Company: SRPT
Filing Date: 2025-08-06
Form Type: S-8
Source: 0001193125-25-174466
Chunk: 1

Company: Sarepta Therapeutics, Inc.
Filing Date: 2025-08-06
Form: S-8
Chunk 1
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EXPLANATORY NOTE This Registration Statement on Form S-8(this “Registration Statement”) is being filed to register an additional 4,300,000 shares of the Registrant’s common stock, par value $0.0001 per share (“Common Stock”), for issuance under the 2018 Equity Incentive Plan, as amended, and an additional 300,000 shares of Common Stock for issuance under the Registrant’s Amended and Restated 2013 Employee Stock Purchase Plan (as amended and restated on June 27, 2016), as amended. This Registration Statement is being filed in accordance with General Instruction E to Form S-8regarding registration of additional securities of the same class, and, pursuant to such instruction, the contents of the Registration Statement on Form S-8( File No. 333-213002) filed with the Securities and Exchange Commission on August 9, 2016, the contents of the Registration Statement on Form S-8( File No. 333-228719) filed with the Securities and Exchange Commission on December 7, 2018, the contents of the Registration Statement on Form S-8( File No. 333-233715) filed with the Securities and Exchange Commission on September 11, 2019, the contents of the Registration Statement on Form S-8( File No. 333-240996) filed with the Securities and Exchange Commission on August 5, 2020, the contents of the Registration Statement on Form S-8( File No. 333-266461) filed with the Securities and Exchange Commission on August 2, 2022, the contents of the Registration Form on S-8( File No. 333-273608) filed with the Securities and Exchange Commission on August 2, 2023, the content of the Post-Effective Amendment to Registration Statement on Form S-8( File No. 333-240996) filed with the Securities and Exchange Commission on March 28, 2024, and the content of the Post-Effective Amendment to Registration Statement on Form S-8( File No. 333-228719) filed with the Securities and Exchange Commission on March 28, 2024 are each incorporated herein by reference. Item 8. Exhibits

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