Company: RNLXY
Filing Date: 2025-07-25
Form Type: S-8 POS
Source: 0001213900-25-067774
Chunk: 0

Company: Renalytix plc
Filing Date: 2025-07-25
Form: S-8 POS
Chunk 0
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Registration No. 333-274732

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

POST-EFFECTIVE AMENDMENT NO. 1

TO

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

Renalytix plc

(Exact name of registrant as specified in
its charter)</div>

| England and Wales                              |     | Not applicable                      |
| (State or other jurisdiction of incorporation) |     | -I.R.S. Employer Identification No. |

| 2 Leman Street                                      
 London E1W 9US                                      
 United Kingdom                                      |
| (Address of principal executive offices) (Zip Code) |

| Renalytix AI plc 2020 Employee Share   
 Purchase Plan                          
 Renalytix AI plc 2020 Equity Incentive 
 Plan                                   |
| (Full title of the plan)               |

| Renalytix AI,                                                                   
 Inc.                                                                            
 1460 Broadway                                                                   
 New York, NY 10036                                                              
 Tel: +1 646 397 3970                                                            |
| (Name, address and telephone number, including area code, of agent for service) |
| Copies to:                                                                      |
| Mark E. Rosenstein                                                              |
| Derick S. Kauffman                                                              |
| Stevens & Lee, P.C.                                                             |
| 620 Freedom Business Center, Suite 200                                          |
| King of Prussia, PA 19406                                                       |
| (610) 205-6000                                                                  |

Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging
growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer ☐   | Accelerated filer ☐       | Non-accelerated filer ☒ |
| Smaller reporting company ☒ | Emerging growth company ☒ |                         |

If an emerging growth company, indicate by
check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
standards provided pursuant to Section 13(a) of the Exchange Act. ☐

This