Company: SCLXW
Filing Date: 2025-05-07
Form Type: POS AM
Source: 0001193125-25-115095
Chunk: 412

Company: Scilex Holding Co
Filing Date: 2025-05-07
Form: POS AM
Chunk 412
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ify or reject a related person transaction, our Audit Committee, or other independent body of our Board, must consider, in light of known circumstances, whether the transaction is in, or is not inconsistent with, our best interests and those of our stockholders, as our Audit Committee, or other independent body of our Board, determines in the good faith exercise of our discretion. 255

PRINCIPAL SECURITYHOLDERS The following table sets forth information regarding the beneficial ownership of our Common Stock as of March 31, 2025 by:

| • |     | each person or “group” known to be the beneficial owner of more than 5% of our outstanding Common Stock; |

| • |     | each of our named executive officers and directors; and |

| • |     | all of our executive officers and directors as a group. |

Beneficial ownership is determined according to the rules of the SEC, which generally provide that a person has beneficial ownership of a security if he, she or it possesses sole or shared voting or investment power over that security, including options and warrants that are currently exercisable or exercisable within 60 days. Shares subject to options and warrants that are currently exercisable or exercisable within 60 days of March 31, 2025 are considered outstanding and beneficially owned by the person holding such options or warrants for the purpose of computing the percentage ownership of that person, but are not treated as outstanding for the purpose of computing the percentage ownership of any other person. The beneficial ownership of our Common Stock is based on 6,951,671 shares of such common stock outstanding as of March 31, 2025. Voting power is based on 6,951,671 shares of Common Stock and 29,057,097 shares of Series A Preferred Stock outstanding as of March 31, 2025, with the Series A Preferred Stock entitled to an aggregate of 922,447 votes as a result of adjustments to the deemed conversion price of such preferred stock in accordance with the terms of the Series A Certificate of Designations. Shares of Series A Preferred Stock are held solely by SCLX JV. Unless otherwise indicated, we believe, based on information available to us, that all persons and entities named in the table have sole voting and investment power with respect to all shares shown as beneficially owned by them.

|                                                                 |     | Common Stock |           |     |     |        |       |   |     | Series A Preferred Stock |            |     |           |        |