Company: PFSA
Filing Date: 2025-08-22
Form Type: S-1/A
Source: 0001213900-25-079829
Chunk: 413

Company: Profusa, Inc.
Filing Date: 2025-08-22
Form: S-1/A
Chunk 413
---
 sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date; Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the shares of common stock being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. II-5

SIGNATURES Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this prospectus to be signed on its behalf by the undersigned, thereunto duly authorized.

| Date: August 22, 2025 |     | PROFUSA, INC. 
 By:           |     | /s/ Ben Hwang                               |
|:----------------------|:----|:--------------|:----|:--------------------------------------------|
|                       |     | Name:         |     | Ben Hwang                                   |
|                       |     | Title:        |     | Chairman of the Board and Chief Executive   |
|                       |     |               |     | -Principal Executive Officer                |
| Date: August 22, 2025 |     | By:           |     | /s/ Fred Knechtel                           |
|                       |     | Name:         |     | Fred Knechtel                               |
|                       |     | Title:        |     | Chief Financial Officer                     |
|                       |     |               |     | -Principal Financial and Accounting Officer |

Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed below by the following persons in the capacities