Company: GHRS
Filing Date: 2025-02-05
Form Type: 424B5
Source: 0001140361-25-003183
Chunk: 0

Company: GH Research PLC
Filing Date: 2025-02-05
Form: 424B5
Chunk 0
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TABLE OF CONTENTS

Filed Pursuant to Rule 424(b)(5) Registration No.333-270418 PROSPECTUS SUPPLEMENT (to Prospectus dated March 17, 2023) 10,000,000 Ordinary Shares GH Research PLC We are offering 10,000,000 ordinary shares, nominal value $0.025 per share. The public offering price is $15.00 per share. Our ordinary shares are listed on the Nasdaq Global Market, or Nasdaq, under the symbol “GHRS”. On February 4, 2025, the last reported sale price of our ordinary shares on Nasdaq was $16.32 per share. Investing in our ordinary shares involves risks. See the section titled “Risk Factors” on page S- 8of this prospectus supplement and in the documents we incorporate by reference herein.

|                                           |     |    Per 
  Share |     |        Total |
| Public offering price                     |     | $15.00 |     | $150,000,000 |
| Underwriting discounts and commissions(1) |     |  $0.90 |     |   $9,000,000 |
| Proceeds, before expenses, to us          |     | $14.10 |     | $141,000,000 |

| (1) | See “Underwriting” for a description of the compensation payable to the underwriters. |

We have granted the underwriters a 30-day option to purchase up to 1,500,000 additional ordinary shares from us at the public offering price, less underwriting discounts and commissions. Neither the Securities and Exchange Commission nor any state or other securities commission, has approved or disapproved of our securities or passed upon the adequacy or accuracy of this prospectus supplement. Any representation to the contrary is a criminal offense. The ordinary shares are expected to be delivered to purchasers on or about February 6, 2025. Joint Book-Running Managers

| Cantor |     | Stifel |     | RBC Capital Markets |

Co-Lead Managers

| Canaccord Genuity |     | Citizens JMP |

The date of this prospectus supplement is February 4, 2025

TABLE OF CONTENTS

TABLE OF CONTENTS PROSPECTUS SUPPLEMENT

|                                                           |     | Page |
| About This Prospectus Supplement                          |     | S-1  |
| Prospectus Supplement Summary                             |     | S-3  |
| The Offering                                              |     |