Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 11

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 11
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ramed due 18 months from the date of issuance in the principal amount of $101,875,000. |

| • |     | “Penny Warrants” means the warrants to purchase up to an aggregate of 13,000,000 shares of our                    
 Common Stock, each with an exercise price of $0.01 per share, issued to Oramed pursuant to the Scilex-Oramed SPA. |

| • |     | “Private Warrants” means, on a pre-Reverse Stock Split                                                                                                                                                                              
 basis, the 6,840,000 warrants sold in a private placement to Vickers Venture Fund VI Pte Ltd and Vickers Venture Fund VI (Plan) Pte Ltd consummated on January 11, 2021 (of which 2,736,000 were forfeited pursuant to that certain 
 Sponsor Support Agreement, dated March 17, 2022, by and among the Sponsors, Pei Wei Woo, Suneel Kaji,                                                                                                                               |

6

| Steve Myint and Scilex, Inc. (f/k/a Scilex Holding Company) and 3,104,000 were transferred to Sorrento pursuant to that certain Warrant Transfer Agreement, dated as of October 17, 2022, 
 by and among Sorrento, the Sponsors, Vickers and Maxim Group LLC, in each case in connection with the Scilex Business Combination).                                                       |

| • |     | “Public Warrants” means the redeemable warrants that were included in the Units that,                                                                                                           
 following the Scilex Business Combination and the Reverse Stock Split, entitle the holder of each whole warrant to purchase (1/35th) of a share of Common Stock at a price of $402.50 per whole 
 share.                                                                                                                                                                                          |

| • |     | “Scilex Business Combination” means the merger contemplated by the Merger Agreement. |

| • |     | “SCLX JV” means SCLX Stock Acquisition JV LLC, our indirect wholly owned subsidiary. |

| • |     | “SEC” means the U.S. Securities and Exchange Commission. |

| • |     | “Securities Act” means the Securities Act of 1933, as amended. |

| • |     | “Series A Certificate of Designations” means the Certificate of Designations of the Company,                                                                                                           
 designating the series of preferred stock, par value $0.0001 per share, of