Company: APM
Filing Date: 2025-10-06
Form Type: S-4
Source: 0001213900-25-096656
Chunk: 6

Company: Aptorum Group Ltd
Filing Date: 2025-10-06
Form: S-4
Chunk 6
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 the Special Meeting or any adjournment or postponement thereof. As described in the accompanying proxy statement/prospectus, Ian Huen, Aptorum’s Chairman and Chief Executive Officer, who beneficially owns 87.05% of Aptorum’s total voting power as of October3, 2025, signed a voting agreement simultaneously with the execution of the Merger Agreement, pursuant to which he agreed to vote in favor of the Proposals. Therefore, Mr.Huen’s vote represents sufficient voting power to approve the proposals without the vote of any other shareholder of Aptorum. Accordingly, all of the proposals will be approved after Mr.Huen submits his vote; no public shareholder votes will be required for the proposals to pass, but you still have the opportunity to vote if you would like to. Aptorum has a dual -classvoting structure consisting of Aptorum Class A ordinary shares and Aptorum Class B ordinary shares. Under this structure, holders of Aptorum Class A ordinary shares are entitled to one vote per share, and holders of Aptorum Class B ordinary shares are entitled to one hundred votes per share, which can cause the

holders of Aptorum Class B ordinary shares to have an unbalanced, higher concentration of voting power. Ian Huen, Aptorum’s current Chairman and Chief Executive Officer, through his ownership of Jurchen, beneficially owning over 1.6million Aptorum Class B ordinary shares, which represents approximately 86.8% voting power in Aptorum. After careful consideration, each of the Aptorum and DiamiR boards of directors has approved the Merger Agreement and the transactions contemplated by the Merger Agreement and have determined that it is advisable to consummate the Merger. The Aptorum board of directors has approved the Proposals and recommends that its shareholders vote “FOR” the proposals described in the accompanying proxy statement/prospectus. Aptorum requests that you sign and return the enclosed proxy or vote by mail or online to ensure that your shares will be represented at the Special Meeting if you are unable to attend. You may change or revoke your proxy at any time before it is voted at the Special Meeting. More information about Aptorum, DiamiR, the Merger Agreement and transactions contemplated thereby and the foregoing proposals is contained in the accompanying proxy statement/prospectus. Aptorum urges you to read the accompanying proxy statement/prospectus carefully and in its entirety. IN PARTICULAR, YOU SHOULD CAREFULLY CONSIDER THE MATTERS DISCUSSED UNDER “ RISK FACTORS ”. Aptorum