Company: NCNA
Filing Date: 2025-07-16
Form Type: F-6 POS
Source: 0001193805-25-001028
Chunk: 3

Company: NuCana plc
Filing Date: 2025-07-16
Form: F-6 POS
Chunk 3
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 2025 and 
 incorporated herein by reference.                                                                                                     |

| (e) | Certificate under Rule 466. ___ None. |

| (f) | Powers of Attorney for certain officers and directors and the authorized representative of the Company. 
 ___ Set forth on the signature pages hereto.                                                            |

<div align='center'>II-1</div>

| Item 4. | UNDERTAKINGS |

| (a) | The Depositary undertakes to make available at the principal office of the Depositary in the United States,                                 
 for inspection by holders of ADSs, any reports and communications received from the issuer of the deposited securities which are both       
 (1) received by the Depositary as the holder of the deposited securities, and (2) made generally available to the holders of the underlying 
 securities by the issuer.                                                                                                                   |

| (b) | If the amount of fees charged is not disclosed in the prospectus, the Depositary undertakes to prepare                                 
 a separate document stating the amount of any fee charged and describing the service for which it is charged and to deliver promptly a 
 copy of such fee schedule without charge to anyone upon request. The Depositary undertakes to notify each registered holder of an ADS  
 thirty (30) days before any change in the fee schedule.                                                                                |

<div align='center'>II-2</div>

Pursuant to the requirements
of the Securities Act of 1933, as amended, Citibank, N.A., acting solely on behalf of the legal entity created by the Amended and Restated
Deposit Agreement, by and among NuCana plc, Citibank, N.A., as depositary, and all Holders and Beneficial Owners from time to time of
American Depositary Shares to be issued thereunder, certifies that it has reasonable grounds to believe that all the requirements for
filing on Form F-6 are met and has duly caused this Post-Effective Amendment No. 1 to Registration Statement on Form F-6 to be signed
on its behalf by the undersigned, thereunto duly authorized, in the City of New York, State of New York, on the 16th day of July, 2025.

| Legal entity created by the Amended and Restated Deposit Agreement under which the American Depositary Shares registered hereunder are to be issued, each American Depositary Share representing the right to receive five thousand (5,000) ordinary shares of NuCana plc. |                          |