Company: BCS
Filing Date: 2025-08-06
Form Type: 424B2
Source: 0001193125-25-174548
Chunk: 71

Company: BARCLAYS PLC
Filing Date: 2025-08-06
Form: 424B2
Chunk 71
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, Luxembourg). The CUSIP and ISIN for each series of notes is:

|                     |     | CUSIP |            |     | ISIN |              |     | Common Code |           |
| 2029 notes          |     |       | 06738E DD4 |     |      | US06738EDD40 |     |             | 314818601 |
| 2046 notes          |     |       | 06738E DE2 |     |      | US06738EDE23 |     |             | 314818083 |
| Floating rate notes |     |       | 06738E DF9 |     |      | US06738EDF97 |     |             | 314818458 |

S-63

Certain of the underwriters may not be U.S. registered broker-dealers and accordingly will
not effect any sales within the United States except in compliance with applicable U.S. laws and regulations, including the rules of FINRA.

Certain of the underwriters and their affiliates have performed investment banking and advisory services for us from time to time for which
they have received customary fees and expenses. The underwriters and their affiliates may from time to time engage in transactions with and perform services for us in the ordinary course of business.

It is expected that delivery of the notes will be made, against payment for the notes, on or about August 11, 2025, which will be the fifth
(5th) business day in the United States following the date of pricing of the notes. Under Rule 15c6-1 under the Securities Exchange Act of 1934, purchases or sales of securities in the secondary market
generally are required to settle within one business day (T+1), unless the parties to any such transaction expressly agree otherwise. Accordingly, purchasers who wish to trade the notes on any day prior to the business day before delivery will be
required, by virtue of the fact that the notes initially will not settle on T+1 in the United States, to specify any alternate settlement cycle at the time of any such trade to prevent a failed settlement. Purchasers of the notes who wish to make
such trades should consult their own advisors.

Conflicts of Interest

Barclays Capital Inc., the Sole Structuring Adviser and Sole Bookrunner, is an affiliate of Barclays PLC and, as such, is deemed to have a
“conflict of interest” in this offering within the meaning of Rule 5121 (or any