Company: CNTB
Filing Date: 2025-09-10
Form Type: POS AM
Source: 0001193125-25-200186
Chunk: 60

Company: Connect Biopharma Holdings Ltd
Filing Date: 2025-09-10
Form: POS AM
Chunk 60
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, Cayman Islands.

Investing in our Ordinary Shares involves a high degree of risk. Before making an investment decision, please read the information under the heading “ Risk Factors” beginning on page 13 of this prospectus, and in the documents incorporated by reference into this prospectus.

None of the United States Securities and Exchange Commission, any state securities commission or any other regulatory body, has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

Cantor

The date of this prospectus is , 2025.

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS                                           |     |  1 |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS            |     |  2 |
| PROSPECTUS SUMMARY                                              |     |  3 |
| THE OFFERING                                                    |     | 12 |
| RISK FACTORS                                                    |     | 13 |
| USE OF PROCEEDS                                                 |     | 15 |
| CAPITALIZATION                                                  |     | 16 |
| DESCRIPTION OF SHARE CAPITAL                                    |     | 17 |
| MATERIAL TAX CONSIDERATIONS                                     |     | 27 |
| PLAN OF DISTRIBUTION                                            |     | 35 |
| ENFORCEMENT OF CIVIL LIABILITIES                                |     | 37 |
| LEGAL MATTERS                                                   |     | 38 |
| EXPERTS                                                         |     | 38 |
| WHERE YOU CAN FIND MORE INFORMATION; INCORPORATION BY REFERENCE |     | 39 |

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement that we filed on Form F-3 with the
SEC, under the Securities Act of 1933, as amended, or the Securities Act, using a “shelf” registration process. Under this prospectus, we may offer and sell up to $150,000,000 of our Ordinary Shares from time to time through Cantor
acting as our agent at prices and on terms to be determined by market conditions at the time of the offering.

This
prospectus relates to the offering of our Ordinary Shares. Before buying any of the Ordinary Shares that we are offering, we urge you to carefully read this prospectus, together with the information incorporated by reference as described under the
heading “Where You Can Find More Information; Incorporation by Reference.” These documents contain important information that you should consider when making your investment decision.

This prospectus describes the