Company: ARWR
Filing Date: 2025-03-07
Form Type: 424B7
Source: 0001193125-25-049889
Chunk: 11

Company: ARROWHEAD PHARMACEUTICALS, INC.
Filing Date: 2025-03-07
Form: 424B7
Chunk 11
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.gov. Our filings are also available, free of charge, on our website at www.arrowheadpharma.com. The information contained in, or that
can be accessed through, our website is not incorporated by reference herein and is not part of this prospectus supplement. The references to www.arrowheadpharma.comin this prospectus supplement or the documents incorporated by reference
herein are inactive textual references only. Investors should not rely on any such information in deciding whether to invest in our securities.

Statements contained in this prospectus supplement as to the contents of any contract or other document are not necessarily complete, and in each instance we
refer you to the copy of the contract or document filed as an exhibit to the registration statement, each such statement being qualified in all respects by such reference.

S-12

INCORPORATION OF CERTAIN INFORMATION BY REFERENCE The SEC allows us to incorporate by reference in this prospectus supplement the information that we file with it. Incorporation by reference means that we can disclose important information to you by referring you to other documents that are legally considered to be part of this prospectus supplement. Later information that we file with the SEC will automatically update and supersede the information in this prospectus supplement, any supplement and the documents listed below. We incorporate by reference the specific documents listed below and any future filings made with the SEC under Section 13(a), 13(c), 14, or 15(d) of the Exchange Act, as amended, until all of the Shares covered by this prospectus supplement are sold:

| • |     | the description of our common stock contained in our registration statement on Form                                                                      
 8-A/A (Registration No. 000-21898), filed on April 7, 2016, as the description therein has been updated and superseded by the description of our capital 
 stock contained in Exhibit 4.4 to our Annual Report on Form 10-K for                                                                                     
 the year ended September 30, 2024, including any amendments or reports filed for the purpose of updating such description.                               |

Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded, for purposes of this prospectus supplement, to the extent that a statement contained in or omitted from this prospectus supplement, or in any other subsequently filed document that also is or is deemed to be incorporated by reference herein, modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed,