Company: HCWB
Filing Date: 2025-05-13
Form Type: S-1/A
Source: 0001193125-25-118837
Chunk: 0

Company: HCW Biologics Inc.
Filing Date: 2025-05-13
Form: S-1/A
Chunk 0
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As filed with the U.S. Securities and Exchange Commission on May 13, 2025 Registration No. 333-287136 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 Pre-Effective Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 HCW BIOLOGICS INC. (Exact name of Registrant as specified in its charter)

| Delaware                        |     |                        2834 |     | 82-5024477            |
| (State or Other Jurisdiction of 
 Incorporation or Organization)  |     | Primary Standard Industrial 
  Classification Code Number |     | -I.R.S. Employer      
 Identification Number |

2929 N Commerce Parkway Miramar, FL 33025 (954) 842-2024 Address, including zip code, and telephone number, including area code, of Registrant’s principal executive offices Hing C. Wong, Ph.D. Chief Executive Officer HCW Biologics Inc. 2929 N Commerce Parkway Miramar, FL 33025 (954) 842-2024 Name, Address Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service With a copy to:

| James Groth                               
 Clark Hill PLC 130 E.                     
 Randolph St., Ste. 3900 Chicago, IL 60601 
 (312) 985-5900                            |     | Randolf Katz                               
 Clark Hill PLC 555 S.                      
 Flower St., 24 Floor Los Angeles, CA 90071 
 (213) 891-9100                             |

Barry I. Grossman, Esq. Matthew Bernstein, Esq. Justin Grossman, Esq. Ellenoff Grossman & Schole LLP 1345 Avenue of the Americas New York, New York 10105 Tel: (212) 370-1300 Approximate Date of Commencement of Proposed Sale to the Public:As soon as practicable after this registration statement becomes effective. If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. ☑ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post