Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 222

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 222
---
, which were fully repaid
during the first quarter of 2024. The Oramed Note was issued in September 2023 in the principal amount of $101.9 million, of which the principal amount of $25.0 million remained outstanding as of December 31, 2024. The FSF Deposit was
received in June 2024 in the principal amount of $10.0 million and was satisfied in November 2024 by the delivery of the Additional Product to Endeavor. The Tranche B Notes were issued in October 2024 in the principal amount of
$50.0 million, of which the principal amount of $38.0 million remained outstanding as of December 31, 2024.

Interest Expense, Net

Interest expense, net for the years ended December 31, 2024 and 2023 was $2.0 million and $1.1 million,
respectively. The increase was attributed to $0.8 million of interest related to the Revolving Facility and $0.1 million of interest related to deferred consideration for GLOPERBA license acquired from Romeg in 2022.

148

Liquidity and Capital Resources As of September 30, 2025, we had cash and cash equivalents of approximately $0.9 million. We have indebtedness pursuant to the Oramed Note and Tranche B Notes as well as deferred consideration related to the GLOPERBA license acquired from Romeg in 2022. The following table summarizes the aggregate indebtedness of these issuances as of September 30, 2025, December 31, 2024, and December 31, 2023 (in thousands):

| Oramed Note (outstanding principal balance: $26.0 million, $25.0 million, and           
 $100.9 million as of September 30, 2025, December 31, 2024 and 2023, respectively)      |     | September 30, 
 2025          | 24,863 |     | December 31, 
 2024         | 12,161 |     | December 31, 
 2023         | 104,089 |
|:----------------------------------------------------------------------------------------|:----|:--------------|-------:|:----|:-------------|-------:|:----|:-------------|--------:|
| Convertible Debentures (outstanding principal balance: nil, nil, and $4.4 million as of 
 September