Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 194

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 194
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 in such jurisdictions only through
registered or licensed brokers or dealers. In addition, in certain states the shares may not be sold unless they have been registered or qualified for sale in the applicable state or an exemption from the registration or qualification requirement is
available and is complied with.

We have advised the Selling Stockholders that the anti-manipulation rules of Regulation M under the
Exchange Act may apply to sales of shares in the market and to the activities of the Selling Stockholders and their affiliates. In addition, we will make copies of this prospectus available to the Selling Stockholders for the purpose of satisfying
the prospectus delivery requirements of the Securities Act. The Selling Stockholders may indemnify any broker-dealer that participates in transactions involving the sale of the shares against certain liabilities, including liabilities arising under
the Securities Act.

Our Common Stock is currently listed on the Nasdaq Capital Market under the symbol “SCLX.”

122

DESCRIPTION OF THE EXCHANGE WARRANTS

The following summary of certain terms and provisions of the Exchange Warrants is not complete and is subject to, and qualified in its entirety by, the provisions of the Exchange Warrants. The form of Exchange Warrant is filed as an exhibit to the registration statement of which this prospectus forms a part.

Shares Issuable on Exercise

We are
offering by this prospectus 500,000 shares of Common Stock issuable upon exercise in full of all of the Exchange Warrants.

Exercise Price

The Exchange Warrants are exercisable at an exercise price equal to $40.00 per share of Common Stock.

The exercise price is subject to adjustment for any stock split, stock dividend, stock combination, recapitalization or similar event. The
exercise price is also subject to full-ratchet adjustment (down to the Exchange Warrant Exercise Price Floor of $36.40) in connection with a subsequent offering at a per share price less than the exercise price then in effect. The exercise price
cannot be lowered to less than Exchange Warrant Exercise Price Floor, unless stockholder approval is obtained to allow the Exchange Warrants to be exercised at a price that is lower than the Exchange Warrant Exercise Price Floor in accordance with
Nasdaq Listing Rules. The Company is under no obligation to seek or obtain such stockholder approval. The Exchange Warrants also provide for a voluntary adjustment to the exercise price, subject to certain conditions set forth therein, including
compliance with Nasdaq rules and having obtained the prior written consent of the Required Holders.

In the event of stock