Company: SCLXW
Filing Date: 2025-05-15
Form Type: 424B3
Source: 0000950170-25-071914
Chunk: 3

Company: Scilex Holding Co
Filing Date: 2025-05-15
Form: 424B3
Chunk 3
---
 share information in the Prospectus and this prospectus supplement reflects the effect of the Reverse Stock Split. The Company’s historical financial statements included in the Prospectus and this prospectus supplement do not reflect the Reverse Stock Split.

This prospectus supplement updates and supplements the information in the Prospectus and is not complete without, and may not be delivered or utilized except in combination with, the Prospectus, including any amendments or supplements thereto. This prospectus supplement should be read in conjunction with the Prospectus and if there is any inconsistency between the information in the Prospectus and this prospectus supplement, you should rely on the information in this prospectus supplement.

See the section titled “Risk Factors” beginning on page 23 of the Prospectus as well as risks and uncertainties described under similar headings in any amendments or supplements to the Prospectus to read about factors you should consider before buying our securities.

<div align='center'>__________________</div>

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus supplement or the Prospectus. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus supplement is May 15, 2025.</div>

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON , D.C. 20549 FORM 10-Q

| ☒ | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 |

For the quarterly period ended: March 31, 2025

| ☐ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 |

For the transition period from to Commission File Number 001-39852 Scilex Holding Company (Exact Name of Registrant as Specified in Its Charter)

| Delaware                                                      |                         92-1062542 |
| (State or Other Jurisdiction ofIncorporation or Organization) | -I.R.S. EmployerIdentification No. |
| 960 San Antonio RoadPalo Alto, CA                             |                              94303 |
| (Address of Principal Executive Offices)                      |                          -Zip Code |

(650) 516-4310 (Registrant’s telephone number, including area code) Securities registered pursuant to Section 12(b) of the Act:

| Title of each class                                                                            |     | TradingSymbol(s)