Company: SHPH
Filing Date: 2025-03-13
Form Type: 424B3
Source: 0001493152-25-010109
Chunk: 46

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-03-13
Form: 424B3
Chunk 46
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 than the fair market value of the underlying shares as determined pursuant to the Plan, restricted stock awards, other stock- based awards, or any combination of the foregoing. The Plan is administered by the Company’s compensation committee or, alternatively, if there is no compensation committee, the Company’s board of directors. We have reserved 3,000,000 shares of our common stock for issuance under the Plan, of which 1,174,683 shares have been granted under the Plan as of the date of this registration statement and 244,439 remain subject to vesting.

The following table provides information as of December 31, 2024 about our equity compensation plans and arrangements, as adjusted for the February 28, 2025 accelerated vesting of grants to resigning board members and the March 5, 2025 grants to new directors.

| Plan category                                              |     | Number of securities to be issued upon exercise of 
 outstanding options, warrants and rights           |         |     | Weighted- average exercise price of outstanding options, 
 warrants and rights                                      |      |     | Number of securities remaining available for future 
 issuance under equity compensation plans            |         |
|:-----------------------------------------------------------|:----|:---------------------------------------------------|--------:|:----|:---------------------------------------------------------|-----:|:----|:----------------------------------------------------|--------:|
| Equity compensation plans approved by security holders     |     |                                                    | 796,925 |     | $                                                        | 0.74 |     |                                                     | 679,424 |
| Equity compensation plans not approved by security holders |     |                                                    |         |     |                                                          |      |     |                                                     |         |
| Total                                                      |     |                                                    | 796,925 |     |                                                          | 0.74 |     |                                                     | 679,424 |

*Outstanding equity incentive grants consist entirely of RSUs which automatically vest over time into an equal number of shares of common stock at no additional cost to the holder.

<div align='center'>CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS</div>

Unless described below, during the last two fiscal years, there were no transactions or series of similar transactions to which we were a party or will be a party, in which:

| ● | the                                                                                                                                
 amounts involved exceed or will exceed $120,000; and                                                                               |
| ● | any                                                                                                                                
 of our directors, executive officers or holders of more than 5% of our capital stock, or any member of the immediate family of any