Company: AZN
Filing Date: 2025-06-26
Form Type: 11-K
Source: 0001683168-25-004771
Chunk: 10

Company: ASTRAZENECA PLC
Filing Date: 2025-06-26
Form: 11-K
Chunk 10
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3 measurements). The three levels of the fair value hierarchy
under FASB ASC 820 are described as follows:

| 10 |

<div align='center'>ASTRAZENECA SAVINGS AND SECURITY PLAN

Notes to Financial Statements

December 31, 2024 and 2023

_______________</div>

| 4. | Fair Value Measurements, continued: |

Inputs to the valuation methodology are unadjusted quoted prices for identical assets or liabilities in active markets that the Plan
has the ability to access.

Inputs to the valuation
methodology include:

| • | Quoted prices for similar assets or liabilities in active markets                                                |
| • | Quoted prices for identical or similar assets or liabilities in inactive markets                                 |
| • | Inputs other than quoted prices that are observable for the asset or liability                                   |
| • | Inputs that are derived principally from or corroborated by observable market data by correlation or other means |

If the asset or liability has a specified (contractual)
term, the level 2 input must be observable for substantially the full term of the asset or liability.

Inputs to the valuation methodology are unobservable and significant to the fair value measurement.

The
asset’s or liability’s fair value measurement level within the fair value hierarchy is based on the lowest level of any input
that is significant to the fair value measurement. Valuation techniques used need to maximize the use of relevant observable inputs and
minimize the use of unobservable inputs.

The
following is a description of the valuation methodologies used for assets measured at fair value:

Common stock:Funds are invested in the common stock of AstraZeneca PLC (“AZ Common Stock”). The fair value is a quoted price
in an active market.

Mutual funds:Valued at fair value of shares held by the Plan at year end. The fair value is a quoted price in an active market.

Commingled funds and Collective trusts:Valued at the net asset value (“NAV”) of shares held by the Plan at year end. The NAVs,
provided by external investment managers as a practical expedient, are based on quoted prices for the fund’s underlying securities
(some of which are marketable), estimates, appraisals, assumptions, and methods that are reviewed by management. This investment category
has no unfunded commitments and there are no redemption restrictions.

Money market funds:Valued at fair value of shares held by the Plan at year end. The fair value is a quoted price in an active market.

Private equity funds:Val