Company: PRME
Filing Date: 2025-02-28
Form Type: S-8
Source: 0001628280-25-008885
Chunk: 1

Company: Prime Medicine, Inc.
Filing Date: 2025-02-28
Form: S-8
Chunk 1
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 or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

# PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

This Registration Statement on Form S-8 (this “Registration Statement”) is being filed for the purpose of registering an additional 6,558,042 shares of common stock, par value $0.00001 per share (“Common Stock”) of Prime Medicine, Inc. (the “Registrant”) available for issuance under the Registrant’s 2022 Stock Option and Incentive Plan, as amended (the “2022 Plan”).

These additional shares of Common Stock are of the same class as other securities relating to the 2022 Plan for which the Registrant’s Registration Statements on Form S-8 ( File No. 333-267953 , File No. 333-270400 , and File No. 333-277567 ), filed with the Securities and Exchange Commission (the “SEC”) on October 19, 2022, March 9, 2023, and March 1, 2024, respectively, are effective (collectively, the “Earlier Registration Statements”).

Pursuant to General Instruction E to Form S-8 regarding registration of additional securities, the contents of the Earlier Registration Statements, except for “Item 8. Exhibits”, are incorporated herein by reference, except to the extent supplemented, amended or superseded by the information set forth herein. Only those items of Form S-8 containing new information not contained in the Earlier Registration Statements are presented herein.

# PART II

### INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

## Item 8. Exhibits.
The exhibits to this Registration Statement are listed in the Exhibit Index attached hereto and incorporated by reference herein.

### EXHIBIT INDEX
| Exhibit 
 number  
 4.1     
 4.2     |     | Description of exhibit                                                                                                                                                                                                                      
 Third Amended and Restated Certificate of Incorporation of Prime Medicine, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on October 24, 2022)                           
 Certificate of Amendment to Third Amended and Restated Certificate of Incorporation of Prime Medicine, Inc. (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K, filed with the SEC on June 12