Company: JPC
Filing Date: 2025-06-12
Form Type: 424B3
Source: 0001999371-25-007638
Chunk: 193

Company: Nuveen Preferred & Income Opportunities Fund
Filing Date: 2025-06-12
Form: 424B3
Chunk 193
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|       | Authorized Signatures ─ This section must be completed for your vote to be counted.─ Sign and Date Below |
| Note: | Please                                                                                                   
 sign exactly as your name(s) appear(s) on this proxy card, and date it. When shares are held             
 jointly, each holder should sign. When signing as attorney, executor, administrator, trustee,            
 guardian, officer of corporation or other entity or in another representative capacity, please           
 give the full title under the signature.                                                                 |

| Date (mm/dd/yyyy) ─ Please print 
 date below                       |     | Signature 1 ─ Please keep signature 
 within the box                      |     | Signature 2 ─ Please keep signature 
 within the box                      |
| /      /                         |     |                                     |     |                                     |

| Scanner  
 bar code |

| xxxxxxxxxxxxxx | JPC 34517 | xxxxxxxx |

<div align='center'>STATEMENT OF ADDITIONAL INFORMATION

RELATING TO THE MERGER OF

NUVEEN PREFERRED SECURITIES & INCOME OPPORTUNITIES FUND (JPI)AND
NUVEEN PREFERRED & INCOME OPPORTUNITIES FUND (JPC)
(EACH, A “FUND” AND COLLECTIVELY, THE “FUNDS”)</div>

This Statement of Additional Information (“SAI”) is available to common shareholders of Nuveen Preferred Securities & Income Opportunities Fund (the “Target Fund”) and preferred shareholders of Nuveen Preferred & Income Opportunities Fund (the “Acquiring Fund” and together with the Target Fund, the “Funds” or each individually, a “Fund”), in connection with the proposed merger of the Target Fund with and into a wholly-owned subsidiary of the Acquiring Fund. With respect to the merger, the Agreement and Plan of Merger provides for: (i) the merger of the Target Fund with and into JPI Merger Sub, LLC, a Massachusetts limited liability company and a wholly-owned subsidiary of the Acquiring Fund, and (ii) the conversion of the issued and outstanding common shares of beneficial interest of the Target Fund into newly issued common shares of beneficial interest, par value $0.01 per share, of the Acquiring Fund (the “Merger”).

This SAI is not a prospectus and should be read in conjunction with the Joint Proxy Statement/Prospectus dated June 11, 2025 and filed on Form N-14 with the Securities and Exchange Commission (“SEC”) relating to