Company: NCNA
Filing Date: 2025-04-24
Form Type: F-6
Source: 0001193805-25-000556
Chunk: 3

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-6
Chunk 3
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 ADS
Letter Agreement, dated as of July 31, 2018, by and between the Company and the Depositary. Previously filed as Exhibit
(b)(ii) to the Post-Effective Amendment No. 1 to the Registration Statement on Form F-6, Reg. No. 333-220392, filed on March 27, 2024,
and incorporated herein by reference.

| (c) | Every material contract relating to the deposited securities between the Depositary and the issuer of 
 the deposited securities in effect at any time within the last three years. ___ None.                 |

| (d) | Opinion of counsel for the Depositary as to the legality of the securities to be registered. ___ 
 Filed herewith as Exhibit (d).                                                                   |

| (e) | Certificate under Rule 466. ___ None. |

| (f) | Powers of Attorney for certain officers and directors and the authorized representative of the Company. 
 ___ Set forth on the signature pages hereto.                                                            |

<div align='center'>II-1</div>

| Item  4. | UNDERTAKINGS |

| (a) | The Depositary undertakes to make available at the principal office of the Depositary in the United States,                                 
 for inspection by holders of ADSs, any reports and communications received from the issuer of the deposited securities which are both       
 (1) received by the Depositary as the holder of the deposited securities, and (2) made generally available to the holders of the underlying 
 securities by the issuer.                                                                                                                   |

| (b) | If the amount of fees charged is not disclosed in the prospectus, the Depositary undertakes to prepare                                 
 a separate document stating the amount of any fee charged and describing the service for which it is charged and to deliver promptly a 
 copy of such fee schedule without charge to anyone upon request. The Depositary undertakes to notify each registered holder of an ADS  
 thirty (30) days before any change in the fee schedule.                                                                                |

<div align='center'>II-2</div>

Pursuant to the requirements
of the Securities Act of 1933, as amended, Citibank, N.A., acting solely on behalf of the legal entity to be created by the Amended and
Restated Deposit Agreement, by and among NuCana plc, Citibank, N.A., as depositary, and all Holders and Beneficial Owners from time to
time of American Depositary Shares to be