Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 92

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 92
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 be subordinated in right of payment to the prior payment in full of all of
Comerica’s senior indebtedness, which term includes senior debt securities, as described below under ‘‘—Subordination.’’ In certain events of insolvency, the subordinated debt securities will also be subordinated
to certain other financial obligations, as described below under ‘‘—Subordination.’’

Because Comerica is a holding
company, its rights and the rights of its creditors, including holders of debt securities, and shareholders to participate in any distribution of assets of any subsidiary upon the subsidiary’s

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liquidation or reorganization or otherwise would be subject to the prior claims of the subsidiary’s creditors, except to the extent that Comerica is a creditor of the subsidiary. The right of Comerica’s creditors, including holders of debt securities, to participate in the distribution of stock owned by Comerica in some of its subsidiaries, including its banking subsidiaries, may also be subject to approval by bank regulatory authorities having jurisdiction over these subsidiaries. Each prospectus supplement will describe the following terms of the offered debt securities:

| • |     | the title of the series; |

| • |     | any limit on the aggregate principal amount; |

| • |     | the principal payment dates; |

| • |     | the interest rates, if any, which rate may be zero if the debt securities are issued at a discount from the                                                             
 principal amount payable at maturity, or the method by which the interest rates will be determined, including, if applicable, any remarketing option or similar method; |

| • |     | the date or dates from which interest, if any, will accrue or the method by which the date or dates will be 
 determined;                                                                                                 |

| • |     | the interest payment dates and regular record dates; |

| • |     | the place or places where the principal of, any premium or interest on any debt securities will be payable, where                                                
 any of debt securities may be surrendered for registration of transfer or exchange, and where any debt securities may be surrendered for conversion or exchange; |

| • |     | whether any of the debt securities are to be redeemable at Comerica’s option and, if so, the date or dates                                                          
 on which, the period or periods within which, the price or prices at which and the other terms and conditions upon which they may be redeemed, in whole or in part; |

| • |     | whether Comerica will be