Company: WSBC
Filing Date: 2025-09-11
Form Type: 424B5
Source: 0001193125-25-201360
Chunk: 78

Company: WESBANCO INC
Filing Date: 2025-09-11
Form: 424B5
Chunk 78
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 of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

The date of this Prospectus is February 27, 2023.

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS               |     |  1 |
| RISK FACTORS                        |     |  2 |
| WHERE YOU CAN FIND MORE INFORMATION |     |  3 |
| FORWARD-LOOKING STATEMENTS          |     |  4 |
| WESBANCO, INC.                      |     |  5 |
| USE OF PROCEEDS                     |     |  6 |
| DESCRIPTION OF DEBT SECURITIES      |     |  7 |
| DESCRIPTION OF CAPITAL STOCK        |     | 16 |
| DESCRIPTION OF OTHER SECURITIES     |     | 20 |
| PLAN OF DISTRIBUTION                |     | 21 |
| LEGAL MATTERS                       |     | 23 |
| EXPERTS                             |     | 23 |

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ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement that we have filed with the Securities and Exchange Commission (the “SEC”),
using an automatic shelf registration process. By using a shelf registration statement, we may sell, from time to time, in one or more offerings, any combination of the securities described in this prospectus. This prospectus does not contain all of
the information in that registration statement. For further information about our business and the securities that may be offered under this prospectus, you should refer to the registration statement and its exhibits. The exhibits to the
registration statement contain the full text of certain contracts and other important documents that we have summarized in this prospectus. Since the summaries in this prospectus may not contain all the information that you may find important in
deciding whether to purchase the securities we may offer, you should review the full text of these contracts and documents. These summaries are qualified in all respects by reference to all of the provisions contained in the applicable contract or
document. The registration statement and its exhibits can be obtained from the SEC as indicated under the heading “Where You Can Find More Information.”

This prospectus only provides you with a general description of the securities we may offer. Each time we sell securities, we will provide a
prospectus supplement that contains specific information about the terms of those securities. The prospectus supplement may also add, update or change information contained in this prospectus. You should read