Company: SHPH
Filing Date: 2025-03-13
Form Type: 424B3
Source: 0001493152-25-010109
Chunk: 45

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-03-13
Form: 424B3
Chunk 45
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ilo disclaims beneficial ownership over all securities held by Mrs. Dritschilo    
 and PAL Trust.                                                                                                                         |
| (3) | Does                                                                                                                                   
 not include 28,455 RSUs that remain subject to vesting.                                                                                |
| (4) | Does not include 1,194 RSUs that remain subject to vesting.                                                                            |
| (5) | Does not include 209,791 RSUs that remain subject to                                                                                   
 vesting.                                                                                                                               |
| (6) | Does not include 184,162 RSUs that remain subject to                                                                                   
 vesting.                                                                                                                               |
| (7) | Based                                                                                                                                  
 on information provided in schedule 13G filed with the SEC on February 14, 2025 by Armistice Capital, LLC (“Armistice Capital”)        
 and Steven Boyd. Armistice Capital is the investment manager of Armistice Capital Master Fund Ltd. (the “Master Fund”),                
 the direct holder of the Shares, and pursuant to an Investment Management Agreement, Armistice Capital exercises voting and investment 
 power over the securities of the Company  held by the Master Fund and thus may be deemed to beneficially own the securities            
 of the Company held by the Master Fund. Mr. Boyd, as the managing member of Armistice Capital, may be deemed to beneficially own       
 the securities of the Company held by the Master Fund. The Master Fund specifically disclaims beneficial ownership of the securities   
 of the Company directly held by it by virtue of its inability to vote or dispose of such securities as a result of its Investment      
 Management Agreement with Armistice Capital. Does not include 1,826,000 pre-funded warrants held by Armistice Capital,                 
 which pre-funded warrants may be exercised from time to time and are subject to a 9.99% ownership limitation, and warrants to purchase 
 2,885,246 shares of common stock, which warrants remain subject to exercise and are subject to a maximum 9.99% ownership limitation.   |

| 31 |

Change of Control

The Company is not aware of any arrangements which may at a subsequent date result in a change of control of the Company.

Securities authorized for issuance under equity compensation plans

2018 Equity Incentive Plan

Our 2018 Equity Incentive Plan provides for equity incentives to be granted to our employees, executive officers or directors and to key advisers and consultants. Equity incentives may be in the form of stock options with an exercise price of not less