Company: LENZ
Filing Date: 2025-04-14
Form Type: 424B3
Source: 0001628280-25-017694
Chunk: 15

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-14
Form: 424B3
Chunk 15
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 the number of shares registered

<div align='center'>10</div>

on its behalf. A selling securityholder may sell or otherwise transfer all, some or none of such shares in this offering. See “ Plan of Distribution .”

| Name of Selling Securityholder                          |     | Common       
 Stock        
 Beneficially 
 Owned        
 Prior to     
 Offering     |            |     |        |     | Number of 
 Shares of 
 Common    
 Stock     
 Being     
 Offered   |            |     |         |     | Common Stock    
 Beneficially    
 Owned After the 
 Offered Shares  
 of              
 Common Stock    
 are Sold        |        |     |   |   |   |
|                                                         |     |              |            |     | Number |     |           |            |     | Percent |     |                 |        |     |   |   |   |
| Alpha Wave Ventures II, LP(1)                           |     |              |  3,612,211 |     |        |     |           |  3,612,211 |     |         |     |                 |      — |     |   | — |   |
| McCollum Living Trust(2)                                |     |              |    636,924 |     |        |     |           |    595,842 |     |         |     |                 | 41,082 |     |   |   | * |
| Entities affiliated with RA Capital Management, L.P.(3) |     |              |  4,259,106 |     |        |     |           |  4,249,356 |     |         |     |                 |  9,750 |     | * |   |   |
| Entities affiliated with Versant Management(4)          |     |              |  4,612,684 |     |        |     |           |  4,612,684 |     |         |     |                 |      — |     |   | — |   |
| Total Shares                                            |     |              | 13,120,925 |     |        |     |           | 13,070,093 |     |         |     |                 | 50,832 |     |   |   |   |

__________________

* Less than 1%.

(1) Consists of (i) 2,714,002 shares of Common Stock received by Alpha Wave Ventures II, LP in the Merger as an equityholder of record of