Company: TEM
Filing Date: 2025-02-25
Form Type: S-1
Source: 0001193125-25-034442
Chunk: 10

Company: Tempus AI, Inc.
Filing Date: 2025-02-25
Form: S-1
Chunk 10
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For additional information concerning the offering, see “Plan of Distribution” beginning on page 43.

4

RISK FACTORS

Investing in our Class A common stock involves a high degree of risk. You should carefully consider the risks and
uncertainties described under the heading “Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2024, which is incorporated by reference into this prospectus in its entirety, as well as any amendment or updates
to our risk factors reflected in subsequent filings with the SEC, including any prospectus supplement hereto or any related free writing prospectus, before deciding to invest in our Class A common stock. If any of the events or developments
described therein were to occur, our business, prospects, operating results and financial condition could suffer materially, the trading price of our Class A common stock could decline, and you could lose all or part of your investment. The
risks and uncertainties described therein are not the only ones we face. Additional risks and uncertainties not presently known to us or that we currently believe to be immaterial may also adversely affect our business.

5

USE OF PROCEEDS

We are filing the registration statement of which this prospectus forms a part to permit the selling stockholder to resell the
Shares, as described in the section below titled “Selling Stockholder”.

The selling stockholder will receive
all of the net proceeds from sales of the Shares sold pursuant to this prospectus. We will not receive any proceeds from the resale of any Shares offered by this prospectus by the selling stockholder.

We, and not the selling stockholder, will pay the costs, expenses and fees in connection with the registration of the Shares
covered by this prospectus, but the selling stockholder will pay all discounts, commissions or brokers’ fees or fees of similar securities industry professionals and transfer taxes, if any, attributable to sales of the Shares.

6

MANAGEMENT The following sets forth information, as of December 31, 2024, regarding our current executive officers and directors:

| Name                       |     | Age |    |     | Position                                                 |
| Executive Officers:        |     |     |    |     |                                                          |
| Eric Lefkofsky             |     |     | 55 |     | Chief Executive Officer, Founder and Director            |
| Ryan Fukushima             |     |     | 39 |     | Chief Operating Officer                                  |
| Erik Phelps                |     |