Company: PAYX
Filing Date: 2025-04-09
Form Type: 424B2
Source: 0001193125-25-076822
Chunk: 2

Company: PAYCHEX INC
Filing Date: 2025-04-09
Form: 424B2
Chunk 2
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 1,495,800,000 |     |                       | 0.600% |     | $     |  9,000,000 |     |                                  | 99.120% |     | $     | 1,486,800,000 |
| 5.350% Notes due 2032 |     |                          | 99.607% |     | $     | 1,494,105,000 |     |                       | 0.625% |     | $     |  9,375,000 |     |                                  | 98.982% |     | $     | 1,484,730,000 |
| 5.600% Notes due 2035 |     |                          | 99.251% |     | $     | 1,191,012,000 |     |                       | 0.650% |     | $     |  7,800,000 |     |                                  | 98.601% |     | $     | 1,183,212,000 |
| Total                 |     |                          | —       |     | $     | 4,180,917,000 |     |                       | —      |     | $     | 26,175,000 |     |                                  | —       |     | $     | 4,154,742,000 |

| (1) | Plus accrued interest, if any, from April 10, 2025. |

The notes will be ready for delivery in book-entry form, only through the facilities of The Depository Trust Company for the accounts of its participants, which may include Clearstream Banking, société anonyme, and Euroclear Bank S.A./N.V., as operator of the Euroclear System, against payment in New York, New York, on or about April 10, 2025, which will be the second business day following the date of this prospectus supplement (such settlement being referred to as “T+2”). Pursuant to Rule 15c6-1under the Exchange Act, trades in the secondary market generally are required to settle in one business day unless the parties to any such trade expressly agree otherwise. Accordingly, purchasers of the notes who wish to trade the notes prior to the first business day preceding the settlement date will be required, by virtue of the fact that the notes initially will settle in T+2, to specify an alternative settlement cycle at the time of any such trade to prevent failed