Company: SCLXW
Filing Date: 2025-12-16
Form Type: S-1
Source: 0001193125-25-319720
Chunk: 5

Company: Scilex Holding Co
Filing Date: 2025-12-16
Form: S-1
Chunk 5
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 align='center'>**The date of this prospectus is , 2025**</div>

#### TABLE OF CONTENTSPageABOUT THIS PROSPECTUS1CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS2CERTAIN DEFINED TERMS4PROSPECTUS SUMMARY9THE OFFERING17RISK FACTORS21MARKET AND INDUSTRY DATA112USE OF PROCEEDS113DETERMINATION OF OFFERING PRICE114DILUTION115PLAN OF DISTRIBUTION119DESCRIPTION OF THE EXCHANGE WARRANTS123DESCRIPTION OF THE SEPTEMBER 2025 WARRANTS125DESCRIPTION OF THE NOVEMBER 2025 WARRANTS127MARKET INFORMATION FOR SECURITIES AND DIVIDEND POLICY129MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS130BUSINESS165MANAGEMENT229EXECUTIVE AND DIRECTOR COMPENSATION241CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS267PRINCIPAL SECURITYHOLDERS285MATERIAL U.S. FEDERAL INCOME TAX CONSEQUENCES287DESCRIPTION OF OUR SECURITIES293LEGAL MATTERS311EXPERTS311WHERE YOU CAN FIND MORE INFORMATION311INDEX TO CONSOLIDATED FINANCIAL STATEMENTSF-1-i-
You should rely only on the information we have provided in this prospectus, any applicable prospectus supplement and any related free writing prospectus. We have not authorized anyone to provide you with information different from that contained in this prospectus, any applicable prospectus supplement or any related free writing prospectus. No dealer, salesperson or other person is authorized to give any information or to represent anything not contained in this prospectus, any applicable prospectus supplement or any related free writing prospectus. You must not rely on any unauthorized information or representation. This prospectus is an offer to sell only the securities offered hereby, but only under circumstances and in jurisdictions where it is lawful to do so. You should assume that the information in this prospectus, any applicable prospectus supplement or any related free writing prospectus is accurate only as of the date on the front of the applicable document, regardless of the time of delivery of this prospectus or any sale of a security. Since the date of this prospectus and the documents incorporated by reference into this prospectus, our business, financial condition, results of operations and prospects may have changed.

For Investors Outside the United States: We are offering the securities offered by this prospectus only in jurisdictions where offers and sales are permitted. We have not