Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 110

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 110
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 contained in the documents incorporated by reference herein. We will provide you without charge, upon your written or oral request, a copy of any of the documents incorporated by reference in this prospectus, other than exhibits to such documents which are not specifically incorporated by reference into such documents. Please direct your written or telephone requests to NuCana plc, 3 Lochside Way, Edinburgh, EH12 9DT, United Kingdom. Our telephone number is +44 (0)131 357 111. You may also obtain information about us by visiting our website at https://www.nucana.com/. Except for the specific incorporated documents listed above, no information available on or through our website shall be deemed to be incorporated in this prospectus or the registration statement of which it forms a part. The SEC also maintains an internet site that contains reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC (http://www.sec.gov). 74

Up to 12,497,768 American Depositary Shares Representing

312,444,200 Ordinary Shares

Series A Warrants to Purchase up to 12,497,768 American Depositary Shares Representing up to 312,444,200 Ordinary Shares

Series B Warrants to Purchase up to 12,497,768 American Depositary Shares Representing up to 312,444,200 Ordinary Shares

Pre-FundedWarrants to Purchase up to 12,497,768 American Depositary Shares Representing up to 312,444,200 Ordinary Shares

Up to 559,275,129 American Depositary Shares Underlying the Series A Warrants, the Series B Warrants (which Series B Warrants contain a “zero exercise price” option) and the Pre-Funded Warrants Representing up to 13,981,878,225 Ordinary Shares

PRELIMINARY PROSPECTUS

, 2025

LAIDLAW & COMPANY (UK) LTD.

Part II INFORMATION NOT REQUIRED IN THE PROSPECTUS

| Item 6. | Indemnification of directors and officers |

Members of our board of directors and its officers have the benefit of the following indemnification provisions in our articles of association: Subject always to the provisions of the statutes of the United Kingdom and any other statutes that concern and affect us as a company, or collectively, the Statutes, we may, at our discretion and subject to any policies adopted by the board of directors, indemnify any current and former members of our board of