Company: HURA
Filing Date: 2025-05-06
Form Type: S-4/A
Source: 0001193125-25-113920
Chunk: 0

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-05-06
Form: S-4/A
Chunk 0
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As filed with the U.S. Securities and Exchange Commission on May 6, 2025 Registration No. 333-284787 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-4 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 TUHURA BIOSCIENCES, INC. (Exact Name of Registrant as Specified in Its Charter)

| Nevada                   |     |                                                    2834 |     | 99-0360497         |
| (State of Incorporation) |     | -Primary Standard Industrial Classification Code Number |     | -IRS Employer      
 Identification No. |

10500 University Center Dr., Suite 110 Tampa, Florida 33612 Telephone: ( 813) 875-6600 (Address, including Zip Code, and Telephone Number, Including Area Code, of Registrant’s Principal Executive Offices) James Bianco, M.D. President and Chief Executive Officer TuHURA Biosciences, Inc. 10500 University Center Dr., Suite 110 Tampa, Florida 33612 Telephone: ( 813) 875-6600 (Name, Address, including Zip Code, and Telephone Number, including Area Code, of Agent for Service) With a copy to:

| Curt P. Creely, Esq.               
 Garrett F. Bishop, Esq.            
 Foley & Lardner LLP                
 100 North Tampa Street, Suite 2700 
 Tampa, Florida 33602               
 (813)229-2300                      |     | Craig W. Philips               
 President and Secretary        
 Kineta, Inc.                   
 7683 SE 27th Street, Suite 481 
 Mercer Island, WA 98040        
 (206)378-0400                  |     | Albert Vanderlaan, Esq.            
 Orrick, Herrington & Sutcliffe LLP 
 222 Berkeley Street, Suite 2000    
 Boston, Massachusetts 02116        
 (617)880-2219                      |

Approximate date of commencement of proposed sale of the securities to the public: As soon as practicable after this registration statement is declared effective. If the securities being registered on this form are being offered in connection with the formation of a holding company and there is compliance with General Instruction G, please check the following box. ☐ If this form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act of 1933, as amended (the “Sec