Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 476

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 476
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4 Warrants”).

As of September 30, 2025, there were 1,013,122 December 2024 Warrants that remain outstanding. All of the December 2024 RDO Pre-Funded Warrants have been exercised.

The December 2024 RDO Common Warrants, subject to certain
ownership limitations, become exercisable on the six month anniversary of the date of issuance and one half of the December 2024 RDO Common Warrants have a term that expires five years from the date of issuance and the
remaining one-half of such December 2024 RDO Common Warrants have a term that expires two and one-half years from the date of issuance.

The StockBlock Warrants are exercisable on the six-month anniversary of the date of issuance and one
half of the StockBlock Warrants have a term that expires five years from the commencement of sales in the offering

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and the remaining one-half of such StockBlock Warrants have a term that expires on the date that is two
and one-half years from the date of issuance.

The exercise price of the December 2024
Warrants is subject to certain adjustments, including stock dividends, stock splits, combinations and reclassifications of the Common Stock. A holder (together with its affiliates) may not exercise any portion of the December 2024 Warrants to the
extent that the holder would own more than 4.99% (or, at the holder’s option upon issuance, 9.99%) of the outstanding shares of Common Stock immediately after exercise (the “December 2024 RDO Beneficial Ownership Limitation”).
However, upon at least 61 days’ prior notice from the holder to the Company, a holder may increase or decrease the December 2024 RDO Beneficial Ownership Limitation in accordance with the terms of the December 2024 RDO Warrant, provided that
it does not exceed 9.99%.

The foregoing summaries of the terms and conditions of the December 2024 Warrants do not purport to be complete
and are qualified in their entirety by reference to the copies of the forms of December 2024 Warrants that are filed as an exhibit to the registration statement of which this prospectus forms a part.

September 2025 Warrants

On
September 30, 2025, we entered into Warrant Exercise Agreements with the September 2025 Warrant Holders. Pursuant to the Warrant Exercise Agreement, the September 202