Company: DMAC
Filing Date: 2025-08-12
Form Type: S-3
Source: 0001437749-25-026273
Chunk: 3

Company: DiaMedica Therapeutics Inc.
Filing Date: 2025-08-12
Form: S-3
Chunk 3
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 supplement.

We may from time to time offer and sell our securities in one offering or in separate offerings, to or through underwriters, dealers and agents or directly to purchasers. If any agents or underwriters are involved in the sale of any of these securities, the applicable prospectus supplement will provide the names of the agents or underwriters and any applicable fees, commissions or discounts.

Our common shares are listed on The Nasdaq Capital Market under the symbol “DMAC.” On August 11, 2025, the last reported sale price of our common shares as reported on The Nasdaq Capital Market was $4.58 per share.

Investing in our securities involves risks. You should consider carefully the risks and uncertainties set forth in the section entitled“Risk Factors”beginning on page 5 of this prospectus, in any related prospectus supplement, and in the documents that are incorporated by reference in this prospectus before making a decision to purchase our securities.

NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

<div align='center'>The date of this prospectus is , 2025.

TABLE OF CONTENTS</div>

Page

| ABOUT THIS PROSPECTUS                                |  1 |
| ABOUT DIAMEDICA THERAPEUTICS INC.                    |  2 |
| RISK FACTORS                                         |  5 |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS |  6 |
| USE OF PROCEEDS                                      |  8 |
| DESCRIPTION OF COMMON SHARES                         |  9 |
| DESCRIPTION OF WARRANTS                              | 20 |
| DESCRIPTION OF UNITS                                 | 22 |
| PLAN OF DISTRIBUTION                                 | 23 |
| LEGAL MATTERS                                        | 25 |
| EXPERTS                                              | 26 |
| WHERE YOU CAN FIND MORE INFORMATION                  | 27 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE    | 28 |

<div align='center'>ABOUT THIS PROSPECTUS</div>

This prospectus is part of a registration statement that we filed with the United States Securities and Exchange Commission (SEC) utilizing a “shelf” registration process. Under this shelf registration process, we may offer and sell any combination of the securities described in this prospectus