Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 479

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 479
---
isable for an aggregate of 72,352 shares of Common Stock remain outstanding.

The foregoing
summaries of the terms and conditions of the November 2025 Warrants do not purport to be complete and are qualified in their entirety by reference to the copies of the forms of November 2025 Investor Warrant and November 2025 Placement Agent Warrant
that are filed as an exhibit to the registration statement of which this prospectus forms a part. See the section titled “Description of the November 2025 Warrants” for more detailed information about the November 2025 Warrants.

Transfer Agent and Registrar

The
transfer agent and registrar for our Common Stock is Continental. The transfer agent’s address is 1 State Street, 30th Floor, New York, New York 10004.

Listing

Shares of our Common Stock and
Public Warrants are listed on the Nasdaq Capital Market under the symbols “SCLX” and “SCLXW”, respectively.

310

LEGAL MATTERS

The validity of the securities being offered by this prospectus will be passed upon for us by Paul Hastings LLP, Palo Alto, California.

EXPERTS

The consolidated financial statements of Scilex Holding Company as of December 31, 2024 and December 31, 2023, and for each of the
two years in the period ended December 31, 2024, appearing in this prospectus, have been audited by BPM LLP, independent registered public accounting firm, as set forth in their report thereon (which contains an explanatory paragraph describing
conditions that raise substantial doubt about the Company’s ability to continue as a going concern as described in Note 2 to the consolidated financial statements) appearing elsewhere herein, and are included in reliance upon such report
given on the authority of such firm as experts in accounting and auditing.

WHERE YOU CAN FIND MORE INFORMATION

We have filed a registration statement on Form S-1, including exhibits,
under the Securities Act, with respect to the securities offered by this prospectus. This prospectus does not contain all of the information included in the registration statement. For further information pertaining to us and our securities, you
should refer to the registration statement of which this prospectus is a part and the exhibits to such registration statement. The descriptions in this prospectus of the provisions of documents filed as exhibits to this prospectus are only summaries
of those documents’ material terms. You can read copies of such documents, along with copies of reports, proxy statements and other information