Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 9

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 9
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| • |     | catastrophic events may adversely affect the general economy, financial and capital markets, specific industries, 
 and the Company;                                                                                                  |

| • |     | climate change manifesting as physical or transition risks could adversely affect the Company’s operations, 
 businesses and customers;                                                                                   |

| • |     | changes in accounting standards could materially impact the Company’s financial statements; |

| • |     | the Company’s accounting policies and processes are critical to the reporting of financial condition and 
 results of operations and require management to make estimates about matters that are uncertain;         |

| • |     | the Company’s stock price can be volatile; and |

| • |     | an investment in the Company’s equity securities is not insured or guaranteed by the FDIC. |

Comerica cautions that the foregoing list of factors is not all-inclusive.For discussion of factors that may cause actual results to differ from expectations, please refer to our filings with the SEC. In particular, please refer to “Item 1A. Risk Factors” beginning on page 16 of Comerica’s Annual Report on Form 10-Kfor the year ended S-v

December 31, 2024. Forward-looking statements speak only as of the date they are made. Comerica does not undertake to update forward-looking statements to reflect facts, circumstances,
assumptions or events that occur after the date the forward-looking statements are made. For any forward-looking statements made in this prospectus supplement and the accompanying prospectus, including the documents incorporated by reference,
Comerica claims the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995.

S-vi

SUMMARY The following summary should be read together with the information contained in other parts of this prospectus supplement and the accompanying prospectus, including the documents we incorporate by reference. This summary highlights selected information from this prospectus supplement, the accompanying prospectus and the documents incorporated by reference to help you understand the offering of the depositary shares. You should read this prospectus supplement and the accompanying prospectus carefully to understand fully the terms of the depositary shares and the Series B Preferred Stock represented thereby as well as the other considerations that are important to you in making a decision about whether to invest in the depositary shares. You should pay special attention to the “Risk Factors” section beginning on page S-12of this prospectus supplement and the information set forth under the caption “Risk Factors” in our Annual Report on