Company: TEM
Filing Date: 2025-03-07
Form Type: 424B3
Source: 0001193125-25-049935
Chunk: 24

Company: Tempus AI, Inc.
Filing Date: 2025-03-07
Form: 424B3
Chunk 24
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 over the next four years, subject to Mr. Fukushima’s continuous service to us through each vesting date. In May 2024, prior to our IPO, our board of directors granted Mr. Polovin an RSU award for 20,000 shares of our Class A common stock. One-thirdof the shares subject to this RSU award will vest on March 15, 2025 and 17

the remaining shares will vest in substantially equal quarterly installments thereafter over the next two years, subject to Mr. Polovin’s continuous service to us through each vesting date. Additionally, in November 2024, the compensation committee of our board of directors granted Mr. Polovin an RSU award for 30,000 shares of our Class A common stock. This RSU award will vest in substantially equal quarterly installments over a four-year period that commenced on January 15, 2025, subject to Mr. Polovin’s continuous service to us through each vesting date. Health and Welfare Benefits; Perquisites All of our named executive officers are eligible to participate in our employee benefit plans, including medical, dental, vision, disability and life insurance plans, in each case on the same basis as all of our other full- time employees. We generally do not provide perquisites or personal benefits to our named executive officers, except in limited circumstances. Outstanding Equity Awards as of December 31, 2024 The following table sets forth certain information about outstanding equity awards granted to our named executive officers that remain outstanding as of December 31, 2024:

|                 |     | Stock Awards(1)      |     |                      |     |                |         |     |                |            |
| Name            |     | Grant Date           |     | Vesting Commencement 
 Date                 |     | Number of      
 Shares or      
 Units of Stock 
 that Have Not  
 Vested (#)     |         |     | Market Value   
 of Shares or   
 Units of Stock 
 that Have Not  
 Vested(2)      |            |
| Eric Lefkofsky  |     | July 14, 2021(3)     |     | February 1, 2021     |     |                | 304,125 |     |                | 10,267,260 |
|                 |     | June 13, 2024(4)     |     | September 13, 2024   |     |                | 675,000 |