Company: TVRD
Filing Date: 2025-11-13
Form Type: 424B3
Source: 0001104659-25-111336
Chunk: 170

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-11-13
Form: 424B3
Chunk 170
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 disasters, and its business continuity and disaster recovery plans may not adequately protect Tvardi from a serious disaster.

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Tvardi’s operations are located in its facilities
in Sugar Land, Texas and it works with third-party CROs and CDMOs globally. Any unplanned event, such as flood, fire, explosion, tornadoes,
extreme weather condition, medical epidemics, power shortage, telecommunication failure or other natural or man-made accidents or incidents
that result in Tvardi being unable to fully utilize its facilities, or the manufacturing facilities of its third-party contract manufacturers,
may have a material and adverse effect on its ability to operate its business and have significant negative consequences on its financial
and operating conditions. Loss of access to these facilities may result in increased costs, delays in the development of Tvardi’s
product candidates or interruption of its business operations. Natural disasters could further disrupt its operations and have a material
and adverse effect on its business, financial condition, results of operations and prospects. If a natural disaster, power outage or other
event occurred that prevented Tvardi from using all or a significant portion of its headquarters, that damaged critical infrastructure,
such as its research facilities or the manufacturing facilities of its third-party contract manufacturers, or that otherwise disrupted
operations, it may be difficult or, in certain cases, impossible, for Tvardi to continue its business for a substantial period of time.

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As part of its risk management policy, Tvardi maintains
insurance coverage at levels that it believes are appropriate for its business. However, in the event of an accident or incident at these
facilities, Tvardi cannot assure you that the amounts of insurance will be sufficient to satisfy any damages and losses. If Tvardi’s
facilities, or the manufacturing facilities of Tvardi’s third-party contract manufacturers, are unable to operate because of an
accident or incident or for any other reason, even for a short period of time, any or all of Tvardi’s research and development programs
may be harmed.

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Risks Related to Ownership of Tvardi’s Common Stock

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The market price of Tvardi’s common stock is expected to be volatile.

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The market price of Tvardi’s common stock
could be subject to significant fluctuations. Market prices for securities of early-stage pharmaceutical, biotechnology and other life
sciences companies have historically been particularly volatile. Some of the factors that may