Company: RGNX
Filing Date: 2025-11-26
Form Type: S-3
Source: 0001193125-25-300539
Chunk: 27

Company: REGENXBIO Inc.
Filing Date: 2025-11-26
Form: S-3
Chunk 27
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, other than to increase such percentage or to provide that certain other provisions of the indenture cannot be modified except with the 
 consent of all affected holders;                                                                                                                                                                                                                    |

| • |     | change in any manner adverse to the interests of the holders the terms and conditions of the obligations of any                                                                                 
 guarantors in respect of the due and punctual payment of the principal thereof, premium, if any, and interest thereon, or any additional amounts or any sinking fund or analogous payments; and |

| • |     | impair the rights of holders with respect to any series of debt securities that are exchangeable or convertible 
 to receive payment or delivery of any consideration due upon the conversion or exchange.                        |

The holders of a majority in aggregate principal amount of all of the series of debt securities affected by a certain action, voting together as one class for this purpose, may amend or supplement the indenture or waive our compliance obligations with respect to some of our covenants in that indenture. However, we cannot obtain a waiver of a payment default or of any of the matters covered by the bullet points included above. Changes Not Requiring Approval Clarifications and certain other changes that would not adversely affect holders of the outstanding debt securities in any material respect, including the addition of covenants and guarantees, do not require any vote by the holders of outstanding debt securities. We also do not need to obtain any approval from holders to make any change that affects only debt securities to be issued under the indenture after the change takes effect or any changes that are required to comply with the requirements of the SEC or the Trust Indenture Act of 1939. Further Details Concerning Voting When taking a vote on proposed changes to the indenture and the debt securities, each holder will be entitled to one vote for each $1,000 in principal amount of the securities of such series. Debt securities will not be eligible to vote if they have been fully defeased as described under “Description of Debt Securities—Defeasance—Legal Defeasance.” We generally will be entitled to set any day as a record date for the purpose of determining the holders of outstanding debt securities that are entitled to vote or take other action under the indenture. Any record date must not be more than 90 calendar days nor less than 20 calendar days prior to the proposed date of such vote or action. Book-entry and other indirect holders will need to consult their banks or brokers for information on how approval may be granted or denied if we seek to change