Company: SHPH
Filing Date: 2025-03-19
Form Type: PRE 14A
Source: 0001493152-25-010886
Chunk: 1

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-03-19
Form: PRE 14A
Chunk 1
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5.                                                                                                               |     | BOARD                 
 VOTING RECOMMENDATION 
 FOR                   
 each director nominee 
 FOR                   |
|:---------------------------------------------------------------------------------------------------------------------------------|:----|:----------------------|
| Proposal                                                                                                                         
 No. 3: To approve (on an advisory basis) the Company’s executive compensation.                                                   |     | FOR                   |
| Proposal                                                                                                                         
 No. 4: To authorize the Board of Directors to amend the Company’s amended and restated certificate of incorporation to           
 effect a reverse stock split of the Company’s issued and outstanding common stock by a ratio in the range of 1-for-3 to 1-for-10 
 (the “Reverse Stock Split”).                                                                                                     |     | FOR                   |
| Proposal                                                                                                                         
 No. 5: To transact any other business as may properly be presented at the Annual Meeting or any adjournment thereof.             |     |                       |

This notice, proxy statement and voting instructions are being mailed to stockholders beginning on or about March [*], 2025.

Your vote is important

Regardless of whether you plan to attend the live meeting, we encourage you to vote as soon as possible in one of the following ways:

| VIA                                    
 THE INTERNET                           |     | BY                                      
 TELEPHONE                               |     | BY                                                        
 MAIL                                                      |     | AT                                         
 THE VIRTUAL MEETING                        |
| Visit                                  
 the web site listed on your proxy card |     | Call                                    
 the telephone number on your proxy card |     | Sign,                                                     
 date, and return your proxy card in the enclosed envelope |     | Attend                                     
 the Annual Meeting online at               
 www.virtualshareholdermeeting.com/SHPH2025 |

Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to Be Held on May 9, 2025. Our Proxy Statement is available on our website at https://shuttlepharma.com/. For further information about the Company, including copies of our audited financial statements for the fiscal year ended December 31, 2024, please see our annual report on Form 10-K filed with the Securities and Exchange Commission, or the SEC, on February 26, 2025, as well as other SEC filings made since that date.

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Table of Contents

| PROXY SUMMARY                                                                                                                                                                                                                                                          |  3 |
| Meeting Information                                                                                                                                                                                                                                                    |  3 |
| Introduction of Director Nominees                                                                                                                                                                                                                                      |  4 |
| Compensation Highlights                                                                                                                                                                                                                                                |