Company: CSTL
Filing Date: 2025-03-28
Form Type: PRE 14A
Source: 0001447362-25-000050
Chunk: 12

Company: CASTLE BIOSCIENCES INC
Filing Date: 2025-03-28
Form: PRE 14A
Chunk 12
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3)                             
 •Nominating and Corporate Governance Committee         |     |  51 |     |     2021 |
| Miles D. Harrison          |     | Yes         |     | •Compensation Committee (Chair)(3)                     
 •Nominating and Corporate Governance Committee         |     |  60 |     |     2020 |
| Tiffany P. Olson           |     | Yes         |     | •Audit Committee                                       
 •Nominating and Corporate Governance Committee (Chair) |     |  65 |     |     2021 |
| Class II Directors(4)      |     |             |     |                                                        |     |     |     |          |
| Daniel M. Bradbury (Chair) |     | Yes         |     | •None                                                  |     |  63 |     |     2012 |
| Rodney Cotton              |     | Yes         |     | •Audit Committee                                       
 •Compensation Committee                                |     |  65 |     |     2024 |

(1) Nominees for Election at the Annual Meeting.

(2) Continuing in Office until the 2026 Annual Meeting of Stockholders.

(3) Effective as of the closing of the Annual Meeting, Ms. Goldberg will replace Mr. Harrison as chair of the compensation committee.

(4) Continuing in Office until the 2027 Annual Meeting of Stockholders.

#### 18Castle Biosciences 2025 Proxy Statement
| Information Regarding the Board of Directors and Corporate Governance |

### EXPERIENCE AND ATTRIBUTES OF THE BOARD OF DIRECTORS
Our directors have a broad set of skills and experience that we believe facilitates strong oversight and provides strategic direction to our business.

Board Qualifications & Attributes Matrix (as of April [●], 2025) (1)

|                                                  |     | Ellen Goldberg |     | Miles D. Harrison |     | Tiffany P. Olson |     | Daniel M. Bradbury, Chair |     | Rodney Cotton |     | Kimberlee S. Caple |     | G. Bradley Cole |     | Derek J. Maetzold |
| Commercial Execution Experience                  |     | ●              |     | ●                 |     | ●                |     | ●                         |     | ●             |     |                    |     | ●               |     | ●                 |
| Life Science Industry Experience                 |     | ●              |     | ●                 |     | ●                |     | ●                         |     | ●             |     | ●                  |