Company: EVGN
Filing Date: 2025-03-27
Form Type: 20-F
Source: 0001178913-25-001092
Chunk: 65

Company: Evogene Ltd.
Filing Date: 2025-03-27
Form: 20-F
Item: Item 4
Chunk 65
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Product Development Cycle
 
Lavie Bio estimates that developing an ag-biological product based on microbial sources takes, on average, between six to eight years. The length of the process may vary depending on several factors, such as product type, target market and applicable regulatory or registration regime, type of application, type of natural source serving as active ingredient, as well as number of active ingredients within the final products, which impacts the development activities required to reach a commercially viable product.
 
The development process for microbial-based ag-biologicals is generally divided into four steps, or phases, which include discovery, pre-development, development, pre-commercialization, and ending with registration approval and commercial launch. As this is a relatively young industry, the process is not yet well-established and standardized, and the below outline is established based on our experience and estimations.
 

◾                                   Discovery: The identification of a candidate microbial strain, or microbial                                
     strain teams, having the potential to improve the target trait and the potential to achieve other product requirements such as consistency
     and commercial viability. A collection of selected microbial candidates is typically tested on the crop(s) of choice in greenhouse screens
    or limited field experiments for various efficacy, consistency and commercial viability criteria. Candidates that meet the testing criteria
            are referred to as “Hits”. Typically, based on Lavie Bio’s experience, the duration of the discovery phase is approximately        
                                                                   12-18 months.                                                               
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◾                                      Pre-development: Promising Hits are advanced to pre-development phase,                                   
    in order to further assess and optimize performance criteria such as shelf life stability, efficacy and consistency. Successfully performing
                microbial candidates are referred to as “Advanced Hits”. Typically, based on Lavie Bio’s experience, the duration of            
                                                     this phase is approximately 12-18 months.                                                  
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◾                                    Development: This phase is usually divided into Development Stage 1, resulting                                
                with a “Lead”, and Development Stage 2, resulting with a “Pre-Product”. In this phase, the fermentation and formulation            
    procedures are further optimized to allow for further testing and validation of efficacy and consistency in the field as well as for commercial
        viability at the scale production, addressing cost of goods targets and compatibility with other agricultural inputs. Based on industry