Company: AZN
Filing Date: 2025-11-10
Form Type: 6-K
Source: 0001654954-25-012757
Chunk: 0

Company: ASTRAZENECA PLC
Filing Date: 2025-11-10
Form: 6-K
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#### FORM 6-K
<div align='center'>SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Report of Foreign Issuer

Pursuant to Rule 13a-16 or 15d-16 of

the Securities Exchange Act of 1934

For the month of November 2025

Commission File Number: 001-11960</div>

#### AstraZeneca PLC
<div align='center'>1 Francis Crick Avenue

Cambridge Biomedical Campus

Cambridge CB2 0AA

United Kingdom

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F X Form 40-F __

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ______

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes __ No X

If “Yes” is marked, indicate below the file number assigned to the Registrant in connection with Rule 12g3-2(b): 82-_____________</div>

#### AstraZeneca PLC
<div align='center'>INDEX TO EXHIBITS</div>

#### 1.

#### Director/PDMR Shareholding
10 November 2025

<div align='center'>**Transaction by Person Discharging Managerial Responsibilities**</div>

AstraZeneca PLC (the Company) announces that, on 7 November 2025, it was notified by Pascal Soriot, Executive Director and Chief Executive Officer, that, on 7 November 2025, Mr Soriot ceased to be beneficially interested in 136,537 ordinary shares of $0.25 each in the Company, following the gift of those shares to family members for nil consideration.

Further details are set out in the attached notification, made in accordance with the requirements of the EU Market Abuse Regulation (as it forms part of UK law pursuant to the European Union (Withdrawal) Act 2018).

| 1  |     Details of the person discharging managerial responsibilities /