Company: PFSA
Filing Date: 2025-10-29
Form Type: 424B3
Source: 0001213900-25-103174
Chunk: 48

Company: Profusa, Inc.
Filing Date: 2025-10-29
Form: 424B3
Chunk 48
---
 failures, unscheduled downtimes, civil unrest, strikes, transportation interruptions,
unpermitted discharges or releases of toxic or hazardous substances, other environmental risks, sabotage or terrorist attacks, could severely
disrupt our operations, or our third-party manufacturers’ and suppliers’ operations, and have a material adverse effect on
our business, financial condition and results of operations.

If a natural disaster, power
outage or other event occurs that prevents us from using all or a significant portion of our headquarters or other facilities, or those
of our third-party manufacturers or suppliers, that damages critical infrastructure, such as our enterprise financial systems or manufacturing
resource planning and enterprise quality systems, or that otherwise disrupts operations, it may be difficult or, in certain cases, impossible,
for us to continue our business for a substantial period of time. A mechanical failure or disruption affecting any major operating line
may result in a disruption to our ability to supply customers, and standby capacity may not be available. The disaster recovery and business
continuity plans we have in place currently are limited and are unlikely to prove adequate in the event of a serious disaster or similar
event. The potential impact of any disruption would depend on the nature and extent of the damage caused by a disaster. There can be no
assurance that alternative production capacity will be available in the future in the event of a major disruption or, if it is available,
that it could be obtained on favorable terms. We may incur substantial expenses as a result of the limited nature of our disaster recovery
and business continuity plans, which, particularly when taken together with our lack of earthquake insurance, could have a material adverse
effect on our business, financial condition and results of operations.

<div align='center'>25</div>

Furthermore, integral parties
in our supply chain are similarly vulnerable to natural disasters or other sudden, unforeseen and severe adverse events. If such an event
were to affect our supply chain, it could have a material adverse effect on our business, financial condition and results of operations.

Our operating results may fluctuate significantly in the future, which makes our future operating results difficult to predict and could cause our operating results to fall below expectations or any guidance we may provide.

Our quarterly and annual operating
results may fluctuate significantly, which makes it difficult for us to predict our future operating results. These fluctuations may occur
due to a variety of factors, many of which are outside our control, including, but not limited to:

| ● | the timing and amount of expenditures that we