Company: RGNX
Filing Date: 2025-06-13
Form Type: S-8
Source: 0000950170-25-086259
Chunk: 1

Company: REGENXBIO Inc.
Filing Date: 2025-06-13
Form: S-8
Chunk 1
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)(2)(B) of the Securities Act. 

<div align='center'>PART I</div>

The information required by Item 1 and Item 2 of this Part I of Form S-8 is omitted from this Registration Statement on Form S-8 (this “Registration Statement”) in accordance with Rule 428 under the Securities Act of 1933, as amended (the “Securities Act”), and the introductory note to Part I of Form S-8. REGENXBIO Inc. (the “Company”) will deliver the documents containing the information specified in Part I to the participants in the REGENXBIO Inc. 2025 Equity Incentive Plan as required by Rule 428(b)(1) under the Securities Act.

<div align='center'>PART II

Information Required in the Registration Statement</div>

Item 3. Incorporation of Documents by Reference.

We file annual, quarterly and current reports, proxy statements, and other information with the United States Securities and Exchange Commission (the “SEC”). Our filings with the SEC are available on the SEC’s website atwww.sec.govand on our website atwww.regenxbio.comas soon as reasonably practicable after we file such material with, or furnish it to, the SEC. However, the information on our website is not incorporated by reference herein, and is not a part of this prospectus, any prospectus supplement or any of our other filings with the SEC.

The following documents (File No. 001-37553) previously filed with the SEC are hereby incorporated by reference:

our Annual Report on Form 10-K for the year ended December 31, 2024 , filed with the SEC on March 13, 2025 (the “2024 Annual Report”);

our Quarterly Report on Form 10-Q for the quarter ended March 31, 2025 , filed with the SEC on May 12, 2025;

our Current Reports on Form 8-K filed with the SEC on January 14, 2025 (Item 1.01 only), March 4, 2025 (Item 8.01 only), May 19, 2025 (Items 1.01 and 2.03 only) and June 3, 2025 ; and

the description of our common stock contained in Exhibit 4.2 to our Annual Report on Form 10-K for the year ended December 31, 2024 , filed with the SEC on March 13, 202