Company: CYTK
Filing Date: 2025-08-07
Form Type: S-8
Source: 0001193125-25-175412
Chunk: 1

Company: CYTOKINETICS INC
Filing Date: 2025-08-07
Form: S-8
Chunk 1
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 Securities and Exchange Commission (the “SEC”) on May 4, 2004(File No. 333-115146), June 20, 2005(File No. 333-125973), April 14, 2006(File No. 333-133323), February 28, 2007(File No. 333-140963), March 14, 2008(File No. 333-149713), August 7, 2008(File No. 333-152850), August 6, 2009(File No. 333-161116), August 4, 2010(File No. 333-168520), August 5, 2011(File No. 333-176089), August 6, 2012(File No. 333-183091), August 7, 2013(File No. 333-190458), August 5, 2015(File No. 333-206101), November 3, 2017(File No. 333-221348), March 4, 2020(File No. 333-236889), May 29, 2020(File No. 333-238786), May 13, 2021(File No. 333-256054), November 5, 2021(File No. 333-260840), May 31, 2022(File No. 333-265316),and March 1, 2023(File No. 333-270182),(collectively, the “Prior Registration Statements”). This Registration Statement on Form S-8relates to securities of the same class as that to which the Prior Registration Statements relate, and is submitted in accordance with General Instruction E to Form S-8regarding Registration of Additional Securities. Pursuant to General Instruction E of Form S-8,the contents of the Prior Registration Statements, to the extent relating to the registration of Common Stock issuable under the EIP are incorporated herein by reference and made part of this Registration Statement, except as amended hereby. ITEM 8. EXHIBITS

| Exhibit 
 Number  |     | Description                                                                    |
| 4.1(1)  |     | Amended and Restated Certificate of Incorporation.                             |
| 4.2(2)  |     | Amended and Restated Bylaws.                                                   |
| 4.3(3)  |     | Certificate of Amendment of Amended and Restated Certificate