Company: SXTPW
Filing Date: 2025-02-06
Form Type: 424B5
Source: 0001213900-25-010772
Chunk: 54

Company: 60 DEGREES PHARMACEUTICALS, INC.
Filing Date: 2025-02-06
Form: 424B5
Chunk 54
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 the complications of Lyme disease. There may be more than       
 400,000 such tick bites in the United States requiring medical treatment each year. This estimate is based on the observation that         
 approximately 50,000 tick bites are treated in U.S. hospital emergency rooms each year; however, this calculation represents only          
 about 12% of actual treated tick bites based on observations from comparable ex-U.S health systems.14 Unlike Lyme disease,                 
 there is no characteristic rash associated with early infection and no reliable diagnostic tests. Thus, an individual bitten by a          
 tick cannot know whether they have also been infected with babesiosis. It is likely that a drug proven to be effective for this indication 
 for babesiosis would also be used in conjunction with Lyme prophylaxis.                                                                    |

Treatment and Prevention of Fungal Infections We are evaluating Tafenoquine for potential utility in the following fungal diseases:

| ● | Treatment                                                                                  
 of Candida infections. According to the CDC, there are 50,000 reported                     
 cases of candidiasis (a type of fungal infection) each year in the United States and up to 
 1,900 clinical cases of C. auris, for which there are few available treatments.15          
 Since it has broad-spectrum activity against drug-resistant Candida spp in culture,        
 Tafenoquine, has the potential to be a market leading therapy for treatment/prevention of  
 C. auris, and to be added to the standard of care regimens for other Candida infections.16 |

| 10 | This                                                                                               
 estimate is based on the observations of Krugeler et al (Emerg Infect Dis 2021;27:616-61)          
 who reported that 476,000 cases of Lyme disease occur in U.S. states where babesiosis is           
 endemic and Krause et. al. (JAMA 1996;275:1657-16602) who reported that 10% of Lyme disease        
 patients are co-infected with babesiosis and that according to Krause et al (AJTMH 2003;6:431-436) 
 fact that about 80% of cases are symptomatic (thus 476,000*10%*80% = 38,000 cases of babesiosis    
 per year).                                                                                         |

| 11 | Bloch                                           
 et al Open Forum Infect Dis 2022;9(11):ofac597. |

| 12 | According           
 to IDSA guidelines. |

| 13