Company: LENZ
Filing Date: 2025-04-28
Form Type: DEF 14A
Source: 0001193125-25-100630
Chunk: 1

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-28
Form: DEF 14A
Chunk 1
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 submit your proxy or voting instructions via the Internet, telephone or mail as soon as possible.                                                                                                                                                                                                                                                                                                                                                                                                                                        |

| By order of the Board of Directors,   |
| Evert Schimmelpennink                 |
| President and Chief Executive Officer |
| Solana Beach, California              |
| April 28, 2025                        |

#### TABLE OF CONTENTSPageQUESTIONS AND ANSWERS ABOUT THE PROXY MATERIALS AND OUR ANNUAL MEETING1BOARD OF DIRECTORS AND CORPORATE GOVERNANCE7Composition of the Board7Nominees for Director7Continuing Directors8Director Independence9Board Leadership Structure10Role of Board in Risk Oversight Process10Board Committees10Attendance at Board and Stockholder Meetings13Executive Sessions ofNon-EmployeeDirectors13Compensation Committee Interlocks and Insider Participation13Considerations in Evaluating Director Nominees13Stockholder Recommendations and Nominations to our Board of Directors13Communications with the Board of Directors14Policy Prohibiting Hedging or Pledging of Securities14Corporate Governance Guidelines and Code of Business Conduct and Ethics14Director Compensation14PROPOSAL NO. 1: ELECTION OF CLASS III DIRECTORS AND CLASS I DIRECTORS18Nominees18Vote Required18Board Recommendation18PROPOSAL NO. 2: RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM19Fees Paid to the Independent Registered Public Accounting Firm19Auditor Independence20Audit Committee Policy onPre-Approvalof Audit and PermissibleNon-AuditServices of Independent Registered Public Accounting Firm20Vote Required20Board Recommendation20REPORT OF THE AUDIT COMMITTEE21EXECUTIVE OFFICERS22EXECUTIVE COMPENSATION23SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT41RELATED PERSON TRANSACTIONS44OTHER MATTERS48Stockholder Proposals or Director Nominations for 2025 Annual Meeting48Availability of Bylaws482024 Annual Report48

#### LENZ THERAPEUTICS, INC.

### PROXY STATEMENT

#### FOR 2025 ANNUAL MEETING OF STOCKHOLDERS
<div align='center'>**To be held at 10:00 a.m., Pacific Time, on Tuesday, June 10, 2025**</div>

This proxy statement and the enclosed form of proxy are being furnished in connection with the solicitation of proxies by our board of directors for use at our 2025 annual meeting of stockholders, and any postponements, adjournments or continu