Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 25

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 25
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 securities analysts, the market 
 price of our securities may decline.                                                                           |

| • |     | We are an emerging growth company, and we cannot be certain if the reduced reporting requirements applicable to 
 emerging growth companies will make our Common Stock less attractive to investors.                              |

Risks Related to Cryptocurrency

| • |     | Our cryptocurrency treasury strategy has not been implemented or tested. |

| • |     | Absent federal regulations, there is a possibility that certain cryptocurrencies may be classified as                                                                                                                  
 “securities” or be determined to be offered and sold as a “security.” Any such classification of a cryptocurrency would subject us to additional regulation and could materially impact the operation of our business. |

| • |     | If we were deemed to be an investment company under the 1940 Act, applicable restrictions likely would make it 
 impractical for us to continue segments of our business as currently contemplated.                             |

Corporate Information We were incorporated under the name “Vickers Vantage Corp. I” on February 21, 2020 as a Cayman Islands exempted company for the purpose of effecting a merger, share exchange, asset acquisition, share purchase, reorganization or similar business combination with one or more businesses or entities. On November 9, 2022, we changed our jurisdiction of incorporation by deregistering as a Cayman Islands exempted company and continuing and domesticating as a corporation incorporated under the laws of the State of Delaware. On November 9, 2022, we changed our name to “Scilex Holding Company.” Our principal executive offices are located at 960 San Antonio Road, Palo Alto, California 94303, and our telephone number is (650) 516-4310.Our website address is www.scilexholding.com. Any information contained on, or that can be accessed through, our website is not incorporated by reference into, nor is it in any way part of this prospectus and should not be relied upon in connection with making any decision with respect to an investment in our securities. We are required to file annual, quarterly and current reports, proxy statements and other information with the SEC. You may obtain any of the documents filed by us with the SEC at no cost from the SEC’s website at http://www.sec.gov.

16

THE OFFERING Issuance of Common Stock by Us

| The Warrant Exchange | Pursuant to the Warrant Exchange Agreements, the Company and the Tranche B Investors, in reliance on Section 3(a)(