Company: SMNR
Filing Date: 2025-08-12
Form Type: S-4/A
Source: 0001193125-25-178821
Chunk: 969

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-08-12
Form: S-4/A
Chunk 969
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ISITION CORP. |     |                                 |
| By:                              |     | /s/ Lei Huang                   |
|                                  |     | Name: Lei Huang                 |
|                                  |     | Title:  Chief Executive Officer |
| DENALI MERGER SUB INC.           |     |                                 |
| By:                              |     | /s/ Peter Xu                    |
|                                  |     | Name: Peter Xu                  |
|                                  |     | Title:  President               |
| SEMNUR PHARMACEUTICALS, INC.     |     |                                 |
| By:                              |     | /s/ Jaisim Shah                 |
|                                  |     | Name: Jaisim Shah               |
|                                  |     | Title:  Chief Executive Officer |

A-2-5

**Annex A-3**

<div align='center'>**AMENDMENT NO. 2 TO AGREEMENT AND PLAN OF MERGER**</div>

THIS AMENDMENT NO. 2 TO AGREEMENT AND PLAN OF MERGER (this “Amendment”), dated as of July 22, 2025, is made and entered into by and among Denali Capital Acquisition Corp., a Cayman Islands exempted company (which shall migrate to and domesticate as a Delaware corporation prior to the Closing, “Parent”), Denali Merger Sub Inc., a Delaware corporation and wholly owned subsidiary of Parent (the “Merger Sub” and together with Parent, collectively, the “Parent Parties”), and Semnur Pharmaceuticals, Inc., a Delaware corporation (the “Company”).

WHEREAS, the Parent Parties and the Company have entered into an Agreement and Plan of Merger, dated as of August 30, 2024 (as amended, restated, supplemented or otherwise modified from time to time, including pursuant to that certain Amendment No.1, dated as of April 16, 2025, the “Merger Agreement”), providing for, among other things, the merger of Merger Sub with and into the Company, with the Company continuing as the Surviving Corporation;

WHEREAS, prior to the completion of the transactions contemplated by the Merger Agreement, (i) Parent and the Company may enter into one or more securities purchase agreements or similar agreements with certain investors to be named therein (the “Semnur Investors”), pursuant to which, among other things, the Semnur Investors may purchase Company Common Shares in an amount and at a purchase price, in each case,