Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119822
Chunk: 0

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 0
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Filed Pursuant to Rule 424(b)(3)
Registration No. 333-280882 PROSPECTUS SCILEX HOLDING COMPANY Up to 3,593,288 Shares of Common Stock Up to 3,250,000 Shares of Common Stock offered by the Selling Securityholder This prospectus relates to the issuance by us of up to an aggregate of 3,593,288 shares of our Common Stock issuable as follows:

| (i) | 122,132 shares of Common Stock issuable upon exercise of the warrants to purchase shares of Common Stock issued                                                                                                                        
 in an underwritten offering consummated in March 2024, consisting of (a) 108,686 shares having an exercise price of $59.50 per share and (b) 13,446 shares having an exercise price of $74.38 per share ((a) and (b) collectively, the 
 “February 2024 BDO Warrants”);                                                                                                                                                                                                         |

| (ii) | 462,858 shares of Common Stock issuable upon exercise of the warrants to purchase shares of Common Stock issued                                                                                                                            
 in a registered direct offering consummated in April 2024, consisting of (a) 428,572 shares having an exercise price of $38.50 per share and (b) 34,286 shares having an exercise price of $43.75 per share ((a) and (b) collectively, the 
 “April 2024 RDO Warrants”);                                                                                                                                                                                                                |

| (iii) | 319,132 shares of Common Stock issuable upon exercise of the warrants to purchase shares of Common Stock issued                                                                                                            
 pursuant to a securities purchase agreement (the “Tranche B Securities Purchase Agreement”), dated as of October 7, 2024, having a current exercise price of $36.40 per share (collectively, the “October 2024 Warrants”); |

| (iv) | 914,823 shares of Common Stock issuable upon conversion of the senior convertible notes issued pursuant to the                            
 Tranche B Securities Purchase Agreement, having a current conversion price of $36.40 per share (collectively, the “Tranche B Notes”); and |

| (v) | 1,774,343 shares of Common Stock issuable upon exercise of the warrants to purchase shares of Common Stock                                                                                                                          
 issued in a registered direct offering consummated in December 2024 (the “December RDO”), consisting of (a) 1