Company: RVRC
Filing Date: 2025-08-13
Form Type: S-1/A
Source: 0001213900-25-075747
Chunk: 97

Company: Revium Rx.
Filing Date: 2025-08-13
Form: S-1/A
Chunk 97
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At ~20% market penetration, projected global
revenue could reach $632 million –1.26 billion annually, reflecting the premium pricing typical of targeted liposomal oncology
therapeutics and the severity of disease.

| Indication                       |     | Target              
 Use                 |     | U.S.        
 TAM         |     | Global      
 TAM         |     | Est.            
 Avg Price       
 (p/patient)     |     | Revenue                     
 Potential                   |
| Pancreatic Cancer (w/Gemzar/NAB) |     | Combination therpay |     | $0.8B–$1.6B |     | $0.6B–$1.3B |     | $12,950–$25,900 |     | High-value oncology segment |

We believe that our novel Liposomal-ARB formulation
of Candesartan may present a highly differentiated, complementary adjunct therapy to standard PDAC treatment. PDAC stands for Pancreatic
Ductal Adenocarcinoma, the most common and aggressive form of pancreatic cancer, accounting for over 90% of cases. Assumed pricing profile
aligns with other liposomal oncology drugs, and its use in a high-mortality, high-cost indication positions it as a commercially promising
candidate with potential $1billion dollar revenue upside globally.

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We believe that our novel nano-candesartan
combination therapy approach can play a pivotal role in this space, capturing a meaningful share of the expanding market by improving
treatment efficacy and delivering better outcomes for patients. [6]

References

| 1. | American Cancer Society. Pancreatic Cancer Survival Rates. https://www.cancer.org |

| 2. | GoodRx (2024). Gemzar and Abraxane Pricing Estimates. https://www.goodrx.com |

| 3. | Drugs.com (2024). Candesartan Cost Data. https://www.drugs.com |

| 4. | SEER Cancer Statistics (2023). Pancreatic                 
 Cancer Incidence – United States. https://seer.cancer.gov |

| 5. | GLOBOCAN 2022. Global Pancreatic Cancer      
 Incidence and Mortality. https://gco.iarc.fr |

| 6. | Solid Tumor Therapeutics Market Size                                                     
 by Cancer Type, by Drug Type,, Regions, Global Industry Analysis, Share, Growth, Trends, 
 and Forecast