Company: XXII
Filing Date: 2025-06-20
Form Type: S-3
Source: 0001641172-25-015905
Chunk: 0

Company: 22nd Century Group, Inc.
Filing Date: 2025-06-20
Form: S-3
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on June 20, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-3

REGISTRATION STATEMENT UNDER

THE SECURITIES ACT OF 1933

22nd CENTURY GROUP, INC.

(Exact name of registrant as specified in its charter)</div>

| Nevada                            |     | 98-0468420         |
| (State                            
 or other jurisdiction             
 of incorporation or organization) |     | -I.R.S. Employer   
 Identification No. |

<div align='center'>321 Farmington Rd

Mocksville, NC 27028

(336) 940-3769

(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

Daniel A. Otto

Chief Financial Officer

22nd Century Group, Inc.

321 Farmington Rd

Mocksville, NC 27028

(336) 940-3769

(Name, address, including zip code, and telephone number, including area code, of agent for service)

with a copy to:</div>

| John                          
 J. Wolfel, Esq.               |     | Jonathan            
 Staffeldt           |
| Foley                         
 & Lardner LLP                 |     | General             
 Counsel             |
| One                           
 Independent Drive, Suite 1300 |     | 22nd                
 Century Group, Inc. |
| Jacksonville,                 
 Florida 32202                 |     | 321                 
 Farmington Rd       |
| (904)                         
 359-2000                      |     | Mocksville,         
 NC 27028            |
|                               |     | (336)               
 940-3769            |

Approximate date of commencement of proposed sale to the public:From time to time after this registration statement becomes effective.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, please check the following box. ☒

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act