Company: CYTK
Filing Date: 2025-02-27
Form Type: S-3ASR
Source: 0001193125-25-039426
Chunk: 34

Company: CYTOKINETICS INC
Filing Date: 2025-02-27
Form: S-3ASR
Chunk 34
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 with another institution that does. Thus, an investor whose security is represented by a global security will not be a holder of the security, but only an indirect holder of a beneficial interest in the global security. If the prospectus supplement for a particular security indicates that the security will be issued in global security form only, then the security will be represented by a global security at all times unless and until the global security is terminated. If termination occurs, we may issue the securities through another book-entry clearing system or decide that the securities may no longer be held through any book-entry clearing system. Special Considerations for Global Securities The rights of an indirect holder relating to a global security will be governed by the account rules of the investor’s financial institution and of the depositary, as well as general laws relating to securities transfers. We do not recognize an indirect holder as a holder of securities and instead deal only with the depositary that holds the global security. 23

If securities are issued only in the form of a global security, an investor should be aware of the following:

| • |     | an investor cannot cause the securities to be registered in his or her name, and cannot obtain non-global certificates for his or her interest in the securities, except in the special situations we describe below; |

| • |     | an investor will be an indirect holder and must look to his or her own bank or broker for payments on the 
 securities and protection of his or her legal rights relating to the securities, as we describe above;    |

| • |     | an investor may not be able to sell interests in the securities to some insurance companies and to other 
 institutions that are required by law to own their securities in non-book-entry form;                    |

| • |     | an investor may not be able to pledge his or her interest in a global security in circumstances where                                                
 certificates representing the securities must be delivered to the lender or other beneficiary of the pledge in order for the pledge to be effective; |

| • |     | the depositary’s policies, which may change from time to time, will govern payments, transfers, exchanges 
 and other matters relating to an investor’s interest in a global security;                                |

| • |     | we and any applicable trustee have no responsibility for any aspect of the depositary’s actions or for its                    
 records of ownership interests in a global security, nor do we or any applicable trustee supervise the depositary in any way; |

| • |     | the depositary may, and we understand that DTC