Company: SCLXW
Filing Date: 2025-07-23
Form Type: 424B3
Source: 0001193125-25-163077
Chunk: 121

Company: Scilex Holding Co
Filing Date: 2025-07-23
Form: 424B3
Chunk 121
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| SCILEX HOLDING COMPANY |     |                                              |
| By:                    |     | /s/ Jaisim Shah                              |
|                        |     | Name: Jaisim Shah                            |
|                        |     | Title: Chief Executive Officer and President |

| INVESTOR:                           |     |                           |
| TUMIM STONE CAPITAL, LLC            |     |                           |
| By: 3i Management, LLC, its Manager |     |                           |
| By:                                 |     | /s/ Maier Joshua Tarlow   |
|                                     |     | Name: Maier Joshua Tarlow |
|                                     |     | Title: Manager            |

[ Signature Page to Registration Rights Agreement]

Exhibit 10.3

WARRANT EXCHANGE AGREEMENT

This W ARRANT E XCHANGEA GREEMENT (the
“Agreement”), dated as of July 22, 2025, is by and between Scilex Holding Company, a Delaware corporation with offices located at 960 San Antonio Road, Palo Alto, CA 94303 (the “Company”) and the undersigned (the
“Holder”). Capitalized terms used but not defined herein are used with the respective meanings assigned to them in the Tranche B SPA (as defined below).

WHEREAS, prior to the date hereof, the Company issued, severally, certain promissory notes (the “Tranche B Notes”) and warrants to purchase shares of common stock, par value $0.0001 per share, of the Company (“Common Stock”) in the initial aggregate amount of 7,500,000 shares (not taking into account the Company’s
subsequent 1-for-35 reverse stock split, which became effective on April 15, 2025 (the “Reverse Stock Split”) to certain investors (the
“Tranche B Holders”) pursuant to that certain Securities Purchase Agreement, dated October 7, 2024 (the “Tranche B SPA”), of which a warrant to purchase shares of Common Stock in the initial aggregate amount of
1,920,000 shares (on a pre-Reverse Stock Split basis, which is currently exercisable for 54,857 shares on a post-Reverse Stock Split basis) is held by the Holder (the “Existing Tranche B Warrant”);

WHEREAS, the Existing Tranche B Warrant was issued pursuant to the Company’s Registration
Statement on Form S-3 (File No. 333-276245) (the “