Company: SRPT
Filing Date: 2025-03-03
Form Type: S-3ASR
Source: 0001193125-25-044088
Chunk: 38

Company: Sarepta Therapeutics, Inc.
Filing Date: 2025-03-03
Form: S-3ASR
Chunk 38
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ifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized in the City of Cambridge, Commonwealth of Massachusetts, on March 3, 2025.

| SAREPTA THERAPEUTICS, INC. |     |                                       |
| By:                        |     | /s/ Douglas S. Ingram                 |
|                            |     | Douglas S. Ingram                     |
|                            |     | President and Chief Executive Officer |

SIGNATURES AND POWERS OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Douglas Ingram, Ian M. Estepan and Cristin Rothfuss, and each of them, with full power of substitution and resubstitution and full power to act without the other, as his or her true and lawful attorney-in-factand agent to act in his or her name, place and stead and to execute in the name and on behalf of each person, individually and in each capacity stated below, and to file, any and all documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-factand agents, and each of them, full power and authority to do and perform each and every act and thing, ratifying and confirming all that said attorneys-in-factand agents or any of them or their and his or her substitute or substitutes, may lawfully do or cause to be done by virtue thereof. Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities indicated and on the dates indicated.

| Signature                      
 /s/ Douglas S. Ingram          
 Douglas S. Ingram              
 /s/ Ian M. Estepan             
 Ian M. Estepan                 |     | Title                                             
 President and Chief Executive Officer, Director   
 (Principal Executive Officer)                     
 Executive Vice President, Chief Financial Officer 
 (Principal Financial and Accounting Officer)      |     | Date          
 March 3, 2025 
 March 3, 2025 |
|:-------------------------------|:----|:--------------------------------------------------|:----|:--------------|
| /s/ M. Kathleen Behrens, Ph.D. 
 M. Kathleen Behrens, Ph.D.     |     | Chairwoman of the Board                           |     | March 3, 2025 |
| /