Company: SPRB
Filing Date: 2025-06-12
Form Type: DEFA14A
Source: 0000950170-25-085137
Chunk: 0

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-06-12
Form: DEFA14A
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<div align='center'>SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the
Securities Exchange Act of 1934
(Amendment No. )</div>

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Filed by a Party other than the Registrant ☐

Check the appropriate box:

☐Preliminary Proxy Statement

☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

☐Definitive Proxy Statement

☒Definitive Additional Materials

☐ Soliciting Material Pursuant to §240.14a-12

<div align='center'>Spruce Biosciences, Inc.(Name of Registrant as Specified In Its Charter)

N/A

(Name of Person(s) Filing Proxy Statement if Other Than the Registrant)</div>

Payment of Filing Fee (Check the appropriate box):

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☐ Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

<div align='center'>1

On June 12, 2025, Spruce Biosciences, Inc. issued the following press release.

Spruce Biosciences Announces Conditional Nasdaq Approval to Resume Trading on the Nasdaq Capital Market

Relisting Contingent Upon Stockholder Approval of Reverse Stock Split

Trading on Nasdaq Capital Market Anticipated to Commence On or Before August 5, 2025</div>

SOUTH SAN FRANCISCO, Calif.– June 12, 2025–Spruce Biosciences, Inc. (OTC: SPRB) (“Spruce”), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, announced that it has received approval from The Nasdaq Stock Market LLC (“Nasdaq”) to resume trading of its common stock on the Nasdaq Capital Market subject to Spruce regaining compliance with Nasdaq’s minimum bid price requirement on or before August 5, 2025.

“We are pleased by Nasdaq’s decision to lift its trading suspension and resume trading of our common stock on or before August 5, 2025, subject to our compliance with the minimum bid price requirement,” said Samir Gharib, President and Chief Financial Officer of Spruce. “We are