Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119822
Chunk: 403

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 403
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 exchange or otherwise; |

| • |     | in ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers; |

| • |     | in block trades in which the broker-dealer will attempt to sell the shares as agent but may position and resell a 
 portion of the block as principal to facilitate the transaction;                                                  |

| • |     | through purchases by a broker-dealer as principal and resale by the broker-dealer for its account; |

| • |     | in an exchange distribution in accordance with the rules of the applicable exchange; |

| • |     | in privately negotiated transactions; |

| • |     | in short sales; |

| • |     | through the distribution of the Common Stock by any Selling Securityholder to its partners, members or 
 stockholders;                                                                                          |

| • |     | through one or more underwritten offerings on a firm commitment or best efforts basis; |

| • |     | in sales pursuant to Rule 144; |

| • |     | whereby broker-dealers may agree with the Selling Securityholder to sell a specified number of such shares at a 
 stipulated price per share;                                                                                     |

| • |     | in a combination of any such methods of sale; and |

| • |     | in any other method permitted pursuant to applicable law. |

If the Selling Securityholder effects such transactions by selling shares of Common Stock to or through underwriters, broker-dealers or agents, such underwriters, broker-dealers or agents may receive commissions in the form of discounts, concessions or commissions from the Selling Securityholder or commissions from purchasers of the shares of Common Stock for whom they may act as agent or to whom they may sell as principal (which discounts, concessions or commissions as to particular underwriters, broker-dealers or agents may be in excess of those customary in the types of transactions involved). In connection with sales of the shares of Common Stock or otherwise, the Selling Securityholder may enter into hedging transactions with broker-dealers, which may in turn engage in short sales of the shares of Common Stock in the course of hedging in positions they assume. The Selling Securityholder may also sell shares of Common Stock short and deliver shares of Common 258

Stock covered by this prospectus to close out short positions and to return borrowed shares in connection with such short sales. The Selling Securityholder may also loan or pledge shares of
Common Stock to broker-dealers that in turn may sell such shares.

The Selling Securityholder may pledge or grant a