Company: FITBI
Filing Date: 2025-10-22
Form Type: 425
Source: 0001193125-25-247025
Chunk: 5

Company: FIFTH THIRD BANCORP
Filing Date: 2025-10-22
Form: 425
Chunk 5
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 to register the shares of Fifth Third common stock that will be issued to Comerica stockholders in connection with the proposed Transaction. The registration statement will include a joint proxy statement of Comerica and Fifth Third that also constitutes a prospectus of Fifth Third. The definitive joint proxy statement/prospectus will be sent to the stockholders of Comerica and shareholders of Fifth Third in connection with the proposed Transaction. INVESTORS AND SECURITY HOLDERS ARE URGED TO READ THE REGISTRATION STATEMENT ON FORM S-4AND THE JOINT PROXY STATEMENT/PROSPECTUS INCLUDED WITHIN THE REGISTRATION STATEMENT ON FORM S-4WHEN THEY BECOME AVAILABLE, AS WELL AS ANY OTHER RELEVANT DOCUMENTS FILED WITH THE SEC IN CONNECTION WITH THE TRANSACTION OR INCORPORATED BY REFERENCE INTO THE REGISTRATION STATEMENT ON FORM S-4AND THE JOINT PROXY STATEMENT/PROSPECTUS, BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION REGARDING COMERICA, FIFTH THIRD, THE TRANSACTION AND RELATED MATTERS. Investors and security holders may obtain free copies of these documents and other documents filed with the SEC by Comerica or Fifth Third through the website maintained by the SEC at https://www.sec.gov or by contacting the investor relations department of Comerica or Fifth Third at:

| Comerica Inc.                  |     | Fifth Third Bancorp           |
| Comerica Bank Tower            
 1717 Main Street, MC 6404      |     | 38 Fountain Square Plaza MD   
 1090FV                        |
| Dallas, TX 75201               |     | Cincinnati, OH 45263          |
| Attention: Investor Relations  |     | Attention: Investor Relations |
| InvestorRelations@comerica.com 
 (833) 571-0486                 |     | IR@53.com (866)               
 670-0468                      |

Before making any voting or investment decision, investors and security holders of Comerica and Fifth Third are urged to read carefully the entire registration statement and joint proxy statement/prospectus when they become available, including any amendments thereto, because they will contain important information about the proposed Transaction. Free copies of these documents may be obtained as described above.

PARTICIPANTS IN THE SOLICITATION

Comerica, Fifth Third and certain of their respective directors and executive officers may be deemed to be participants in the solicitation of
proxies from the stockholders of Comerica and shareholders of Fifth