Company: LEU
Filing Date: 2025-11-06
Form Type: 424B5
Source: 0001104659-25-107429
Chunk: 1

Company: CENTRUS ENERGY CORP
Filing Date: 2025-11-06
Form: 424B5
Chunk 1
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 any
specific amount of shares of our Class A Common Stock, but will act as our sales agents using reasonable efforts consistent with
their normal trading and sales practices. There is no arrangement for funds to be received in any escrow, trust or similar arrangement.

The Agents will be entitled
to compensation at a commission rate equal to 1.5% of the gross sales price per share of our Class A Common Stock sold through it
or to them as sales agent under the Sales Agreement. In connection with the sale of our Class A Common Stock on our behalf, an Agent
may be deemed to be an “underwriter” within the meaning of the Securities Act of 1933, as amended (the “Securities
Act”) and the compensation of the Agents may be deemed to be underwriting commissions or discounts. We have also agreed to provide
indemnification and contribution to the Agents with respect to certain liabilities, including liabilities under the Securities Act.

Investing in our Class A Common Stock involves a high degree of risk. Before buying shares of our Class A Common Stock, you should carefully consider the risk factors described in “Risk Factors” beginning on page S- 4of this prospectus supplement, the section captioned “Item 1A—Risk Factors” in our most recently filed Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q, which are incorporated by reference into this prospectus supplement, and under similar headings in the other documents that are filed after the date hereof and incorporated by reference into this prospectus supplement.

Neither the Securities and Exchange Commission (the “SEC”) nor any state securities commission has approved or disapproved of these securities or determined if this prospectus supplement is truthful or complete. Any representation to the contrary is a criminal offense.

| Barclays            | Citi       | UBS Investment Bank | Evercore ISI    |
| B. Riley Securities | Guggenheim 
 Securities | MUFG                | William         
 Blair           |
| Lake                
 Street              |            |                     | Northland       
 Capital Markets |

<div align='center'>The date of this prospectus supplement is November 6,
2025.

TABLE OF CONTENTS</div>

|                                           |     | Page  |
| ABOUT                                     
 THIS PROSPECTUS SUPPLEMENT                |     | S-iii |
| SPECIAL                                   
 NOTE REGARDING FORWARD-LOOKING STATEMENTS |     | S-iv  |
| PROSPECTUS                                
 SUPPLEMENT SUMMARY                        |     | S-1   |