Company: CRNX
Filing Date: 2025-04-23
Form Type: DEF 14A
Source: 0000950170-25-057452
Chunk: 2

Company: Crinetics Pharmaceuticals, Inc.
Filing Date: 2025-04-23
Form: DEF 14A
Chunk 2
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 proxy materials be mailed to you, and you have received those materials, then you may vote via the Internet, by telephone or by mailing a completed proxy card. For specific voting instructions, please refer to the information provided in the accompanying Proxy Statement and in the Notice of Internet Availability of Proxy Materials. All stockholders are cordially invited to attend the annual meeting. We appreciate your continued support of the company.

| By Order of the Board of Directors,             |
| /s/ R. Scott Struthers, Ph.D.                   |
| R. Scott Struthers, Ph.D.                       |
| President, Chief Executive Officer and Director |

San Diego, California April 23, 2025 Your vote is important. Please vote your shares whether or not you plan to attend the annual meeting.

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TABLE OF CONTENTS

|                                                                                        |     | Page |
| GENERAL INFORMATION ABOUT THE ANNUAL MEETING AND VOTING                                |     |    1 |
| PROPOSAL 1: ELECTION OF DIRECTORS                                                      |     |    8 |
| PROPOSAL 2: RATIFICATION OF SELECTION OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM |     |   21 |
| PROPOSAL 3: APPROVAL OF THE COMPENSATION OF THE NAMED EXECUTIVE OFFICERS               |     |   23 |
| SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT                         |     |   24 |
| COMPENSATION DISCUSSION AND ANALYSIS                                                   |     |   28 |
| CERTAIN RELATIONSHIPS AND RELATED PERSON TRANSACTIONS                                  |     |   60 |
| STOCKHOLDER PROPOSALS                                                                  |     |   62 |
| ANNUAL REPORT                                                                          |     |   63 |
| STOCKHOLDERS SHARING THE SAME ADDRESS                                                  |     |   63 |
| OTHER MATTERS                                                                          |     |   63 |

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6055 Lusk Boulevard

San Diego, CA 92121

PROXY STATEMENT FOR THE 2024 ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD ON FRIDAY, JUNE 11, 2025</div>

The board of directors of Crinetics Pharmaceuticals, Inc. is soliciting the enclosed proxy for use at the annual meeting of stockholders on June 11, 2025 at 8:00 a.m., Pacific Time.