Company: TYRA
Filing Date: 2025-05-08
Form Type: S-3
Source: 0001193125-25-116008
Chunk: 3

Company: Tyra Biosciences, Inc.
Filing Date: 2025-05-08
Form: S-3
Chunk 3
---
, or
directly to purchasers, or through a combination of these methods. If any underwriters, dealers or agents are involved in the sale of any of the securities, their names and any applicable purchase price, fee, commission or discount arrangement
between or among them will be set forth, or will be calculable from the information set forth, in the applicable prospectus supplement. See the sections of this prospectus entitled “About this Prospectus” and “Plan of
Distribution” for more information. No securities may be sold without delivery of this prospectus and the applicable prospectus supplement describing the method and terms of the offering of such securities.

INVESTING IN OUR SECURITIES INVOLVES RISKS. SEE THE “ RISK FACTORS” ON PAGE 7 OF THIS PROSPECTUS AND ANY SIMILAR SECTION CONTAINED IN THE APPLICABLE PROSPECTUS SUPPLEMENT CONCERNING FACTORS YOU SHOULD CONSIDER BEFORE INVESTING IN OUR SECURITIES.

Our common stock is
listed on the Nasdaq Global Select Market under the symbol “TYRA.” On May 6, 2025, the last reported sale price of our common stock on the Nasdaq Global Select Market was $10.00 per share.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

The date of this prospectus is , 2025.

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS                                 |     |  1 |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS  |     |  2 |
| WHERE YOU CAN FIND MORE INFORMATION; INCORPORATION BY 
 REFERENCE                                             |     |  3 |
| THE COMPANY                                           |     |  5 |
| RISK FACTORS                                          |     |  7 |
| USE OF PROCEEDS                                       |     |  8 |
| DIVIDEND POLICY                                       |     |  8 |
| DESCRIPTION OF CAPITAL STOCK                          |     |  9 |
| DESCRIPTION OF DEBT SECURITIES                        |     | 15 |
| DESCRIPTION OF WARRANTS                               |     | 23 |
| DESCRIPTION OF UNITS                                  |     | 25 |
| GLOBAL SECURITIES                                     |     | 26 |
| PLAN OF DISTRIBUTION                                  |     | 30 |
| LEGAL MATTERS                                         |