Company: CMA
Filing Date: 2025-11-25
Form Type: DEFM14A
Source: 0001193125-25-297173
Chunk: 399

Company: COMERICA INC
Filing Date: 2025-11-25
Form: DEFM14A
Chunk 399
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 PORTIONS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE RESTRICTIONS SET FORTH IN THE CERTIFICATE OF DESIGNATIONS. IN CONNECTION WITH ANY TRANSFER, THE HOLDER WILL DELIVER TO THE REGISTRAR NAMED ON THE FACE OF THIS CERTIFICATE SUCH CERTIFICATES AND OTHER INFORMATION AS SUCH REGISTRAR MAY REASONABLY REQUIRE TO CONFIRM THAT THE TRANSFER COMPLIES WITH THE FOREGOING RESTRICTIONS.] 1

| Number: [ ] |     | CUSIP NO.: |

6.875% Fixed-Rate Reset Non-CumulativePerpetual Preferred Stock, Series B [ ] Shares

| 1 | To be included if the certificate is in global form, otherwise to be removed. |

COMERICA INCORPORATED FACE OF SECURITY This certifies that [Cede & Co.] 2is the owner of [ ] fully paid and non-assessableshares of the 6.875% Fixed-Rate Reset Non-CumulativePerpetual Preferred Stock, Series B, without par value, of Comerica Incorporated, a Delaware corporation (hereinafter called the “ Corporation”), transferable on the books of the Corporation by the holder hereof in person or by duly authorized attorney, upon surrender of this Certificate properly endorsed. This certificate and the shares represented hereby are issued and shall be held subject to all the provisions of the Restated Certificate of Incorporation of the Corporation and all amendments thereto (copies of which are on file at the office of the Registrar) to all of which the holder of this certificate by acceptance hereof assents. This certificate is not valid until countersigned by the Registrar.

| 2 | To be included if the certificate is in global form, otherwise to be the name of the holder of the certificated 
 shares.                                                                                                         |

IN WITNESS WHEREOF, the Corporation has caused this certificate to be executed. Comerica Incorporated

| By:    |     |                                                             |
| Name:  |     | James J. Herzog                                             |
| Title: |     | Senior Executive Vice President and Chief Financial Officer |

D-10

REGISTRAR’S COUNTERSIGNATURE This is one of the certificates representing shares of the 6.875% Fixed-Rate Reset Non-CumulativePerpetual Preferred Stock, Series B, referred to in the within mentioned Certificate of Designations.

| Computershare Trust Company, N.A. |
| By:                               |