Company: HURA
Filing Date: 2025-11-03
Form Type: S-3
Source: 0001193125-25-262843
Chunk: 75

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-11-03
Form: S-3
Chunk 75
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 a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer 
 or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the  
 opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act of 1933 and will  
 be governed by the final adjudication of such issue.                                                                                                                                                                                                     |

| (d) | The undersigned registrant hereby undertakes to file an application for the purpose of determining the                                                                                                                                  
 eligibility of the trustee to act under subsection (a) of Section 310 of the Trust Indenture Act in accordance with the rules and regulations prescribed by the Securities and Exchange Commission under Section 305(b)(2) of the Trust 
 Indenture Act.                                                                                                                                                                                                                          |

II-6

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Tampa, State of Florida, on November 3, 2025.

| TUHURA BIOSCIENCES, INC. |     |                              |
| By:                      |     | /s/ James A. Bianco          |
|                          |     | James A. Bianco, M.D.        |
|                          |     | Chief Executive Officer      |
|                          |     | -Principal Executive Officer |

KNOW ALL MEN BY THESE PRESENTS, that the undersigned hereby constitute and appoint James A. Bianco, M.D. as the true and lawful attorney-in-factof the undersigned, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign this registration statement and any or all amendments to this registration statement, including post-effective amendments, and registration statements filed pursuant to 462(b) under the Securities Act, and to file or cause to be filed the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting