Company: APM
Filing Date: 2025-01-03
Form Type: 424B5
Source: 0001213900-25-000606
Chunk: 1

Company: Aptorum Group Ltd
Filing Date: 2025-01-03
Form: 424B5
Chunk 1
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 aggregate market value of our ordinary shares in any 12-month period so long as the aggregate market value of our outstanding ordinary
shares held by non-affiliates remains below US$75,000,000. During the 12 calendar months prior to and including the date of this prospectus
supplement, we have not sold securities in a public primary offering pursuant to General Instruction I.B.5 of Form F-3.

Investors are cautioned that you are buying
shares of a Cayman Islands, Hong Kong, or Nevada-based operating companies but instead are buying shares of a Cayman Islands holding company
with operations conducted by our subsidiaries based in the Cayman Islands, Hong Kong, and Nevada, and that this structure involves unique
risks to investors.

This is an offering of the Class A ordinary shares
of the Cayman Islands holding company. We conduct our business through the subsidiaries in Cayman Islands, Hong Kong, and Nevada. You
will not and may never have direct ownership in the operating entities based in Cayman Islands, Hong Kong, and Nevada.

Throughout this prospectus, unless the context
indicates otherwise, references to “us,” “our,” “Aptorum,” “we,” the “Company,”
the “group” and similar designations refer to Aptorum Group Limited, a Cayman Islands exempted company with limited liability. References to
“Subsidiaries,” or “Operating Subsidiaries” refer to the Aptorum’s subsidiaries established under the laws
of the Cayman Islands, Hong Kong, and Nevada. References to “Group” are to Aptorum and its consolidated subsidiaries collectively.

Investing in our Class A Ordinary Shares involves a high degree of risk. Before buying any Class A Ordinary Shares, you should carefully read the discussion of material risks of investing in our Class A Ordinary Shares in “Risk Factors” beginning on page S-6 of this prospectus supplement.

The information contained or incorporated in this prospectus or in any prospectus supplement is accurate only as of the date of this prospectus, or such prospectus supplement, as applicable, regardless of the time of delivery of this prospectus or any sale of our securities.

Investing in our securities being offered pursuant to this prospectus involves a high degree of risk. You should carefully read and consider the ‘‘Risk Factors’’ section of this prospectus, and risk factors set forth in our most recent annual report on Form 20-F, in other reports incorporated herein by reference,and in the applicable prospectus supplement