Company: NCNA
Filing Date: 2025-06-18
Form Type: F-3/A
Source: 0001193125-25-142565
Chunk: 0

Company: NuCana plc
Filing Date: 2025-06-18
Form: F-3/A
Chunk 0
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As filed with the Securities and Exchange Commission on June 18, 2025 Registration No. 333-281576 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Pre-EffectiveAmendment No. 1 to Form F-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NUCANA PLC (Exact name of registrant as specified in its charter) Not Applicable (Translation of registrant’s name into English)

| England and Wales               |     | Not Applicable        |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -I.R.S. Employer      
 Identification Number |

NuCana plc 3 Lochside Way Edinburgh, EH12 9DT United Kingdom Telephone: +44 (0)131 357 1111 (Address and telephone number of registrant’s principal executive offices) Corporation Service Company 251 Little Falls Drive, Wilmington, DE 19808 United States Telephone: +1 302 636 5400 (Name, address, and telephone number of agent for service) Copies to: William C. Hicks, Esq. John T. Rudy, Esq. Allyson Wilkinson, Esq. Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. One Financial Center Boston, MA 02111 Telephone: +1 617 542 6000 Facsimile: +1 617 542 2241 APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:From time to time after the effective date of this registration statement. If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐ If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. ☒ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.