Company: PSTV
Filing Date: 2025-06-18
Form Type: S-1
Source: 0001193125-25-142215
Chunk: 3

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-06-18
Form: S-1
Chunk 3
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 documents incorporated by reference in this prospectus, and in any applicable prospectus supplement, before investing in these securities.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is , 2025

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS                                                               |     | ii |
| PROSPECTUS SUMMARY                                                                  |     |  1 |
| THE OFFERING                                                                        |     |  2 |
| FORWARD-LOOKING STATEMENTS                                                          |     |  6 |
| THE LINCOLN PARK TRANSACTION                                                        |     |  7 |
| USE OF PROCEEDS                                                                     |     | 13 |
| DILUTION                                                                            |     | 14 |
| THE SELLING STOCKHOLDER                                                             |     | 15 |
| MARKET PRICE OF OUR COMMON STOCK AND RELATED STOCKHOLDER                            
 MATTERS                                                                             |     | 17 |
| DESCRIPTION OF CAPITAL STOCK                                                        |     | 18 |
| PLAN OF DISTRIBUTION                                                                |     | 23 |
| LEGAL MATTERS                                                                       |     | 25 |
| EXPERTS                                                                             |     | 25 |
| WHERE YOU CAN FIND MORE INFORMATION                                                 |     | 25 |
| INCORPORATION BY REFERENCE                                                          |     | 26 |
| DISCLOSURE OF COMMISSION POSITION ON INDEMNIFICATION FOR SECURITIES ACT LIABILITIES |     | 27 |

i

ABOUT THIS PROSPECTUS

This prospectus forms part of a registration statement that we filed with the Securities and Exchange Commission (the “SEC”), and
that includes exhibits that provide more detail of the matters discussed in this prospectus. You should read this prospectus and the related exhibits filed with the SEC, together with the additional information described under the headings
“Where You Can Find More Information” and “Incorporation by Reference” before making your investment decision.

You
should rely only on the information provided in this prospectus or in a prospectus supplement or any free writing prospectuses or amendments thereto. Neither we, nor the selling stockholder, have authorized anyone else to provide you with different
information. If anyone provides you with different or inconsistent information, you should not rely on it. You should assume that the information in this prospectus is accurate only as of the date hereof. Our business, financial condition, results
of operations and prospects may