Company: MIRM
Filing Date: 2025-09-09
Form Type: S-8
Source: 0001759425-25-000045
Chunk: 1

Company: Mirum Pharmaceuticals, Inc.
Filing Date: 2025-09-09
Form: S-8
Chunk 1
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 Non-accelerated filer   |     | ☐ |     | Smaller reporting company |     | ☐ |
|                         |     |   |     | Emerging growth company   |     | ☐ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

### EXPLANATORY NOTE
This Registration Statement on Form S-8 (this “

#### Registration Statement
”) is being filed by Mirum Pharmaceuticals, Inc. (the “

#### Registrant
”) for the purpose of registering 1,500,000 additional shares of the Registrant’s common stock, par value $0.0001 (“Common Stock”), under the Registrant’s 2020 Inducement Plan (the “

#### 2020 Inducement Plan
”) for an aggregate of 5,500,000 shares of Common Stock issuable under the 2020 Inducement Plan, pursuant to approval of the Compensation Committee of the Registrant’s Board of Directors.

These additional shares of Common Stock are securities of the same class as other securities for which Registration Statements of the Registrant on Form S-8 relating to the same employee benefit plans are effective.

# PART II

### INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

## Item 3. Incorporation of Documents by Reference.
The Registrant previously registered shares of Common Stock for issuance under the 2020 Inducement Plan pursuant to (i) a Registration Statement on Form S-8 (File No. 333-238086) filed with the Securities and Exchange Commission (the “

#### Commission
”) on May 7, 2020, (ii) a Registration Statement on Form S-8 (File No. 333-254043) filed with the Commission on March 9, 2021, (iii) a Registration Statement on Form S-8 (File No. 333-263397) filed with the Commission on March 9, 2022 and (iv) a Registration Statement on Form S-8 (File No. 333-275283) filed with the Commission on November 2, 2023 (collectively, the “

#### Prior Registration Statements
”). In accordance with General Instruction E to Form S-8, the contents of the Prior Registration Statements are hereby incorporated by reference.

The Registr