Company: TVRD
Filing Date: 2025-01-27
Form Type: S-4/A
Source: 0001104659-25-006050
Chunk: 6

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-01-27
Form: S-4/A
Chunk 6
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 the Merger Agreement, that the stockholders of Cara vote “FOR” each of the proposals set forth in this proxy statement/prospectus.

More information about Cara, Tvardi and the proposed transactions is contained in this proxy statement/prospectus. Cara urges you to read this proxy statement/prospectus carefully and in its entirety. In particular, you should carefully consider the matters discussed under “Risk Factors” beginning on page25.

Cara is excited about the opportunities the Merger brings to Cara’s stockholders, and thank you for your consideration and continued support.

<div align='center'>Christopher Posner

President and Chief Executive Officer

Cara Therapeutics, Inc.</div>

Neither the U.S. Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this proxy statement/prospectus. Any representation to the contrary is a criminal offense.

This proxy statement/prospectus is dated , 2025 and is first being mailed to Cara’s stockholders on or about , 2025.

<div align='center'>400 Atlantic Street

Suite 500

Stamford, CT 06901

NOTICE OF SPECIAL MEETING OF STOCKHOLDERS

To Be Held On , 2025</div>

Dear Stockholders of Cara:

The Cara Board is pleased to deliver this proxy statement/prospectus for the proposed Merger between a wholly owned subsidiary of Cara and Tvardi, for the purpose of, among other things, considering the approval of the issuance of Cara common stock pursuant to the Merger Agreement, among Cara, Merger Sub and Tvardi, pursuant to the Merger.

There will not be a physical meeting location. The Cara special meeting will be held exclusively online via live audio-only webcast on , 2025, at Eastern Time, and can be accessed by visitingwww.virtualshareholdermeeting.com/CARA2025SMwhere you will be able to attend the Cara special meeting via live audio-only webcast. You will be able to vote your shares and submit questions during the Cara special meeting webcast. Online check-in will begin at Eastern Time, and Cara encourages you to allow ample time for the online check-in procedures. Please note that you will not be able to attend the Cara special meeting in person. Cara is holding the Cara special meeting to consider the following proposals:

1.Approve the issuance of shares of Cara common stock pursuant to the Merger, which (i) will represent more than 20% of