Company: AZN
Filing Date: 2025-06-26
Form Type: 11-K
Source: 0001683168-25-004771
Chunk: 0

Company: ASTRAZENECA PLC
Filing Date: 2025-06-26
Form: 11-K
Chunk 0
---
<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 11-K</div>

☒ANNUAL REPORT PURSUANT TO SECTION 15 (d) OF THE SECURITIES EXCHANGE ACT OF 1934

<div align='center'>For the fiscal year ended
December 31, 2024

OR</div>

☐ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

<div align='center'>for the transition
period from to

Commission file number 001-11960</div>

| A. | Full title of the plan and the address of the plan, if different from that of the issuer named below: |

<div align='center'>ASTRAZENECA SAVINGS AND SECURITY PLAN

AstraZeneca Pharmaceuticals LP

1800 Concord Pike

P.O. Box 15437

Wilmington, DE 19850-5437</div>

| B. | Name of issuer of the securities held pursuant to the plan and the address of its principal executive office: |

<div align='center'>AstraZeneca PLC

1 Francis Crick Avenue

Cambridge Biomedical Campus

Cambridge CB2 OAA

United Kingdom</div>

1.:

The following financial information, including
Report of Independent Registered Public Accounting Firm thereon of the AstraZeneca Savings and Security Plan are submitted herewith:

Statements of Net Assets Available
for Plan Benefits as of December 31, 2024 and 2023;

Statements of Changes in Net Assets
Available for Plan Benefits for the years ended December 31, 2024 and 2023; and

Notes to Financial Statements.

Supplemental Schedule: Schedule H, line 4i - Schedule
of Assets (Held at End of Year).

The schedule for which
provision is made in the applicable accounting regulations of the Securities and Exchange Commission are included in the
aforementioned financial statements of the AstraZeneca Savings and Security Plan.

2.:

The following exhibit is submitted herewith:

Exhibit 23.1 - Consent of Independent Registered Public Accounting Firm

| 1 |

<div align='center'>ASTRAZENECA SAVINGS AND SECURITY PLAN

Table of Contents

December 31, 2024 and 2023</div>

|                                                                | Page(s) |
| Report of Independent Registered Public Accounting Firm