Company: NOTV
Filing Date: 2025-03-13
Form Type: S-8
Source: 0001628280-25-012625
Chunk: 0

Company: Inotiv, Inc.
Filing Date: 2025-03-13
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on March 13, 2025.</div>

Registration No. 333-

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION
<div align='center'>Washington, D.C. 20549

____________________________________</div>

#### FORM S-8
<div align='center'>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

____________________________________</div>

#### INOTIV, INC.
<div align='center'>(Exact name of registrant as specified in its charter)</div>

| Indiana                         
 (State or other jurisdiction of 
 incorporation or organization)  |     | 35-1345024          
 (I.R.S. Employer    
 Identification No.) |

#### 2701 Kent Avenue

#### West Lafayette, Indiana 47906-1382
<div align='center'>(Address of Principal Executive Offices) (Zip Code)</div>

#### Inotiv, Inc. 2024 Equity Incentive Plan
<div align='center'>(Full title of the plan)</div>

#### Beth A. Taylor

### Chief Financial Officer

#### Inotiv, Inc.

#### 2701 Kent Avenue

#### West Lafayette, Indiana 47906-1382
<div align='center'>(765) 463-4527

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copy to:</div>

#### Christine G. Long

#### Griffin D. Foster

#### Faegre Drinker Biddle & Reath LLP

#### 600 E. 96

#### th

#### Street, Suite 600

#### Indianapolis, Indiana 46240
<div align='center'>(317) 569-9600</div>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated fileroNon-accelerated filero |     | Accelerated filerxSmaller Reporting CompanyoEmerging growth companyo |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial