Company: AZN
Filing Date: 2025-09-29
Form Type: 6-K
Source: 0001104659-25-094039
Chunk: 18

Company: ASTRAZENECA PLC
Filing Date: 2025-09-29
Form: 6-K
Chunk 18
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, AstraZeneca will enter into arrangements with the DI Depositary (as defined below) to enable Shareholders holding DTC Eligible London Listed Shares (the

#### “DTC Eligible Uncertificated Shareholders”
) to continue to hold, and settle transfers of, their interests in AstraZeneca Shares in CREST in the form of AstraZeneca DIs, each representing an entitlement to one underlying AstraZeneca Share. No AstraZeneca DIs will be created in respect of AstraZeneca Shares held outside the DTC system.

Whilst there will be technical differences with respect to the underlying settlement mechanics of trading AstraZeneca Shares in the UK by virtue of transacting through AstraZeneca DIs, in practice such Shareholders will continue to have substantially the same trading and settlement experience in the UK as they have today.

At the Effective Time, in accordance with Articles 149.1 and, 149.7 and 149.8 of the New Articles, the DTC Eligible London Listed Shares (including, for the avoidance of doubt, those held in the CSN Facility for the account of CSN Participants immediately prior to the Effective Time) will be transferred to the DTC Nominee. Book entry interests will be issued through DTC to the DTC participant account of CTCNA, acting in its capacity as custodian in respect of the DTC Eligible London Listed Shares represented by DTC book entry interests underlying the AstraZeneca DIs (the

#### “DI Custodian”
). The DI Custodian will hold those DTC book entry interests as custodian for Computershare Investor Services PLC, acting in its capacity as depositary for the AstraZeneca DIs (the

#### “DI Depositary”
). The DI Depositary will issue and apply AstraZeneca DIs representing such DTC Eligible London Listed Shares on a one-for-one basis through CREST to the CREST account in which each such DTC Eligible Uncertificated Shareholder previously held DTC Eligible London Listed Shares.

AstraZeneca DIs will be created and issued under the terms of the deed poll made by the DI Depositary (the

#### “DI Deed”
), which will govern the relationship between the DI Depositary and the holders of AstraZeneca DIs. The DI Deed is available on request from the DI Depositary from the date of this document. To request a copy of the DI Deed,