Company: SCLXW
Filing Date: 2025-12-16
Form Type: S-1
Source: 0001193125-25-319720
Chunk: 1

Company: Scilex Holding Co
Filing Date: 2025-12-16
Form: S-1
Chunk 1
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, an accelerated filer, a non-acceleratedfiler, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2of the Exchange Act.

| Large accelerated filer |     | ☐ |     | Accelerated filer         |     | ☐ |
| Non-accelerated filer   |     | ☒ |     | Smaller reporting company |     | ☒ |
|                         |     |   |     | Emerging growth company   |     | ☒ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☒ The Registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until the registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.

The information in this preliminary prospectus is not complete and may be changed. These securities may not be sold until the registration statement filed with the U.S. Securities and Exchange Commission is effective. This preliminary prospectus is not an offer to sell these securities and it is not soliciting an offer to buy these securities in any jurisdiction where the offer or sale is not permitted.

<div align='center'>PRELIMINARY — SUBJECT TO COMPLETION, DATED DECEMBER 15, 2025</div>

**PRELIMINARY PROSPECTUS**

<div align='center'>**SCILEX HOLDING COMPANY

Up to 500,000 Shares of Common Stock Issuable Upon the Exercise of Warrants

Up to 1,703,946 Shares of Common Stock**</div>

This prospectus relates to the issuance by us of up to an aggregate of 500,000 shares of our common stock, par value $0.0001 per share (“Common Stock”), issuable upon the exercise of warrants to purchase up to an aggregate of 500,000 shares of our Common Stock (the “Exchange Warrants”).