Company: CRL
Filing Date: 2025-02-19
Form Type: 10-K
Source: 0001100682-25-000011
Chunk: 37

Company: CHARLES RIVER LABORATORIES INTERNATIONAL, INC.
Filing Date: 2025-02-19
Form: 10-K
Item: Item 1A
Chunk 37
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 of our product and service offerings, including our non-human primate supply, are dependent on a limited source of supply that, when interrupted, adversely affects our business.

•Demand volatility, risk of credit losses, or a reduction or delay in government funding of R&D may adversely affect our business.

•Changes in government regulation or in practices relating to the pharmaceutical or biotechnology industries, including potential healthcare reform, could decrease the need for the services we provide.

•Contract development and manufacturing services create a risk of liability, including risk that our products will not gain market acceptance and risk of failure to provide quality and timely service to customers.

•Contaminations in our animal populations can damage our inventory, harm our reputation for contaminant-free production, result in decreased sales and cause us to incur additional costs.

•The outsourcing trend in non-clinical and clinical stages of drug discovery and development may decrease, which could impair our growth.

•The industries in which we operate are highly competitive.

•New technologies may be developed, validated and increasingly used in biomedical research, which could reduce demand for some of our products and services.

•We may not be able to successfully develop and market new services and products.

•Costs increasing more rapidly than market prices could reduce profitability.

Legal and Regulatory Risk Factors

•Any failure by us to comply with applicable regulations and related guidance could harm our reputation and operating results, and compliance with new regulations and guidance may result in additional costs.

•Failure to comply with applicable data privacy and security laws in various jurisdictions could subject us to denial of the right to conduct business, fines, criminal penalties and/or other enforcement actions that could have a material adverse effect on our business. 

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CHARLES RIVER LABORATORIES INTERNATIONAL, INC.

•Failure to comply with U.S., state, local or international environmental, health, safety and sustainability laws and regulations could result in fines and penalties and loss of licensure and have a material adverse effect upon the Company’s business.

•Changes in U.S. and International Tax Law, results of tax audits, or material changes in our stock price could have a material adverse impact on our effective tax rate and financial results.

•Non-clinical and clinical contract research services create a risk of liability.

•The failure to successfully obtain, maintain and enforce intellectual property rights and defend against assertions of third parties to intellectual property rights could adversely affect us.

•Our by-laws designate the state courts located in the State of Delaware as the sole and exclusive forum for certain actions, which could limit