Company: SCLXW
Filing Date: 2025-12-01
Form Type: 424B3
Source: 0001193125-25-303047
Chunk: 5

Company: Scilex Holding Co
Filing Date: 2025-12-01
Form: 424B3
Chunk 5
---
 Name: Henry Ji, Ph.D.                      |     |                     |
| Title: Chief Executive Officer & President |     |                     |

Date: December 1, 2025

Exhibit 99.1

Scilex Holding Company Announces Closing of Previously Announced Second Tranche Investment in Datavault AI Inc., Completing Its Two-TrancheEquity Financing in Datavault AI Inc.

| • |     | Scilex closed the second tranche, purchasing a pre-funded warrant                                                                                                                                            
 exercisable for 263,914,094 shares of Datavault AI Inc. (Nasdaq: DVLT; “Datavault AI”) common stock in Bitcoin (BTC) (based on the spot exchange rate of BTC as of the signing of the strategic investment). |

| • |     | Scilex has exercised the warrant in full and the shares of Datavault AI common stock issued upon such exercise                                                            
 have an approximate value of $583.3 million based on the closing price of $2.21 per share of Datavault AI common stock on the Nasdaq Capital Market on November 25, 2025. |

| • |     | Both companies will ramp up collaboration to deliver growth in Real World Asset tokenization in 2026 and beyond. |

PALO ALTO, CALIFORNIA – November 26, 2025 (GLOBE NEWSWIRE)—Scilex Holding Company (“Scilex” or the “Company”) (Nasdaq: SCLX), an innovative revenue-generating company focused on acquiring, developing and commercializing non-opioidpain management products for the treatment of acute and chronic pain and neurodegenerative and cardiometabolic disease, announced today that it has closed the second tranche of its strategic investment in Datavault AI in BTC (based on the spot exchange rate of BTC as of the signing of the strategic investment). The closing of this second tranche followed the approval by the Datavault stockholders at Datavault’s November 24, 2025 annual meeting of the issuance of the shares of Datavault common stock upon exercise of the pre-fundedwarrant. Scilex’s shares of Datavault common stock issued upon the exercise in full of the pre-fundedwarrant has an approximate value of $583.3 million based on the closing price of $2.21 per share of Datavault AI common stock on the Nasdaq Capital Market on November 25, 2025. For