Company: FITBI
Filing Date: 2025-11-05
Form Type: S-4
Source: 0001193125-25-267273
Chunk: 8

Company: FIFTH THIRD BANCORP
Filing Date: 2025-11-05
Form: S-4
Chunk 8
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 holders, the “Fifth Third common shareholders”) and holders of Fifth Third 6.00% Non-CumulativePerpetual Class B Preferred Stock, Series A (“Fifth Third preferred stock,”) or depositary shares in respect thereof (such holders, the “Fifth Third voting preferred shareholders” and together with the Fifth Third common shareholders, the “Fifth Third voting shareholders”) will be held virtually via the Internet on January 6, 2026 at 9:00 a.m., Eastern Standard Time at www.virtualshareholdermeeting.com/FITB2026SM . We are pleased to notify you of and invite you to the Fifth Third special meeting. At the Fifth Third special meeting you will be asked to vote on the following matters:

| • |     | A proposal to approve the issuance of Fifth Third common stock in connection with the merger of Comerica with and                                                                                                                                     
 into Fifth Third Intermediary as merger consideration to holders of Comerica common stock pursuant to the merger agreement, (including for purposes of complying with NASDAQ Rule 5635(d), which requires approval of the issuance of shares of Fifth 
 Third common stock in an amount that exceeds 20% of the currently outstanding shares of Fifth Third common stock) (the “Fifth Third stock issuance proposal”); and                                                                                    |

| • |     | A proposal to adjourn the Fifth Third special meeting, if necessary or appropriate, to solicit additional proxies                                                                                                                                     
 if, immediately prior to such adjournment, there are not sufficient votes to approve the Fifth Third stock issuance proposal or to ensure that any supplement or amendment to the accompanying joint proxy statement/prospectus is timely provided to 
 Fifth Third shareholders (the “Fifth Third adjournment proposal”).                                                                                                                                                                                    |

The Fifth Third special meeting will be held in a virtual-only format conducted via live webcast. In order to attend the Fifth Third special meeting via remote communication, you must access the virtual meeting at www.virtualshareholdermeeting.com/FITB2026SM. You also will need a control number, which is the 16-digitnumber on your proxy card. Once admitted to the Fifth Third special meeting, you will be able to vote your shares in accordance with the instructions provided on the meeting website. The board of directors of Fifth Third has fixed the close of business on November 24, 2025 as the record date for the Fifth Third special meeting. Only holders of record of Fifth Third common stock and Fifth Third voting preferred stock as of the close of business on the record