Company: NCNA
Filing Date: 2025-06-18
Form Type: F-3/A
Source: 0001193125-25-142565
Chunk: 54

Company: NuCana plc
Filing Date: 2025-06-18
Form: F-3/A
Chunk 54
---
 • |     | all preemptive (and similar) rights, if any, with respect to such ordinary shares have been validly waived, 
 disapplied or exercised;                                                                                    |

| • |     | you are duly authorized to deposit the ordinary shares; |

| • |     | the ordinary shares presented for deposit are free and clear of any lien, encumbrance, security interest, charge,                                               
 mortgage or adverse claim, and are not, and the ADSs issuable upon such deposit will not be, “restricted securities” (as defined in the deposit agreement); and |

| • |     | the ordinary shares presented for deposit have not been stripped of any rights or entitlements. |

If any of the representations or warranties are incorrect in any way, we and the depositary may, at your cost and expense, take any and all actions necessary to correct the consequences of the misrepresentations. Transfer, Combination and Split Up of ADRs As an ADR holder, you will be entitled to transfer, combine or split up your ADRs and the ADSs evidenced thereby. For transfers of ADRs, you will have to surrender the ADRs to be transferred to the depositary and also must:

| • |     | ensure that the surrendered ADR is properly endorsed or otherwise in proper form for transfer; |

44

| • |     | provide such proof of identity and genuineness of signatures, and of such other matters contemplated in the 
 deposit agreement, as the depositary deems appropriate;                                                     |

| • |     | comply with applicable laws and regulations, including regulations imposed by us and the depositary consistent 
 with the deposit agreement, the ADR and applicable law;                                                        |

| • |     | provide any transfer stamps required by the State of New York or the United States; and |

| • |     | pay all applicable fees, charges, expenses, taxes and other government charges payable by ADR holders pursuant to 
 the terms of the deposit agreement, upon the transfer of ADRs.                                                    |

To have your ADRs either combined or split up, you must surrender the ADRs in question to the depositary with your request to have them combined or split up, and you must pay all applicable fees, charges and expenses payable by ADR holders, pursuant to the terms of the deposit agreement, upon a combination or split up of ADRs. Withdrawal of Ordinary Shares Upon Cancellation of ADSs As a holder, you will be entitled to present your