Company: HCWB
Filing Date: 2025-04-07
Form Type: S-1
Source: 0001193125-25-073723
Chunk: 121

Company: HCW Biologics Inc.
Filing Date: 2025-04-07
Form: S-1
Chunk 121
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| 99.1        |     | Audit Committee Charter of the Registrant                                                                         |     |                           |      |     |          |           |     |             |      |     |             |            |     |           | X |
| 99.2        |     | Compensation Committee Charter of the Registrant                                                                  |     |                           |      |     |          |           |     |             |      |     |             |            |     |           | X |
| 97.1        |     | HCW Biologics Inc. Compensation Recovery Policy                                                                   |     |                           | 10-K |     |          | 011-40591 |     |             | 97.1 |     |             | 04/01/2024 |     |           |   |
| 107         |     | Filing Fees                                                                                                       |     |                           |      |     |          |           |     |             |      |     |             |            |     |           | X |

| * | Opinion of Clark Hill PLC to be filed by amendment. |

II-10

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this registration statement on Form S-1to be signed on its behalf by the undersigned, in the city of [●], State of Delaware, on April 4, 2025.

|        |     | HCW BIOLOGICS INC.                |
| By:    |     | /s/ Hing C. Wong                  |
| Name:  |     | Hing C. Wong                      |
| Title: |     | Founder & Chief Executive Officer |

POWER OF ATTORNEY Each person whose signature appears below constitutes and appoints [●], acting alone or together with another attorney-in-fact,as his or her true and lawful attorney-in-factand agent, with full power of substitution and re-substitution,for such person and in his or her name, place and stead, in any and all capacities, to sign any or all further amendments (including post-effective amendments) to this registration statement (and any additional registration statement related hereto permitted by Rule 462(b) promulgated under the Securities Act (and all further amendments, including post-effective amendments, thereto)), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the SEC, granting unto