Company: JUNS
Filing Date: 2025-11-26
Form Type: S-1
Source: 0001493152-25-025204
Chunk: 146

Company: JUPITER NEUROSCIENCES, INC.
Filing Date: 2025-11-26
Form: S-1
Chunk 146
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ursors like Tru-Niagen), Novos (targeting aging hallmarks with products like NOVOS Core), Timeline’s urolithin
A supplements and Tally Health (providing personalized longevity supplements and biological age testing). Larger competitors, including
Nestle Health Science (with multiple brands and products), Amway (through Nutrilite’s Healthy Aging Solution), and L’Oreal
(via its Longevity Integrative Science initiative), are also expanding into this space, intensifying competition. Nugevia’s differentiation
lies in its pharmaceutical-grade JOTROL™ technology, which supports higher plasma concentrations (approximately 300 ng/ml)
and effective CNS delivery, positioning it as a premium offering.

Brands like NOVOS, Blueprint,
and Perpetua.Life offer formulas that combine resveratrol with other scientifically validated longevity compounds (e.g., NMN, quercetin,
CoQ10, fisetin) for synergistic effects. In addition, advanced delivery systems such as Liposomal and micellar technologies are widely
used by many companies to enhance the absorption of key actives, similar to Nugevia’s approach, purity and clinical validation.
Furthermore, companies such as ProHealth, Renue By Science, and Decode Age, who offer similar longevity supplements and sell their products
online directly to consumers, emphasize ingredient purity, bioavailability, multi-ingredient formulations and evidence-based dosing, which
is appealing to the target health-conscious consumers seeking credible, science-backed longevity solutions.

Manufacturing

Nugevia products will be manufactured
by Aquanova in Germany. The manufacturing process has several steps, which are: (a) ingredient combinations are manufactured as a liquid
solution by Aquanova in Germany, (b) the liquid solutions are shipped to GMP-certified facility in California for encapsulation into softgels
and (c) finished products are sent in bulk to a final packing and fulfillment center, which ships directly to customers. While all steps
except the initial solution preparation can be handled by U.S. suppliers, changing the first step would require a separate agreement with
Aquanova.

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The FDA requires that that
dietary supplement manufacturers comply with Current Good Manufacturing Practices (cGMP) under 21 CFR Part 111, ensuring product safety,
quality, and accurate labeling. Jupiter must verify that its manufacturing partners, including those involved in producing JOTROL™
or sourcing ingredients like CoQ10, meet these standards. Non-compliance,