Company: LENZ
Filing Date: 2025-04-14
Form Type: 424B5
Source: 0001628280-25-017695
Chunk: 2

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-14
Form: 424B5
Chunk 2
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 | Page |
| About this Prospectus               |     |   ii |
| Prospectus Summary                  |     |    1 |
| Risk Factors                        |     |    4 |
| Forward‑Looking Statements          |     |    5 |
| Use of Proceeds                     |     |    6 |
| Description of Capital Stock        |     |    7 |
| Description of Debt Securities      |     |    8 |
| Description of Depositary Shares    |     |   16 |
| Description of Warrants             |     |   19 |
| Description of Subscription Rights  |     |   20 |
| Description of Purchase Contracts   |     |   21 |
| Description of Units                |     |   22 |
| Plan of Distribution                |     |   23 |
| Legal Matters                       |     |   25 |
| Experts                             |     |   25 |
| Where You Can Find More Information |     |   25 |
| Incorporation by Reference          |     |   26 |

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### ABOUT THIS PROSPECTUS SUPPLEMENT
This prospectus supplement is part of a shelf registration statement on Form S-3 that we filed with the Securities and Exchange Commission (the “SEC”). Under this shelf registration process, we may sell any combination of the securities described in our base prospectus included in the shelf registration statement in one or more offerings up to a total aggregate offering price of $500,000,000. The $150,000,000 of common stock that may be offered, issued and sold under this prospectus is included in the $500,000,000 of securities that may be offered, issued and sold by us pursuant to our shelf registration statement.

You should rely only on the information contained in, or incorporated by reference into, this prospectus supplement, the accompanying prospectus and in any free writing prospectus that we may authorize for use in connection with this offering. We have not, and TD Cowen has not, authorized any other person to provide you with different or additional information. If anyone provides you with different or inconsistent information, you should not rely on it. We are not, and TD Cowen is not, making an offer to sell or soliciting an offer to buy our securities in any jurisdiction in which an offer or solicitation is not authorized or in which the person making that offer or solicitation is not qualified to do so or to anyone to whom it is unlawful to make an