Company: NCNA
Filing Date: 2025-05-02
Form Type: F-1/A
Source: 0001193125-25-110310
Chunk: 62

Company: NuCana plc
Filing Date: 2025-05-02
Form: F-1/A
Chunk 62
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 evidenced thereby. For transfers of ADRs, you will have to surrender the ADRs to be transferred to the depositary and also must:

| • |     | ensure that the surrendered ADR is properly endorsed or otherwise in proper form for transfer; |

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| • |     | provide such proof of identity and genuineness of signatures, and of such other matters contemplated in the 
 deposit agreement, as the depositary deems appropriate;                                                     |

| • |     | comply with applicable laws and regulations, including regulations imposed by us and the depositary consistent 
 with the deposit agreement, the ADR and applicable law;                                                        |

| • |     | provide any transfer stamps required by the State of New York or the United States; and |

| • |     | pay all applicable fees, charges, expenses, taxes and other government charges payable by ADR holders pursuant to 
 the terms of the deposit agreement, upon the transfer of ADRs.                                                    |

To have your ADRs either combined or split up, you must surrender the ADRs in question to the depositary with your request to have them combined or split up, and you must pay all applicable fees, charges and expenses payable by ADR holders, pursuant to the terms of the deposit agreement, upon a combination or split up of ADRs. Withdrawal of Ordinary Shares Upon Cancellation of ADSs As a holder, you will be entitled to present your ADSs to the depositary for cancellation and then receive the corresponding number of underlying ordinary shares at the custodian’s offices. Your ability to withdraw the ordinary shares held in respect of the ADSs may be limited by U.S. and England and Wales considerations applicable at the time of withdrawal. In order to withdraw the ordinary shares represented by your ADSs, you will be required to pay to the depositary the fees for cancellation of ADSs and any charges and taxes payable upon the transfer of the ordinary shares. You assume the risk for delivery of all funds and securities upon withdrawal. Once canceled, the ADSs will not have any rights under the deposit agreement. If you hold ADSs registered in your name, the depositary may ask you to provide proof of identity and genuineness of any signature and such other documents as the depositary may deem appropriate before it will cancel your ADSs. The withdrawal of the ordinary shares represented by your ADSs may be delayed until the depositary receives satisfactory evidence of compliance with all applicable laws and regulations. Please keep in mind that the depositary will only