Company: LENZ
Filing Date: 2025-03-19
Form Type: S-8
Source: 0001628280-25-013856
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Company: LENZ Therapeutics, Inc.
Filing Date: 2025-03-19
Form: S-8
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<div align='center'>As filed with the Securities and Exchange Commission on March 19, 2025</div>

#### Registration No. 333-

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

#### FORM S-8

### REGISTRATION STATEMENT

#### Under

#### The Securities Act of 1933

#### LENZ THERAPEUTICS, INC.
<div align='center'>(Exact name of Registrant as specified in its charter)</div>

| Delaware                        |     | 84-4867570            |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -I.R.S. Employer      
 Identification Number |

| 201 Lomas Santa Fe Drive, Suite 300                          
 Solana Beach, California 92075                               |
| (Address of Principal Executive Offices, including zip code) |

| LENZ Therapeutics, Inc. 2024 Equity Incentive Plan        
 LENZ Therapeutics, Inc. 2024 Employee Stock Purchase Plan |
| (Full title of the plan)                                  |

| Evert Schimmelpennink                                                           
 Chief Executive Officer                                                         
 201 Lomas Santa Fe Drive, Suite 300                                             
 Solana Beach, California 92075                                                  
 (858) 925-7000                                                                  |
| (Name, address and telephone number, including area code, of agent for service) |

<div align='center'>Copies to:</div>

| Dan Koeppen                            
 Jennifer Fang                          
 Robert L. Wernli, Jr.                  
 Ben Capps                              
 Wilson Sonsini Goodrich & Rosati, P.C. 
 12235 El Camino Real                   
 San Diego, California 92130            
 (858) 350-2300                         |

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer |     | ☐ |     | Accelerated filer         |     | ☐ |
| Non-accelerated filer   |     | ☒ |     | Smaller reporting company |     | ☒ |
|                         |     |   |     | Emerging growth