Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 207

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 207
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 corporate infrastructure. As a result, we have concluded that there is substantial doubt about our ability to continue as a going concern within one year after the date that the consolidated financial statements are issued. See Note 2 titled “ Liquidity and Going Concern” to our consolidated financial statements included elsewhere in this prospectus for additional information. Our existing cash and cash equivalents may be insufficient to enable us to fund our operating expenses, capital expenditure requirements, and to service our debt obligations (whether under the Oramed Note, the Tranche B Notes or otherwise) for at least the next 12 months. If these sources are insufficient to satisfy our liquidity requirements, we may seek to raise additional funds through equity offerings, debt financings, collaborations, government contracts or other strategic transactions. Cash Flows The following table summarizes our cash flows for each of the periods presented (in thousands):

|                                                          |     | Year Ended   
 December 31, 
 2024         |         |   |     | 2023 |         |   |
|:---------------------------------------------------------|:----|:-------------|--------:|:--|:----|:-----|--------:|:--|
| Cash Flow Data:                                          |     |              |         |   |     |      |         |   |
| Net cash proceeds from (used for) operating activities   |     | $            |  19,349 |   |     | $    | (20,707 | ) |
| Net cash used for investing activities                   |     |              |  (2,675 | ) |     |      |    (330 | ) |
| Net cash (used for) proceeds from financing activities   |     |              | (18,131 | ) |     |      |  23,582 |   |
| Net change in cash, cash equivalents and restricted cash |     | $            |  (1,457 | ) |     | $    |   2,545 |   |

Cash Flows from Operating Activities For the year ended December 31, 2024, net cash proceeds from operating activities was approximately $19.3 million, attributable to non-cashreconciling items of $27.3 million related to allocated expense for financial instruments at fair value, stock-based compensation, change in fair value of debt and liability 130

instruments, allowances for expected credit losses, depreciation and amortization, non-cash operating lease cost and gain on derivative liabilities, and
changes in operating assets and liabilities that provided $64