Company: ARWR
Filing Date: 2025-12-11
Form Type: S-3ASR
Source: 0001193125-25-314755
Chunk: 11

Company: ARROWHEAD PHARMACEUTICALS, INC.
Filing Date: 2025-12-11
Form: S-3ASR
Chunk 11
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 supplement for each series of debt securities that will describe:

| • |     | the title of the debt securities and whether the debt securities are senior, senior subordinated, or subordinated 
 debt securities;                                                                                                  |

| • |     | the aggregate principal amount of the debt securities being offered and any limit upon the aggregate principal                                                          
 amount of the series of debt securities, and, if the series is to be issued at a discount from its face amount, the method of computing the accretion of such discount; |

| • |     | the percentage of the principal amount at which debt securities will be issued and, if other than the full                                                                      
 principal amount thereof, the percentage of the principal amount of the debt securities that is payable if maturity of the debt securities is accelerated because of a default; |

| • |     | the date or dates, or the method for determining the date or dates, on which the principal of the debt securities 
 will be payable and the amount of principal that will be payable;                                                 |

| • |     | the rate or rates (which may be fixed or variable) at which the debt securities will bear interest, if any, or                                                                                                       
 the method of calculation of such rate or rates, as well as the dates from which interest will accrue, the dates on which interest will be payable and the record date for the interest payable on any payment date; |

| • |     | any collateral securing the performance of our obligations under the debt securities; |

| • |     | the currency or currencies (including any composite currency) in which principal, premium, if any, and interest,                                                                                                                                          
 if any, will be payable, and if such payments may be made in a currency other than that in which the debt securities are denominated, the manner for determining such payments, including the time and manner of determining the exchange rate between    
 the currency in which such securities are denominated and the currency in which such securities or any of them may be paid, and any additions to, modifications of or deletions from the terms of the debt securities to provide for or to facilitate the 
 issuance of debt securities denominated or payable in a currency other than U.S. dollars;                                                                                                                                                                 |

| • |     | the place or places where principal, premium, if any, and interest, if any, on the debt securities will be               
 payable and where debt securities that are in registered form can be presented for registration of transfer or exchange; |

| • |     | the denominations in which