Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 81

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 81
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 FIRM

### KPMG AZSA LLC
<div align='center'>AZSA Center Building

1-2, Tsukudo-cho

Shinjuku-ku, Tokyo 162-8551

Japan</div>

#### TAKEDA U.S. FINANCING, INC.
<div align='center'>$1,650,000,000 5.200% Guaranteed Notes due 2035

$750,000,000 5.900% Guaranteed Notes due 2055</div>

#### Fully and Unconditionally Guaranteed by

### TAKEDA PHARMACEUTICAL COMPANY LIMITED
<div align='center'>Joint Lead Managers and Joint Bookrunners</div>

| J.P. Morgan |     | SMBC NIKKO |

| BNP PARIBAS |     | BofA Securities |     | HSBC |     | Morgan Stanley |

<div align='center'>Co-Managers</div>

| Barclays |     | Citigroup |     | COMMERZBANK |     | Goldman Sachs & Co. LLC |

| Mizuho Securities |     | Wells Fargo Securities |