Company: NCNA
Filing Date: 2025-06-18
Form Type: F-3/A
Source: 0001193125-25-142565
Chunk: 61

Company: NuCana plc
Filing Date: 2025-06-18
Form: F-3/A
Chunk 61
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 the terms of the deposit agreement. You may have to pay fees and expenses incurred in converting foreign currency, such as fees and expenses incurred in complying with currency exchange controls and other governmental requirements. If the conversion of foreign currency is not practical or lawful, or if any required approvals are denied or not obtainable at a reasonable cost or within a reasonable period, the depositary may take any of the following actions in its discretion:

| • |     | Convert the foreign currency to the extent practical and lawful and distribute the U.S. dollars to the ADS 
 holders for whom the conversion and distribution is lawful and practical.                                  |

| • |     | Distribute the foreign currency to ADS holders for whom the distribution is lawful and practical. |

| • |     | Hold the foreign currency (without liability for interest) for the applicable ADS holders. |

Governing Law/Waiver of Jury Trial The deposit agreement and the ADRs will be interpreted in accordance with the laws of the State of New York. The rights of holders of ordinary shares (including ordinary shares represented by ADSs) are governed by the laws of England and Wales. AS A PARTY TO THE DEPOSIT AGREEMENT, YOU IRREVOCABLY WAIVE, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, YOUR RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF THE DEPOSIT AGREEMENT AND/OR THE ADRs AGAINST US OR THE DEPOSITARY. 50

EXPENSES The following is an estimate of the expenses (all of which are to be paid by us) that we may incur in connection with the securities being registered hereby.

| SEC registration fee         |     | $ | — |    |
| FINRA filing fee             |     |   |   | -1 |
| Legal fees and expenses      |     |   |   | -1 |
| Accounting fees and expenses |     |   |   | -1 |
| Printing expenses            |     |   |   | -1 |
| Miscellaneous expenses       |     |   |   | -1 |
| Total                        |     | $ |   | -1 |

| (1) | These fees are calculated based on the securities offered and the number of issuances and accordingly cannot be 
 estimated at this time.                                                                                         |

51

LEGAL MATTERS

Unless the applicable prospectus supplement indicates otherwise, the validity of the debt securities, warrants and units governed by U.S. law
and certain other matters of