Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063899
Chunk: 1

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 1
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 under the Securities Act, check the following box and list the Securities Act registration statement number of
the earlier effective registration statement for the same offering. ☐

If this Form is a post-effective amendment filed
pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of
the earlier effective registration statement for the same offering. ☐

Indicate by check mark whether the registrant
is an emerging growth company as defined in Rule 405 of the Securities Act or Rule 12b-2 of the Securities Exchange Act of 1934.

Emerging growth company ☐

If an emerging growth company that prepares its
financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition
period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities
Act. ☐

The information in this prospectus is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell and is not soliciting an offer to buy these securities in any jurisdiction where the offer or sale is not permitted.

<div align='center'>SUBJECT TO COMPLETION, DATED [ ], 2025

PRELIMINARY PROSPECTUS

APTORUM GROUP LIMITED

[ ], 2025

Up to [ ] Class A Ordinary Shares</div>

Aptorum Group Limited (the “Company”)
is offering up to ____ Class A ordinary shares, $____ par value per share, or ordinary shares. The assumed public offering price for each
ordinary share is $____, which was the closing price of our ordinary shares on The Nasdaq Capital Market on ____.

This offering will terminate on _____, unless
we decide to terminate the offering (which we may do at any time in our discretion) prior to that date. We will have one closing for all
the securities purchased in this offering. The public offering price per share will be fixed for the duration of this offering.

Our ordinary shares are listed on the Nasdaq Capital
Market (“Nasdaq”) under the symbol “APM.” On ____, 2025, the closing price of our ordinary shares on the Nasdaq
Capital Market was $____ per share. The trading price of our ordinary shares has been, and may continue to be