Company: SCLXW
Filing Date: 2025-07-23
Form Type: 424B3
Source: 0001193125-25-163077
Chunk: 12

Company: Scilex Holding Co
Filing Date: 2025-07-23
Form: 424B3
Chunk 12
---
 |     | Warrant Exchange Agreement, dated as of July 22, 2025, by and between the Company and Nomis Bay Ltd.                                        |
| 10.4*   |     | Warrant Exchange Agreement, dated as of July 22, 2025, by and between the Company and BPY Limited.                                          |
| 10.5*   |     | Warrant Exchange Agreement, dated as of July 22, 2025, by and between the Company and 3i LP.                                                |
| 10.6    |     | Form of New Tranche B Warrant                                                                                                               |
| 10.7

#   |     | Option Agreement for the Repurchase of Warrants, dated July 22, 2025, by and between Scilex Holding Company and Oramed Pharmaceuticals Inc. |
| 104     |     | Cover Page Interactive Data File, formatted in Inline Extensible Business Reporting Language (iXBRL).                                       |

| * | Certain of the exhibits and schedules to this Exhibit have been omitted in accordance with Regulation S-K Item 601(a)(5). The Registrant agrees to furnish a copy of all omitted exhibits and schedules to the SEC upon its request. |

| 

# | Certain identified information has been omitted pursuant to Item 601(b)(10) of Regulation S-K because such                                                                                                                          
 information is both (i) not material and (ii) information that the Registrant treats as private or confidential. The Registrant hereby undertakes to furnish supplemental copies of the unredacted exhibit upon request by the SEC. |

6

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

| SCILEX HOLDING COMPANY |     |                                     |
| By:                    |     | /s/ Jaisim Shah                     |
| Name:                  |     | Jaisim Shah                         |
| Title:                 |     | Chief Executive Officer & President |

Date: July 23, 2025 7

Exhibit 10.1

COMMON STOCK PURCHASE AGREEMENT

dated as of July 22, 2025

by and between

SCILEX HOLDING COMPANY

and

TUMIM STONE CAPITAL, LLC

TABLE OF CONTENTS

| ARTICLE I DEFINITIONS                                     |     |                                                                                                           |     |  1 |
| ARTICLE II PURCHASE AND