Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 116

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 116
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 settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be
governed by the final adjudication of such issue.

(c) The undersigned registrant hereby undertakes that:

(1) That for purposes of determining any liability under the Securities Act, the information omitted from the form of prospectus filed as part
of this registration statement in reliance upon Rule 430A and contained in a form of prospectus filed by the registrant pursuant to Rule 424(b)(1) or (4), or 497(h) under the Securities Act shall be deemed to be part of this registration statement
as of the time it was declared effective.

(2) That for the purpose of determining any liability under the Securities Act, each
post-effective amendment that contains a form of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof.

II-5

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form F-1and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Edinburgh, United Kingdom, on April 29, 2025.

| NUCANA, PLC |     |                                |
| By:         |     | /s/ Hugh S. Griffith           |
|             |     | Name: Hugh S. Griffith         |
|             |     | Title: Chief Executive Officer |

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

| Signature            
 /s/ Hugh S. Griffith 
 Hugh S. Griffith     
 /s/ Ian Webster      
 Ian Webster          |     | Title                                        
 Chief Executive Officer and Director         
 (Principal Executive Officer)                
 Director of Finance                          
 (Principal Financial and Accounting Officer) |     | Date           
 April 29, 2025 
 April 29, 2025 |
|:---------------------|:----|:---------------------------------------------|:----|:---------------|
| * Andrew             
 Kay                  |     | Chairman                                     |     | April 29, 2025 |
| * Bali               
 Muralidhar