Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 325

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 325
---
 extent they become applicable to us. Compensation Committee Our Compensation Committee consists of Dorman Followwill, Jay Chun, M.D., Ph.D. and Yue Alexander Wu, Ph.D., with Yue Alexander Wu, Ph.D. serving as the chairperson of the committee. Dorman Followwill, Jay Chun, M.D., Ph.D. and Yue Alexander Wu, Ph.D. each satisfy the independence requirements under the Nasdaq Listing Rules. Each of the members of the Compensation Committee is a non-employeedirector as defined in Rule 16b-3promulgated under the Exchange Act and satisfies Nasdaq independence requirements. The Compensation Committee acts on behalf of our Board to fulfill our Board’s responsibilities in overseeing our compensation policies, plans and programs, and in reviewing and determining the compensation to be paid to our executive officers and non-employeedirectors. The responsibilities of the Compensation Committee are included in its written charter. The Compensation Committee’s responsibilities include, among others:

| • |     | reviewing, modifying and approving (or, if it deems appropriate, making recommendations to our Board regarding)                                                                                                       
 our overall compensation strategy and policies, and reviewing, modifying and approving corporate performance goals and objectives relevant to the compensation of our executive officers and other senior management; |

| • |     | determining and approving (or, if it deems appropriate, recommending to our Board for determination and approval)                                                                                                                                  
 the compensation and terms of employment of our Chief Executive Officer, including seeking to achieve an appropriate level of risk and reward in determining the long-term incentive component of the compensation of the Chief Executive Officer; |

| • |     | determining and approving (or, if it deems appropriate, recommending to our Board for determination and approval) 
 the compensation and terms of employment of our executive officers and other members of senior management;        |

| • |     | reviewing and approving (or, if it deems appropriate, making recommendations to our Board regarding) the terms of                                                     
 employment agreements, severance agreements, change-of-control protections and other compensatory arrangements for our executive officers and other members of senior 
 management;                                                                                                                                                           |

208

| • |     | conducting periodic reviews of the base compensation levels of all of our employees generally; |

| • |     | reviewing and approving the type and amount of compensation to be paid or awarded to non-employee directors; |

| • |     | reviewing and approving the adoption, amendment and termination of our equity incentive plans, stock appreciation                                                                                                                                        
 rights plans, pension and profit sharing plans,