Company: NCNA
Filing Date: 2025-11-05
Form Type: 6-K
Source: 0001193125-25-265824
Chunk: 1

Company: NuCana plc
Filing Date: 2025-11-05
Form: 6-K
Chunk 1
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 or the Exchange Act, except as otherwise set forth herein or as shall be expressly set forth by specific reference in such a filing.

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

| NuCana plc |     |                                            |
| By:        |     | /s/ Ian Webster                            |
| Name:      |     | Ian Webster                                |
| Title:     |     | Interim Chief Financial Officer (Principal 
 Financial and Accounting Officer)          |

Date: November 5, 2025