Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 45

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 45
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or on any of the senior debt securities issued by TPC. The proceeds of any guaranteed senior debt securities sold by TUSFI hereunder will be lent on, distributed via dividend or otherwise transferred to other members of the Takeda group.

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### OFFERING INFORMATION
We may sell an indeterminate amount of senior debt securities from time to time through negotiated transactions with underwriters or with other persons, through a combination of such methods of sale or otherwise, including private sales. See “Plan of Distribution.” We may sell senior debt securities at varying prices determined at the time of sale or at negotiated or fixed prices, in each case as determined by agreement between us and underwriters, brokers, dealers or agents, or purchasers. For further information about the senior debt securities, see “Description of Senior Debt Securities and Guarantee.”

### RISK FACTORS
Before making a decision to invest in any of the senior debt securities, you should carefully consider the risks described under “Risk Factors” in Takeda’s most recent annual report on Form 20-F and in any updates to those risk factors in its current reports on Form 6-K that are incorporated herein and in the applicable prospectus supplement, together with all of the other information appearing or incorporated by reference in this prospectus and any applicable prospectus supplement or free writing prospectus prepared by or on behalf of us or to which we refer you, in light of your particular investment objectives and financial circumstances.

### USE OF PROCEEDS
We intend to use the net proceeds from the sale of the senior debt securities described in this prospectus for general corporate purposes, unless otherwise described in the applicable prospectus supplement or free writing prospectus.

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### CAPITALIZATION AND INDEBTEDNESS
The following table shows Takeda’s consolidated capitalization and indebtedness as of March 31, 2025.

This table should be read together with Takeda’s consolidated financial statements, including the notes thereto, and the other financial data appearing elsewhere, or incorporated by reference, in this prospectus.

|                                              |     | As of March 31, 2025 |          |
|:---------------------------------------------|:----|:---------------------|---------:|
|                                              |     | -billions of yen     |          |
| Short-term Debt:                             |     |                      |          |
| Current portion of bonds and loans           |     | ¥                    |    548.9 |
| Long