Company: AZN
Filing Date: 2025-09-29
Form Type: 6-K
Source: 0001104659-25-094039
Chunk: 25

Company: ASTRAZENECA PLC
Filing Date: 2025-09-29
Form: 6-K
Chunk 25
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 on their statement of entitlement. Alternatively, CSN Participants who wish to lodge a trade with a third party may withdraw from the CSN Facility (as described below) before lodging a trading instruction with their chosen third party broker.

To the extent possible, all mandates, preferences and other instructions in force and duly notified to AstraZeneca immediately prior to the Effective Time relating to AstraZeneca Shares (and to be represented by AstraZeneca DIs following the Effective Time) shall, unless and until revoked or amended, be deemed as from the Effective Time to be valid and effective mandates, preferences and instructions to Computershare UK in relation to the AstraZeneca DIs held through the CSN Facility issued in respect thereof.

#### Withdrawal from the CSN Facility
CSN Participants will be able to withdraw from the CSN Facility by completing the relevant form provided by the CSN Operator and providing details of the CREST account to which the AstraZeneca DIs, or the DTC participant to which the underlying AstraZeneca Shares, should be delivered, in accordance with the rules and practices of the CSN Nominee, CREST and DTC (as applicable). CSN Participants may also request that the underlying AstraZeneca Shares are withdrawn from the CSN Facility and registered in their name directly on the Register, as will be administered in the United States by CTCNA.

Valid instructions received by the CSN Operator are typically completed within 48 hours (excluding any non-working days in any relevant jurisdictions) and CSN Participants should consider these timings, and those of their chosen broker, when instructing trades.

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**Withdrawal from the CSN Facility is subject to a charge, being**

#### £

**50 at the Latest Practicable Date, but a grace period of 30 calendar days from the Effective Time will be provided during which CSN Participants can withdraw from the CSN Facility free of charge.**

#### Other terms of the CSN Facility
The CSN Nominee will hold, as nominee for the CSN Operator, AstraZeneca DIs for CSN Participants on the CSN Terms and Conditions annexed to this document. Under the CSN Terms and Conditions, each CSN Participant is the beneficial owner of those AstraZeneca DIs which represent their underlying AstraZeneca Shares and may give instructions to transfer the AstraZeneca DIs or underlying AstraZeneca Shares. By participating