Company: RVRC
Filing Date: 2025-10-03
Form Type: S-1/A
Source: 0001213900-25-096094
Chunk: 10

Company: Revium Rx.
Filing Date: 2025-10-03
Form: S-1/A
Chunk 10
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iotics, making it harder to treat. It can cause a range of infections—from minor skin issues to serious bloodstream, lung,
or surgical site infections. It is commonly acquired in hospitals or community settings.

“MICs (Minimum Inhibitory Concentrations)”
are the lowest concentration of an antimicrobial agent that inhibits visible growth of a microorganism, used to assess bacterial susceptibility.

<div align='center'>iii</div>

“MRSA (Methicillin-Resistant Staphylococcus
aureus)” represents a type of bacteria resistant to many antibiotics, including methicillin, commonly associated with healthcare-
and community-acquired infections.

“Nano-Liposomal Particles (NLP)-based medicines”
are specialized nano-scale lipid vesicles engineered to encapsulate therapeutic agents, enhancing their stability, bioavailability, and
targeted delivery to specific tissues or cells.

“Nano-medicines” refer to pharmaceutical
formulations designed at the nanoscale (typically 1 to 100 nanometers) intended to improve drug delivery, increase therapeutic effectiveness,
and reduce adverse effects.

“Neutropenic Lung Infection is lung infection
occurring in individuals with neutropenia (abnormally low levels of neutrophils), commonly seen in immunocompromised patients such as
those undergoing chemotherapy.

“PEGylated nano-liposomes” are nano-liposomes
modified with polyethylene glycol (PEG), a polymer used to improve circulation time in the bloodstream, reduce immunogenicity, and enhance
drug accumulation in target tissues.

“Phagocytic Cells” are Immune cells
(such as macrophages and neutrophils) that engulf and digest pathogens and cellular debris.

“Pharmacokinetics” is the study of
how a drug is absorbed, distributed, metabolized, and eliminated by the body over time.

“Pharmacokinetic Profile” is a characterization
of the drug’s behavior in the body over time, typically including data on absorption, peak concentration, half-life, metabolism,
and excretion.

“PEGylated Liposomal Delivery” A drug
delivery system in which the active compound is encapsulated in liposomes (spherical lipid-based carriers) that are coated with polyethylene
glycol (PEG). PEGylation increases the circulation time of the liposomes in the bloodstream by reducing immune system recognition and
clearance, thereby enhancing drug stability, bioavailability, and targeted delivery to diseased tissues such as tumors or infection sites.

“Retic