Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 4

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 4
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 MANAGEMENT                                                              |     |      | 229 |
| EXECUTIVE AND DIRECTOR COMPENSATION                                     |     |      | 241 |
| CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS                    |     |      | 267 |
| PRINCIPAL SECURITYHOLDERS                                               |     |      | 285 |
| MATERIAL U.S. FEDERAL INCOME TAX CONSEQUENCES                           |     |      | 287 |
| DESCRIPTION OF OUR SECURITIES                                           |     |      | 293 |
| LEGAL MATTERS                                                           |     |      | 311 |
| EXPERTS                                                                 |     |      | 311 |
| WHERE YOU CAN FIND MORE INFORMATION                                     |     |      | 311 |
| INDEX TO CONSOLIDATED FINANCIAL STATEMENTS                              |     |      | F-1 |

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You should rely only on the information we have provided in this prospectus, any applicable prospectus
supplement and any related free writing prospectus. We have not authorized anyone to provide you with information different from that contained in this prospectus, any applicable prospectus supplement or any related free writing prospectus. No
dealer, salesperson or other person is authorized to give any information or to represent anything not contained in this prospectus, any applicable prospectus supplement or any related free writing prospectus. You must not rely on any unauthorized
information or representation. This prospectus is an offer to sell only the securities offered hereby, but only under circumstances and in jurisdictions where it is lawful to do so. You should assume that the information in this prospectus, any
applicable prospectus supplement or any related free writing prospectus is accurate only as of the date on the front of the applicable document, regardless of the time of delivery of this prospectus or any sale of a security. Since the date of this
prospectus and the documents incorporated by reference into this prospectus, our business, financial condition, results of operations and prospects may have changed.

For Investors Outside the United States: We are offering the securities offered by this prospectus only in jurisdictions where offers and sales are
permitted. We have not done anything that would permit this offering or the possession or distribution of this prospectus in any jurisdiction where action for that purpose is required, other than in the United States. Persons outside the United
States who come into possession of this prospectus must inform themselves about, and observe any restrictions relating to, the offering of the securities offered by this prospectus and the