Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063906
Chunk: 331

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 331
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As” for poster presentation at the 2024 International Alzheimer’s Association Conference (AAIC) on July29, 2024 ( https://www.prnewswire.com/news -releases /diamir -biosciences-announces-poster - presentation -at-2024-alzheimers-association-international-conference-aaic-302176323 .html). On July 29, 2024, on behalf of DiamiR, Dr. Kumar reported the comparative analysis of 24 microRNAs comprising CogniMIR ®panel in 200 plasma samples with DiamiR’s Generation 1 and Generation 2 software algorithms towards distinguishing cognitively unimpaired, MCI and AD cohorts. The plasma samples for this study were provided by Penn Alzheimer’s Disease Research Center, University of Pennsylvania and the analysis was conducted at DiamiR laboratory between 2022 and 2024. This study builds upon results reported by DiamiR at the AAIC 20023 and described below (see Business section, Characterizing Heterogeneous Groups of Patients with MCI, pre -MCI, and Dementia). miRNA classifiers based on generation 2 algorithm differentiated between cognitively unimpaired, MCI and AD cohorts. HEALTHY BRAIN AGING Using plasma samples collected at the New York Blood Center from cognitively unimpaired individuals 26 -35, 36 -45, 46 -55, 56 -65and 66 -75years old, DiamiR has analyzed the levels of CogniMIR ®miRNA panel during healthy aging and found that sex -dependentchanges in miRNA levels can reflect centrally regulated processes., including changes in hormone levels during menopause. Concentrations of certain miRNAs peaked at different ages, 46 -55- year-oldand 56 -65- year-oldgroups, respectively. This study provides an important insight into biology of DiamiR’s brain -enrichedmiRNA biomarkers detectable in blood plasma. (Aging, 2018 10:3017; Aging, 2018, 10:2557) CIRCULATING ORGAN-ENRICHED miRNAs AS BIOMARKERS OF RETT SYNDROME Rett syndrome (RTT) is a rare (1 in every 10,000 -15,000 live -bornfemale births) neurodevelopmental disorder caused by mutations in the MECP2 gene that is characterized by neurological regression,