Company: NCNA
Filing Date: 2025-04-24
Form Type: F-6
Source: 0001193805-25-000556
Chunk: 4

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-6
Chunk 4
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 issued thereunder, certifies that it has reasonable grounds to believe that all the requirements
for filing on Form F-6 are met and has duly caused this Registration Statement on Form F-6 to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of New York, State of New York, on the 24th day of April, 2025.

| Legal entity created by the Amended and                                                                                               
 Restated Deposit Agreement under which the American Depositary Shares registered hereunder are to be issued, each American Depositary 
 Share representing the right to receive twenty-five (25) ordinary shares of NuCana plc.                                               
 CITIBANK, N.A., solely in its capacity                                                                                                
 as Depositary                                                                                                                         |                         |
| By:                                                                                                                                   | /s/ Joseph Connor       |
|                                                                                                                                       | Name: Joseph Connor     |
|                                                                                                                                       | Title: Attorney-in-Fact |

<div align='center'>II-3

SIGNATURES</div>

Pursuant
to the requirements of the Securities Act of 1933, as amended, NuCana plc certifies that
it has reasonable grounds to believe that all the requirements for filing on Form F-6 are
met and has duly caused this Registration Statement on Form F-6 to be signed on its behalf
by the undersigned thereunto duly authorized, in Edinburgh, United Kingdom, on April 24,
2025.

| NUCANA PLC |                                |
| By:        | /s/ Hugh S. Griffith           |
|            | Name: Hugh S. Griffith         |
|            | Title: Chief Executive Officer |

<div align='center'>II-4</div>

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Hugh S. Griffith to act as his/her true and lawful
attorney-in-fact and agent, with full power of substitution, for him/her and in his/her name, place and stead, in any and all such capacities,
to sign any and all amendments, including post-effective amendments, and supplements to this Registration Statement, and to file the same,
with all exhibits thereto and other documents in connection therewith, with the United States Securities and Exchange Commission, granting
unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to
be done in and about the premises, as fully to all intents and purposes as s/he might