Company: TEM
Filing Date: 2025-02-25
Form Type: S-1
Source: 0001193125-25-034442
Chunk: 44

Company: Tempus AI, Inc.
Filing Date: 2025-02-25
Form: S-1
Chunk 44
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, fines, and settlement amounts incurred by any of these individuals in any action or proceeding. We believe that these amended
and restated certificate of incorporation and amended and restated bylaw provisions and indemnification agreements are necessary to attract and retain qualified persons as directors and officers. We also maintain customary directors’ and
officers’ liability insurance.

The limitation of liability and indemnification provisions in our amended and
restated certificate of incorporation and amended and restated bylaws may discourage stockholders from bringing a lawsuit against our directors for breach of their fiduciary duty. They may also reduce the likelihood of derivative litigation against
our directors and officers, even though an action, if successful, might benefit us and other stockholders. Further, a stockholder’s investment may be adversely affected to the extent that we pay the costs of settlement and damage awards against
directors and officers as required by these indemnification provisions.

Insofar as indemnification for liabilities
arising under the Securities Act may be permitted for directors, executive officers, or persons controlling us, we have been informed that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act
and is therefore unenforceable.

29

CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS Other than compensation arrangements for our directors and executive officers, which are described elsewhere in this prospectus, below we describe transactions since January 1, 2022 to which we were a party or will be a party, in which:

| • |     | the amounts involved exceeded or will exceed $120,000; and |

| • |     | any of our directors, executive officers or holders of more than 5% of our capital stock at the time of such                                                                 
 transaction, or any member of the immediate family of, or person sharing the household with, the foregoing persons, had or will have a direct or indirect material interest. |

Series G-3Convertible Preferred Stock Financing In April 2022 and May 2022, we sold an aggregate of 1,614,114 shares of our Series G-3convertible preferred stock at a price per share of $57.3069 for an aggregate purchase price of approximately $92.5 million in private placements to accredited investors. The table below sets forth the number of shares of our Series G-3preferred stock purchased by our executive officers, directors, holders of more than 5% of our capital stock, and their affiliated entities or immediate family members, as applicable.