Company: XXII
Filing Date: 2025-11-04
Form Type: 424B5
Source: 0001493152-25-020754
Chunk: 7

Company: 22nd Century Group, Inc.
Filing Date: 2025-11-04
Form: 424B5
Chunk 7
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 portfolio comprising issued patents and patent applications related to tobacco plants, and in particular our reduced nicotine tobacco plants.

In addition to continued focus on VLN ®, we renewed our focus on utilizing our tobacco assets to attract additional tobacco business to help fund the growth of VLN ®. In addition to existing business relationships with multiple tobacco products companies, we will continue to expand the number of brands in our contract manufacturing operations (“CMO”) portfolio in 2025.

Our Annual Report on Form 10-K for the year ended December 31, 2024, as amended, and the subsequent reports filed pursuant to the Exchange Act provide additional information about our business, operations and financial condition.

June 2025 Reverse Stock Split

On June 16, 2025, we filed a Certificate of Change pursuant to NRS Section 78.209 with the Secretary of State of the State of Nevada authorizing the Reverse Stock Split. The Reverse Stock Split became effective at 12:01 a.m. Eastern Time on June 20, 2025, and was reflected with NASDAQ and in the marketplace at the open of business on June 20, 2025, whereupon the shares of common stock began trading on a split-adjusted basis. All share and per share information in this prospectus supplement has been adjusted to reflect the Reverse Stock Split, however, may not have been adjusted in the information and documents incorporated by reference to this prospectus supplement and accompanying prospectus prior to June 20, 2025.

July 2025 Charter Amendment

On July 15, 2025, our stockholders approved
an amendment (the “Amendment”) to our Articles of Incorporation, as amended, to increase the number of authorized shares
of common stock from two hundred fifty million (250,000,000) to five hundred million (500,000,000), which Amendment was filed and effective
with the Secretary of the State of Nevada on July 15, 2025.

Corporate Information

We are a Nevada corporation and our corporate headquarters is located at 321 Farmington Road, Mocksville, North Carolina 27028. Our telephone number is (336) 940-3769. Our internet address is www.xxiicentury.com. We do not incorporate the information on our website into this prospectus supplement or in the accompanying prospectus, and you should not consider it to be a part of this prospectus supplement or the accompanying prospectus. Our web site address is included as an inactive textual reference only.