Company: GHRS
Filing Date: 2025-02-27
Form Type: S-8
Source: 0001140361-25-006179
Chunk: 0

Company: GH Research PLC
Filing Date: 2025-02-27
Form: S-8
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As filed with the Securities and Exchange Commission on February 27, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GH Research PLC (Exact Name of Registrant as specified in its charter)

| Ireland                         | N/A                |
| (State or other jurisdiction of 
 incorporation or organization)  | -I.R.S. Employer   
 Identification No. |

|                                                                                                          | GH Research PLCJoshua Dawson HouseDawson StreetDublin 2D02 RY95IrelandTel: +353 1 437 8334 |
| (Address, including zip code, and telephone number, including area code, of Principal Executive Offices) |                                                                                            |

| GH Research PLC Share Option Plan |                         |
|                                   | -Full title of the plan |

| Cogency Global Inc.122 East 42ndStreet, 18thFloorNew York, NY 10168Tel: (800) 221-0102               |
| (Name, address, including zip code, and telephone number, including area code, of agent for service) |

| Copies to:                |
| Adam Kaminsky             
 Davis Polk & Wardwell LLP 
 450 Lexington Avenue      
 New York, NY 10017        
 (212) 450-4000            |

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer☐                                            | Accelerated filer☒         |
| Non-accelerated filer☐(Do not check if a smaller reporting company) | Smaller reporting company☐ |

Emerging Growth Company ☒ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐ PART I REGISTRATION OF ADDITIONAL SECURITIES PURSUANT TO GENERAL INSTRUCTION Pursuant to General Instruction E to Form S-8, GH Research PLC (the “Registr