Company: APM
Filing Date: 2025-01-03
Form Type: 424B5
Source: 0001213900-25-000606
Chunk: 12

Company: Aptorum Group Ltd
Filing Date: 2025-01-03
Form: 424B5
Chunk 12
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<div align='center'>S-5

RISK FACTORS</div>

Investing in our
securities involves a high degree of risk. You should carefully consider the risk factors set forth under “Risk Factors”
described in our most recent annual report on Form 20-F, filed on April 30, 2024, as supplemented and updated by subsequent current
reports on Form 6-K that we have filed with the SEC, and any applicable prospectus supplement and in any related free writing
prospectus in connection with a specific offering, before making an investment decision. Each of the risk factors could materially
and adversely affect our business, operating results, financial condition, and prospects, as well as the value of an investment in
our securities, and the occurrence of any of these risks might cause you to lose all or part of your investment.

In addition to the risk factors
referenced above, we want to disclose the additional risk factors below.

Risks Related to This Offering

We have broad discretion in the use of the net proceeds of this offering and may not use them effectively.

We intend to use the net proceeds
of this offering to restore and improve our research and development and for general operation purposes. We may also use a portion of
the net proceeds of this offering to acquire other products or businesses, although we are not currently a party to an agreement regarding
any such acquisition. However, our management will have broad discretion in the application of the net proceeds from this offering and
will have the right to use the net proceeds for purposes that differ substantially from our current plans. Management may spend the net
proceeds in ways that do not improve our results of operations or enhance the value of our Class A Ordinary Shares. The failure by management
to apply these funds effectively could result in financial losses that could have a material and adverse effect on our business and cause
the price of our Class A Ordinary Shares to decline.

<div align='center'>S-6</div>

If you purchase the Class A Ordinary Shares sold in this offering, you will experience immediate and substantial dilution in the net tangible book value of your shares.

The price per Class A Ordinary
Share being offered may be higher than the net tangible book value per share of our outstanding Class A Ordinary Shares prior to this
offering. An aggregate of 1,535,000 Class A Ordinary Shares are sold at a price of $2.00 per share, for aggregate gross proceeds of $3,070