Company: SCLXW
Filing Date: 2025-11-24
Form Type: 424B3
Source: 0001193125-25-293882
Chunk: 5

Company: Scilex Holding Co
Filing Date: 2025-11-24
Form: 424B3
Chunk 5
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 Company and the Investor. The form of Warrant Inducement Agreement is filed as Exhibit 10.1, the form of November 2025 Warrant is filed as Exhibit 10.2, and the form of Placement Agent Warrant is filed as Exhibit 10.3, in each case to this Current Report on Form 8-Kand are incorporated herein by reference. The foregoing descriptions of the terms of the forms of the Warrant Inducement Agreement, the November 2025 Warrant and Placement Agent Warrant do not purport to be complete and are qualified in their entirety by reference to such exhibits. 2

No Solicitation This Current Report on Form 8-Kshall not constitute an offer to sell or a solicitation of an offer to buy any securities, nor shall there be any sale of securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or other jurisdiction.

| Item 3.02. | Unregistered Sales of Equity Securities. |

The information contained above in Item 1.01 with respect to the issuance of the November 2025 Warrant and the Placement Agent Warrant pursuant to the Warrant Inducement Agreement and the Engagement Agreement, as applicable, is hereby incorporated by reference into this Item 3.02. The November 2025 Warrant and the Placement Agent Warrants described in Item 1.01 above were offered in a private placement pursuant to an applicable exemption from the registration requirements of the Securities Act and, along with the shares of Common Stock issuable upon the exercise thereof, have not been registered under the Securities Act, and may not be offered or sold in the United States absent registration with the Securities and Exchange Commission or an applicable exemption from such registration requirements. The November 2025 Warrant was offered only to the Investor, an accredited investor.

| Item 9.01. | Financial Statements and Exhibits. |

(d) Exhibits.

| Exhibit 
 Number  
 10.1    
 10.2    |     | Description                                                                                                                    
 Warrant Inducement Agreement, dated as of November 23, 2025, by and between the Company and Armistice Capital Master Fund Ltd. 
 Form of November 2025 Warrant                                                                                                  |
|:--------|:----|:-------------------------------------------------------------------------------------------------------------------------------|
| 10.3    |     | Form of Placement Agent Warrant                                                                                                |
| 104     |     |