Company: SNY
Filing Date: 2025-10-27
Form Type: 424B5
Source: 0001193125-25-250786
Chunk: 97

Company: Sanofi
Filing Date: 2025-10-27
Form: 424B5
Chunk 97
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 declaration of acceleration.

We will furnish to the
trustee every year a written statement of certain of our officers certifying that, to their knowledge, we are in compliance with the indenture and the debt securities, or else specifying any default. (Section 1005)

Regarding the Trustee

We and several of
our subsidiaries may maintain banking relations with the trustee and its affiliates in the ordinary course of our and their business.

If
an event of default occurs, or an event occurs that would be an event of default if the requirements for giving us default notice under the indenture or our default having to continue for a specific period of time thereunder were disregarded, the
trustee may be considered to have a conflicting interest with respect to the debt securities or the applicable indenture for purposes of the Trust Indenture Act of 1939. In that case, the trustee may be required to resign as trustee under the
applicable indenture and we would be required to appoint a successor trustee. (Section 610)

21

LEGAL OWNERSHIP Street Name and Other Indirect Holders We generally will not recognize investors who hold securities in accounts at banks or brokers as legal Holders of securities. When we refer to the “Holders” of securities, we mean only the actual legal and (if applicable) record Holder of those securities. Holding securities in accounts at banks or brokers is called holding in “street name”. If you hold securities in street name, we will recognize only the bank or broker or the financial institution the bank or broker uses to hold its securities. These intermediary banks, brokers and other financial institutions pass along principal, interest, dividends and other payments on the securities, either because they agree to do so in their customer agreements or because they are legally required to do so. If you hold securities in street name, you should check with your own institution to find out:

| • |     | how it handles securities payments and notices; |

| • |     | whether it imposes fees or charges; |

| • |     | how it would handle voting rights if it were ever required; |

| • |     | how and when you should notify it to exercise on your behalf any rights or options that may exist under the debt 
 securities;                                                                                                      |

| • |     | whether and how you can instruct it to send you securities and, if the securities are in registered form, have 
 them registered in your own name, so you can be a direct Holder as described below; and                        |

| •