Company: PSTV
Filing Date: 2025-08-04
Form Type: DRS
Source: 0000950123-25-006916
Chunk: 0

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-08-04
Form: DRS
Chunk 0
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Confidential Treatment Requested by Plus Therapeutics, Inc. Pursuant to 17 C.F.R. Section 200.83 As confidentially submitted to the U.S. Securities and Exchange Commission on August 1, 2025. This draft registration statement has not been publicly filed with the U.S. Securities and Exchange Commission and all information herein remains strictly confidential. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 PLUS THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter)

| Delaware                        |     |                         2834 |     | 33-0827593            |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -Primary Standard Industrial 
   Classification Code Number |     | -I.R.S. Employer      
 Identification Number |

2710 Reed Road, Suite 160 Houston, Texas 77002 (737) 255-7194 (Address, including zip code, and telephone number, including area code, of Registrant’s principal executive offices) Andrew Sims Chief Financial Officer Plus Therapeutics, Inc. 2710 Reed Road, Suite 160 Houston, Texas 77002 (737) 255-7194 (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies to: David E. Danovitch Aaron M. Schleicher Sullivan & Worcester LLP 1251 Avenue of the Americas New York, New York 10020 (212) 660-3060 Approximate date of commencement of proposed sale to the public: From time to time after this registration statement becomes effective, as determined by the selling stockholder. If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act, check the following box: ☒ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to