Company: SCLXW
Filing Date: 2025-11-14
Form Type: 424B3
Source: 0001193125-25-283329
Chunk: 2

Company: Scilex Holding Co
Filing Date: 2025-11-14
Form: 424B3
Chunk 2
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 OF THE SECURITIES EXCHANGE ACT OF 1934 |

For the quarterly period ended: September 30, 2025

| ☐ | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 |

For the transition period from to Commission File Number 001-39852 Scilex Holding Company (Exact Name of Registrant as Specified in Its Charter)

| Delaware                                                      |                         92-1062542 |
| (State or Other Jurisdiction ofIncorporation or Organization) | -I.R.S. EmployerIdentification No. |
| 960 San Antonio RoadPalo Alto, CA                             |                              94303 |
| (Address of Principal Executive Offices)                      |                          -Zip Code |

(650) 516-4310 (Registrant’s telephone number, including area code) Securities registered pursuant to Section 12(b) of the Act:

| Title of each class                                                         |     | TradingSymbol(s) |     | Name of exchange on which registered |
| Common Stock, par value $0.0001 per share                                   |     | SCLX             |     | The Nasdaq Stock Market LLC          |
| Warrants to purchase common stock at an exercise price of $402.50 per share |     | SCLXW            |     | The Nasdaq Stock Market LLC          |

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. ☒ Yes ☐ No Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (Section 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). ☒ Yes ☐ No Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in