Company: QXO-PB
Filing Date: 2025-05-29
Form Type: 424B7
Source: 0001104659-25-054254
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Company: QXO, Inc.
Filing Date: 2025-05-29
Form: 424B7
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TABLE OF CONTENTS

#### Filed Pursuant to Rule 424(b)(7)​

#### Registration No. 333-281084​

### PROSPECTUS SUPPLEMENT
**(To Prospectus dated July 29, 2024)**

#### 67,528,459 Shares of Common Stock
**This prospectus supplement relates to the resale by the selling stockholders identified in this prospectus supplement (the “selling stockholders”) of 67,528,459 shares of common stock, par value $0.00001 per share (“common stock”), of QXO, Inc. (“QXO” or the “Company”). We will not receive any proceeds from the sale of the shares offered by this prospectus supplement.

The selling stockholders may sell the shares on any national shares exchange or quotation service on which the shares may be listed or quoted at the time of sale, on the over-the-counter market, in one or more transactions otherwise than on these exchanges or systems, such as privately negotiated transactions, or using a combination of these methods, and at fixed prices, at prevailing market prices at the time of the sale, at varying prices determined at the time of sale, or at negotiated prices. See “Plan of Distribution” for more information about how the selling stockholders may sell or otherwise dispose of their shares hereunder.

The selling stockholders may sell any, all or none of the shares offered by this prospectus supplement and we do not know when or in what amounts the selling stockholders may sell their shares hereunder.

Our common stock is listed on the New York Stock Exchange (the “NYSE”) under the symbol “QXO.” On May 28, 2025, the last reported sale price of our common stock on the NYSE was $16.98 per share.

See “Risk Factors” beginning on page S-13of this prospectus supplement and in the documents incorporated by reference in this prospectus supplement to read about factors you should consider before buying our shares.

Neither the Securities and Exchange Commission (the “SEC”) nor any state securities commission has approved or disapproved of these shares or determined if this prospectus supplement or the accompanying prospectus is truthful or complete. Any representation to the contrary is a criminal offense.**

<div align='center'>Prospectus Supplement dated May 29, 2025.</div>

TABLE OF CONTENTS

TABLE OF CONTENTS Prospectus Supplement

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