Company: GLPG
Filing Date: 2025-03-28
Form Type: 6-K
Source: 0001193125-25-067161
Chunk: 0

Company: GALAPAGOS NV
Filing Date: 2025-03-28
Form: 6-K
Chunk 0
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### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN PRIVATE ISSUER

PURSUANT TO RULE 13a-16OR 15d-16

UNDER THE SECURITIES EXCHANGE ACT OF 1934

For the month of March 2025.

Commission File Number: 001-37384

### GALAPAGOS NV
(Translation of registrant’s name into English)

Generaal De Wittelaan L11 A3

2800 Mechelen, Belgium

(Address of principal executive office)

Indicate by check mark whether
the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F ☒ Form 40-F ☐

Note: Regulation S-T Rule 101(b)(7) only permits
the submission in paper of a Form 6-K if submitted to furnish a report or other document that the registrant foreign private issuer must furnish and make public under the laws of the jurisdiction in which the
registrant is incorporated, domiciled or legally organized (the registrant’s “home country”), or under the rules of the home country exchange on which the registrant’s securities are traded, as long as the report or other
document is not a press release, is not required to be and has not been distributed to the registrant’s security holders, and, if discussing a material event, has already been the subject of a Form 6-K
submission or other Commission filing on EDGAR.

EXPLANATORY NOTE Enclosed hereto are copies of the following items in connection with Galapagos NV’s (the “Company”) annual report for the financial year 2024 and its Annual Shareholders’ Meeting that will be held on Tuesday, April 29, 2025 at 2:00 p.m. (CET), at the registered office of the Company. The information contained in this Form 6-K,including, Exhibits 99.2, 99.3, 99.4, 99.5, 99.6, 99.7, 99.8, 99.9, 99.10 and 99.11 is hereby incorporated by reference into the Company’s Registration Statements on Form S-8(File Nos. 333-204567, 333-208697, 333-211834, 333-215783, 333-218