Company: AGIO
Filing Date: 2025-04-25
Form Type: DEF 14A
Source: 0001193125-25-096719
Chunk: 105

Company: AGIOS PHARMACEUTICALS, INC.
Filing Date: 2025-04-25
Form: DEF 14A
Chunk 105
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average number of shares outstanding. Set forth below is a table that reflects our burn rate for the 2024, 2023 and 2022 calendar years, as well as an average over those years.

|                    |     |   Options 
   Granted |     |   Full Value 
 Awards (RSU, 
 PSU) Granted |     | Awards Granted |     | Basic Weighted 
 Average Number 
   of Shares of 
   Common Stock 
    Outstanding |     | Gross Burn 
 Rate       |     |
| Calendar Year      |     |        -

# |     |           -# |     |             -# |     |             -# |     | % (1)      |     |
| 2024               |     | 1,050,087 |     |    1,327,164 |     |      2,377,251 |     |     56,807,415 |     |            | 4.2 |
| 2023               |     |   886,795 |     |    1,040,840 |     |      1,927,635 |     |     55,651,487 |     |            | 3.5 |
| 2022               |     | 1,850,093 |     |    1,207,009 |     |      3,057,102 |     |     54,789,435 |     |            | 5.6 |
| Three-Year Average |     | 1,262,325 |     |    1,191,671 |     |      2,453,996 |     |     55,749,446 |     |            | 4.4 |

| (1) | We define “gross burn rate” as the number of equity awards granted in the year divided by the basic weighted average number of shares of common stock outstanding. For purposes of this calculation, for each year, we counted the number of equity awards subject to any performance-based achievement based on the maximum number of shares of our common stock issuable under such awards. |

Finally, in developing the share request for the 2023 Plan Amendment, we considered that, as of March 31, 2025, 82% of our outstanding stock options had an exercise price greater than our stock price and therefore had no intrinsic value. Thus, a significant portion of the outstanding equity awards that we have granted are not, in fact, currently serving to