Company: NCNA
Filing Date: 2025-06-20
Form Type: 6-K
Source: 0001193125-25-143671
Chunk: 1

Company: NuCana plc
Filing Date: 2025-06-20
Form: 6-K
Chunk 1
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 Market.

If the Company is not able to cure the deficiency within the 180-day compliance period, or any extension that
Nasdaq may grant in its sole discretion, Nasdaq will provide notice that the Company’s ADSs will be subject to delisting. The Company would then be entitled to appeal that determination to a Nasdaq Listing Qualifications Panel (the
“Panel”). However, there can be no assurance that, if the Company receives a delisting notice and appeals the delisting determination by Nasdaq to the Panel, such appeal would be successful.

The Company intends to actively monitor the closing bid price of its ADSs and may, if appropriate, consider implementing available options to regain
compliance with the Bid Price Requirement under the Nasdaq Listing Rules.

The information in this Form 6-K shall
be deemed to be incorporated by reference into the registration statements on Form F-3, as amended (File Number 333-281576) and Form
S-8 (File Number 333-223476 and File Number 333-248135), and related prospectuses, as such registration statements and
prospectuses may be amended from time to time, and to be a part thereof from the date on which this report is filed, to the extent not superseded by documents or reports subsequently filed or furnished.

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

| NuCana plc |     |                                 |
| By:        |     | /s/ Ian Webster                 |
| Name:      |     | Ian Webster                     |
| Title:     |     | Interim Chief Financial Officer |

Date: June 20, 2025