Company: AZN
Filing Date: 2025-06-26
Form Type: 11-K
Source: 0001683168-25-004771
Chunk: 4

Company: ASTRAZENECA PLC
Filing Date: 2025-06-26
Form: 11-K
Chunk 4
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 able to make new investments in, or transfer funds to the ADRs on or after December 15, 2015.

The AstraZeneca
Investment Committee is the Plan’s named fiduciary for investment and certain administrative duties, and the AstraZeneca Administration
Committee is the Plan’s named fiduciary for claims administration and ce1tain other duties. Both committees are appointed by and
subject to review by the AstraZeneca North America HR Sub-Committee. The Company has contracted with Fidelity Workplace Services LLC
to act as recordkeeper for the Plan.

Some costs and
expenses incident to the administration of the Plan and the management of the trust, including the compensation of the trustee, are paid
by the Company. Brokerage charges and fees incurred in connection with the purchase and sale of securities are included as an element
of the cost of securities purchased or as a reduction in the proceeds of securities sold. Investment advisory fees are paid by the Company.
Administrative expenses included in the statement of changes in net assets available for benefits relate to participant distribution mailings
and short-term trading fees applicable to certain investment options. These amounts are paid by the Plan, as a reduction from the participants
account.

Contributions:

Participants
can make before-tax or after-tax (including ROTH) contributions of up to 50% of annual eligible compensation. The maximum amount of the
Company match is one dollar for each dollar of the first 6% of eligible compensation that a participant contributes to the Plan. Participants
age 50 and over are eligible to contribute additional before-tax and ROTH contributions (“catch-up contributions”) above the
annual Internal Revenue Service (“IRS”) limitations up to $7,500 in 2024. The contribution limit for participants is $23,000
and the limitation on benefits and contributions under Section 415(c)(l)(A) of the Internal Revenue Code is $69,000 in 2024.

| 6 |

<div align='center'>ASTRAZENECA SAVINGS AND SECURITY PLAN

Notes to Financial Statements

December 31, 2024 and 2023

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| 1. | Description of   
 Plan, continued: |

Certain
employees of the Company are eligible to receive “AZ Retirement Company Contributions.” A participant’s employer contribution
is equal to a specified percentage of a participant’s eligible compensation for the Plan year, based on a participant’s points.
Participant’s points are calculated as the aggregate age and