Company: SPRB
Filing Date: 2025-06-06
Form Type: DEFA14A
Source: 0000950170-25-083045
Chunk: 27

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-06-06
Form: DEFA14A
Chunk 27
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 to the stockholders of the Corporation for their approval, and was duly adopted and approved in accordance with the provisions of Section 242 of the Delaware General Corporation Law.

<div align='center'>[Signature Page Follows]</div>

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1 The stockholders are requested to adopt an amendment approving the combination of any whole number of shares of the Corporation’s Common Stock at any ratio between 50:1 and 100:1. By approving Proposal No. 3, stockholders are approving each whole number between 50 and 100 proposed by the Corporation’s Board of Directors for the ratio. If the reverse stock split proposal is approved by stockholders, the Certificate of Amendment filed with the Secretary of State of the State of Delaware will include only that reverse stock split ratio determined by the Corporation’s Board of Directors to be in the best interests of the Corporation and its stockholders. The other amendments will be abandoned pursuant to Section 242(c) of the

General Corporation Law of the State of Delaware. The Corporation’s Board of Directors may also elect not to effect any reverse stock split, in which case all proposed alternate amendments will be abandoned.

IN WITNESS WHEREOF, Spruce Biosciences, Inc. has caused this Certificate of Amendment to be duly executed and acknowledged in its name and on behalf by an authorized officer of the date first set forth above.

|        |     | SPRUCE BIOSCIENCES, INC.     |
| By:    |     |                              |
| Name:  |     | Javier Szwarcberg, M.D., MPH |
| Title: |     | Chief Executive Officer      |

6. Signature Block

The date of “April 28, 2025” in the signature block on page 53 of the Proxy Statement shall be replaced with “June 6, 2025”

7. Proxy Card

The proxy card attached to the end of the Proxy Statement shall be amended and restated in its entirety as set forth below: