Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 107

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 107
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ifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form F-1and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Edinburgh, United Kingdom, on , 2025.

| NUCANA, PLC |     |                                |
| By:         |     |                                |
|             |     | Name: Hugh S. Griffith         |
|             |     | Title: Chief Financial Officer |

POWER OF ATTORNEY KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Hugh S. Griffith and Ian Webster, and each of them, as his true and lawful attorneys-in-factand agents, each with the full power of substitution, for him and in his name, place or stead, in any and all capacities, to sign any and all amendments to this registration statement (including post-effective amendments), and to sign any registration statement for the same offering covered by this registration statement that is to be effective upon filing pursuant to Rule 462(b) promulgated under the Securities Act of 1933, and all post-effective amendments thereto, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-factand agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-factand agents, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

| Signature         |     | Title                                        |     |   Date |
| Hugh S. Griffith  |     | Chief Executive Officer and Director         
 (Principal Executive Officer)                |     | , 2025 |
| Ian Webster       |     | Director of Finance                          
 (Principal Financial and Accounting Officer) |     | , 2025 |
| Andrew Kay        |     | Chairman                                     |     | , 2025 |
| Bali Muralidhar   |     | Director                                     |     | , 2025 |
| Cyrille Leperlier |     | Director                                     |     |