Company: TEM
Filing Date: 2025-03-07
Form Type: 424B3
Source: 0001193125-25-049935
Chunk: 17

Company: Tempus AI, Inc.
Filing Date: 2025-03-07
Form: 424B3
Chunk 17
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 maintain and foster an open avenue of communication between management and the independent 
 registered public accounting firm;                                                                    |

| • |     | discussing the scope and results of the audit with the independent registered public accounting firm, and 
 reviewing, with management and the independent accountants, our interim and year-end operating results;   |

| • |     | developing procedures for employees to submit concerns anonymously about questionable accounting or audit 
 matters;                                                                                                  |

| • |     | reviewing our policies on risk assessment and risk management; |

| • |     | reviewing related party transactions; |

| • |     | obtaining and reviewing a report by the independent registered public accounting firm at least annually, that                                                              
 describes its internal quality-control procedures, any material issues with such procedures, and any steps taken to deal with such issues when required by applicable law; |

| • |     | approving (or, as permitted, pre-approving) all audit and all                                            
 permissible non-audit services to be performed by the independent registered public accounting firm; and |

| • |     | reviewing and discussing material risks relating to data privacy, technology and information security, 
 including cybersecurity.                                                                               |

11

Compensation Committee Our compensation committee consists of Peter J. Barris, David R. Epstein and Nadja West. The chair of our compensation committee is Mr. Barris. Our board of directors has determined that each of Messrs. Barris and Epstein and Ms. West is independent under Nasdaq listing standards and a “non-employeedirector” as defined in Rule 16b-3promulgated under the Exchange Act. The principal duties and responsibilities of our compensation committee include, among other things:

| • |     | approving the retention of compensation consultants and outside service providers and advisors; |

| • |     | reviewing and approving, or recommending that our board of directors approve, the compensation, individual and                                                                                                                          
 corporate performance goals and objectives and other terms of employment of our executive officers, including evaluating the performance of our chief executive officer and, with his assistance, that of our other executive officers; |

| • |     | reviewing and recommending to our board of directors the compensation of our directors; |

| • |     | administering our equity and non-equity incentive plans; |

| • |     | reviewing our practices and policies of employee compensation as they relate to risk management and 
 risk-taking incentives;                                                                             |

| • |     | reviewing and evaluating succession plans for the executive officers; |

| • |     | reviewing and approving, or