Company: PFSA
Filing Date: 2025-10-29
Form Type: 424B3
Source: 0001213900-25-103174
Chunk: 2

Company: Profusa, Inc.
Filing Date: 2025-10-29
Form: 424B3
Chunk 2
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 any amendment or supplement to this prospectus. The information in this prospectus or any amendment
or supplement to this prospectus is accurate only as of its date, regardless of the time of delivery of this prospectus or any amendment
or supplement to this prospectus, as applicable, or any sale of the securities offered by this prospectus. Our business, financial condition,
results of operations and prospects may have changed since that date.

For Investors Outside the United States: The Selling Stockholders
are offering to sell, and seeking offers to buy, the securities offered by this prospectus only in jurisdictions where offers and sales
are permitted. Neither we nor the Selling Stockholders have done anything that would permit this offering or the possession or distribution
of this prospectus in any jurisdiction where action for that purpose is required, other than in the United States. Persons outside
the United States who come into possession of this prospectus must inform themselves about, and observe any restrictions relating
to, the offering of the securities offered by this prospectus and the distribution of this prospectus outside the United States.

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ABOUT THIS PROSPECTUS</div>

This prospectus is part of a registration statement that we filed with
the SEC. The Selling Stockholders may, from time to time, sell the securities offered by it described in this prospectus through
any means described in the section titled “Plan of Distribution.” We will not receive any proceeds from the sale by the Selling
Stockholders of the securities offered by it described in this prospectus. However, we may receive up to $100,000,000 in aggregate gross
proceeds from Ascent under the Purchase Agreement in connection with sales of our shares of Common Stock to Ascent pursuant to the Purchase
Agreement after the date of this prospectus.

We may also file a prospectus
supplement or post-effective amendment to the registration statement of which this prospectus forms a part that may contain material information
relating to these offerings. The prospectus supplement or post-effective amendment may also add, update or change information contained
in this prospectus with respect to that offering. If there is any inconsistency between the information in this prospectus and the applicable
prospectus supplement or post-effective amendment, you should rely on the prospectus supplement or post-effective amendment, as applicable.
Any statement so modified will be deemed to constitute a part of this prospectus only as so modified, and any statement so superseded
will be deemed not to constitute a