Company: TVRD
Filing Date: 2025-10-20
Form Type: S-8
Source: 0001104659-25-100898
Chunk: 2

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-10-20
Form: S-8
Chunk 2
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The Registrant hereby incorporates by reference into this Registration
Statement the following documents previously filed by the Registrant with the Securities and Exchange Commission (“SEC”):

All documents, reports and definitive proxy or information statements
filed pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this Registration Statement and prior
to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all
securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof
from the date of filing of such documents; provided, however, that documents, reports and definitive proxy or information statements,
or portions thereof, which are furnished and not filed in accordance with the rules of the SEC shall not be deemed incorporated by
reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated herein by
reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement herein
or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes that
statement. Any such statement so modified or superseded shall not constitute a part of this Registration Statement, except as so modified
or superseded.

| ITEM 4. | DESCRIPTION OF SECURITIES. |

Not applicable.

| ITEM 5. | INTERESTS OF NAMED EXPERTS AND COUNSEL. |

Not applicable.

| ITEM 6. | INDEMNIFICATION OF DIRECTORS AND OFFICERS. |

Our amended and restated certificate of incorporation, as amended (the
“Charter”) limits the liability of directors to the maximum extent permitted by Delaware law. Delaware law provides that directors
of a corporation will not be personally liable for monetary damages for breach of their fiduciary duties as directors, except for liability
for any:

| · | breach of their duty of loyalty to the corporation or our stockholders; |

| · | act or omission not in good faith or that involves intentional misconduct 
 or a knowing violation of law;                                            |

| · | unlawful payments of dividends or unlawful stock repurchases or redemptions         
 as provided in Section 174 of the Delaware General Corporation Law (the “DGCL”); or |

| · | transaction from which the directors derived an improper personal benefit. |

Our Charter does not eliminate a director’s duty of care and,
in