Company: TEM
Filing Date: 2025-08-27
Form Type: 424B7
Source: 0001193125-25-189854
Chunk: 13

Company: Tempus AI, Inc.
Filing Date: 2025-08-27
Form: 424B7
Chunk 13
---
                           | 1,192,791 |     |   |   * |   |     |         | — |     |   | — |     |                      | 1,192,791 |     |                           |         — |     |         |   — |   |     |   | — |     | — |

| * | Represents beneficial ownership of less than 1%. |

S-9

| (1) | Assumes that the selling stockholders dispose of all the shares of Class A common stock being registered                                                                                                                                     
 hereunder and do not acquire beneficial ownership of any additional shares of Class A common stock. The registration of these shares of Class A common stock does not necessarily mean that the selling stockholders will sell all or any of 
 such shares of Class A common stock.                                                                                                                                                                                                         |

| (2) | Shares beneficially owned directly or indirectly before the offering include (i) 2,996,830 shares of Class A                                                                                                                                    
 common stock, 75,242 of which are being registered for resale hereby, and (ii) 65,910 shares of Class A common stock that the holder has the right to acquire within 60 days upon conversion or exercise of options and convertible securities. |

| (3) | The aggregate number of shares being registered for resale by this prospectus supplement consists of (i)                                                                                                                                                 
 1,124,714 shares of Class A common stock issued to certain of the selling stockholders pursuant to or in connection with the Merger Agreement, including for services rendered in connection therewith, which includes 85,966 shares of Class A common   
 stock that may be released to certain selling stockholders in connection with the release of a holdback pursuant to the terms of the Merger Agreement, (ii) 17,915 shares of Class A common stock issued to certain of the selling stockholders pursuant 
 to the License Agreement, and (iii) 125,404 shares of Class A common stock issued to certain of the selling stockholders pursuant to the Release Agreement.                                                                                              |

| (4) | Represents selling stockholders who collectively own less than 1% of our Class A common stock outstanding as of 
 the date of this prospectus supplement.                                                                         |

S-10

PLAN OF DISTRIBUTION The shares of Class A common stock owned by the selling stockholders covered by this prospectus supplement and the accompanying prospectus may be offered, sold, transferred or otherwise disposed of from time to time by such selling stockholders. The selling stockholders will act independently of