Company: PFSA
Filing Date: 2025-10-29
Form Type: 424B3
Source: 0001213900-25-103174
Chunk: 343

Company: Profusa, Inc.
Filing Date: 2025-10-29
Form: 424B3
Chunk 343
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 segment expenses                                                          |     |                    |  1,003 |   |     |   |  1,001 |   |
| Loss from operations                                                            |     |                    | (1,003 | ) |     |   |   (976 | ) |
| Other income (expense)                                                          |     |                    |        |   |     |   |        |   |
| Loss on change in the fair value of related party Tasly convertible debt        |     |                    |    (57 | ) |     |   |    (15 | ) |
| Interest expense                                                                |     |                    | (1,289 | ) |     |   | (1,081 | ) |
| Other income                                                                    |     |                    |      1 |   |     |   |      1 |   |
| Total other expense, net                                                        |     |                    | (1,345 | ) |     |   | (1,095 | ) |
| Net loss and comprehensive loss                                                 |     | $                  | (2,348 | ) |     | $ | (2,071 | ) |

| (1) | Other expenses includes small balances of research materials 
 and supplies along with insurance costs.                     |

<div align='center'>F-51

PROFUSA, INC. AND SUBSIDIARY
NOTES TO THE CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
(UNAUDITED)</div>

Note 13 — Segments (cont.)

|                                                                                 |     | Six Months Ended 
 June 30,         |   2025 |   |     |   |   2024 |   |
|:--------------------------------------------------------------------------------|:----|:-----------------|-------:|:--|:----|:--|-------:|:--|
| Government grant revenuet                                                       |     | $                |      — |   |     | $ |     25 |   |
| Operating expenses:                                                             |     |                  |        |   |     |   |        |   |
| Research personnel compensation costs, including stock-based compensation       |     |                  |    658 |   |     |   |    818 |   |
| CRO and regulatory costs                                                        |     |                  |      — |   |     |   |     15 |   |
| Administrative personnel compensation costs, including stock-based compensation |     |                  |    736 |   |     |   |    712 |   |
| Rent and office costs