Company: PSTV
Filing Date: 2025-04-18
Form Type: 424B3
Source: 0000950170-25-055884
Chunk: 3

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-18
Form: 424B3
Chunk 3
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 with the Securities and Exchange Commission (the “SEC”) on July 10, 2024, as adjusted by the Board from time to time.

There was no arrangement or understanding between Mr. Guse and any other person with respect to his appointment to the Board. In addition, there have been no transactions involving Mr. Guse that would be required to be disclosed pursuant to Item 404(a) of Regulation S-K.

In connection with his appointment, Mr. Guse is expected to execute the Company’s standard form of indemnification agreement for directors, a copy of which was filed as Exhibit 10.1 to the Company’s Current Report on Form 8-K filed with the SEC on February 6, 2020.

Resignation from Board of Directors

On April 18, 2025, Mr. Greg Petersen resigned as a member of the Board. Mr. Petersen informed the Company that his resignation was not the result of any disagreement with the Company on any matter relating to the Company’s operations, policies or practices.

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SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. Date: April 18, 2025 PLUS THERAPEUTICS, INC.

| By: | /s/ Marc H. Hedrick, M.D.                                  |
|     | Marc H. Hedrick, M.D.President and Chief Executive Officer |

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