Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 60

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 60
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 currency is not practical or lawful, or if any required approvals are denied or not obtainable at a reasonable cost or within a reasonable period, the depositary may take any of the following actions in its discretion:

| • |     | Convert the foreign currency to the extent practical and lawful and distribute the U.S. dollars to the ADS 
 holders for whom the conversion and distribution is lawful and practical.                                  |

| • |     | Distribute the foreign currency to ADS holders for whom the distribution is lawful and practical. |

| • |     | Hold the foreign currency (without liability for interest) for the applicable ADS holders. |

Governing Law/Waiver of Jury Trial The deposit agreement and the ADRs will be interpreted in accordance with the laws of the State of New York. The rights of holders of ordinary shares (including ordinary shares represented by ADSs) are governed by the laws of England and Wales. AS A PARTY TO THE DEPOSIT AGREEMENT, YOU IRREVOCABLY WAIVE, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, YOUR RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF THE DEPOSIT AGREEMENT AND/OR THE ADRs AGAINST US OR THE DEPOSITARY. 46

Confidential Treatment Requested by Nucana plc

Pursuant to 17 C.F.R. Section 200.83

DESCRIPTION OF SECURITIES WE ARE OFFERING

Series A Warrants

The following summary
of certain terms and provisions of the Series A Warrants that are being offered hereby is not complete and is subject to, and qualified in its entirety by, the provisions of the Series A Warrant, the form of which will be filed as an exhibit to the
registration statement of which this prospectus forms a part. Prospective investors should carefully review the terms and provisions of the form of Series A Warrant for a complete description of the terms and conditions of the Series A Warrants.

The following is a brief summary of the Series A Warrants and is still subject in all respects to the provisions contained in the form of
Series A Warrants.

Duration and Exercise Price

Each Series A Warrant will have an exercise price equal to $ per share, will become exercisable on the date of issuance and will
expire on the fifth anniversary of the date of issuance. The exercise price and number of ADSs issuable upon exercise is subject to appropriate adjustment in the event of share dividends, share splits, reorganizations