Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 1

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 1
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 Tranche B warrants to purchase shares of Common Stock (the “October 2024 Noteholder Warrants”). Pursuant to the Warrant Exchange Agreements, the Company and the Tranche B Investors, in
reliance on Section 3(a)(9) of the Securities Act, effected a voluntary securities exchange whereby the Tranche B Investors exchanged their October 2024 Noteholder Warrants, which were then exercisable for an aggregate of 107,142 shares of
Common Stock at an exercise price of $36.40 per share, originally issued pursuant to that certain Securities Purchase Agreement, dated October 7, 2024, by and among the Company and the investors named therein, for the Exchange Warrants to
purchase an aggregate of 500,000 shares of Common Stock at an exercise price of $40.00 per share(subject to adjustment as described in this prospectus). The October 2024 Noteholder Warrants were issued pursuant to our Registration Statement on Form S-3 (File No. 333-276245) (the “Original Registration Statement”), which registration statement was subsequently converted to a registration statement on Form
S-1 to continue the registration of the shares of Common Stock issuable by the Company upon exercise of the October 2024 Noteholder Warrants (File No. 333-280882)
(the Original Registration Statement, as so continued, the “Continuation Registration Statement”) due to the Company’s ineligibility to use a registration statement on Form S-3. For more
information regarding the Exchange Warrants, see the section titled “Description of the Exchange Warrants”.

The
September 2025 Warrants were issued on September 30, 2025, pursuant to a Warrant Exercise Agreement (the “Warrant Exercise Agreement”) (a copy of which is filed as an exhibit to the registration statement of which this prospectus
forms a part) that we entered into on such date with certain holders of then existing December 2024 RDO Common Warrants (as defined below) to purchase an aggregate of 179,236 shares of Common Stock that were previously issued on December 13,
2024 (such holders, the “December 2024 RDO Warrant Holders”). Pursuant to the Warrant Exercise Agreement, the December 2024 RDO Warrant Holders exercised in full their respective December 2024 RDO Common Warrants in exchange for, among
other things, the Company’s agreement to issue the September 2025 Warrants with