Company: XXII
Filing Date: 2025-08-26
Form Type: 424B5
Source: 0001641172-25-025541
Chunk: 24

Company: 22nd Century Group, Inc.
Filing Date: 2025-08-26
Form: 424B5
Chunk 24
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 necessarily are summaries of their material provisions and do not describe all provisions, exceptions and qualifications contained in those contracts, agreements or documents. You should read those contracts, agreements or documents for information that may be important to you. The registration statement, exhibits and schedules are available through its Internet website.

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<div align='center'>Incorporation of Certain Documents by Reference</div>

The SEC allows us to “incorporate by reference” much of the information we file with the SEC, which means that we can disclose important information to you by referring you to those publicly available documents. The information that we incorporate by reference in this prospectus supplement is considered to be part of this prospectus supplement. Because we are incorporating by reference future filings with the SEC, this prospectus supplement is continually updated and those future filings may modify or supersede some of the information included or incorporated in this prospectus supplement. This means that you must look at all of the SEC filings that we incorporate by reference to determine if any of the statements in this prospectus supplement or in any document previously incorporated by reference have been modified or superseded. This prospectus supplement incorporates by reference the documents listed below and any future filings we make with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (in each case, other than information furnished under Item 2.02 or Item 7.01 of Form 8-K) on or after the date of this prospectus supplement until the earlier of the date on which all of the securities registered hereunder have been sold or the registration statement of which this prospectus is a part has been withdrawn:

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 ● | Our                                                                                                                                  
 Annual Report on Form                                                                                                                
 10-K for the fiscal year ended December 31, 2024, filed with the SEC on March 20, 2025, as amended on Form 10-K/A on                 
 April 30, 2025;                                                                                                                      
 Our                                                                                                                                  
 Quarterly Reports on Form 10-Q filed with the SEC on May 13, 2025, and August 14, 2025;                                              |
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| ● | Our                                                                                                                                  
 Current Reports on Form 8-K filed with the SEC on January 7, 2025, January 13, 2025, January 27, 2025, April 30, 2025, May 22, 2025, 
 June 16,