Company: TAK
Filing Date: 2025-06-25
Form Type: F-3ASR
Source: 0001395064-25-000097
Chunk: 48

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-25
Form: F-3ASR
Chunk 48
---
 in connection with the securities being registered, the Registrants will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933 and will be governed by the final adjudication of such issue.

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### EXHIBIT INDEX
| Exhibit Number 
 1.1            |     | Description                                                                                                                                                                                                                                                                                   
 Form of Underwriting Agreement for Senior Debt Securities issued by TPC (incorporated by reference to Exhibit 1.1 to the Registration Statement on Form F-3 of Takeda Pharmaceutical Company Limited filed with the Commission on June 26, 2024).                                             |
|:---------------|:----|:----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 1.2            |     | Form of Underwriting Agreement for Senior Debt Securities issued by TUSFI and guaranteed by TPC.                                                                                                                                                                                              |
| 4.1            |     | Indenture, dated as of July 9, 2020, between Takeda Pharmaceutical Company Limited and The Bank of New York Mellon, as Trustee (incorporated by reference to Exhibit 4.1 to the Current Report on Form 6-K furnished to the Commission by the Company on July 9, 2020).                       |
| 4.2            |     | Form of Indenture among Takeda Pharmaceutical Company Limited,as guarantor,Takeda U.S. Financing, Inc.,as issuer,The Bank of New York Mellon, as Trustee, The Bank of New York Mellon, London Branch, as London Paying Agent, The Bank of New York Mellon SA/SV, Dublin Branch, as Registrar. |
| 4.3            |     | Form of senior debt security issued under the Senior Indenture referred to in Exhibit 4.1*.                                                                                                                                                                                                   |
| 4.4            |     | Form of guaranteed senior debt security issued under the Senior Indenture referred to in Exhibit 4.2*.                                                                                                                                                                                        |
| 5.1            |     | Opinion of Sullivan & Cromwell LLP.                                                                                                                                                                                                                                                           |
| 5.2            |     | Opinion of Nishimura & Asahi (Gaikokuho Kyodo Jigyo).                                                                                                                                                                                                                                         |
| 22             |     | List of Issuers of Guaranteed Senior Debt Securities.