Company: CSTL
Filing Date: 2025-03-28
Form Type: PRE 14A
Source: 0001447362-25-000050
Chunk: 58

Company: CASTLE BIOSCIENCES INC
Filing Date: 2025-03-28
Form: PRE 14A
Chunk 58
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     | 500,042 |                  |        | 2.3 | % |
| Tobin W. Juvenal        |     | 482,300 |                  |     | 506,415 |                  |        | 5.0 | % |
| Kristen M. Oelschlager  |     | 482,300 |                  |     | 506,415 |                  |        | 5.0 | % |

#### Annual Performance-Based Cash Bonuses
Annual performance-based cash bonuses are designed to provide our NEOs with appropriate incentives to achieve defined annual performance goals. Payments under our annual cash bonus program are primarily based on the achievement of corporate performance goals pre-established by our Board. Goals are typically approved in the first quarter and are designed to incentivize focus and strong execution on the part of the leadership team. Actual performance against these performance goals funds the annual bonus plan pool and threshold levels of performance must be met for the pool to be funded.

Each of our NEOs participated in our 2024 annual cash bonus program. Executive officers who participate in this plan have a pre-established threshold, target and maximum cash bonus award opportunities, expressed as a percentage of their base salary. In setting the bonus opportunities for 2024, in 2024, the Compensation Committee approved adjustments to the 2023 bonus opportunities for our NEOs to better align with market practices, our performance and our compensation philosophy. The target bonus opportunity for Mr. Maetzold was increased from 95% to 100% of base salary. Additionally, the target bonus opportunities for Mr. Juvenal, Mr. Stokes and Ms. Oelschlager were each increased from 50% to 55% of base salary. These adjustments reflect the

#### Castle Biosciences 2025 Proxy Statement57

#### Compensation Discussion and Analysis
Committee’s ongoing review of competitive compensation positioning and are intended to ensure that our executive compensation program remains aligned with our performance and industry standards.

For 2024, our NEOs had the annual cash bonus opportunities set forth in the table below.

|                         |     | Payout Opportunities             
 (as a percentage of base salary) |      |           |     |       |        |     |       |         |
| Named Executive Officer |     |                                  |      | Threshold |     |       | Target |     |       | Maximum |
| Derek J. Maetzold       |     |                                  | 57.5 | %         |     | 100.0 | %