Company: ORBS
Filing Date: 2025-10-27
Form Type: 424B5
Source: 0001493152-25-019480
Chunk: 0

Company: Eightco Holdings Inc.
Filing Date: 2025-10-27
Form: 424B5
Chunk 0
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Filed Pursuant to Rule 424(b)(5)

Registration No. 333-290181

PROSPECTUS SUPPLEMENT

<div align='center'>Eightco Holdings Inc.

Up to $2,700,000,000 of Common Stock</div>

This prospectus supplement (this “ Prospectus Supplement”) amends and supplements the information in the prospectus, dated September 10, 2025 (the “ Base Prospectus”), filed with the Securities and Exchange Commission as part of our registration on Form S-3 (File No. 333-290181) (the “ Registration Statement”), which included an “at the market offering” prospectus, dated September 10, 2025 (such prospectus the “ ATM Prospectus,” and together with the Base Prospectus, the “ Prior Prospectus”), relating to the offer and sale of shares of our common stock, par value $0.001 per share (the “ Common Stock”) having an aggregate sales price of up to $2,700,000,000 (the “ ATM Shares”) pursuant to the terms of that certain Sales Agreement, dated September 10, 2025, between the Company and R.F. Lafferty & Co., Inc. (the “ Sales Agent” or “ R.F. Lafferty”) (the “ Sales Agreement”). This Prospectus Supplement should be read in conjunction with the Prior Prospectus, and is qualified by reference thereto, except to the extent that the information herein amends or supersedes the information contained in the Prior Prospectus. This Prospectus Supplement is not complete without, and may only be delivered or utilized in connection with, the Prior Prospectus and any future amendments or supplements thereto.

We are filing this Prospectus Supplement to reflect the amendment and restatement, on October 27, 2025, of the Sales Agreement (the “ A&R Sales Agreement”) to, among other things, add Cantor Fitzgerald & Co. (“ Cantor”) as the principal and/or the sole designated Sales Agent. Pursuant to the A&R Sales Agreement, the Company, from time to time, may issue and sell to or through Cantor, acting as principal and/or the sole designated Sales Agent, the ATM Shares. Each reference to “R.F. Lafferty” as the principal and/or the sole designated Sales Agent in the Prior Prospectus is hereby amended to “Cantor Fitzgerald & Co.,” each reference to “Agent” in the Prior Prospectus is hereby amended to refer to “