Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 1

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 1
---
 (as defined below), or be cumulative, and we will have no obligation to pay any dividend for that dividend period to the holders of Series B Preferred Stock, including the depositary, and no related distribution will be made on the depositary shares, whether or not our board of directors or a duly authorized committee of our board of directors declares a dividend on the Series B Preferred Stock for any future dividend period. We may redeem the Series B Preferred Stock at our option:

| • |     | in whole or in part, from time to time, on any dividend payment date on or after the First Reset Date (as defined                                                                             
 below) at a redemption price equal to $1,000 per share (equivalent to $25 per depositary share), plus any declared and unpaid dividends, without accumulation of any undeclared dividends; or |

| • |     | in whole but not in part, at any time within 90 days following a regulatory capital treatment event (as defined                                                                              
 herein), at a redemption price equal to $1,000 per share (equivalent to $25 per depositary share), plus any declared and unpaid dividends, without accumulation of any undeclared dividends. |

The Series B Preferred Stock will not have any voting rights, except as set forth under “Description of the Series B Preferred Stock—Voting Rights” on page S-27. Neither the depositary shares nor the Series B Preferred Stock will be insured by the Federal Deposit Insurance Corporation (the “FDIC”) or any other governmental agency or instrumentality. Neither the depositary shares nor the Series B Preferred Stock will be savings accounts, deposits or other obligations of any bank. We intend to apply to list the depositary shares on the New York Stock Exchange (the “NYSE”) under the symbol “CMA PrB.” If approved for listing, we expect trading of the depositary shares on the NYSE to commence within 30 days after we issue the depositary shares. Investing in the depositary shares involves risks. See “ Risk Factors” beginning on page S-12and the risk factors in the documents incorporated by reference in this prospectus supplement and the accompanying prospectus to read about factors you should consider before buying the depositary shares. Neither the Securities and Exchange Commission (“SEC”) nor any state securities commission has approved or disapproved of the depositary shares or passed upon the adequacy or accuracy of this prospectus supplement or the accompanying prospectus. Any representation to the contrary is a criminal offense.

|                           |     | Per Depositary