Company: XXII
Filing Date: 2025-11-04
Form Type: 424B5
Source: 0001493152-25-020754
Chunk: 21

Company: 22nd Century Group, Inc.
Filing Date: 2025-11-04
Form: 424B5
Chunk 21
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TS, which could 
 severely impair our results of operations and liquidity.                                                                          |

| ● | The                                                                                                                               
 loss of a significant customer for whom we manufacture tobacco products could have an adverse impact on our results of operation. |

| ● | Product                                                                                                     
 liability claims, product recalls, or other claims could cause us to incur losses or damage our reputation. |

| ● | The                                                               
 FDA could force the removal of our products from the U.S. market. |

| ● | Negative                                                                                                                           
 press from being in the hemp/cannabis space could have a material adverse effect on our business, financial condition, and results 
 of operations.                                                                                                                     |

| ● | Any                                                                                                    
 business-related cannabinoid production is dependent on laws pertaining to the hemp/cannabis industry. |

| ● | Certain                                                                                                                            
 of our proprietary rights have expired or may expire or may not otherwise adequately protect our intellectual property, products   
 and potential products, and if we cannot obtain adequate protection of our intellectual property, products and potential products, 
 we may not be able to successfully market our products and potential products.                                                     |

| ● | We                                                                                                                               
 license certain patent rights from third-party owners. If such owners do not properly maintain or enforce the patents underlying 
 such licenses, our competitive position and business prospects could be harmed.                                                  |

| ● | Our                                                            
 stock price may be highly volatile and could decline in value. |

| ● | We                                                                                                                                 
 are a named defendant in certain litigation matters, including federal securities class action lawsuits and derivative complaints; 
 if we are unable to resolve these matters favorably, then our business, operating results and financial condition may be adversely 
 affected.                                                                                                                          |

| ● | Future                                                                        
 sales of our common stock will result in dilution to our common stockholders. |

| ● | We                                                                                    
 do not expect to declare any dividends on our common stock in the foreseeable future. |

You also should carefully review the risk factors and cautionary statements described in the other documents we file or furnish from time to time with the SEC, including our Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. The forward-looking statements included in this prospectus and any other offering material, or in the documents incorporated by reference into this prospectus and any other offering material, are made only as of the date of the prospectus and any other offering material or the incorporated document.

We do not assume any obligation to update any forward-looking statements. We