Company: NCNA
Filing Date: 2025-02-14
Form Type: SCHEDULE 13D/A
Source: 0001104659-25-014195
Chunk: 1

Company: NuCana plc
Filing Date: 2025-02-14
Form: SCHEDULE 13D/A
Chunk 1
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 voting power, and Naegler, a member of the investment committee of SC VI, may be deemed to have shared power to vote these shares. Note to Items 9 and 10: SP SAS, the management company of SC VI, may be deemed to have sole power to dispose of these shares, and Naegler, a member of the investment committee of SC VI, may be deemed to have shared power to dispose of these shares. Note in relation to Items 13: Percentage of class is calculated based on 98,630,000 ordinary shares outstanding as of September 30, 2024, as reported in Exhibit 99.1 in NuCana plc's Form 6-K filed with the SEC on November 25, 2024.

| SCHEDULE 13D |

| Item 1.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     | Security and Issuer                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |
| (a)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | Ordinary Shares, nominal value GBP0.04 per share                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| (b)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | NuCana plc                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 |
| (c)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | 3 Lochside Way, Edinburgh,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
 UNITED KINGDOM                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
 , EH12 9DT.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |
| Item 1 Comment:Introductory Statement: This Amendment No. 6 ("Amendment No. 6"), being filed by Sofinnova Capital VI FCPR ("SC VI"), Sofinnova Partners SAS, a French corporation ("SP SAS"), Antoine Papiernik ("Papiernik"), Henrijette Richter ("Richter"), Maina Bhaman ("Bhaman"), Graziano Seghezzi ("Seghezzi"), Anta Gkelou ("Gkelou") and Karl Naegler ("Naegler"), the investment committee of SC VI (collectively, the "Listed Persons" and together with SC VI and SP SAS, the "Reporting Persons"), amends and supplements the Schedule 13D filed with the Securities and Exchange Commission (the "SEC") on February 21, 2018, as amended by Amendment No. 1 to Schedule 13D filed with the SEC on February 14, 2019, as further amended