Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 0

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 0
---
As filed with the Securities and Exchange Commission on April 29, 2025. Registration No. 333-286716 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NUCANA PLC (Exact name of registrant as specified in its charter) Not Applicable (Translation of Registrant’s name into English)

| England and Wales               |     |                         2834 |     | Not Applicable        |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -Primary Standard Industrial 
   Classification Code Number |     | -I.R.S. Employer      
 Identification Number |

NuCana plc 3 Lochside Way Edinburgh, EH12 9DT United Kingdom Telephone: +44 (0)131 357 1111 (Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices) Corporation Service Company 251 Little Falls Drive Wilmington, DE 19808 United States Telephone: +1 302 421 6100 (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies to:

| William C. Hicks, Esq.                                  
 John T. Rudy, Esq. Allyson                              
 Wilkinson, Esq. Mintz, Levin, Cohn, Ferris, Glovsky and 
 Popeo, P.C. One Financial                               
 Center Boston, MA 02111                                 
 Telephone: +1 617 542 6000                              
 Facsimile: +1 617 542 2241                              |     | Hugh S. Griffith          
 Chief Executive Officer   
 NuCana plc 3 Lochside     
 Way Edinburgh, EH12 9DT   
 United Kingdom Telephone: 
 +44 (0)131 357 1111       |     | David Danovitch, Esq.      
 Aaron Schleicher, Esq.     
 Sullivan & Worcester LLP   
 1251 6th Avenue            
 New York, NY 10020         
 Telephone: +1 212 660 3000 
 Facsimile: +1 212 819 8000 |

Approximate date of commencement of proposed sale to the public:As soon as practicable after the effective date of this registration statement. If any of the securities being registered on this form are to be offered on a delayed or continuous basis pursuant to