Company: LIMN
Filing Date: 2025-08-13
Form Type: 424B3
Source: 0001410578-25-001746
Chunk: 143

Company: Liminatus Pharma, Inc.
Filing Date: 2025-08-13
Form: 424B3
Chunk 143
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 anti-mPD-1 mAb, but they survived over the experimental period and their body weight barely changed compared with that of rat IgG-treated mice. |

| ● | Anti-human CD47 mAb induces no/minimal inflammation in organs. |

| ● | C57BL/6-hCD47/hSIRPα mice were subcutaneously engrafted with MC38-hCD47 tumor cells and were repeatedly injected with Hu3A5-G4 mAb and/or anti-mPD-1 mAb. |

| ● | Lung, liver and kidney from each group of mice were collected 4th injection of Abs. H&E staining of organs showed that there was minimal or no inflammation in those organs. |

A 4-week Toxicity Study in Cynomolgus Monkeys Followed by a 4-Week Recovery Period

| ● | Objective of monkey toxicity study |

| ● | The objective of this study was to determine the potential toxicity of IBA101(Anti-CD47 mAb), a monoclonal antibody conjugated with IgG4 Fc, when administered as an intravenous bolus injection once weekly (Days 1, 8, 15, 22, and 29) to non-human primates and to evaluate the potential reversibility of any findings following a 4-Week recovery period. In addition, the toxicokinetic characteristics of IBA101(Anti-CD47 mAb) were determined. The study design was as follows: |

| ​         | ​ | ​               | ​ |           ​ | ​ |              ​ | ​ |             ​ | ​ |          ​ | ​ |       ​ | ​ |              ​ | ​ |       ​ |
| ​         |   |                 |   |             |   |                |   |               |   | Main Study |   |         | ​ | Recovery Study |   |         |
| ​         | ​ | ​               | ​ |           ​ | ​ |              ​ | ​ |          Dose | ​ |          ​ |   |       ​ |   |              ​ |   |       ​ |
| ​         | ​ | ​               | ​ |  Dose Level | ​ | Dose Volume(a) | ​ | Concentration | ​ |     No. of | ​ |  No. of | ​ |         No. of | ​ |  No. of |
| Group No. |   | Test Article    |   | -mg/kg/dose |   |