Company: PACB
Filing Date: 2025-03-17
Form Type: S-8
Source: 0001299130-25-000063
Chunk: 8

Company: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
Filing Date: 2025-03-17
Form: S-8
Chunk 8
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 as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Menlo Park, State of California, on March 17, 2025.

| PACIFIC BIOSCIENCES OF CALIFORNIA, INC. |     |                                             |
| By:                                     |     | /s/ Michele Farmer                          |
|                                         |     | Michele Farmer                              |
|                                         |     | Vice President and Chief Accounting Officer |

### POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Christian O. Henry, Brett Atkins and Michele Farmer, and each of them, as his or her true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for each individual in any and all capacities, to sign any and all amendments to this Registration Statement on Form S-8 of Pacific Biosciences of California, Inc., and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them, or the individual’s substitute, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, this report has been signed by the following persons on behalf of the Registrant in the capacities and on the dates indicated.

| Signature                 
 /s/ Christian O. Henry    |     | Title                                                                            
 Director, President, Chief Executive Officer and Interim Chief Financial Officer 
 (Principal Executive Officer and Principal Financial Officer)                    |     | Date           
 March 17, 2025 |
|:--------------------------|:----|:---------------------------------------------------------------------------------|:----|:---------------|
| Christian O. Henry        |     |                                                                                  |     |                |
| /s/ Michele Farmer        |     | Vice President and Chief Accounting Officer (Principal Accounting Officer)       |     | March