Company: RGNT
Filing Date: 2025-01-27
Form Type: DRS/A
Source: 0001213900-25-006676
Chunk: 118

Company: REGENTIS BIOMATERIALS LTD.
Filing Date: 2025-01-27
Form: DRS/A
Chunk 118
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, MOCART taken, were superior to those seen with the traditional
microfracture procedures, which microfracture results were used in both the Pilot study and current ongoing pivotal trial
(referenced below), and these results continued to improve over the four years follow up period. Presented hereunder are the main
findings from these trials. At two years, the resultant KOOS score for GelrinC provided an improvement of about 100% greater pain
reduction than that of historical microfracture procedure data, as seen in Pilot Study Data figure chart below where we received a
KOOS score of about 28 for GelrinC at two years, with microfracture having a KOOS score of about 14 at two years. Microfracture is
considered the “gold standard” among the various commonly used procedures for the treatment of these patients. Based on MRI images, the MOCART qualitative score for GelrinC has reached a score over 80, within 24 months. After two years, the resultant KOOS score for GelrinC continued to show improvement over the course of an additional 24 months (so far, 44 patients out of the 56 patients followed up at 18 months and 42 out of 56 patients followed up at 24 months; about 80% and 75% of the initial 56 patients, respectively).

<div align='center'>72

Pilot Study Data</div>

The KOOS is a patient-reported
outcome measurement instrument, developed to assess the patient’s opinion about their knee and associated problems. The KOOS evaluates
both short-term and long-term consequences of knee injury and also consequences of primary osteoarthritis, or OA. It holds 42 items in
five separately scored subscales: KOOS Pain, KOOS Symptoms, Function in daily living, or KOOS ADL, Function in Sport and Recreation, or
KOOS Sport/Rec, and knee-related Quality of Life, or KOOS QOL (Roos and Lohmander 2003). The score above is presented in percentages.

The MOCART score is a 9-part
and a 29-item scoring system, resulting in a final cartilage repair tissue score between 0 and 100 points; 0 points represents the worst
imaginable score, while 100 points represent the best imaginable score. When patients measure pain, they sometimes fill out reports with
subjective answers, and therefore we also use an