Company: SNY
Filing Date: 2025-10-29
Form Type: 424B5
Source: 0001193125-25-255563
Chunk: 95

Company: Sanofi
Filing Date: 2025-10-29
Form: 424B5
Chunk 95
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 holding at least a majority of the principal amount of the outstanding debt securities of each affected series. ( Section 1008) For the purpose of this covenant, “Relevant Indebtedness” means any payment obligation being borrowed money, whether present or future (including, without limitation, any contingent obligation, any surety or other obligation), which is for, or in respect of, or represented by any bonds, debentures, or other form of debt securities capable in the ordinary course of being listed, quoted or ordinarily dealt in on any stock exchange, over-the-countermarket or securities market. For the avoidance of doubt, nothing in this section “— Negative Pledge” shall prevent us from depositing funds in trust in connection with any transaction or operation contemplated by the section “— Defeasance and Discharge” and relating to any series of debt securities issued from time to time hereunder. Discharge or defeasance The indenture contains a provision that permits us to elect:

| • |     | to be discharged from all our obligations (subject to limited exceptions) with respect to any series of debt 
 securities then outstanding; and/or                                                                          |

| • |     | to be released from our obligations under some of the covenants and from the consequences of an event of default 
 resulting from a breach of such covenants.                                                                       |

We can legally release ourselves from any payment or other obligations on the debt securities of a series under either of the above elections, except for various obligations described below, if we, in addition to other actions, put in place the following arrangements for you to be repaid:

| • |     | We must deposit in trust for your benefit and the benefit of all other direct holders of the debt securities of a 
 series a combination of money and/or U.S. government or U.S. government agency notes or bonds                     |

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| that will generate enough cash to make interest, principal and any other payments on the debt securities of such series on their various due dates. In addition, on the date of such deposit, we                                 
 must not be in default. For purposes of this no-default test, a default would include an event of default that has occurred and not been cured, as described under “— Default and Related Matters                                
 — Events of Default — What is An Event of Default?” below. A default for this purpose would also include any event that would be an event of default if the requirements for giving us default notice under the indenture or our 
 default having to continue