Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 190

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 190
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es, pledgees, transferees or other successors in interest selling securities received after the date of this prospectus from a Selling Stockholder as a gift, pledge, partnership distribution or other transfer. The Selling Stockholders will act independently of us in making decisions with respect to the timing, manner and size of each sale. Such sales may be made on one or more exchanges or in the over-the-countermarket or otherwise, at prices and under terms then prevailing or at prices related to the then current market price or in negotiated transactions. Each Selling Stockholder reserves the right to accept and, together with its respective agents, to reject, any proposed purchase of securities to be made directly or through agents. The Selling Stockholders and any of their permitted transferees may sell their securities offered by this prospectus on any stock exchange, market or trading facility on which the securities are traded or in private transactions. If underwriters are used in the sale, such underwriters will acquire the shares for their own account. These sales may be at a fixed price or varying prices, which may be changed, or at market prices prevailing at the time of sale, at prices relating to prevailing market prices or at negotiated prices. The securities may be offered to the public through underwriting syndicates represented by managing underwriters or by underwriters without a syndicate. The obligations of the underwriters to purchase the securities will be subject to certain conditions. The Selling Stockholders may sell their shares and warrants by one or more of, or a combination of, the following methods:

| • |     | purchases by a broker-dealer as principal and resale by such broker-dealer for its own account pursuant to this 
 prospectus;                                                                                                     |

119

| • |     | ordinary brokerage transactions and transactions in which the broker solicits purchasers; |

| • |     | block trades in which the broker-dealer so engaged will attempt to sell the offered securities as agent but may 
 position and resell a portion of the block as principal to facilitate the transaction;                          |

| • |     | an over-the-counter distribution                                                                               
 in accordance with the rules of the applicable exchange on which the shares are listed or admitted to trading; |

| • |     | through trading plans entered into by a Selling Stockholder pursuant to Rule                                                                                                                                   
 10b5-1 under the Exchange Act, that are in place at the time of an offering pursuant to this prospectus and any applicable prospectus supplement hereto that provide for periodic sales of their securities on 
 the basis of