Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063906
Chunk: 13

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 13
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. For example, in brain health, risk stratification may involve assessing factors such as miRNA profile, protein biomarker status, APOE genotype, and family history of AD to categorize patients into low, moderate, or high -riskgroups. This information guides decisions regarding treatment options, lifestyle modifications, and preventive measures for each risk category. •“SBIR” refers to Small Business Innovation Research, a funding program administered by the National Institutes of Health. •“Securities Exchange Commission,” “SEC,” “Commission” or similar terms refer to the Securities Exchange Commission. •“Sarbanes -OxleyAct” refers to the Sarbanes -OxleyAct of 2002. •“Scipio” refers to Scipio Life Sciences Limited, originally a consolidated VIE in which we indirectly hold 97.93% economic interest and 35.06% voting power, and Aptorum was regarded as the primary beneficiary of Scipio for accounting purposes. In November 2024, the Group acquired 10,000 Class A ordinary shares and 5,850,000 Class B ordinary shares of Scipio, achieving control over the entity. As a result of this acquisition, Scipio is no longer classified as a VIE under the Group and it became a subsidiary under the Group. •“Securities Act” refers to the Securities Act of 1933. •“UK” refers to the United Kingdom. •“United States,” “U.S.” and “US” refer to the United States of America. •“Videns” refers to Videns Incorporation Limited, a wholly -ownedsubsidiary of Aptorum Group. •“VIE” refers to a variable interest entity.

TABLE OF CONTENTS

|                                                                                                 |     | Page |
| TRADEMARKS, SERVICE MARKS AND TRADENAMES                                                        |     |   ii |
| QUESTIONS AND ANSWERS ABOUT THE MERGER                                                          |     |  iii |
| PROSPECTUS SUMMARY                                                                              |     |    1 |
| CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS                                       |     |   12 |
| RISK FACTORS                                                                                    |     |   14 |
| PROPOSAL NO. 1 — THE SHARE CONSOLIDATION PROPOSAL                                               |     |   85 |
| PROPOSAL NO. 2 — THE DOMESTICATION PROPOSAL                                                     |     |   89 |
| PROPOSAL NO. 3