Company: NCNA
Filing Date: 2025-05-02
Form Type: F-1/A
Source: 0001193125-25-110310
Chunk: 33

Company: NuCana plc
Filing Date: 2025-05-02
Form: F-1/A
Chunk 33
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 is based on 142,037,199 of our ordinary shares outstanding as of December 31, 2024, and excludes:

| • |     | 17,175,304 ordinary shares issuable upon exercise of outstanding options under our equity compensation 
 plans as of December 31, 2024 at a weighted average exercise price of £2.11 per ordinary share; and    |

| • |     | 29,123 ordinary shares issued upon exercise of options under our equity incentive plans subsequent to December 
 31, 2024 at an exercise price of £0.04 per ordinary share.                                                     |

17

DILUTION If you invest in the ADSs, your interest will be diluted to the extent of the difference between the assumed public offering price per ADS (assuming the exercise for cash of all Pre-FundedWarrants) and our as adjusted net tangible book value per ADS immediately after this offering (assuming the exercise for cash of all Pre-FundedWarrants issued in this offering). Our net tangible book value as of December 31, 2024 was $4.7 million, or $0.03 per ordinary share and $0.83 per ADS, based on 142,037,199 ordinary shares outstanding at December 31, 2024. Net tangible book value represents the amount of total assets minus intangible assets and total liabilities. Net tangible book value per share represents net tangible book value divided by the total number of ordinary shares outstanding. US Dollar amounts are unaudited and have been calculated based on a closing exchange rate of $1.2524 per £1.00, as at December 31, 2024. After giving effect to the sale and issuance, subsequent to December 31, 2024 through the date of this registration statement, of 394,303 ADSs, representing 9,857,575 ordinary shares, pursuant to an “at-the-market” (ATM) sales agreement with Jefferies LLC, resulting in net proceeds, after deducting sales commissions and other related expenses, of £0.5 million, our proforma net tangible book value as of December 31, 2024 would have been $5.3 million, or $0.03 per ordinary share and $0.87 per ADS. After giving effect to the sale of up to 12,497,768 ADSs or up to 12,497,768 Pre-FundedWarrants in lieu of ADSs (and the full exercise of those Pre-Funded