Company: XOMAP
Filing Date: 2025-10-03
Form Type: 424B5
Source: 0001193125-25-230383
Chunk: 33

Company: XOMA Royalty Corp
Filing Date: 2025-10-03
Form: 424B5
Chunk 33
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 accompanying prospectus. Information in this prospectus supplement supersedes information incorporated by reference that we filed with the SEC prior to the date of this prospectus supplement, while information that we file later with the SEC will automatically update and supersede this information. We are incorporating by reference the documents listed below:

| • |     | the description of our capital stock included under the caption “Description of Capital Stock” in                                                                                 
 the prospectus dated December 16, 2011, which was filed on December 19, 2011, and is part of our registration statement on                                                        
 Form S-4/A filed on December 13, 2011 (Registration                                                                                                                               
 no. 333-177165),                                                                                                                                                                  
 including any amendment or report filed for the purpose of updating such description, including Exhibit 4.10 to our Annual Report on Form 10-K for the fiscal year ended December 
 31, 2024, filed with the SEC on March 17, 2025;                                                                                                                                   |

We also incorporate by reference any filings (other than current reports on Form 8-Kfurnished under Item 2.02 or Item 7.01, exhibits filed on such form that are related to such items unless such Form 8-Kexpressly provides to the contrary and certain exhibits furnished pursuant to Item 9.01 of Form 8-K) made with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this prospectus supplement but before the termination of the offering covered by this prospectus supplement. We have not authorized anyone to provide you with any different or additional information other than that contained in or incorporated by reference into this prospectus supplement and the accompanying prospectus. We take no responsibility for, and can provide no assurance as to the reliability of, any information that others may provide. Any statement contained in a document incorporated or deemed to be incorporated by reference into this prospectus supplement or the accompanying prospectus will be deemed to be modified or superseded for purposes of this prospectus supplement to the extent that a statement contained in this prospectus supplement or any other subsequently filed document that is deemed to be incorporated by reference into this prospectus supplement modifies or supersedes the statement. Any statement so modified or superseded will not be deemed, except as so modified or superseded, to constitute a part of this prospectus supplement. S-28

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