Company: PSTV
Filing Date: 2025-08-12
Form Type: CORRESP
Source: 0001193125-25-179175
Chunk: 0

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-08-12
Form: CORRESP
Chunk 0
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August 12, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549

| Re: | Plus Therapeutics, Inc. |

Registration Statement on Form S-1filed on August 12, 2025 File No. 333-289526 Request for Acceleration of Effective Date Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended, Plus Therapeutics, Inc. hereby requests for acceleration of the effective date of the above-referenced registration statement, as amended, so that it becomes effective as of 5:30 p.m. Eastern Time on Thursday, August 14, 2025, or as soon thereafter as possible. [Signature Page to Follow]

| Very truly yours,              |     |                 |
| Plus Therapeutics, Inc.        |     |                 |
| By:                            |     | /s/ Andrew Sims |
| Name: Andrew Sims              |     |                 |
| Title: Chief Financial Officer |     |                 |

cc: Aaron M. Schleicher, Sullivan & Worcester LLP [Signature Page to Acceleration Request]