Company: SCLXW
Filing Date: 2025-04-01
Form Type: S-8
Source: 0001193125-25-069295
Chunk: 1

Company: Scilex Holding Co
Filing Date: 2025-04-01
Form: S-8
Chunk 1
---
 the requirements of Form S-8 under the Securities Act of 1933, as amended (the “Securities
Act”), to register (i) 7,311,356 additional shares of common stock, $0.0001 par value per share (“Common Stock”), of the Registrant issuable pursuant to the Scilex Holding Company 2022 Equity Incentive Plan, as amended (the “2022
Plan”) and (ii) 1,827,839 additional shares of Common Stock issuable pursuant to the Scilex Holding Company 2022 Employee Stock Purchase Plan (the “2022 ESPP”). The Registrant’s stockholders have previously approved the 2022 Plan
and the 2022 ESPP, including the shares of Common Stock available for issuance pursuant thereto.

Pursuant to the Registration Statement
on Form S-8 (File No. 333-269256) filed by the Registrant with the Securities and Exchange Commission (the
“Commission”) on January 17, 2023, the Registration Statement on Form S-8 (File No. 333-271739) filed by the Registrant with the Commission on May 9, 2023 and the Registration Statement on Form S-8 (File No.
333-278283) filed by the Registrant with the Commission on March 27, 2024 (collectively, the “Prior
Registration Statements”), the Registrant previously registered an aggregate of 52,875,214 shares of Common Stock under the 2022 Plan and 4,476,601 shares of Common Stock under the 2022 ESPP.

In accordance with General Instruction E to Form S-8, the contents of the Prior Registration
Statements are hereby incorporated by reference.

PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

| ITEM 3. | INCORPORATION OF DOCUMENTS BY REFERENCE. |

The following documents filed by the Registrant with the Commission are hereby incorporated by reference into this Registration Statement:

All other reports and other documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part of this Registration Statement from the date of the filing of such reports and documents, except as