Company: SCLXW
Filing Date: 2025-12-12
Form Type: 424B3
Source: 0001193125-25-317689
Chunk: 4

Company: Scilex Holding Co
Filing Date: 2025-12-12
Form: 424B3
Chunk 4
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center'>2</div>

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

|                         | SCILEX HOLDING COMPANY |                                     |
|                         | By:                    | /s/ Henry Ji                        |
|                         | Name:                  | Henry Ji                            |
| Date: December 12, 2025 | Title:                 | Chief Executive Officer & President |

<div align='center'>3</div>

Exhibit 10.1

<div align='center'>AMENDMENT TO

NON-RECOURSE LOAN AND SECURITIES PLEDGE AGREEMENT</div>

This Amendment to Non-Recourse Loan and Securities Pledge Agreement (this“Amendment”)is made and effective as of December 8, 2025 between The St. James Bank and Trust Company Ltd. and Scilex Holding Company.

WHEREAS:

the parties hereto are parties to a Non-Recourse Loan and Securities Pledge Agreement dated as of December 1, 2025 (the “Loan Agreement”) ; and

the parties desire to enter into this Amendment to amend certain terms of the Loan Agreement.

NOW THEREFORE,the parties hereto hereby agree as follows:

Definitions. All capitalized terms used herein and not otherwise defined herein shall have the respective meanings given to them in the Loan Agreement.

Amendment. Effective as of the date hereof:

the reference to “Fifty Million Dollars ($50,000,000)” in Section 2.l(a) of the Loan Agreement is hereby deleted and replaced with "One Hundred Million Dollars ($100,000,000)”; and

Section 2.2(a) of the Loan Agreement is hereby deleted in its entirety and replaced with:

“(a) As general and continuing security for the due, prompt and complete performance and satisfaction of the Obligations, with effect from the date hereof, the Borrower hereby mortgages, pledges, charges and grants to the Lender a security interest, as and by way of a fixed and specific mortgage, pledge, charge and security interest, to and in favour of the Lender, in an aggregate of 85,838,800 Listco Securities as referenced in Exhibit A, together with such other Listco Securities that become Pledged Securities hereunder. As a condition precedent to the advance of each Tranche hereunder, the Borrower agrees to procure Delivery to the Borrower Securities Account (