Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 2

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 2
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 an exercise price of $20.00 per share. For more information regarding the September 2025 Warrants, see the section titled “Description of the September 2025 Warrants”.

The November 2025 Investor Warrant was issued on November 25, 2025, pursuant to a Warrant Inducement
Agreement (the “Warrant Inducement Agreement”) (a copy of which is filed as an exhibit to the registration statement of which this prospectus forms a part) that we entered into on November 23, 2025 with a certain institutional
investor (the “Exercising Investor”). Pursuant to the Warrant Inducement Agreement, the Exercising Investor exercised (the “Exercise”) warrants to purchase an aggregate of (i) 428,572 shares of Common Stock
previously issued to such investor on April 25, 2024 and (b) 475,824 shares of Common Stock previously issued to such investor on December 13, 2024, in exchange for, among other things, the Company’s agreement to
issue the November 2025 Investor Warrant with an exercise price of $29.00 per share. In connection with the Exercise, the Company also issued the November 2025 Placement Agent Warrants with an exercise price of $29.00 per share to StockBlock
Securities LLC and its affiliate, Rodman & Renshaw LLC, or their respective designees, who served as the placement agents in connection with such transaction. For more information regarding the November 2025 Warrants, see the section titled
“Description of the November 2025 Warrants”.

Our Common Stock is listed on the Nasdaq Capital Market under the symbol
“SCLX”. On December 26, 2025, the last reported sales price per share of our Common Stock was $14.10.

On April 15,
2025, we effected a reverse stock split of our Common Stock at a ratio of 1-for-35 (the “Reverse Stock Split”). Unless otherwise noted, the share and per
share information in this prospectus reflects the effect of the Reverse Stock Split.

We are an “emerging growth company” as
that term is used in the Jumpstart Our Business Startups Act of 2012 (the “JOBS Act”) and, as such, we have elected to comply with certain reduced public company reporting requirements for this prospectus and future filings with the
Securities and Exchange Commission.

We