Company: ARWR
Filing Date: 2025-03-07
Form Type: 424B7
Source: 0001193125-25-049889
Chunk: 25

Company: ARROWHEAD PHARMACEUTICALS, INC.
Filing Date: 2025-03-07
Form: 424B7
Chunk 25
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 would have been the case otherwise.                                                                                                                            |

In addition, the indenture will permit us to terminate substantially all our respective obligations under the indenture as they relate to a particular series of debt securities by depositing with the trustee money or government obligations sufficient to pay all principal and interest on such series at its maturity or redemption date if the debt securities of such series will become due and payable at maturity within one year or are to be called for redemption within one year of the deposit. Transfer and Exchange A holder will be able to transfer or exchange debt securities only in accordance with the indenture. The registrar may require a holder, among other things, to furnish appropriate endorsements and transfer documents, and to pay any taxes and fees required by law or permitted by the indenture. Amendment, Supplement and Waiver Without notice to or the consent of any holder, we and the trustee may amend or supplement the indenture or the debt securities of a series to:

| • |     | cure any ambiguity, omission, defect or inconsistency; |

| • |     | comply with the provisions of the indenture regarding the consolidation, merger, sale, lease, conveyance or other 
 disposition of all or substantially all of our assets;                                                            |

| • |     | provide that specific provisions of the indenture shall not apply to a series of debt securities not previously                                                                                                 
 issued or to make a change to specific provisions of the indenture that only applies to any series of debt securities not previously issued or to additional debt securities of a series not previously issued; |

| • |     | create a series and establish its terms; |

| • |     | provide for uncertificated debt securities in addition to or in place of certificated debt securities; |

| • |     | add a guarantor subsidiary in respect of any series of debt securities; |

| • |     | secure any series of debt securities; |

| • |     | comply with requirements of the SEC in order to effect or maintain the qualification of the indenture under the 
 Trust Indenture Act;                                                                                            |

11

| • |     | make any change that does not adversely affect the rights of any holder; or |

| • |     | conform the provisions of the indenture to the final offering document in respect of any series of debt 
 securities.                                                                                             |

With the exceptions discussed below, we and the trustee may amend or supplement the indenture or the debt securities of a particular series with the written consent of the holders of at least a majority in principal amount