Company: BWAY
Filing Date: 2025-04-22
Form Type: 20-F
Source: 0001171843-25-002347
Chunk: 122

Company: Brainsway Ltd.
Filing Date: 2025-04-22
Form: 20-F
Item: Item 5
Chunk 122
---
tremor, dry mouth, nausea, constipation, visual changes, sweating, and sexual dysfunction. All other OCD medications may cause similar
side effects, which make it challenging for patients to retain a high quality of life while also working toward disease remission. Upon
initiation of pharmacological treatment for OCD, it is critical to closely monitor for development of any adverse effects.

Psychotherapy can be an effective treatment for adults
and children with OCD. The treatment may involve controlled exposure to the source of the obsession and practice of refraining from performance
of the compulsion. Research shows that certain types of psychotherapy, including cognitive behavior therapy (CBT) and other related therapies
(e. g., habit reversal training) can be as effective as medication for many individuals. Research also shows that a type of CBT called
Exposure and Response Prevention (EX/RP) is effective in reducing compulsive behaviors in OCD, even in people who did not respond well
to antidepressant medication. For many patients EX/RP is the add-on treatment of choice when antidepressant medication does not effectively
treat OCD symptoms.

  69  

Deep TMS presents a novel,
FDA-authorized treatment for OCD. In August 2018, the FDA classified and provided marketing authorization for Deep TMS for OCD as an adjunct
treatment (i. e., to be used in conjunction with first-line treatment, such as antidepressant medication or CBT) for adult patients suffering
from OCD. Deep TMS has the unique ability to simultaneously influence a network of specific regions in the brain related to OCD. In addition,
it offers a direct effect over deep regions in the brain associated with the disorder. The effects of the treatment begin within a relatively
short time period and the duration of the entire treatment plan is shorter compared to a medicinal treatment. Deep TMS therapy for OCD
has not demonstrated any systemic side effects, and we believe that Deep TMS presents an attractive alternative to existing treatment
options for OCD because antidepressant medications, due to their side effects, often lead to cessation of treatment by the patient and
as a result, relapse of OCD symptoms.

Positive data published in February 2022 in the Journal
of Psychiatric Research demonstrated the relative cost-effectiveness of Deep TMS for refractory OCD patients when compared with other
treatments within the treatment continuum, which includes outpatient medication, CBT, as well as more intensive, facility-based approaches.
The data suggest that Deep TMS is a cost-effective