Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 375

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 375
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 | 115,895 |
| Dorman Followwill              |     | $           | 170,545 |     | $             | 131,400 |     |                  | — |     | $         | 301,945 |
| Yue Alexander Wu, Ph.D.        |     | $           | 127,500 |     | $             |  42,770 |     |                  | — |     | $         | 170,270 |
| Annu Navani, M.D.(3)           |     | $           |       — |     | $             | 239,225 |     |                  | — |     | $         | 239,225 |
| Former Non-Employee Director   |     |             |         |     |               |         |     |                  |   |     |           |         |
| David Lemus(4)                 |     | $           | 120,000 |     | $             |  88,630 |     |                  | — |     | $         | 208,630 |

| (1) | Dr. Ji, our Executive Chairperson, and Mr. Shah, our Chief Executive Officer and President, are not     
 included in this table, as each of them was our employee and therefore receives no compensation for his |

238

| service as a director. Dr. Ji’s and Mr. Shah’s compensation as named executive officers are included in the section titled “Executive and Director Compensation — 
 Summary Compensation Table” above.                                                                                                                                |

| (2) | As of December 31, 2024, each of our current non-employee                                                                                                            
 directors held options to purchase the following number of shares of our Common Stock: Dr. Chun: 2,857; Mr. Followwill: 5,685; Dr. Wu: 2,857; and Dr. Navani: 7,142. |

| (3) | Dr. Navani was appointed to our Board on July 21, 2024. |

| (4) | Mr. Lemus resigned from our Board effective November 27, 2024. As of December 31, 2024, Lemus 
 held options to purchase 71 shares of our Common Stock.                                       |

Non-EmployeeDirector Compensation Pursuant to our Non-EmployeeDirector Compensation Policy for the compensation of our non-employeedirectors, during 2024, each of our non-employeedirectors received annual retainers,