Company: RGNT
Filing Date: 2025-05-19
Form Type: F-1/A
Source: 0001213900-25-045479
Chunk: 128

Company: REGENTIS BIOMATERIALS LTD.
Filing Date: 2025-05-19
Form: F-1/A
Chunk 128
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 mature into
actual granted patents. Thus, there is a risk that if any one or more family members are not granted, the improved compositions will
not be patent protected in their respective territory.

GelrinV and GelrinP

A second “pipeline
product” of the Company is designated as GelrinV and it is a product using a conjugate of fibrinogen with a polaxamer (Pluronic)
for the treatment of osteoarthritis. The product exhibits thermo-reversible gelation, is water-immiscible and can be delivered using
a minimally invasive application. It is designed to a form of a paste in the cavity upon UVA irradiation.

This product is more viscous
and better suited for the intended purpose of providing relief from chronic conditions including osteoarthritis. This second potential
product is described by the third family of patents derived from WO 2011/07399, which was filed December 16, 2010. Patents from this family
are nominally due to expire in December 2030 and include patents Nos. US 8,846,020, EP 2513294, CN 102762715 and IL 220343, which are
detailed in the table below.

GelrinP derived from WO
2014/207749 filed June 24, 2014 claims an injectable curable paste that can be shaped to fill defects requiring treatment. The family
of patent applications derived from WO 2014/207749 includes patents Nos. US 10,434,215, EP 3013377 and CN 105407933, which are detailed
in the table below.

A patent derived from
WO 2008/126092, patent No. US 9,624,259, that was filed April 16, 2008, claims conjugates of the serum protein albumin with PEG.
This patent may be useful to supplement the protection of GelrinC which may contain albumin as well as fibrinogen.

Patents derived from or related to WO 2015/052708 filed on January 24, 2014 claim an apparatus or method for treatment of cavities in a human body. The patent applications derived include patents Nos. US 9,895,519, US 9,872,705, EP 2874546(validated in Germany,
France and the United Kingdom), CN 106232023 and IL 235270, which are detailed