Company: SCLXW
Filing Date: 2025-10-28
Form Type: PRE 14A
Source: 0001193125-25-253884
Chunk: 1

Company: Scilex Holding Co
Filing Date: 2025-10-28
Form: PRE 14A
Chunk 1
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 the Special Meeting, if necessary, to solicit additional proxies if there are not            
 sufficient votes at the time of the Special Meeting to approve the Option Repricing Proposal (the “Adjournment Proposal”). |

In order to provide expanded access to our stockholders, our board of directors (our “Board”) has determined to hold a live audio webcast in lieu of an in-personmeeting. You will be able to vote and submit your questions during the meeting at www.virtualshareholdermeeting.com/SCLX2025SM2. The virtual-only approach also lowers costs and aligns with our broader sustainability goals. Although no physical in-personmeeting will be held, we designed the format of the Special Meeting to ensure that our stockholders of record who attend the Special Meeting will be afforded similar rights and opportunities to participate as they would at an in-personmeeting. As always, we encourage you to vote your shares prior to the Special Meeting either by Internet or by proxy card to help make this meeting format as efficient as possible. Our Board has fixed the close of business on November 3, 2025 as the record date for the Special Meeting. Only stockholders of record on November 3, 2025 are entitled to notice of and to vote at the Special Meeting. Further information regarding voting rights and the matters to be voted upon is presented in the Proxy Statement. We intend to mail the Proxy Statement and the accompanying proxy card on or about November 10, 2025 to all stockholders of record entitled to vote at the Special Meeting. YOUR VOTE IS IMPORTANT. Whether or not you plan to attend the Special Meeting, we urge you to submit your vote via the Internet or mail as soon as possible to ensure that your shares are represented. For additional instructions on voting by the Internet, please refer to your proxy card. Returning the proxy does not deprive you of your right to attend the Special Meeting and to vote your shares at the Special Meeting. Please note, however, that if your shares are held of record by a broker, bank or other nominee and you wish to vote at the Special Meeting, you must obtain a proxy issued in your name from that record holder. We appreciate your continued support of Scilex. By order of the Board of Directors, /s/ Henry Ji Henry Ji, Ph.D. Chief Executive Officer, President and Chairperson Palo Alto, CA , 2025

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| PROCEDURAL MATTERS                                                               |     |      |