Company: NCNA
Filing Date: 2025-04-24
Form Type: F-6
Source: 0001193805-25-000556
Chunk: 0

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-6
Chunk 0
---
<div align='center'>SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

_________________________________

FORM F-6

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933 FOR AMERICAN DEPOSITARY
SHARES EVIDENCED BY

AMERICAN DEPOSITARY RECEIPTS

____________

NUCANA PLC

(Exact name of issuer of deposited securities as
specified in its charter)

____________

N/A

(Translation of issuer’s name into English)

____________

England and Wales

(Jurisdiction of incorporation or organization
of issuer)

_________________________________

CITIBANK, N.A.

(Exact name of depositary as specified in its charter)

____________

388 Greenwich Street

New York, New York 10013

(877) 248-4237

(Address, including zip code, and telephone number,
including area code, of depositary’s principal executive offices)

____________

Corporation Service Company

251 Little Falls Drive, Wilmington, DE 19808

United States

(302) 421-6100

(Address, including zip code, and telephone number,
including area code, of agent for service)

_________________________________

Copies to:</div>

| William C. Hicks, Esq.              
 John T. Rudy, Esq.                  
 Allyson Wilkinson, Esq.             
 Mintz, Levin, Cohn, Ferris, Glovsky 
 and Popeo, P.C.                     
 One Financial Center                
 Boston, Massachusetts 02111         
 (617) 542-6000                      |     | Herman H. Raspé, Esq.              
 Jean-Claude Lanza, Esq.            
 Patterson Belknap Webb & Tyler LLP 
 1133 Avenue of the Americas        
 New York, New York 10036           
 (212) 336-2000                     |

<div align='center'>_________________________________</div>

| It is proposed that this filing become effective under Rule                                                      
 466:                                                                                                             | ☐ immediately upon filing. |
|                                                                                                                  | ☐ on (Date) at (Time).     |
| If a separate registration statement has been filed to register the deposited shares, check the following box: ☒ |                            |

<div align='center'>_________________________________

CALCULATION OF REGISTRATION FEE</div>

| Title of Each Class of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
 Securities to be Registered                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       | Amount to be       
 Registered         |          Proposed Maximum 
 Aggregate Price Per Unit