Company: CERO
Filing Date: 2025-01-14
Form Type: 424B3
Source: 0001213900-25-003435
Chunk: 0

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-01-14
Form: 424B3
Chunk 0
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Filed Pursuant to Rule 424(b)(3)

Registration No. 333-278603

Prospectus Supplement No. 12

(To Prospectus dated May 1, 2024, as supplemented by

Prospectus Supplement No. 1, dated August 2, 2024

Prospectus Supplement No. 2, dated September 26, 2024

Prospectus Supplement No. 3, dated October 4, 2024

Prospectus Supplement No. 4, dated October 11, 2024

Prospectus Supplement No. 5, dated October 21, 2024

Prospectus Supplement No. 6, dated November 1, 2024

Prospectus Supplement No. 7, dated November 12, 2024

Prospectus Supplement No. 8, dated November 18, 2024

Prospectus Supplement No. 9, dated November 20, 2024

Prospectus Supplement No. 10, dated January 2, 2025 and

Prospectus Supplement No. 11, dated January 7, 2025)

<div align='center'>CERO THERAPEUTICS HOLDINGS, INC.

26,619,050 Shares of Common Stock</div>

This prospectus supplement no. 12 (this “Prospectus Supplement”)
amends and supplements the prospectus dated May 1, 2024 (as may be supplemented or amended from time to time, the “Prospectus”)
which forms part of our Registration Statement on Form S-1 (Registration Statement No. 333-278603). This Prospectus Supplement is being
filed to update and supplement the information included or incorporated by reference in the Prospectus with the information contained
in the attached Current Reports on Form 8-K, filed with the Securities and Exchange Commission (the “Securities and Exchange Commission”)
on January 7, 2025 and January 10, 2025 (the “Form 8-Ks”). Accordingly, we have attached the Form 8-Ks to this Prospectus
Supplement.

This Prospectus Supplement updates and supplements the information
in the Prospectus and is not complete without, and may not be delivered or utilized except in combination with, the Prospectus, including
any amendments or supplements thereto. This Prospectus Supplement should be read in conjunction with the Prospectus, and if there is