Company: INTS
Filing Date: 2025-06-27
Form Type: S-8
Source: 0001567264-25-000060
Chunk: 1

Company: INTENSITY THERAPEUTICS, INC.
Filing Date: 2025-06-27
Form: S-8
Chunk 1
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 growth company   |     | x |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. o

### EXPLANATORY NOTE
Intensity Therapeutics, Inc. (the “Registrant”) has prepared this Registration Statement on Form S-8 (the “Registration Statement”) in accordance with the requirements of Form S-8 under the Securities Act of 1933, as amended (the “Securities Act”), to register (i) 529,300 additional shares of common stock, $0.0001 par value per share (“Common Stock”), of the Registrant issuable pursuant to Registrant’s 2021 Stock Incentive Plan (the “2021 Plan”) and (ii) 500,000 shares of Common Stock issuable pursuant to the Registrant’s 2024 Employee Stock Purchase Plan (the “2024 ESPP”). The Registrant’s stockholders have previously approved the 2021 Plan and the 2024 ESPP, including the shares of Common Stock available for issuance pursuant thereto.

Pursuant to a Registration Statement on Form S-8 (File No. 333-274141) filed by the Registrant with the Securities and Exchange Commission (the “Commission”) on August 22, 2023 (the “Prior Registration Statement”), the Registrant previously registered an aggregate of 4,196,606 shares of Common Stock under the 2021 Plan.

In accordance with General Instruction E to Form S-8, the contents of the Prior Registration Statement are hereby incorporated by reference.

# PART II

### INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

## Item 3. Incorporation of Documents by Reference
The following documents filed by the Registrant with the Commission are hereby incorporated by reference into this Registration Statement:

(1) the Registrant’s Annual Report on Form 10-K for the fiscal year ended December 31, 2024, filed with the Commission on March 13, 2025 ;

(2) the Registrant’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, filed with the Commission on May 13, 2025 ;

(3) the Registrant’s Current Reports on Form 8-K filed with the Commission on April 25, 2025 , May 20, 2025 , June