Company: SPRB
Filing Date: 2025-10-29
Form Type: S-3
Source: 0001193125-25-256668
Chunk: 29

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-10-29
Form: S-3
Chunk 29
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5  |
| 4.2     |     | Form of Pre-Funded Warrant to Purchase Common Stock.                                                                   | 8-K  | 001-39594                 |     4.1 | October 8, 2025  |
| 4.3     |     | Form of Common Stock Certificate.                                                                                      | S-1  | 333-248924                |     4.1 | October 5, 2020  |
| 5.1*    |     | Opinion of Cooley LLP.                                                                                                 |      |                           |         |                  |
| 10.1    |     | Form of Securities Purchase Agreement, dated October 7, 2025 by and among Spruce Biosciences, Inc. and the Purchasers. | 8-K  | 001-39594                 |    10.1 | October 8, 2025  |
| 23.1*   |     | Consent of independent registered public accounting firm.                                                              |      |                           |         |                  |
| 23.2    |     | Consent of Cooley LLP (included in Exhibit 5.1).                                                                       |      |                           |         |                  |
| 24.1    |     | Power of Attorney (included on signature page hereto).                                                                 |      |                           |         |                  |
| 107*    |     | Filing Fee Table.                                                                                                      |      |                           |         |                  |

* Filed herewith.

<div align='center'>II-2</div>

The undersigned registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

(i) To include any prospectus required by Section 10(a)(3) of the Securities Act;

(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent