Company: SHPH
Filing Date: 2025-02-27
Form Type: 424B3
Source: 0001493152-25-008474
Chunk: 110

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-02-27
Form: 424B3
Chunk 110
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 2024 (issuance) |   |     |   | December 31, 2024 |   |
|:----------------------------|:----|:--|----------------------------:|:--|:----|:--|------------------:|:--|
| Risk-free interest rate     |     |   |                       4.15% 
                     - 4.27% |   |     |   |             4.16% |   |
| Expected term (years)       |     |   |                         1.0 
                       – 5.0 |   |     |   |              0.83 |   |
| Quoted VWAP                 |     | $ |                        1.88 |   |     | $ |              0.82 |   |
| Volatility                  |     |   |             62.28% - 97.05% |   |     |   |   57.50% - 97.14% |   |
| Discount rate               |     |   |                   40% - 60% |   |     |   |         40% - 60% |   |
| Probability assessments (1) |     |   |                   10% - 40% |   |     |   |         10% - 40% |   |
| Illiquidity discount        |     |   |                         -23 | % |     |   |               -26 | % |

| (1) |     | Probability assessments include the probabilities that subsequent successful                                                                   
 capital raises (in terms of amounts raised and timing) are not executed and the probability that the securities issuable under the convertible 
 bridge notes are not timely registered.                                                                                                        |

The following table summarizes the changes in the carrying value of the 2024 Convertible Bridge Notes:

Schedule of Fair Value Measurement using Significant Unobservable Inputs

| Fair Value Measurements Using Significant Unobservable Inputs (Level 3) 
 Balance - December 31, 2023                                             
 Issuance of 2024 Convertible Bridge Notes                               |     |   |        — 
  806,758 |   |
|:------------------------------------------------------------------------|:----|:--|---------:|:--|
| Gain on change in fair value                                            |     |   | (122,553 | ) |
| Balance - December 31, 2024                                             |     | $ |  684,205 |   |

| F-18 |

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