Company: HURA
Filing Date: 2025-12-10
Form Type: 424B5
Source: 0001193125-25-313799
Chunk: 40

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-12-10
Form: 424B5
Chunk 40
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 the realizable value at the acceleration date of the money and government obligations in the defeasance trust could be less than the principal and interest then due on the debt securities, because the required deposit in the defeasance trust is based on scheduled cash flow rather than market value, which will vary depending on interest rates and other factors. Conversion and Exchange Rights The debt securities of any series may be convertible into or exchangeable for other securities of our company or another issuer or property or cash on the terms and subject to the conditions set forth in the applicable prospectus supplement. Governing Law The indentures and the debt securities will be governed by, and construed under, the laws of the State of New York without regard to conflicts of laws principles thereof. Regarding the Trustee We may from time to time maintain lines of credit, and have other customary banking relationships, with the trustee under the senior indenture or the trustee under the subordinated indenture. 11

The indentures and provisions of the Trust Indenture Act of 1939, which we refer to in this prospectus as the Trust Indenture Act, that are incorporated by reference therein, contain limitations on the rights of the trustee, should it become one of our creditors, to obtain payment of claims in certain cases or to realize on certain property received by it in respect of any such claim as security or otherwise. The trustee is permitted to engage in other transactions with us or any of our affiliates; provided, however, that if it acquires any conflicting interest (as defined under the Trust Indenture Act), it must eliminate such conflict or resign. Additional Terms Applicable to Subordinated Debt Securities The subordinated debt securities will be unsecured. The subordinated debt securities will be subordinate to the prior payment in full in cash of all senior indebtedness. The term “senior indebtedness” is defined as:

| • |     | any of our indebtedness, whether outstanding on the issue date of the subordinated debt securities of a series or 
 incurred later;                                                                                                   |

| • |     | accrued and unpaid interest, including interest accruing on or after the filing of any petition in bankruptcy or   
 for reorganization relating to us to the extent post-filing interest is allowed in such proceeding, in respect of: |

| • |     | our indebtedness for money borrowed; and |

| • |     | indebtedness evidenced by notes, debentures, bonds or other similar instruments for the payment of which we are 
 responsible or liable;                                                                                          |