Company: INTS
Filing Date: 2025-04-24
Form Type: S-1/A
Source: 0001628280-25-019491
Chunk: 0

Company: INTENSITY THERAPEUTICS, INC.
Filing Date: 2025-04-24
Form: S-1/A
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on April 24, 2025.</div>

#### Registration No. 333-286683

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

#### Amendment No. 1 to

#### FORM S-1
<div align='center'>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933</div>

#### INTENSITY THERAPEUTICS, INC
#### .

<div align='center'>(Exact Name of Registrant as Specified in its Charter)</div>

| Delaware                        |     |                         2836 |     | 46-1488089         |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -Primary Standard Industrial 
   Classification Code Number |     | -I.R.S. Employer   
 Identification No. |

#### 1 Enterprise Drive, Suite 430

#### Shelton, CT 06484-4779
<div align='center'>(203) 221-7381

(Address, Including Zip Code, and Telephone Number, Including Area Code, of Registrant’s Principal Executive Offices)</div>

#### Lewis H. Bender

#### President, Chief Executive Officer and Chairman

#### 1 Enterprise Drive, Suite 430

#### Shelton, CT 06484-4779
<div align='center'>(203) 221-7381

(Name, Address, Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service)

Copies to:</div>

| Jeffrey P. Schultz, Esq.                            
 Ivan K. Blumenthal, Esq.                            
 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. 
 919 Third Avenue                                    
 New York, New York 10022                            
 212-935-3000                                        |     | Ron Ben-Bassat, Esq.                    
 Eric Victorson, Esq.                    
 Sullivan & Worcester LLP                
 1251 Avenue of the Americas, 19th Floor 
 New York, NY 10020                      
 (212) 660-3060                          |

Approximate date of commencement of proposed sale to the public: From time to time after the date this registration statement becomes effective.

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. x