Company: PRME
Filing Date: 2025-02-28
Form Type: S-8
Source: 0001628280-25-008885
Chunk: 2

Company: Prime Medicine, Inc.
Filing Date: 2025-02-28
Form: S-8
Chunk 2
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 |     | /s/ Keith Gottesdiener                |
|                      |     | Keith Gottesdiener                    |
|                      |     | President and Chief Executive Officer |

### POWER OF ATTORNEY AND SIGNATURES
KNOW ALL BY THESE PRESENT, that each individual whose signature appears below hereby constitutes and appoints each of Keith Gottesdiener, Allan Reine, and Carman Alenson as such person’s true and lawful attorney-in-fact and agent with full power of substitution and resubstitution, for such person in such person’s name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto, and all documents in connection therewith, with the Securities and Exchange Commission granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that any said attorney-in-fact and agent, or any substitute or substitutes of any of them, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

| Name                   
 /s/ Keith Gottesdiener |     | Title                                           
 President, Chief Executive Officer and Director 
 (Principal Executive Officer)                   |     | Date              
 February 28, 2025 |
|:-----------------------|:----|:------------------------------------------------|:----|:------------------|
| Keith Gottesdiener     |     |                                                 |     |                   |
| /s/ Allan Reine        |     | Chief Financial Officer                         
 (Principal Financial Officer)                   |     | February 28, 2025 |
| Allan Reine            |     |                                                 |     |                   |
| /s/ Carman Alenson     |     | Chief Accounting Officer                        
 (Principal Accounting Officer)                  |     | February 28, 2025 |
| Carman Alenson         |     |                                                 |     |                   |
| /s/ Thomas Cahill      |     | Director                                        |     | February 28, 2025 |
| Thomas Cahill          |     |                                                 |     |                   |
|