Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 438

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 438
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 — |   |     |       |  3.53 | % |
| 5% Beneficial Owners                                               |     |              |           |     |     |        |       |   |     |                          |            |     |           |        |   |     |       |       |   |
| SCLX Stock Acquisition JV LLC                                      |     |              | 1,472,281 |  -9 |     |        | 17.31 | % |     |                          | 29,057,097 |     |           | 100.00 | % |     |       | 24.81 | % |
| Oramed Pharmaceuticals Inc.                                        |     |              |   833,473 | -10 |     |        |  8.94 | % |     |                          |          — |     |           |      — |   |     |       |  8.19 | % |
| Armistice Capital LLC                                              |     |              |   517,425 | -11 |     |        |  6.09 | % |     |                          |          — |     |           |      — |   |     |       |  5.54 | % |

| * | Less than 1%. |

| (1) | Unless otherwise indicated, the business address of each of the following individuals is 960 San Antonio Road, 
 Palo Alto, CA 94303.                                                                                           |

285

| (2) | Represents 316,955 shares subject to options exercisable within 60 days of December 5, 2025, 3,980 shares held                                                                                                                         
 directly and an aggregate of 4,453 shares held by family trusts for the benefit of Mr. Shah, his spouse and his children. Mr. Shah resigned as Chief Executive Officer and President effective as of August 17, 2025 and as a director 
 effective as of September 22, 2025.                                                                                                                                                                                                    |

| (3) | Represents 261,446 shares subject to options exercisable within 60 days of December 5, 2025, 9,147 shares held                                                                                                                   
 directly, an aggregate of 1,794 shares held through an entity owned by Dr. Ji, 161 shares held by Dr. Ji’s spouse and an aggregate of 8,350 shares held by family trusts for the benefit of Dr. Ji, his spouse and his children. |

| (4) | Represents 16