Company: SION
Filing Date: 2025-01-17
Form Type: S-1
Source: 0001193125-25-008474
Chunk: 362

Company: Sionna Therapeutics, Inc.
Filing Date: 2025-01-17
Form: S-1
Chunk 362
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| 4.2+    |     | Third Amended and Restated Investors’ Rights Agreement, by and between the Registrant and certain of its stockholders, dated as of March 4, 2024. |
| 5.1*    |     | Opinion of Goodwin Procter LLP.                                                                                                                   |
| 10.1

#   |     | 2020 Stock Option and Grant Plan and form of award agreements thereunder.                                                                         |
| 10.2*

#  |     | Sionna Therapeutics, Inc. 2025 Stock Option and Incentive Plan and form of award agreements thereunder.                                           |
II-3

| Exhibit 
 Number  |     | Description                                                                                                    |
| 10.3*

#  |     | Sionna Therapeutics, Inc. 2025 Employee Stock Purchase Plan.                                                   |
| 10.4*

#  |     | Form of Indemnification Agreement by and between the Registrant and its director and executive officers.       |
| 10.5

#   |     | Senior Executive Cash Incentive Bonus Plan.                                                                    |
| 10.6

#   |     | Severance and Change in Control Plan.                                                                          |
| 10.7*

#  |     | Non-Employee Director Compensation Policy.                                                                     |
| 10.8

#   |     | Compensation Recovery Policy.                                                                                  |
| 10.9†+  |     | License Agreement by and between the Registrant and Sanofi Genzyme, dated as of December 20, 2019, as amended. |
| 10.10†+ |     | License Agreement by and between the Registrant and AbbVie Global Enterprises Ltd., dated as of July 11, 2024. |
| 10.11†+ |     | Payment Agreement by and between the Registrant and Cystic Fibrosis Foundation, dated as of December 20, 2019. |
| 10.12#+ |     | Offer Letter by and between the Registrant and Michael Cloonan, dated as of March 8, 2021.                     |
| 10.13#+ |     | Offer Letter by and between the Registrant and Charlotte McKee, dated as of May 7, 2021.                       |
| 10.14#+ |     | Offer Letter by and between the Registrant and Elena Ridloff, dated as of August