Company: AZN
Filing Date: 2025-09-29
Form Type: 6-K
Source: 0001104659-25-094039
Chunk: 24

Company: ASTRAZENECA PLC
Filing Date: 2025-09-29
Form: 6-K
Chunk 24
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 who hold their AstraZeneca Shares in certificated form may find that holding and trading such shares directly involves US market practices and formalities that may be unfamiliar to such holders. In light of the foregoing, arrangements will be made for holders of DTC Eligible Certificated Shares who are resident in a CSN Permitted Jurisdiction (the

#### “CSN Eligible Certificated Shareholders”
) to have their DTC Eligible Certificated Shares held through the CSN Facility (such DTC Eligible Certificated Shares, the

#### “CSN Eligible Certificated Shares”
).

At the Effective Time, in accordance with Articles 149.2, 149.7 and 149.8 of the New Articles, DTC will credit book entry interests in respect of the CSN Eligible Certificated Shares to the account of the DI Custodian, which will hold those CSN Eligible Certificated Shares represented by DTC book entry interests as custodian for the DI Depositary. The DI Depositary will issue the AstraZeneca DIs representing such CSN Eligible Certificated Shares through CREST to the account of the CSN Nominee. The CSN Nominee will, in turn, hold those AstraZeneca DIs as nominee for the CSN Operator, with Computershare Investor Services PLC acting as trustee for such CSN Eligible Certificated Shareholders under the CSN Facility (details of which are included in the CSN Terms and Conditions annexed to this document). Each CSN Participant will receive a statement of entitlement from the CSN Nominee detailing their holding and explaining how they may deal in their AstraZeneca Shares through the CSN Facility, including details of ongoing services and details of the special dealing facility, where eligible.

CSN Participants will be able to lodge a trading instruction in respect of the underlying AstraZeneca Shares to which they are entitled by opening an account prior to dealing at www.computershare.com/dealing/uk, subject to any applicable due diligence requirements. For further guidance CSN Participants can contact Computershare by phone on 0370 707 1682 (from inside the UK) or +44 (0) 370 707 1682 (from outside the UK) between 8:30 a.m. to 5:30 p.m. (UK time), Monday to Friday (excluding public holidays in England and Wales) and provide their unique holder identification number detailed