Company: RCUS
Filing Date: 2025-10-31
Form Type: 424B5
Source: 0001193125-25-260836
Chunk: 51

Company: Arcus Biosciences, Inc.
Filing Date: 2025-10-31
Form: 424B5
Chunk 51
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 that series then outstanding, without any further vote or action by our stockholders. Our board of directors may authorize the issuance of preferred stock with voting or conversion rights that could adversely affect the voting
power or other rights of the holders of the common stock. The issuance of preferred stock, while providing flexibility in connection with possible acquisitions and other corporate purposes, could, among other things, have the effect of delaying,
deferring or preventing a change in control of our company and may adversely affect the market price of our common stock and the voting and other rights of the holders of our common stock.

We will fix the designations, voting powers, preferences and rights of the preferred stock of each series we issue under this prospectus, as
well as the qualifications, limitations or restrictions thereof, in the certificate of

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designation relating to that series. We will file as an exhibit to the registration statement of which this prospectus is a part, or will incorporate by reference from reports that we file with the SEC, the form of any certificate of designation that contains the terms of the series of preferred stock we are offering. We will describe in the applicable prospectus supplement the terms of the series of preferred stock being offered, including, to the extent applicable:

| • |     | the title and stated value; |

| • |     | the number of shares we are offering; |

| • |     | the liquidation preference per share; |

| • |     | the purchase price; |

| • |     | the dividend rate, period and payment date and method of calculation for dividends; |

| • |     | whether dividends will be cumulative or non-cumulative and, if cumulative, the date from which dividends will 
 accumulate;                                                                                                   |

| • |     | the procedures for any auction and remarketing, if applicable; |

| • |     | the provisions for a sinking fund, if applicable; |

| • |     | the provisions for redemption or repurchase, if applicable, and any restrictions on our ability to exercise those 
 redemption and repurchase rights;                                                                                 |

| • |     | any listing of the preferred stock on any securities exchange or market; |

| • |     | whether the preferred stock will be convertible into our common stock, and, if applicable, the conversion price, 
 or how it will be calculated, and the conversion period;                                                         |

| • |     | whether the preferred stock will be exchangeable into debt securities, and, if applicable, the exchange price, or 
 how it will