

| • |     | Risks associated with the development, redevelopment and expansion of properties and the acquisition of other real estate 
 related companies;                                                                                                        |

| • |     | Our ability to pay dividends in cash or at current rates; |

| • |     | Risks associated with the impact of inflation or market interest rates on the value of our shares; |

| • |     | Fluctuations in the market prices for our shares; |

| • |     | Certain limits on changes in control imposed under law and by our Declaration of Trust and Bylaws; |

| • |     | Policy changes obtained without the approval of our shareholders; |

| • |     | Equity issuances that could dilute the value of our shares; |

| • |     | Future offerings of debt or equity securities, which may rank senior to our common shares; |

| • |     | Risks associated with changes in foreign exchange rates; and |

| • |     | Changes in laws and regulations, including tax laws and regulations. |

You should consider the risks described in the “Risk Factors” section of this prospectus supplement, the “Risk Factors” section of the accompanying prospectus and the “Risk Factors” section of our most recent Annual Report on Form 10-Kand, to the extent applicable, our subsequent filings with the SEC in evaluating any forward-looking statements included or incorporated by reference in this prospectus supplement and the accompanying prospectus. Given these uncertainties, you should not place undue reliance on forward-looking statements. Except as required by law, we undertake no obligation to publicly update or revise any forward-looking statements included or incorporated by reference in this prospectus supplement or the accompanying prospectus, whether as a result of new information, future events or otherwise. In light of the factors referred to above, the future events discussed or incorporated by reference in this prospectus supplement or the accompanying prospectus may not occur and actual results, performance or achievements could differ materially from those anticipated or implied in the forward-looking statements. S-4

Summary

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