Company: IOBT
Filing Date: 2025-04-25
Form Type: DEF 14A
Source: 0000950170-25-058699
Chunk: 1

Company: IO Biotech, Inc.
Filing Date: 2025-04-25
Form: DEF 14A
Chunk 1
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 2025; and

the transaction of such other business as may properly come before the meeting, or any adjournment or postponement thereof.

Stockholders of record at the close of business on April 11, 2025 are entitled to notice of, and to vote at, the annual meeting and any adjournment or postponement thereof. All stockholders are cordially invited to attend the meeting.

<div align='center'>YOUR VOTE IS IMPORTANT.</div>

You may cast your vote over the Internet, by telephone, or by completing and mailing a proxy card. Returning the proxy does not deprive you of your right to attend the annual meeting and to vote your shares during the meeting. Proxies forwarded by or for banks, brokers or other nominees should be returned as requested by them. We encourage you to vote promptly to ensure your vote is represented at the annual meeting, regardless of whether you plan to attend.

You can find detailed information regarding voting in the section entitled “General Information” on pages 6 through 9 of the accompanying proxy statement.

<div align='center'>IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS
FOR THE ANNUAL MEETING OF STOCKHOLDERS TO BE HELD ON JUNE 5, 2025

The notice of the annual meeting, proxy statement and the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2024 are available atwww.proxydocs.com/IOBT.

You will be asked to enter the control number located on your proxy card or Notice of Internet Availability of Proxy Materials to access the Company’s materials and vote throughwww.proxydocs.com/IOBT.</div>

| BY ORDER OF THE BOARD OF DIRECTORS                     |
| Sincerely,                                             |
| Devin SmithGeneral Counsel andSecretary of the Company |

Copenhagen, Denmark – April 25, 2025

TABLE OF CONTENTS

| GENERAL INFORMATION                                                                                                                                                                   |     |  1 |
| PROPOSAL ONE: ELECTION OF CLASS I DIRECTOR                                                                                                                                            |     |  6 |
| General                                                                                                                                                                               |     |  6 |
| Information Regarding Nominees and Continuing Directors                                                                                                                               |     |  6 |
| Recommendation of Our Board of Directors                                                                                                                                              |     |  7 |
| CORPORATE GOVERNANCE                                                                                                                                                                  |     | 10 |
| Director Independence                                                                                                                                                                 |     | 10 |
| Leadership Structure of the Board of Directors                                                                                                                                        |     | 10 |
| Board