Company: RGNX
Filing Date: 2025-11-26
Form Type: S-3
Source: 0001193125-25-300539
Chunk: 25

Company: REGENXBIO Inc.
Filing Date: 2025-11-26
Form: S-3
Chunk 25
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 beneficial interests in a global security are required to be shown on and effected through the book entry system maintained by the depositary (or its nominee), with respect to participants’ interests, or any participant, with respect to interests of persons held by participants on their behalf. Payments, transfers and exchanges relating to beneficial interests in a global security will be subject to policies and procedures of the depositary and must be effected through the depositary’s (or its nominee’s) book entry system. The depositary’s policies and procedures may change from time to time. We and the trustee have no responsibility or liability for the depositary’s or any participant’s records with respect to beneficial interests in a global security. Events of Default Unless we indicate otherwise in a prospectus supplement with respect to a particular series of debt securities, the following will be events of default for any series of debt securities under the indenture:

| • |     | we do not pay the principal of, or any premium on, a debt security of the series on its due date; |

| • |     | we do not pay interest on a debt security of the series within 30 days of its due date; |

| • |     | any guarantee with respect to the particular series of debt securities ceases to be of full force and effect; |

| • |     | we (or any guarantor) remain in breach of a covenant in respect of debt securities of the series for 60 days                                                                                                                                        
 after we (or the applicable guarantor) receive a written notice of default from the trustee or holders of at least 25% of the aggregate principal amount of debt securities of the series specifying the default and demanding that it be remedied; |

| • |     | we file for bankruptcy or certain other events of bankruptcy, insolvency or reorganization occur; and |

| • |     | any other event of default occurs in respect of debt securities of the series described in the prospectus 
 supplement.                                                                                               |

The trustee may withhold notice to the holders of debt securities of any default, except in the payment of principal, premium or interest, if it considers the withholding of notice to be in the best interests of the holders. Remedies if an Event of Default Occurs If an event of default has occurred and has not been cured or waived, the trustee or the holders of not less than 25% in aggregate principal amount of the debt securities of the affected series may declare the unpaid principal, premium, if any, and accrued and unpaid interest of all the debt securities of