Company: SPRB
Filing Date: 2025-10-16
Form Type: SCHEDULE 13G
Source: 0001104659-25-100138
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Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-10-16
Form: SCHEDULE 13G
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 set forth in this statement is true, complete and correct. |

| Citadel Advisors LLC |

| Signature:   /s/ Seth Levy                       
   Name/Title:  Seth Levy, Authorized Signatory   
   Date:        10/16/2025                        |

| Citadel Advisors Holdings LP |

| Signature:   /s/ Seth Levy                       
   Name/Title:  Seth Levy, Authorized Signatory   
   Date:        10/16/2025                        |

| Citadel GP LLC |

| Signature:   /s/ Seth Levy                       
   Name/Title:  Seth Levy, Authorized Signatory   
   Date:        10/16/2025                        |

| Citadel Securities LLC |

| Signature:   /s/ Seth Levy                       
   Name/Title:  Seth Levy, Authorized Signatory   
   Date:        10/16/2025                        |

| Citadel Securities Group LP |

| Signature:   /s/ Seth Levy                       
   Name/Title:  Seth Levy, Authorized Signatory   
   Date:        10/16/2025                        |

| Citadel Securities GP LLC |

| Signature:   /s/ Seth Levy                       
   Name/Title:  Seth Levy, Authorized Signatory   
   Date:        10/16/2025                        |

| Kenneth Griffin |

| Signature:   /s/ Seth Levy                    
   Name/Title:  Seth Levy, attorney-in-fact*   
   Date:        10/16/2025                     |

Comments accompanying signature:* Seth Levy is signing on behalf of Kenneth Griffin as attorney-in-fact pursuant to a power of attorney previously filed with the Securities and Exchange Commission, and hereby incorporated by reference herein. The power of attorney was filed as an attachment to a filing by Citadel Advisors LLC on Schedule 13G for Allakos Inc. on October 13, 2023.

| Exhibit Information                   |
| Exhibit 99.1 - Joint Filing Agreement |