Company: SHPH
Filing Date: 2025-04-10
Form Type: PRER14A
Source: 0001641172-25-003635
Chunk: 37

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-04-10
Form: PRER14A
Chunk 37
---
 in lieu of fractional shares based on their particular circumstances.

A U.S. Holder may be subject to information reporting with respect to any cash received in lieu of a fractional share in the Reverse Stock Split. U.S. Holders who are subject to information reporting and who do not provide a correct taxpayer identification number and other required information (such as by submitting a properly completed Internal Revenue Service Form W-9) may also be subject to backup withholding at the applicable rate. Any amount withheld under such rules is not an additional tax and may be refunded or credited against the U.S. Holder’s U.S. federal income tax liability, provided that the required information is properly furnished in a timely manner to the Internal Revenue Service. Stockholders should consult their tax advisors regarding their qualification for an exemption from backup withholding and the procedures for obtaining such an exemption.

| 26 |

Proposal No. 5: The approval of the first amendment to Shuttle Pharmaceuticals Holdings, Inc.’s 2018 Equity Incentive Plan to increase the amount of shares reserved for issuance by 5,000,000 shares of common stock.

| What                                  
 am I voting on and how should I vote? |     | You                                                                                                                              
 are being asked to approve the first amendment to Shuttle Pharmaceuticals Holdings, Inc.’s 2018 Equity Incentive Plan to         
 increase the amount of shares reserved for issuance by 5,000,000 shares of common stock. The Board of Directors believes that    
 increase the number of shares reserved under the Company’s 2018 Equity Incentive Plan is in the best interest of the Company     
 and its stockholders as it will allow for the issuance of additional equity incentive awards to the Company’s employees,         
 directors and consultants.                                                                                                       
 The                                                                                                                              
 Board of Directors therefore recommends you vote “FOR” the approval of the first amendment to Shuttle Pharmaceuticals            
 Holdings, Inc.’s 2018 Equity Incentive Plan to increase the amount of shares reserved for issuance by 5,000,000 shares of common 
 stock.                                                                                                                           |

We are seeking stockholder approval of the first
amendment (the “First Amendment”) to the Company’s 2018 Plan to increase the amount of shares reserved for issuance
under the 2018 Plan by 5,000,000 shares. The 2018 Plan provides eligible officers, directors, key employees and other key individuals
an incentive to contribute to the success of the Company and to operate and manage our business in a manner that provides for the Company’s
long-term