Company: SHPH
Filing Date: 2025-02-27
Form Type: 424B3
Source: 0001493152-25-008474
Chunk: 92

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-02-27
Form: 424B3
Chunk 92
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      4,970 |   |
| Change in fair value of marketable securities                    |     |                          |          — |   |     |      |     71,568 |   |
| Loss on settlement of convertible debt                           |     |                          |   (833,501 | ) |     |      |   (477,221 | ) |
| Total other income (expense)                                     |     |                          | (1,448,627 | ) |     |      |   (700,341 | ) |
| Net loss                                                         |     |                          | (9,144,797 | ) |     |      | (6,592,723 | ) |
| Weighted average common shares outstanding - basic               |     |                          |  2,870,120 |   |     |      |  1,866,275 |   |
| Net loss per shares - basic                                      |     | $                        |      (3.19 | ) |     | $    |      (3.53 | ) |
| Weighted average common shares outstanding - diluted             |     |                          |  2,887,268 |   |     | $    |  1,866,275 |   |
| Net loss per shares - diluted                                    |     | $                        |      (3.30 | ) |     | $    |      (3.53 | ) |

<div align='center'>The accompanying notes are an integral part of these consolidated financial statements.</div>

| F-3 |

<div align='center'>Shuttle Pharmaceuticals Holdings, Inc.

Consolidated Statements of Changes in Stockholders’ Equity

For the Years Ended December 31, 2024 and 2023</div>

|                                                                                               |     | Shares       
 Common Stock 
 Shares       |           |     | Amount 
 Amount |    |     | Capital    
 Additional 
 Paid-In    
 Capital    |            |   |     | Deficit     
 Accumulated 
 Deficit     |             |   |     | Equity        
 Total         
 Stockholders’ 
 Equity        |            |   |
|:----------------------------------------------------------------------------------------------|:----|:-------------|----------:|:----|:-------|---:|:----|:-----------|-----------:|:--|:----|:------------|:------------|:--|:----|:--------------|-----------:|:--|
| Balance at December 31, 2022                                                                  |     |              | 1,700,414 |     | $