Company: NCNA
Filing Date: 2025-05-02
Form Type: F-1/A
Source: 0001193125-25-110310
Chunk: 43

Company: NuCana plc
Filing Date: 2025-05-02
Form: F-1/A
Chunk 43
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 a transfer in any usual or common form or any form acceptable to the board of directors and permitted by the Companies Act 2006 and any other relevant legislation, except that the deferred shares may only be transferred with the prior written consent of the directors. The board of directors may decline to register a transfer of a share that is:

| • |     | not fully paid or on which we have a lien; |

| • |     | (except where uncertificated shares are transferred without a written instrument) not lodged duly stamped (if it  
 is required to be stamped) at our registered office or at such other place as the board of directors may appoint; |

| • |     | (except where a certificate has not been issued) not accompanied by the certificate of the share to which it                  
 relates or such other evidence reasonably required by the directors to show the right of the transferor to make the transfer; |

| • |     | in respect of more than one class of share; or |

| • |     | in the case of a transfer to joint holders of a share, the number of joint holders to whom the share is to be 
 transferred exceeds four.                                                                                     |

Capital variations.We may, by ordinary resolution, consolidate and divide all or any of our share capital into shares of a larger nominal amount than our existing shares or sub-divideour shares, or any of them, into 24

shares of a smaller nominal amount than our existing shares. Subject to the provisions of the Companies Act 2006 and any other applicable legislation, we may by special resolution reduce our
share capital, any capital redemption reserve fund or any share premium account and may redeem or purchase any of our own shares.

Pre-emptionrights. There are no rights of pre-emption under our articles of association in respect of transfers of issued ordinary shares. In certain circumstances,
our shareholders may have statutory pre-emption rights under the Companies Act 2006 in respect of the allotment of new shares in the company. These statutory pre-emption
rights, when applicable, would require us to offer new shares for allotment to existing shareholders on a pro rata basis before allotting them to other persons. In such circumstances, the procedure for the exercise of such statutory pre-emption rights would be set out in the documentation by which such ordinary shares would be offered to our shareholders. These statutory pre-emption rights may be
disapplied by a special resolution passed by shareholders in a general meeting in accordance with the provisions of the Companies Act