Company: HURA
Filing Date: 2025-11-03
Form Type: S-3
Source: 0001193125-25-262843
Chunk: 4

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-11-03
Form: S-3
Chunk 4
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 Common Stock in a number of different ways and at varying prices. We provide more information about how the selling stockholders may sell the shares of
Common Stock in the section of this prospectus titled “Plan of Distribution - Selling Stockholders Plan of Distribution.” We will not receive any of the proceeds from the sale of our Common Stock by the selling stockholders. We have paid
or will pay the fees and expenses incident to the registration of the shares of Common Stock for sale by the selling stockholders. The selling stockholders will bear all discounts, concessions, commissions and stock transfer taxes, if any,
attributable to their sales of shares.

This prospectus describes the general manner in which our securities may be offered using this
prospectus. We will provide specific terms of the securities, including the offering prices, in one or more supplements to this prospectus. The supplements may also add, update, or change information contained in this prospectus. You should read
this prospectus and the prospectus supplement relating to the specific issue of securities carefully before you invest.

We or the selling
stockholders may offer the securities independently or together in any combination for sale directly to purchasers or through underwriters, dealers, or agents to be designated at a future date. The supplements to this prospectus will provide the
specific terms of the plan of distribution for securities to be offered by us or by the selling stockholders.

Our common stock, par value
$0.001 per share (“Common Stock”), is traded on the Nasdaq Capital Market under the symbol “HURA.” On October 30, 2025, the last reported sales price of our Common Stock was $2.48 per share.

Investment in our securities involves risks. Please read carefully the section entitled “ Risk Factors” in our most recent Annual Report on Form 10-Kand in any applicable prospectus supplement and/or other offering material for a discussion of certain factors which should be considered in an investment of the securities which may be offered hereby.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is , 2025.

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS                                |     |  1 |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |  2 |
| TUHURA BIOSCIENCES, INC.                             |     |