Company: MIRA
Filing Date: 2025-06-17
Form Type: PREM14A
Source: 0001641172-25-015340
Chunk: 170

Company: MIRA PHARMACEUTICALS, INC.
Filing Date: 2025-06-17
Form: PREM14A
Chunk 170
---
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3 https://www.tobaccoinduceddiseases.org/Enhancing-nicotine-replacement-therapy-usage-and-nadherence-through-a-mobile-intervention,120076,0,2.html

4 https://genderdata.worldbank.org/en/indicator/sh-sta-owad-zs?gender=total

| Moore Financial Consulting |

| SKNY Pharmaceuticals, Inc. | April 2025    |
| Valuation                  | Page 10 of 25 |

Within North America, Mexico and the US have the highest overweight and obesity rates (75% and 73.6% respectively), followed by Canada (65.7%)

Being overweight is a condition caused by excessive fat deposits. Obesity is a chronic, complex disease defined by excessive fat deposits that can impair health. Obesity is typically assessed using the Body Mass Index (BMI), calculated by dividing a person’s weight in kilograms by the square of their height in meters. The classifications are:

| ● | Overweight: 
 BMI ≥ 25    |

| ● | Obesity: 
 BMI ≥ 30 |

Several factors contribute to the development of obesity, including:

| ● | Excessive                                                    
 calorie intake: Consuming more calories than the body needs. |

| ● | Sedentary                             
 lifestyle: Lack of physical activity. |

| ● | Genetic                                    
 predisposition: Family history of obesity. |

| ● | Endocrine                                                
 and metabolic disorders: Conditions like hypothyroidism. |

| ● | Psychological                                      
 factors: Stress, depression, and emotional eating. |

| ● | Medications:                           
 Certain drugs can lead to weight gain. |

Obesity significantly increases the risk of various health issues, such as:

| ● | Type       
 2 diabetes |

| ● | Cardiovascular                                
 diseases: Including heart disease and stroke. |

| ● | Hypertension |

| ● | Certain                                                  
 cancers, Such as breast, colon, and endometrial cancers. |

| ● | Sleep 
 apnea |

| ● | Osteoarthritis |

| ● | Fatty         
 liver disease |

| ● | Mental                                              
 health disorders: Including depression and anxiety. |

Obesity is associated with approximately 5 million deaths annually 1. It is a leading cause of preventable death, particularly in developed countries. Economically, obesity imposes a substantial burden. For example, the United States spends around $173 billion annuallyon obesity-related healthcare costs, not accounting for indirect costs like lost productivity.

The global weight