Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 343

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 343
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 file annual, quarterly and special reports, proxy statements and other information with the SEC. The SEC maintains an
Internet website at http://www.sec.gov that contains reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC, including Scilex. We maintain an Internet website at
www.scilexholding.com. The information contained on our website or that can be accessed through our website does not constitute a part of this report. We make available, free of charge through our Internet website, our Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and amendments to those reports filed or furnished pursuant to
Section 13(a) or 15(d) of the Exchange Act, as soon as reasonably practicable after we electronically file or furnish this information to the SEC.

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MANAGEMENT The following sets forth certain information, as of the date of this prospectus, concerning the persons who are serving as our directors and executive officers. Executive Officers and Directors The following table sets forth the name, age and position of each of our directors and executive officers, as of December 5, 2025.

| Name                              |     | Age |    |     | Position(s)                                                                                     |
| Executive Officers:               |     |     |    |     |                                                                                                 |
| Henry Ji, Ph.D.(4)                |     |     | 61 |     | Chief Executive Officer, President, Chairperson and Director                                    |
| Stephen Ma                        |     |     | 53 |     | Chief Financial Officer, Chief Operating Officer, Senior Vice President, Secretary and Director |
| Non-employee Directors:           |     |     |    |     |                                                                                                 |
| Jay Chun, M.D., Ph.D.(1)(2)(3)(4) |     |     | 61 |     | Director                                                                                        |
| Dorman Followwill(1)(2)(3)        |     |     | 62 |     | Director                                                                                        |
| Yue Alexander Wu, Ph.D.(1)(2)(3)  |     |     | 62 |     | Director                                                                                        |

| (1) | Member of the Audit Committee. |

| (2) | Member of the Compensation Committee. |

| (3) | Member of the Nominating and Corporate Governance Committee. |

| (4) | Member of the Commercialization and Transaction Committee. |

Executive Officers Henry Ji, Ph.D. Dr. Ji was appointed as