Company: PAYX
Filing Date: 2025-04-09
Form Type: 424B2
Source: 0001193125-25-076822
Chunk: 61

Company: PAYCHEX INC
Filing Date: 2025-04-09
Form: 424B2
Chunk 61
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 Prospectus                                |     |      |  1 |
| Cautionary Note Regarding Forward-Looking Statements |     |      |  2 |
| About the Company                                    |     |      |  4 |
| Risk Factors                                         |     |      |  5 |
| Use of Proceeds                                      |     |      |  6 |
| Description of Debt Securities                       |     |      |  7 |
| Plan of Distribution                                 |     |      | 16 |
| Legal Matters                                        |     |      | 18 |
| Experts                                              |     |      | 18 |
| Where You Can Find More Information                  |     |      | 19 |
| Incorporation of Certain Documents by Reference      |     |      | 19 |

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ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and
Exchange Commission, or SEC, using the “shelf” registration process. Under this shelf registration process, we may sell any combination of the securities described in this prospectus in one or more offerings. This prospectus provides you
with a general description of the securities we may offer. Each time we sell securities, we will provide a prospectus supplement that will contain specific information about the terms of that offering. The prospectus supplement may also add, update
or change information contained in this prospectus. Any statement that we make in this prospectus will be modified or superseded by any inconsistent statement made by us in a prospectus supplement.

You should read both this prospectus and any applicable prospectus supplement together with the additional information about our company to
which we refer you in the section of this prospectus entitled “Where You Can Find More Information.” If there is any inconsistency between the information in this prospectus and any prospectus supplement, you should rely on the information
in the applicable prospectus supplement.

We have not authorized anyone to provide any information other than that contained or
incorporated by reference in this prospectus (as supplemented and amended) or in any free writing prospectus prepared by or on behalf of us or to which we have referred you. We take no responsibility for, and can provide no assurance as to the
reliability of, any other information that others may give you. The securities are not being offered in any jurisdiction where the offer or sale is not permitted. You should not assume that the information contained in this prospectus and any
accompanying prospectus supplement