Company: SION
Filing Date: 2025-02-07
Form Type: S-8
Source: 0001193125-25-022767
Chunk: 4

Company: Sionna Therapeutics, Inc.
Filing Date: 2025-02-07
Form: S-8
Chunk 4
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 available and the registrant will indemnify its directors and officers for any action or proceeding arising out of that person’s services as a director or officer brought on behalf of the registrant or in furtherance of its rights. Additionally, certain of the registrant’s directors or officers may have certain rights to indemnification, advancement of expenses or insurance provided by their affiliates or other third parties, which indemnification relates to and might apply to the same proceedings arising out of such director’s or officer’s services as a director referenced herein. Nonetheless, the registrant has agreed in the indemnification agreements that its obligations to those same directors or officers are primary and any obligation of such affiliates or other third parties to advance expenses or to provide indemnification for the expenses or liabilities incurred by those directors are secondary.

The registrant also maintains general liability insurance which covers certain liabilities of its directors and officers arising out of claims based on acts or omissions in their capacities as directors or officers, including liabilities under the Securities Act. Item 7. Exemption from Registration Claimed. Not applicable. Item 8. Exhibits. EXHIBIT INDEX

| Exhibit 
 No.     |     | Description                                                                                                                                                              |
| 4.1     |     | Form of Fifth Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.2 to the Registrant’s Registration                               
 Statement on Form S-1, as amended (File No. 333- 284352)).                                                                                                               |
| 4.2     |     | Form of Amended and Restated Bylaws (incorporated by reference to Exhibit 3.4 to the Registrant’s Registration Statement on Form S-1, as amended (File No. 333-284352)). |
| 4.3     |     | Third Amended and Restated Investors’ Rights Agreement, by and between the Registrant and certain of its stockholders, dated as of March 4,                              
 2024 (incorporated by reference to Exhibit 4.2 to the Registrant’s Registration Statement on Form S-1, as amended (File No. 333-284352)).                                |
| 5.1*    |     | Opinion of Goodwin Procter LLP.                                                                                                                                          |
| 23.1*   |     | Consent of Deloitte & Touche LLP, independent registered public accounting firm.                                                                                         |
| 23.2*   |     | Consent of Goodwin Procter LLP (included in