Company: GANX
Filing Date: 2025-11-07
Form Type: S-3/A
Source: 0001104659-25-108472
Chunk: 3

Company: Gain Therapeutics, Inc.
Filing Date: 2025-11-07
Form: S-3/A
Chunk 3
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 supplement, together with additional information described under the headings “Additional Information” and “Incorporation of Certain Information by Reference” carefully before you invest. This prospectus may not be used to sell securities unless accompanied by a prospectus supplement.

We may sell these securities directly to our stockholders or to other purchasers or through agents on our behalf or through underwriters or dealers as designated from time to time, on a continuous or delayed basis. For additional information on the methods of sale, you should refer to the section titled “Plan of Distribution” in this prospectus. If any agents or underwriters are involved in the sale of any of these securities, the applicable prospectus supplement will provide the names of the agents or underwriters and any applicable fees, commissions, discounts, or over-allotment options will be set forth in a supplement to this prospectus. The price to the public of such securities and the net proceeds we expect to receive from such sale will also be set forth in a supplement to this prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.**

#### The date of this prospectus is       , 2025.
TABLE OF CONTENTS

TABLE OF CONTENTS

| ​ | ABOUT THIS PROSPECTUS                                | ​ | ​ | ​ | ​ |  1 | ​ | ​ |
| ​ | PROSPECTUS SUMMARY                                   | ​ | ​ | ​ | ​ |  2 | ​ | ​ |
| ​ | RISK FACTORS                                         | ​ | ​ | ​ | ​ |  5 | ​ | ​ |
| ​ | CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS | ​ | ​ | ​ | ​ |  6 | ​ | ​ |
| ​ | USE OF PROCEEDS                                      | ​ | ​ | ​ | ​ |  8 | ​ | ​ |
| ​ | THE SECURITIES WE MAY OFFER                          | ​ | ​ | ​ | ​ |  9 | ​ | ​ |
| ​ | DESCRIPTION OF CAPITAL STOCK                         | ​ | ​ | ​ | ​ | 10 | ​ | ​ |
| ​ | DESCRIPTION OF WARRANTS                              | ​ | ​ | ​ | ​ | 14 | ​ | ​ |
| ​ | DESCRIPTION OF DEBT SECURITIES                       | ​ | ​ | ​