Company: RNLXY
Filing Date: 2025-12-03
Form Type: F-6 POS
Source: 0001193805-25-001709
Chunk: 3

Company: Renalytix plc
Filing Date: 2025-12-03
Form: F-6 POS
Chunk 3
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 and communications received from the issuer of the deposited securities which are both       
 (1) received by the Depositary as the holder of the deposited securities, and (2) made generally available to the holders of the underlying 
 securities by the issuer.                                                                                                                   |

| (b) | If the amount of fees charged is not disclosed in the prospectus, the Depositary undertakes to prepare                                 
 a separate document stating the amount of any fee charged and describing the service for which it is charged and to deliver promptly a 
 copy of such fee schedule without charge to anyone upon request. The Depositary undertakes to notify each registered holder of an ADS  
 thirty (30) days before any change in the fee schedule.                                                                                |

<div align='center'>II-2</div>

Pursuant to the requirements
of the Securities Act of 1933, as amended, Citibank, N.A., acting solely on behalf of the legal entity created by the Deposit Agreement,
as amended, by and among Renalytix plc, Citibank, N.A., as depositary, and all Holders and Beneficial Owners from time to time of American
Depositary Shares to be issued thereunder, certifies that it has reasonable grounds to believe that all the requirements for filing on
Form F-6 are met and has duly caused this Post-Effective Amendment No. 2 to Registration Statement on Form F-6 to be signed on its behalf
by the undersigned, thereunto duly authorized, in the City of New York, State of New York, on the 3rd day of December,
2025.

| Legal entity created by the Deposit Agreement, as amended, under which the American Depositary Shares registered hereunder are to be issued, each American Depositary Share representing the right to receive fifty (50) ordinary shares of Renalytix plc. |                           |
| CITIBANK, N.A., solely in its capacity as Depositary                                                                                                                                                                                                       |                           |
| By:                                                                                                                                                                                                                                                        | /s/ Joseph Connor         |
|                                                                                                                                                                                                                                                            | Name: Joseph Connor       |
|                                                                                                                                                                                                                                                            | Title:   Attorney-in-Fact |

<div align='center'>II-3</div>

Pursuant to the requirements
of the Securities Act of 1933, as amended, Renalytix plc certifies that it has reasonable grounds to believe that all the requirements
for filing on Form F-6 are met and has duly caused this Post-Effective Amendment No. 2 to