Company: RCUS
Filing Date: 2025-10-31
Form Type: 424B5
Source: 0001193125-25-260836
Chunk: 52

Company: Arcus Biosciences, Inc.
Filing Date: 2025-10-31
Form: 424B5
Chunk 52
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 be calculated, and the exchange period;                                                               |

| • |     | voting rights of the preferred stock; |

| • |     | preemptive rights, if any; |

| • |     | restrictions on transfer, sale or other assignment; |

| • |     | whether interests in the preferred stock will be represented by depositary shares; |

| • |     | a discussion of material United States federal income tax considerations applicable to the preferred stock; |

| • |     | the relative ranking and preferences of the preferred stock as to dividend rights and rights if we liquidate, 
 dissolve or wind up our affairs;                                                                              |

| • |     | any limitations on the issuance of any class or series of preferred stock ranking senior to or on a parity with      
 the series of preferred stock as to dividend rights and rights if we liquidate, dissolve or wind up our affairs; and |

| • |     | any other specific terms, preferences, rights or limitations of, or restrictions on, the preferred stock. |

Anti-takeover Effects of Provisions of our Certificate of Incorporation and Bylaws and Delaware Law Delaware Law We are governed by the provisions of Section 203 of the Delaware General Corporation Law regulating corporate takeovers. This section prevents some Delaware corporations from engaging, under some circumstances, in a business combination, which includes a merger or sale of at least 10% of the corporation’s assets with any interested stockholder, meaning a stockholder who, together with affiliates and associates, owns 11

or, within three years prior to the determination of interested stockholder status, did own 15% or more of the corporation’s outstanding voting stock, unless:

| • |     | the transaction is approved by the board of directors prior to the time that the interested stockholder became an 
 interested stockholder;                                                                                           |

| • |     | upon closing of the transaction that resulted in the stockholder becoming an interested stockholder, the                                                                                                                                     
 interested stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the transaction began, excluding for purposes of determining the voting stock outstanding those shares owned (i) by persons who are 
 directors and also officers and (ii) employee stock plans in which employee participants do not have the right to determine confidentially whether shares held subject to the plan will be tendered in a tender or exchange offer; or        |

| • |     | subsequent to such time that the stockholder became an interested stockholder the business combination is                                                                                                  
 approved by