Company: SCLXW
Filing Date: 2025-05-15
Form Type: 424B3
Source: 0000950170-25-071920
Chunk: 1

Company: Scilex Holding Co
Filing Date: 2025-05-15
Form: 424B3
Chunk 1
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 Agreement”), dated as of October 7, 2024, having a current exercise price of $36.40 per share (collectively, the “October 2024 Warrants”);

914,823 shares of Common Stock issuable upon conversion of the senior convertible notes issued pursuant to the Tranche B Securities Purchase Agreement, having a current conversion price of $36.40 per share (collectively, the “Tranche B Notes”); and

1,774,343 shares of Common Stock issuable upon exercise of the warrants to purchase shares of Common Stock issued in a registered direct offering consummated in December 2024 (the “December RDO”), consisting of (a) 1,642,871 shares having an exercise price of $22.72 per share and (b) 131,472 shares having an exercise price of $25.81 per share ((a) and (b) collectively, the “December 2024 Warrants” and together with the February 2024 BDO Warrants, the April 2024 RDO Warrants, and the October 2024 Warrants, the “2024 Warrants”).

The Prospectus and this prospectus supplement also relate to the offer and sale from time to time byFSF(including its permitted transferees, donees, pledgees and other successors-in-interest) (the “Selling Securityholder”) of up to an aggregate of3,250,000shares (the “Resale Shares”) of Common Stock issuable upon

exercise of a warrant to purchase 3,250,000 shares of Common Stock issued by us to the Selling Securityholder (the “Deposit Warrant”) pursuant to a Commitment Side Letter, dated June 11, 2024 between us andthe Selling Securityholder(the “Commitment Letter”), having an exercise price of $1.20 per share.

Our Common Stock is listed on the Nasdaq Capital Market under the symbol “SCLX”. On May 14, 2025, the last reported sales price per share of our Common Stock was $4.47.

On April 15, 2025, we effected a reverse stock split of our Common Stock at a ratio of 1-for-35 (the “Reverse Stock Split”). Unless otherwise noted, the share and per share information in the Prospectus reflects the effect of the Reverse Stock Split. The Company’s historical financial statements included in the Prospectus do not reflect the Reverse Stock Split.

This prospectus supplement updates and supplements