Company: SHPH
Filing Date: 2025-12-11
Form Type: S-1/A
Source: 0001493152-25-027310
Chunk: 6

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-12-11
Form: S-1/A
Chunk 6
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pharma.com. Our Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K, and all amendments to those reports, if any, are available to you free of charge through the “Investor Relations” section of our website as soon as reasonably practicable after such materials have been electronically filed with or furnished to the SEC. Information contained on our website does not form a part of this prospectus.

Private Placement

On November 3, 2025, we entered into a securities purchase agreement (the “Purchase Agreement”) with an accredited investor, for the sale by the Company to the investor, in a private placement, of a pre-funded warrant to purchase up to 625,156 shares of common stock for aggregate gross proceeds of approximately $2.5 million. The private placement closed on November 4, 2025.

The pre-funded warrant is immediately exercisable, at a nominal exercise price of $0.001, and may be exercised at any time until the pre-funded warrant is exercised in full. The pre-funded warrant may not be exercised to the extent such exercise would result in the holder beneficially owning more than 4.99% of the Company’s outstanding common stock.

Pursuant to the Purchase Agreement, the Company agreed to file a registration statement with the SEC to register for resale the shares of the shares issuable upon exercise of the pre-funded warrant issued under the Purchase Agreement within 15 days of the date of the Purchase Agreement, and to have such registration statement declared effective within 45 days of the date of the Purchase Agreement (or 75 days if the registration statement is reviewed by the SEC).

WestPark Capital, Inc. (“WestPark”) acted as the placement agent in connection with the private placement pursuant to a placement agency agreement between the Company and WestPark (as amended, the “Placement Agency Agreement”). Pursuant to the Placement Agency Agreement, the Company paid WestPark a cash fee of 4% of the gross proceeds received by the Company in the private placement. The Company also reimbursed certain expenses of WestPark.

This prospectus covers the resale of the 625,156 shares of common stock issuable upon exercise of the pre-funded warrant issued under the Purchase Agreement.

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<div align='center'>RISK FACTORS</div>

An investment in our securities involves a high degree of risk. Before deciding whether to invest in our securities, you should consider carefully the risks and uncertainties discussed below, as well as those under the