Company: SCLXW
Filing Date: 2025-11-24
Form Type: 424B3
Source: 0001193125-25-293873
Chunk: 8

Company: Scilex Holding Co
Filing Date: 2025-11-24
Form: 424B3
Chunk 8
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 (provided no additional exercise price shall be due and payable). The parties hereby agree that the Beneficial Ownership Limitation for
purposes of the Existing Warrants is as set forth on the Holder’s signature page hereto.

Expressly subject to the
paragraph immediately following this paragraph below, Holder may accept this offer by signing this letter agreement below, with such acceptance constituting Holder’s exercise in full of the Existing Warrants for an aggregate exercise price as
set forth on the Holder’s signature page hereto on or before 7:00 p.m., Eastern Time, on November 23, 2025 (the “”).

Additionally, the Company agrees to the representations, warranties and covenants set forth on attached hereto. Holder represents and warrants that, as of the date hereof it is, and on each date on which it exercises any New Warrants it will be, an “accredited investor” as defined in Rule 501 of Regulation D promulgated
under the Securities Act, and agrees that the New Warrants will contain restrictive legends when issued, and neither the New Warrants nor New Warrant Shares will be registered under the Securities Act, except as provided in attached hereto. Also, Holder represents and warrants that it is acquiring the New Warrants as principal for its own account and has no direct or indirect arrangement or understandings with any other persons to distribute or regarding the
distribution of the New Warrants or the New Warrant Shares (this representation is not limiting Holder’s right to sell the New Warrant Shares pursuant to an effective registration statement under the Securities Act or otherwise in compliance
with applicable federal and state securities laws).

The Holder understands that the New Warrants and the New Warrant
Shares are not, and may never be, registered under the Securities Act, or the securities laws of any state and, accordingly, each certificate, if any, representing such securities shall bear a legend substantially similar to the following:

“THIS SECURITY HAS NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES
COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT