Company: SCLXW
Filing Date: 2025-02-26
Form Type: PRER14A
Source: 0001193125-25-036730
Chunk: 43

Company: Scilex Holding Co
Filing Date: 2025-02-26
Form: PRER14A
Chunk 43
---
uciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer. |     |                                                                                                                                                                                                                                                                                                                                   |     |     |     |         |     |         |

| Signature [PLEASE SIGN WITHIN BOX] |     | Date |     | Signature (Joint Owners) |     | Date |

You are cordially invited to attend our 2025 Special Meeting of Stockholders,

to be held virtually, via live webcast at www.virtualshareholdermeeting.com/SCLX2025SM

at 9:00 AM Pacific Time on Wednesday, March 19, 2025.

Important Notice Regarding the Availability of Proxy Materials for the Special Meeting:

The Proxy Statement is available at www.proxyvote.com.

— — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — —

V64342-S09806

SCILEX HOLDING COMPANY

Special Meeting of Stockholders

March 19, 2025 9:00 AM Pacific Time

This proxy is solicited by the Board of Directors

The stockholder(s) hereby appoint(s) Jaisim Shah and Henry Ji, Ph.D., or any of them, as proxies, each with the power
to appoint his substitute, and hereby authorize(s) them to represent and to vote, as designated on the reverse side of this ballot, all of the shares of Common Stock and Preferred Stock of SCILEX HOLDING COMPANY that the stockholder(s) is/are
entitled to vote at the Special Meeting of Stockholders to be held at 9:00 AM Pacific Time on March 19, 2025, via live webcast at www.virtualshareholdermeeting.com/SCLX2025SM and any adjournments or postponements thereof.

This proxy, when properly executed, will be voted in the manner directed herein. If no such direction is made, this proxy will be voted in accordance with the Board of Directors’ recommendations. In their discretion, the proxies are authorized to vote upon such other business as may properly come before the meeting or any adjournments or postponements thereof.

Please note, there will be no physical location for the meeting. To attend the meeting live via the Internet, please go to www.virtualshareholdermeeting.com/SCL