Company: DRTSW
Filing Date: 2025-03-12
Form Type: 20-F
Source: 0001213900-25-023187
Chunk: 152

Company: Alpha Tau Medical Ltd.
Filing Date: 2025-03-12
Form: 20-F
Item: Item 4
Chunk 152
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 the sources,
and to ship the sources with their suitable applicator(s) to various destinations efficiently.

In our manufacturing facilities,
we employ different methods to produce extractable radium for scalable use. One such method, in a dry setup, utilizes an electrostatic
field to attract and isolate radium atoms. Specifically, we use the thorium as a flux-generating surface source to create a collecting
unit in which we place the Alpha DaRT sources for charging. The thorium decays into ionized radium atoms, which recoil from the thorium
generator and can be attracted or repelled using their inherent charge. The source is placed at a precise distance from the thorium generator
and an electrostatic field is placed across it to attract the radium to adhere to the source.

After the radium is collected,
each source is thermally treated or coated with a polymer to embed the radium securely on the outermost layers of the metallic matrix
of the source, while allowing the Radon-220 and subsequent daughter atoms to desorb, or detach from the source and enter the tumor. Each
Alpha DaRT source is individually measured to determine the overall Radium-224 activity on it and the desorption probability of Radon-220,
to calculate how much Radon-220 will diffuse into the tumor. It is then placed in an applicator to fit the prescribed treatment profile.

We have also devised a newer
method of radium production, which entails the collection of Radium-224 via a liquid solution of Thorium-228, allowing for more efficient
production with a higher output by significantly increasing the percentage yield of Radium-224 which is collected, as well as shortening
the time to collect Radium-224 onto each source. This method has the potential of increasing our existing capacity by a factor of 2 to
3.

Alpha DaRT sources are prepared
upon receiving an order from the clinician and are designed specifically for the treatment of an individual patient; specifically, the
number of active sources in each applicator is made to order to match the prescribed treatment plan. Supply of the Alpha DaRT sources
is carefully coordinated to account for a usable window up to 24 hours after receipt of the Alpha DaRT sources by the hospital, accounting
for the natural decay of the Radium-224 during shipment and intake. Pursuant to the United Nations guidance regarding the transport of
radioactive materials, the Alpha DaRT sources can be shipped by standard courier in Excepted Packages, which