Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 54

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 54
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 We have no responsibility for the performance by
DTC or its participants of their respective obligations as described in this prospectus supplement or under the rules and procedures governing their respective operations.

“Beneficial owner” refers to the ownership interest of each actual purchaser of each depositary share.

“Direct participants” refers to securities brokers and dealers, banks, trust companies, clearing corporations and other
organizations who, with the New York Stock Exchange, Inc. and the Financial Industry Regulatory

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Authority, Inc., own DTC. Purchases of depositary shares within the DTC system must be made by or through direct participants who will receive a credit for the depositary shares on DTC’s
records.

“Indirect participants” refers to others, like securities brokers and dealers, banks and trust companies that clear
through or maintain custodial relationships with direct participants, either directly or indirectly, and who also have access to the DTC system.

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CERTAIN U.S. FEDERAL INCOME TAX CONSIDERATIONS

The following is a summary of certain U.S. federal income tax consequences relevant to the purchase, ownership and disposition of the
depositary shares by a U.S. holder or non-U.S. holder (each as defined below). This summary is limited to taxpayers who will hold the depositary shares as “capital assets” for U.S. federal income tax
purposes (generally, property held for investment) and who purchase the depositary shares in the initial offering at the initial offering price.

Beneficial owners of depositary shares will be treated as owners of the underlying Series B Preferred Stock for U.S. federal income tax
purposes.

The following summary is based upon current provisions of the Code, Treasury regulations promulgated thereunder, judicial
opinions, published positions of the Internal Revenue Service (the “IRS”) and other applicable authorities, all of which are subject to change or differing interpretation, possibly with retroactive effect. Any such change or interpretation
could affect the accuracy of the statements and conclusions set forth herein. We have not sought any ruling from the IRS with respect to the statements made and the conclusions reached in the following summary, and there can be no assurance that the
IRS will agree with such statements and conclusions.

State, local and foreign tax consequences are not summarized, nor are estate or gift
tax consequences or tax consequences to special classes of investors including, but not limited to, tax-exempt organizations, insurance companies, banks or other financial institutions, partnerships or other