Company: PRGO
Filing Date: 2025-05-07
Form Type: S-8
Source: 0001193125-25-115086
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Company: PERRIGO Co plc
Filing Date: 2025-05-07
Form: S-8
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As Filed with the Securities and Exchange Commission on May 7, 2025 Registration Statement No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 PERRIGO COMPANY PLC (Exact name of registrant as specified in its charter)

| Ireland                         |     | Not Applicable     |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -IRS Employer      
 Identification No. |

The Sharp Building, Hogan Place Dublin 2, Ireland Telephone: +353 1 7094000 (Address, including zip code, and telephone number, including area code, of registrant’s principal executive office) PERRIGO COMPANY PLC 2019 LONG-TERM INCENTIVE PLAN (Full Title of the Plan) Charles M. Atkinson Executive Vice President, General Counsel and Company Secretary Perrigo Company plc 515 Eastern Avenue Allegan, Michigan 49010 Telephone: (269) 686-1941 (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies to: Alan J. Fishman Sullivan & Cromwell LLP 125 Broad St New York, New York 10004 (212) 558-4000 Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-acceleratedfiler, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2of the Exchange Act.

| Large accelerated filer |     | ☒                                               |     | Accelerated filer         |     | ☐ |
| Non-accelerated filer   |     | ☐ (Do not check if a smaller reporting company) |     | Smaller reporting company |     | ☐ |
|                         |     |                                                 |     | Emerging growth company   |     | ☐ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

EXPLANATORY NOTE This Registration Statement on Form S-8(the “ Registration Statement”) relates to the registration of ordinary