Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 105

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 105
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 gross proceeds from the sale of the securities to investors in this offering. The following table shows the per share and total cash Placement Agent fees we will pay to the placement agent in connection with the sale of the securities offered pursuant to this registration statement and the accompanying prospectus.

|                                  |     | Per ADS and  
 Accompanying 
 Warrants     |     | Per          
 Pre-Funded   
 Warrant and  
 Accompanying 
 Warrants     |     | Total |
|:---------------------------------|:----|:-------------|:----|:-------------|:----|:------|
| Public Offering Price            |     | $            |     | $            |     | $     |
| Placement Agent Fees             |     | $            |     | $            |     | $     |
| Proceeds to Us (before expenses) |     | $            |     | $            |     | $     |

We have also agreed to reimburse the Placement Agent for (i) certain of its offering-related expenses, including for its legal fees and expenses and other out-of-pocketexpenses in an amount up to $125,000, and (ii) certain non-accountableexpenses in an amount up to $10,000. 69

We estimate the total expenses of this offering payable by us, excluding the Placement
Agent’s fees, will be approximately $ .

Warrant Solicitation Fee

Upon any exercise of the Series B Warrants via the “zero exercise price” option, we have agreed to pay the Placement Agent a
cash fee equal to 5.0% of the aggregate gross proceeds received from the Mandatory Nominal Exercise Price of the Series B Warrants, or £0.01 per ADS, up to a total maximum fee of $230,000 in accordance with the Financial Industry
Regulatory Authority, or FINRA, Rule 5110(g)(10).

Lock-upAgreements

We and each of our officers and directors have agreed with the Placement Agent to be subject to a
lock-up period of ninety (90) days following the date of closing of the offering pursuant to this prospectus. This means that, during the applicable lock-up period,
we may not issue, enter into any agreement to issue or announce the issuance or proposed issuance of any ADSs, ordinary shares or ordinary share equivalents, file any registration statement or amendment or supplement, or effect or enter into an
agreement to effect any issuance by us of ADSs, ordinary shares or ordinary share equivalents (as defined in the securities purchase agreement)