Company: TVRD
Filing Date: 2025-02-14
Form Type: 424B3
Source: 0001104659-25-014310
Chunk: 959

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-02-14
Form: 424B3
Chunk 959
---
 | Exhibit B-2      | ​ | ​ | Form of Parent Stockholder Support Agreement  | ​ |
| ​ | Exhibit C-1      | ​ | ​ | Form of Company Lock-Up Agreement             | ​ |
| ​ | Exhibit C-2      | ​ | ​ | Form of Parent Lock-Up Agreement              | ​ |
| ​ | Exhibit D        | ​ | ​ | Form of Company Stockholder Written Consent   | ​ |
| ​ | Exhibit E        | ​ | ​ | Form of 2025 Equity Incentive Plan            | ​ |
| ​ | Exhibit F        | ​ | ​ | Form of 2025 Employee Stock Purchase Plan     | ​ |
| ​ | Exhibit G        | ​ | ​ | Form of CSL Asset Purchase Agreement          | ​ |
| ​ | Schedules:       | ​ | ​ | ​                                             | ​ |
| ​ | Schedule A       | ​ | ​ | Company Signatories                           | ​ |
| ​ | Schedule I       | ​ | ​ | Exchange Ratio                                | ​ |
| ​ | Schedule II      | ​ | ​ | Parent Net Cash                               | ​ |
| ​ | Schedule 5.6(a)  | ​ | ​ | Indemnification Agreements                    | ​ |
| ​ | Schedule 5.11    | ​ | ​ | Directors and Officers                        | ​ |
| ​ | Schedule 5.12(a) | ​ | ​ | Investor Agreements                           | ​ |
| ​ | Schedule 5.12(b) | ​ | ​ | Specified Parent Contracts                    | ​ |

A-iv

TABLE OF CONTENTS

### AGREEMENT AND PLAN OF MERGER AND REORGANIZATION

### THIS AGREEMENT AND PLAN OF MERGER AND REORGANIZATION
(this “

#### Agreement
”) is made and entered into as of December 17, 2024, by and among

#### CARA THERAPEUTICS, INC.
, a Delaware corporation (“

#### Parent
”),

#### CT CONVERGENCE MERGER SUB, INC.
, a Delaware corporation and wholly-owned subsidiary of Parent (“

#### Merger Sub
”), and

#### TVARDI THERAPEUTICS, INC.
, a Delaware corporation (the “

#### Company
”). Certain capitalized terms used in this Agreement are defined in

#### Exhibit A
.

### RECITALS
A. Parent and the Company intend to effect a merger of Merger Sub with and into the Company (the “

#### Merger