Company: RCUS
Filing Date: 2025-02-18
Form Type: 424B5
Source: 0001193125-25-028669
Chunk: 47

Company: Arcus Biosciences, Inc.
Filing Date: 2025-02-18
Form: 424B5
Chunk 47
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ational products;                                                   |

| • |     | our ability to obtain and maintain regulatory approvals of our investigational products and the potential market 
 opportunities for commercializing our investigational products;                                                  |

| • |     | our ability to retain and recruit key personnel, estimates of our expenses, future revenue, capital requirements 
 and our needs for additional financing;                                                                          |

| • |     | our ability to develop, acquire and advance investigational products into, and successfully complete, clinical 
 trials;                                                                                                        |

| • |     | our initiation, timing, progress and results of future research and development programs, preclinical studies and 
 clinical trials;                                                                                                  |

| • |     | our ability to obtain and maintain intellectual property rights covering our investigational products; |

| • |     | our expectations regarding the developments and projections relating to our competitors; |

| • |     | our expectations as to the effect that the COVID-19 pandemic will have on our company; and |

| • |     | our expectations regarding our industry. |

In some cases, you can identify forward-looking statements by terms such as “may,” “will,” “should,” “could,” “would,” “expects,” “plans,” “anticipates,” “believes,” “estimates,” “projects,” “predicts,” “potential” and similar expressions intended to identify forward-looking statements. These statements reflect our current views with respect to future events and are based on assumptions and are subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. We discuss in greater detail many of these risks under the heading “Risk Factors” contained in the applicable prospectus supplement, in any free writing prospectuses we may authorize for use in connection with a specific offering, and 7

in our most recent Annual Report on Form 10-K and in our most recent Quarterly Report on Form 10-Q, as well as any amendments thereto reflected in subsequent filings with the SEC, which are
incorporated by reference into this prospectus in their entirety. Also, these forward-looking statements represent our estimates and assumptions only as of the date of the document containing the applicable statement. Unless required by law, we
undertake no obligation to update or revise any forward-looking statements to reflect new information or future events or developments. Thus, you should not assume that our silence over time means that actual events are bearing out as expressed or
implied in such forward-looking statements. You should read this prospectus, any applicable prospect