Company: NYXH
Filing Date: 2025-11-14
Form Type: 6-K
Source: 0001104659-25-112470
Chunk: 1

Company: Nyxoah SA
Filing Date: 2025-11-14
Form: 6-K
Chunk 1
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 sell, in a registered direct offering by the Company directly to the RDO Investors (the “Registered Direct Offering”),
1,215,964 ordinary shares, no nominal value per share, of the Company (the “Ordinary Shares”) to the RDO Investors, at a price
of $4.6304 per share, for aggregate gross proceeds to the Company of approximately $5.6 million before deducting related offering expenses.

A copy of the legal opinion and consent of NautaDutilh
BV/SRL relating to the validity of the issuance and sale of the Ordinary Shares is attached as Exhibit 5.1 hereto and is incorporated
by reference herein.

The information contained in this Report, including Exhibit 5.1 hereto, is hereby incorporated by reference into the Company’s registration statements on Form S-8 (Registration Numbers333-285960,333-261233and333-269410) and Form F-3 (Registration Numbers333-285982and333-268955) of the Company (including any prospectuses forming a part of such registration statements) and is a part thereof from the date on which this report is filed, to the extent not superseded by documents or reports subsequently filed or furnished.

Exhibits

| 5.1  | Opinion of NautaDutilh BV/SRL                            |
| 23.1 | Consent of NautaDutilh BV/SRL (contained in exhibit 5.1) |

<div align='center'>SIGNATURES</div>

Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

| Date: November 14, 2025 | NYXOAH SA 
 By:       | /s/ John Landry         |
|:------------------------|:----------|:------------------------|
|                         | Name:     | John Landry             |
|                         | Title:    | Chief Financial Officer |