Company: NCNA
Filing Date: 2025-06-18
Form Type: F-3/A
Source: 0001193125-25-142565
Chunk: 15

Company: NuCana plc
Filing Date: 2025-06-18
Form: F-3/A
Chunk 15
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 plc and to effect certain amendments to our articles of association.

Our registered office is located at 77/78 Cannon Street, London, EC4N 6AF, United Kingdom. The principal legislation under which we
operate and our shares are issued is the Companies Act 2006.

Issued Share Capital

Our issued share capital as of June 16, 2025 was £9,832,543 divided into 9,540,891,147 ordinary shares and 15,040,465,803 deferred
shares, in each case, of £0.0004 each. A summary of increases in, and changes to, our issued share capital for the prior three years is set forth below.

During 2021 we issued 1,005,434 ordinary shares pursuant to the exercise of share options.

During 2022 we issued 192,908 ordinary shares pursuant to the exercise of share options.

During 2023 we issued 408,015 ordinary shares pursuant to our
“at-the-market” (ATM) sales agreement, and 79,433 ordinary shares pursuant to the exercise of share options.

On April 16, 2024, we effected a ratio change of our ADSs to our ordinary shares from one (1) ADS, representing one
(1) ordinary share, to one (1) ADS, representing twenty-five (25) ordinary shares. For our ADS holders, the change in the ADS ratio had the same effect as a
one-for-twenty-five reverse ADS split and had no impact on an ADS holder’s proportional equity interest in us.

During 2024, we issued 149,319 ordinary shares pursuant to the exercise of share options and 89,027,545 ordinary shares pursuant to our ATM
sales agreement.

Subsequent to December 31, 2024, we issued 9,857,575 ordinary shares pursuant to our ATM sales agreement, and
29,123 ordinary shares pursuant to the exercise of share options.

On April 23, 2025, we subdivided and redesignated the issued share
capital of the 151,923,897 ordinary shares of £0.04 each into 151,923,897 ordinary shares and 15,040,465,803 deferred shares, in each case, of £0.0004 each.

On May 7, 2025, under a registered direct offering, we issued 61,323,375 ordinary shares, and
Pre-Funded Warrants to purchase up to 209