Company: RNLXY
Filing Date: 2025-07-30
Form Type: 424B3
Source: 0001193805-25-001128
Chunk: 1

Company: Renalytix plc
Filing Date: 2025-07-30
Form: 424B3
Chunk 1
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 of the Shares deposited thereunder and any and all other Deposited
Property (as defined in the Deposit Agreement) from time to time received and held on deposit in respect of the ADSs. Copies of the Deposit
Agreement are on file at the Principal Office of the Depositary and with the Custodian. Each Holder and each Beneficial Owner, upon acceptance
of any ADSs (or any interest therein) issued in accordance with the terms and conditions of the Deposit Agreement, shall be deemed for
all purposes to (a) be a party to and bound by the terms of the Deposit Agreement and the applicable ADR(s), and (b) appoint the Depositary
its attorney-in-fact, with full power to delegate, to act on its behalf and to take any and all actions contemplated in the Deposit Agreement
and the applicable ADR(s), to adopt any and all procedures necessary to comply with applicable law and to take such action as the Depositary
in its sole discretion may deem necessary or appropriate to carry out the purposes of the Deposit Agreement and the applicable ADR(s),
the taking of such actions to be the conclusive determinant of the necessity and appropriateness thereof. The manner in which a Beneficial
Owner holds ADSs (e.g., in a brokerage account vs. as registered holder) may affect the rights and obligations of, the manner in which,
and the extent to which, services are made available to, Beneficial Owners pursuant to the terms of the Deposit Agreement.

The statements made on the
face and reverse of this ADR are summaries of certain provisions of the Deposit Agreement and the Articles of Association of the Company
(as in effect on the date of the signing of the Deposit Agreement) and are qualified by and subject to the detailed provisions of the
Deposit Agreement and the Articles of Association of the Company, to which reference is hereby made.

All capitalized terms not
defined herein shall have the meanings ascribed thereto in the Deposit Agreement.

The Depositary makes no representation
or warranty as to the validity or worth of the Deposited Property. The Depositary has made arrangements for the acceptance of the ADSs
into DTC. Each Beneficial Owner of ADSs held through DTC must rely on the procedures of DTC and the DTC Participants to exercise and be
entitled to any rights attributable to such ADSs. The Depositary may issue Uncertificated ADSs subject, however, to the terms and conditions
of Section 2.13 of the Deposit Agreement.

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