Company: SMNR
Filing Date: 2025-08-13
Form Type: 424B3
Source: 0001193125-25-179226
Chunk: 418

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-08-13
Form: 424B3
Chunk 418
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 Denali 
 Ordinary Shares or, after the Business Combination, New Semnur Common Stock;                              |

| • |     | holders holding Denali securities or, after the Business Combination, Domesticated Denali securities as a                                                                    
 position in a “straddle,” as part of a “synthetic security” or “hedge,” as part of a “conversion transaction,” or other integrated investment or risk reduction transaction; |

| • |     | controlled foreign corporations, passive foreign investment companies, or foreign corporations with respect to                    
 which there are one or more United States shareholders within the meaning of Treasury Regulation Section 1.367(b)–3(b)(1)(ii); or |

| • |     | the Sponsors or their affiliates. |

As used in this proxy statement/prospectus, the term “U.S. Holder” means a beneficial owner of Denali securities and, after the Business Combination, Domesticated Denali securities that is, for U.S. federal income tax purposes:

| • |     | an individual who is a citizen or resident of the United States; |

| • |     | a corporation (or other entity that is classified as a corporation for U.S. federal income tax purposes) that is 
 created or organized in or under the laws of the United States or any State thereof or the District of Columbia; |

| • |     | an estate, the income of which is subject to U.S. federal income tax regardless of its source; or |

| • |     | a trust (i) if a court within the United States is able to exercise primary supervision over the                                                                                                                                                    
 administration of the trust and one or more U.S. persons have the authority to control all substantial decisions of the trust, or (ii) that has a valid election in effect under applicable Treasury Regulations to be treated as a U.S. person for 
 U.S. federal income tax purposes.                                                                                                                                                                                                                   |

A “Non–U.S. Holder” means a beneficial owner of Denali securities or, after the Domestication, Domesticated Denali securities, that is neither a U.S. Holder nor a partnership (or an entity or arrangement treated as a partnership) for U.S. federal income tax purposes. If a partnership, including for this purpose any entity or arrangement that is treated as a partnership or other flow-throughentity for U.S. federal income tax purposes, holds Denali securities or, after the Domestication, Domesticated Denali securities, the U.S. federal income tax treatment of a partner in