Company: TVRD
Filing Date: 2025-02-14
Form Type: S-4/A
Source: 0001104659-25-013053
Chunk: 961

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-02-14
Form: S-4/A
Chunk 961
---
 the Merger, and (iv) Cara net cash at the Effective Time of at least $18.0 million.

<div align='center'>F-133</div>

TABLE OF CONTENTS

#### Annex A

### AGREEMENT AND PLAN OF MERGERAND REORGANIZATION
<div align='center'>among:</div>

#### CARA THERAPEUTICS, INC.
<div align='center'>a Delaware corporation;</div>

#### CT CONVERGENCE MERGER SUB, INC.,
<div align='center'>a Delaware corporation; and</div>

#### TVARDI THERAPEUTICS, INC.
<div align='center'>a Delaware corporation

Dated as of December 17, 2024</div>

TABLE OF CONTENTS

TABLE OF CONTENTS

| ​                                                               | ​ | ​ | Page |   |      |   | ​ |
| Section 1.                                                      
 DESCRIPTION OF TRANSACTION                                      
 ​                                                               | ​ | ​ | ​    | ​ | A-2  | ​ | ​ |
| 1.1                                                             
 The Merger                                                      
 ​                                                               | ​ | ​ | ​    | ​ | A-2  | ​ | ​ |
| 1.2                                                             
 Effects of the Merger                                           
 ​                                                               | ​ | ​ | ​    | ​ | A-2  | ​ | ​ |
| 1.3                                                             
 Closing; Effective Time                                         
 ​                                                               | ​ | ​ | ​    | ​ | A-2  | ​ | ​ |
| 1.4                                                             
 Certificate of Incorporation and Bylaws; Directors and Officers 
 ​                                                               | ​ | ​ | ​    | ​ | A-2  | ​ | ​ |
| 1.5                                                             
 Conversion of Shares                                            
 ​                                                               | ​ | ​ | ​    | ​ | A-3  | ​ | ​ |
| 1.6                                                             
 Calculation of Parent Net Cash                                  
 ​                                                               | ​ | ​ | ​    | ​ | A-4  | ​ | ​ |
| 1.7                                                             
 Closing of the Company’s Transfer Books                         
 ​                                                               | ​ | ​ | ​    | ​ | A-5  | ​ | ​ |
| 1.8                                                             
 Surrender of Certificates                                       
 ​                                                               | ​ | ​ | ​    | ​ | A-5  | ​ | ​ |
| 1.9                                                             
 Appraisal Rights                                                
 ​                                                               | ​ | ​ | ​    | ​