Company: APM
Filing Date: 2025-10-14
Form Type: 424B5
Source: 0001213900-25-098635
Chunk: 66

Company: Aptorum Group Ltd
Filing Date: 2025-10-14
Form: 424B5
Chunk 66
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emptions under applicable state laws. Accordingly, the investors may exercise the warrants and sell the underlying ordinary shares only
pursuant to an effective registration statement under the Securities Act covering the resale of those shares, an exemption under Rule
144 under the Securities Act, or another applicable exemption under the Securities Act.

<div align='center'>S-37

PLAN OF DISTRIBUTION</div>

H.C. Wainwright & Co.,
LLC has agreed to act as the exclusive Placement Agent in connection with this offering subject to the terms and conditions of the engagement
letter, dated July 16, 2025. The Placement Agent is not purchasing or selling any securities offered by this prospectus supplement, nor
is the Placement Agent required to arrange the purchase or sale of any specific number or dollar amount of our securities but has agreed
to use its best efforts to arrange for the sale of our securities. Therefore, we may not sell all of securities being offered. The
Placement Agent will have no authority to bind us by virtue of the engagement letter. We have entered into a securities purchase agreement
directly with the institutional investors who have agreed to purchase securities in this offering. We will only sell securities in this
offering to investors who have entered into securities purchase agreements. The terms of this offering were subject to market conditions
and negotiations between us, the Placement Agent, and prospective investors. The factors considered in determining the price of the Class
A Ordinary Shares included the recent market price of our Class A Ordinary Shares, the general condition of the securities market at the
time of this offering, the history of, and the prospects, for the industry in which we compete, our past and present operations, and our
prospects for future revenues.

We expect that delivery of
the Class A Ordinary Shares being offered pursuant to this prospectus supplement and the accompanying prospectus will be made on or about
October 14, 2025, subject to customary closing conditions.

Fees and Expenses

The table below reflects the
total offering proceeds, before deducting the estimated offering expenses.

|                                  |     | Per              
 Class A Ordinary 
 Share            |      |     | Total |           |
| Offering price                   |     | US$              | 2.00 |     | US$   | 2,000,000 |
| Placement Agent’s Fees           |     | US$              | 0.14 |     | US$   |   140,000 |
| Proceeds to us (before expenses)