Company: PSTV
Filing Date: 2025-06-20
Form Type: S-1/A
Source: 0001193125-25-142935
Chunk: 3

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-06-20
Form: S-1/A
Chunk 3
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 the selling
stockholder may sell or otherwise dispose of the common stock being registered pursuant to this prospectus. The selling stockholder is an “underwriter” within the meaning of Section 2(a)(11) of the Securities Act of 1933, as amended
(the “Securities Act”).

The selling stockholder will pay all brokerage fees and commissions and similar expenses in connection
with any resale or disposition of the shares of common stock described in this prospectus by the selling stockholder. We will pay the expenses incurred in registering under the Securities Act the offer and sale of the shares of common stock to which
this prospectus relates by the selling stockholder, including legal and accounting fees. See “Plan of Distribution”.

Our common
stock is currently listed on the Nasdaq Capital Market (“Nasdaq”) under the symbol “PSTV”. On June 16, 2025, the closing price of our common stock, as reported on Nasdaq, was $0.31 per share.

Investing in our securities involves a high degree of risk. These risks are described in the “ Risk Factors” section on page 3 of this prospectus. You should also consider the risk factors described or referred to in any documents incorporated by reference in this prospectus, and in any applicable prospectus supplement, before investing in these securities.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is , 2025

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS                                                               |     | ii |
| PROSPECTUS SUMMARY                                                                  |     |  1 |
| THE OFFERING                                                                        |     |  2 |
| FORWARD-LOOKING STATEMENTS                                                          |     |  7 |
| THE LINCOLN PARK TRANSACTION                                                        |     |  8 |
| USE OF PROCEEDS                                                                     |     | 14 |
| DILUTION                                                                            |     | 15 |
| THE SELLING STOCKHOLDER                                                             |     | 16 |
| MARKET PRICE OF OUR COMMON STOCK AND RELATED STOCKHOLDER                            
 MATTERS                                                                             |     | 18 |
| DESCRIPTION OF CAPITAL STOCK                                                        |     | 19 |
| PLAN OF DISTRIBUTION                                                                |     | 24 |
| LEGAL MATTERS                                                                       |     | 26 |
| EXPERTS                                                                             |     | 26 |
| WHERE YOU CAN FIND MORE