Company: RCUS
Filing Date: 2025-02-25
Form Type: S-8
Source: 0001724521-25-000042
Chunk: 1

Company: Arcus Biosciences, Inc.
Filing Date: 2025-02-25
Form: S-8
Chunk 1
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   |     | Emerging growth company   |     | ☐ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act ☐.

### EXPLANATORY NOTE
Pursuant to General Instruction E to Form S-8, this Registration Statement is being filed with the U.S. Securities and Exchange Commission (the “SEC”) for the purpose of registering an additional number of securities of the same class as other securities for which a Registration Statement on Form S-8 relating to the same employee benefit plans is effective. Specifically, this Registration Statement is being filed to register (i) 3,570,000 additional shares of common stock of Arcus Biosciences, Inc. (the “Registrant”) for issuance under the Arcus Biosciences, Inc. 2018 Equity Incentive Plan and (ii) 922,017 additional shares of common stock of the Registrant for issuance under the Arcus Biosciences, Inc. 2018 Employee Stock Purchase Plan, in each case, pursuant to the provisions of such plans that provide for automatic annual increases in the number of shares reserved for issuance thereunder. This Registration Statement hereby incorporates by reference the contents of the Registrant’s Registration Statements on Form S-8 filed with the Commission on March 16, 2018 (File No. 333-223746 ), March 5, 2019 (File No. 333-230074 ), March 5, 2020 (File No. 333-236915 ), February 25, 2021 (File No. 333-253474 ), February 23, 2022 (File No. 333-262929 ), February 28, 2023 (File No. 333-270114 ) and February 21, 2024 (File No. 333-277219 ) (the "Prior Forms S-8") pursuant to General Instruction E to Form S-8.

# PART II
<div align='center'>Information Required in the Registration Statement</div>

## Item 3. Incorporation of Documents by Reference
The Registrant hereby incorporates by reference into this Registration Statement the Prior Form S-8 and the following documents previously filed with the SEC:

| (a) 
 (b) |     | the Registrant’s Annual Report onForm10-Kfor the