Company: XXII
Filing Date: 2025-11-04
Form Type: 424B5
Source: 0001493152-25-020754
Chunk: 18

Company: 22nd Century Group, Inc.
Filing Date: 2025-11-04
Form: 424B5
Chunk 18
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 INC.              |  3 |
| USE                              
 OF PROCEEDS                      |  4 |
| DILUTION                         |  5 |
| SECURITIES                       
 TO BE OFFERED                    |  6 |
| DESCRIPTION                      
 OF DEBT SECURITIES               |  7 |
| DESCRIPTION                      
 OF CAPITAL STOCK                 | 13 |
| DESCRIPTION                      
 OF WARRANTS                      | 17 |
| DESCRIPTION                      
 OF SUBSCRIPTION RIGHTS           | 18 |
| DESCRIPTION                      
 OF SECURITIES PURCHASE CONTRACTS | 19 |
| DESCRIPTION                      
 OF UNITS                         | 20 |
| PLAN                             
 OF DISTRIBUTION                  | 21 |
| WHERE                            
 YOU CAN FIND MORE INFORMATION    | 23 |
| LEGAL                            
 MATTERS                          | 24 |
| EXPERTS                          | 24 |

| ii |

<div align='center'>ABOUT THIS PROSPECTUS</div>

Unless the context otherwise requires, references in this prospectus to “Company,” “22nd Century,” “we,” “us,” “our,” and “ours” refer to 22nd Century Group, Inc. and its subsidiaries where the context so requires.

This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission, or the SEC, using a “shelf” registration process. Under this shelf registration process, we may, from time to time, sell the securities described in this prospectus, in one or more offerings, up to the maximum aggregate dollar amount $250 million. This prospectus provides you with a general description of the securities that we may offer. Each time we offer securities, we will provide a prospectus supplement and/or other offering material that will contain specific information about the terms of that offering. The prospectus supplement and/or other offering material may also add, update or change information contained in this prospectus. You should read this prospectus and the applicable prospectus supplement and any other offering material together with the additional information described under the heading “Where You Can Find More Information.”

You should rely only on the information contained or incorporated by reference in this prospectus and in any prospectus supplement or other offering material. We have not authorized any other person to provide you with different information. If anyone provides you with different or inconsistent information, you should not rely on it. We are not making offers to sell the securities in any jurisdiction in which an offer is not authorized or in which the person making that offer is not qualified to do so or to anyone to whom it