Company: QTIWW
Filing Date: 2025-01-16
Form Type: S-1
Source: 0001628280-25-001723
Chunk: 198

Company: QT IMAGING HOLDINGS, INC.
Filing Date: 2025-01-16
Form: S-1
Chunk 198
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 A.I.-Based Mass Diagnostics                                                                     |     | Reduce unnecessary procedures (biopsies, additional imaging) by identifying lesion type                                                                                                                                                        |     | Short term    |
| Screening for High-Risk Young Women                                                             |     | Provide young women a safe, comfortable, accurate method to screen for breast cancer                                                                                                                                                           |     | Medium term   |
| Alternative to Screening Mammography                                                            |     | Provide all women a safe, comfortable, accurate method to screen for breast cancer                                                                                                                                                             |     | Long term     |
|                                                                                                 |     | Table 1                                                                                                                                                                                                                                        |     |               |

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* Note: the foregoing is based on the Company’s current estimates and the timeframe is subject to change due to various factors, including those described in the “Risk Factors” section and elsewhere in this registration statement/prospectus.

Breast Scanner Clinical Images

The images below (Image 5 and Image 6) compare an artist’s depiction of the normal breast anatomic features (top) and QTscan® images rendered by the QT Breast Scanner of a normal human breast (below) showing the skin, fat, breast duct and glandular (terminal) units of the living breast. The Cooper’s ligaments, ducts, and glandular structures are not visible in conventional breast screening imaging.

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Schematic anatomy of the breast

Image 5</div>

Transmission (left) and reflection tomograms of the breast. The white and black squares in the speed of sound image (left) mark fat and glandular tissue, respectively. Single and double black arrows mark ductal tissue and skin, respectively. Reflection image (right): Single white arrows mark the connective tissue identified as Cooper’s ligaments.

<div align='center'>Image 6</div>

Two key metrics in breast imaging are sensitivity and specificity. Mammography has well-recognized challenges with sensitivity in dense breasts. Image 7 below compares the same breast across different imaging

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modalities. In addition to demonstrating differences in image quality across modalities, it represents a case where a mass was not visible on mammography but is visible on the MRI and QTscan.

<div align='center'>Image 7</div>

The Company recently conducted a mini study looking specifically at the ability of its technology to identify masses in dense breasts compared to mammography. Forty cases were selected in which there was a finding on the QTscan. The cases were selected from a “Case Collection Study to Determine