Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 214

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 214
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 exemption from new or revised accounting standards and, therefore, will
be subject to the same new or revised accounting

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standards as other public companies that are not emerging growth companies. As a result, changes in rules of U.S. generally accepted accounting principles or their interpretation, the adoption of new guidance or the application of existing guidance to changes in Scilex’s business could significantly affect our business, financial condition and results of operations. In addition, we are in the process of evaluating the benefits of relying on the other exemptions and reduced reporting requirements provided by the JOBS Act. Subject to certain conditions set forth in the JOBS Act, as an emerging growth company we may take advantage of certain exemptions from various reporting requirements and other burdens that are otherwise applicable generally to public companies. These provisions include, but are not limited to:

| • |     | an exemption from compliance with the requirement to obtain an attestation and report from our auditors on the 
 assessment of our internal control over financial reporting pursuant to the Sarbanes-Oxley Act;                |

| • |     | an exemption from compliance with any new requirements adopted by the Public Company Accounting Oversight Board 
 requiring mandatory audit firm rotation;                                                                        |

| • |     | reduced disclosure about our executive compensation arrangements in our periodic reports, proxy statements and 
 registration statements; and                                                                                   |

| • |     | exemptions from the requirements of holding non-binding advisory votes on 
 executive compensation or golden parachute arrangements.                  |

Scilex qualifies and will remain as an emerging growth company until the earlier of (i) the last day of the fiscal year (a) following the fifth anniversary of the closing of the IPO, (b) in which Scilex has total annual gross revenue of at least $1.235 billion, or (c) in which Scilex is deemed to be a large accelerated filer, which means the market value of the common equity of Scilex that is held by non-affiliatesequals or exceeds $700 million as of the last business day of its most recently completed second fiscal quarter; and (ii) the date on which Scilex has issued more than $1.00 billion in non-convertibledebt securities during the prior three-year period. References herein to “emerging growth company” have the meaning associated with it in the JOBS Act. Smaller Reporting Company Smaller reporting companies may take advantage of certain reduced disclosure obligations, including, among other things, providing only two years of audited financial statements. Sc