Company: SNY
Filing Date: 2025-10-27
Form Type: 424B5
Source: 0001193125-25-250786
Chunk: 16

Company: Sanofi
Filing Date: 2025-10-27
Form: 424B5
Chunk 16
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 and DTC and its direct and indirect participants (including Euroclear and Clearstream, Luxembourg) will record your beneficial interest on their books. We will not issue certificated notes except in limited circumstances 
 that we explain under “Legal Ownership” in the attached prospectus. Settlement of the notes will occur through DTC in same-day funds. For information on DTC’s book-entry system, see                                                                  
 “Clearance and Settlement” in the attached prospectus.                                                                                                                                                                                                 |

| Additional Notes | We may, at our option, at any time and without giving notice to or seeking the consent of the then-existing noteholders issue additional notes in one or more transactions subsequent to the date of this prospectus supplement with terms (other  
 than the issuance date, the date upon which interest begins to accrue and, in some cases, the first interest payment date) identical to the notes offered hereby. These additional notes will be deemed to be part of the same series as the notes 
 offered hereby and will provide the holders of these additional notes the right to vote together with holders of the notes offered hereby. Such additional notes will be issued with no more than de minimis original issue discount for U.S.      
 federal income tax purposes or be part of a qualified reopening for U.S. federal income tax purposes.                                                                                                                                              |

| Defeasance and Discharge | Subject to certain conditions and exceptions, we may legally release ourselves from any payment or other obligations on the notes, or be released from certain covenants, by depositing funds or obligations issued by the United States government 
 in an amount sufficient to provide for the timely payment of principal, interest and other amounts due under the notes as described under “Description of Debt Securities We May Offer—Special Situations—Defeasance and                            
 Discharge” in the attached prospectus.                                                                                                                                                                                                              |

| Sinking Fund | None. |

| Risk Factors | You should carefully consider all of the information in this prospectus supplement and the attached prospectus, which includes information incorporated by reference. In particular, you should evaluate the specific factors under “Risk 
 Factors” of this prospectus supplement for risks related to an investment in the notes, in addition to the risk factors included in the 2024 Form 20-F.                                                                                   |

| Trustee, Security Registrar, Paying Agent and Calculation Agent | Deutsche Bank Trust Company Americas. |

| Listing | We do not intend to list the notes on any securities exchange or automated quotation system. |

S-13

| Governing