Company: LENZ
Filing Date: 2025-04-04
Form Type: S-3
Source: 0001628280-25-016818
Chunk: 0

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-04
Form: S-3
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on April 4, 2025</div>

#### Registration No. 333-

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

#### FORM S-3

### REGISTRATION STATEMENT

#### Under

#### The Securities Act of 1933

#### LENZ THERAPEUTICS, INC.
<div align='center'>(Exact name of Registrant as specified in its charter)</div>

| Delaware                        |     | 84-4867570            |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -I.R.S. Employer      
 Identification Number |

#### 201 Lomas Santa Fe Dr., Suite 300

#### Solana Beach, California 92075
<div align='center'>(858) 925-7000

(Address, including zip code, and telephone number, including area code, of Registrant’s principal executive offices)</div>

#### Evert Schimmelpennink

#### President and Chief Executive Officer

#### 201 Lomas Santa Fe Dr., Suite 300

#### Solana Beach, California 92075
<div align='center'>(858) 925-7000

(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>

<div align='center'>Copies to:</div>

#### Dan Koeppen

#### Jennifer Fang

#### Robert L. Wernli, Jr.

#### Ben Capps

#### Wilson Sonsini Goodrich & Rosati, P.C.

#### 12235 El Camino Real

#### San Diego, California 92130
<div align='center'>(858) 350-2300</div>

Approximate date of commencement of proposed sale to the public: From time to time after the effective date of this registration statement.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: o

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. x

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the