Company: PACB
Filing Date: 2025-04-23
Form Type: DEF 14A
Source: 0001299130-25-000090
Chunk: 106

Company: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
Filing Date: 2025-04-23
Form: DEF 14A
Chunk 106
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 in “ Compensation Discussion and Analysis.” Revenue means all GAAP-based revenue as reflected in our audited financial statements.

### Most Important Financial Performance Measures
The financial performance measures listed below represent the most important financial performance measures that were used to determine the compensation actually paid to our NEOs in 2024. No other financial performance measures were used to determine compensation actually paid to our NEOs for 2024.

| Revenue                                           |
| Cash, cash equivalents and short-term investments |

Relationship Between Compensation Actually Paid (CAP) and Performance Measures

The Pay Versus Performance table above and graphs below demonstrate that our executives’ CAP is generally aligned with our corporate performance over time. Specifically:

| • |     | PEO and Non-PEO NEOs’ pay is strongly aligned with revenue. Each year, PEO and NEO CAP generally fluctuated with our revenue. |

| 2025 Proxy Statement |     | 76 |

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| • |     | Our revenue, which increased from $78.9 million in 2020 to $154.0 million in 2024, moved in conjunction with PEO and Non-PEO NEOs’ CAP. |

Other than for fiscal year 2024, PacBio’s TSR has either tracked with or outperformed the TSR of the Nasdaq Biotechnology Index peer group year-over-year.

Description of Relationship Between PEO and Non-PEO NEO Compensation Actually Paid (in millions) and Company and Nasdaq Biotechnology Index ( “ NBI ” ) TSR (12/31/2019 indexed to $100)

The following chart sets forth the relationship between Compensation Actually Paid to our PEOs and the average of Compensation Actually Paid to our Non-PEO NEOs, versus the Company’s cumulative TSR and the NBI TSR, as applicable, over the five most recently completed fiscal years.

Description of Relationship Between PEO and Non-PEO NEO Compensation Actually Paid (in millions) and Net Income (Loss)

The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs and our Net Income (Loss) during the five most recently completed fiscal years.

| 2025 Proxy Statement |     | 77 |

TABLE OF CONTENTS

Although Item 402(v) of Regulation S-K requires the description of the relationship between the compensation actually paid for our NEOs and our net income (loss), we do not currently utilize GAAP or non-GAAP net income (loss