Company: EDSA
Filing Date: 2025-09-09
Form Type: 424B5
Source: 0001171843-25-005799
Chunk: 37

Company: Edesa Biotech, Inc.
Filing Date: 2025-09-09
Form: 424B5
Chunk 37
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 Toronto, Ontario M5J 2Y1.

#### Canadian Securities Matters
The common shares are being distributed
pursuant to a prospectus exemption under applicable Canadian securities laws on the basis that the common shares are being distributed
outside Canada. Wainwright has agreed not to engage in any solicitation or sale of common shares to a person or company who is a resident
of Canada or a person or company in Canada.

| S-22 |

### LEGAL MATTERS
Certain legal matters relating to the
offering of common shares under this prospectus supplement will be passed upon for us by Fasken Martineau DuMoulin, LLP, Toronto, Ontario,
Canada with respect to matters of Canadian law and by Lowenstein Sandler LLP, New York, New York with respect to matters of U.S. law.
Blank Rome LLP, New York, New York, is acting as counsel for Wainwright in connection with certain legal matters relating to the common
shares offered by this prospectus supplement.

| S-23 |

### EXPERTS
The consolidated financial statements
incorporated into this prospectus supplement and the accompanying prospectus by reference to our Annual Report on Form 10-K for the financial
year ended September 30, 2024, have been so incorporated in reliance on the report of MNP LLP, independent auditors, given on the authority
of said firm as experts in auditing and accounting.

| S-24 |

### WHERE YOU CAN FIND MORE INFORMATION
We file annual, quarterly and current
reports, proxy statements and other information with the SEC. The materials we file with or furnish to the SEC are available to the public
on the SEC’s Internet website at www.sec.gov. Those filings are also available to the public on our corporate website at
www.edesabiotech.com. Information contained on our website is not a part of this prospectus supplement and the inclusion of our
website address in this prospectus supplement is an inactive textual reference only.

This prospectus supplement and the accompany
prospectus forms part of a registration statement that we filed with the SEC. The registration statement contains more information than
this prospectus supplement and the accompanying prospectus regarding us and our securities, including certain exhibits and schedules.
You can obtain a copy of the registration statement from the SEC at www.sec.gov.

We are also a “reporting issuer”
in the Canadian provinces of British Columbia and Alberta. As such, information we file with the SEC is also filed and publicly available