Company: MDCXW
Filing Date: 2025-09-29
Form Type: S-1
Source: 0001062993-25-015839
Chunk: 116

Company: Medicus Pharma Ltd.
Filing Date: 2025-09-29
Form: S-1
Chunk 116
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. The centrifuge is run for 30 minutes at 5,500 rpm at 15C. |
| Doxorubicin stability                   |     | Temperature maintained within centrifuge at 15C that impacts drying.                                              
 Refrigeration of arrays once fabricated at 2-8°C                                                                  |

<div align='center'>72</div>

The flow chart, below, describes in more detail the critical steps and manufacturing parameters. A summary narrative of the process is provided on subsequent pages.

<div align='center'>Figure 2. Manufacturing flow chart</div>

Manufacturing Process Equipment

The equipment used to fabricate the arrays is listed in the table below:

Equipment Used to Fabricate Arrays

| Description            |     | Supplier     |     | Model/Part Number/Print                           |
| Centrifuge             |     | Thermofisher |     | Sorvall Lynx 4000                                 |
| Rotor                  |     | Thermofisher |     | BioFlex HC (PN 75003000Q502807)                   |
| Rotor Bucket           |     | Thermofisher |     | BioFlex HC (PN 75003000Q502807)                   |
| Bucket Lid with Gasket |     | Thermofisher |     | BioFlex HC Lid (PN 75007309Q502807)               |
| Bucket Insert          |     | GFE LLC      |     | GFE Print "Lynx Square Tool Holder Rev R1"        |
| Casting Mask           |     | GFE LLC      |     | GFE Print "Array Rev X6 Production Mold Frame"    |
| Casting Sleeve         |     | GFE LLC      |     | GFE Print "Array Rev X6 MNA Master Sleeve Rev E0" |
| Production Mold        |     | GFE LLC      |     | GFE Print "Array Rev X6 Production Mold Rev E0"   |

<div align='center'>73</div>

In an initial step, a master mold is fabricated by a milling process under CAD/CAM of a suitable material such as an acrylic or a metal alloy, rendering the required geometry for the microneedles. Once fabricated, the master mold is stored for future rendering of production molds as needed. The masters are wrapped in a clean-room towel for protection and stored in individually labeled rigid containers. The production molds are stored 4 per glass container labeled with revision codes. All materials are stored in a final secondary container labeled masters and production molds.

The master mold is