Company: LENZ
Filing Date: 2025-04-14
Form Type: 424B3
Source: 0001628280-25-017694
Chunk: 1

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-14
Form: 424B3
Chunk 1
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 should rely only on the information contained in this prospectus or any prospectus supplement or amendment hereto. We have not authorized anyone to provide you with different information.

Neither the Securities Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is April 14, 2025.</div>

### TABLE OF CONTENTS
|                                                      |     | Page |
| About This Prospectus                                |     |   ii |
| Market and Industry Data                             |     |   ii |
| Trademarks                                           |     |   ii |
| The Company                                          |     |    1 |
| The Offering                                         |     |    3 |
| Risk Factors Summary                                 |     |    4 |
| Risk Factors                                         |     |    6 |
| Cautionary Note Regarding Forward-Looking Statements |     |    7 |
| Use of Proceeds                                      |     |    9 |
| Selling Securityholders                              |     |   10 |
| Description of Securities                            |     |   12 |
| Plan of Distribution                                 |     |   15 |
| Legal Matters                                        |     |   17 |
| Experts                                              |     |   17 |
| Where You Can Find Additional Information            |     |   17 |
| Incorporation by Reference                           |     |   17 |

You should rely only on the information contained in this prospectus, information incorporated by reference into this prospectus or any supplement to this prospectus prepared by us or on our behalf. We have not authorized any other person to provide you with different information. If anyone provides you with different or inconsistent information, you should not rely on it. We are not making an offer to sell these securities in any jurisdiction where the offer or sale is not permitted. You should assume that the information appearing in this prospectus is accurate only as of the date on the front cover of this prospectus and that any information incorporated by reference is accurate only as of the date of the document incorporated by reference, unless we indicate otherwise. Our business, financial condition, results of operations and prospects may have changed since such dates.

<div align='center'>i</div>

### ABOUT THIS PROSPECTUS
This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission (the “SEC”) using the “shelf” registration