Company: SMNR
Filing Date: 2025-08-13
Form Type: 424B3
Source: 0001193125-25-179226
Chunk: 75

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-08-13
Form: 424B3
Chunk 75
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 to be presented at the Meeting is a non-discretionaryproposal. Accordingly, if you are a beneficial owner and you do not provide voting instructions to your broker, bank or other holder of record holding shares for you, your shares will not be voted with respect to any of the Proposals. Broker non-voteswill have no effect on the vote for the any of the Proposals.

| Q: | What if I abstain from voting or fail to instruct my bank, brokerage firm or nominee? |

| A: | Denali will count a properly executed proxy marked “ABSTAIN” with respect to a particular Proposal                                                                                              
 as present for the purposes of determining whether a quorum is present at the Meeting but it will not otherwise be counted. Broker non-votes will have no effect on the vote for the Proposals. |

| Q: | If I am not going to attend the Meeting, should I return my proxy card instead? |

| A: | Yes. Whether you plan to attend the Meeting or not, please read the enclosed proxy statement/prospectus                                                                                                          
 carefully, and vote your Denali Ordinary Shares by completing, signing, dating and returning the enclosed proxy card in the postage-paid envelope provided so as to be received no later than the time appointed 
 for the commencement of the Meeting.                                                                                                                                                                             |

31

| Q: | How can I submit a proxy? |

| A: | You may submit a proxy by (a) visiting the website listed on your proxy card and following the on screen                                                                                                                                                
 instructions (have your proxy card available when you access the webpage), or (b) if a telephone number is listed on your proxy card, by calling the telephone number listed on your proxy card, or (c) submitting your proxy card by mail by using the 
 previously provided self-addressed, stamped envelope.                                                                                                                                                                                                   |

| Q: | Can I change my vote after I have mailed my proxy card? |

| A: | Yes. If you are a shareholder of record of Denali Ordinary Shares as of the close of business on the Record 
 Date, you can change or revoke your proxy before it is voted at the Meeting in one of the following ways:   |

| • |     | Submit a new proxy card bearing a later date; or |

| • |     | Vote in person. Please note that your attendance at the extraordinary general meeting will not alone serve to 
 revoke your proxy.                                                                                            |

| Q: | What will happen if I return my proxy card without indicating how to