Company: SCLXW
Filing Date: 2025-12-01
Form Type: 424B3
Source: 0001193125-25-303054
Chunk: 9

Company: Scilex Holding Co
Filing Date: 2025-12-01
Form: 424B3
Chunk 9
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 the target patient
population, their willingness to try new therapies and the willingness of physicians to prescribe these therapies; risks that the prior results of the clinical trials may not be replicated; regulatory and intellectual property risks; the risk of
failure to realize the anticipated benefits of the transactions contemplated with Datavault and other risks and uncertainties

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indicated from time to time and other risks set forth in Scilex’s filings with the SEC. There may be additional risks that Scilex presently does not know or that Scilex currently believes
are immaterial that could also cause actual results to differ from those contained in the forward-looking statements. In addition, forward-looking statements provide Scilex’s expectations, plans or forecasts of future events and views as of
the date of the communication. Scilex anticipates that subsequent events and developments will cause such assessments to change. However, while Scilex may elect to update these forward-looking statements at some point in the future, Scilex
specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Scilex’s assessments as of any date subsequent to the date of this communication. Accordingly, investors are cautioned
not to place undue reliance on these forward-looking statements.

Contacts:

Investors and Media

Scilex Holding Company

960 San Antonio Road

Palo Alto, CA 94303

Office: (650) 516-4310

Email: investorrelations@scilexholding.com

Website:
www.scilexholding.com

# # #

SEMDEXA (SP-102) is a trademark owned by Semnur Pharmaceuticals, Inc., a majority-owned subsidiary of Scilex Holding Company. A proprietary name review by the FDA
is planned.

ZTlido is a registered trademark owned by Scilex Pharmaceuticals Inc., a
wholly-owned subsidiary of Scilex Holding Company.

Gloperba is the subject of an exclusive,
transferable license to use the registered trademark by Scilex Holding Company.

ELYXYB is a
registered trademark owned by Scilex Holding Company.

Scilex Bio is a trademark owned by
Scilex Holding Company, Inc.

All other trademarks are the property of their respective owners.

2025 Scilex Holding Company All Rights Reserved.

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