Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 228

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 228
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-selling our securities, subject to certain exceptions. The October 2024 Placement Agent Warrants will have the same terms as the October 2024 Noteholder Warrants,
except that the October 2024 Placement Agents have agreed not to exercise the October 2024 Placement Agent Warrants for a period of 180 days following the date of issuance.

On April 16, 2025, in connection with the formation of Scilex Bio, Inc. the Company entered into a Consent, Waiver and Amendment re
Tranche B Senior Secured Convertible Note and Related Transaction Documents (collectively, the “Tranche B Consent and Waivers”) with each of the Tranche B Noteholders, pursuant to which certain definitions in the Tranche B Notes were
modified to reflect, among other things, that Scilex Bio will not be deemed a subsidiary of Scilex under the terms of the Tranche B Notes.

The above description of the Tranche B Consent and Waivers is not complete and is qualified in its entirety by reference to the full text of
the Tranche B Consent and Waivers, copies of which are filed as exhibits to the registration statement of which this prospectus forms a part.

Equity Financings and Purchases

Standby Equity Purchase Agreements

On November 17, 2022, we entered into a standby equity purchase agreement (the “Original Purchase
Agreement”) with Yorkville. On February 8, 2023, we entered into an amended and restated standby equity

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purchase agreement with Yorkville (the “A&R Yorkville Purchase Agreement”), amending, restating and superseding the Original Purchase Agreement. Pursuant to the A&R Yorkville
Purchase Agreement, we had the right, but not the obligation, to sell to Yorkville up to $500.0 million of shares of Common Stock at our request during the 36 months following the date on which the initial registration statement filed with
respect to the shares of Common Stock issuable pursuant thereto was declared effective by the SEC, subject to the terms therein. The registration statement filed with the SEC in connection with the Original Purchase Agreement was initially declared
effective by the SEC on December 9, 2022 and we were able to offer and sell shares of our Common Stock under that agreement, subject to the limitations set forth therein. During the year ended December 31, 2024, we sold 96,982 shares of
Common Stock under the A&R Yorkville Purchase Agreement