Company: HURA
Filing Date: 2025-12-10
Form Type: 424B5
Source: 0001193125-25-313799
Chunk: 41

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-12-10
Form: 424B5
Chunk 41
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| • |     | contingent reimbursement obligations with respect to letters of credit issued or supported by our working capital 
 lenders for our account; and                                                                                      |

| • |     | obligations, liabilities, fees and expenses that we owe to our working capital lenders; |

unless the instrument creating or evidencing these obligations provides that these obligations are not senior or prior in right of payment to the subordinated debt securities. Notwithstanding the foregoing, “senior indebtedness” will not include:

| • |     | any of our obligations to our subsidiaries; |

| • |     | any liability for Federal, state, local or other taxes that we owe; |

| • |     | any accounts payable or other liability to trade creditors arising in the ordinary course of business, including 
 guarantees of these obligations or instruments evidencing such liabilities;                                      |

| • |     | any of our indebtedness, and any accrued and unpaid interest in respect of our indebtedness, that is subordinate 
 or junior in any respect to any other of our indebtedness or other obligations; or                               |

| • |     | the subordinated debt securities. |

There is no limitation on our ability to issue additional senior indebtedness. The senior debt securities constitute senior indebtedness under the subordinated indenture. Under the subordinated indenture, no payment may be made on the subordinated debt securities and no purchase, redemption or retirement of any subordinated debt securities may be made in the event:

| • |     | any senior indebtedness is not paid in full in cash when due; or |

| • |     | the maturity of any senior indebtedness is accelerated as a result of a default, unless the default has been       
 cured or waived and the acceleration has been rescinded or that senior indebtedness has been paid in full in cash. |

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We may, however, pay the subordinated debt securities without regard to the above restriction if the representatives of the holders of the applicable senior indebtedness approve the payment in writing to us and the trustee. The representatives of the holders of senior indebtedness may notify us and the trustee in writing (a “payment blockage notice”) of a default which can result in the acceleration of that senior indebtedness’ maturity without further notice, except such notice as may be required to effect such acceleration, or the expiration of any grace periods. In this event, we may not pay the subordinated debt securities for 179 days after receipt of that notice. The payment blockage period will end earlier if such payment blockage period is