Company: ZLAB
Filing Date: 2025-04-18
Form Type: CORRESP
Source: 0001628280-25-018396
Chunk: 0

Company: Zai Lab Ltd
Filing Date: 2025-04-18
Form: CORRESP
Chunk 0
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| SIDLEY |     | SIDLEY AUSTIN LLP      
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April 18, 2025

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attn: Chris Edwards

Tyler Howes

Kevin Vaughn

Jenn Do

Re: Zai Lab Limited

Form 10-K for Fiscal Year Ended December 31, 2024

Filed February 27, 2025

File No. 001-38205

Ladies and Gentlemen:

On behalf of our client, Zai Lab Limited, an exempted company incorporated in the Cayman Islands (the “Company”), we submit to the staff (the “Staff”) of the Securities and Exchange Commission (the “Commission”) this letter setting forth the Company’s response to the comment contained in the Staff’s letter dated April 8, 2025 on the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2024 (“Annual Report”). The Staff’s comment is repeated below in italics and is followed by the Company’s response. Defined terms used but not defined herein have the meanings assigned to such terms in the Annual Report.

#### Form 10-K for Fiscal Year Ended December 31, 2024

#### General
1. We note the changes to your disclosure appearing at the outset of your annual report, in Item 1. Business and Item 1A. Risk Factors relating to legal and operational risks associated with operating in China. It is unclear to us that there have been changes in the regulatory environment in the PRC since our prior 10-K review completed on June 10, 2022, warranting revised disclosure to mitigate the challenges you face and related disclosures. The Sample Letters to China-Based Companies sought specific disclosure

| Sidley Austin (DC) LLP is a Delaware limited liability partnership doing business as Sidley Austin LLP and practicing in affiliation with other Sidley Austin partnerships. |

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relating to the risk that the PRC government may intervene in or influence your operations at any time, or may