Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 35

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 35
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 our Common Stock and Public Warrants | Our Common Stock is listed on the Nasdaq Capital Market under the symbol “SCLX”. Our Public Warrants are listed on the Nasdaq Capital Market under the symbol “SCLXW”. |

| Risk factors | See “Risk Factors” beginning on page 23 and other information included in this prospectus for a discussion of factors you should carefully consider before deciding to invest in the securities being offered by this prospectus. |

| (1) | The number of shares of Common Stock outstanding assumes that an aggregate of 6,951,671 shares are outstanding                                                                                                                                     
 immediately prior to the completion of this offering, which number is based on an aggregate of 6,951,671 shares outstanding as of December 31, 2024, taking into account the Reverse Stock Split, with no additional shares of Common Stock issued 
 after December 31, 2024 and on or prior to March 31, 2025, and excludes:                                                                                                                                                                           |

| • |     | 18,665 shares of Common Stock issuable upon the exercise of stock options outstanding under the 2017 Scilex                            
 Pharmaceuticals Inc. Equity Incentive Plan (the “Scilex Pharma 2017 Plan”) with a weighted average exercise price of $26.95 per share; |

| • |     | 432,087 shares of Common Stock issuable upon the exercise of stock options outstanding under the 2019 Stock            
 Option Plan of Scilex, Inc. (the “2019 Stock Option Plan”) with a weighted average exercise price of $60.55 per share; |

| • |     | 571,738 shares of Common Stock issuable upon the exercise of stock options outstanding under the Scilex Holding                
 Company 2022 Equity Incentive Plan (the “Equity Incentive Plan”), with a weighted average exercise price of $200.55 per share; |

| • |     | up to 494,662 shares of Common Stock available for future issuance under the Equity Incentive Plan; |

| • |     | up to 118,350 shares of Common Stock available for future issuance under the Scilex Holding Company 2022 Employee 
 Stock Purchase Plan (the “ESPP”);                                                                                 |

| • |     | up to 40,000 shares of Common Stock available for future issuance under the Scilex Holding Company 2023 
 Inducement Plan (the “Inducement Plan”);                                                                |

| •