Company: PFSA
Filing Date: 2025-10-29
Form Type: 424B3
Source: 0001213900-25-103174
Chunk: 45

Company: Profusa, Inc.
Filing Date: 2025-10-29
Form: 424B3
Chunk 45
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and expenses, including legal fees, and could result in a material adverse effect on our business, prospects, financial condition, or
results of operations. We could also incur severe penalties, including criminal and civil penalties, disgorgement, and other remedial
measures.

Unfavorable global economic conditions could adversely affect our business, financial condition or results of operations.

Our results of operations could
be adversely affected by general conditions in the global economy and in the global financial markets, including changes in inflation,
interest rates and overall economic conditions and uncertainties. To the extent inflation or other factors increase our business costs,
it may not be feasible to pass price increases on to our customers or offset higher costs through manufacturing efficiencies. Inflation
could also adversely affect the ability of our customers to purchase our products. An economic downturn could result in a variety of risks
to our business, including weakened demand for our products and our inability to raise additional capital when needed on acceptable terms,
if at all. A weak or declining economy could also result in further constraints on our suppliers or cause future customers to delay making
payments for our products. Any of the foregoing could harm our business and we cannot anticipate all of the ways in which the current
economic climate and financial market conditions could adversely impact our business.

We may experience pricing pressures from contract suppliers or manufacturers on which we rely.

We expect that there will be
supply constraints and our suppliers may continue to raise prices, which we may not be able to offset through manufacturing efficiencies
or pricing actions. Pricing pressures from third parties could increase our costs and force us to increase the prices of our products
if we are unable to enter into alternative arrangements with other suppliers or manufacturers, potentially leading to decreased customer
demand.

Manufacturing difficulties and/or any disruption at our facilities may adversely affect our manufacturing operations and related product sales, and increase our expenses.

Our products are manufactured
at two facilities located in California, with limited alternate facilities. If an event occurs at one of our facilities that results in
damage to, or closure of, one or more of such facilities, or if our distributions from those facilities are limited or restricted in any
way, we may be unable to manufacture the relevant products at the previous levels or at all. Because of the time required to approve and
lease a manufacturing facility, an alternate facility and/or a third-party may not be available on a timely basis to replace production
capacity in the event manufacturing capacity is lost.

We take precautions to safeguard
our facilities, which include manufacturing protocols