Company: JPC
Filing Date: 2025-06-09
Form Type: CORRESP
Source: 0001999371-25-007492
Chunk: 0

Company: Nuveen Preferred & Income Opportunities Fund
Filing Date: 2025-06-09
Form: CORRESP
Chunk 0
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| Chicago                
 New York               
 Washington, DC         
 London                 
 San Francisco          
 Los Angeles            
 Singapore              
 Dallas                 
 Miami                  
 vedderprice.com        
 Deborah Bielicke Eades 
 Shareholder            
 +1 312 609 7661        
 deades@vedderprice.com |

June 9, 2025

VIA EDGAR

U.S. Securities and Exchange Commission
Division of Investment
Management
100 F Street NE
Washington, DC 20549

| Attn: | Ms. Lisa Larkin    |
|       | Mr. Brian Szilagyi |

| Re: | Nuveen Preferred & Income Opportunities 
 Fund                                    |
|     | Registration Statement on Form N-14     |
|     | File No. 333-286736                     |

Dear Ms. Larkin and Mr. Szilagyi:

On behalf of Nuveen Preferred & Income Opportunities
Fund (the “Registrant” or the “Acquiring Fund”), we are responding to the staff’s comments provided telephonically
on May 9, 2025 from Mr. Szilagyi and May 22, 2025 from Ms. Larkin, regarding the Registrant’s Registration Statement on Form N-14
filed on April 24, 2025 (the “Registration Statement”).

For convenience, each comment is restated below,
with the response immediately following. To the extent responses herein reflect revised or additional disclosure, such disclosure will
be reflected in Pre-Effective Amendment No. 1 to the Registration Statement, which is being filed concurrently herewith. All capitalized
terms not defined herein have the meaning assigned to them in the Registration Statement; any page references herein refer to the Joint
Proxy Statement/Prospectus and Statement of Additional Information included in the Registration Statement.

<div align='center'>Accounting Comments</div>

| 1. | Comment: Explain in correspondence and disclose in the Joint Proxy/Prospectus if applicable,                                                     
 if the Merger will be accounted for as an asset acquisition under ASC 805-50. If it is, please disclose if assets acquired are recorded          
 at fair value of consideration transferred or at fair value of assets acquired and how such value will be allocated to acquired assets.          
 Please cite applicable provisions of U.S. GAAP. Please incorporate into the analysis the impact of the Funds’ traded market prices               
 and discounts and premiums to NAV. Also, please explain if any day one unrealized gains and losses will result from the acquisition