Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 28

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 28
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 any amount withheld against your United States federal income tax liability. You generally may obtain a refund of any amounts withheld under the backup withholding rules that exceed your income tax liability by filing a refund claim with the IRS.

<div align='center'>S-21</div>

### UNDERWRITING
J.P. Morgan Securities LLC and SMBC Nikko Securities America, Inc. are acting as representatives of each of the underwriters named below. Subject to the terms and conditions set forth in an underwriting agreement among us and the underwriters, we have agreed to sell to the underwriters, and each of the underwriters has agreed, severally and not jointly, to purchase from us, the principal amount of each series of the Notes set forth opposite its name below.

| Underwriters                        |     | Principal amount of 2035 Notes |               |     | Principal amount of 2055 Notes |             |
|:------------------------------------|:----|:-------------------------------|--------------:|:----|:-------------------------------|------------:|
| J.P. Morgan Securities LLC          |     | $                              |   412,500,000 |     | $                              | 187,500,000 |
| SMBC Nikko Securities America, Inc. |     |                                |   412,500,000 |     |                                | 187,500,000 |
| BNP Paribas                         |     |                                |   107,250,000 |     |                                |  48,750,000 |
| BofA Securities, Inc.               |     |                                |   107,250,000 |     |                                |  48,750,000 |
| HSBC Securities (USA) Inc.          |     |                                |   107,250,000 |     |                                |  48,750,000 |
| Morgan Stanley & Co. LLC            |     |                                |   107,250,000 |     |                                |  48,750,000 |
| Barclays Capital Inc.               |     |                                |    66,000,000 |     |                                |  30,000,000 |
| Citigroup Global Markets Inc.       |     |                                |    66,000,000 |     |                                |  30,000,000 |
| Commerz Markets LLC                 |     |                                |    66,000,000 |     |                                |  30,000,000 |
| Goldman Sachs & Co.