Company: APM
Filing Date: 2025-10-14
Form Type: 424B5
Source: 0001213900-25-098635
Chunk: 1

Company: Aptorum Group Ltd
Filing Date: 2025-10-14
Form: 424B5
Chunk 1
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 incident
to the registration, offering and sale of the Shares under this prospectus supplement and the accompanying base prospectus.

The aggregate market value of our
outstanding Class A Ordinary Shares held by non-affiliates, or public float, as of October 10, 2025, was approximately US$15.28
million, which was calculated based on 3,595,470 Class A Ordinary Shares and Class B Ordinary Shares held by non-affiliates as of
October 10, 2025, and a per share price of US$4.25, which was the closing price of our Class A Ordinary Shares on Nasdaq on
August 21, 2025. Pursuant to General Instruction I.B.5 of Form F-3, in no event will we sell the securities covered hereby in a
public primary offering with a value exceeding more than one-third of the aggregate market value of our ordinary shares in any
12-month period so long as the aggregate market value of our outstanding ordinary shares held by non-affiliates remains below
US$75,000,000. During the 12 calendar months prior to and including the date of this prospectus supplement, we have sold $3,070,000
worth of securities in a public primary offering pursuant to General Instruction I.B.5 of Form F-3.

Investors are cautioned that you are
buying shares of a Cayman Islands, Hong Kong, or Nevada-based operating companies but instead are buying shares of a Cayman Islands holding
company with operations conducted by our subsidiaries based in the Cayman Islands, Hong Kong, and Nevada, and that this structure involves
unique risks to investors.

This is an offering of the Class A ordinary shares
of the Cayman Islands holding company. We conduct our business through the subsidiaries in Cayman Islands, Hong Kong, and Nevada. You
will not and may never have direct ownership in the operating entities based in Cayman Islands, Hong Kong, and Nevada.

Throughout this prospectus, unless the context
indicates otherwise, references to “us,” “our,” “Aptorum,” “we,” the “Company,”
the “group” and similar designations refer to Aptorum Group Limited, a Cayman Islands exempted company with limited liability.
References to “Subsidiaries,” or “Operating Subsidiaries” refer to the Aptorum’s subsidiaries established
under the laws of the Cayman Islands, Hong Kong, and Nevada. References to “Group” are to