Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 55

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 55
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 ADSs. The withdrawal of the ordinary shares represented by your ADSs may be delayed until the depositary receives satisfactory evidence of compliance with all applicable laws and regulations. Please keep in mind that the depositary will only accept ADSs for cancellation that represent a whole number of securities on deposit. You will have the right to withdraw the securities represented by your ADSs at any time except as a result of:

| • |     | temporary delays that may arise because (i) the transfer books for the ordinary shares or ADSs are closed, 
 or (ii) ordinary shares are immobilized on account of a shareholders’ meeting or a payment of dividends;   |

| • |     | obligations to pay fees, taxes and similar charges; or |

| • |     | restrictions imposed because of laws or regulations applicable to ADSs or the withdrawal of securities on 
 deposit.                                                                                                  |

The deposit agreement may not be modified to impair your right to withdraw the securities represented by your ADSs except to comply with mandatory provisions of law. Voting Rights As a holder, you generally have the right under the deposit agreement to instruct the depositary to exercise the voting rights for the ordinary shares represented by your ADSs. The voting rights of holders of ordinary shares are described in “Description of Share Capital—Articles of Association” in this prospectus. At our request, the depositary will distribute to you any notice of shareholders’ meeting received from us together with information explaining how to instruct the depositary to exercise the voting rights of the securities represented by ADSs. 41

Confidential Treatment Requested by Nucana plc Pursuant to 17 C.F.R. Section 200.83 If the depositary timely receives voting instructions from a holder of ADSs, it will endeavor to vote the securities (in person or by proxy) represented by the holder’s ADSs as follows:

| • |     | In the event of voting by show of hands, the depositary will vote (or cause the custodian to vote) all ordinary                                                    
 shares held on deposit at that time in accordance with the voting instructions received from a majority of holders of ADSs who provide timely voting instructions. |

| • |     | In the event of voting by poll, the depositary will vote (or cause the custodian to vote) the ordinary shares 
 held on deposit in accordance with the voting instructions received from the holders of ADSs.                 |

The depositary will not join in demanding a vote by poll. Securities for which no voting instructions have been received will