Company: NCNA
Filing Date: 2025-06-30
Form Type: 6-K
Source: 0001193125-25-151990
Chunk: 0

Company: NuCana plc
Filing Date: 2025-06-30
Form: 6-K
Chunk 0
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### UNITED STATES

### SECURITIES
AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN ISSUER

PURSUANT TO RULE 13a-16 OR 15d-16

OF THE SECURITIES EXCHANGE ACT OF 1934

For the month of June 2025

(Commission File No. 001-38215)

### NUCANA PLC
(Translation of registrant’s name into English)

3 Lochside Way

Edinburgh EH12 9DT

United Kingdom

(Address of registrant’s principal executive office)

Indicate by check mark whether the registrant files or will file annual reports under
cover Form 20-F or Form 40-F.

Form 20-F ☒ Form 40-F ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101 (b) (1): ☐

Indicate by check mark if the registrant is
submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101 (b) (7): ☐

Sales Agreement

On June 27, 2025, NuCana plc (the “Company”) entered into a Sales Agreement (the “Agreement”) with A.G.P./Alliance Global Partners and
Laidlaw & Company (UK) Ltd. (together, the “Agents”), pursuant to which the Company may offer and sell, from time to time, through or to the Agents, as sales agents, American Depositary Shares (“ADSs”), each representing
25 ordinary shares, nominal value £0.0004 per share (the “ADSs”), up to an aggregate amount of $100 million.

The offer and sale of
the ADSs from time to time pursuant to the Agreement up to an aggregate amount of $100.0 million will be made pursuant to a shelf registration statement on Form F-3 and the related prospectus (File No. 333-281576), as amended (the “Registration Statement”), initially filed by the Company with the U.S. Securities and Exchange Commission (the “SEC”) on August 15, 2024, and amended
by a pre-effective amendment filed on June 18, 2025, and declared effective by the SEC on June 24, 2025, as supplemented by a prospectus supplement filed with the SEC pursuant to Rule 424(b)(