Company: LENZ
Filing Date: 2025-04-14
Form Type: 424B3
Source: 0001628280-25-017694
Chunk: 25

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-14
Form: 424B3
Chunk 25
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 a copy of the registration statement through the SEC’s website, as provided above.

### INCORPORATION BY REFERENCE
The SEC’s rules allow us to “incorporate by reference” information into this prospectus, which means that we can disclose important information to you by referring you to another document filed separately with the SEC. The information incorporated by reference is deemed to be part of this prospectus, and subsequent information that we file with the SEC will automatically update and supersede that information. Any statement contained in this prospectus or a previously filed document incorporated by reference will be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained in this prospectus or a subsequently filed document incorporated by reference modifies or replaces that statement.

This prospectus and any accompanying prospectus supplement incorporate by reference the documents set forth below that have previously been filed with the SEC:

• our Annual Report on Form 10-K for the year ended December 31, 2024, filed with the SEC on March 19, 2025 (our “Annual Report”);

• our Item 1.01 and 9.01 Current Report on Form 8-K filed with the SEC on April 4, 2025 ; and

• the description of our Common Stock contained in the Annual Report .

All reports and other documents we subsequently file pursuant to Section 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended, which we refer to as the “Exchange Act” in this prospectus, prior to the termination of this offering, including all such documents we may file with the SEC after the date of the initial registration statement and prior to the effectiveness of the registration statement, but excluding any information furnished to, rather than filed with, the SEC, will also be incorporated by reference into this prospectus and deemed to be part of this prospectus from the date of the filing of such reports and documents.

<div align='center'>17</div>

You may request a free copy of any of the documents incorporated by reference in this prospectus by writing or telephoning us at the following address:

<div align='center'>LENZ Therapeutics, Inc.

201 Lomas Santa Fe Dr., Suite 300

Solana Beach, California 92075

(858) 925-7000</div>

Exhibits to the filings will not be sent, however, unless those exhibits have specifically been incorporated by reference in this prospectus