Company: CERO
Filing Date: 2025-12-05
Form Type: S-1
Source: 0001213900-25-118817
Chunk: 273

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-12-05
Form: S-1
Chunk 273
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 and without taking into account any limitations on conversion of the Preferred Shares or exercise of the PIPE Warrants. Because Keystone may dispose of all, none or some portion of their securities, no estimate can be given as to the number of securities that will be beneficially owned by Keystone upon termination of this offering. For purposes of the table below, however, we have assumed that after termination of this offering, none of the securities covered by this prospectus will be beneficially owned by Keystone and further assumed that Keystone will not acquire beneficial ownership of any additional securities during the offering. In addition, Keystone may have sold, transferred or otherwise disposed of, or may sell, transfer or otherwise dispose of, at any time and from time to time, our securities in transactions exempt from the registration requirements of the Securities Act after the date on which the information in the table is presented. Beneficial ownership is determined in accordance with Rule 13d-3(d) promulgated by the SEC under the Exchange Act, and includes shares of our Common Stock with respect to which the Selling Securityholder have voting and investment power. The percentage of Common Stock beneficially owned by the Selling Securityholder prior to the offering shown in the table below is based on an aggregate of 21,102,671 shares of our Common Stock outstanding on November 24, 2025. Because the purchase price of the Common Stock issuable under the Keystone Purchase Agreements is determined on each Fixed Purchase Date, with respect to a Fixed Purchase, on the applicable VWAP Purchase Date, with respect to a VWAP Purchase, and on the applicable Additional VWAP Purchase Date, with respect to an Additional VWAP Purchase, the number of shares that may actually be sold by us to the Selling Securityholder under the Keystone Purchase Agreements may be more or fewer than the number of shares being offered by this prospectus. We may amend or supplement this prospectus from time to time in the future to update or change the Selling Securityholder list and the securities that may be resold. Please see the section titled “ Plan of Distribution” for further information regarding the Selling Securityholder’s method of distributing these securities. 162

|                                    |     | Common Stock       
 Beneficially Owned |            |     | Maximum Number   
 of Common Stock  
 to be Offered    |             |     | Common           
 Stock Owned      
 After this       
 Offering (1) (2) |             |     |             |      |   |
| Name of Selling Securityholder     |     | Prior to this      
 Offering (