Company: XOMAP
Filing Date: 2025-10-03
Form Type: 424B5
Source: 0001193125-25-230383
Chunk: 41

Company: XOMA Royalty Corp
Filing Date: 2025-10-03
Form: 424B5
Chunk 41
---
. We may also use a portion of the net proceeds to acquire or invest in businesses, products and technologies that are complementary to our
own, although we have no commitments or agreements with respect to any acquisitions as of the date of this prospectus. Our expected use of proceeds from the sale of the securities offered hereby represents our current intentions based on our present
plans and business condition. As of the date of this prospectus, we cannot predict with certainty all of the particular uses for the proceeds to be received from the sale of the securities offered hereby or the amounts that we will actually spend on
the uses set forth above.

Pending the use of the net proceeds, we intend to temporarily invest the proceeds in short-term, interest-bearing instruments.
When we offer and sell the securities to which this prospectus relates, the prospectus supplement related to such offering will set forth our intended use of the proceeds, if any, received from the sale of such securities.

5

DESCRIPTION OF SECURITIES WE MAY OFFER We may offer any combination of the following securities, with a total value of up to $200,000,000, from time to time in one or more offerings under this prospectus at prices and on terms to be determined at the time of any offering:

| • |     | common stock; |

| • |     | preferred stock; |

| • |     | depositary shares; |

| • |     | debt securities; |

| • |     | warrants to purchase common stock, preferred stock, depositary shares or debt securities, or; |

| • |     | subscription rights to purchase common stock, preferred stock, depositary shares or debt securities; |

| • |     | contingent value rights; |

| • |     | royalty certificates; and |

| • |     | units comprised of any combination of our common stock, preferred stock, depositary shares, debt securities, 
 warrants, subscription rights, contingent value rights and royalty certificates.                             |

This prospectus provides you with a general description of the securities we may offer. Each time we offer a type or series of securities under this prospectus, we will provide a prospectus supplement that will describe the specific amounts, prices and other important terms of the securities, including, to the extent applicable:

| • |     | designation or classification; |

| • |     | aggregate principal amount or aggregate offering price; |

| • |     | maturity date, if applicable; |

| • |     | original issue discount, if any; |

| • |