Company: AZN
Filing Date: 2025-11-17
Form Type: 6-K
Source: 0001654954-25-013129
Chunk: 0

Company: ASTRAZENECA PLC
Filing Date: 2025-11-17
Form: 6-K
Chunk 0
---
#### FORM 6-K
<div align='center'>SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Report of Foreign Issuer

Pursuant to Rule 13a-16 or 15d-16 of

the Securities Exchange Act of 1934

For the month of November 2025

Commission File Number: 001-11960</div>

#### AstraZeneca PLC
<div align='center'>1 Francis Crick Avenue

Cambridge Biomedical Campus

Cambridge CB2 0AA

United Kingdom

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F X Form 40-F __

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ______

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes __ No X

If “Yes” is marked, indicate below the file number assigned to the Registrant in connection with Rule 12g3-2(b): 82-_____________</div>

#### AstraZeneca PLC
<div align='center'>INDEX TO EXHIBITS</div>

#### 1.

#### Holding(s) in Company
<div align='center'>TR-1: Standard form for notification of major holdings</div>

#### 1. Issuer Details

#### ISIN
| GB0009895292 |

#### Issuer Name
| ASTRAZENECA PLC |

#### UK or Non-UK Issuer
| UK |

#### 2. Reason for Notification
| An acquisition or disposal of voting rights |

**3. Details of person subject to the notification obligation**

#### Name
| The Capital Group Companies, Inc. |

#### City of registered office (if applicable)
| Los Angeles |

#### Country of registered office (if applicable)
| USA |

#### 4. Details of the shareholder
**Full name of shareholder(s) if different from the person(s) subject to the notification obligation, above**

#### City of registered office (if applicable