Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 63

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 63
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 respect to any matter to be voted upon as to which we inform the depositary that (a) we do not wish such proxy to be given, (b) substantial opposition exists, or (c) the rights of holders of deposited securities may be adversely affected. Please note that the ability of the depositary to carry out voting instructions may be limited by practical and legal limitations and the terms of the securities on deposit. We cannot assure you that you will receive voting materials in time to enable you to return voting instructions to the depositary in a timely manner. Fees and Charges As an ADS holder, you will be required to pay the following fees under the terms of the deposit agreement:

| Service                                                                                                                                        |     | Fee                                                                                     |
| Issuance of ADSs (e.g., an issuance of ADS upon a deposit of ordinary shares or upon a change in the ADS(s)-to-ordinary shares ratio),         
 excluding ADS issuances as a result of distributions of ordinary shares                                                                        |     | Up to $0.05 per ADS issued                                                              |
| Cancellation of ADSs (e.g., a cancellation of ADSs for delivery of deposited property or upon a change in the ADS(s)-to-ordinary shares ratio) |     | Up to $0.05 per ADS cancelled                                                           |
| Distribution of cash dividends or other cash distributions (e.g., upon a sale of rights and other entitlements)                                |     | Up to $0.05 per ADS held                                                                |
| Distribution of ADSs pursuant to (i) share dividends or other distributions, or (ii) exercise of rights to purchase additional ADSs            |     | Up to $0.05 per ADS held                                                                |
| Distribution of securities other than ADSs or rights to purchase additional ADSs (e.g., upon a spin-off)                                       |     | Up to $0.05 per ADS held                                                                |
| ADS services                                                                                                                                   |     | Up to $0.05 per ADS held on the applicable record date(s) established by the depositary |

As an ADS holder you will also be responsible to pay certain charges such as:

| • |     | taxes (including applicable interest and penalties) and other governmental charges; |

| • |     | the registration fees as may from time to time be in effect for the registration of ordinary shares on the share                                                                        
 register and applicable to transfers of ordinary shares to or from the name of the custodian, the depositary or any nominees upon the making of deposits and withdrawals, respectively; |

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