Company: DRTSW
Filing Date: 2025-03-12
Form Type: 20-F
Source: 0001213900-25-023187
Chunk: 148

Company: Alpha Tau Medical Ltd.
Filing Date: 2025-03-12
Form: 20-F
Item: Item 4
Chunk 148
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 led to better tumor control than either therapy alone or the standard of care chemotherapy
gemcitabine.

This result was further explored
in a pre-clinical study that examined the growth of untreated distant pancreatic cancer tumor models in mice. When mice were inoculated
intracutaneously with two pancreatic cancer model tumors (from the KPC or Panc02 tumor models) and treated with Alpha DaRT sources instead
of inert sources in one pancreatic cancer tumor, a statistically significant decline in secondary tumor growth rate was seen, as can be
seen in the figure below. This was true for both the KPC and Panc02 models independently.

Components of the Alpha DaRT ®

Alpha DaRT technology is delivered
in a kit comprising radioactive stainless steel or titanium hollow wires or tubes of 5-10 mm length and <1mm diameter, known as “sources,”
and applicators to administer the sources. Each source is impregnated with Radium-224, which generates the decay chain of alpha emitters
that are designed to recoil into the tumor. These proprietary applicators have been specially designed and developed by us for dispensing
the sources based upon the tumor’s location in the body in order to facilitate clinicians’ access to hard-to-reach tumors
or tumors which are extremely close to major organs or blood vessels. We believe the applicators are a key component to maximizing the
potential advantages of localized alpha radiotherapy.

Our Alpha DaRT kit comprises
three main components: the radioactive source, specialized applicators, and accessories. We have developed the applicators and accessories
with input from clinicians across a variety of specialties in an effort to optimize the Alpha DaRT technology for clinical use.

Our Alpha DaRT Sources

Our Alpha DaRT sources utilize
a hollow tube or rod, made of either stainless steel or titanium, to which Radium-224 is affixed. Titanium is our preferred material of
choice for use in internal organs, especially those that may require enhanced MRI compatibility, such as the brain. Our Alpha DaRT sources
are designed to be customized to multiple sizes (depending on their intended use) and designed as temporary implants (for use in and removal
from superficial tumors) or permanent implants (for use in internal organs). Our R& D department is constantly examining enhancements
to future versions of the Alpha DaRT sources, including the use of additional materials that we believe could offer advantages in flexibility,
biocompatibility or biodegradability, more advanced anchoring and fixation, or enhanced properties of des