Company: APM
Filing Date: 2025-11-18
Form Type: DEL AM
Source: 0001213900-25-112134
Chunk: 0

Company: Aptorum Group Ltd
Filing Date: 2025-11-18
Form: DEL AM
Chunk 0
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<div align='center'>Aptorum Group Limited

17 Hanover Square

London W1S 1BN, United Kingdom

+ 44 20 80929299</div>

VIA EDGAR

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, DC 20549

November 18, 2025

| Re: | Aptorum Group Limited              
 Registration Statement on Form F-1 
 Filed on November 17, 2025         |
|:----|:-----------------------------------|
|     | File No. 333-291593                |

Ladies and Gentlemen:

Reference is made to the Registration Statement on
Form F-1 (File No. 333-291593) filed by Aptorum Group Limited on November 17, 2025 (the “Registration Statement”).

Pursuant to Rule 473(c) of the Securities
Act of 1933 (the “Act”), the following delaying amendment, prescribed by Rule 473(a) of the Act, is hereby incorporated
into the facing page of the Registration Statement:

“The registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until the Registration Statement shall become effective on such date as the Commission, acting pursuant to said Section 8(a), may determine.”

Should you have any questions regarding the Registration
Statement, please feel free to contact the undersigned at +4420 80929299.

| Sincerely, |                         |
| By:        | /s/ Ian                 
 Huen                    |
| Name:      | Ian Huen                |
| Title:     | Chief Executive Officer |

| cc: | Louis Taubman, Esq.             |
|     | Hunter Taubman Fischer & Li LLC |