Company: OSRH
Filing Date: 2025-01-29
Form Type: S-4/A
Source: 0001213900-25-007923
Chunk: 423

Company: OSR Holdings, Inc.
Filing Date: 2025-01-29
Form: S-4/A
Chunk 423
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 support for device delivery        |
| Synchro wire                          |     | Stryker           |     | Neurovascular guide wire              |     | Navigation through neurovascular anatomy                    |
| Traxcess wire                         |     | Microvention      |     | Neurovascular guide wire              |     | Navigation through neurovascular anatomy                    |
| Envoy guide catheter                  |     | Cerenovous        |     | Neurovascular guide catheter          |     | Support and delivery of neurointerventional devices         |
| Guider soft tip guide catheter        |     | Boston scientific |     | Soft tip neurovascular Guide catheter |     | Support and delivery of neurointerventional devices         |
| Microplex coil system                 |     | Microvention      |     | Detachable embolization coil system   |     | Embolization of intracranial aneurysms                      |
| GDC coil system                       |     | Stryker           |     | Detachable Coil system                |     | Embolization of intracranial aneurysms                      |
| Axium prime coil system               |     | Medtronic         |     | Detachable Coil system                |     | Embolization of intracranial aneurysms                      |

Manufacturing We do not have any manufacturing facilities or personnel at this time, except that Darnatein maintains and uses manufacturing facilities owned by Joint Center for Biosciences, Darnatein’s affiliate and OSR Holdings’ shareholder, for purposes of R&D and clinical and preclinical materials for its sole use. We currently rely on CMOs for the manufacture of our product candidates for preclinical and clinical testing in non -commercialquantities.

267 Our product candidates include small molecules, vaccines, and monoclonal and bispecific antibodies. Several contract manufacturing facilities exist that have expertise in each product type and we anticipate that our product candidates can be produced by them at scale and in a cost -effectivemanner. As needed, we also expect to rely on CMOs for the manufacturing of companion diagnostics, which are assays or tests to identify an appropriate patient population. Depending on the technology solutions we choose, we may rely on multiple third parties to manufacture and sell a single test. Vaximm has a master service agreement with Richter -HelmBioLogics GmbH & Co. KG (“RHB”), a CMO located in Germany, for the manufacture of Vaximm’s product candidates. RHB will provide cell line development,