Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 19

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 19
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 for the period after such date.

A “business day” means a day, other than a Saturday or Sunday, that is neither a legal holiday nor a day on which commercial banking institutions are authorized or required by law, regulation or executive order to be closed in The City of New York, London or Tokyo.

#### Guarantee
The Notes will be subject to the Guarantee, as described under the caption “Description of Senior Debt Securities and Guarantee—TPC Guarantee of Securities Issued by TUSFI” in the accompanying prospectus.

#### Additional Amounts

#### Issuer
All payments of principal and interest by the Issuer in respect of the Notes shall be made without withholding or deduction for or on account of any present or future taxes, duties, assessments or governmental charges of whatever nature, unless such withholding or deduction is required by law. If any such withholding or deduction is imposed or levied by or on behalf of the United States, or any political subdivision thereof or any authority therein having power to tax, with respect to payments of principal and interest by the Issuer in respect of the Notes, the Issuer shall pay to the holder of each Note who is a United States Alien, subject to certain exceptions, such additional amounts as will result in the receipt by that holder of such amounts as would have been received by them had no such withholding or deduction been required. For further information, see “Description of Senior Debt Securities and Guarantee—Taxation and Additional Amounts—TUSFI” in the accompanying prospectus.

#### Guarantor
All payments of principal and interest by the Guarantor in respect of the Notes shall be made without withholding or deduction for or on account of any present or future taxes, duties, assessments or governmental charges of whatever nature imposed or levied by or on behalf of Japan, or any authority thereof or therein having power to tax, unless such withholding or deduction is required by law or by the authority. In such event, the Guarantor shall pay, subject to certain exceptions, such additional amounts as will result in the receipt by the holders of such amounts as would have been received by them had no such withholding or deduction been required. For further information, see “Description of Senior Debt Securities and Guarantee—Taxation and Additional Amounts

<div align='center'>S-15</div>

—TPC as an issuer” in the accompanying prospectus. For a discussion of the circumstances under which payments under the Guarantee may be subject to withholding under the laws of Japan, see “Taxation—Japanese Taxation”.

#### Redemption