Company: CIO
Filing Date: 2025-05-16
Form Type: S-8
Source: 0001193125-25-121681
Chunk: 3

Company: City Office REIT, Inc.
Filing Date: 2025-05-16
Form: S-8
Chunk 3
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 Form 10-Q filed on May 23, 2014).                                             |
| 4.5     |     | Amendment No.                                                                                                                                                                          
 1 to the City Office REIT, Inc. Equity Incentive Plan (incorporated by reference to Exhibit 10.1 to the Registrant’s Current Report on Form 8-K filed on May 6, 2019).                 |
| 4.6     |     | Amendment No.                                                                                                                                                                          
 2 to the City Office REIT, Inc. Equity Incentive Plan (incorporated by reference to Exhibit A to the Registrant’s Definitive Proxy Statement on Schedule 14A filed on March 16, 2022). |
| 4.7     |     | Amendment No.                                                                                                                                                                          
 3 to the City Office REIT, Inc. Equity Incentive Plan (incorporated by reference to Exhibit A to the Registrant’s Definitive Proxy Statement on Schedule 14A filed on March 12, 2025). |
| 5.1*    |     | Opinion of Ballard Spahr LLP.                                                                                                                                                          |
| 23.1*   |     | Consent of KPMG LLP.                                                                                                                                                                   |
| 23.2*   |     | Consent of Ballard Spahr LLP (included in Exhibit 5.1 to this Registration Statement).                                                                                                 |
| 24.1*   |     | Power of Attorney (included in the signature pages to this Registration Statement).                                                                                                    |
| 107*    |     | Calculation of Filing Fee Table                                                                                                                                                        |

| * | Filed herewith. |

3

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Vancouver, Canada, on May 16, 2025.

| CITY OFFICE REIT, INC. |     |                                      |
| By:                    |     | /s/ James Farrar                     |
| Name:                  |     | James Farrar                         |
| Title:                 |     | Chief Executive Officer and Director |

4

POWER OF ATTORNEY KNOW ALL MEN BY THESE PRESENTS, that the undersigned directors and officers of the Registrant, which is filing a Registration Statement