Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063906
Chunk: 5

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 5
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 Merger Agreement, pursuant to which he agreed to vote in favor of the Proposals. After careful consideration, each of the Aptorum and DiamiR boards of directors has approved the Merger Agreement and the transactions contemplated by the Merger Agreement and have determined that it is advisable to consummate the Merger. The Aptorum board of directors has approved the Proposals and recommends that its shareholders vote “FOR” the proposals described in the accompanying proxy statement/prospectus. YOUR VOTE IS IMPORTANT. Aptorum requests that you sign and return the enclosed proxy or vote by mail or online to ensure that your shares will be represented at the Special Meeting if you are unable to attend. You may change or revoke your proxy at any time before it is voted at the Special Meeting. More information about Aptorum, DiamiR, the Merger Agreement and transactions contemplated thereby and the foregoing proposals is contained in the accompanying proxy statement / prospectus. Aptorum urges you to read the accompanying proxy statement / prospectus carefully and in its entirety. IN PARTICULAR, YOU SHOULD CAREFULLY CONSIDER THE MATTERS DISCUSSED UNDER “ RISK FACTORS ”. Aptorum and DiamiR are excited about the opportunities the Merger brings to Aptorum and DiamiR stockholders and thank you for your consideration and continued support. Sincerely,

| Ian Huen                |     | Alidad Mireskandari      |
| Chief Executive Officer |     | Chief Executive Officer  |
| Aptorum Group Limited   |     | DiamiR Biosciences Corp. |

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the Merger, the issuance of Aptorum securities in connection with the Merger or the other transactions described in the accompanying proxy statement / prospectus or passed upon the adequacy or accuracy of the accompanying proxy statement / prospectus. Any representation to the contrary is a criminal offense. The accompanying proxy statement / prospectus is dated , 2025, and is first being mailed to Aptorum stockholders on or about , 2025.

APTORUM GROUP LIMITED
SPECIAL MEETING OF SHAREHOLDERS
TO BE HELD ON [ ] 2025
NOTICE OF SPECIAL MEETING OF STOCKHOLDERS To the shareholders of Aptorum: NOTICE IS HEREBY GIVENthat an in -personspecial meeting of shareholders of Aptorum Group Limited (the “Special Meeting”), will be held on [ ], 2025, at [9:30 a.m. Eastern