Company: GHRS
Filing Date: 2025-02-05
Form Type: 424B5
Source: 0001140361-25-003183
Chunk: 62

Company: GH Research PLC
Filing Date: 2025-02-05
Form: 424B5
Chunk 62
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 to vote on the resolution in question). Conflicts of Interest Our directors have certain statutory and fiduciary duties as a matter of Irish law. All of the directors have equal and overall responsibility for management of our company (although directors who also serve as employees may have additional responsibilities and duties arising under their employment agreements (if applicable), and it is likely that more will be expected of them in compliance with their duties than non-executive directors). The Irish Companies Act provides specifically for certain fiduciary duties of the directors of Irish companies, including duties:

| • | to act in good faith and in the best interests of the company; |

| • | to act honestly and responsibly in relation to the company’s affairs; |

| • | to act in accordance with the company’s constitution and to exercise powers only for lawful purposes; |

| • | not to misuse the company’s property, information and/or opportunity; |

| • | not to fetter their independent judgment; |

| • | to avoid conflicts of interest; |

| • | to exercise care, skill and diligence; and |

| • | to have regard for the interests of the company’s shareholders. |

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#### TABLE OF CONTENTS
Other statutory duties of directors include ensuring the maintenance of proper books of account, having annual accounts prepared, having an annual audit performed, maintaining certain registers, making certain filings and disclosing personal interests. Directors of public limited companies such as ourselves will have a specific duty to ensure that the company secretary is a person with the requisite knowledge and experience to discharge the role. Directors may rely on information, opinions, reports or statements, including financial statements and other financial data, prepared or presented by (1) other directors, officers or employees of the company whom the director reasonably believes to be reliable and competent in the matters prepared or presented, (2) legal counsel, public accountants or other persons as to matters the director reasonably believes to be within their professional or expert competence or (3) a committee of the board of which the director does not serve as to matters within its designated authority, which committee the director reasonably believes to merit confidence.

Our Constitution provides that a director shall generally not vote at a meeting of the directors or a committee of directors on any resolution concerning a matter in which he or she has, directly or indirectly or together with any person or persons connected with him or her an interest which is material or a duty which conflicts or may conflict with the interests of the Company.

#### Directors’ and Officers’ Indemn