Company: PSTV
Filing Date: 2025-08-12
Form Type: S-1
Source: 0001193125-25-178940
Chunk: 35

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-08-12
Form: S-1
Chunk 35
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 each share of Series C Preferred Stock before any distribution or payment shall be made to the holders of any junior securities.

Redemption Rights.We are not obligated to redeem or repurchase any shares of Series C Preferred Stock. Shares of Series C Preferred
Stock are not otherwise entitled to any redemption rights, or mandatory sinking fund or analogous fund provisions.

Anti-Takeover Effects of Delaware Law and Our Certificate of Incorporation and Bylaws

Certain provisions of Delaware law, our amended and restated certificate of incorporation, as
amended, and our amended and restated bylaws could have the effect of delaying, deferring or discouraging another party from acquiring control of us. These provisions, which are summarized below, are expected to discourage certain types

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of coercive takeover practices and inadequate takeover bids. These provisions are also designed, in part, to encourage persons seeking to acquire control of us to first negotiate with our board of directors. Certificate of Incorporation and Bylaws. Our amended and restated certificate of incorporation, as amended, and amended and restated bylaws include provisions that:

| • |     | authorize the board of directors to issue, without stockholder approval, blank-check preferred stock with such                                                                                                                                           
 designations, powers, preferences and other rights and qualifications, limitations or restrictions as our board of directors may authorize, which preferred stock could decrease the amount of earnings and assets available for distribution to holders 
 of our common stock or adversely affect the rights and powers, including voting rights, of the holders of our common stock;                                                                                                                              |

| • |     | establish advance notice requirements for stockholder nominations of directors and for stockholder proposals that 
 can be acted on at stockholder meetings;                                                                          |

| • |     | limit who may call stockholder meetings; |

| • |     | require that any action to be taken by our stockholders be effected at a duly called annual or special meeting 
 and not by written consent;                                                                                    |

| • |     | provide that vacancies on our board of directors may be filled only by a majority of directors then in office, 
 even if less than a quorum; and                                                                                |

| • |     | authorize us to indemnify officers and directors against losses that they may incur in investigations and legal           
 proceedings resulting from their services to us, which may include services in connection with takeover defense measures. |

Delaware anti-takeover statute. We are subject to Section 203 of the DGCL, which prohibits persons deemed to be “interested stockholders” from engaging in a