Company: SCLXW
Filing Date: 2025-02-26
Form Type: PRER14A
Source: 0001193125-25-036730
Chunk: 0

Company: Scilex Holding Co
Filing Date: 2025-02-26
Form: PRER14A
Chunk 0
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PRELIMINARY COPY DATED FEBRUARY 26, 2025 — SUBJECT TO COMPLETION UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box:

| ☒ | Preliminary Proxy Statement |

| ☐ | Confidential, for Use of the Commission Only (as permitted by Rule 
 14a-6(e)(2))                                                       |

| ☐ | Definitive Proxy Statement |

| ☐ | Definitive Additional Materials |

| ☐ | Soliciting Material under §240.14a-12 |

SCILEX HOLDING COMPANY (Name of Registrant as Specified in Its Charter) N/A (Name of Person(s) Filing Proxy Statement, if other than the Registrant) Payment of Filing Fee (Check all boxes that apply):

| ☒ | No fee required. |

| ☐ | Fee paid previously with preliminary materials. |

| ☐ | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11. |

Explanatory Note

This Amendment No. 1 to Schedule 14A is being filed to revise the ratio of the reverse stock split contained in Proposal 1 of the
Company’s Preliminary Proxy Statement on Schedule 14A that was filed on February 14, 2025 (the “Original Preliminary Proxy”). No other changes were made to the Original Preliminary Proxy.

PRELIMINARY COPY DATED FEBRUARY 26, 2025 — SUBJECT TO COMPLETION SCILEX HOLDING COMPANY 960 San Antonio Road Palo Alto, CA 94303 NOTICE OF SPECIAL MEETING OF STOCKHOLDERS To Be Held at 9:00 a.m. Pacific Time on Wednesday, March 19, 2025 Dear Stockholders of Scilex Holding Company: We cordially invite you to attend a special meeting of stockholders (the “Special Meeting”) of Scilex Holding Company, a Delaware corporation (the “Company”, “Scilex”, “we”, “us” or “our”), which will be held virtually on Wednesday, March 19, 2025 at 9:00 a.m