Company: PFSA
Filing Date: 2025-08-22
Form Type: S-1/A
Source: 0001213900-25-079829
Chunk: 0

Company: Profusa, Inc.
Filing Date: 2025-08-22
Form: S-1/A
Chunk 0
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As filed with the Securities and Exchange Commission on August 22, 2025. Registration No. 333-289461 UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549 ___________________________________ Amendment No. 2
FORM S-1
REGISTRATION STATEMENTUNDER
THE SECURITIES ACT OF 1933 ___________________________________ PROFUSA, INC. ( Exact name of registrant as specified in its charter ) ___________________________________

| Delaware                        |     |                         3841 |     | 26-4589529            |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -Primary Standard Industrial 
   Classification Code Number |     | -I.R.S. Employer      
 Identification Number |

626 Bancroft Way
Suite A
Berkeley, CA 94710
(925) 997-6925 (Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices) ___________________________________ Ben C. Hwang Chief Executive Officer 626 Bancroft Way
Suite A Berkeley, CA 94710 (925) 997-6925 (Name, address, including zip code, and telephone number, including area code, of agent for service) ___________________________________ Copies to: Ralph V. De Martino, Esq.
Marc Rivera, Esq.
ArentFox Schiff LLP
1717 K Street, NW
Washington, DC 20006
Phone: (202) 724-6847 ___________________________________ Approximate date of commencement of proposed sale to the public: As soon as practicable after this registration statement becomes effective. If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933 check the following box: ☒ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering