Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 1

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 1
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 holder). We will not receive the proceeds from the
resale of the Private Warrant Shares hereunder; however, we will receive the proceeds from any exercise of the SPAC Warrants.

This
prospectus also relates to the offer and sale from time to time by:

(a) the selling stockholders named in this prospectus (including their
permitted transferees, donees, pledgees and other successors-in-interest) (collectively, the “Selling Stockholders”) of up to an aggregate of 1,594,207 shares
(the “Resale Shares”) of our Common Stock, consisting of:

(i) up to 41,082 shares of Common Stock (the
“Sponsor Shares”) held by Vickers Venture Fund VI Pte Ltd, Vickers Venture Fund VI (Plan) Pte Ltd and Suneel Kaji (collectively, the “Sponsors”), consisting of shares that were issued on November 9, 2022 upon conversion
of the same number of our former ordinary shares (initially acquired by the Sponsors prior to the initial public offering of units of Vickers Vantage Corp. I at a purchase price of $0.245 per ordinary share) in connection with the Domestication
(as defined below) and the Business Combination and shares that were also issued on November 9, 2022 upon the contribution of certain indebtedness by Vickers Venture Fund VI Pte Ltd and Vickers Venture Fund VI (Plan) Pte Ltd at a
contribution value of $350.00 per share, in connection with the Business Combination pursuant to a debt contribution agreement;

(ii) up to 1,513,040 shares of Common Stock (the “Merger Shares”) originally issued to Sorrento on November 10,
2022 in connection with the Business Combination at an equity consideration value of $350.00 per share, of which 1,458,263 shares were subsequently transferred to and are held by SCLX Stock Acquisition JV, our wholly owned subsidiary
(“SCLX JV”), and 54,777 shares are held by Sorrento in

abeyance for the benefit of certain holders of warrants to purchase shares of common stock of Sorrento; and

(iii) up to 40,085 Private Warrant Shares issuable upon the exercise of the Private Warrants at an exercise price of
$402.50 per whole share; and

(b) the selling warrantholders named in this prospectus (