Company: NCEL
Filing Date: 2025-03-03
Form Type: F-4/A
Source: 0001213900-25-018981
Chunk: 567

Company: NewcelX Ltd.
Filing Date: 2025-03-03
Form: F-4/A
Chunk 567
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     | (6,674 | ) |     | (5,775 | ) |     | (6,990 | ) |     | (6,044 | ) |     | (3,195 | ) |     |    (1,215 | ) |
| Actuarial gains or losses attributed to defined benefit plans |     |    (15 | ) |     |      7 |   |     |    (22 | ) |     |     89 |   |     |    (10 | ) |     |         — |   |
| Net Loss                                                      |     | (6,688 | ) |     | (5,769 | ) |     | (7,011 | ) |     | (5,954 | ) |     | (3,205 | ) |     |    (1,215 | ) |

The Market Amyotrophic Lateral Sclerosis (ALS) Amyotrophic lateral sclerosis (ALS), formerly known as Lou Gehrig’s disease, is a neurological disorder that affects motor neurons, the nerve cells in the brain and spinal cord that control voluntary muscle movement and breathing. As motor neurons degenerate and die, they stop sending messages to the muscles, which causes the muscles to weaken, start to twitch (fasciculations), and waste away (atrophy). Eventually, in people with ALS, the brain loses its ability to initiate and control voluntary movements such as walking, talking, chewing and other functions, as well as breathing. ALS is progressive, meaning the symptoms get worse over time. The U.S. Food and Drug Administration has approved several drugs for ALS that may prolong survival, reduce the rate of decline, or help manage symptoms. However, there is currently no known treatment that stops or reverses the progression of ALS. Early symptoms include: •Muscle twitches in the arm, leg, shoulder, or tongue •Muscle cramps •Tight and stiff muscles (spasticity) •Muscle weakness affecting an arm, a leg, or the neck •Slurred and nasal speech •Difficulty chewing or swallowing As the disease progresses, muscle weakness and atrophy spread to other parts of your body. People with ALS may develop problems with: •Chewing food and swallowing (dysphagia) •Drooling (sialorrhea)

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Annex E-14

•Speaking or forming words (dysarthria) •Breathing (dyspnea) •Unintended crying, laughing, or