Company: SCLXW
Filing Date: 2025-11-07
Form Type: DEF 14A
Source: 0001193125-25-272322
Chunk: 2

Company: Scilex Holding Co
Filing Date: 2025-11-07
Form: DEF 14A
Chunk 2
---
 PROPOSAL NO. 1: APPROVAL OF THE REPRICING OF CERTAIN STOCK OPTIONS GRANTED UNDER 
 THE 2022 PLAN                                                                    |     |      |  8 |
| PROPOSAL NO. 2: APPROVAL OF THE ADJOURNMENT OF THE SPECIAL                       
 MEETING                                                                          |     |      | 15 |
| SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND                              
 MANAGEMENT                                                                       |     |      | 23 |
| HOUSEHOLDING OF PROXY MATERIALS                                                  |     |      | 25 |
| OTHER MATTERS                                                                    |     |      | 25 |

i

SCILEX HOLDING COMPANY PROXY STATEMENT FOR SPECIAL MEETING OF STOCKHOLDERS PROCEDURAL MATTERS This proxy statement (this “Proxy Statement”) and the enclosed form of proxy are furnished in connection with the solicitation of proxies by our board of directors (our “Board”) for use at the Special Meeting of Stockholders (the “Special Meeting”) of Scilex Holding Company, a Delaware corporation (the “Company”, “Scilex”, “we”, “us” or “our”), and any adjournments or postponements thereof. The Special Meeting will be held virtually on Thursday, December 11, 2025, at 9:00 a.m. Pacific Time via live audio webcast. This Proxy Statement and the accompanying proxy card are first being mailed on or about November 10, 2025 to all stockholders of record entitled to vote at the Special Meeting. The information provided in the “question and answer” format below is for your convenience only and is merely a summary of the information contained in this Proxy Statement. You should read this entire Proxy Statement carefully. Information contained on, or that can be accessed through, our website is not intended to be incorporated by reference into this Proxy Statement, and references to our website address in this Proxy Statement are inactive textual references only. What matters am I voting on? You will be voting on:

| • |     | The approval of the repricing of certain outstanding stock options issued under the Scilex Holding Company 2022                                        
 Equity Incentive Plan, as amended (the “2022 Plan”), that are held by eligible service providers of the Company (the “Option Repricing Proposal”); and |

| • |     | The approval of the adjournment of the Special Meeting, if necessary, to solicit additional proxies if there are               
 not sufficient votes at the time of the Special