Company: SPRB
Filing Date: 2025-06-06
Form Type: DEFA14A
Source: 0000950170-25-083045
Chunk: 0

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-06-06
Form: DEFA14A
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<div align='center'>SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the
Securities Exchange Act of 1934
(Amendment No. )</div>

Filed by the Registrant☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:

☐Preliminary Proxy Statement

☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

☐Definitive Proxy Statement

☒Definitive Additional Materials

☐ Soliciting Material Pursuant to §240.14a-12

<div align='center'>Spruce Biosciences, Inc.(Name of Registrant as Specified In Its Charter)

N/A

(Name of Person(s) Filing Proxy Statement if Other Than the Registrant)</div>

Payment of Filing Fee (Check the appropriate box):

☒No fee required.

☐ Fee paid previously with preliminary materials

☐ Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

<div align='center'>SUPPLEMENT TO THE PROXY STATEMENT

FOR THE ANNUAL MEETING OF STOCKHOLDERS

TO BE HELD ON JUNE 9, 2025

EXPLANATORY NOTE</div>

On April 28, 2025, Spruce Biosciences Inc. (the “Company”) filed a definitive proxy statement (the “Proxy Statement”) with the Securities and Exchange Commission relating to its Annual Meeting of Stockholders to be held on Monday, June 9, 2025 at 10:00 a.m., Pacific Time (the “Annual Meeting”). The Company is providing this supplement to the Proxy Statement (this “Supplement”) to, among other things, (1) change the date and time of the Annual Meeting to July 22, 2025 at 11:00 a.m. Pacific Time, (2) change the Record Date to May 30, 2025, (3) change the mailing date of the Proxy Statement to June 6, 2025, (4) update the voting approval standard relating to the Reverse Stock Split Proposal and (5) make other conforming edits to the Proxy Statement. This Supplement should be read together with the Proxy Statement. Any terms used and not defined herein have the meanings assigned to them in the Proxy Statement. Except as set