Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063906
Chunk: 0

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 0
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As confidentially submitted to the Securities and Exchange Commission on July 14 , 2025
This draft registration statement has not been publicly filed with the Securities and Exchange Commission
and all information herein remains strictly confidential. Registration No. 333-[] UNITED STATES
SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 _________________________________ FORM S-4
REGISTRATION STATEMENT UNDER
THE SECURITIES ACT OF 1933 _________________________________ Aptorum Group Limited (Exact name of registrant as specified in its charter) _________________________________

| Cayman Islands                  |     |                         2834 |     | Not Applicable     |
| (State or Other Jurisdiction of 
 Incorporation or Organization)  |     | -Primary Standard Industrial 
   Classification Code Number |     | -I.R.S. Employer   
 Identification No. |

17 Hanover Square
London W1S 1BN, United Kingdom +44 20 80929299 (Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices) _________________________________ Copies of all communications, including communications sent to agent for service, should be sent to:

| Louis Taubman, Esq.             
 Hunter Taubman Fischer & Li LLC 
 950 Third Avenue, 19th Floor    
 New York, NY 10022              
 Tel: (917) 512-0827             |     | Jonathan Deblinger, Esq.       
 John J. Hart, Esq.             
 Ellenoff Grossman & Schole LLP 
 1345 Avenue of the Americas    
 New York, NY 10105-0302        
 Tel: (212) 370-1300            |

_________________________________ Approximate date of commencement of proposed sale of the securities to the public: As soon as practicable after the effective date of this registration statement and the satisfaction or waiver of all other conditions under the Merger Agreement described herein. If the securities being registered on this Form are being offered in connection with the formation of a holding company and there is compliance with General Instruction G, check the following box: ☐ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post -effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the