Company: ENTXW
Filing Date: 2025-05-30
Form Type: S-8
Source: 0001178913-25-002027
Chunk: 1

Company: Entera Bio Ltd.
Filing Date: 2025-05-30
Form: S-8
Chunk 1
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0000769 per share (“ Ordinary Shares”), of the Registrant under the Entera Bio Ltd. 2018 Equity Incentive Plan (the “ Plan”). The number of Ordinary Shares available for issuance under the Plan is subject to an automatic annual increase on the first day of each calendar year during the term of the Plan equal to the lesser of (i) five percent (5%) of the number of outstanding Ordinary Shares on the last day of the immediately preceding fiscal year and (ii) such smaller number of shares as determined by the Registrant’s Board of Directors (the “ Board”), in its discretion (the “ Evergreen Provision”). Consequently, pursuant to the Evergreen Provision, the number of Ordinary Shares available for issuance under the Plan increased by an aggregate of 1,941,859 shares on January 1, 2025, which shares are registered under this Registration Statement. Pursuant to Instruction E of Form S-8, the contents of the Registrant’s prior registration statement on Form S-8 registering Ordinary Shares under the Plan (File No. 333-227488) (the “ Prior Registration Statement”) is hereby incorporated by reference herein, and the information otherwise required by Form S-8 is omitted, except that the provisions contained in Part II of the Prior Registration Statement are modified as set forth in this Registration Statement. PART II

| Item 3. | Incorporation of Documents by Reference. |

The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed with the Securities and Exchange Commission (the “ Commission”):

| (d) | The Registrant’s Registration Statement onForm 8-Afiled with the Commission on June 25, 2018 (File No. 001-38556), in which there is                                                                                                                                                                          
 described the terms, rights and provisions applicable to the Ordinary Shares, including any amendment or report filed for the purpose of updating such description, including the description of the Ordinary Shares filed asExhibit 4.1to the Registrant’s Annual Report onForm 10-Kfiled on March 31, 2023. |

Additionally, all documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act (not including any information furnished under Items 2.02, 7.01 or 9.01 of Form 8-K or any other information that is identified as, or deemed, “furnished” rather than filed, which information is not incorporated