Company: SMNR
Filing Date: 2025-08-13
Form Type: 424B3
Source: 0001193125-25-179226
Chunk: 931

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-08-13
Form: 424B3
Chunk 931
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                              |     | Name: Jaisim Shah              |
|                              |     | Title: Chief Executive Officer |

[Signature Page to the Agreement and Plan of Merger] A-1-61

Annex A-2

AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER

THIS AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER (this “”), dated as of April 16, 2025, is made and entered
into by and among Denali Capital Acquisition Corp., a Cayman Islands exempted company (which shall migrate to and domesticate as a Delaware corporation prior to the Closing, “”), Denali Merger Sub Inc., a Delaware
corporation and wholly owned subsidiary of Parent (the “” and together with Parent, collectively, the “”), and Semnur Pharmaceuticals, Inc., a Delaware corporation (the
“”).

WHEREAS, the Parent Parties and the Company have entered into an Agreement and Plan of Merger, dated as of
August 30, 2024 (the “”), providing for, among other things, the merger of Merger Sub with and into the Company, with the Company continuing as the Surviving Corporation;

WHEREAS, pursuant to Section 10.2(a) of the Merger Agreement, the Merger Agreement may be amended by a writing signed by each of the
Parent Parties and the Company; and

WHEREAS, each of the Parent Parties and the Company desire to amend the Merger Agreement in certain
respects as described in this Amendment.

NOW, THEREFORE, in consideration of the premises set forth above, which are incorporated in this
Amendment as if fully set forth below, and intending to be legally bound hereby, the parties hereto accordingly agree as follows.

1. . Except as otherwise indicated herein or unless the context otherwise requires, capitalized terms used but not
defined herein shall have the meanings ascribed thereto in the Merger Agreement.

2. .

(a) The following definitions are hereby added to Article I of the Merger Agreement in alphabetical order:

““” means that certain Amendment No. 1 to the Merger Agreement, dated as of
April 16, 2025, by and among Parent, Merger Sub and the Company.”

““” means the de-listing of the Parent Units, Class A Shares and Parent Warrants from trading on Nasdaq for any reason, including due to the failure of
Parent to satisfy Nasdaq’s continued listing requirements