Company: TAK
Filing Date: 2025-06-26
Form Type: 424B5
Source: 0001395064-25-000101
Chunk: 21

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-26
Form: 424B5
Chunk 21
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 Senior Debt Securities and Guarantee—Taxation and Additional Amounts—TUSFI” in the accompanying prospectus.

#### Guarantor
All payments of principal and interest by the Guarantor in respect of the Notes shall be made without withholding or deduction for or on account of any present or future taxes, duties, assessments or governmental charges of whatever nature imposed or levied by or on behalf of Japan, or any authority thereof or therein having power to tax, unless such withholding or deduction is required by law or by the authority. In such event, the Guarantor shall pay, subject to certain exceptions, such additional amounts as will result in the receipt by the holders

<div align='center'>S-15</div>

of such amounts as would have been received by them had no such withholding or deduction been required. For further information, see “Description of Senior Debt Securities and Guarantee—Taxation and Additional Amounts—TPC as an issuer” in the accompanying prospectus. For a discussion of the circumstances under which payments under the Guarantee may be subject to withholding under the laws of Japan, see “Taxation—Japanese Taxation”.

#### Redemption

#### Optional Redemption
The Issuer has the option to redeem the Notes of each series, in whole or in part, at any time and from time to time, prior to the applicable Par Call Date, at a redemption price (expressed as a percentage of principal amount and rounded to three decimal places) equal to the greater of:

(i) (a) the sum of the present values of the remaining scheduled payments of principal and interest thereon discounted to the redemption date (assuming the Notes being redeemed matured on the applicable Par Call Date) on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate plus the applicable Spread less (b) interest accrued to the date of redemption, and

(ii) 100% of the principal amount of the series of Notes being redeemed;

plus , in each case, accrued and unpaid interest thereon to, but excluding, the redemption date.

The “Par Call Date” for each series of the Notes will be as follows:

• For the 2035 Notes: , 20 (the date that is months before maturity); and

• For the 2055 Notes: , 20 (the date that is months before maturity).

The “Spread” for each series of the Notes will be as follows:

• For the 2035 Notes: basis points; and

• For the