Company: INTS
Filing Date: 2025-03-28
Form Type: DRS
Source: 0001628279-25-000170
Chunk: 6

Company: INTENSITY THERAPEUTICS, INC.
Filing Date: 2025-03-28
Form: DRS
Chunk 6
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 of the securities to be issued under this prospectus or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

|                                    |     | Per Share of 
 Common Stock 
 and          
 Accompanying 
 Common       
 Warrant      |     | Per Pre-Funded 
 Warrant and    
 Accompanying   
 Common         
 Warrant        |     | Total |
|:-----------------------------------|:----|:-------------|:----|:---------------|:----|:------|
| Public offering price(1)           |     | $            |     | $              |     | $     |
| Placement Agents’ fees(2)          |     | $            |     | $              |     | $     |
| Proceeds to us, before expenses(3) |     | $            |     | $              |     | $     |

__________________

(1) The assumed combined public offering price is $ per share of Common Stock and accompanying Common Warrant and $ per Pre-Funded Warrant and accompanying Common Warrant.

(2) Represents a cash fee equal to seven percent (7.0%) of the aggregate purchase price paid by investors in this offering. See “Plan of Distribution” for additional disclosure regarding compensation payable to the Placement Agents.

(3) Does not include proceeds from the exercise of the Common Warrants and/or Pre-Funded Warrants in cash, if any.

Delivery of the securities is expected to be made on or about , 2025, subject to satisfaction of certain conditions.

<div align='center'>Lead Placement Agent</div>

#### A.G.P.
<div align='center'>Co-Placement Agent</div>

#### Brookline Capital Markets,
<div align='center'>a division of Arcadia Securities, LLC</div>

#### The date of this prospectus is , 2025
<div align='center'>Confidential Treatment Requested by Intensity Therapeutics, Inc.</div>

#### Pursuant to 17 C.F.R. Section 200.83

### TABLE OF CONTENTS
| ABOUT THIS PROSPECTUS                                    |     | ii |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS        |     |  1 |
| PROSPECTUS SUMMARY                                       |     |  3 |
| THE OFFERING                                             |     |  6 |
| RISK FACTORS                                             |     |  8 |
| USE OF PROCEEDS                                          |     | 12 |
| MARKET FOR COMMON STOCK AND DIVIDEND