Company: PACB
Filing Date: 2025-08-07
Form Type: S-8
Source: 0001299130-25-000158
Chunk: 1

Company: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
Filing Date: 2025-08-07
Form: S-8
Chunk 1
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If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. o

### EXPLANATORY NOTE
This Registration Statement is being filed for the purpose of registering an additional 23,000,000 shares of common stock that were reserved for issuance under Pacific Biosciences of California, Inc.’s (the “Company’s”) 2020 Equity Incentive Plan (the “2020 EIP”). The Registrant previously filed with the Securities and Exchange Commission (the “Commission”) registration statements on Form S-8 on August 6, 2020 (SEC File No. 333-241687), May 26, 2022 (SEC File No. 333-265249) and June 20, 2024 (SEC File No. 333-280353) (the “Prior Registration Statements”) registering shares of Common Stock issuable under the 2020 EIP. This Registration Statement relates to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with General Instruction E of Form S-8 regarding Registration of Additional Securities. Pursuant to General Instruction E of Form S-8, the contents of the Prior Registration Statements are incorporated herein by reference and made part of this Registration Statement, except for Items 3 and 8, which are being updated by this Registration Statement.

# PART I

### INFORMATION REQUIRED IN THE PROSPECTUS
The documents containing the information specified in Item 1 and Item 2 of this Registration Statement on Form S-8 (the “Registration Statement”) will be sent or given to employees, officers, directors or others as specified by Rule 428(b)(1) under the Securities Act of 1933, as amended (the “Securities Act”). In accordance with the rules and regulations of the Commission and the instructions to the Registration Statement, such documents are not being filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424.

# PART II

### INFORMATION REQUIRED IN REGISTRATION STATEMENT

## Item 3. Incorporation of Documents by Reference.
Pacific Biosciences of California, Inc. (the “Registrant”) hereby incorporates by reference into this Registration Statement the following documents previously filed with the Commission:

(1) The Registrant’s Annual Report on Form