Company: TEM
Filing Date: 2025-02-25
Form Type: S-1
Source: 0001193125-25-034442
Chunk: 19

Company: Tempus AI, Inc.
Filing Date: 2025-02-25
Form: S-1
Chunk 19
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| • |     | approving (or, as permitted, pre-approving) all audit and all                                            
 permissible non-audit services to be performed by the independent registered public accounting firm; and |

| • |     | reviewing and discussing material risks relating to data privacy, technology and information security, 
 including cybersecurity.                                                                               |

11

Compensation Committee Our compensation committee consists of Peter J. Barris, David R. Epstein and Nadja West. The chair of our compensation committee is Mr. Barris. Our board of directors has determined that each of Messrs. Barris and Epstein and Ms. West is independent under Nasdaq listing standards and a “non-employeedirector” as defined in Rule 16b-3promulgated under the Exchange Act. The principal duties and responsibilities of our compensation committee include, among other things:

| • |     | approving the retention of compensation consultants and outside service providers and advisors; |

| • |     | reviewing and approving, or recommending that our board of directors approve, the compensation, individual and                                                                                                                          
 corporate performance goals and objectives and other terms of employment of our executive officers, including evaluating the performance of our chief executive officer and, with his assistance, that of our other executive officers; |

| • |     | reviewing and recommending to our board of directors the compensation of our directors; |

| • |     | administering our equity and non-equity incentive plans; |

| • |     | reviewing our practices and policies of employee compensation as they relate to risk management and 
 risk-taking incentives;                                                                             |

| • |     | reviewing and evaluating succession plans for the executive officers; |

| • |     | reviewing and approving, or recommending that our board of directors approve, incentive compensation and 
 equity plans;                                                                                            |

| • |     | overseeing our compensation clawback or similar policies; and |

| • |     | reviewing and establishing general policies relating to compensation and benefits of our employees and 
 reviewing our overall compensation philosophy.                                                         |

Nominating and Corporate Governance Committee Our nominating and corporate governance committee consists of Theodore J. Leonsis, Jennifer A. Doudna and Scott Gottlieb. The chair of our nominating and corporate governance committee is Mr. Leonsis. Our board of directors has determined that each member of the nominating and corporate governance committee is independent under the applicable listing standards of the Nasdaq Stock Market. In addition, Mr. Lefkofsky serves as an observer on our nominating and corporate governance committee. The