Company: APM
Filing Date: 2025-12-05
Form Type: 424B5
Source: 0001213900-25-118752
Chunk: 401

Company: Aptorum Group Ltd
Filing Date: 2025-12-05
Form: 424B5
Chunk 401
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 an entity treated as a partnership or other pass-through entity for U.S. federal income
tax purposes, such owner will be considered a “Non-U.S. Holder.” The material U.S. federal income tax consequences applicable
specifically to Non-U.S. Holders are described below under the heading “Non-U.S. Holders.”

This brief summary is based
upon existing provisions of the Internal Revenue Code of 1986, as amended, or the “Code,” Treasury regulations promulgated
thereunder, published revenue rulings and procedures of the U.S. Internal Revenue Service, or the “IRS,” and judicial decisions,
all as currently in effect. These authorities are subject to change or differing interpretations, possibly on a retroactive basis.

This discussion does not address
all aspects of U.S. federal income taxation that may be relevant to any particular holder based on such holder’s individual circumstances.
In particular, this discussion considers only holders that own Company shares, or who will own and hold Company shares as a result of
owning the corresponding DiamiR shares, as capital assets within the meaning of Section 1221 of the Code. This discussion does not address
the alternative minimum tax or the U.S. federal income tax consequences to holders that are subject to special rules, including:

| ● | financial institutions or financial services entities; |

| ● | broker-dealers; |

| ● | persons that are subject to the mark-to-market accounting rules under Section 475 of the Code; |

| ● | tax-exempt entities; |

| ● | governments or agencies or instrumentalities thereof; |

| ● | insurance companies; |

| ● | regulated investment companies; |

| ● | real estate investment trusts; |

| ● | certain expatriates or former long-term residents of the United States; |

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| ● | Non-U.S. Holders (except as specifically provided below); |

| ● | persons that actually or constructively own five percent (5%) or more of Company shares or voting securities (except as specifically provided below); |

| ● | persons that acquired Company shares pursuant to an exercise of employee options, in connection with employee incentive plans or otherwise as compensation; |

| ● | persons that hold Company shares as part of a straddle, constructive sale, hedging, redemption or other integrated transaction; |

| ● | persons whose functional currency is not the U.S. dollar; |

| ● | controlled foreign corporations; or |

| ● | passive foreign investment companies.