Company: RPTX
Filing Date: 2025-12-03
Form Type: PREM14A
Source: 0001193125-25-306948
Chunk: 0

Company: Repare Therapeutics Inc.
Filing Date: 2025-12-03
Form: PREM14A
Chunk 0
---
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box:

| ☒ | Preliminary Proxy Statement |

| ☐ | Confidential, for Use of the Commission Only (as permitted by Rule 
 14a-6(e)(2))                                                       |

| ☐ | Definitive Proxy Statement |

| ☐ | Definitive Additional Materials |

| ☐ | Soliciting Material under §240.14a-12 |

Repare Therapeutics Inc. (Name of Registrant as Specified In Its Charter) Payment of Filing Fee (Check all boxes that apply):

| ☐ | No fee required. |

| ☐ | Fee paid previously with preliminary materials. |

| ☒ | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 
 14a-6(i)(1) and 0-11.                                                          |

PRELIMINARY MANAGEMENT INFORMATION CIRCULAR AND PROXY STATEMENT — SUBJECT TO COMPLETION, DATED DECEMBER 3, 2025.

REPARE THERAPEUTICS INC.

7171 Frederick-Banting, Building 2, Suite 270

St-Laurent,Québec, Canada H4S 1Z9

INVITATION TO SHAREHOLDERS

Dear
Shareholders,

You are cordially invited to attend a special meeting of the holders of Repare Therapeutics Inc. (the
“Company”) common shares (“Common Shares,” and the holders of such Common Shares, the “Shareholders”), which we will hold at 10:00 a.m. (Montreal time) on January 16, 2026 (the
“Special Meeting”). The Special Meeting will be held through a live webcast atwww.proxydocs.com/RPTX. In order to attend, you must register in advance atwww.proxydocs.com/RPTX prior to the
deadline of 10:00 a.m. (Montreal time) on January 16, 2026. Upon completing your registration, you will receive further instructions via email, including your unique links that will allow you access to the Special Meeting and will permit you to
submit questions. You will not be able to attend the Special Meeting in person