Company: NCNA
Filing Date: 2025-04-24
Form Type: F-1
Source: 0001193125-25-092131
Chunk: 9

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-1
Chunk 9
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 the registration statement of which this prospectus is a part, and you may obtain copies of those documents as described below under “Where You Can Find More
Information.”

We have not, and the Placement Agent has not, authorized anyone to provide any information or to make any
representations other than those contained in this prospectus or in any free writing prospectuses, as well as the documents incorporated by reference into this prospectus or any prospectus supplement or any free writing prospectuses, prepared by or
on behalf of us or to which we have referred you. We take no responsibility for, and can provide no assurance as to the reliability of, any other information that others may give you. The information contained in this prospectus or any document
incorporated by reference or contained in any applicable free writing prospectus is current only as of its date, regardless of its time of delivery or any sale of our securities. Our business, financial condition, results of operations and prospects
may have changed since that date.

This prospectus does not constitute an offer to sell or the solicitation of an offer to buy any of our
securities other than the securities covered hereby, nor does this prospectus constitute an offer to sell or the solicitation of an offer to buy any securities in any jurisdiction to any person to whom it is unlawful to make such offer or
solicitation in such jurisdiction. Persons who come into possession of this prospectus in jurisdictions outside the United States are required to inform themselves about, and to observe, any restrictions as to the offering and the distribution of
this prospectus applicable to those jurisdictions.

Unless otherwise indicated or the context otherwise requires, in this prospectus,
“NuCana,” “NuCana plc,” the “Company,” “we,” “us” and “our” refer to NuCana plc and its consolidated subsidiaries. See “Description of Share Capital.”

This prospectus and the information incorporated by reference herein and therein contains references to trademarks, trade names and service
marks belonging to us or other entities. Solely for convenience, trademarks, trade names and service marks referred to in this prospectus may appear without the or TM symbols, but such
references are not intended to indicate, in any way, that the applicable owner will not assert, to the fullest extent under applicable law, its rights to these trademarks and trade names. We do not intend our use or display of other companies’
trade names, trademarks, or service marks to imply a relationship with, or endorsement or sponsorship of us by