Company: GANX
Filing Date: 2025-07-15
Form Type: 424B5
Source: 0001104659-25-068103
Chunk: 77

Company: Gain Therapeutics, Inc.
Filing Date: 2025-07-15
Form: 424B5
Chunk 77
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) that are filed by us with the SEC pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (i) after the date of the initial filing of the registration statement of which this prospectus forms a part and prior to effectiveness of the registration statement, or (ii) after the date of this prospectus but prior to the termination of the offering. These documents include periodic reports, such as Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K, as well as proxy statements.

You can request a copy of these filings, at no cost, by writing or telephoning us at the following address or telephone number:

<div align='center'>Gain Therapeutics, Inc. 
 Attn: Corporate Secretary 
 4800 Montgomery Lane, Suite 220, 
 Bethesda, MD 20814 
 (301) 500-1556

31</div>

TABLE OF CONTENTS

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#### Shares of Common Stock
<div align='center'>**Pre-Funded Warrants to purchase up to Shares of Common Stock 
 Common Warrants to purchase up to Shares of Common Stock 
 Up to Shares of Common Stock Underlying the Pre-Funded Warrants 
 Up to Shares of Common Stock Underlying the Common Warrants**</div>

### PRELIMINARY PROSPECTUS SUPPLEMENT
<div align='center'>Sole Book-Running Manager</div>

#### Newbridge Securities Corporation

#### , 2025
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