Company: PRTA
Filing Date: 2025-08-08
Form Type: S-8
Source: 0001559053-25-000034
Chunk: 6

Company: PROTHENA CORP PUBLIC LTD CO
Filing Date: 2025-08-08
Form: S-8
Chunk 6
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1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Brisbane, State of California, on this 8th of August, 2025.

| PROTHENA CORPORATION PLC |     |                                                 |
| By:                      |     | /s/ Gene G. Kinney                              |
|                          |     | Gene G. Kinney, Ph.D.                           
 President, Chief Executive Officer and Director |

POWER OF ATTORNEY Each person whose signature appears below constitutes and appoints Gene G. Kinney, Tran B. Nguyen and Michael J. Malecek, and each of them, as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including all post-effective amendments), and to file the same with all exhibits thereto, and other documents in connection therewith, with the Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each act and thing requisite and necessary to be done, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

| Signature                  
 /s/ Gene G. Kinney         |     | Title                                              
 President, Chief Executive Officer and Director    
 (Principal Executive Officer)                      |     | Date           
 August 8, 2025 |
|:---------------------------|:----|:---------------------------------------------------|:----|:---------------|
| Gene G. Kinney, Ph.D.      |     |                                                    |     |                |
| /s/ Tran B. Nguyen         |     | Chief Strategy Officer and Chief Financial Officer 
 (Principal Financial Officer)                      |     | August 8, 2025 |
| Tran B. Nguyen             |     |                                                    |     |                |
| /s/ Karin L. Walker        |