Company: BDRX
Filing Date: 2025-11-17
Form Type: POS AM
Source: 0001214659-25-016809
Chunk: 82

Company: Biodexa Pharmaceuticals Plc
Filing Date: 2025-11-17
Form: POS AM
Chunk 82
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 or supplement to the Deposit Agreement in
such circumstances may become effective before a notice of such amendment or supplement is given to ADR holders or within any other period
of time as required for compliance.

| 43 |

Notice of any amendment to the Deposit
Agreement or form of ADRs shall not need to describe in detail the specific amendments effectuated thereby, and failure to describe the
specific amendments in any such notice shall not render such notice invalid, provided, however, that, in each such case, the notice given
to the ADR holders identifies a means for ADR holders and beneficial owners to retrieve or receive the text of such amendment (i.e.,upon retrieval from the SEC’s, the depositary’s or our website or upon request from the depositary).

How may the Deposit Agreement be terminated?

The depositary
may at any time, and shall at our written direction, terminate the Deposit Agreement and the ADRs by mailing notice of such termination
to the registered holders of ADRs at least thirty (30) days prior to the date fixed in such notice for such termination; provided, however,
if the depositary shall have (i) resigned as depositary under the Deposit Agreement, notice of such termination by the depositary shall
not be provided to registered ADR holders unless a successor depositary shall not be operating under the Deposit Agreement within sixty
(60) days of the date of such resignation, and (ii) been removed as depositary under the Deposit Agreement, notice of such termination
by the depositary shall not be provided to registered holders of ADRs unless a successor depositary shall not be operating under the
Deposit Agreement on the 60th day after our notice of removal was first provided to the depositary. Notwithstanding anything to the contrary
in the Deposit Agreement, the depositary may terminate the Deposit Agreement (a) without notifying us, but subject to giving thirty (30)
days' notice to the ADR holders, under the following circumstances: (i) in the event of our bankruptcy, liquidation proceedings or insolvency,
(ii) if our Depositary Shares are delisted from a “national securities exchange” (that has registered with the Commission
under Section 6 of the Securities Exchange Act of 1934, as amended), (iii) if we effect (or will effect) a redemption of all or substantially
all of the deposited securities, or a cash or share distribution representing a return of all or substantially all of the value of the
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