Company: MDCXW
Filing Date: 2025-11-19
Form Type: S-1
Source: 0001062993-25-016962
Chunk: 112

Company: Medicus Pharma Ltd.
Filing Date: 2025-11-19
Form: S-1
Chunk 112
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'>Figure 2. Manufacturing flow chart</div>

Manufacturing Process Equipment

The equipment used to fabricate the arrays is listed in the table below:

Equipment Used to Fabricate Arrays

| Description            |     | Supplier     |     | Model/Part Number/Print                           |
| Centrifuge             |     | Thermofisher |     | Sorvall Lynx 4000                                 |
| Rotor                  |     | Thermofisher |     | BioFlex HC (PN 75003000Q502807)                   |
| Rotor Bucket           |     | Thermofisher |     | BioFlex HC (PN 75003000Q502807)                   |
| Bucket Lid with Gasket |     | Thermofisher |     | BioFlex HC Lid (PN 75007309Q502807)               |
| Bucket Insert          |     | GFE LLC      |     | GFE Print "Lynx Square Tool Holder Rev R1"        |
| Casting Mask           |     | GFE LLC      |     | GFE Print "Array Rev X6 Production Mold Frame"    |
| Casting Sleeve         |     | GFE LLC      |     | GFE Print "Array Rev X6 MNA Master Sleeve Rev E0" |
| Production Mold        |     | GFE LLC      |     | GFE Print "Array Rev X6 Production Mold Rev E0"   |

<div align='center'>73</div>

In an initial step, a master mold is fabricated by a milling process under CAD/CAM of a suitable material such as an acrylic or a metal alloy, rendering the required geometry for the microneedles. Once fabricated, the master mold is stored for future rendering of production molds as needed. The masters are wrapped in a clean-room towel for protection and stored in individually labeled rigid containers. The production molds are stored 4 per glass container labeled with revision codes. All materials are stored in a final secondary container labeled masters and production molds.

The master mold is then used to fabricate the production molds from polydimethyl siloxane (PDMS; (Slygard® 184, Dow Corning) (B)). This latter material is poured onto the master mold, positioned, and spun in the same centrifuge used to fabricate the arrays such that the forces and angles used to make the production mold mirror those used to fabricate, ultimately, the arrays. The production molds are inspected after every production cycle to ensure integrity of the needle forms. Protocol P171