Company: RVRC
Filing Date: 2025-08-13
Form Type: S-1/A
Source: 0001213900-25-075747
Chunk: 115

Company: Revium Rx.
Filing Date: 2025-08-13
Form: S-1/A
Chunk 115
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. Mergers and acquisitions in the pharmaceutical
and biotechnology industries may result in even more resources being concentrated among a smaller number of our competitors. Smaller
or early-stage companies may also prove to be significant competitors, particularly through collaborative arrangements with large and
established companies. These competitors also compete with us in recruiting and retaining qualified scientific and management personnel
and establishing clinical trial sites and patient registration for clinical trials, as well as in acquiring technologies complementary
to, or necessary for, our programs. The current market for treatments that assist in novel therapeutics for major unmet medical needs,
is highly unknown. Our commercial opportunity would be reduced significantly if our competitors develop and commercialize products that
are safer, more effective, more convenient, have fewer side effects or are less expensive than our product candidates.

Competition related to Nano Mupirocin

The global challenge of antibiotic resistance
has prompted a surge in the development of innovative therapeutic solutions, positioning our Nano-Mupirocin product candidate in a competitive
landscape that includes a diverse array of pharmaceutical companies, biotechnology firms, and academic institutions. These entities are
engaged in the discovery and development of novel antibiotics, antibiotic combination therapies, bacteriophage therapies, antimicrobial
peptides, and other non-traditional antibacterial strategies aimed at overcoming or circumventing resistance mechanisms. Nano-Mupirocin
product candidate presents a novel approach to addressing the critical issue of antibiotic resistance by using a new mechanism of action
antibiotic for systemic infections and novel drug delivery system that enhances drug distribution and half-life in the blood.

Among our direct competitors are companies
advancing new chemical entities (NCEs) that exhibit novel mechanisms of action against resistant bacteria, including Spero Therapeutics
and Entasis Therapeutics, which are developing innovative classes of antibiotics designed to target gram-negative bacteria, including
those resistant to carbapenems and third-generation cephalosporins. These new antibiotics aim to address critical gaps in current treatment
options for multidrug-resistant infections. The US-based startup Acurx Pharmaceuticals offers Ibezapolstat, their lead antibiotic candidate,
for the treatment of clostridium difficile infections. This antibiotic blocks the Pol 3IIIC enzymes in streptococcal, staphylococcal,
and enterococcal infections. The antibiotic also inhibits further DNA replication of CDI-causing pathogen and is currently undergoing
Phase II trials. Dutch startup AGILeBiotics creates novel antibiotics for the treatment of