Company: CSTL
Filing Date: 2025-03-28
Form Type: PRE 14A
Source: 0001447362-25-000050
Chunk: 59

Company: CASTLE BIOSCIENCES INC
Filing Date: 2025-03-28
Form: PRE 14A
Chunk 59
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 •Achievement of certain reimbursement rates for DecisionDx-SCC |     | •Achieve specified validation study            
 •Achieve specified electronic ordering metrics 
 •Achieve specified reimbursement rates         |     | •Specified validation study achieved            
 •Specified electronic ordering metrics achieved 
 •Specified reimbursement rates achieved         |     |  25.0 | %                |     |  20.0 | %                | -2 |
|                       |     |                                                                |     |                                                |     |                                                 |     | 100.0 | %                |     | 128.8 | %                |    |

(1) The Compensation Committee used a sliding scale of revenue performance ranging from $283.0 million to $357.0 million to determine the actual weighting. The Compensation Committee used a sliding scale rather than a fixed threshold in order to better align the actual bonus payouts to the actual level of revenues, given the wide range of possible results. All points on this scale represent an increase in revenue performance from the prior year. The actual revenue for 2024 was $332.1 million. For illustration purpose, only the maximum, actual, target and minimum on the sliding scale of revenue is displayed.

#### 58Castle Biosciences 2025 Proxy Statement

#### Compensation Discussion and Analysis
|         |     |        |     | 2024 Revenue 
 ($ millions) |     |    | Growth over  
 2023 Revenue 
 of $220M     |     |     | Factor for   
 Pool Funding 
 (A)          |     |    | Target    
 Weighting 
 (B)       |     |       | Actual Weight for 
 Revenue Component 
 (A x B)           |
| Maximum |     |        |     |      $357.00 |     | 62 | %            |     | 150 | %            |     | 75 | %         |     | 112.5 | %                 |
|         |     | Actual |     |      $332.10 |     | 51 | %            |     | 145 | %            |     | 75 | %         |     | 108.8 | %                 |
| Target  |     |        |     |      $305.00 |     | 39 | %            |     | 100 | %            |     | 75 | %         |     |  75.0 | %                 |
| Minimum |     |        |     |      $283.00