Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 325

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 325
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 and regulations of the SEC and Nasdaq Listing Rules. The responsibilities of the Audit Committee are included in a written charter. The Audit Committee assists our Board in fulfilling our Board’s oversight responsibilities with respect to our accounting and financial reporting processes, the systems of internal control over financial reporting and audits of financial statements and reports, the performance of our internal audit function, the quality and integrity of our financial statements and reports, the qualifications, independence and performance of our independent registered public accounting firm, and our compliance with legal and regulatory requirements. For this purpose, the Audit Committee performs several functions. The Audit Committee’s responsibilities include, among others:

| • |     | appointing, determining the compensation of, retaining, overseeing and evaluating our independent registered                                         
 public accounting firm and any other registered public accounting firm engaged for the purpose of performing other review or attest services for us; |

| • |     | prior to commencement of the audit engagement, reviewing and discussing with the independent registered public                                                                                                                                          
 accounting firm a written disclosure by the prospective independent registered public accounting firm of all relationships between us, or persons in financial oversight roles with us, and such independent registered public accounting firm or their 
 affiliates;                                                                                                                                                                                                                                             |

| • |     | determining and approving engagements of the independent registered public accounting firm, prior to commencement 
 of the engagement, and the scope of and plans for the audit;                                                      |

| • |     | monitoring the rotation of partners of the independent registered public accounting firm on our audit engagement; |

| • |     | reviewing with management and the independent registered public accounting firm any fraud that includes                                                      
 management or other employees who have a significant role in our internal control over financial reporting and any significant changes in internal controls; |

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| • |     | establishing and overseeing procedures for the receipt, retention and treatment of complaints regarding                                                                                    
 accounting, internal accounting controls or auditing matters and the confidential and anonymous submission by employees of concerns regarding questionable accounting or auditing matters; |

| • |     | reviewing the results of management’s efforts to monitor compliance with our programs and policies designed 
 to ensure compliance with laws and rules;                                                                   |

| • |     | overseeing our programs, policies, and procedures related to our information technology systems, including 
 information asset security and data protection; and                                                        |

| • |     | reviewing and discussing with management and the independent registered public accounting firm the results of the                                                                                                                                
 annual audit and the independent registered public accounting firm’s assessment of the quality and acceptability of our accounting principles and practices and all other matters required to