Company: SCLXW
Filing Date: 2025-01-17
Form Type: 424B3
Source: 0000950170-25-006777
Chunk: 3

Company: Scilex Holding Co
Filing Date: 2025-01-17
Form: 424B3
Chunk 3
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 utilized except in combination with, the Prospectus, including any amendments or supplements thereto. This prospectus supplement should be read in conjunction with the Prospectus and if there is any inconsistency between the information in the Prospectus and this prospectus supplement, you should rely on the information in this prospectus supplement.

See the section entitled “Risk Factors” beginning on page 14 of the Prospectus as well as risks and uncertainties described under similar headings in any amendments or supplements to the Prospectus to read about factors you should consider before buying our securities.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus supplement or the Prospectus. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus supplement is January 17, 2025

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 10-Q</div>

| ☒ | QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 |

<div align='center'>For the quarterly period ended: September 30, 2024</div>

| ☐ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 |

<div align='center'>For the transition period from to

Commission File Number 001-39852

Scilex Holding Company

(Exact Name of Registrant as Specified in Its Charter)</div>

| Delaware                                                      |                         92-1062542 |
| (State or Other Jurisdiction ofIncorporation or Organization) | -I.R.S. EmployerIdentification No. |
| 960 San Antonio RoadPalo Alto, CA                             |                              94303 |
| (Address of Principal Executive Offices)                      |                          -Zip Code |

<div align='center'>(650) 516-4310

(Registrant’s telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:</div>

| Title of each class                                                                           |     | TradingSymbol(s) |     | Name of exchange on which registered |
| Common Stock, par value $0.0001 per share                                                     |     | SCLX             |     | The Nasdaq Stock Market LLC          |
| Warrants to purchase one share of common