Company: SCLXW
Filing Date: 2025-09-29
Form Type: 424B3
Source: 0001193125-25-221020
Chunk: 47

Company: Scilex Holding Co
Filing Date: 2025-09-29
Form: 424B3
Chunk 47
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not acting in concert or as a group with respect to such obligations or the transactions contemplated hereby. The Sellers and Semnur acknowledge and each Buyer confirms that it has independently participated in the negotiation of the transaction
contemplated hereby with the advice of its own counsel and advisors. Each Buyer shall be entitled to independently protect and enforce its rights, including, without limitation, the rights arising out of this Agreement or out of any other agreements
entered into by the parties hereto in connection with the transactions contemplated by this Agreement, and it shall not be necessary for any other Buyer to be joined as an additional party in any proceeding for such purpose.

[Signature Page Follows]

19

IN WITNESS WHEREOF, each Seller, each Buyer and Semnur have caused their respective signature page to this Securities Purchase Agreement to be duly executed as of the date first written above.

| THE SELLERS:           |     |                                |
| SCILEX HOLDING COMPANY |     |                                |
| By:                    |     | /s/ Henry Ji                   |
|                        |     | Name: Henry Ji, Ph.D.          |
|                        |     | Title: Chief Executive Officer |

| SCILEX, INC. |     |                                |
| By:          |     | /s/ Henry Ji                   |
|              |     | Name: Henry Ji, Ph.D.          |
|              |     | Title: Chief Executive Officer |

[Signature Page to Securities Purchase Agreement]

IN WITNESS WHEREOF, each Seller, each Buyer and Semnur have caused their respective signature page to this Securities Purchase Agreement to be duly executed as of the date first written above.

| BUYER(S):        |     |                        |
| BICONOMY PTE.LTD |     |                        |
| By:              |     | /s/ Dmitriy Sheludko   |
|                  |     | Name: Dmitriy Sheludko 
 Title: CEO             |

IN WITNESS WHEREOF, each Seller, each Buyer and Semnur have caused their respective signature page to this Securities Purchase Agreement to be duly executed as of the date first written above.

| SEMNUR                                                                     |     |                                |
| SEMNUR PHARMACETUICALS INC., solely with respect to the Specified Sections |     |                                |
| By:                                                                        |     | /s/ Jaisim Shah                |
|                                                                            |     | Name: Jaisim Shah              |
|                                                                            |     | Title: