Company: DNLI
Filing Date: 2025-02-27
Form Type: S-8
Source: 0001714899-25-000068
Chunk: 0

Company: Denali Therapeutics Inc.
Filing Date: 2025-02-27
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on February 27, 2025</div>

Registration No. 333-

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549
<div align='center'>________________________________________</div>

#### FORM S-8

### REGISTRATION STATEMENT

#### UNDER

#### THE SECURITIES ACT OF 1933
<div align='center'>________________________________________</div>

#### DENALI THERAPEUTICS INC.
<div align='center'>(Exact name of registrant as specified in its charter)</div>

| Delaware                                                     |     | 46-3872213         |
| (State or other jurisdiction of                              
 incorporation or organization)                               |     | -I.R.S. Employer   
 Identification No. |
| 161 Oyster Point Blvd.                                       
 South San Francisco, CA, 94080                               
 (650) 866-8547                                               |     |                    |
| (Address of principal executive offices, including zip code) |     |                    |

<div align='center'>________________________________________</div>

#### 2017 Equity Incentive Plan

#### 2017 Employee Stock Purchase Plan
<div align='center'>(Full title of the plan)

________________________________________</div>

#### Ryan J. Watts, Ph.D.

#### President and Chief Executive Officer

#### Denali Therapeutics Inc.

#### 161 Oyster Point Blvd.

#### South San Francisco, California 94080
<div align='center'>(650) 866-8547

(Name, address and telephone number, including area code, of agent for service)

________________________________________

Copies to:</div>

| Tony Jeffries                          
 Jennifer Knapp                         
 Wilson Sonsini Goodrich & Rosati, P.C. 
 650 Page Mill Road                     
 Palo Alto, California 94304            
 (650) 493-9300                         |     | Alexander O. Schuth, M.D.             
 Chief Operating and Financial Officer 
 Denali Therapeutics Inc.              
 161 Oyster Point Blvd.                
 South San Francisco, California 94080 
 (650) 866-8547                        |

<div align='center'>________________________________________</div>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of "large accelerated filer," "accelerated filer