Company: SHPH
Filing Date: 2025-11-18
Form Type: S-1
Source: 0001493152-25-024089
Chunk: 8

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-11-18
Form: S-1
Chunk 8
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 sale or other disposition of the shares of common stock covered by this prospectus. All proceeds from the sale of the shares will be paid directly to the selling stockholder.

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<div align='center'>SELLING STOCKHOLDER</div>

The shares of common stock being offered by the selling stockholder are those underlying the pre-funded warrant issued to the selling stockholder under the Purchase Agreement dated November 3, 2025 (see “Summary—Private Placement”). We are registering the shares of common stock in order to permit the selling stockholder to offer the shares for resale from time to time. Except for the ownership of the shares of common stock and as otherwise disclosed in this prospectus and as disclosed in this section under “Material Relationships with Selling Stockholder” below, the selling stockholder has not had any material relationship with us within the past three years. The selling stockholder is not a broker-dealer or an affiliate of a broker-dealer.

The table below lists the selling stockholder and other information regarding the beneficial ownership of the shares of common stock by the selling stockholder. The second column lists the number of shares of common stock beneficially owned by the selling stockholder, as of November 17, 2025. The third column lists the shares of common stock being offered by this prospectus by the selling stockholder.

In accordance with the terms of the Purchase Agreement, this prospectus covers the resale of the number of shares of common stock underlying a pre-funded warrant issued to the selling stockholder under the Purchase Agreement. The fourth column assumes the sale of all of the shares offered by the selling stockholder pursuant to this prospectus.

The selling stockholder may sell all, some or none of its shares in this offering. See “Plan of Distribution.”

| Selling Stockholder                    |     | Number of shares beneficially owned prior to offering(1) |         |    |     | Number of shares offered |         |     | Number                                         
 of shares beneficially owned after offering(2) |           |        |     | Percentage of shares beneficially owned after offering(3) |      |   |
| Alternative Investment Capital Inc.(4) |     |                                                          | 780,877 | -5 |     |                          | 625,156 |     |                                                | 1,406,033 | -5) (6 |     |                                                           | 47.1 | % |

(1) Under applicable SEC rules, a person is deemed to beneficially own securities which the person has the right