Company: PAYX
Filing Date: 2025-04-09
Form Type: 424B2
Source: 0001193125-25-076822
Chunk: 7

Company: PAYCHEX INC
Filing Date: 2025-04-09
Form: 424B2
Chunk 7
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 and financial condition, may differ materially from those indicated in or suggested by the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following:

| • |     | our ability to keep pace with changes in technology or provide timely enhancements to our solutions and support; |

| • |     | software defects, undetected errors, and development delays for our solutions; |

| • |     | the possibility of cyberattacks, security vulnerabilities or Internet disruptions, including data security and 
 privacy leaks and data loss and business interruptions;                                                        |

| • |     | the possibility of failure of our business continuity plan during a catastrophic event; |

| • |     | the failure of third-party service providers to perform their functions; |

| • |     | the possibility that we may be exposed to additional risks related to our                
 co-employment relationship with our professional employer organization (“PEO”) business; |

| • |     | changes in health insurance and workers’ compensation insurance rates and underlying claim trends; |

| • |     | risks related to acquisitions and the integration of the businesses we acquire, including risks related to the 
 acquisition and integration of Paycor;                                                                         |

| • |     | our clients’ failure to reimburse us for payments made by us on their behalf; |

| • |     | the effect of changes in government regulations mandating the amount of tax withheld or the timing of 
 remittances;                                                                                          |

| • |     | our failure to comply with covenants in our debt agreements; |

| • |     | changes in governmental regulations, laws, and policies; |

| • |     | our ability to comply with U.S. and foreign laws and regulations; |

| • |     | our compliance with data privacy and artificial intelligence laws and regulations; |

| • |     | our failure to protect our intellectual property rights; |

| • |     | potential outcomes related to pending or future litigation matters; |

S-iv

| • |     | the impact of macroeconomic factors on the U.S. and global economy, and in particular on our small- and medium-sized business clients; |

| • |     | volatility in the political and economic environment, including inflation and interest rate changes; |

| • |     | our ability to attract and retain qualified people; |

| • |     | the possible effects of negative publicity on