Company: SCLXW
Filing Date: 2025-05-07
Form Type: POS AM
Source: 0001193125-25-115095
Chunk: 7

Company: Scilex Holding Co
Filing Date: 2025-05-07
Form: POS AM
Chunk 7
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 hereunder. The Selling Securityholders will bear all commissions and discounts, if any, attributable to their respective sales of the Resale Shares and the Private Warrants.

Our Common Stock is listed on the Nasdaq Capital Market under the symbol “SCLX”. On May 5, 2025, the last reported sales price per share of our Common Stock was $5.43. Our Public Warrants are listed on the Nasdaq Capital Market under the symbol “SCLXW.” On May 5, 2025, the closing sale price per warrant of our Public Warrants was $0.075.

On April 15, 2025, we effected a reverse stock split of our Common Stock at a ratio of 1-for-35 (the “Reverse Stock Split”). Unless otherwise noted, the share and per share information in this prospectus reflects the effect of the Reverse Stock Split. The Company’s historical financial statements included in this prospectus do not reflect the Reverse Stock Split.

We are an “emerging growth company” as that term is used in the Jumpstart Our Business Startups Act of 2012 (the “JOBS Act”) and, as such, we have elected to comply with certain reduced public company reporting requirements for this prospectus and future filings with the Securities and Exchange Commission.

We may amend or supplement this prospectus from time to time by filing amendments or supplements as required. You should read this prospectus, together with additional information described under the heading “Where You Can Find More Information”, and any amendments or supplements carefully before you invest in any of our securities.

INVESTING IN OUR COMMON STOCK INVOLVES SUBSTANTIAL RISKS. YOU SHOULD REVIEW CAREFULLY THE RISKS AND UNCERTAINTIES DESCRIBED UNDER THE HEADING “RISK FACTORS” BEGINNING ON PAGE 23 OF THIS PROSPECTUS.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.

<div align='center'>**The date of this prospectus is , 2025**</div>

#### TABLE OF CONTENTSPageABOUT THIS PROSPECTUS1CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS2CERTAIN DEFINED TERMS4PROSPECTUS SUMMARY9THE OFFERING20RISK FACTORS23MARKET AND INDUSTRY DATA104USE OF PROCEEDS105DE