Company: WSBC
Filing Date: 2025-09-11
Form Type: 424B5
Source: 0001193125-25-201360
Chunk: 2

Company: WESBANCO INC
Filing Date: 2025-09-11
Form: 424B5
Chunk 2
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 criminal offense.

|                                    |     | Per        
 Depositary 
 Share      |         |     | Total |             |
|:-----------------------------------|:----|:-----------|--------:|:----|:------|------------:|
| Public offering price(1)           |     | $          |   25.00 |     | $     | 230,000,000 |
| Underwriting discounts and         
 commissions(2)                     |     | $          |  0.5343 |     | $     |   4,915,675 |
| Proceeds to us, before expenses(2) |     | $          | 24.4657 |     | $     | 225,084,325 |

| (1) | The public offering price set forth above does not include dividends, if any, that may be declared. Dividends,  
 if declared, will be calculated from the date of original issuance, which is expected to be September 17, 2025. |

| (2) | Reflects 8,102,000 depository shares sold to institutional investors, for which the underwriters received an                                                                                                   
 underwriting discount of $0.5000 per depository share, and 1,098,000 depository shares sold to retail investors, for which the underwriters received an underwriting discount of $0.7875 per depository share. |

The underwriters expect to deliver the depositary shares in book-entry form through the facilities of The Depository Trust Company for the accounts of its participants, including Euroclear Bank S.A./N.A., as operator of the Euroclear System, and Clearstream Banking, Société Anonyme, against payment therefor in immediately available funds, on or about September 17, 2025, which is the fifth business day after the date hereof (such settlement being referred to as “T+5”). See “Underwriting” for details. Joint Book-Running Managers

| Keefe Bruyette & Woods |     | RBC Capital Markets |     | Raymond James |
| A Stifel Company       |     |                     |     |               |

Co-Manager D.A. Davidson & Co. The date of this prospectus supplement is September 10, 2025.

TABLE OF CONTENTS Prospectus Supplement

|                                                    |     | Page |      |
| ABOUT THIS PROSPECTUS SUPPLEMENT                   |     |      | S-1  |
| DISCLOSURE ABOUT