Company: RCUS
Filing Date: 2025-10-31
Form Type: 424B5
Source: 0001193125-25-260836
Chunk: 38

Company: Arcus Biosciences, Inc.
Filing Date: 2025-10-31
Form: 424B5
Chunk 38
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 the risks described under the heading “ Risk Factors” on page 6 of this prospectus and any similar section contained in the applicable prospectus supplement and in any free writing prospectuses we have authorized for use in connection with a specific offering, and under similar headings in the documents that are incorporated by reference into this prospectus.

This prospectus may not be used to consummate a sale of securities unless accompanied by a prospectus supplement.

The securities may be sold directly by us to investors, through agents designated from time to time or to or through underwriters or dealers,
on a continuous or delayed basis. The supplements to this prospectus will provide the specific terms of the plan of distribution. If any agents or underwriters are involved in the sale of any securities with respect to which this prospectus is being
delivered, the names of such agents or underwriters and any applicable fees, commissions, discounts and option to purchase additional shares will be set forth in a prospectus supplement. The price to the public of such securities and the net
proceeds we expect to receive from such sale will also be set forth in a prospectus supplement.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is February 28, 2023

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS                             |     |  i |
| PROSPECTUS SUMMARY                                |     |  1 |
| RISK FACTORS                                      |     |  6 |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |  7 |
| USE OF PROCEEDS                                   |     |  9 |
| DESCRIPTION OF CAPITAL STOCK                      |     | 10 |
| DESCRIPTION OF DEBT SECURITIES                    |     | 14 |
| DESCRIPTION OF WARRANTS                           |     | 21 |
| LEGAL OWNERSHIP OF SECURITIES                     |     | 23 |
| PLAN OF DISTRIBUTION                              |     | 26 |
| LEGAL MATTERS                                     |     | 28 |
| EXPERTS                                           |     | 28 |
| WHERE YOU CAN FIND ADDITIONAL INFORMATION         |     | 28 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE |     | 28 |

ABOUT THIS PROSPECTUS

This prospectus is part of an automatic registration statement on Form S-3 that we filed