Company: SCLXW
Filing Date: 2025-12-01
Form Type: 424B3
Source: 0001193125-25-303054
Chunk: 2

Company: Scilex Holding Co
Filing Date: 2025-12-01
Form: 424B3
Chunk 2
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 (Exact name of registrant as specified in its charter)

| Delaware                     |     | 001-39852   |     | 92-1062542         |
| (State or other jurisdiction 
 of incorporation)            |     | -Commission 
 File Number |     | -IRS Employer      
 Identification No. |

960 San Antonio Road, Palo Alto, California, 94303 (Address of principal executive offices, including zip code) Registrant’s telephone number, including area code: (650) 516-4310 N/A (Former name or former address, if changed since last report) Check the appropriate box below if the Form 8-Kfiling is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

| ☐ | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |

| ☐ | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 
 CFR 240.14a-12)                                                        |

| ☐ | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |

| ☐ | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |

Securities registered pursuant to Section 12(b) of the Act

| Title of each class                                                         |     | Trading   
 Symbol(s) |     | Name of each exchange       
 on which registered         |
| Common stock, par value $0.0001 per share                                   |     | SCLX      |     | The Nasdaq Stock Market LLC |
| Warrants to purchase common stock at an exercise price of $402.50 per share |     | SCLXW     |     | The Nasdaq Stock Market LLC |

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2of the Securities Exchange Act of 1934 (§240.12b-2of this chapter). Emerging growth company ☒ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☒

| Item