Company: EDSA
Filing Date: 2025-05-28
Form Type: S-8
Source: 0001171843-25-003499
Chunk: 1

Company: Edesa Biotech, Inc.
Filing Date: 2025-05-28
Form: S-8
Chunk 1
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 standards
provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

<div align='center'>EXPLANATORY NOTE</div>

This Registration Statement
on Form S-8 is filed by Edesa Biotech, Inc., a British Columbia corporation (the “Registrant”), relating to
1,725,000 common shares, no par value per share (the “Common Shares”), issuable under the Edesa Biotech, Inc.
2019 Equity Incentive Compensation Plan (the “Plan”), which Common Shares are in addition to (i) the 164,736
Common Shares registered on the Registrant’s Form S-8 filed on January 28, 2020 (Registration No. 333-236121), (ii) the 213,858
Common Shares registered on the Registrant’s Form S-8 filed on April 23, 2021 (Registration No. 333-255485), (iii) the 197,143 Common
Shares registered on the Registrant’s Form S-8 filed on May 24, 2023 (Registration No. 333-272176), and (iv) the 67,000 Common Shares
registered on the Registrant’s Form S-8 filed on May 31, 2024 (Registration No. 333-279887) (collectively, the “Prior Registration Statements”).

This Registration Statement relates
to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with General
Instruction E to Form S-8 regarding Registration of Additional Securities. Pursuant to Instruction E of Form S-8, the contents of the
Prior Registration Statements are incorporated herein by reference and made part of this Registration Statement, except as amended hereby.

All share amounts referenced
above and otherwise in this Registration Statement give effect to a 1-for-7 reverse split of the Common Shares
effected on October 11, 2023.

<div align='center'>Part II

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>

Item 3. Incorporation of Documents by Reference

The following documents, which
previously have been filed by the Registrant with the Securities and Exchange Commission (the “Commission”)
pursuant to the Securities Exchange Act of 1934, as amended (the “Exchange Act”), are incorporated by reference
herein and shall be deemed to be a part hereof:

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