Company: RPTX
Filing Date: 2025-03-03
Form Type: S-8
Source: 0001193125-25-044105
Chunk: 0

Company: Repare Therapeutics Inc.
Filing Date: 2025-03-03
Form: S-8
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As filed with the Securities and Exchange Commission on March 3, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Repare Therapeutics Inc. (Exact name of Registrant as specified in its charter)

| Québec                                   |     | Not applicable     |
| (State or other jurisdiction of          
 incorporation or organization)           |     | -I.R.S. Employer   
 Identification No. |
| 7171 Frederick-Banting, Building 2,      
 Suite 270 St-Laurent, Québec, Canada     |     | H4S 1Z9            |
| (Address of Principal Executive Offices) |     | -Zip Code          |

Repare Therapeutics 2020 Equity Incentive Plan Repare Therapeutics 2020 Employee Share Purchase Plan (Full title of the plan) Lloyd M. Segal Chief Executive Officer Repare Therapeutics Inc. 1 Broadway, 15th Floor Cambridge, MA 02142 +1 857 412 7018 (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies to:

| Divakar Gupta               
 Courtney Thorne Cooley      
 LLP 500 Boylston Street     
 Boston, Massachusetts 02116 
 +1 617 937 2300             |     | Robert Carelli                            
 Jeremy Sculnick Stikeman                  
 Elliott LLP 1155 René-Lévesque Blvd. West 
 41st Floor                                
 Montréal, Québec, Canada H3B 3V2          
 +1 514 397 3222                           |

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-acceleratedfiler, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2of the Exchange Act.

| Large accelerated filer |     | ☐ |     | Accelerated filer         |     | ☐ |
| Non-accelerated filer   |     | ☒ |     | Smaller reporting company |     | ☒ |
|                         |     |   |     | Emerging growth company   |     | ☐ |

If an emerging growth company,