Company: PRME
Filing Date: 2025-11-07
Form Type: S-3ASR
Source: 0001628280-25-050428
Chunk: 73

Company: Prime Medicine, Inc.
Filing Date: 2025-11-07
Form: S-3ASR
Chunk 73
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<div align='center'>S-14</div>

#### Up to $200,000,000

#### Common Stock

### PROSPECTUS

#### Jefferies

#### November 7, 2025

# PART II

### INFORMATION NOT REQUIRED IN PROSPECTUS

## Item 14. Other Expenses of Issuance and Distribution.
The expenses payable by Prime Medicine, Inc. (the “Registrant” “we,” “our,” “us” or the “Company”) in connection with the issuance and distribution of the securities being registered (other than underwriting discounts and commissions, if any) are set forth below. Each item listed is estimated, except for the Securities and Exchange Commission (“SEC”) registration fee.

| SEC registration fee            |     |   | -1 |
| Legal fees and expenses         |     |   | -2 |
| Accounting fees and expenses    |     |   | -2 |
| Printing fees and expenses      |     |   | -2 |
| Transfer agent and trustee fees |     |   | -2 |
| Miscellaneous                   |     |   | -2 |
| Total                           |     | $ | -2 |

_____________

(1) Pursuant to Rule 456(b) and Rule 457(r) under the Securities Act of 1933, as amended (the “Securities Act”), the SEC registration fee will be paid at the time of any particular offering of securities under the registration statement other than the fees due in connection with the $200,000,000 of our common stock that may be issued and sold from time to time under an Open Market Sale AgreementSM with Jefferies LLC.

(2) These fees and expenses are calculated based on the number of issuances and the amount of securities offered and accordingly cannot be estimated at this time.

## Item 15. Indemnification of Directors and Officers.
Section 145 of the Delaware General Corporation Law (the “DGCL”) authorizes a corporation to indemnify its directors and officers against liabilities arising out of actions, suits and proceedings to which they are made or threatened to be made a party by reason of the fact that they have served or are currently serving as a director or officer to a corporation. The indemnity may cover expenses (including attorneys’ fees) judgments, fines and amounts paid in settlement actually and reasonably incurred by the director or officer in connection with any such action, suit or proceeding if the director or officer acted in good faith and in a manner the director or officer reasonably