Company: GAME
Filing Date: 2025-07-16
Form Type: 424B5
Source: 0001641172-25-019931
Chunk: 1

Company: GameSquare Holdings, Inc.
Filing Date: 2025-07-16
Form: 424B5
Chunk 1
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 Factors” section beginning on page S-12 of this prospectus supplement and any other risk factors contained in any applicable prospectus supplement and in the documents incorporated by reference herein and therein.

NEITHER THE UNITED STATES SECURITIES AND EXCHANGE COMMISSION (THE “SEC”) NOR ANY STATE SECURITIES COMMISSION OR REGULATOR HAS APPROVED OR DISAPPROVED THESE SECURITIES, NOR PASSED UPON THE ADEQUACY OR ACCURACY OF THE PROSPECTUS OR THIS PROSPECTUS SUPPLEMENT. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENCE.

|                                           |     | Per Share |     | Per Pre-Funded Warrant |     | Total                         
 Without Over-Allotment Option |     | With Over Allotment Option |
|:------------------------------------------|:----|:----------|:----|:-----------------------|:----|:------------------------------|:----|:---------------------------|
| Public offering price                     |     | $         |     | $                      |     | $                             |     | $                          |
| Underwriting discounts and commissions(1) |     | $         |     | $                      |     | $                             |     | $                          |
| Proceeds to GameSquare, before expenses   |     | $         |     | $                      |     | $                             |     | $                          |

| (1) | Includes                                                                       
 an underwriting discount of 7.0%. See “Underwriting” beginning on page S-18    
 of this Prospectus Supplement for                                              
 additional information regarding the compensation payable to the underwriters. |

We have granted the underwriters
an option for a period of 45 days from the date of this Prospectus Supplement to purchase up to an additional ______ shares of our Common
Stock or Pre-Funded Warrants from us at the public offering price, less underwriting discounts and commissions.

The underwriters expect to deliver the shares
of Common Stock and the pre-funded warrants to purchasers on or about July ____, 2025.

<div align='center'>Lucid Capital Markets

The date of this Prospectus Supplement is July __, 2025.</div>

<div align='center'>TABLE OF CONTENTS OF THE PROSPECTUS SUPPLEMENT</div>

|                                             | Page |
| ABOUT                                       
 THIS PROSPECTUS SUPPLEMENT                  | S-1  |
| FORWARD-LOOKING                             
 INFORMATION                                 | S-2  |
| INCORPORATION                               
 OF CERTAIN INFORMATION BY REF