Company: TAK
Filing Date: 2025-06-26
Form Type: 424B5
Source: 0001395064-25-000101
Chunk: 24

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-26
Form: 424B5
Chunk 24
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 determining the redemption price shall be conclusive and binding for all purposes, absent manifest error.

#### Optional Tax Redemption
Each series of the Notes may be redeemed at any time, at the Issuer’s option and sole discretion, in whole, but not in part, at the principal amount of the Notes together with interest accrued to the date fixed for redemption and any additional amounts thereon, if the Issuer or the Guarantor has been or will be obliged to pay any additional amounts with respect to such series as a result of certain changes in tax law, as described further under “Description of Senior Debt Securities and Guarantee—Optional Tax Redemption” in the accompanying prospectus.

#### Paying and Transfer Agent and Notes Registrar
The Bank of New York Mellon, located in New York, New York, will initially act as paying and transfer agent and registrar for the Notes. The Issuer or the Guarantor may change the paying agent, transfer agent or registrar without prior notice to the holders of the Notes, and the Issuer, the Guarantor or any of their affiliates may act as paying agent, transfer agent or registrar.

#### Clearance and Settlement
The Notes have been accepted for clearance through DTC, Euroclear and Clearstream.

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### TAXATION

#### Japanese Taxation
The following general description of certain aspects of Japanese taxation (limited to those regarding national taxes) is applicable to the Notes to be offered or sold outside Japan. It is not intended to constitute a complete analysis of all the tax consequences relating to the purchase, ownership and disposition of the Notes. Prospective purchasers should consult their own tax advisers as to the exact tax consequences of their particular situations.

The payment of principal and interest in respect of the Notes to an individual non-resident of Japan or a non-Japanese corporation will not, in general, be subject to any Japanese income tax or corporation tax, unless the receipt of the relevant payment is the income of such individual non-resident or non-Japanese corporation from sources in Japan and/or TPC is deemed to be an issuer of the Notes.

The tax treatment of interest and the redemption gain arising from the payment by TPC under the Guarantee to an individual non-resident of Japan or a non-Japanese corporation having no permanent establishment within Japan is unclear under Japanese law , especially when net proceeds from the offering of the Notes are used for TPC’s business in Japan (see “Use of Proceeds”). If the interest is considered to be from a source in Japan, the payment may be