Company: WSBC
Filing Date: 2025-09-11
Form Type: 424B5
Source: 0001193125-25-201360
Chunk: 23

Company: WESBANCO INC
Filing Date: 2025-09-11
Form: 424B5
Chunk 23
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 the Series B Preferred Stock. There can be no assurance about the market prices for the depositary shares representing interests in the Series B Preferred Stock. Several factors, many of which are beyond our control, will influence the market value of the depositary shares. Factors that might influence the market value of the depositary shares include:

| • |     | whether we skip or are likely to skip dividends on the Series B Preferred Stock from time to time; |

| • |     | our creditworthiness, regulatory capital levels, operating performance, financial condition and prospects; |

| • |     | the ratings of our securities provided by credit ratings agencies, including ratings on the Series B Preferred 
 Stock and related depositary shares;                                                                           |

| • |     | our issuance of additional preferred equity; |

| • |     | interest rates, generally, and expectations regarding changes in rates; |

S-16

| • |     | developments in the credit, mortgage and housing markets, the markets for securities relating to mortgages or 
 housing, and developments with respect to financial institutions generally;                                   |

| • |     | the market for similar bank holding company securities; and |

| • |     | economic, financial, geopolitical, regulatory or judicial events that affect us or the financial markets 
 generally.                                                                                               |

Accordingly, the depositary shares that an investor purchases, whether in the offering or in the secondary market, may trade at a discount to their cost, and their value will fluctuate. Additional issuances of preferred stock or securities convertible into preferred stock may further dilute existing holders of the depositary shares. We may determine that it is advisable, or we may encounter circumstances where we determine it is necessary, to issue additional shares of preferred stock, securities convertible into, exchangeable for, or that represent an interest in preferred stock, or preferred stock-equivalent securities to fund strategic initiatives or other business needs or to build additional capital. Our board of directors is authorized to cause us to issue one or more classes or series of preferred stock from time to time without any action on the part of our shareholders, including issuing additional shares of Series B Preferred Stock or additional depositary shares. Our board of directors also has the power, without shareholder approval, to set the terms of any such classes or series of preferred stock that may be issued, including voting rights, dividend rights, and preferences over the Series B Preferred Stock with respect to dividends or upon our dissolution, liquidation or winding-upand other terms. Although the affirmative vote or consent of the holders