Company: SHPH
Filing Date: 2025-03-05
Form Type: S-1/A
Source: 0001493152-25-009106
Chunk: 63

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-03-05
Form: S-1/A
Chunk 63
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 combination to include the following:

| ● | any                                                                                                                                
 merger or consolidation involving the corporation and the interested stockholder;                                                  |
| ● | any                                                                                                                                
 sale, transfer, pledge, or other disposition of 10% or more of the assets of the corporation involving the interested stockholder; |
| ● | subject                                                                                                                            
 to certain exceptions, any transaction that results in the issuance or transfer by the corporation of any stock of the corporation 
 to the interested stockholder;                                                                                                     |

| 39 |

| ● | any                                                                                                                                 
 transaction involving the corporation that has the effect of increasing the proportionate share of the stock or any class or series 
 of the corporation beneficially owned by the interested stockholder; or                                                             |
| ● | the                                                                                                                                 
 receipt by the interested stockholder of the benefit of any loss, advances, guarantees, pledges or other financial benefits by or   
 through the corporation.                                                                                                            |

Section 203 defines interested stockholder as an entity or person beneficially owning 15% or more of the outstanding voting stock of the corporation or any entity or person affiliated with or controlling or controlled by such entity or person.

By-Laws

The Company recently amended and restated its by-laws (the “Third Amended and Restated By-Laws”) to lower the quorum requirement for calling a meeting of stockholders from a majority of shares outstanding to one-third or share outstanding. No other changes were made when adopting the Third Amended and Restated By-Laws.

Nasdaq Listing

Our shares of common stock are traded on The Nasdaq Capital Market under the symbol “SHPH.” We do not intend to apply for the listing of the Pre-Funded Warrants on any national securities exchange or other nationally recognized trading system.

Transfer Agent

The transfer agent and registrar of our common stock is VStock Transfer, LLC, of Woodmere, New York. Our transfer agent’s telephone number is (212) 828-8436.

<div align='center'>DESCRIPTION OF SECURITIES WE ARE OFFERING</div>

We are offering, on a firm commitment underwritten basis up to 10,000,000 shares of common stock, or Pre-Funded Warrants in lieu thereof.

Common Stock

The material terms and provisions of our common stock are described under the caption “Description of Capital Stock” in this prospectus.

| 40 |

Pre-Funded Warrants

The following summary of certain terms and provisions of the Pre-Funded Warrants that are being offered hereby is not complete and is