Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 169

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 169
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 securities covered by this prospectus at a price that is substantially below the current trading price of such securities and may therefore make substantial profits upon resales.

The Selling Stockholder can sell, under this
prospectus, up to 6,685,714 shares of Common Stock representing approximately 49.7% of the shares of our Common Stock outstanding as of March 31, 2025, assuming the exercise of all outstanding Penny Warrants for which underlying shares are
registered for resale hereunder, which consists of (i) up to 6,500,000 shares of Common Stock issuable upon the exercise of currently exercisable Penny Warrants held by Oramed at an exercise price of $0.01 per share and (ii) up to 185,714
shares of Common Stock previously issued to Oramed upon the exercise of the Penny Warrants for 185,714 shares of Common Stock at an exercise price of $0.01 per share. The Selling Stockholder will be able to sell such shares registered for resale
hereunder for so long as the registration statement of which this prospectus forms a part is available for use and if applicable, upon exercise of the Penny Warrants.

The sale of all the securities being offered in this prospectus could result in a decline in the public trading price of our securities. Even
if the current trading price of our Common Stock is at or significantly below the price at which the Resale Shares were issued, the Selling Stockholder may have an incentive to sell because it will still profit on sales due to the lower price at
which they acquired their shares compared to the other securityholders. Other securityholders may not experience a similar rate of return on the securities they

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purchased due to differences in the purchase prices and the current trading price. For example, based on the closing price of our Common Stock of $5.43 on May 5, 2025, Oramed may experience
a potential profit of up to $5.42 per Resale Share given that the exercise price of the Penny Warrants is $0.01 per share. Depending on the price, the public securityholders may have paid significantly more than the Selling Stockholder for any
shares they may have purchased in the open market based on variable market prices and therefore may not be able to experience the same positive rates of return on securities they purchase.

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MARKET AND INDUSTRY DATA

Certain information contained in this prospectus relates to or is based on studies