Company: CIB
Filing Date: 2025-05-15
Form Type: POS AM
Source: 0001193125-25-120631
Chunk: 1

Company: Grupo Cibest S.A.
Filing Date: 2025-05-15
Form: POS AM
Chunk 1
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 American depositary shares) to Bancolombia’s shareholders under the Securities Act in connection with a meeting of such shareholders held on April 23, 2025 to approve
the modification to the corporate structure of Bancolombia pursuant to which the Registrant will be established as the holding company for Bancolombia and its affiliates and certain related corporate transactions will be undertaken (the
“Corporate Structure Changes”). The Corporate Structure Changes are expected to be effected as of May 16, 2025. There have been no material changes to the information set forth in the Registration Statement in connection with or that
will result from the Corporate Structure Changes. In connection with the Corporate Structure Changes, each common share of Bancolombia will be exchanged for one common share of the Registrant and each preferred share of Bancolombia will be exchanged
for one preferred share of the Registrant, except for shares of Bancolombia held by the Registrant. Holders of each American depositary share representing four preferred shares of Bancolombia will receive one new American depositary share
representing four preferred shares of the Registrant.

EXHIBIT INDEX

| Number |     | Description                                                                                                                          |
| 5.1    |     | Opinion of Brigard Urrutia Abogados SAS regarding the legality of securities being registered.                                       |
| 23.1   |     | Consent of Brigard Urrutia Abogados SAS (included as part of its opinion filed as Exhibit 5.1 and incorporated by reference herein). |

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized in the City of Medellin, Republic of Colombia, on May 15, 2025.

| GRUPO CIBEST S.A. |     |                                                            |
| By:               |     | /s/ Mauricio Botero Wolff                                  |
|                   |     | Name: Mauricio Botero Wolff                                |
|                   |     | Title: Vice President of Finance (Chief Financial Officer) |

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities indicated on May 15, 2025.

| Name                              |     | Title                                               |
| *                                 |     | President (Chief Executive Officer)                 |
| Juan Carlos Mora Uribe