Company: PFSA
Filing Date: 2025-10-07
Form Type: DEFA14A
Source: 0001213900-25-097058
Chunk: 0

Company: Profusa, Inc.
Filing Date: 2025-10-07
Form: DEFA14A
Chunk 0
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<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of

the Securities Exchange Act of 1934 (Amendment No. )</div>

Filed by the Registrant ☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:

| ☐ | Preliminary Proxy Statement |

| ☐ | Confidential, for Use of the Commission Only (as permitted 
 by Rule 14a-6(e)(2))                                       |

| ☐ | Definitive Proxy Statement |

| ☒ | Definitive Additional Materials |

| ☐ | Soliciting Material under §240.14a-12 |

<div align='center'>PROFUSA, INC.

(Name of Registrant as Specified in Its Charter)

(Name of Person(s) Filing
Proxy Statement, if other than the Registrant)</div>

Payment of Filing Fee (Check the appropriate box):

| ☐ | No fee required. |

| ☐ | Fee paid previously with preliminary materials. |

| ☐ | Fee computed on table in exhibit required by Item 25(b) per 
 Exchange Act Rules 14a6(i)(1) and 0-11.                     |

<div align='center'>PROFUSA, INC.

626 Bancroft Way

Suite A

Berkeley, CA 94710</div>

Dear Stockholder:

As you are aware, the Board of Directors of Profusa,
Inc. (the “Company,” “we,” or “our”) called a Special Meeting of Stockholders (the “Special
Meeting”) on October 7, 2025 at 10:00 A.M. Eastern Time, or at any adjournment or postponement thereof. On date of the Special Meeting,
the meeting was convened, and adjourned, without conducting any business because the Company did not have a sufficient number of shares
of the Company’s common stock present in person or represented by proxy at the Special Meeting to constitute a quorum. The adjourned
Special Meeting will reconvene on Monday, October 20, 2025 at 10:00 a.m. Eastern Time.

The information in this letter is intended to
supplement and amend certain information included in the definitive proxy statement relating to the Special Meeting, which was filed with
the Securities and Exchange Commission on September 23, 2025 (