Company: BOLT
Filing Date: 2025-03-24
Form Type: S-8
Source: 0000950170-25-043900
Chunk: 2

Company: Bolt Biotherapeutics, Inc.
Filing Date: 2025-03-24
Form: S-8
Chunk 2
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5.1).                     |     |                           |     |             |     |         |     |             |
| 24.1*   |     | Power of Attorney (see signature page hereto).                       |     |                           |     |             |     |         |     |             |
| 99.1    |     | 2021 Equity Incentive Plan.                                          |     | S-1/A                     |     | 333-252136  |     |    10.4 |     | 2/1/2021    |
| 99.2    |     | 2021 Employee Stock Purchase Plan.                                   |     | S-1/A                     |     | 333-252136  |     |    10.7 |     | 2/1/2021    |
| 107*    |     | Filing Fee Table.                                                    |     |                           |     |             |     |         |     |             |

| * | Filed herewith |

<div align='center'>SIGNATURES</div>

Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Redwood City, State of California, on March 24, 2025.

| BOLT BIOTHERAPEUTICS, INC. |     |                                                                |
| By:                        |     | /s/ William P. Quinn                                           |
|                            |     | William P. Quinn                                               |
|                            |     | President, Chief Executive Officer and Chief Financial Officer |

### POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints William P. Quinn and Sarah Nemec, and each of them, as his or her true and lawful attorneys-in-fact and agents, each with the full power of substitution, for him or her and in their name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to