Company: RNAC
Filing Date: 2025-05-08
Form Type: S-8
Source: 0001453687-25-000087
Chunk: 1

Company: Cartesian Therapeutics, Inc.
Filing Date: 2025-05-08
Form: S-8
Chunk 1
---
celerated filer   | R |     | Smaller reporting company | R |
|                         |   |     | Emerging growth company   | ☐ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

### EXPLANATORY NOTE
This registration statement on Form S-8 (the “Registration Statement”) is being filed for the purpose of registering an additional 1,030,694 shares of common stock, par value $0.0001 per share (the “Common Stock”), of Cartesian Therapeutics, Inc. (the “Registrant”) to be issued pursuant to the Registrant’s Amended and Restated 2016 Incentive Award Plan (the “Incentive Plan”) and an additional 450,000 shares of the Registrant’s Common Stock to be issued pursuant to the Registrant’s Amended and Restated 2018 Employment Inducement Incentive Award Plan (the “Inducement Plan”).

<div align='center'>2</div>

# PART II

### INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

## Item 3. Incorporation of Documents by Reference
The following documents filed with the Securities and Exchange Commission (the “Commission”) pursuant to the Securities Exchange Act of 1934, as amended (the “Exchange Act”), are hereby incorporated by reference into this registration statement:

• The Registrant’s definitive proxy statement on Schedule 14A for the 2025 annual meeting of stockholders, filed with the Commission on April 2 8 , 202 5 ;

• The Registrant’s Annual Report on Form 10-K for the year ended December 31, 2024, filed with the Commission on March 13, 2025 ;

• The Registrant's Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, filed with the Commission on May 8 , 202 5 ;

• The Registrant’s Current Reports on Form 8-K filed with the Commission on January 27, 2025 , April 8, 2025 and April 29 , 2025 (except for Item 7.01 and Exhibits 99.1 and 99.2 thereto); an d

• The description of the Registrant’s Common Stock contained in Exhibit 4.12