Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 77

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 77
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 which are incorporated by reference into this prospectus. Additional risk factors may also be set forth in any applicable prospectus supplement.

These securities are not deposits or savings accounts but are unsecured obligations of Comerica. These securities are not insured by the Federal Deposit Insurance Corporation or any other governmental agency or instrumentality.

February 9, 2024

TABLE OF CONTENTS

| ABOUT THE PROSPECTUS                                              |     |  1 |
| FORWARD-LOOKING STATEMENTS                                        |     |  1 |
| COMERICA INCORPORATED                                             |     |  2 |
| RISK FACTORS                                                      |     |  3 |
| USE OF PROCEEDS                                                   |     |  3 |
| DESCRIPTION OF CAPITAL STOCK                                      |     |  3 |
| DESCRIPTION OF DEPOSITARY SHARES                                  |     |  7 |
| DESCRIPTION OF DEBT SECURITIES                                    |     | 10 |
| DESCRIPTION OF THE WARRANTS TO PURCHASE COMMON STOCK OR PREFERRED 
 STOCK                                                             |     | 17 |
| DESCRIPTION OF THE WARRANTS TO PURCHASE DEBT SECURITIES           |     | 19 |
| DESCRIPTION OF STOCK PURCHASE CONTRACTS AND STOCK PURCHASE        
 UNITS                                                             |     | 20 |
| PLAN OF DISTRIBUTION                                              |     | 20 |
| ERISA CONSIDERATIONS                                              |     | 22 |
| LEGAL MATTERS                                                     |     | 24 |
| EXPERTS                                                           |     | 24 |
| WHERE YOU CAN FIND MORE INFORMATION                               |     | 24 |

1

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement (the “Registration Statement”) Comerica has filed with the Securities and Exchange Commission
(the “SEC”) under the Securities Act of 1933, as amended (the “Securities Act”) using a “shelf” registration process. Under this shelf process, we are registering an unspecified amount of each class of the securities
described in this prospectus, and may sell any combination of these securities in one or more offerings. It provides you with a general description of the securities Comerica may offer.

Each time Comerica sells securities, Comerica will supplement this prospectus with additional information with specific information about the terms of that
offering. The prospectus supplement may also add to, update, or change information contained in this prospectus. You should read both this prospectus and any prospectus supplement together with the additional information described under the