Company: RVRC
Filing Date: 2025-08-13
Form Type: S-1/A
Source: 0001213900-25-075747
Chunk: 87

Company: Revium Rx.
Filing Date: 2025-08-13
Form: S-1/A
Chunk 87
---
. Therapeutic potential of injectable nano-mupirocin liposomes against MRSA and VRE infections. 
 Pharmaceutics. 2021;13(11):1789. PMC8706398                                                       |

| 4. | He W, et al. Enhanced                                                                      
 uptake of antibiotic-loaded nanoparticles by macrophages improves intracellular killing of 
 pathogens. Journal of Controlled Release. 2021;336:149–162.                                |

| 5. | WHO. WHO Bacterial                                                                   
 Priority Pathogens List, 2024. https://www.who.int/publications/i/item/9789240093461 |

| 6. | Cern                                                                                            
 A, Connolly KL, Jerse AE, Barenholz Y. In Vitro Susceptibility of Neisseria gonorrhoeae Strains 
 to Mupirocin, an Antibiotic Reformulated for Parenteral Administration in Nanoliposomes.        
 Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02377-17. https://doi.org/10.1128/aac.02377-17  |

| 7. | O. Goldmann, A.                                                                                                       
 Cern, M. Muesken, et al., Liposomal mupirocin holds promise for systemic treatment of invasive                        
 Staphylococcus aureus infections, Journal of Controlled Release (2019), https://doi.org/10.1016/j.jconrel.2019.11.007 |

<div align='center'>53</div>

IP protection.

Several patents and licenses for Nano-Mupirocin
were already obtained in major countries and regions, including the U.S., Europe (in the table referred to as European Patent Office
– EP), Japan, India and China

All below patents are composition
of matter patents

| Status  
 Granted 
 Granted 
 Granted |     | Country 
 US      
 EP      
 EP-BE   |     | Application   
 Date          
 Oct. 10, 2016 
 Oct. 11, 2016 
 Oct. 11, 2016 |     | Title (with         
 embodiment          
 where applicable)   
 Liposomal Mupirocin 
 Liposomal Mupirocin 
 Liposomal Mupirocin |     |  Publication 
       Number 
 2017/0027869 
      3142642 
      3142642 |     | Patent Date       
 June 26, 2018