Company: AGIO
Filing Date: 2025-04-25
Form Type: DEF 14A
Source: 0001193125-25-096719
Chunk: 10

Company: AGIOS PHARMACEUTICALS, INC.
Filing Date: 2025-04-25
Form: DEF 14A
Chunk 10
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 virtually or represented by proxy to hold the Annual Meeting. This is called a quorum. For purposes of determining whether a quorum exists, we count as present any shares that are voted over the internet, by telephone, by completing and submitting a proxy by mail, or that are represented virtually at the Annual Meeting. Further, for purposes of establishing a quorum, we will count as present shares that a stockholder holds even if the stockholder votes to abstain or only votes on one of the proposals. In addition, we will count as present shares that are “broker non-votes”.If a quorum is not present, we expect to adjourn the Annual Meeting until we obtain a quorum. The presence at the Annual Meeting, virtually or by proxy, of holders representing a majority of our outstanding common stock as of the record date, April 21, 2025, or approximately 28,957,600 shares, constitutes a quorum at the meeting and permits us to conduct the business of the meeting. 5

What vote is required to approve each matter and how are votes counted? Proposal 1 — Election of Directors The two nominees for director to receive the highest number of votes FOR election will be elected as directors. This is called a plurality. Proposal 1 is not considered a discretionary matter.Therefore, if your shares are held by your brokerage firm in “street name” and you do not timely provide voting instructions with respect to your shares, your brokerage firm cannot vote your shares on Proposal 1. Broker non-voteswill not be counted as votes FOR or WITHHELD from any nominee. As a result, such broker non-voteswill have no effect on the voting on Proposal 1. You may:

| • |     | vote FOR all nominees; |

| • |     | vote FOR a particular nominee or nominees and WITHHOLD your vote from the other nominees; or |

| • |     | WITHHOLD your vote from all nominees. |

Votes that are withheld will not be included in the vote tally for the election of directors and will have no effect on the voting on Proposal 1. Proposal 2 — Advisory Vote on the Compensation Paid to Named Executive Officers To approve Proposal 2, holders of a majority of the votes cast on the matter must vote FOR the proposal. Proposal 2 is not considered a discretionary matter.Shares which abstain and broker non-voteswill not be counted as votes in favor of, or with respect to, this proposal and will also not be counted