Company: SHPH
Filing Date: 2025-02-27
Form Type: 424B3
Source: 0001493152-25-008478
Chunk: 59

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-02-27
Form: 424B3
Chunk 59
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 ● | the                                                                                                                               
 concentrated ownership of our common stock;                                                                                       |
| ● | changes                                                                                                                           
 in accounting principles;                                                                                                         |
| ● | terrorist                                                                                                                         
 acts, acts of war or periods of widespread civil unrest;                                                                          |
| ● | natural                                                                                                                           
 disasters and other calamities; and                                                                                               |
| ● | general                                                                                                                           
 economic, industry and market conditions.                                                                                         |

In addition, the stock markets in general, and the markets for pharmaceutical stocks, in particular, have experienced extreme volatility that has been often unrelated to the operating performance of the issuer. These broad market and industry factors may seriously harm the market price of our common stock, regardless of our operating performance.

The future issuance of equity or of debt securities that are convertible into common stock will dilute our share capital.

We may choose to raise additional capital in the future, depending on market conditions, strategic considerations and operational requirements. To the extent that additional capital is raised through the issuance of shares or other securities convertible into shares of our common stock, our stockholders will be diluted. Future issuances of our common stock or other equity securities, or the perception that such sales may occur, could adversely affect the trading price of our common stock and impair our ability to raise capital through future offerings of shares or equity securities. No prediction can be made as to the effect, if any, that future sales of common stock or the availability of common stock for future sales will have on the trading price of our common stock.

If we fail to maintain applicable listing requirements, Nasdaq may delist our common stock from trading, in which case the liquidity and market price of our common stock could decline.

We cannot assure you that we will be able to meet the continued listing standards of Nasdaq in the future. If we fail to comply with the applicable listing standards, including the requirement that we regain compliance with the $2.5 million stockholders’ equity requirement and the Minimum Bid Price Requirement, and Nasdaq delists our common stock, we and our stockholders could face significant material adverse consequences, including:

| ● | a                                                                                                                                
 limited availability of market quotations for shares of our common stock;                                                        |
| ● | reduced                                                                                                                          
 liquidity for our common stock;                                                                                                  |
| ● | a                                                                                                                                
 determination that our common stock is “penny stock,” which would require brokers trading in our common stock to adhere          
 to more stringent rules and possibly result in a reduced level of trading activity in the secondary trading market for shares of 
 our common