Company: SXTPW
Filing Date: 2025-01-30
Form Type: 424B5
Source: 0001213900-25-008098
Chunk: 52

Company: 60 DEGREES PHARMACEUTICALS, INC.
Filing Date: 2025-01-30
Form: 424B5
Chunk 52
---
 (Emerg Infect Dis 2021;27:616-61)          
 who reported that 476,000 cases of Lyme disease occur in U.S. states where babesiosis is           
 endemic and Krause et. al. (JAMA 1996;275:1657-16602) who reported that 10% of Lyme disease        
 patients are co-infected with babesiosis and that according to Krause et al (AJTMH 2003;6:431-436) 
 fact that about 80% of cases are symptomatic (thus 476,000*10%*80% = 38,000 cases of babesiosis    
 per year).                                                                                         |

| 11 | Bloch                                           
 et al Open Forum Infect Dis 2022;9(11):ofac597. |

| 12 | According           
 to IDSA guidelines. |

| 13 | See                                                                                                                                                                        
 Krause et al Clin Infect Dis 2024; doi:10.1093/cid/ciae238 and https://ysph.yale.edu/news-article/antimalarial-drug-is-effective-against-tick-borne-infection-babesiosis/. |

| 14 | Marx                           
 et. al., MMWR 2021;70:612-616. |

| 15 | https://www.cdc.gov/fungal/diseases/candidiasis/invasive/statistics.html.; 
 https://www.cdc.gov/fungal/candida-auris/tracking-c-auris.html.            |

| 16 | Dow and                                     
 Smith New Microb New Infect 2022;45:100964. |

<div align='center'>3</div>

| ● | Prevention                                                                                                                            
 of fungal pneumonias. There are up to ~ 91-92,000 new patient cases  each year in the United States for which antifungal              
 prophylaxis is recommended, including acute lymphoblastic leukemia (up to 6,540 cases) and large B-cell lymphoma (up to 18,000 cases) 
 patients receiving CAR-T therapy, solid organ transplant patients (up to 42,887 cases), allogeneic (~ 9,000 cases) and autologous     
 (~ 15,000 cases) hematopoietic stem cell transplant patients.17 Despite the availability and use of antifungal prophylaxis,           
 the risk of some patient groups contracting fungal pneumonia exceeds the risk of contracting malaria during travel to West Africa.18