Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 104

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 104
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 basis. The engagement agreement does not give rise to any commitment by the Placement Agent to purchase any of our securities, and the Placement Agent will have no authority to bind us by virtue of the engagement agreement. The Placement Agent is not purchasing or selling any of the securities offered by us under this prospectus, nor is the Placement Agent required to arrange for the purchase or sale of any specific number or dollar amount of securities, other than touse its “reasonable best efforts” to arrange for the sale of such securities by us. Therefore, we may not sell all of the securities being offered. The terms of this offering were subject to market conditions and negotiations between us, the Placement Agent and prospective investors. This is a best efforts offering and there is no minimum offering amount required as a condition to the closing of this offering. Because there is no minimum offering amount required as a condition to closing this offering, we may sell fewer than all of the securities offered hereby, which may significantly reduce the amount of proceeds received by us. The Placement Agent does not guarantee that it will be able to raise new capital in any prospective offering. The Placement Agent may engage sub-agentsor selected dealers to assist with the offering. Investors purchasing securities offered hereby will have the option to execute a securities purchase agreement with us. The nature of the representations, warranties and covenants in the securities purchase agreements shall include:

| • |     | standard issuer representations and warranties on matters such as organization, qualification, authorization, no                                                                                                                                         
 conflict, no governmental filings required, current in SEC filings, no litigation, labor or other compliance issues, environmental, intellectual property and title matters and compliance with various laws, such as the Foreign Corrupt Practices Act; 
 and                                                                                                                                                                                                                                                      |

| • |     | covenants regarding matters such as registration of Warrant Shares, no integration with other offerings, filing                                                                                             
 of a 6-K to disclose entering into these securities purchase agreements, no shareholder rights plans, no material nonpublic information, use of proceeds, indemnification of purchasers and reservation and 
 listing of ADSs, as well as prohibitions on subsequent equity sales and variable rate transactions, subject to certain exceptions, for a period of 90 days from the closing date of this offering.          |

We expect to deliver the securities being offered pursuant to this prospectus on or about , 2025, subject to satisfaction of certain customary closing conditions. Fees and Expenses We have agreed to pay the Placement Agent a Placement Agent fee equal to an aggregate of 11.0% of the