Company: RNLXY
Filing Date: 2025-07-29
Form Type: POS AM
Source: 0001213900-25-068777
Chunk: 1

Company: Renalytix plc
Filing Date: 2025-07-29
Form: POS AM
Chunk 1
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-effective amendment filed pursuant
to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier
effective registration statement for the same offering. ☐

If this Form is a registration statement pursuant to General
Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e)
under the Securities Act, check the following box. ☐

If this Form is a post-effective amendment to a registration
statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant
to Rule 413(b) under the Securities Act, check the following box. ☐

Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging
growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer | ☐ | Accelerated filer         | ☐ |
| Non-accelerated filer   | ☒ | Smaller reporting company | ☒ |
|                         |   | Emerging growth company   | ☒ |

If an emerging growth company, indicate by check mark if the
registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
provided pursuant to Section 7(a)(2)(B) of Securities Act. ☐

<div align='center'>DEREGISTRATION OF SECURITIES</div>

This Post-Effective Amendment No. 1 relates
to the following Registration Statement (the “Registration Statement”), filed with the Securities Exchange Commission
(the “SEC”) by Renalytix plc (the “Registrant”):

| ● | Registration Statement No. 333-274733 on Form S-3, originally filed with the SEC on September 28, 2023. |

The Registrant is filing this Post-Effective Amendment
to deregister any and all securities that remain unsold under the Registration Statement as of the date hereof. In accordance with the
undertakings made by the Registrant in the Registration Statement to remove from registration by means of a post-effective amendment any
securities that had been registered for issuance but remain unsold at the termination of the