Company: PRME
Filing Date: 2025-04-22
Form Type: DEF 14A
Source: 0001628280-25-018704
Chunk: 39

Company: Prime Medicine, Inc.
Filing Date: 2025-04-22
Form: DEF 14A
Chunk 39
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 the authority to engage the services of a consulting firm or other outside advisor to assist it in designing our executive compensation programs and in making compensation decisions.

During the fiscal year ended December 31, 2024, our compensation committee engaged Alpine Rewards to assist it in evaluating the Company’s executive and director compensation practices, including program design, identification of an appropriate peer group for compensation comparison purposes and providing pay benchmarking data. Alpine Rewards also provided (i) analysis and recommendations to our compensation committee regarding trends and emerging topics with respect to executive compensation; (ii) compensation programs for executives, directors and our employees generally; and (iii) stock utilization and related metrics. For further information, see “Corporate Governance – Compensation Committee – Compensation Consultant.”

Alpine reports directly to our compensation committee and did not provide any additional services other than as described below. Our compensation committee annually assesses its independence consistent with Nasdaq listing standards and concluded that the engagement of such consultant did not raise any conflict of interest.

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#### 2024 Base Salary
Our NEOs each receive a base salary to compensate them for services rendered to our Company. The base salary payable to each NEO is intended to provide a fixed component of compensation reflecting the executive’s skill set, experience, role and responsibilities. Base salaries may be adjusted from time to time to realign salaries with market levels after taking into account individual responsibilities, performance and experience. For the fiscal year ended December 31, 2024, the annual base salaries for our NEOs were as follows:

| Name                               |     | Base Salary from January 1, 2024 through March 1, 2024 (1) |     | Base Salary from March 1, 2024 through December 31, 2024 |
| Keith Gottesdiener, M.D.           |     |                                                   $625,000 |     |                                                 $658,350 |
| Allan Reine, M.D.                  |     |                                                   $500,000 |     |                                                 $500,000 |
| Jeremy Duffield, M.D., Ph.D., FRCP |     |                                                   $465,005 |     |                                                 $483,500 |

(1) Dr. Reine commenced employment with us on January 17, 2024, and his 2024 base salary was pro-rated accordingly.

#### 2024 Bonuses
2024 Annual Bonus

For the fiscal year ended December 31, 2024, each of the NEOs was eligible to