Company: BDRX
Filing Date: 2025-05-08
Form Type: POS AM
Source: 0001214659-25-007196
Chunk: 75

Company: Biodexa Pharmaceuticals Plc
Filing Date: 2025-05-08
Form: POS AM
Chunk 75
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 to access the text of such amendment. If an ADR holder or beneficial owner continues to hold an ADR or ADRs,
or an interest therein, after being so notified, such ADR holder and any beneficial owner are deemed to agree to such amendment and to
be bound by the Deposit Agreement as so amended. No amendment, however, will impair your right to surrender your Depositary Shares and
receive the underlying securities, except in order to comply with mandatory provisions of applicable law.

| 45 |

Any
amendments or supplements that (i) are reasonably necessary (as agreed by us and the depositary) in order for (a) the Depositary Shares
to be registered on Form F-6 under the Securities Act or (b) the Depositary Shares or Ordinary Shares to be traded solely in electronic
book-entry form and (ii) do not in either such case impose or increase any fees or charges to be borne by ADR holders, shall be deemed
not to prejudice any substantial rights of ADR holders or beneficial owners. Notwithstanding the foregoing, if any governmental body or
regulatory body should adopt new laws, rules or regulations that would require amendment or supplement of the Deposit Agreement or the
form of ADR to ensure compliance therewith, we and the depositary may amend or supplement the Deposit Agreement and the form of ADR (and
all outstanding ADRs) at any time in accordance with such changed laws, rules or regulations. Such amendment or supplement to the Deposit
Agreement in such circumstances may become effective before a notice of such amendment or supplement is given to ADR holders or within
any other period of time as required for compliance.

Notice of any amendment to
the Deposit Agreement or form of ADRs shall not need to describe in detail the specific amendments effectuated thereby, and failure to
describe the specific amendments in any such notice shall not render such notice invalid, provided, however, that, in each such case,
the notice given to the ADR holders identifies a means for ADR holders and beneficial owners to retrieve or receive the text of such amendment
(i.e., upon retrieval from the SEC's, the depositary's or our website or upon request from the depositary).

How may the Deposit Agreement be terminated?

The
depositary may at any time, and shall at our written direction, terminate the Deposit Agreement and the ADRs by mailing notice of such
termination to the registered holders of ADRs at least thirty (30) days prior to