Company: TVRD
Filing Date: 2025-01-27
Form Type: S-4/A
Source: 0001104659-25-006050
Chunk: 0

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-01-27
Form: S-4/A
Chunk 0
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As filed with the Securities and Exchange Commission on January 24, 2025 Registration No. 333-283900 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-4 REGISTRATION STATEMENT Under The Securities Act of 1933 CARA THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter)

| Delaware                        |   |                         2834 |   | 75-3175693            |
| (State or Other Jurisdiction of 
 Incorporation or Organization)  | ​ | -Primary Standard Industrial 
   Classification Code Number | ​ | -I.R.S. Employer      
 Identification Number |

400 Atlantic Street Suite 500 Stamford, CT 06901 (203) 406-3700 (Address, including zip code, and telephone number, including area code, of Registrant’s principal executive offices) Christopher Posner Chief Executive Officer Cara Therapeutics, Inc. 400 Atlantic Street Suite 500 Stamford, CT 06901 (203) 406-3700 (Name, address, including zip code, and telephone number, including area code, of agent for service) Please send copies of all communications to:

| Daniel A. Bagliebter    
 Jeffrey P. Schultz      
 Kenneth R. Koch         
 Mintz Levin Cohn Ferris 
 Glovsky and Popeo, P.C. 
 919 Third Avenue        
 New York, NY 10022      
 (212) 935-3000          |     | Scott Terrillion        
 General Counsel         
 Cara Therapeutics, Inc. 
 400 Atlantic Street     
 Suite 500               
 Stamford, CT 06901      
 (203) 406-3700          |     | Divakar Gupta      
 Carlos Ramirez     
 Rama Padmanabhan   
 Anitha Anne        
 Cooley LLP         
 55 Hudson Yards    
 New York, NY 10001 
 (212) 479-6000     |

Approximate date of commencement of proposed sale to the public: As soon as practicable after the effectiveness of this registration statement and the satisfaction or waiver of all other conditions under the Merger Agreement described herein. If the securities being registered on this Form are being offered in connection with the formation of a holding company and there is compliance with General Instruction G, please check the following box. ☐ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the