Company: SCLXW
Filing Date: 2025-05-15
Form Type: 424B3
Source: 0000950170-25-071920
Chunk: 118

Company: Scilex Holding Co
Filing Date: 2025-05-15
Form: 424B3
Chunk 118
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 14, 2025 | Scilex Holding Company |                                                                     |
|:-------------|:-----------------------|:--------------------------------------------------------------------|
|              | By:                    | /s/ Jaisim Shah                                                     |
|              |                        | Jaisim Shah                                                         
 Chief Executive Officer and President (Principal Executive Officer) |

| May 14, 2025 |     |                                                      |
|:-------------|:----|:-----------------------------------------------------|
|              | By: | /s/ Stephen Ma                                       |
|              |     | Stephen Ma                                           
 Chief Financial Officer(Principal Financial Officer) |

<div align='center'>73</div>

Exhibit 31.1 CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER Pursuant to Rule 13a-14(a) adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Jaisim Shah, certify that: 1. I have reviewed this Quarterly Report on Form 10-Q of Scilex Holding Company; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report; 3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report; 4. The registrant’s other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have: (a) Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared; (b) Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in