Company: XXII
Filing Date: 2025-06-20
Form Type: S-3
Source: 0001641172-25-015905
Chunk: 3

Company: 22nd Century Group, Inc.
Filing Date: 2025-06-20
Form: S-3
Chunk 3
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 section entitled “Risk Factors” on page 1 of this prospectus, our most recent Annual Report on Form 10-K, subsequently filed Quarterly Reports on Form 10-Q and in any applicable prospectus supplement and/or other offering material for a discussion of certain factors which should be considered in an investment of the common stock which may be offered hereby.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is , 2025.</div>

<div align='center'>TABLE OF CONTENTS</div>

| About This Prospectus                           | ii |
| 22nd Century Group, inc.                        |  1 |
| Use of Proceeds                                 |  1 |
| Risk Factors                                    |  1 |
| Description of Capital Stock                    |  2 |
| Selling Stockholders                            |  7 |
| Plan of Distribution                            |  9 |
| Legal Matters                                   | 11 |
| Experts                                         | 11 |
| Where You Can Find More Information             | 11 |
| Incorporation of Certain Documents by Reference | 11 |

| i |

<div align='center'>About This Prospectus</div>

Unless the context otherwise requires, references in this prospectus to “Company,” “22 ndCentury,” “we,” “us,” “our,” and “ours” refer to 22 ndCentury Group, Inc. and its subsidiaries where the context so requires.

This prospectus is part of a registration statement that we filed with the Securities and Exchange Commission, or SEC, using a “shelf” registration process. Under this shelf registration process, the selling stockholders may, from time to time, sell the shares of common stock described in this prospectus in one or more offerings. A prospectus supplement and/or other offering material may also add, update or change information contained in this prospectus. You should read this prospectus, any prospectus supplement and any other offering material together with additional information described under the heading “Where You Can Find More Information.”

You should rely only on the information contained or incorporated by reference in this prospectus and in any prospectus supplement or other offering material. We have not authorized any other person to provide you with different information. If anyone provides you with different or inconsistent information, you should not rely on it. We are not making offers to sell the securities in any jurisdiction in