Company: DNLI
Filing Date: 2025-04-17
Form Type: DEF 14A
Source: 0001714899-25-000087
Chunk: 48

Company: Denali Therapeutics Inc.
Filing Date: 2025-04-17
Form: DEF 14A
Chunk 48
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 to motivate and attract executives |     | Variable component of pay based on annual quantitative and qualitative performance assessment against objectives related to clinical testing, pipeline and functional goals                                                                                                                  |
| Equity Incentives      |     | To encourage executives and other employees to focus on long-term company performance; to promote retention; to reward outstanding company and individual performance     |     | Delivered in the form of stock options and RSUs, subject to multi-year vesting based on continued service. The value of these awards depends on the performance of our common stock price, which aligns employee and executive interests with those of our stockholders over the longer term |

Denali is committed to a strong performance orientation in our compensation program and effective corporate governance practices for a company at our development stage and industry. As such we routinely review our policies and program design. Some of our best practices in governance that we observe include:

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| What We Do |     |                                                  |
|            |     | •Align compensation with stockholder interests   |
|            |     | •Balance pay mix of fixed and variable pay       |
|            |     | •Align pay with performance                      |
|            |     | •Adopt robust anti-hedging and pledging policies |
|            |     | •Use a peer group to benchmark pay               |
|            |     | •Employ a clawback policy                        |
|            |     | •Retain a compensation consultant                |

| What We Don't Do |     |                                       |
|                  |     | •Guarantee bonuses                    |
|                  |     | •Provide excessive perquisites        |
|                  |     | •Provide excessive severance payments |
|                  |     | •Provide excise tax gross ups         |

Base Salary

Base salary is the only fixed component of our executive officers’ total cash compensation and provides competitive pay to attract and retain our executives. Annual salary decisions are made in recognition of competitive data as well as the skills and experience that each individual brings to the Company and the performance contributions each makes.

Base salary changes in 2024 varied by executive due to merit increases, as well as other factors considered, including tenure, experience and the role of the individual.

Annual base salaries for our NEOs were as follows:

|                           | Executive |   |    2023 |     |   |    2024 |     |     | Annual Increase |   |
|:--------------------------|:----------|:--|--------:|:----|: