Company: ERAS
Filing Date: 2025-08-12
Form Type: S-3
Source: 0001193125-25-179038
Chunk: 0

Company: Erasca, Inc.
Filing Date: 2025-08-12
Form: S-3
Chunk 0
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As filed with the Securities and Exchange Commission on August 12, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 ERASCA, INC. (Exact Name of Registrant as Specified in Its Charter)

| Delaware                        |     | 3115 Merryfield Row, Suite 300  
 San Diego, California 92121     
 (858) 465-6511                  |     | 83-1217027         |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -Address of Principal Executive 
 Offices including Zip Code      |     | -I.R.S. Employer   
 Identification No. |

Jonathan E. Lim, M.D. Chairman and Chief Executive Officer Erasca, Inc. 3115 Merryfield Row, Suite 300 San Diego, California 92121 (858) 465-6511 (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies to:

| Matthew T. Bush                
 Cheston J. Larson              
 Latham & Watkins LLP           
 12670 High Bluff Drive San     
 Diego, CA 92130 (858) 523-5400 |     | David M. Chacko, M.D., Chief Financial Officer        
 and Chief Business Officer                            
 Ebun S. Garner, General Counsel                       
 Erasca, Inc. 3115                                     
 Merryfield Row, Suite 300 San Diego, California 92121 
 (858) 465-6511                                        |

APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:From time to time after the effective date of this registration statement. If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐ If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. ☒ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment