Company: TEM
Filing Date: 2025-08-08
Form Type: S-3ASR
Source: 0001193125-25-175993
Chunk: 54

Company: Tempus AI, Inc.
Filing Date: 2025-08-08
Form: S-3ASR
Chunk 54
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 results of operations or cash flow could be seriously harmed. This could cause the trading price of our Class A common stock to decline, resulting in a loss of all or part of your investment.
Please also carefully read the section entitled “Special Note Regarding Forward-Looking Statements.”

4

USE OF PROCEEDS

All of the shares of Class A common stock being offered hereby are being sold by selling stockholders. The selling stockholders listed
under the heading “Selling Stockholders” in this prospectus or any applicable prospectus supplement will receive all of the net proceeds from the sales of shares of Class A common stock. We will not receive any proceeds from the sale
of Class A common stock by the selling stockholders.

We, and not the selling stockholders, will pay the costs, expenses and fees in
connection with the registration of the shares of Class A common stock covered by this prospectus and any accompanying prospectus supplement, but the selling stockholders will pay all discounts, commissions or brokers’ fees or fees of
similar securities industry professionals and transfer taxes, if any, attributable to sales of such shares of Class A common stock.

5

SELLING STOCKHOLDERS

Up to 2,439,155 shares of our Class A common stock are being offered by this prospectus, all of which are being offered for resale for
the account of the selling stockholders named herein. The shares of Class A common stock were issued to the selling stockholders in connection with acquisitions as described further below, and we are registering the resale of the shares of
Class A common stock pursuant to the requirements of certain purchase agreements between us and the selling stockholders. We may register additional shares for resale for the account of additional selling stockholders in the future through an
accompanying prospectus supplement.

We are registering the resale of the shares of Class A common stock held by the selling
stockholders to permit the selling stockholders to resell or otherwise dispose of such shares in the manner contemplated under “Plan of Distribution” in this prospectus and any accompanying prospectus supplement. As used in this
prospectus, the term “selling stockholders” includes the selling securityholders listed in the table below, and the pledgees, donees, transferees, assignees, successors, designees, successors-in-interest and others who later come to hold any of the selling stockholder’s interest in such shares other than through a public sale.

The selling stockholders may sell some, all or none of the shares of