Company: RPTX
Filing Date: 2025-12-03
Form Type: PREM14A
Source: 0001193125-25-306948
Chunk: 41

Company: Repare Therapeutics Inc.
Filing Date: 2025-12-03
Form: PREM14A
Chunk 41
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 you must follow the instructions received from your broker, bank or other Intermediary to revoke your voting instructions.

| Q: | If I am a beneficial owner of Common Shares held in street name and I do not provide my broker or bank with 
 voting instructions, what happens?                                                                          |

| A: | If you are a beneficial owner of Common Shares held in street name and you do not instruct your broker, bank or                                                                                                                          
 other agent how to vote your Common Shares, the question of whether your broker or nominee will still be able to vote your Common Shares depends on whether, pursuant to stock exchange rules, the particular proposal is deemed to be a 
 “routine” matter. Brokers and nominees can use their discretion to vote “uninstructed” Common Shares with respect to matters that are considered to be “routine,” but not with respect                                                   
 to “non-routine” matters. Under applicable rules and interpretations, “non-routine” matters are matters that may substantially affect the rights or privileges of Shareholders, such as mergers, Shareholder                             
 proposals, elections of directors (even if not contested), executive compensation, and certain corporate governance proposals, even if management-supported. In this regard, Proposals 1 through 4 are considered to                     
 be “non-routine” under applicable rules, meaning your broker or nominee may not vote your Common Shares on Proposals 1 through 4 without your instructions. Such an event would result in a                                              
 “broker non-vote” and these Common Shares will not be counted as having been voted for such proposals.                                                                                                                                   |

20

If you are a beneficial owner of Common Shares held in street name, and you do not plan to attend the Special Meeting, in order to ensure your Common Shares are voted in the way you would prefer, you must provide voting instructions to your broker, bank or other agent by the deadline provided in the materials you receive from your broker, bank or other agent.

| Q: | What are “broker non-votes”? |

| A: | As discussed above, when a beneficial owner of Common Shares held in street name does not give voting                                                                                                                 
 instructions to the beneficial owner’s broker, bank or other securities intermediary holding such beneficial owner’s Common Shares as to how to vote on matters deemed to be “non-routine,” the broker, bank or other 
 such agent cannot vote the Common Shares. These un-voted Common Shares are counted as “broker non-votes.”                                                                                                             |

As a reminder, if you are a