Company: XXII
Filing Date: 2025-08-15
Form Type: S-8
Source: 0001641172-25-024491
Chunk: 1

Company: 22nd Century Group, Inc.
Filing Date: 2025-08-15
Form: S-8
Chunk 1
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 GENERAL INSTRUCTION E</div>

This Registration Statement relates solely to the registration of additional securities of the same class as other securities for which a Registration Statement on this form relating to an employee benefit plan is effective. Pursuant to Instruction E of Form S-8, this Registration Statement incorporates by reference the contents of the Registration Statements previously filed with respect to the Plan on Form S-8 (Registration Nos. 333-284645, 333-280748, 333-274091 and 333-256616).

<div align='center'>PART II

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>

Item 3. Incorporation of Documents by Reference

The Registrant hereby incorporates by reference into this Registration Statement the following:

| (a) 
 (b) | Our                                                                                                                                                                                      
 Annual Report on Form 10-K for the fiscal year ended December 31, 2024 filed with the SEC                                                                                                
 on March 20, 2025, as amended on April 30, 2025;                                                                                                                                         
 Our                                                                                                                                                                                      
 definitive proxy statement filed with the SEC on June 10, 2025;                                                                                                                          |
|:----|:-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| (c) | Our                                                                                                                                                                                      
 Quarterly Reports on Form 10-Q filed with the SEC on May                                                                                                                                 
 13, 2025 and August                                                                                                                                                                      
 14, 2025;                                                                                                                                                                                |
| (d) | Our                                                                                                                                                                                      
 Current Reports on Form 8-K filed with the SEC on January 7, 2025, January 13, 2025, January 27, 2025, April 30, 2025, May 22, 2025, June 16, 2025, June 24, 2025 and July 15, 2025; and |
| (e) | The                                                                                                                                                                                      
 description of our common stock contained in or incorporated into our Registration Statement                                                                                             
 on Form 8-A, filed August 12, 2021, and any amendment or report updating that description.                                                                                               |

In addition, all documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a post-effective amendment which indicates that all securities offered have been sold or which deregisters all securities then remaining unsold (other than information deemed to have been “furnished” rather than “filed” in accordance with the Commission’s