Company: ERAS
Filing Date: 2025-08-12
Form Type: S-3
Source: 0001193125-25-179038
Chunk: 39

Company: Erasca, Inc.
Filing Date: 2025-08-12
Form: S-3
Chunk 39
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, we may otherwise loan or pledge securities to a financial institution or other third party that in turn may
sell the securities short using this prospectus and an applicable prospectus supplement. Such financial institution or other third party may transfer its economic short position to investors in our securities or in connection with a concurrent
offering of other securities.

The specific terms of any lock-up provisions in respect of any given offering will
be described in the applicable prospectus supplement.

The underwriters, dealers and agents may engage in transactions with us, or perform services for
us, in the ordinary course of business for which they receive compensation.

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LEGAL MATTERS

Latham & Watkins LLP, San Diego, California, will pass upon certain legal matters relating to the issuance and sale of the securities offered hereby
on behalf of Erasca, Inc. Latham & Watkins LLP and certain attorneys in the firm who have rendered, and will continue to render, legal services to us, own shares of our common stock representing in the aggregate less than one percent of the
shares of our common stock outstanding. Additional legal matters may be passed upon for us or any underwriters, dealers or agents, by counsel that we will name in the applicable prospectus supplement.

EXPERTS

The
consolidated financial statements of Erasca, Inc. as of December 31, 2024 and 2023, and for the years then ended, have been incorporated by reference herein and in the registration statement in reliance upon the report of KPMG LLP, independent
registered public accounting firm, incorporated by reference herein, and upon the authority of said firm as experts in accounting and auditing.

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The information in this preliminary prospectus is not complete and may be changed. These securities may not be sold until the registration statement filed with the Securities and Exchange Commission is effective. This preliminary prospectus is not an offer to sell nor does it seek an offer to buy these securities in any jurisdiction where the offer or sale is not permitted.

Subject to Completion, dated August 12, 2025.

PROSPECTUS

Up to $200,000,000

Common Stock

We have entered into an Amended and Restated Open Market Sale Agreement (the Sale Agreement) with
Jefferies LLC (Jefferies) relating to the sale of shares of our common stock, par value $0.0001 per share, offered by this prospectus. In accordance with the terms of such Sale Agreement, pursuant to this prospectus, we may offer and sell