Company: TEM
Filing Date: 2025-08-08
Form Type: S-3ASR
Source: 0001193125-25-175993
Chunk: 78

Company: Tempus AI, Inc.
Filing Date: 2025-08-08
Form: S-3ASR
Chunk 78
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 sales are made, or on some other date that is agreed upon by us and the sales agents in connection with a particular transaction, in return for payment of the net proceeds to us. There is no arrangement for funds to be received in an escrow,
trust or similar arrangement.

8

In connection with the sale of the Class A common stock on our behalf, each sales agent
may be deemed to be an underwriter within the meaning of the Securities Act, and its compensation as sales agent may be deemed to be underwriting commissions or discounts.

The offering pursuant to the sales agreement will terminate upon the termination of the sales agreement as permitted therein. We and each of
the sales agents have the right to terminate the sales agreement at any time upon two days’ prior written notice.

Each of Morgan
Stanley, Cantor, TD Securities and Allen and their respective affiliates have in the past and may in the future provide various investment banking, commercial banking, financial advisory and other financial services for us and our affiliates, for
which services they may in the future receive customary fees and reimbursement for expenses.

In the course of its business, the sales
agents may actively trade our securities for their own accounts or for the accounts of clients, and, accordingly, the sales agents may at any time hold long or short positions in such securities. The sales agents may also communicate independent
investment recommendations, market color or trading ideas and/or publish or express independent research views in respect of such securities or instruments and may at any time hold, or recommend to clients that they acquire, long and/or short
positions in such securities and instruments.

This summary of the material provisions of the sales agreement does not purport to be a
complete statement of its terms and conditions.

9

LEGAL MATTERS

Certain legal matters in connection with the offering and the validity of the securities offered by this prospectus, will be passed upon by
Cooley LLP, Chicago, Illinois and, with respect to matters of Nevada law, by Brownstein Hyatt Farber Schreck, LLP, Las Vegas, Nevada. Certain legal matters in connection with this offering will be passed upon for the sales agents by Davis
Polk & Wardwell LLP, Redwood City, California.

EXPERTS

The financial statements incorporated in this Prospectus by reference to the Annual Report on Form
10-K for the year ended December 31, 2024 have been so incorporated in reliance on the report of PricewaterhouseCoopers LLP, an independent registered public accounting firm, given on the