Company: APM
Filing Date: 2025-10-14
Form Type: 424B5
Source: 0001213900-25-098635
Chunk: 27

Company: Aptorum Group Ltd
Filing Date: 2025-10-14
Form: 424B5
Chunk 27
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 Projects, is for SACT-1; patents
and applications for ALS-4 are licensed. We have, however, filed a number of provisional applications to establish earlier filing dates
for certain of our other ongoing research, the specifics of which are currently proprietary and confidential.

The U.S. patent system
permits the filing of provisional and non-provisional patent applications (i.e., a regular patent application). A non-provisional patent
application is examined by the USPTO and can mature into a patent once the USPTO determines that the claimed invention meets the standards
for patentability. On the other hand, a provisional patent application is not examined for patentability, and automatically expires 12 months
after its filing date. As a result, a provisional patent application cannot mature into a patent.

Provisional applications are
often used, among other things, to establish an earlier filing date for a subsequent non-provisional patent application. The term of individual
patents depends upon the legal term of the patents in the countries in which they are obtained.

The effective filing date of
a non-provisional patent application is used by the USPTO to determine what information is prior art when it considers the patentability
of a claimed invention. If certain requirements are satisfied, a non-provisional patent application can claim the benefit of the filing
date of an earlier filed provisional patent application. As a result, the filing date accorded by the provisional patent application may
supersede information that otherwise could preclude the patentability of an invention.

<div align='center'>S-15</div>

A provisional patent application is not eligible to become an issued patent unless, among other things, we file a non-provisional patent application within 12 months of the filing date of the provisional patent application. If we do not timely file a non-provisional patent application claiming priority to said provisional application, we may lose our priority date with respect to our provisional patent applications. Further, if any (self or by others) publication of the invention is made after such priority date, and if we do not file a non-provisional application claiming priority to said provisional application, our invention may become unpatentable. Moreover, we cannot predict whether such future patent applications will result in the issuance of patents that effectively protect any of our product candidates or will effectively prevent others from commercializing competitive products. We do not expect to incur material expenses in the prosecution of the provisional applications or other licensed patent applications. We