Company: TVRD
Filing Date: 2025-02-14
Form Type: 424B3
Source: 0001104659-25-014310
Chunk: 9

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-02-14
Form: 424B3
Chunk 9
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 STATEMENTS                                         | ​ | ​ | ​    | ​ | F-1 | ​ | ​ |

ANNEX:

| ​ | ANNEX A –                                                                               
 MERGER AGREEMENT                                                                        
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| ​ | ANNEX B –                                                                               
 OPINION OF PIPER SANDLER                                                                
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| ​ | ANNEX C –                                                                               
 GENERAL CORPORATION LAW OF THE STATE OF DELAWARE REGARDINGAPPRAISAL RIGHTS, SECTION 262 
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| ​ | ANNEX D –                                                                               
 2025 EQUITY INCENTIVE PLAN                                                              
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| ​ | ANNEX E –                                                                               
 2025 EMPLOYEE STOCK PURCHASE PLAN                                                       
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| ​ | ANNEX F –                                                                               
 CERTIFICATE OF AMENDMENT OF AMENDED AND RESTATED CERTIFICATE                            
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TABLE OF CONTENTS

| ​ | OF INCORPORATION OF CARA THERAPEUTICS, INC. TO PROVIDE FOR REVERSE STOCK SPLIT                                                                        | ​ |
| ​ | ANNEX G –                                                                                                                                             
 CERTIFICATE OF AMENDMENT OF AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF CARA THERAPEUTICS, INC. TO PROVIDE FOR INCREASE IN AUTHORIZED SHARES 
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| ​ | ANNEX H –                                                                                                                                             
 FORM OF PROXY CARD FOR SPECIAL MEETING OF CARA THERAPEUTICS, INC.                                                                                     
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TABLE OF CONTENTS

### QUESTIONS AND ANSWERS ABOUT THE MERGER
Except where specifically noted, the following information and all other information contained in this proxy statement/prospectus does not give effect to the proposed reverse stock split (Reverse Stock Split) of common stock of Cara, as described in Proposal No. 4 beginning on page 231of this proxy statement/ prospectus. The following section provides answers to frequently asked questions about the proposed Merger and the Cara special meeting. This section, however, provides only summary information. For a more complete response to these questions and for additional information, please refer to the cross-referenced sections.

**Q:**

#### What is the Merger?
A:

Cara, Merger Sub, and Tvardi entered into the Merger Agreement on December 17, 2024