Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063899
Chunk: 273

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 273
---
 Hispanics are about one and one-half times as likely to 
 have Alzheimer’s or other dementias as older Whites.          |

| ● | People younger than 65 can also develop Alzheimer’s dementia.                                                                                 
 Although prevalence studies are limited, researchers believe about 110 of every 100,000 people age 30 to 64 years, or about 200,000 Americans 
 in total, have younger-onset dementia.                                                                                                        |

| ● | Someone in the US develops AD                                                                                     
 every 67 seconds and by 2050 one new case of AD is expected to develop every 33 seconds (~1M new cases per year); |

| ○ | Deaths due to Alzheimer’s                                              
 disease between 2000 and 2019 have more than doubled, increasing 145%. |

| ○ | Among people aged 70, 61% of those                                                                                     
 with Alzheimer’s dementia are expected to die before age 80, compared with 30% of people without Alzheimer’s dementia. |

<div align='center'>141</div>

| ● | This results in a significant                                      
 cost burden to families, and payors such as Medicare and Medicaid: |

| ○ | In 2025, total payments for all individuals with Alzheimer’s disease or other dementias are estimated at $384 billion (not including unpaid caregiving).                                                                                     |
| ○ | Medicare and Medicaid are expected to cover $245 billion, or 64%, of the total health care and long-term care payments for people with Alzheimer’s disease or other dementias. Out-of-pocket spending is expected to be around $97B in 2025. |
| ○ | Total payments for health care, long-term care and hospice care for people with Alzheimer’s disease and other dementias are projected to increase to nearly $1 trillion in 2050.                                                             |
| ○ | The total lifetime cost of care for someone with dementia is estimated at $371,621.                                                                                                                                                          |

The figure below, adapted from the Alzheimer’s Association Report
presents percentage changes in selected causes of death between 2000 and 2022 (all ages). While the proportion of deaths from heart disease,
stroke, breast and prostate cancer, and HIV decreased, the proportion of deaths from AD in the US increased by over 140%.

<div align='center'>Percentage Changes in Selected Causes of Death (All Ages) in the US between 2000 and 2022</div>

Over the past 20 years, several investig