Company: TEM
Filing Date: 2025-08-08
Form Type: S-3ASR
Source: 0001193125-25-175993
Chunk: 7

Company: Tempus AI, Inc.
Filing Date: 2025-08-08
Form: S-3ASR
Chunk 7
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 and medical 
 conference presentations;                                                                                      |

| • |     | the implementation of our business model and strategic plans for our products, technologies and businesses; |

| • |     | competitive companies and technologies and our industry; |

| • |     | the potential of intelligent diagnostics to be disruptive across a broad set of disease areas and the clinical 
 trial process;                                                                                                 |

| • |     | our ability to manage and grow our business by expanding our sales to existing customers or introducing our 
 products to new customers;                                                                                  |

| • |     | the impact of macroeconomic conditions, including new and potential tariffs, on us and our customers; |

| • |     | third-party payer reimbursement and coverage decisions, including our strategy to increase reimbursement; |

| • |     | our ability to establish and maintain intellectual property protection for our products or avoid claims of 
 infringement;                                                                                              |

| • |     | potential effects of evolving and/or extensive government regulation; |

| • |     | the timing or likelihood of regulatory filings and approvals; |

iii

| • |     | our ability to hire and retain key personnel; |

| • |     | our ability to expand internationally, including through our joint venture, SB Tempus Corp. in Japan; |

| • |     | our ability to successfully acquire businesses, form joint ventures or make investments in companies or                                     
 technologies, including our ability to realize the expected benefits of our acquisitions of Ambry Genetics Corporation and Deep 6 AI, Inc.; |

| • |     | our ability to protect and enforce our intellectual property rights, including our trade secret protected 
 proprietary rights in our platform;                                                                       |

| • |     | our ability to service or pay down existing or future debt obligations; |

| • |     | the outcome of pending or threatened litigation; |

| • |     | our anticipated cash needs and our needs for additional financing; and |

| • |     | anticipated trends and challenges in our business and the markets in which we operate. |

You should not rely on forward-looking statements as predictions of future events. We have based the forward-looking statements contained in, or incorporated by reference into, this prospectus primarily on our current expectations and projections about future events and trends that we believe may affect our business, financial condition and operating results. The outcome of the events described in these forward-looking statements is subject to risks, uncertainties and other factors described in, or incorporated by reference into, the sections titled “Risk Factors” in this prospectus and any applicable prospectus supplement