Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119822
Chunk: 401

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 401
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. The following table assumes that the Selling Securityholder will sell all of the Resale Shares listed in this prospectus. Except as indicated by the footnotes below, we believe, based on the information furnished to us, that the Selling Securityholder has sole voting and investment power with respect to all shares of Common Stock that such Selling Securityholder beneficially owns, subject to applicable community property laws. Except as otherwise described below, based on the information provided to us by the Selling Securityholder, the Selling Securityholder is not a broker-dealer or an affiliates of broker-dealers.

|                                |     | Number of Shares of 
 Common              
 Stock Beneficially  
 Owned               |         |     |         |      |   |     | Maximum     
 Number of   
 Shares of   
 Common      
 Stock Being 
 Offered(2)  |         |     | Shares of Common   
 Stock              
 Beneficially Owned 
 After the Offered  
 Shares of Common   
 Stock Are Sold     |   |     |   |
| Name of Selling Securityholder |     | Number(1)           |         |     | Percent |      |   |     | Number(2)   |         |     | Percent            |   |     |   |
| FSF 33433 LLC(3)               |     |                     | 365,107 |     |         | 4.99 | % |     |             | 365,107 |     |                    | — |     | * |

| * | Less than 1% |

| (1) | Beneficial ownership is determined in accordance with                                                                                                                                                                                                
 Rule 13d-3 under the Exchange Act. In computing the number of shares beneficially owned by a person and the percentage ownership of that person, shares of Common Stock subject to warrants, options                                                 
 and other convertible securities held by that person that are currently exercisable or exercisable (within 60 days of March 31, 2025) are deemed outstanding. Shares subject to warrants, options and other convertible securities, however, are not 
 deemed outstanding for the purpose of computing the percentage ownership of any other person.                                                                                                                                                        |

| (2) | Assumes that the Selling Securityholder disposes of all of the Resale Shares covered by this prospectus and                                                                                                                                   
 does not acquire beneficial ownership of any additional shares. The registration of the Resale Shares does not necessarily mean that the Selling Securityholder will sell all or any portion of the Resale Shares covered by this prospectus. |

256

| (