Company: CERO
Filing Date: 2025-07-28
Form Type: S-8
Source: 0001213900-25-068283
Chunk: 1

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-07-28
Form: S-8
Chunk 1
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 financial accounting standards provided pursuant
to Section 7(a)(2)(B) of the Securities Act. ☐

<div align='center'>PART I.

EXPLANATORY NOTE</div>

This registration statement on Form S-8 (this
“Registration Statement”), is being filed by CERo Therapeutics Holdings, Inc. (the “Registrant”), for the purpose
of registering an additional (1) 109,485 shares of the Registrant’s common stock, par value $0.0001 per share (“Common Stock”),
issuable pursuant to the CERo Therapeutics Holdings, Inc. 2024 Equity Incentive Plan (the “2024 Plan”), and (2) 510 shares
of Common Stock, issuable pursuant to the CERo Therapeutics Holdings, Inc. 2024 Employee Stock Purchase Plan (the “2024 ESPP”)
(in each case as adjusted for each of the reverse stock split of 1-for-100 effected by the Registrant effective as of January 8, 2025
and the reverse stock split of 1-for-20 effected by the Registrant effective as of June 13, 2025), as additional shares of Common Stock
issuable under each of the 2024 Plan and the 2024 ESPP for which shares of Common Stock have previously been registered pursuant to a
Registration Statement on Form S-8 which has previously been filed and is effective. Accordingly, this Registration Statement on Form
S-8 incorporates by reference the contents of the Registration Statement on Form S-8 (File No. 333-283698) filed with the Securities
and Exchange Commission on December 9, 2024 by the Registrant, relating to the 2024 Plan and 2024 ESPP, except, in each case, for “Item
8. Exhibits.”

<div align='center'>1

PART II.

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>

Item 8. Exhibits.

EXHIBIT INDEX

| Exhibit 
 No.     
 4.1     
 4.2     |     | Description                                                                                                                                                                                                           
 Second Amended and Restated Certificate of Incorporation of CERo Therapeutics Holdings, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K/A, filed on February 27, 2024). 
 Second Amended and Restated Bylaws of CERo Therapeutics Holdings