Company: SHPH
Filing Date: 2025-03-31
Form Type: DEF 14A
Source: 0001641172-25-001889
Chunk: 35

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-03-31
Form: DEF 14A
Chunk 35
---
.’s 2018 Equity Incentive Plan to increase the amount of shares reserved for issuance by 5,000,000 shares of common stock.

| What                                  
 am I voting on and how should I vote? |     | You                                                                                                                              
 are being asked to approve the first amendment to Shuttle Pharmaceuticals Holdings, Inc.’s 2018 Equity Incentive Plan to         
 increase the amount of shares reserved for issuance by 5,000,000 shares of common stock. The Board of Directors believes that    
 increase the number of shares reserved under the Company’s 2018 Equity Incentive Plan is in the best interest of the Company     
 and its stockholders as it will allow for the issuance of additional equity incentive awards to the Company’s employees,         
 directors and consultants.                                                                                                       
 The                                                                                                                              
 Board of Directors therefore recommends you vote “FOR” the approval of the first amendment to Shuttle Pharmaceuticals            
 Holdings, Inc.’s 2018 Equity Incentive Plan to increase the amount of shares reserved for issuance by 5,000,000 shares of common 
 stock.                                                                                                                           |

We are seeking stockholder approval of the first
amendment (the “First Amendment”) to the Company’s 2018 Plan to increase the amount of shares reserved for issuance
under the 2018 Plan by 5,000,000 shares. The 2018 Plan provides eligible officers, directors, key employees and other key individuals
an incentive to contribute to the success of the Company and to operate and manage our business in a manner that provides for the Company’s
long-term growth and profitability and provides a means of obtaining, rewarding and retaining key personnel. In the judgment of the Board
of Directors, awards under the 2018 Plan are a valuable incentive that serves to the ultimate benefit of stockholders by aligning more
closely the interests of 2018 Plan participants with those of our stockholders.

The Board of Directors have approved the First
Amendment, subject to and effective upon approval from the Company’s stockholders at the 2025 Annual Meeting.

To date, there have been 1,173,675 shares
of our common stock granted under the 2018 Plan, of which 796,925 remain subject to vesting and, at present, there are 679,434
shares remaining available for issuance under the 2018 Plan. Accordingly, we are asking our stockholders to approve the First Amendment to
increase the number of shares of our common stock reserved for issuance under