Company: IOBT
Filing Date: 2025-04-07
Form Type: S-8
Source: 0001193125-25-074645
Chunk: 1

Company: IO Biotech, Inc.
Filing Date: 2025-04-07
Form: S-8
Chunk 1
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 the contents of the Registrant’s prior Registration Statement on Form S-8filed with the Securities and Exchange Commission (the “Commission”) on March 11, 2024(SEC File No. 333-277826), February 6, 2023(SEC File. No. 333-269597),and February 8, 2022(SEC File No. 333-262587)(collectively, the “Prior Registration Statements”). This Registration Statement relates to securities of the same class as those to which the prior Registration Statements relate and is submitted in accordance with General Instruction E of Form S-8regarding Registration of Additional Securities. Pursuant to General E of Form S-8,the contents of the Prior Registration Statements, are incorporated herein by reference and made part of this Registration Statement, except for Items 3 and 8, which are being updated by this Registration Statement. PART I INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS All information required by Part I to be contained in the prospectus is omitted from this Registration Statement in accordance with the explanatory note to Part I of Form S-8and Rule 428 under the Securities Act of 1933, as amended (the “Securities Act”). Documents containing the information required by Part I of the Registration Statement will be sent or given to plan participants as specified by Rule 428(b)(1) of the Securities Act. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT Item 3. Incorporation of Documents by Reference. The following documents, which have been filed with the Commission by the Registrant are incorporated in this Registration Statement by reference (excluding any portions of such documents that have been “furnished” but not “filed” for purposes of the Securities Exchange Act of 1934, as amended (the “Exchange Act”)):

| (1) | The Registrant’s Annual Report on Form                                                         
 10-K for the fiscal year ended December 31, 2024, filed with the Commission on March 31, 2025; |

| (2) | The description of the Common Stock included in the Registrant’s Registration Statement on Form                                      
 8-A, filed with the Commission on November 2, 2021, including any subsequent amendments or reports filed to update such description. |

All documents subsequently filed by the Registrant with the Commission pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this Registration Statement