Company: EDSA
Filing Date: 2025-09-09
Form Type: 424B5
Source: 0001171843-25-005799
Chunk: 3

Company: Edesa Biotech, Inc.
Filing Date: 2025-09-09
Form: 424B5
Chunk 3
---
 OF CERTAIN DOCUMENTS BY REFERENCE | S-26 |

|                                                             | Page |
| PROSPECTUS                                                  |      |
| ABOUT THIS PROSPECTUS                                       |    1 |
| CAUTIONARY NOTE ON FORWARD-LOOKING STATEMENTS               |    2 |
| PROSPECTUS SUMMARY                                          |    3 |
| RISK FACTORS                                                |    5 |
| USE OF PROCEEDS                                             |    5 |
| THE SECURITIES WE MAY OFFER                                 |    6 |
| DESCRIPTION OF CAPITAL SHARES                               |    7 |
| DESCRIPTION OF WARRANTS                                     |   12 |
| DESCRIPTION OF DEBT SECURITIES                              |   13 |
| DESCRIPTION OF SUBSCRIPTION RIGHTS                          |   18 |
| DESCRIPTION OF UNITS                                        |   19 |
| FORMS OF SECURITIES                                         |   20 |
| PLAN OF DISTRIBUTION                                        |   22 |
| CERTAIN U.S. AND CANADIAN FEDERAL INCOME TAX CONSIDERATIONS |   26 |
| LEGAL MATTERS                                               |   26 |
| EXPERTS                                                     |   26 |
| ADDITIONAL INFORMATION                                      |   26 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE           |   27 |

### ABOUT THIS PROSPECTUS SUPPLEMENT
This prospectus supplement and the accompanying base
prospectus are part of a registration statement on Form S-3 (File No. 333-288966) that we filed with the Securities and Exchange Commission
(the “SEC”) utilizing a “shelf” registration process. Each time we conduct an offering to sell securities under
the accompanying base prospectus we will provide a prospectus supplement that will contain specific information about the terms of that
offering, including the price, the amount of securities being offered and the plan of distribution. The shelf registration statement was
initially filed with the SEC on July 25, 2025, and was declared effective on September 9, 2025. This prospectus supplement describes the
specific details regarding this offering and may add, update or change information contained in the accompanying base prospectus. The
accompanying base prospectus provides general information about us and our securities, some of which, such as the section entitled “Plan of Distribution,” may not apply to this offering. This prospectus supplement and the accompanying base prospectus are an offer
to sell only the securities offered hereby, but only under circumstances and in jurisdictions