Company: IOBT
Filing Date: 2025-05-23
Form Type: S-3
Source: 0001193125-25-125831
Chunk: 25

Company: IO Biotech, Inc.
Filing Date: 2025-05-23
Form: S-3
Chunk 25
---
 limit the liability of our directors for monetary damages to the fullest extent permitted by the DGCL. Consequently, our directors are not personally liable to us or our stockholders for monetary damages for any breach of fiduciary duties as directors, except liability for:

| • |     | any breach of the director’s duty of loyalty to us or our stockholders; |

| • |     | any act or omission not in good faith or that involves intentional misconduct or a knowing violation of law; |

| • |     | unlawful payments of dividends or unlawful stock repurchases or redemptions as provided in Section 174 of 
 the DGCL; or                                                                                              |

| • |     | any transaction from which the director derived an improper personal benefit. |

Our amended and restated certificate of incorporation provides that we shall indemnify each of our directors and executive officers, and shall have power to indemnify our other officers, employees and agents, to the fullest II-1

extent permitted by the DGCL as the same may be amended. At the 2023 Annual Meeting of Stockholders, the Company’s stockholders approved an amendment to, and the Company subsequently amended, its amended and restated certificate of incorporation to extend the indemnification of officers pursuant to recent amendments to the General Corporation Law of the State of Delaware. Subject to certain limitations and limited exceptions, our amended and restated certificate of incorporation provides for the advancement of expenses to each of our directors and, in the discretion of the board of directors, to certain officers and employees, for the defense of any action for which indemnification is required or permitted. We have entered into indemnification agreements with certain of our directors and our executive officers. These agreements will provide that we will indemnify such directors and officers to the fullest extent permitted by law and our amended and restated certificate of incorporation. We also maintain a general liability insurance policy that covers certain liabilities of our directors and officers arising out of claims based on acts or omissions in their capacities as directors or officers. Item 16. Exhibits.

| Exhibit 
 No.     
 3.1     
 3.2     |     | Description                                                                                                                                                                                                                                     
 Form of Amended and Restated Certificate of Incorporation of IO Biotech, Inc. (filed as Exhibit 3.1 to Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on August 11, 2023 and incorporated herein by reference) 
 Form of Amended and Restated Bylaws (filed as Exhibit 3.1