Company: MIRA
Filing Date: 2025-03-28
Form Type: 10-K
Source: 0001641172-25-001183
Chunk: 25

Company: MIRA PHARMACEUTICALS, INC.
Filing Date: 2025-03-28
Form: 10-K
Item: Item 1A
Chunk 25
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 products may not be considered cost-effective,
and government and third-party private health insurance coverage and reimbursement may not be available to patients for any of our future
products or sufficient to allow us to sell our products on a competitive and profitable basis. Our results of operations could be adversely
affected by ACA, changes to the ACA, and by other health care reforms that may be enacted or adopted in the future. In addition, increasing
emphasis on managed care in the U.S. will continue to put downward pressure on the pricing of pharmaceutical products. Cost-control initiatives
could decrease the price that we or any potential collaborators could receive for any of our future products and could adversely affect
our ability to generate revenue in the U.S. market and maintain profitability.

Unfavorable global economic
and geopolitical conditions could adversely affect our business, financial condition, stock price, and results of operations.

Our business
could be adversely affected by unstable economic and political conditions within the United States and foreign jurisdictions, including
as a result of an economic downturn and geopolitical events, such as changes in U.S. federal policy that affect the geopolitical landscape.
Changes to policy implemented by the U.S. Congress, the Trump administration or any new administration have impacted and may in the future
impact, among other things, the U.S. and global economy, international trade relations, unemployment, immigration, healthcare, taxation,
the U.S. regulatory environment, inflation and other areas. For example, during the prior Trump administration, increased tariffs were
implemented on goods imported into the U.S., particularly from China, Canada, and Mexico. On February 1, 2025, the U.S. imposed a 25%
tariff on imports from Canada and Mexico, which were subsequently suspended for a period of one month, and a 10% additional tariff on
imports from China. Historically, tariffs have led to increased trade and political tensions, between not only the U.S. and China, but
also between the U.S. and other countries in the international community. In response to tariffs, other countries have implemented retaliatory
tariffs on U.S. goods. Political tensions as a result of trade policies could reduce trade volume, investment, technological exchange
and other economic activities between major international economies, resulting in a material adverse effect on global economic conditions
and the stability of global financial markets. Any changes in political, trade, regulatory, and economic conditions, including U.S. trade
policies, could have a material adverse effect on our financial condition or results of operations