Company: NCNA
Filing Date: 2025-05-02
Form Type: F-1/A
Source: 0001193125-25-110310
Chunk: 107

Company: NuCana plc
Filing Date: 2025-05-02
Form: F-1/A
Chunk 107
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 other than as permitted under the Exchange Act, until it has completed its participation in the distribution.

Indemnification

We have agreed to
indemnify the Placement Agent against certain liabilities, including certain liabilities arising under the Securities Act and to contribute to payments that the Placement Agent may be required to make for these liabilities.

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Determination of Offering Price

The actual offering price of the securities we are offering has been negotiated between us and the investors in the offering based on the
trading of the ADSs prior to the offering, among other things. Other factors considered in determining the public offering price of the securities we are offering include our history and prospects, the stage of development of our business, our
business plans for the future and the extent to which they have been implemented, an assessment of our management, the general conditions of the securities markets at the time of the offering and such other factors as were deemed relevant.

Electronic Offer, Sale and Distribution of Securities

A prospectus in electronic format may be made available on the websites maintained by the Placement Agent, if any, participating in this
offering and the Placement Agent may distribute prospectuses electronically. Other than the prospectus in electronic format, the information on these websites is not part of this prospectus or the registration statement of which this prospectus
forms a part, has not been approved or endorsed by us or the Placement Agent, and should not be relied upon by investors.

Other Relationships

From time to time, the Placement Agent or its affiliates have in the past or may in the future provide in the future, various advisory,
investment and commercial banking and other services to us in the ordinary course of business, for which they have received and may continue to receive customary fees and commissions. However, except as disclosed in this prospectus, we have no
present arrangements with the Placement Agent for any further services.

Listing

The ADSs are listed on The Nasdaq Capital Market under the symbol “NCNA.”

Depositary

The depositary for the ADSs
is Citibank, N.A.

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EXPENSES We estimate that the expenses payable by us in connection with this offering, other than the Placement Agent discounts and commissions, will be as follows:

|                                 |     | Amount |         |
|:--------------------------------|:----|:-------|--------:|
| SEC registration fee            |     | $      |  11,942 |
| FINRA filing fee                |     |        |  12,200 |
| Printing and engraving