Company: CSTL
Filing Date: 2025-11-03
Form Type: S-8
Source: 0001628280-25-048270
Chunk: 3

Company: CASTLE BIOSCIENCES INC
Filing Date: 2025-11-03
Form: S-8
Chunk 3
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3.                  |
| 99.3           |     | Forms of Stock Option Grant Notice, Option Agreement and Notice of Exercise under the Castle Biosciences, Inc. 2022 Inducement Plan, incorporated by reference to Exhibit 99.3 of the Registrant’s Registration Statement on Form S-8 (File No. 333-270146), filed with the SEC on March 1, 2023.                            |
| 107*           |     | Filing Fee Table                                                                                                                                                                                                                                                                                                             |

__________________________________

* Filed herewith.

### SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Friendswood, State of Texas, on November 3, 2025.

| CASTLE BIOSCIENCES, INC. |     |                                       |
| By:                      |     | /s/ Derek J. Maetzold                 |
|                          |     | Derek J. Maetzold                     |
|                          |     | President and Chief Executive Officer |

### POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Derek J. Maetzold and Frank Stokes, and each of them, as his or her true and lawful attorneys-in-fact and agents, each with the full power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and