Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 8

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 8
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 We have agreed
to pay the Placement Agent the Placement Agent fees as set forth in the table below, which assumes we sell all of the securities offered by this prospectus. See “Plan of Distribution” on page 69 of this prospectus for more information
regarding these arrangements.

Investing in our ADSs involves a high degree of risk. See “ Risk Factors” beginning on page 8 of this prospectus and in the other documents that are incorporated by reference herein before purchasing any of the securities offered by this prospectus. Neither the U.S. Securities and Exchange Commission, or SEC, nor any other regulatory body has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

|                                 |     | Per ADS and  
 Accompanying 
 Warrants     |     | Per Pre-Funded 
 Warrant and    
 Accompanying   
 Warrants       |     | Total |
|:--------------------------------|:----|:-------------|:----|:---------------|:----|:------|
| Public Offering Price           |     | $            |     | $              |     | $     |
| Placement Agent Fees(1)         |     | $            |     | $              |     | $     |
| Proceeds to the Company (before 
 expenses)(2)(3)                 |     | $            |     | $              |     | $     |

| (1) | For a description of the compensation to be received by the Placement Agent, see “Plan of 
 Distribution” starting on page 69 for more information.                                   |

| (2) | Because there is no minimum number of securities or amount of proceeds required as a condition to closing in                                                                                                                                        
 this offering, the actual public offering amount, Placement Agent fees, and proceeds to us, if any, are not presently determinable and may be substantially less than the total maximum offering amounts set forth above. For more information, see 
 “Plan of Distribution.”                                                                                                                                                                                                                             |

| (3) | The amount of offering proceeds to us presented in this table does not give effect to any exercise of the 
 Warrants or the Pre-Funded Warrants.                                                                      |

The delivery to purchasers of the securities against payment is expected to be made on or about , 2025, subject to satisfaction of customary closing conditions. Sole Placement Agent LAIDLAW & COMPANY (UK) LTD. the date of this prospectus is , 2025

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