Company: SFNC
Filing Date: 2025-09-10
Form Type: 424B5
Source: 0001193125-25-200113
Chunk: 28

Company: SIMMONS FIRST NATIONAL CORP
Filing Date: 2025-09-10
Form: 424B5
Chunk 28
---
, investors may suffer from increased pricing volatility and market risk.

The price at which the Notes may be sold prior to maturity will depend on a number of factors and may be substantially less than the amount for which they were originally purchased.

Some of these factors include, but are not limited to: (i) actual or anticipated changes in the level of Three-Month Term SOFR,
(ii) volatility of the level of Three-Month Term SOFR, (iii) changes in interest and yield rates, (iv) any actual or anticipated changes in our credit ratings or credit spreads and (v) the time remaining to maturity of such Notes.
Generally, the longer the time remaining to maturity and the more tailored the exposure, the more the market price of the Notes will be affected by the other factors described in the preceding sentence. This can lead to significant adverse changes
in the market price of securities like the Notes. Depending on the actual or anticipated level of Three-Month Term SOFR, the market value of the Notes may decrease and you may receive substantially less than 100% of the issue price if you are able
to sell your Notes prior to maturity.

The calculation agent will make determinations with respect to the Notes.

During each Floating Rate Interest Payment Period, the calculation agent will determine the interest rates with respect to the Notes using
Three-Month Term SOFR as further described in this prospectus supplement. In addition, if a Benchmark Transition Event and its related Benchmark Replacement Date have occurred, the calculation agent will make certain determinations with respect to
the Notes in the calculation agent’s sole discretion as further described under “Description of the Notes — Determinations and Decisions.” Any of these determinations may adversely affect the payout to investors. Moreover,
certain determinations made by us or our designee may require the exercise of discretion and the making of subjective judgments, such as with respect to the Benchmark rate or the occurrence or non-occurrence
of a Benchmark Transition Event and any Benchmark Replacement Conforming Changes. These potentially subjective determinations may adversely affect the payout to you on the Notes. For further information regarding these types of determinations, see
“Description of the Notes — Determinations and Decisions” and related definitions below.

S-18

USE OF PROCEEDS

We estimate that the net proceeds to us from this offering will be approximately $321.3 million, after deducting underwriting discounts and
commissions and the estimated offering expenses payable by us.

We intend to use the net proceeds, together with cash