Company: NCEL
Filing Date: 2025-09-10
Form Type: 424B3
Source: 0001213900-25-086600
Chunk: 384

Company: NewcelX Ltd.
Filing Date: 2025-09-10
Form: 424B3
Chunk 384
---
 Diseases, a team of researchers examined the risk factors and prevalence and impact of Long -COVID, among a representative sample of adults in the U.S. and reported that close to 19 million U.S. adults suffer from Long -COVID. According to a 2023 study by Nature Reviews Microbiology, at least 65 million individuals worldwide are estimated to have Long -COVID, with cases increasing daily. Additional Pre-Clinical Compounds NLS-3 NLS -3(Levophacetoperane SR) is a repurposed reverse ester of methylphenidate, a well -documentedpsychostimulant marketed for treatment of ADHD since the end of the 1950s. Animal experiments and tox studies have demonstrated a very satisfactory safety benefit and more recently, using the behavioral sensitization test in C57BL/6 mice, it has been reported that NLS -3(3 mg/kg) vs methylphenidate (6 mg/kg) or d -amphetamine(2 mg/kg) was not potentially addictive on this contextual sensitization and cross -sensitizationto d -amphetaminetest pointing -outthis stimulant as less addictive than marketed Scheduled II drugs in ADHD. NLS-8 NLS -8(Melafenoxate) is a melatonin ML1A receptor agonist, improved scopolamine -inducedamnesia. In a preclinical study to test the effects of NLS -8on memory in a model of Alzheimer’s Disease, the scopolamine -inducedamnesia in the novel object recognition test in mice. C57BL/6 male mice, 6 groups (N=16 mice/group), were subjected to two 12 -mintrials, 90 -minapart, in the NOR test: a sample (acquisition) trial during which they were exposed to two identical objects, and a choice (retention) trial during which they were exposed to two different objects presented, the familiar object (presented at the sample trial), and the novel object. They received 30 min before the sample trial i.p. injections of vehicle (control group), of scopolamine, of scopolamine + donepezil (1 mg/kg) or of 191 scopolamine + NLS -8(50, 100 or 150 mg/kg). Scopolamine was injected at 1.2 mg/kg. The results of this pre -clinicalstudy showed that NLS -8improved amnesia induced by scopolamine