Company: TEM
Filing Date: 2025-03-07
Form Type: 424B3
Source: 0001193125-25-049935
Chunk: 20

Company: Tempus AI, Inc.
Filing Date: 2025-03-07
Form: 424B3
Chunk 20
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. Ghenchev resigned from our board of directors effective as of the IPO Date. |

Mr. Lefkofsky, our Chief Executive Officer, Founder and Chairman, is also a member of our board of directors but does not receive any additional compensation for his service as a director. See the section titled “Executive Compensation” for more information regarding the compensation earned by Mr. Lefkofsky. Non-EmployeeDirector Compensation Policy Our board of directors adopted a non-employeedirector compensation policy in February 2024, which became effective upon the effectiveness of our IPO and is applicable to all of our non-employeedirectors. This compensation policy provides that each such non-employeedirector is eligible to receive the following compensation for service on our board of directors:

| • |     | an annual cash retainer of $50,000 (plus an additional $12,500 for the               
 non-executive chair or lead independent director of our board of directors, if any); |

| • |     | an additional annual cash retainer of $12,500 for service as a member of the audit committee, compensation 
 committee and the nominating and corporate governance committee;                                           |

| • |     | an initial RSU grant having a grant date fair value of $500,000 on the date of each such non-employee director’s appointment to our board of directors; |

| • |     | a refresh RSU grant having a grant date fair value of $500,000 on the fifth anniversary of such non-employee director’s initial RSU grant or initial public offering grant, as described below; as applicable; and |

| • |     | an annual RSU grant having a grant date fair value of $125,000 on the date of each of our annual stockholder 
 meetings.                                                                                                    |

Under the non-employee director compensation policy, all annual cash compensation amounts will be payable in equal quarterly installments in arrears, on the last day of each fiscal quarter in which the service occurred. In addition, each non-employee director may elect on an annual basis to receive all or a portion of his or her eligible cash compensation in the form of RSUs, which will generally vest in substantially equal quarterly installments on the last day of each fiscal quarter over the number of quarters to which the election applies, subject to the director’s continuous service to us through each applicable vesting date. 14

In connection with our IPO and effective as of the IPO Date, we granted each
of our