Company: RGNX
Filing Date: 2025-03-13
Form Type: POS AM
Source: 0001193125-25-053998
Chunk: 24

Company: REGENXBIO Inc.
Filing Date: 2025-03-13
Form: POS AM
Chunk 24
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 we will be required to maintain a paying agent in each place of payment for the debt securities of a particular series. All moneys paid by us to a paying agent for payment on any debt security that remain unclaimed for a period of two years after the principal, premium or interest has become due and payable and was deposited with the paying agent will be paid to us, subject to any applicable abandoned property law. Global Securities The debt securities of any series may be represented, in whole or in part, by one or more global securities. Each global security will:

| • |     | be registered in the name of a depositary, or its nominee, that we will identify in a prospectus supplement; |

| • |     | be deposited with the trustee as custodian for the depositary; and |

| • |     | bear any required legends. |

No global security may be exchanged in whole or in part for debt securities registered in the name of any person other than the depositary or any nominee unless:

| • |     | the depositary has notified us that it is unwilling or unable to continue as depositary or has ceased to be 
 qualified to act as depositary;                                                                             |

| • |     | an event of default has occurred and is continuing with respect to the debt securities of the applicable series; 
 or                                                                                                               |

| • |     | any other circumstance described in a prospectus supplement has occurred permitting or requiring the issuance of 
 any such security.                                                                                               |

As long as the depositary, or its nominee, is the registered owner of a global security, the depositary or nominee will be considered the absolute owner of the debt securities represented by the global security for all purposes under the indenture. Participants in the depositary have no rights under the indenture with respect to the global securities held on their behalf by the depositary. Payments on a global security will be made to the depositary or its nominee as the holder of the global security. Some jurisdictions have laws that require that certain purchasers of securities take physical delivery of such securities in definitive form. These laws may impair the ability to transfer beneficial interests in a global security. 15

Ownership of beneficial interests in a global security are required to be shown on and effected through the book entry system maintained by the depositary (or its nominee), with respect to participants’ interests, or any participant, with respect to interests of persons held by participants on their behalf. Payments, transfers and exchanges relating to beneficial interests in a global security will be subject to policies