Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 5

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 5
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 ADS and  
 Accompanying 
 Warrants     |     | Per Pre-Funded 
 Warrant and    
 Accompanying   
 Warrants       |     | Total |
|:---------------------------|:----|:-------------|:----|:---------------|:----|:------|
| Public Offering Price      |     | $            |     | $              |     | $     |
| Placement Agent Fees(1)    |     | $            |     | $              |     | $     |
| Proceeds to NuCana (before 
 expenses)(2)(3)            |     | $            |     | $              |     | $     |

| (1) | For a description of the compensation to be received by the Placement Agent, see “Plan of 
 Distribution” starting on page 66 for more information.                                   |

| (2) | Because there is no minimum number of securities or amount of proceeds required as a condition to closing in                                                                                                                                        
 this offering, the actual public offering amount, Placement Agent fees, and proceeds to us, if any, are not presently determinable and may be substantially less than the total maximum offering amounts set forth above. For more information, see 
 “Plan of Distribution.”                                                                                                                                                                                                                             |

| (3) | The amount of offering proceeds to us presented in this table does not give effect to any exercise of the 
 Warrants or the Pre-Funded Warrants.                                                                      |

The delivery to purchasers of the securities against payment is expected to be made on or about , 2025, subject to satisfaction of customary closing conditions. Sole Placement Agent LAIDLAW & COMPANY (UK) LTD. the date of this prospectus is , 2025

Confidential Treatment Requested by Nucana plc Pursuant to 17 C.F.R. Section 200.83 You should rely only on the information contained in this prospectus and any related free-writing prospectus that we authorize to be distributed to you. We have not, and the Placement Agent has not, authorized any person to provide you with information different from that contained in this prospectus or any related free-writing prospectus that we authorize to be distributed to you. This prospectus is not an offer to sell, nor is it seeking an offer to buy, these securities in any jurisdiction where the offer or sale is not permitted. The information in this prospectus speaks only as of the date of this prospectus unless the information specifically indicates that another date applies, regardless of the time of delivery of this prospectus or