Company: PFSA
Filing Date: 2025-05-15
Form Type: 424B3
Source: 0001213900-25-044417
Chunk: 468

Company: Profusa, Inc.
Filing Date: 2025-05-15
Form: 424B3
Chunk 468
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 a cost reimbursable subcontract by the Henry Jackson Foundation (“HJF”). HJF partnered with Profusa to deploy and evaluate a continuous wireless biosensing technology, the Lumee Oxygen Platform, with the Austere environments Consortium for Enhanced Sepsis Outcomes (“ACESO”). ACESO’s collaborator, the Komfo Anokye Teaching Hospital (“KATH”) in Kumasi, Ghana. The scope of this Statement of Work (SOW) encompasses Profusa’s activities to support the clinical study to be performed in Ghana under Protocol NMRC.2022.0001 to understand subdermal oxygenation during sepsis by enabling detection of tissue oxygen levels and fluctuations in core and peripheral body sites. The total amount of the subcontract to Profusa in 2024 was less than $0.01million. The sepsis clinical study subcontract is a cost reimbursable program that pays for all direct costs plus fringe at the DCAA approved billing rate of 24.69% and G&A at the DCAA approved billing rate of 45.66%. This increase in revenue was the result of the Company beginning work on the subcontract to evaluate a continuous wireless biosensing technology, the Lumee Oxygen product, and to provide clinical data in a sepsis clinical study. Research and Development— Research and development expenses decreased by $0.4 million, or 21%, to $1.6 million during the year ended December31, 2024 from $2.0 million during the year ended December31, 2023. The decrease was driven primarily by the decrease in personnel costs of $0.3million as a result of reduction of personnel, the decrease in CRO costs of $0.2 million as a result of completion of several clinical studies, offset by an increase in regulatory fees of $0.1million.

268 General and Administrative— General and administrative expenses decreased by $1.1 million, or 27%, to $3.0 million during the year ended December31, 2024 from $4.1 million during the year ended December31, 2023. The decrease was driven primarily by the decrease in rent, office, and insurance expense of $0.1million as a result of terminating a month -to-monthlease during the year, the decrease in accounting and legal costs of $1.0 million as a result of the Company’s focus on the business combination transaction which results in accounting and legal costs associated with the transaction being deferred in other assets and capitalized versus exp