Company: APM
Filing Date: 2025-12-05
Form Type: 424B5
Source: 0001213900-25-118752
Chunk: 384

Company: Aptorum Group Ltd
Filing Date: 2025-12-05
Form: 424B5
Chunk 384
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 proposed to be sold for at least one year, including the holding
period of any prior owner other than one of our affiliates, is entitled to sell his, her or its shares under Rule 144 without complying
with the provisions relating to the availability of current public information or with any other conditions under Rule 144. Therefore,
unless subject to a lock-up agreement or otherwise restricted, such shares may be sold immediately upon the closing of the IPO.

<div align='center'>221

SELLING SECURITYHOLDERS</div>

This prospectus relates to
the possible resale from time to time by the Selling Securityholders of any or all of the Class A Ordinary Shares. For additional information
regarding the issuance of Class A ordinary shares covered by this prospectus, see the section titled “Recent Events – Registered Direct Offering and Concurrent Private Placement” above.

We are registering the shares
of common stock pursuant to the provisions of the Purchase Agreement entered into in October 2025.

The following table sets forth:

| ● | the name of the Selling Securityholder; |

| ● | the number of Class A ordinary shares that the Selling Securityholders beneficially owned prior to the Offering for resale of the shares under this prospectus; |

| ● | the maximum number of our Class A ordinary shares that may be offered for resale for the account of the Selling Securityholders under this prospectus; and |

| ● | the number and percentage of our Class A ordinary shares beneficially                                                                   
 owned by the after the Offering of the shares (assuming all of the offered shares are sold by the Selling Securityholders), is based on 
 6,346,823 Class A Ordinary Shares and 1,796,934 Class B Ordinary Shares.                                                                |

None of the Selling Securityholders
is a broker dealer or an affiliate of a broker dealer. None of the Selling Securityholders has any agreement or understanding to distribute
any of the shares being registered.

Each Selling Securityholder
may offer for sale all or part of the shares from time to time. The table below assumes that the Selling Securityholders will sell all
of the shares offered for resale. A Selling Securityholder is under no obligation, however, to sell any shares pursuant to this prospectus.

| Name of Selling Securityholder        |     |        Class A 
       Ordinary 
         Shares 
   Beneficially 
    Owned Prior 
 to Offering(1) |     |   Maximum 
 Number of 
   Class A 
  Ordinary 
 Shares to 
   be Sold |     |   Number