Company: NCNA
Filing Date: 2025-05-05
Form Type: CORRESP
Source: 0001193125-25-112633
Chunk: 0

Company: NuCana plc
Filing Date: 2025-05-05
Form: CORRESP
Chunk 0
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NUCANA PLC 3 Lochside Way Edinburgh, EH12 9DT United Kingdom May 5, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attention: Joshua Gorsky and Tim Buchmiller

| Re: |     | NuCana plc                                         |
|     |     | Registration Statement on Form F-1, as amended     |
|     |     | File No. 333-286716 (the “Registration Statement”) |
|     |     | Acceleration Request                               |

Ladies and Gentlemen: In accordance with Rule 461 of the Rules and Regulations promulgated under the Securities Act of 1933, as amended, NuCana plc (the “Registrant”) hereby respectfully requests that the Securities and Exchange Commission accelerate the effective date of the above-referenced Registration Statement to Monday, May 5, 2025, at 5:00 p.m., Eastern Time, or as soon as thereafter practicable. The cooperation of the staff in meeting the timetable described above is very much appreciated. Please contact John T. Rudy of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C., counsel to the Registrant, at (617) 348-3050with any questions regarding this request.

| Very truly yours,       |
| NUCANA PLC              |
| /s/ Hugh S. Griffith    |
| Hugh S. Griffith        
 Chief Executive Officer |

| cc: | Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. |

John T. Rudy, Esq.