Company: SRPT
Filing Date: 2025-03-03
Form Type: S-3ASR
Source: 0001193125-25-044088
Chunk: 27

Company: Sarepta Therapeutics, Inc.
Filing Date: 2025-03-03
Form: S-3ASR
Chunk 27
---
19

PLAN OF DISTRIBUTION We may sell the securities offered through this prospectus (i) to or through underwriters or dealers, (ii) directly to purchasers, including our affiliates, (iii) through agents, or (iv) through a combination of any these methods. The securities may be distributed at a fixed price or prices, which may be changed, market prices prevailing at the time of sale, prices related to the prevailing market prices, or negotiated prices. The prospectus supplement will include the following information:

| • |     | the terms of the offering; |

| • |     | the names of any underwriters or agents; |

| • |     | the name or names of any managing underwriter or underwriters; |

| • |     | the purchase price of the securities; |

| • |     | the net proceeds from the sale of the securities; |

| • |     | any delayed delivery arrangements; |

| • |     | any underwriting discounts, commissions or agency fees and other items constituting underwriters’ or 
 agents’ compensation;                                                                                |

| • |     | any initial public offering price; |

| • |     | any discounts or concessions allowed or reallowed or paid to dealers; and |

| • |     | any commissions paid to agents. |

In addition, the manner in which we or the selling securityholders may sell some or all of the securities covered by this prospectus includes, without limitation, through:

| • |     | a block trade in which a broker-dealer will attempt to sell as agent, but may position or resell a portion of the 
 block, as principal, in order to facilitate the transaction;                                                      |

| • |     | purchases by a broker-dealer, as principal, and resale by the broker-dealer for its account; |

| • |     | ordinary brokerage transactions and transactions in which a broker solicits purchasers; or |

| • |     | privately negotiated transactions. |

We may engage in at-the-marketofferings into an existing trading market in accordance with Rule 415(a)(4). Any at-the-marketoffering will be through an underwriter or underwriters acting as principal or agent for us. We may issue to the holders of our common stock on a pro rata basis for no consideration, subscription rights to purchase shares of our common stock or preferred stock. These subscription rights may or may not be transferable by shareholders. The applicable prospectus supplement will describe the specific terms of any offering of our common or preferred stock