Company: PRME
Filing Date: 2025-07-02
Form Type: PRE 14A
Source: 0001193125-25-155000
Chunk: 30

Company: Prime Medicine, Inc.
Filing Date: 2025-07-02
Form: PRE 14A
Chunk 30
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 INK AS FOLLOWS: V76797-S18152 KEEP THIS PORTION FOR YOUR RECORDS DETACH AND RETURN THIS PORTION ONLY THIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED. PRIME MEDICINE, INC. The Board of Directors recommends you vote FOR the following proposal: 1. To approve the repricing of certain outstanding stock options that have been granted under the Company’s 2019 Stock Option and Grant Plan and/or the 2022 Stock Option and Incentive Plan (the “Option Repricing Proposal”). For Against Abstain The Board of Directors recommends you vote FOR the following proposal: 2. To approve a proposal to adjourn the Special Meeting to a later date, if necessary or appropriate, to permit further solicitation and vote of additional proxies in the event that there are insufficient votes for, or otherwise in connection with, the approval of the Option Repricing Proposal at the time of the Special Meeting. “). For Against Abstain NOTE: Such other business as may properly come before the meeting or any continuations, adjournments, and postponements thereof. Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer. Signature [PLEASE SIGN WITHIN BOX] Date Signature (Joint Owners) Date

Important Notice Regarding the Availability of Proxy Materials for the 2025 Special Meeting of Stockholders to be Held on August 1, 2025: The Notice and Proxy Statement are available for viewing, printing and downloading at www.proxyvote.com. V76798-S18152 PRIME MEDICINE, INC. 2025 SPECIAL MEETING OF STOCKHOLDERS AUGUST 1, 2025 AT 1:00 PM ET THIS PROXY IS SOLICITED BY THE BOARD OF DIRECTORS The undersigned stockholder(s) hereby appoint(s) Allan Reine and Ryan Brown, or either of them, as proxies, each with the power to appoint his substitute, and hereby authorize(s) them to represent and to vote, as designated on the reverse side of this ballot, all of the shares of common stock of PRIME MEDICINE, INC. that the undersigned stockholder(s)is/are entitled to vote at the 2025 Special Meeting of Stockholders to be