Company: PSTV
Filing Date: 2025-05-01
Form Type: DEFA14A
Source: 0000950170-25-061484
Chunk: 2

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-05-01
Form: DEFA14A
Chunk 2
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 firm provides you. Many brokerage firms also offer the option of voting over the Internet or by telephone, instructions for which, if available, would be provided by your brokerage firm on the voting instruction form that it delivers to you. Because most brokerage firms are member organizations of the New York Stock Exchange (“NYSE”), the rules of the NYSE govern how your brokerage firm would be permitted to vote your shares in the

absence of instruction from you. Under the current rules of the NYSE, if you do not give instructions to your brokerage firm, it will still be able to vote your shares with respect to certain “discretionary” items, but will not be allowed to vote your shares with respect to certain “non-discretionary” items.We now expect that the Reverse Stock Split Proposal, Authorized Common Stock Increase Proposal and Adjournment Proposal will be considered to be discretionary items under the NYSE rules, and your brokerage firm will be able to vote your shares with respect to such proposals even if it does not receive instructions from you, so long as it holds your shares in its name, in which case those shares will not be considered broker non-votes.Information on how to vote is at the bottom of this message.

For more information on the Special Meeting, see our Proxy Statement, available on our website at https://ir.plustherapeutics.com/reports-filings/sec-filings.

On behalf of the Board of Directors, thank you for your continued support of Plus Therapeutics, Inc.

Sincerely,

/s/ Marc H. Hedrick

Marc H. Hedrick

President & Chief Executive Officer

Your vote is important.Even if you plan to attend the Special Meeting, please vote as soon as possible using one of the following options:

<div align='center'>TIME IS SHORT-PLEASE VOTE TODAY!

You can vote your shares online or by phone.

Please use the control number found on your previously received proxy card and visit

www.proxyvote.comto submit your instructions online, or

if you received your original proxy statement by email, you may simply click
the “VOTE NOW” button in the email.

To vote by phone, call the phone number listed on your proxy card or voting instruction form.</div>