Company: XXII
Filing Date: 2025-07-02
Form Type: 424B3
Source: 0001641172-25-017570
Chunk: 3

Company: 22nd Century Group, Inc.
Filing Date: 2025-07-02
Form: 424B3
Chunk 3
---
 unable to resolve these matters favorably, then our business, operating results and financial condition may be adversely    
 affected.                                                                                                                             |
| ● | Future                                                                                                                                
 sales of our common stock will result in dilution to our common stockholders.                                                         |
| ● | We                                                                                                                                    
 have a significant number of outstanding warrants with anti-dilution price protection and alternative cashless exercise provisions.   |
| ● | We                                                                                                                                    
 do not expect to declare any dividends on our common stock in the foreseeable future.                                                 |

You also should carefully review the risk factors and cautionary statements described in the other documents we file or furnish from time to time with the SEC, including our Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. The forward-looking statements included in this prospectus and any other offering material, or in the documents incorporated by reference into this prospectus and any other offering material, are made only as of the date of the prospectus and any other offering material or the incorporated document.

We do not assume any obligation to update any forward-looking statements. We disclaim any intention or obligation to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise.

| iii |

<div align='center'>22 ndCentury Group, inc.</div>

22nd Century Group, Inc. is a tobacco products company with sales and distribution of our own proprietary new reduced nicotine tobacco products authorized as Modified Risk Tobacco Products by the FDA. Additionally, we provide contract manufacturing services for conventional combustible tobacco products for third-party brands.

Our mission in tobacco is dedicated to mitigating the harms of smoking through our proprietary reduced nicotine content (“RNC”) tobacco plants and our Very Low Nicotine, VLN® combustible cigarette products. In December 2021, we secured the first and only authorization from the FDA to market a combustible cigarette, our brand VLN ® as a Modified Risk Tobacco Product (“MRTP”) using certain reduced nicotine exposure claims. In April 2022, the inaugural launch of our proprietary VLN ® cigarettes commenced through a pilot program in select Circle K stores in and around Chicago, Illinois. Building on the success of the pilot, we initiated a phased rollout strategy in 2023, progressing state by state and region by region to a store footprint spanning more than 5,000 stores in 26 states. Our VLN ® tobacco products are supported by a substantial intellectual property portfolio comprising issued patents and patent applications related to tobacco plants, and in