Company: FENC
Filing Date: 2025-11-18
Form Type: S-8
Source: 0001104659-25-113660
Chunk: 8

Company: FENNEC PHARMACEUTICALS INC.
Filing Date: 2025-11-18
Form: S-8
Chunk 8
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 meets all of the
requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of Research Triangle Park, State of North Carolina on November 18,
2025.

| Fennec Pharmaceuticals Inc. |                         |
| By:                         | /s/                     
 Jeffrey Hackman         |
|                             | Jeffrey Hackman         |
|                             | Chief Executive Officer |

<div align='center'>POWER OF ATTORNEY</div>

We, the undersigned directors
and officers of the Registrant, hereby severally constitute and appoint Jeff Hackman and Robert Andrade as our true and lawful attorneys,
with full power to them to sign for us and in our names in the capacities indicated below, the Registration Statement on Form S-8
filed herewith, and any and all amendments (including post-effective amendments) to said Registration Statement, and to file or cause
to be filed the same, with all exhibits thereto and other documents in connection therewith, with the Commission, granting unto said
attorneys, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done
in connection therewith, as fully to all intents and purposes as each of them might or could do in person, and hereby ratifying and confirming
all that said attorneys, and each of them, or their substitute or substitutes, shall do or cause to be done by virtue of this power of
attorney. This power of attorney does not revoke any power of attorney previously granted by the undersigned, or any of them.

Pursuant to the requirements
of the Securities Act, this Registration Statement has been signed by the following persons in the capacities indicated on the date indicated:

| Signature        
 /s/  Jeffrey     
 Hackman          |     | Title                          
 Chief                          
 Executive Officer and Director |     | Date         
 November 18, 
 2025         |
|:-----------------|:----|:-------------------------------|:----|:-------------|
| Jeffrey          
 Hackman          |     | -principal                     
 executive officer              |     |              |
| /s/              
 Robert Andrade   |     | Chief                          
 Financial Officer              |     | November 18, 
 2025         |
| Robert Andrade   |     | -principal financial           
 and accounting officer         |     |              |
| /s/              
 Dr. Khalid Islam |     | Director