Company: GANX
Filing Date: 2025-11-07
Form Type: S-3/A
Source: 0001104659-25-108472
Chunk: 0

Company: Gain Therapeutics, Inc.
Filing Date: 2025-11-07
Form: S-3/A
Chunk 0
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TABLE OF CONTENTS

As filed with the Securities and Exchange Commission on November 7, 2025 Registration No. 333-287622 UNITED STATES
SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 AMENDMENT NO. 1 TO FORM S-3
REGISTRATION STATEMENT UNDER
THE SECURITIES ACT OF 1933 GAIN THERAPEUTICS, INC. (Exact name of registrant as specified in its charter)

| ​ | Delaware                                                       
 (State or other jurisdiction ofincorporation or organization)​ | ​ | ​ | 85-1726310                             
 (I.R.S. EmployerIdentification Number) | ​ |

Gain Therapeutics, Inc.
4800 Montgomery Lane, Suite 220
Bethesda, Maryland 20814
(301) 500-1556 (Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices) Gene Mack
Chief Executive Officer
Gain Therapeutics, Inc.
4800 Montgomery Lane, Suite 220
Bethesda, Maryland 20814
(301) 500-1556 (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies of all communications, including communications sent to the agent for service, to: Steven M. Skolnick, Esq.
Daniel Porco, Esq.
Lowenstein Sandler LLP
1251 Avenue of the Americas
New York, New York 10020
Tel: (212) 262-6700 Approximate date of commencement of proposed sale to the public : From time to time after this registration statement becomes effective. If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: ☐ If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box: ☒ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number