Company: AGIO
Filing Date: 2025-06-18
Form Type: S-8
Source: 0001193125-25-142763
Chunk: 1

Company: AGIOS PHARMACEUTICALS, INC.
Filing Date: 2025-06-18
Form: S-8
Chunk 1
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SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on this 18 thday of June, 2025.

| AGIOS PHARMACEUTICALS, INC. |     |                         |
| By:                         |     | /s/ Brian Goff          |
|                             |     | Brian Goff              |
|                             |     | Chief Executive Officer |

POWER OF ATTORNEY AND SIGNATURES We, the undersigned officers and directors of Agios Pharmaceuticals, Inc., hereby severally constitute and appoint Brian Goff, Cecilia Jones and James Burns, and each of them singly, our true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the registration statement on Form S-8filed herewith and any and all subsequent amendments to said registration statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Agios Pharmaceuticals, Inc. to comply with the provisions of the Securities Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and all amendments thereto. Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

| Signature              
 /s/ Brian Goff         
 Brian Goff             
 /s/ Cecilia Jones      
 Cecilia Jones          |     | Title                                           
 Chief Executive Officer and Director (Principal 
 executive officer)                              
 Chief Financial Officer (Principal financial    
 officer)                                        |     | Date          
 June 18, 2025 
 June 18, 2025 |
|:-----------------------|:----|:------------------------------------------------|:----|:--------------|
| /s/ T.J. Washburn      
 T.J. Washburn          |     | Vice President, Controller (Principal