Company: SPRB
Filing Date: 2025-12-12
Form Type: 424B3
Source: 0001193125-25-317547
Chunk: 10

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-12-12
Form: 424B3
Chunk 10
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SELECTED FINANCIAL DATA REFLECTING REVERSE STOCK SPLIT Reverse Stock Split On July 23, 2025, we completed a one-for-seventy-five (1:75) reverse stock split of our outstanding common stock, effective as of August 4, 2025, or the Reverse Stock Split. Based on such Reverse Stock Split, the total number of outstanding shares of common stock was adjusted from 42,231,285 to approximately 563,042. The par value per share of the common stock remained unchanged at $0.0001. Our audited consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2024, and the unaudited condensed consolidated financial statements included in our Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2025, which are incorporated by reference into this prospectus, are presented without giving effect to the reverse stock split. Except where the context otherwise requires, share numbers in this prospectus supplement reflect the one-for-seventy-five reverse stock split of our common stock. The following selected financial data has been derived from our audited consolidated financial statements included in our Annual Report on Form 10-K filed with the SEC on April 15, 2025, and our unaudited condensed consolidated financial statements included in our Quarterly Report on Form 10-Q filed with the SEC on May 6, 2025, as adjusted to reflect the reverse stock split for all periods presented. Our historical results are not indicative of the results that may be expected in the future and results of interim periods are not indicative of the results for the entire year. AS REPORTED (in thousands, except share and per share amounts)

|                                                                        |     | Year Ended December 31, |       2024 |   |     |   |       2023 |   |
|:-----------------------------------------------------------------------|:----|:------------------------|-----------:|:--|:----|:--|-----------:|:--|
| Net loss                                                               |     | $                       |    (53,036 | ) |     | $ |    (47,919 | ) |
| Net loss per share, basic and diluted                                  |     | $                       |      (1.29 | ) |     | $ |      (1.24 | ) |
| Weighted-average shares of common stock outstanding, basic and diluted |     |                         | 41,264,948 |