Company: APM
Filing Date: 2025-10-06
Form Type: S-4
Source: 0001213900-25-096656
Chunk: 243

Company: Aptorum Group Ltd
Filing Date: 2025-10-06
Form: S-4
Chunk 243
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/mrsa/tracking/index.html). Both adults and children may carry MRSA. Most MRSA infections occur in people who have been in hospital or other health care settings, such as nursing homes and dialysis centers (source: https://www.mayoclinic.org/diseases -conditions /mrsa/symptoms -causes /syc -20375336), which is known as Healthcare -AssociatedMRSA (“HA -MRSA”). HA -MRSAinfections are typically associated with invasive procedures or devices, such as surgeries, intravenous tubing or artificial joints. Another type of MRSA infection, 122 known as Community -AssociatedMRSA (“CA -MRSA”), has occurred in wider community among healthy people. It often begins as a painful skin boil and spreads by skin -to-skincontact. About 85% of serious, invasive MRSA infections are healthcare associated infections ( https://www.cdc.gov/media/pressrel/2007/r071016.htm). The incidence of CA -MRSAvaries according to population and geographic location. In the U.S., more than 94,000 people develop serious MRSA infection and about 19,000 patients die asva result each year ( https://www.cdc.gov/media/pressrel/2007/r071016.htm). According to the US Centers for Disease Control and Prevention (“CDC”), Staphylococcus aureus, including MRSA, caused about 11% of healthcare -associatedinfections in 2011 (source: http://www.healthcommunities.com/mrsa -infection /incidence.shtml). Each year in the U.S., around one out of every twenty -fivehospitalized patients contracts at least one infection in the hospital (N Engl J Med. 2014, 27;370(13):1198 -208). In the U.S., there were over 80,000 invasive MRSA infections and 11,285 related deaths in 2011 (source: https://edition.cnn.com/2013/06/28/us/mrsa -fast-facts /index.html). Indeed, severe MRSA infections most commonly occur during or soon after inpatient medical care. More than 290,000 hospitalized patients are infected with Staphylococcus aureus and of these staphylococcal infections, approximately 126,000 are related to MRSA (source: http://www.healthcommunities.com/mrsa -infection /incidence.shtml). ALS -4is a small drug molecule