Company: PSTV
Filing Date: 2025-04-04
Form Type: S-3
Source: 0001193125-25-073481
Chunk: 22

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-04
Form: S-3
Chunk 22
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 time of sale, at prices related to the prevailing market price, at varying prices determined at the time of sale, or at negotiated prices. The selling stockholders may use any one or more of the following methods when disposing of their shares of common stock or interests therein:

| • |     | on any national securities exchange or quotation service on which the shares of common stock may be listed or 
 quoted at the time of sale;                                                                                   |

| • |     | in the over-the-counter market; |

| • |     | ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers; |

| • |     | block trades in which the broker-dealer will attempt to sell the shares of common stock as agent but may position 
 and resell a portion of the block as principal to facilitate the transaction;                                     |

| • |     | through brokers, dealers or underwriters that may act solely as agents; |

| • |     | purchases by a broker-dealer as principal and resale by the broker-dealer for its account; |

| • |     | an exchange distribution in accordance with the rules of the applicable exchange; |

| • |     | privately negotiated transactions; |

| • |     | delivery of shares in settlement of short sales; |

| • |     | in transactions through broker-dealers that agree with the selling stockholders to sell a specified number of 
 such shares of common stock at a stipulated price per security;                                               |

| • |     | through the writing or settlement of options or other hedging transactions, whether through an options exchange 
 or otherwise;                                                                                                   |

| • |     | a combination of any such methods of disposition; or |

| • |     | any other method permitted pursuant to applicable law. |

The selling stockholders may also sell the shares of common stock under Rule 144 or any other exemption from registration under the Securities Act, if available, rather than under this prospectus. Broker-dealers engaged by the selling stockholders may arrange for other brokers-dealers to participate in sales. Broker-dealers, underwriters and other agents may receive commissions or discounts from the selling stockholders (or, if any broker-dealer acts as agent for the purchaser of shares of common stock, from the purchaser) in amounts to be negotiated, but, except as set forth in a supplement to this prospectus, in the case of an agency transaction not in excess of a customary brokerage commission in compliance with Financial Industry Regulatory Authority (“FINRA”) Rule 2121, and in