Company: BLTE
Filing Date: 2025-12-02
Form Type: 424B5
Source: 0001104659-25-117702
Chunk: 2

Company: BELITE BIO, INC
Filing Date: 2025-12-02
Form: 424B5
Chunk 2
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 Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus supplement. Any representation to the contrary is a criminal offense.**

| ​                                        | ​ | ​ | Per ADS |     |        |   | ​ | ​ | Total |     |                |   | ​ |
| Public offering price                    | ​ | ​ | ​       | US$ | 154.00 | ​ | ​ | ​ | ​     | US$ | 349,999,958.00 | ​ | ​ |
| Underwriting discounts and commission(1) | ​ | ​ | ​       | US$ |   9.24 | ​ | ​ | ​ | ​     | US$ |  20,999,997.48 | ​ | ​ |
| Proceeds, before expenses, to us         | ​ | ​ | ​       | US$ | 144.76 | ​ | ​ | ​ | ​     | US$ | 328,999,960.52 | ​ | ​ |

**(1) See “Underwriters” for a description of the compensation payable to the underwriters. The underwriters have an option to purchase up to an aggregate of 340,909 additional ADSs from us at the public offering price, less underwriting discounts and commissions, exercisable within 30 days from the date of this prospectus supplement. Delivery of the ADSs is expected to be made on or about December 3, 2025.**

| ​ | Morgan Stanley | ​ | ​ | Leerink Partners | ​ | ​ | BofA Securities | ​ | ​ | Cantor | ​ |

| ​ | H.C. Wainwright & Co. | ​ | ​ | Maxim Group LLC | ​ | ​ | Titan Partners Group                    | ​ |
| ​ | ​                     | ​ | ​ | ​               | ​ | ​ | a division of American Capital Partners | ​ |

The date of this prospectus supplement is December 1, 2025

TABLE OF CONTENTS TABLE OF CONTENTS Prospectus Supplement

| ​ | ABOUT THIS PROSPECTUS                               | ​ | ​ | ​ | ​ | S-1  | ​ | ​ |
| ​ | CAUTIONARY NOTE REGARDING FORWARD-LOOKINGSTATEMENTS | ​ | ​ | ​ | ​ | S-2  | ​ | ​ |
| ​ | PROSPECTUS SUPPLEMENT SUMMARY                       | ​ | ​ | ​ | ​ | S-