Company: APM
Filing Date: 2025-10-06
Form Type: S-4
Source: 0001213900-25-096656
Chunk: 7

Company: Aptorum Group Ltd
Filing Date: 2025-10-06
Form: S-4
Chunk 7
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 and DiamiR are excited about the opportunities the Merger brings to Aptorum and DiamiR stockholders and thank you for your consideration and continued support. Sincerely,

| Ian Huen                |     | Alidad Mireskandari      |
| Chief Executive Officer |     | Chief Executive Officer  |
| Aptorum Group Limited   |     | DiamiR Biosciences Corp. |

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the Merger, the issuance of Aptorum securities in connection with the Merger or the other transactions described in the accompanying proxy statement/prospectus or passed upon the adequacy or accuracy of the accompanying proxy statement/prospectus. Any representation to the contrary is a criminal offense. The accompanying proxy statement/prospectus is dated , 2025, and is first being mailed to Aptorum stockholders on or about , 2025.

APTORUM GROUP LIMITED
SPECIAL MEETING OF SHAREHOLDERS
TO BE HELD ON [ ] 2025
NOTICE OF SPECIAL MEETING OF STOCKHOLDERS To the shareholders of Aptorum: NOTICE IS HEREBY GIVENthat an in -personspecial meeting of shareholders of Aptorum Group Limited (the “Special Meeting”), will be held on [ ], 2025, at [9:30 a.m. Eastern Time], unless postponed or adjourned to a later date. The Special Meeting will be held at 17/F., Guangdong Investment Tower,148 Connaught Road Central, Hong Kong. You are cordially invited to attend the Special Meeting to be held for the following purposes: 1.Approve, by an ordinary resolution a share consolidation of the Company’s Class A Ordinary Shares and Class B Ordinary Shares, par value US$0.00001 per share, each in the authorized share capital of the Company (including issued and unissued share capital) at a ratio of [2 -1] or [3 -1] or [4 -1] or [5 -1] or [6 -1] or [7 -1] or [8 -1] or [9 -1] or [10 -1], with the exact ratio to be selected at the sole discretion of the Company’s Board by the day immediately prior to the effective date of the Domestication (the “Share Consolidation Proposal,” “Reverse Stock Proposal” or “Proposal No. 1”); 2.Approve, by special resolution, Aptorum be de -register