Company: TEM
Filing Date: 2025-08-27
Form Type: 424B7
Source: 0001193125-25-189854
Chunk: 20

Company: Tempus AI, Inc.
Filing Date: 2025-08-27
Form: 424B7
Chunk 20
---
     |
| ABOUT THIS PROSPECTUS                             |     |      |   i |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |      | iii |
| PROSPECTUS SUMMARY                                |     |      |   1 |
| RISK FACTORS                                      |     |      |   4 |
| USE OF PROCEEDS                                   |     |      |   5 |
| SELLING STOCKHOLDERS                              |     |      |   6 |
| PLAN OF DISTRIBUTION                              |     |      |   8 |
| LEGAL MATTERS                                     |     |      |  11 |
| EXPERTS                                           |     |      |  11 |
| WHERE YOU CAN FIND MORE INFORMATION               |     |      |  11 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE |     |      |  12 |

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and
Exchange Commission (the “SEC”) utilizing a “shelf” registration process as a “well-known seasoned issuer” as defined in Rule 405 under the Securities Act of 1933, as amended (the “Securities Act”).
Under this shelf registration process, the selling stockholders may offer shares of our Class A common stock in one or more offerings. There is no limit on the aggregate number of shares of Class A common stock that the selling
stockholders may offer pursuant to the registration statement of which this prospectus is a part.

The selling stockholders listed under
the heading “Selling Stockholders” in this prospectus may offer and sell up to 2,439,155 shares of our Class A common stock pursuant to this prospectus. In addition, from time to time, selling stockholders to be named in a
prospectus supplement may offer shares of our Class A common stock and, in such case, we will provide a prospectus supplement that will contain more specific information about the terms of that offering. We may also authorize one or more free
writing prospectuses to be provided to you that may contain material information relating to these offerings. Any prospectus supplement and any related free writing prospectus that we may authorize to be provided to you may also add, update or
change any of the information contained in this prospectus or in the documents that we have incorporated by reference into this prospectus. We urge you to read carefully this prospectus, any applicable