Company: NYXH
Filing Date: 2025-03-20
Form Type: F-3
Source: 0001104659-25-026217
Chunk: 56

Company: Nyxoah SA
Filing Date: 2025-03-20
Form: F-3
Chunk 56
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 a part of this prospectus. We have included our website address in this prospectus solely as an inactive textual reference.

You should rely only on information contained in, or incorporated by reference into, this prospectus. We have not authorized anyone to provide you with information different from that contained in this prospectus or incorporated by reference in this prospectus. We are not making offers to sell the securities in any jurisdiction in which such an offer or solicitation is not authorized or in which the person making such offer or solicitation is not qualified to do so or to anyone to whom it is unlawful to make such offer or solicitation.

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TABLE OF CONTENTS

**The information in this preliminary prospectus supplement is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This preliminary prospectus supplement is not an offer to sell these securities and it is not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.**

<div align='center'>SUBJECT TO COMPLETION, DATED MARCH 20, 2025</div>

**PROSPECTUS SUPPLEMENT (To prospectus dated , 2025)**

#### Nyxoah SA

#### Up to $50,000,000Ordinary Shares
**We have entered into a sales agreement, or the Sales Agreement, with Cantor Fitzgerald & Co., or Cantor, relating to the sale of our ordinary shares offered by this prospectus supplement. In accordance with the terms of the Sales Agreement, we may offer and sell our ordinary shares having an aggregate offering price of up to $50.0 million from time to time through Cantor acting as our agent.

Our ordinary shares are listed on The Nasdaq Global Market under the symbol “NYXH”. On March 19, 2025, the last reported sale price of our ordinary shares was $11.33 per ordinary share.

Sales of our ordinary shares, if any, under this prospectus supplement will be made in sales deemed to be “at the market offerings” as defined in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended, or the Securities Act. Cantor is not required to sell any specific amount of securities, but will act as our sales agent using commercially reasonable efforts consistent with its normal trading and sales practices, on mutually agreed terms between Cantor and us.

The compensation to Cantor