Company: AZN
Filing Date: 2025-06-26
Form Type: 11-K
Source: 0001683168-25-004771
Chunk: 14

Company: ASTRAZENECA PLC
Filing Date: 2025-06-26
Form: 11-K
Chunk 14
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Plan invests in various investment securities. Investment securities are exposed to various risks such as interest rate, market, and
credit risks. Due to the level of risk associated with certain investment securities, it is at least reasonably possible that
changes in the values of investment securities will occur in the near term and that such changes could materially affect the amounts
reported in the statement of net assets available for benefits.

| 13 |

<div align='center'>ASTRAZENECA SAVINGS AND SECURITY PLAN

Notes to Financial Statements

December 31, 2024 and 2023

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| 9. | Plan Amendments: |

Plan
Amendment No. 1 was executed on August 4, 2022 and revised the Plan compensation definition for purposes of determining participants’
AZ Retirement Company Contributions as well as allowed for post severance loan repayments.

Plan
Amendment No. 2 was executed on August 28, 2023 and amended the Plan to reflect the transfer of excess assets from the AstraZeneca Defined
Benefit Pension Plan (“Pension Plan”) as a result to the Pension Plan termination effective March 31, 2022.

Plan Amendment
No. 3 was executed on December 19, 2023 to merge the Alexion 401(k) Plan with and into the Plan effective December 29, 2023. All accounts
under the Alexion 401(k) Plan were fully vested as of December 29, 2023 and those accounts and any attributable earnings, shall be fully
vested under the Plan following the merger.

| 10. | Reconciliation                        
 of Financial Statements to Form 5500: |

The following
is a reconciliation of net assets available for benefits per the financial statements to the Form 5500 as of December 31, 2024 and 2023:

|                                                                                                                              |     |   |          2024 |   |     |   |          2023 |   |
|:-----------------------------------------------------------------------------------------------------------------------------|:----|:--|--------------:|:--|:----|:--|--------------:|:--|
| Net assets available for benefits per the financial statements                                                               |     | $ | 8,653,551,567 |   |     | $ | 7,610,111,717 |   |
| Adjustment from contract value to fair value for fully-benefit responsive investment contracts held by the Stable Value Fund |     |   |    (9,549