Company: PTHS
Filing Date: 2025-07-25
Form Type: S-8
Source: 0001753926-25-001183
Chunk: 0

Company: Pelthos Therapeutics Inc.
Filing Date: 2025-07-25
Form: S-8
Chunk 0
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<div align='center'>As filed with Securities and Exchange Commission on July 25, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT UNDER

THE SECURITIES ACT OF 1933

PELTHOS THERAPEUTICS INC.

(Exact name of registrant as specified in its charter)</div>

| Nevada                   |     | 86-3335449     |
| (State                   
 or other jurisdiction of |     | (I.R.S.        
 Employer       |
| incorporation            
 or organization)         |     | Identification 
 Number)        |

<div align='center'>4020 Stirrup Creek Drive
Suite 110
Durham, NC 27703

(877) 265-8266

Address, including zip code, and telephone number, including area code,

of registrant’s principal executive offices)

Pelthos Therapeutics Inc. Amended and Restated 2023 Equity Incentive Plan

(Full Title of the Plan)

Francis Knuettel II

Chief Financial Officer

4020 Stirrup Creek Drive
Suite 110
Durham, NC 27703
919-908-2450

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copy to:

David E. Danovitch, Esq.

Charles E. Chambers Jr., Esq.

Sullivan & Worcester LLP

1251 Avenue of the Americas, 19 thFloor

New York, NY 10020
(212) 660-3060</div>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer”, “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer | ☐ |     | Accelerated filer         | ☐ |
| Non-accelerated filer   | ☒ |     | Smaller reporting company | ☒ |
|                         |   |     | Emerging growth company   | ☒ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the