Company: XXII
Filing Date: 2025-08-26
Form Type: 424B5
Source: 0001641172-25-025541
Chunk: 23

Company: 22nd Century Group, Inc.
Filing Date: 2025-08-26
Form: 424B5
Chunk 23
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arrants.

The summary of certain terms and provisions of the Warrants is not complete and is subject to, and qualified in its entirety by, the provisions of the form of the Warrant, which was filed with the SEC as an exhibit to a Current Report on Form 8-K on August 25, 2025 in connection with this offering.

Placement Agent Warrants

We are registering placement agent warrants to purchase 567,641 shares of Common Stock. The placement agent warrants have substantially the same terms as the Warrants, except that the placement agent warrants have an exercise price of $2.167 per share of Common Stock. We are also registering up to 567,641 shares of Common Stock issuable up exercise of the placement agent warrants.

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<div align='center'>Legal Matters</div>

The validity of the securities being offered hereby will be passed upon for us by Foley & Lardner LLP, Jacksonville, Florida. Haynes and Boone, LLP, New York, New York is acting as counsel for the placement agent in connection with this offering.

<div align='center'>Experts</div>

The consolidated financial statements to the Annual Report on Form 10-K for the year ended December 31, 2024, are incorporated herein by reference and have been so incorporated in reliance on the report of Freed Maxick P.C., an independent registered public accounting firm, (which contains an explanatory paragraph describing conditions that raise substantial doubt about our ability to continue as a going concern as described in Note 1 to the consolidated financial statements) given on the authority of said firm as experts in auditing and accounting.

<div align='center'>Where You Can Find More Information</div>

We file annual, quarterly and current reports, proxy statements and other information with the SEC. The SEC maintains an Internet website at http://www.sec.gov which contains reports, proxy and information statements and other information regarding issuers that file electronically with the SEC. Our SEC filings are available to the public from the SEC’s Internet website.

This prospectus supplement and the accompanying prospectus are part of a registration statement that we have filed with the SEC relating to the securities to be offered. This prospectus supplement and the accompanying prospectus omit some of the information we have included in the registration statement and the accompanying exhibits and schedules in accordance with the rules and regulations of the SEC, and we refer you to the omitted information. The statements this prospectus supplement makes pertaining to the content of any contract, agreement or other document that is an exhibit to the registration statement