Company: NCNA
Filing Date: 2025-04-24
Form Type: F-1
Source: 0001193125-25-092131
Chunk: 16

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-1
Chunk 16
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 in this offering, the number of Series A Warrants sold in this offering will not change as a result of a change in the mix of the ADSs and           
 Pre-Funded Warrants sold.                                                                                                                                                    |

5

| To better understand the terms of the Series A Warrants, including the cashless exercise option, you should carefully read the “Description of Securities We Are Offering” section of this prospectus. |

| Series B Warrants offered by us | Each ADS and each Pre-Funded Warrant to purchase one ADS is being sold together with a Series B Warrant to purchase one ADS. Each Series B Warrant will have an exercise price equal to 125% of the combined 
 public offering price, will be exercisable at any time beginning on the Initial Exercise Date and will expire on the two and one-half (2.5)-year anniversary of the Initial Exercise Date.                   |

| This prospectus also relates to the offering of the ADSs issuable upon exercise of the Series B Warrants. Because we will issue a Series B Warrant for each ADS and for each 
 Pre-Funded Warrant sold in this offering, the number of Series B Warrants sold in this offering will not change as a result of a change in the mix of the ADSs and           
 Pre-Funded Warrants sold.                                                                                                                                                    |

| To better understand the terms of the Series B Warrants, including the cashless exercise option and “zero exercise price” option, you should carefully read the “Description of Securities We Are 
 Offering” section of this prospectus.                                                                                                                                                             |

| ADSs outstanding prior to this offering | 5,737,172 ADSs, each representing twenty-five ordinary shares. |

| ADSs outstanding after this offering | 21,786,555 ADSs, each representing twenty-five ordinary shares. |

| Ordinary shares to be outstanding immediately after this offering | 553,129,349 ordinary shares (including those ordinary shares represented by ADSs). |

| ADSs | Each ADS represents twenty-five ordinary shares, nominal value £0.0004 per ordinary share. |

| The depositary or its custodian, or a nominee of either, will hold the ordinary shares underlying your ADSs. As an ADS holder you will not be treated as one of our shareholders and you will not have shareholder rights.                        
 You will have rights as provided in the deposit agreement, as amended, or the deposit agreement. You may cancel your ADSs and withdraw the underlying ordinary shares as provided in the deposit agreement.