Company: NCNA
Filing Date: 2025-04-24
Form Type: F-1
Source: 0001193125-25-092131
Chunk: 14

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-1
Chunk 14
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 this feature, we do not expect to receive any cash proceeds from the exercise of the Series B Warrants because it is highly unlikely that a Series B Warrant holder will elect to pay an exercise price in cash to receive one ADS when they could elect the “zero exercise price” option in these circumstances to receive more ADSs than they would receive if they did pay an exercise price. Additionally, the Warrants contain exercise price adjustments and adjustments to increase the number of ADSs issuable upon the exercise of the Warrants which will increase as the price of our ADSs falls further below the initial exercise price of such Warrants. Implications of Being a Foreign Private Issuer We report under the Exchange Act as a non-U.S.company with foreign private issuer status. As long as we qualify as a foreign private issuer under the Exchange Act, we are exempt from certain provisions of the Exchange Act that are applicable to U.S. domestic public companies, including:

| • |     | the sections of the Exchange Act regulating the solicitation of proxies, consents or authorizations in 
 respect of a security registered under the Exchange Act;                                               |

| • |     | the sections of the Exchange Act requiring insiders to file public reports of their share ownership and   
 trading activities, and liability for insiders who profit from trades made in a short period of time; and |

| • |     | the rules under the Exchange Act requiring the filing with the SEC of quarterly reports on Form 10-Q containing unaudited financial and other specified information, or current reports on Form 8-K upon the occurrence of specified significant events. |

Foreign private issuers are also exempt from certain more stringent executive compensation disclosure rules. Thus, if we remain a foreign private issuer, we will continue to be exempt from the more stringent compensation disclosures required of companies that are not a foreign private issuer. As a consequence, we do not know if some investors will find our ADSs less attractive, which may result in a less active trading market for our ADSs or more volatility in the price of our ADSs.

4

THE OFFERING

| ADSs offered by us | Up to 16,049,383 ADSs, each representing twenty-five ordinary shares, based on an assumed combined public offering price of $0.81 per ADS and accompanying Series A Warrant and Series B Warrant, which is the reported sale price of our ADSs on The 
 Nasdaq Capital Market on April 21, 2025.                                                                                                                                                                                                              |

| Pre-Funded Warrants offered by us