Company: SFNC
Filing Date: 2025-09-10
Form Type: 424B5
Source: 0001193125-25-200113
Chunk: 85

Company: SIMMONS FIRST NATIONAL CORP
Filing Date: 2025-09-10
Form: 424B5
Chunk 85
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2024, which is incorporated herein by reference, FORVIS, LLP has applied limited procedures in accordance with professional standards
for review of such information. However, as stated in its separate report included therein, FORVIS, LLP did not audit and it does not express an opinion on that interim financial information. Because of the limited nature of the review procedures
applied, the degree of reliance on its reports on such information should be restricted. Pursuant to Rule 436(c) under the Securities Act, this report on the Company’s unaudited interim consolidated financial information should not be
considered a part of the registration statement prepared or certified by its independent registered public accounting firm within the meaning of Sections 7 and 11 of the Securities Act.

4

$325,000,000 Simmons First National Corporation 6.25% Fixed-to-FloatingSubordinated Notes due 2035 Prospectus Supplement September 9, 2025 Joint Book-Running Managers

| Keefe, Bruyette & Woods |     | Morgan Stanley |
| A Stifel Company        |     |                |

Co-Managers

| Piper Sandler |     | Raymond James |     | Stephens Inc. |