Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 11

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 11
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, Arizona and Florida — and secondarily in several mountain, southeastern and other states, and in Canada and Mexico. Comerica has consolidated most of its banking business into Comerica Bank, which is chartered by the State of Texas, and at the state level is supervised and regulated by the Texas Department of Banking. Comerica Bank is a member of the Federal Reserve System and supervised and regulated by the Federal Reserve Bank of Dallas,

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and has branches in Texas, Michigan, California, Florida and Arizona. Comerica Bank & Trust, National Association is chartered under federal law and is subject to supervision and
regulation by the Office of the Comptroller of the Currency. Comerica Bank & Trust, National Association is also a member of the Federal Reserve System. The deposits of Comerica Bank and Comerica Bank & Trust, National Association
are insured by the Deposit Insurance Fund of the FDIC to the extent provided by law. Comerica is a bank holding company under the Bank Holding Company Act of 1956, as amended, and has elected to become a financial holding company under the
provisions of the Gramm-Leach-Bliley Act. Accordingly, Comerica is subject to supervision and regulation at the federal level by the Board of Governors of the Federal Reserve System (the “Federal Reserve”).

Comerica’s principal executive office is located at Comerica Bank Tower, 1717 Main Street, MC 6404, Dallas, Texas 75201, and its
telephone number is (833) 571-0486.

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THE OFFERING The following description contains basic information about the depositary shares, the Series B Preferred Stock represented thereby and this offering. This description is not complete and does not contain all of the information that you should consider before investing in the depositary shares. For a more complete understanding of the depositary shares and the Series B Preferred Stock represented thereby, you should read “Description of the Series B Preferred Stock” and “Description of Depositary Shares” in this prospectus supplement as well as “Description of Capital Stock— Preferred Stock” and “Description of Depositary Shares” in the accompanying prospectus. To the extent the following information is inconsistent with the information in the accompanying prospectus, you should rely on the following information.

| Issuer | Comerica Incorporated, a Delaware corporation. |

| Securities Offered | 16,000,000 depositary shares, each representing a 1/40