Company: TAK
Filing Date: 2025-06-25
Form Type: F-3ASR
Source: 0001395064-25-000097
Chunk: 29

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-25
Form: F-3ASR
Chunk 29
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 the senior debt securities;

(ii) to add to covenants of the issuer (or, if applicable, the Guarantor) or to surrender any right or power in the applicable indenture conferred upon the issuer (or, if applicable, the Guarantor) for the benefit of the holders of the senior debt securities;

(iii) to evidence and provide for the acceptance of appointment under the applicable indenture by a successor trustee;

(iv) to cure any ambiguity, to correct or supplement any provision in the applicable indenture which may be defective or inconsistent with any other provision in the applicable indenture, or to make any other provisions with respect to matters or questions arising under the applicable indenture, provided that such action shall not adversely affect the interests of the holders of the senior debt securities in any material respect;

(v) to make any other change that does not adversely affect the interests of the holders of the senior debt securities in any material respect; or

(vi) to comply with requirements of the SEC in order to effect or maintain the qualification hereof under the Trust Indenture Act of 1939, as amended (the “Trust Indenture Act”).

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#### The Trustee
Unless otherwise specified in connection with a particular offering of senior debt securities, The Bank of New York Mellon will serve as the trustee.

Any trustee appointed pursuant to the Indentures will have and will be subject to all of the duties and responsibilities under the relevant indenture and those with respect to an indenture trustee under the Trust Indenture Act.

The Indentures provide that during the existence of an event of default with respect to the senior debt securities, the trustee will exercise the rights and powers vested in it by the applicable indenture, and use the same degree of care and skill in the exercise thereof as a prudent person would exercise or use under the circumstances in the conduct of his or her own affairs. In the absence of an event of default with respect to the senior debt securities, the trustee need only perform the duties specifically set forth in the applicable indenture or in the Trust Indenture Act.

The Indentures and the Trust Indenture Act contain limitations on the rights of the trustee under the Indentures, should it be or become a creditor of the issuer (or, if applicable, the Guarantor), to obtain payment of claims. The trustee is not precluded from engaging in other transactions, provided that if it has or acquires any conflicting interest, as defined in Section