Company: NCNA
Filing Date: 2025-06-18
Form Type: F-3/A
Source: 0001193125-25-142565
Chunk: 10

Company: NuCana plc
Filing Date: 2025-06-18
Form: F-3/A
Chunk 10
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 to time, discuss some of the factors that could contribute to these differences. These forward-looking statements include, among other things, statements about:

| • |     | the development of NUC-3373 and                                                                                                                            
 NUC-7738, as well as Acelarin, including statements regarding the expected initiation, timing, progress and availability of data from our clinical trials; |

| • |     | the potential attributes and benefit of our ProTides and their competitive positions; |

| • |     | our ability to successfully commercialize our ProTides, if approved; |

| • |     | our estimates regarding expenses, capital requirements and our need for additional financing; |

| • |     | our ability to acquire or in-license new product candidates; |

| • |     | potential collaborations; and |

| • |     | the duration and strength of our patent portfolio. |

We may not actually achieve the plans, intentions or expectations disclosed in our forward-looking statements, and you should not place undue reliance on our forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements we make. We have included important cautionary statements in this prospectus or in the documents incorporated by reference in this prospectus, particularly in the “Risk Factors” section, that we believe could cause actual results or events to differ materially from the forward-looking statements that we make. For a summary of such factors, please refer to the section titled “Risk Factors” in this prospectus, as updated and supplemented by the discussion of risks and uncertainties under “Risk Factors” contained in any supplements to this prospectus and in our most recent Annual Report on Form 20-F,as revised or supplemented by our subsequent periodic reports filed under the Exchange Act, as well as any amendments thereto, as filed with the SEC and which are incorporated herein by reference. The information contained in this document is believed to be current as of the date of this document. We do not intend to update any of the forward-looking statements after the date of this document to conform these statements to actual results or to changes in our expectations, except as required by law. In light of these assumptions, risks and uncertainties, the results and events discussed in the forward-looking statements contained in this prospectus or in any document incorporated herein by reference might not occur. Investors are cautioned not to place undue reliance on the forward-looking statements, which speak only as of the 6

date of this prospectus or the date of the document incorporated