Company: APM
Filing Date: 2025-12-05
Form Type: 424B5
Source: 0001213900-25-118752
Chunk: 423

Company: Aptorum Group Ltd
Filing Date: 2025-12-05
Form: 424B5
Chunk 423
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 |       |     | $                               | - |     | $           | 133,207 |     |       |     | $         |   (776,791 | ) |

<div align='center'>243

UNAUDITED PRO FORMA CONDENSED COMBINED STATEMENT OF OPERATIONS
FOR THE YEAR ENDED DECEMBER 31, 2024
(In U.S. dollars except share and per share data)</div>

|                                                                              |     | Aptorum 12/31/2024 |            |   |     | DiamiR 2/28/2025 |            |   |     | Offering Transaction 
 accounting           
 adjustments          |          |   |     | Notes |     | Conversion of notes payable (c) |   |     | Acquisition Transaction 
 accounting              
 adjustments             |          |   |     | Notes |     | Pro Forma 
 Combined  |            |   |
|:-----------------------------------------------------------------------------|:----|:-------------------|-----------:|:--|:----|:-----------------|-----------:|:--|:----|:---------------------|:---------|:--|:----|:------|:----|:--------------------------------|:--|:----|:------------------------|---------:|:--|:----|:------|:----|:----------|-----------:|:--|
| Revenue                                                                      |     | $                  |          - |   |     | $                |    960,817 |   |     | $                    | -        |   |     |       |     | $                               | - |     | $                       |        - |   |     |       |     | $         |    960,817 |   |
| Operating expenses                                                           |     |                    |            |   |     |                  |            |   |     |                      |          |   |     |       |     |                                 |   |     |                         |          |   |     |       |     |           |            |   |
| Research and development expenses                                            |     |                    | (2,195,161 | ) |     |                  |   (831,600 | ) |     |                      | -        |   |     |       |     |                                 | - |     |                         |        - |   |     |       |     |           | (3,026,761 | ) |
| General and administrative fees                                              |     |                    | (1,745,380 | ) |     |