Company: CRNX
Filing Date: 2025-02-27
Form Type: S-8
Source: 0000950170-25-029087
Chunk: 3

Company: Crinetics Pharmaceuticals, Inc.
Filing Date: 2025-02-27
Form: S-8
Chunk 3
---
 | X             |
| 23.2          |     | Consent of BDO USA, P.C., independent registered public accounting firm                                                       |     |                           |     |         |     |            |             |     | X             |
| 24.1          |     | Power of Attorney (included in the signature page to this Registration Statement)                                             |     |                           |     |         |     |            |             |     | X             |
| 107           |     | Filing Fee Table                                                                                                              |     |                           |     |         |     |            |             |     | X             |

<div align='center'>SIGNATURES</div>

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on February 27, 2025.

| CRINETICS PHARMACEUTICALS, INC. |                                       |
| By:                             | /s/ R. Scott Struthers, Ph.D.         |
| Name:                           | R. Scott Struthers, Ph.D.             |
| Title:                          | President and Chief Executive Officer |

<div align='center'>POWER OF ATTORNEY</div>

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints R. Scott Struthers, Ph.D. and Marc J.S. Wilson, and each of them, as his or her true and lawful attorney-in-fact and agent with full power of substitution, for him or her in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his or her substitute, may lawfully do or cause to be done by virtue hereof.

Pursuant to the