Company: HURA
Filing Date: 2025-10-31
Form Type: 424B3
Source: 0001193125-25-260933
Chunk: 1

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-10-31
Form: 424B3
Chunk 1
---
approved of the securities to be issued under the Prospectus and this prospectus supplement or determined if the Prospectus and this prospectus supplement is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus supplement is October 31, 2025</div>

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

TUHURA BIOSCIENCES, INC. (Exact name of Registrant as Specified in Its Charter)

| Nevada                                                             |     | 001-37823               |     | 99-0360497         |
| (State or Other Jurisdiction                                       
 of Incorporation)                                                  |     | -Commission File Number |     | -IRS Employer      
 Identification No. |
| 10500 University Center Dr., Suite 110                             |     |                         |     |                    |
| Tampa, Florida 33612                                               |     |                         |     |                    |
| (Address of Principal Executive Offices, including zip code)       |     |                         |     |                    |
| Registrant’s Telephone Number, Including Area Code: (813) 875-6600 |     |                         |     |                    |

N/A (Former Name or Former Address, if Changed Since Last Report) Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: ☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) Securities registered pursuant to Section 12(b) of the Act:

| Title of each class                      |     | Trading   
 Symbol(s) |     | Name of each exchange on which registered |
| Common Stock, $0.001 par value per share |     | HURA      |     | The Nasdaq Capital Market                 |

Indicate by check mark whether