Company: PFSA
Filing Date: 2025-04-28
Form Type: S-4/A
Source: 0001213900-25-035718
Chunk: 301

Company: Profusa, Inc.
Filing Date: 2025-04-28
Form: S-4/A
Chunk 301
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 above for each of Lumee Glucose and Lumee Oxygen in each of the United States and the Europe Union. The numbers below are presented in millions.

| Product Line  |     | Region |     |  2026 |     |  2027 |     |  2028 |     |  2029 |     |  2030 |
| Lumee Glucose |     | US     |     | 35.85 |     | 37.53 |     | 39.34 |     | 41.31 |     | 43.49 |
| Lumee Glucose |     | EUR    |     | 38.31 |     | 40.08 |     | 41.99 |     | 44.08 |     | 46.37 |
| Lumee Oxygen  |     | US     |     | 31.94 |     | 32.26 |     | 32.58 |     | 32.91 |     | 33.24 |
| Lumee Oxygen  |     | EUR    |     | 40.70 |     | 41.63 |     | 42.57 |     | 43.73 |     | 44.71 |

Management then applied estimates of Lumee Oxygen and Lumee Glucose penetration rates in each of the market segments. The average estimated penetration rate for Lumee Glucose across all market segments in Europe ranged from .03% in 2026 to an average .88% in 2030. Penetration rates for Lumee Glucose across all market segments in the US ranged from an average of .0001% in 2026 to an average .87% in 2030. The penetration rates estimated for Lumee Oxygen in the European market for PAD and CLI averaged .23% in 2026 to an average 1.73% in 2030. The average penetration rates in the US for both the PAD and CLI markets averaged .25% in 2026 rising to an average of 2% by 2030. The estimated total revenue was then calculated by multiplying the total addressable market by the estimated annual penetration rate in each market segment to derive total customers. Total customers multiplied by the applicable average unit sale price for Lumee Oxygen or Lumee Glucose then provided total revenue. Lumee Oxygen is projected to see accelerated revenue in 2027 on the basis of various factors, including but not limited to intensified collaboration with and product endorsement