Company: FITBI
Filing Date: 2025-11-05
Form Type: S-4
Source: 0001193125-25-267273
Chunk: 123

Company: FIFTH THIRD BANCORP
Filing Date: 2025-11-05
Form: S-4
Chunk 123
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 of directors; and |

| • |     | Fifth Third’s history and track record of realizing projected financial goals and benefits of acquisitions                                                          
 and the perceived strength of Fifth Third’s management and infrastructure to successfully complete the integration process following the completion of the mergers. |

The Comerica board of directors also considered potential risks related to the mergers but concluded that the anticipated benefits of the mergers were likely to substantially outweigh these risks. These potential risks include the following (which are presented below in no particular order and are not exhaustive):

| • |     | the regulatory and other approvals required in connection with the mergers and the bank mergers and the risk that 
 such regulatory approvals may not be received in a timely manner or at all or may impose unacceptable conditions; |

| • |     | the possibility of encountering difficulties in achieving anticipated revenue synergies and cost savings in the 
 amounts estimated or in the time frame contemplated;                                                            |

| • |     | the possibility of encountering difficulties in successfully maintaining existing customer and employee 
 relationships;                                                                                          |

85

| • |     | the possibility of encountering difficulties in successfully integrating Comerica’s and Fifth Third’s 
 business, operations and workforce;                                                                   |

| • |     | the risk of losing key Comerica or Fifth Third employees during the pendency of the mergers and thereafter; |

| • |     | the possible diversion of management attention and resources from the operation of Comerica’s business or 
 other strategic opportunities towards the completion of the mergers;                                      |

| • |     | the fact that the exchange ratio provides for a fixed number of shares of Fifth Third common stock and, as such,                                                                                                                                         
 Comerica stockholders cannot be certain, at the time of the Comerica special meeting, of the market value of the merger consideration they will receive, and the possibility that Comerica stockholders could be adversely affected by a decrease in the 
 market price of Fifth Third common stock before closing;                                                                                                                                                                                                 |

| • |     | the fact that the merger agreement places certain restrictions on the conduct of Comerica’s business prior                                                                                                                                           
 to the completion of the mergers, which are customary for public company merger agreements involving financial institutions, but which, subject to specific exceptions, could delay or prevent Comerica from undertaking business opportunities that 
 might arise or any other action it would otherwise take with respect to the operations of Comerica absent the pending completion of the mergers;                                                                                                     |

| • |     | certain anticipated merger-related