Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 106

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 106
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 by reference to a specific formula set forth in the stock purchase contracts. The stock purchase contracts may be issued separately or as part of units, often known as stock purchase units, consisting of a stock purchase contract and any combination of:

| • |     | debt securities; |

| • |     | debt obligations of third parties, including U.S. Treasury securities; or |

| • |     | other securities identified in the applicable prospectus supplement, |

which may secure the holders’ obligations to purchase the Common Stock, preferred stock or depositary shares under the stock purchase contracts. The stock purchase contracts may require Comerica to make periodic payments to the holders of the stock purchase units or vice versa, and these payments may be unsecured or prefunded on some basis. The stock purchase contracts may require holders to secure their obligations under those contracts in a specified manner. The applicable prospectus supplement will describe the terms of the stock purchase contracts and stock purchase units, including, if applicable, collateral or depositary arrangements. PLAN OF DISTRIBUTION Comerica may offer the offered securities in one or more of the following ways from time to time:

| • |     | to or through underwriters or dealers; |

| • |     | by itself directly; |

| • |     | through agents; or |

| • |     | through a combination of any of these methods of sale. |

Any such underwriters, dealers or agents may include any broker-dealer subsidiary of Comerica. 20

The prospectus supplement relating to an offering of offered securities will set forth the terms of such offering, including:

| • |     | the name or names of any underwriters, dealers or agents; |

| • |     | the purchase price of the offered securities and the proceeds to Comerica from such sale; |

| • |     | any underwriting discounts and commissions or agency fees and other items constituting underwriters’ or 
 agents’ compensation;                                                                                   |

| • |     | the initial public offering price; |

| • |     | any discounts or concessions to be allowed or reallowed or paid to dealers; and |

| • |     | any securities exchanges on which such offered securities may be listed. |

Any initial public offering prices, discounts or concessions allowed or reallowed or paid to dealers may be changed from time to time. If underwriters are used in an offering of offered securities, such offered securities will be acquired by the underwriters for their own account and may be resold from time to time in