Company: PFSA
Filing Date: 2025-02-12
Form Type: S-4/A
Source: 0001213900-25-012354
Chunk: 930

Company: Profusa, Inc.
Filing Date: 2025-02-12
Form: S-4/A
Chunk 930
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 11, 2025 |
|:-------------------|:----|:-------------------|:----|:------------------|
| Peter O’Rourke     |     |                    |     |                   |
| /s/ Jack Stover    |     | Director           |     | February 11, 2025 |
| Jack Stover        |     |                    |     |                   |
| /s/ Fred Knechtel  |     | Director           |     | February 11, 2025 |
| Fred Knechtel      |     |                    |     |                   |
| /s/ Ed Johnson     |     | Director           |     | February 11, 2025 |
| Ed Johnson         |     |                    |     |                   |
| /s/ Lauren Chung   |     | Director           |     | February 11, 2025 |
| Lauren Chung       |     |                    |     |                   |

II-4

Pursuant to the requirements of the Securities Act of 1933, as amended, the co -registranthas duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, on February 11, 2025.

| PROFUSA, INC. |     |                         |
| By:           |     | /s/ Ben Hwang           |
| Name:         |     | Ben Hwang               |
| Title:        |     | Chief Executive Officer |

POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Ben Hwang as attorney -in-factand agent, with full power of substitution and re -substitution, to sign on his or her behalf, individually and in any and all capacities, including the capacities stated below, any and all amendments (including post -effectiveamendments) to this Registration Statement and any registration statements filed by the registrant pursuant to Rule 462(b) of the Securities Act of 1933, as amended, relating thereto and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting to said attorney -in-factand agent, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney