Company: MDXG
Filing Date: 2025-07-28
Form Type: S-8
Source: 0001376339-25-000082
Chunk: 0

Company: MIMEDX GROUP, INC.
Filing Date: 2025-07-28
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on July 28, 2025</div>

| Registration No. 333-______ |

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### WASHINGTON, D.C. 20549
<div align='center'>______________________________</div>

#### FORM S-8

### REGISTRATION STATEMENT UNDER

#### THE SECURITIES ACT OF 1933
<div align='center'>______________________________</div>

#### MiMedx Group, Inc.
<div align='center'>(Exact name of registrant as specified in its charter)</div>

| Florida                         |     | 26-2792552                          |
| (State or other jurisdiction of |     | -I.R.S. Employer Identification No. |
| incorporation or organization)  |     |                                     |

| 1775 West Oak Commons Ct., NE 
 Marietta, GA 30062            |

<div align='center'>(Address of Principal Executive Offices) (Zip Code)

MiMedx Group, Inc. 2016 Equity and Cash Incentive Plan

(Full title of the plan)

______________________________</div>

#### William F. Hulse IV

#### General Counsel and Secretary

#### 1775 West Oak Commons Ct., NE

#### Marietta, GA 30062
<div align='center'>(Name and address of agent for service)

(770) 651-9100

(Telephone number, including area code, of agent for service)

Copy to:</div>

#### Grant J. Levine, Esq.

#### Greenberg Traurig, P.A.

#### 401 East Las Olas Boulevard, Suite 2000

#### Fort Lauderdale, FL 33301
<div align='center'>(954) 765-0500</div>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer    ☒ |     | Accelerated filer    ☐         |
| Non-accelerated filer    ☐   |     | Smaller reporting company    ☐ |
|                              |     | Emerging growth company