Company: PSTV
Filing Date: 2025-04-23
Form Type: S-3/A
Source: 0001193125-25-091456
Chunk: 5

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-23
Form: S-3/A
Chunk 5
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 prospectus supplement is accurate as of any date other than the date of the applicable document. Since the date of this prospectus and the documents filed as exhibits to the registration statement of which this prospectus forms a part, our business, financial condition, results of operations and prospects may have changed. i

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement that we filed with the Securities and Exchange Commission (the “SEC”) using a “shelf”
registration process. Under this shelf registration process, the selling stockholders identified in this prospectus under the section entitled “Selling Stockholders,” may use the shelf registration statement to offer and resell, from time
to time, up to an aggregate of 1,565,044,860 shares of our common stock through any means described in the section entitled “Plan of Distribution”.

A prospectus supplement may also add, update or change information included in this prospectus. Any statement contained in this prospectus will be deemed to
be modified or superseded for purposes of this prospectus to the extent that a statement contained in such prospectus supplement modifies or supersedes such statement. Any statement so modified will be deemed to constitute a part of this prospectus
only as so modified, and any statement so superseded will be deemed not to constitute a part of this prospectus. You should rely only on the information contained in this prospectus, any applicable prospectus supplement or any related free writing
prospectus, including any information incorporated by reference. See “Where You Can Find More Information” and “Information Incorporated by Reference.”

We are not selling any shares of common stock under this prospectus, and we will not receive any proceeds from the sale of shares of common stock offered
hereby by the selling stockholders, although we may receive cash from the exercise of the Warrants (as defined in this prospectus).

You should rely only
on the information provided in this prospectus, including any information incorporated by reference. We have not authorized anyone to provide you with any other information and we take no responsibility for, and can provide no assurances as to the
reliability of, any other information that others may give you. The information contained in this prospectus speaks only as of the date set forth on the cover page and may not reflect subsequent changes in our business, financial condition, results
of operations and prospects.

Neither we nor the selling stockholders have authorized anyone to provide any information or to make any representations
other than those contained in this