Company: DNLI
Filing Date: 2025-02-27
Form Type: S-3ASR
Source: 0001628280-25-008647
Chunk: 44

Company: Denali Therapeutics Inc.
Filing Date: 2025-02-27
Form: S-3ASR
Chunk 44
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 by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

The undersigned registrant hereby undertakes that:

(1) For purposes of determining any liability under the Securities Act of 1933, the information omitted from the form of prospectus filed as part of this registration statement in reliance upon Rule 430A and contained in a form of prospectus filed by the registrant pursuant to Rule 424(b) (1) or (4) or 497(h) under the Securities Act shall be deemed to be part of this registration statement as of the time it was declared effective.

(2) For the purpose of determining any liability under the Securities Act of 1933, each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

<div align='center'>II - 5</div>

### EXHIBIT INDEX
| Exhibit Number 
 1.1*           
 1.2            
 3.1            |     | Description                                                                                                                                            
 Form of Underwriting Agreement.                                                                                                                        
 Equity Distribution Agreement, dated February 27, 2025 between the Registrant and Goldman Sachs & Co. LLC and Leerink Partners LLC.                    
 Amended and Restated Certificate of Incorporation of the Registrant.                                                                                   |     | Form  
 —     
 8-K   |     | File No.   
 —          
 001-38311  |     | Exhibit 
       — 
     3.1 |     | Filing Date    
 Filed herewith 
 12/12/2017     |
|:---------------|:----|:-------------------------------------------------------------------------------------------------------------------------------------------------------|:----|:------|:----|:-----------|:----|--------:|:----|:---------------|
| 3.2            |     | Amended and Restated Bylaws of the Registrant.                                                                                                         |     | 8-K   |     | 001-38311  |     |     3.1 |     | 11/18/2024     |
| 4.1            |     | Specimen common stock certificate of the Registrant.                                                                                                   |     | S-1/A |     | 333-221522 |     |     4