Company: NCNA
Filing Date: 2025-05-02
Form Type: F-1/A
Source: 0001193125-25-110310
Chunk: 29

Company: NuCana plc
Filing Date: 2025-05-02
Form: F-1/A
Chunk 29
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 statements and estimates. Forward-looking statements include, but are not limited to, statements about:

| • |     | the development of NUC-7738 and                                                                                                                            
 NUC-3373, as well as Acelarin, including statements regarding the expected initiation, timing, progress and availability of data from our clinical trials; |

| • |     | the potential attributes and benefit of our ProTides and their competitive positions; |

| • |     | our ability to successfully commercialize our ProTides, if approved; |

| • |     | our estimates regarding expenses, capital requirements and our need for additional financing; |

| • |     | our ability to acquire or in-license new product candidates; |

| • |     | potential collaborations; |

| • |     | the duration and strength of our patent portfolio; |

| • |     | our financial performance; |

| • |     | our use of proceeds from any offering made pursuant to this prospectus; |

| • |     | the length of time over which we expect our cash and cash equivalents to be sufficient; |

| • |     | our ability to complete the best efforts offering; |

| • |     | our ability to maintain the listing of our ADSs on The Nasdaq Capital Market; and |

| • |     | statements of belief and any statement of assumptions underlying any of the foregoing. |

These forward-looking statements are subject to known and unknown risks, uncertainties, assumptions and other factors that could cause our actual results of operations, financial condition, liquidity, performance, prospects, opportunities, achievements or industry results, as well as those of the markets we serve or intend to serve, to differ materially from those expressed in, or suggested by, these forward-looking statements. Factors that could cause actual results, financial condition, liquidity, performance, prospects, opportunities, achievements or industry results to differ materially include, but are not limited to, those discussed under “Risk Factors” in this prospectus and the documents incorporated by reference herein. Additional risks that we may currently deem immaterial or that are not presently known to us could also cause the forward-looking events discussed in this prospectus and the documents incorporated by reference herein not to occur. These forward-looking statements are based on assumptions regarding our present and future business strategies and the environment in which we expect to operate in the future. Forward-looking statements and estimates speak only at the date they were made, and we undertake no obligation to update or to review any forward-looking statement or estimate because of new information, future