Company: PSTV
Filing Date: 2025-03-14
Form Type: PRE 14A
Source: 0001140361-25-008857
Chunk: 2

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-03-14
Form: PRE 14A
Chunk 2
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 proposals. Only stockholder of record as the close of business on March 4, 2025, will be entitled to notice of and to vote at the Special Meeting or any adjournment or postponement thereof. We are providing proxy material access to our stockholders via the Internet at [ ]. Please give the proxy materials your special attention.

TABLE OF CONTENTS

Your vote is very important. Even if you plan to attend the Special Meeting, we encourage all of our stockholders to review the proxy materials and vote your shares prior to the Special Meeting. Please submit your proxy as soon as possible via the Internet, telephone or mail. Submitting your proxy by one of these methods will ensure your vote will be counted regardless of whether you attend the Special Meeting.

| Via the Internet                                                               |     | By Phone                                                                   |     | By Mail                                                                                             |
| Visit the website listed on your notice, proxy card or voting instruction form |     | Call the phone number listed on your proxy card or voting instruction form |     | Complete, sign, date and return your proxy card or voting instruction form in the envelope provided |

| Plus Therapeutics, Inc.             |
| By order of the Board,              |
| Marc H. Hedrick                     |
| President & Chief Executive Officer |
| Houston, Texas, USA                 |
| March [ ], 2025                     |

TABLE OF CONTENTS

TABLE OF CONTENTS

|                                                                                            |     | Page |
| Information About the Special Meeting                                                      |     |    1 |
| Proposal 1: The Reverse Stock Split Proposal                                               |     |    7 |
| Proposal 2: The Issuance Proposal                                                          |     |   13 |
| Proposal 3: The Authorized Common Stock Increase Proposal                                  |     |   18 |
| Proposal 4: The Warrant Amendment Proposal                                                 |     |   20 |
| Proposal 5: The Adjournment Proposal                                                       |     |   22 |
| Stock Ownership Information                                                                |     |   23 |
| Annexes                                                                                    |     |      |
| Annex A: Certificate of Amendment to the Amended and Restated Certificate of Incorporation |     |  A-1 |
| Annex B: Certificate of Amendment to the Amended and Restated Certificate of Incorporation |     |  B-1 |

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#### TABLE OF CONTENTS

#### PLUS THERAPEUTICS, INC.

#### 2710 Reed Rd, Suite 160,

#### Houston, TX 77051

### PROXY