Company: HRTX
Filing Date: 2025-09-09
Form Type: S-3
Source: 0000950170-25-113834
Chunk: 3

Company: HERON THERAPEUTICS, INC. /DE/
Filing Date: 2025-09-09
Form: S-3
Chunk 3
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 About this Prospectus                             |     |   ii |
| Forward-looking Statements                        |     |    1 |
| Prospectus Summary                                |     |    4 |
| Risk Factors                                      |     |   14 |
| Use of Proceeds                                   |     |   15 |
| Description of the Securities We May Offer        |     |   16 |
| Description of Capital Stock                      |     |   17 |
| Description of Debt Securities                    |     |   21 |
| Description of Warrants                           |     |   22 |
| Description of Rights                             |     |   23 |
| Description of Units                              |     |   24 |
| Legal Ownership of Securities                     |     |   25 |
| Plan of Distribution                              |     |   29 |
| Where You Can Find More Information               |     |   31 |
| Incorporation of Certain Information by Reference |     |   32 |
| Legal Matters                                     |     |   33 |
| Experts                                           |     |   33 |

<div align='center'>i

ABOUT THIS PROSPECTUS</div>

This prospectus is part of a registration statement on Form S-3 that we filed with the U.S. Securities and Exchange Commission (the “SEC”), using a “shelf” registration process. Under a shelf registration process, we may from time to time offer and sell any combination of the securities described in this prospectus in one or more offerings in an aggregate of $125,000,000.

This prospectus provides you with a general description of the securities we may offer. Each time we sell the securities, to the extent required by law, a prospectus supplement will be provided that will contain specific information about the terms of the offering. One or more free writing prospectuses may also be provided to you in connection with the offering. The prospectus supplement and any related free writing prospectus may add, update or change information contained in this prospectus. This prospectus does not contain all of the information included in the registration statement. For a more complete understanding of the offering of the securities, you should refer to the registration statement, including its exhibits. You should carefully read this prospectus, the applicable prospectus supplement, and any applicable free writing prospectus, as well as the information and documents incorporated herein and therein by reference and the additional information under the heading “Where You Can Find More Information,” before making an investment decision.

We have not authorized any dealer, salesman or other person to give any