Company: RGNX
Filing Date: 2025-06-13
Form Type: S-3
Source: 0001193125-25-140870
Chunk: 3

Company: REGENXBIO Inc.
Filing Date: 2025-06-13
Form: S-3
Chunk 3
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 consider the risks we describe in this prospectus and in any accompanying prospectus supplement, as well as the risk factors that are incorporated by reference into this prospectus and in any accompanying prospectus supplement from our filings made with the Securities and Exchange Commission. See “ Risk Factors” beginning on page 3 of this prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

The date of this prospectus is , 2025

TABLE OF CONTENTS

| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     | ii |
| ABOUT THIS PROSPECTUS                             |     |  1 |
| THE COMPANY                                       |     |  2 |
| RISK FACTORS                                      |     |  3 |
| USE OF PROCEEDS                                   |     |  4 |
| DESCRIPTION OF COMMON STOCK                       |     |  5 |
| THE SELLING STOCKHOLDER                           |     | 10 |
| PLAN OF DISTRIBUTION                              |     | 11 |
| LEGAL MATTERS                                     |     | 14 |
| EXPERTS                                           |     | 14 |
| WHERE YOU CAN FIND MORE INFORMATION               |     | 14 |

i

SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS This prospectus, each prospectus supplement and the information incorporated by reference in this prospectus contains “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), which are subject to the safe harbor created by those sections for such statements. These statements express a belief, expectation or intention, and are generally accompanied by words that convey projected future events or outcomes such as “anticipate,” “assume,” “believe,” “continue,” “could,” “design,” “estimate,” “expect,” “forecast,” “goal,” “intend,” “may,” “objective,” “plan,” “position,” “potential,” “predict,” “project,” “seek,” “should,” “will,” “would” or variations of such words or by similar expressions. We have based these forward-looking statements on our current expectations, estimates and assumptions and analyses in light of our experience and our perception of historical trends, current conditions and expected future developments, as