Company: MTB-PJ
Filing Date: 2025-10-30
Form Type: 424B5
Source: 0001193125-25-257002
Chunk: 73

Company: M&T BANK CORP
Filing Date: 2025-10-30
Form: 424B5
Chunk 73
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 supplement, and for any underwriters or agents by counsel selected by such underwriters or agents identified in the applicable prospectus supplement or, if necessary, the applicable pricing supplement.

EXPERTS

The financial statements and management’s assessment of the effectiveness of internal control over financial reporting (which is
included in Management’s Report on Internal Control over Financial Reporting) incorporated in this prospectus by reference to the Annual Report on Form 10-K of M&T Bank Corporation for the year ended
December 31, 2022 have been so incorporated in reliance on the report (which contains a paragraph relating to the effectiveness of internal control over financial reporting due to the exclusion of certain elements of People’s United
Financial, Inc. because it was acquired by M&T in a purchase business combination during 2022) of PricewaterhouseCoopers LLP, an independent registered public accounting firm, given on the authority of said firm as experts in auditing and
accounting.

The consolidated financial statements of People’s United as of December 31, 2021 and 2020, and for each of the
years in the three-year period ended December 31, 2021, have been incorporated by reference herein and in the registration statement in reliance upon the report of KPMG LLP, independent registered public accounting firm, incorporated by
reference herein, and upon the authority of said firm as experts in accounting and auditing.

5

18,000,000 Depositary Shares Each Representing a 1/400th Interest in a Share of Perpetual 6.350% Non-Cumulative PreferredStock, Series K PROSPECTUS SUPPLEMENT October 28, 2025 Joint Bookrunners

| RBC Capital Markets |     | BofA Securities |     | Morgan Stanley |     | M&T Securities |     | UBS Investment Bank |     | Wells Fargo Securities |

Co Managers

| Loop Capital Markets |     | R. Seelaus & Co., LLC |     | Raymond James |