Company: RPTX
Filing Date: 2025-12-03
Form Type: PREM14A
Source: 0001193125-25-306948
Chunk: 107

Company: Repare Therapeutics Inc.
Filing Date: 2025-12-03
Form: PREM14A
Chunk 107
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2, Suite 270, St-Laurent, Québec, Canada.

Notice to United States Shareholders

The solicitation of proxies involves securities of an issuer located in Canada and is being effected and
disclosed in accordance with the corporate laws of Canada and securities laws of the provinces of Canada as well as in accordance with the Exchange Act.

The enforcement by Shareholders of civil liabilities under United States federal securities laws may be affected adversely because the Company
is existing under the QBCA. Shareholders may not be able to sue a foreign company or its officers or directors in a foreign court for violations of United States federal securities laws. It may be difficult to compel a foreign company and its
officers and directors to subject themselves to a judgment by a United States court.

Advice to Registered Shareholders — Voting and Revocation of Proxies

A Registered Shareholder is a Shareholder that holds Common Shares in its own name. A Registered Shareholder may
attend and vote at the Special Meeting. Alternatively, a Registered Shareholder may deposit a proxy that nominates a Person or entity to represent the Shareholder at the Special Meeting. If you are a Registered Shareholder and you intend to
participate and vote at the Special Meeting online, you do not need to complete the proxy. See “Attending and Participating in the Special Meeting” below.

The proxy accompanying this Circular and Proxy Statement nominates officers and/or directors of the Company to represent that Shareholder at
the Special Meeting. A Shareholder desiring to appoint a Person or entity, other than those management nominees named in the accompanying form of proxy, to represent such Shareholder at the Special Meeting may do so by following the instructions in “Appointment of a Third Party as Proxy” below.

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Voting of Proxies

The Common Shares represented by properly completed and executed proxies that are received in the manner prescribed above will be voted in
accordance with the instructions of the Shareholder, including on any ballot votes that may take place at the Special Meeting. If you have not specified how to vote on a particular matter, then your proxy holder can vote your Common Shares as he or
she sees fit. Where no choice is specified, the Common Shares represented by properly completed and executed proxies in favor of the management proxy nominees named in the printed portion of the enclosed proxy will be voted “FOR”
the Arrangement Resolution approving the Arrangement and “FOR” the Compensation Resolution, Liquidation Resolution and Liquidator Resolution.

The accompanying proxy also confers discretionary authority upon the