Company: SXTPW
Filing Date: 2025-09-05
Form Type: 424B5
Source: 0001213900-25-085050
Chunk: 40

Company: 60 DEGREES PHARMACEUTICALS, INC.
Filing Date: 2025-09-05
Form: 424B5
Chunk 40
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 of the warrants sold in the July 2025 Offering, at a 
 weighted average exercise price of $5.82 per share;                                                                                   |

| ● | 28,437                                                                                                                             
 shares of common stock issuable upon exercise of outstanding options at a weighted average exercise price of $23.64 per share; and |

| ● | shares                                                                                     
 of common stock issuable upon the conversion of 76,480 shares of Series A Preferred Stock. |

Furthermore, we may choose to raise additional capital through the sale of equity or convertible debt securities due to market conditions or strategic considerations even if we believe we have sufficient funds for our current or future operating plans. New investors will experience further dilution if any of our outstanding options or warrants are exercised, new options are issued and exercised under our equity incentive plan or we issue additional shares of common stock, other equity securities or convertible debt securities in the future.

<div align='center'>S-24

PLAN OF DISTRIBUTION</div>

We entered into an At The
Market Sales Agreement with H.C. Wainwright & Co., LLC, as Agent, on September 5, 2025, under which we may offer and sell shares of
our common stock having an aggregate offering price of up to $1,397,532 from time to time through or to the Agent, as sales agent or principal.
Sales of our common stock, if any, under this prospectus supplement may be made in transactions that are deemed to be “at the market
offerings” as defined in Rule 415 under the Securities Act including sales made directly on or through the Nasdaq Capital Market,
the existing trading market for our common stock, sales made to or through a market maker other than on an exchange or otherwise, directly
to the Agent as principal, in negotiated transactions at market prices prevailing at the time of sale or at prices related to such prevailing
market prices, and/or in any other method permitted by law. We or the Agent may suspend the offering of common stock upon notice and subject
to other conditions.

Each time we wish to issue
and sell our common stock under the Sales Agreement, we will notify the Agent of the number or dollar value of shares to be issued, the
dates on which such sales are anticipated to be made, any minimum price below which sales may not be made and other sales parameters
as we deem appropriate. Once we have so instructed the Agent, unless such Agent declines to accept the terms of the notice, such Agent
has agreed to use