Company: DRTSW
Filing Date: 2025-03-12
Form Type: 20-F
Source: 0001213900-25-023187
Chunk: 115

Company: Alpha Tau Medical Ltd.
Filing Date: 2025-03-12
Form: 20-F
Item: Item 4
Chunk 115
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 manufacture our Alpha DaRTs, and a          
  second facility located in the United States, in Lawrence, Massachusetts, which is currently focused on acquiring Thorium-228 and preparing    
  generators for use in Jerusalem in preparing Alpha DaRT treatments. We are constructing our first commercial-scale manufacturing facility      
  in Hudson, New Hampshire, and we expect the first phase to be ready for production by the end of 2025. We are exploring potential development  
  of an additional manufacturing facility and headquarters on a plot of land in the Har Hotzvim Industrial Park in Jerusalem, for which          
  we were awarded a discounted long-term leasehold by the Israel Land Authority.                                                                 
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  Pursue marketing authorization                                                                                                             

Background of Radiation-Based Cancer Treatment

Solid tumors

Tumors develop as an accumulation
of mutated cells that are unable to regulate their growth, moving through the cell cycle uncontrollably and dividing excessively with
properties that enable them to invade and destroy surrounding tissue. Cancer cells are able to co-opt the microenvironment, which enables
the tumors to bypass the immune system and promote further growth and spread. Cancer cells can break away from the original tumor via
the blood stream or the lymphatic system to form new cells elsewhere, called metastasis, and cause the growth of new blood vessels,
a process called angiogenesis, which gives tumor cells a source of oxygen, nutrients and a mechanism to release waste products.
In 2022 alone, there were approximately 20 million new cancer diagnoses and approximately 10 million cancer-related deaths worldwide,
of which over 90% related to solid tumors, according to the World Health Organization’s International Agency for Research on Cancer.

Radioactive decay

Radioactive decay, the process
by which a source emits energy that can penetrate certain materials, is well known for its extreme potency and capacity to destroy living
cells when the radiation generated is at a sufficiently high intensity. Such sources include elements that possess an excess or imbalance
of energy and consequently lack internal stability. As a result, such elements, termed radionuclides or radioisotopes, will naturally
and spontaneously emit, or radiate, the excess energy in order to stabilize, in a random process which cannot be predicted. However,
it is possible to define certain parameters such as the nature of the decay and its likelihood over a specified period of time. Amid the
process of radioactive decay, the original element, with