Company: BCDRF
Filing Date: 2025-11-06
Form Type: 8-A12B
Source: 0000950103-25-014410
Chunk: 0

Company: Banco Santander, S.A.
Filing Date: 2025-11-06
Form: 8-A12B
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 REQUIRED IN REGISTRATION STATEMENT</div>

The Registrant has filed with the Securities and
Exchange Commission (the “Commission”) pursuant to Rule 424(b) under the Securities Act of 1933, a prospectus supplement dated
October 30, 2025, relating to the Registrant’s Senior Non Preferred Floating Rate Notes due 2030, 4.551% Senior Non Preferred Fixed
Rate Notes due 2030 and 5.127% Senior Non Preferred Fixed Rate Notes due 2035 (the “Prospectus Supplement”), to a base prospectus
dated May 16, 2023 (the “Prospectus”) contained in the registration statement of the Registrant on Form F-3ASR (File No. 333-271955)
filed with the Commission on May 16, 2023, relating to the securities to be registered hereunder. The Registrant incorporates by reference
the Prospectus Supplement and the Prospectus to the extent set forth below.

Item 1. Description of Registrant’s Securities to be Registered

The information required by this item is incorporated
herein by reference to the information contained in the sections captioned “Description of Debt Securities,” “Description
of Certain Provisions Relating to Debt Securities and Contingent Convertible Capital Securities” and “Taxation” of the
Prospectus, and “Description of the Notes” and “Taxation” of the Prospectus Supplement.

Item 2. Exhibits

| 4.1  | Senior Non Preferred Debt Securities Indenture, dated as of March 14, 2024, among Banco Santander, S.A., as Issuer, and The Bank of New York Mellon, London Branch, as Trustee (incorporated herein by reference from Exhibit 4.1 to the Form 6-K filed with the Commission on March 14, 2024 (Accession No. 0001193125-24-067954)).                                                                                                                                                                                        |
| 4.2  | Third Supplemental Indenture, dated as of November 6, 2025, to the Senior Non Preferred Debt Securities Indenture, dated as of March 14, 2024, among Banco Santander, S.A., as Issuer, The Bank of New York Mellon, London Branch, as Trustee, Calculation Agent and Principal Paying Agent, and The Bank of New York Mellon SA/NV, Luxembourg Branch, as Registrar (incorporated herein by