Company: NYXH
Filing Date: 2025-03-20
Form Type: F-3
Source: 0001104659-25-026217
Chunk: 57

Company: Nyxoah SA
Filing Date: 2025-03-20
Form: F-3
Chunk 57
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 for sales of ordinary shares sold pursuant to the Sales Agreement will be an amount equal to 3.0% of the gross proceeds of any ordinary shares sold under the Sales Agreement. In connection with the sale of the ordinary shares on our behalf, Cantor will be deemed to be an “underwriter” within the meaning of the Securities Act and the compensation of Cantor will be deemed to be underwriting commissions or discounts. We have also agreed to provide indemnification and contribution to Cantor with respect to certain liabilities, including liabilities under the Securities Act or the Exchange Act of 1934, as amended, or the Exchange Act. See “Plan of Distribution” beginning on page S-30for additional information regarding the compensation to be paid to Cantor.

Our business and an investment in our ordinary shares involve significant risks. These risks are described under the caption “Risks Related to This Offering” beginning on page S-5of this prospectus supplement under the caption “Risk Factors” and in the documents incorporated by reference into this prospectus supplement.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus supplement. Any representation to the contrary is a criminal offense.**

#### Cantor
<div align='center'>The date of this prospectus supplement is , 2025.</div>

TABLE OF CONTENTS

TABLE OF CONTENTS

| ​ | ABOUT THIS PROSPECTUS SUPPLEMENT                                     | ​ | ​ | ​ | ​ | S-1  | ​ | ​ |
| ​ | PRESENTATION OF FINANCIAL INFORMATION                                | ​ | ​ | ​ | ​ | S-2  | ​ | ​ |
| ​ | PROSPECTUS SUMMARY                                                   | ​ | ​ | ​ | ​ | S-3  | ​ | ​ |
| ​ | THE OFFERING                                                         | ​ | ​ | ​ | ​ | S-4  | ​ | ​ |
| ​ | RISK FACTORS                                                         | ​ | ​ | ​ | ​ | S-5  | ​ | ​ |
| ​ | SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS                    | ​ | ​ | ​ | ​ | S-8  | ​ | ​ |
| ​ | USE OF PROCEEDS                                                      | ​ | ​ | ​ | ​ | S-10 | ​ | ​ |
| ​ | CAPITALIZATION                                                       | ​ | ​ | ​ | ​ | S-11 | ​ | ​ |
| ​ | D