Company: PSTV
Filing Date: 2025-04-11
Form Type: POS AM
Source: 0001193125-25-079109
Chunk: 3

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-11
Form: POS AM
Chunk 3
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 Insiders”); and |

| • |     | up to 3,091,908 shares of common stock issuable upon exercise of Series B common stock warrants (“Series B                                                                          
 Common Stock Warrants”, and together with the Series A Common Stock Warrants, the “Common Warrants” and the Common Warrants together with the Pre-Funded Warrants, the “Warrants”). |

The shares of common stock and Warrants were issued pursuant to the Securities Purchase Agreement, dated May 5, 2024 (the “Securities Purchase Agreement”) (the “Initial Subscription”), among us and certain accredited investors and Company insiders named therein (the “Purchasers,” or “selling stockholders”), which was subsequently amended by the First Amendment to the Securities Purchase Agreement, dated May 8, 2024 (the “First Amendment to the Securities Purchase Agreement”) (the “Additional Subscription”), and further amended by the Second Amendment to the Securities Purchase Agreement, dated February 13, 2025 (the “Second Amendment to the Securities Purchase Agreement,” and together with the Securities Purchase Agreement and First Amendment to the Securities Purchase Agreement, the “Purchase Agreement”). The shares of common stock are registrable for resale pursuant to that certain Registration Rights Agreement, dated May 5, 2024 (the “Registration Rights Agreement”), that we entered into with the Purchasers in connection with the Purchase Agreement. See the section below entitled “Selling Stockholders” for additional information regarding the Purchasers. Our registration of the resale of the shares of common stock covered by this prospectus does not mean that the selling stockholders will offer or sell all or any of the shares of common stock. The selling stockholders may offer, sell or distribute all or a portion of their shares of common stock from time to time directly or indirectly through one or more underwriters, broker-dealers or agents, and in one or more public or private transactions. The shares of common stock may be sold in one or more transactions at fixed prices, at prevailing market prices at the time of the sale, at varying prices determined at the time of sale or at negotiated prices. These sales may be effected in transactions, which may involve crosses or block transactions. See the section below entitled “ Plan of Distribution” for more information. We are not selling any shares of common stock under this prospectus and will not receive any proceeds from the sale of shares of common stock by the selling stockholders or their donees, pledgees, assignees, transferees or other successors-in