Company: NCNA
Filing Date: 2025-06-18
Form Type: F-3/A
Source: 0001193125-25-142565
Chunk: 66

Company: NuCana plc
Filing Date: 2025-06-18
Form: F-3/A
Chunk 66
---
 require repayment and the registrant at its discretion exercises such right.

The registrant has
entered into indemnity agreements with its directors and executive officers, consistent with the indemnification arrangements permitted by the registrant’s Articles of Association, and intends to enter into indemnity agreements with any new
directors and executive officers in the future. These indemnity agreements may require the registrant, subject to the provisions of any relevant legislation, to indemnify the registrant’s directors and such officers against all costs, charges,
losses, expenses and liabilities incurred by such director or officer for negligence, default, breach of duty, breach of trust or otherwise in respect of such individual’s acts or omissions while in the course of acting or purporting to act as
a director or officer of the registrant or which otherwise arises by virtue of such director or officer holding or having held such a position.

The registrant has also purchased and maintains directors’ and officers’ liability insurance to insure, for the period of their
appointment, each of its directors and officers in respect of their appointments as directors or officers of the registrant.

Under the
Companies Act 2006, any provision (whether contained in a company’s articles of association or any contract or otherwise) that purports to exempt a director of a company, to any extent, from any liability that would otherwise attach to him in
connection with any negligence, default, breach of duty or breach of trust in relation to the company is void.

II-1

Item 9. Exhibits. The following exhibits are filed with this registration statement or are incorporated herein by reference.

| Exhibit 
 Number  |     | Exhibit Description                                                                                                                                                                              |     | Filed    
 Herewith |   |     | Incorporated        
 by Reference herein 
 from Form or        
 Schedule            |               |   |     | Filing 
 Date   |           |     | SEC File/   
 Reg. Number |            |
| 1.1*    |     | Form of Underwriting Agreement                                                                                                                                                                   |     |          |   |     |                     |               |   |     |        |           |     |             |            |
| 3.1     |     | Articles of Association of the registrant                                                                                                                                                        |     |          |   |     |                     | F-1           
 (Exhibit 3.1) |   |     |        | 4/24/2025 |     |             | 333-286716 |
| 4.1     |     | Form of