Company: ARWR
Filing Date: 2025-12-11
Form Type: S-3ASR
Source: 0001193125-25-314755
Chunk: 14

Company: ARROWHEAD PHARMACEUTICALS, INC.
Filing Date: 2025-12-11
Form: S-3ASR
Chunk 14
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 as they relate to any particular series of debt securities, other than the obligation to pay interest, if any, on and the principal of the debt securities of such series and certain other obligations, at any time by:

| • |     | depositing in trust with the trustee, under an irrevocable trust agreement, money or government obligations in an                      
 amount sufficient to pay principal of and interest, if any, on the debt securities of such series to their maturity or redemption; and |

| • |     | complying with other conditions, including delivery to the trustee of an opinion of counsel to the effect that                                                                                                                                         
 holders will not recognize income, gain or loss for federal income tax purposes as a result of our exercise of such right and will be subject to federal income tax on the same amount and in the same manner and at the same times as would have been 
 the case otherwise.                                                                                                                                                                                                                                    |

The indenture will also permit us to terminate all of our respective obligations under the indenture as they relate to any particular series of debt securities, including the obligations to pay interest, if any, on and the principal of the debt securities of such series and certain other obligations, at any time by:

| • |     | depositing in trust with the trustee, under an irrevocable trust agreement, money or government obligations in an                   
 amount sufficient to pay principal and interest, if any, on the debt securities of such series to their maturity or redemption; and |

| • |     | complying with other conditions, including delivery to the trustee of an opinion of counsel to the effect that                                                                                                                                       
 (A) we have received from, or there has been published by, the Internal Revenue Service a ruling, or (B) since the date such series of debt securities were originally issued, there has been a change in the applicable federal income tax          
 law, in either case to the effect that, and based thereon such opinion of counsel shall state that, holders will not recognize income, gain or loss for federal income tax purposes as a result of our exercise of such right and will be subject to 
 federal income tax on the same amount and in the same manner and at the same times as would have been the case otherwise.                                                                                                                            |

In addition, the indenture will permit us to terminate substantially all our respective obligations under the indenture as they relate to a particular series of debt securities by depositing with the trustee money or 10

government obligations sufficient to pay all principal and interest on such series at its maturity or redemption