Company: IOBT
Filing Date: 2025-04-25
Form Type: DEF 14A
Source: 0000950170-25-058699
Chunk: 2

Company: IO Biotech, Inc.
Filing Date: 2025-04-25
Form: DEF 14A
Chunk 2
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| Principal Accountant Fees and Services                                                                                                                                                |     | 27 |
| Determination of Independence                                                                                                                                                         |     | 27 |
| Pre-Approval Policy                                                                                                                                                                   |     | 27 |
| Recommendation of Our Board of Directors and Audit Committee                                                                                                                          |     | 28 |
| Audit Committee Report                                                                                                                                                                |     | 28 |
| EXECUTIVE OFFICERS                                                                                                                                                                    |     | 29 |
| SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT                                                                                                                        |     | 30 |
| ADDITIONAL INFORMATION                                                                                                                                                                |     | 32 |
| Stockholder Proposals and Nominations                                                                                                                                                 |     | 32 |
| Other Matters                                                                                                                                                                         |     | 32 |

<div align='center'>IO BIOTECH, INC.

Ole Maaløes Vej 3

DK-2200 Copenhagen N

Denmark

ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD ON JUNE 5, 2025

PROXY STATEMENT

GENERAL INFORMATION</div>

This proxy statement is furnished to stockholders of IO Biotech, Inc. (“we,” “us,” “our” or the “Company”), a Delaware corporation, in connection with the solicitation of proxies by our board of directors for use at our 2025 annual meeting of stockholders to be held on June 5, 2025, and at any adjournment or postponement thereof (the “annual meeting”). The annual meeting will be held at 8:30 a.m. Eastern Time in a virtual meeting format. In order to attend the annual meeting, you must register atwww.proxydocs.com/IOBT. Upon completing your registration, you will receive further instructions via email, including a unique link that will allow you access to the annual meeting and to vote and submit questions during the annual meeting.

As permitted by the rules of the Securities and Exchange Commission (the “SEC”), we are making this proxy statement and our Annual Report on Form 10-K for the fiscal year ended December 31, 2024 available to our stockholders electronically via the Internet atwww.proxydocs.com/IOBT. You will be asked to enter the control number located on your proxy card or Notice of Internet Availability of Proxy Materials (“Internet Notice”). On or about April 25, 2025, we mailed to our stockholders the Internet Notice, containing instructions on how to access this proxy statement and vote online or by telephone. If