Company: TELO
Filing Date: 2025-02-04
Form Type: 10-K
Source: 0001493152-25-004872
Chunk: 281

Company: Telomir Pharmaceuticals, Inc.
Filing Date: 2025-02-04
Form: 10-K
Item: Item 1
Chunk 281
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 regulatory mechanism beyond copper ion chelation.

These
findings suggest Telomir-1’s potential to preserve cellular integrity, combat oxidative damage, and regulate metal ion balance—critical
factors in aging-related diseases and viral infections. This breakthrough supports further clinical development to assess its full potential
in disease intervention.

Graphic 6: Effect of Telomir-1 on Oxidative Stress

Graphic 7: Effect of Telomir-1 on Copper Toxicity

11

Expanding
Telomir-1’s Therapeutic Potential

Building
on these results, Telomir is planning and advancing studies to expand the therapeutic potential of Telomir-1. Key ongoing initiatives
include:

    ●
    Wilson’s
    Disease Study: Investigating Telomir-1’s effects on copper regulation in preclinical models.

    ●
    Type
    2 Diabetes Studies: Following success in zebrafish studies, ongoing research in rat models aims to confirm Telomir-1’s
    efficacy in reversing key metabolic abnormalities

    ●
    Age-related
    Macular Degeneration: Assessing Telomir-1’s impact on retinal degeneration and Drusen formation caused by metal accumulation.

    ●
    Progeria:
    Examining Telomir-1’s impact on accelerated aging and telomere function.

    ●
    Cancer
    Research: Exploring anti-cancer applications using xenograft studies.

    ●
    Alzheimer’s
    Disease: Investigating Telomir-1 for its potential to address cognitive decline and neurodegeneration. 

    ●
    Metal
    Toxicity: Examining Telomir-1’s capacity to reduce harmful metal accumulation and associated cellular damage.

    ●
    DNA
    Methylation Analysis: Studying Telomir-1’s role in modulating DNA methylation to restore healthy gene expression patterns
    linked to aging and disease

    ●
    Viral Infections: Investigating Telomir-1’s
    effects on viral pathogenesis, including its potential to mitigate oxidative stress and immune dysfunction in infections such as
    avian influenza (bird flu).

Future
Plans and Milestones

Telomir-1
has demonstrated significant potential in reversing age-related and metabolic conditions while targeting underlying disease mechanisms.
As the company continues to refine the molecular understanding of Telomir-1, efforts are underway to identify the most impactful indication
for its initial IND application.

The