Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 60

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 60
---
 to this prospectus will be deposited by us with the custodian. Upon receipt of confirmation of such deposit, the depositary will issue ADSs pursuant to our instruction. The depositary may create ADSs on your behalf if you or your broker deposit ordinary shares with the custodian. The depositary will deliver these ADSs to the person you indicate only after you pay any applicable issuance fees and any charges and taxes payable for the transfer of the ordinary shares to the custodian and provide such documentation as may be required pursuant to the deposit agreement. Your ability to deposit ordinary shares and receive ADSs may be limited by U.S. and England and Wales legal considerations applicable at the time of deposit. The issuance of ADSs may be delayed until the depositary or the custodian receives confirmation that all required approvals have been given and that the ordinary shares have been duly transferred to the custodian. The depositary will only issue ADSs in whole numbers. When you make a deposit of ordinary shares, you will be responsible for transferring good and valid title to the depositary. As such, you will be deemed to represent and warrant that:

| • |     | the ordinary shares are duly authorized, validly allotted and issued, fully paid, not subject to any call for the 
 payment of further capital and legally obtained;                                                                  |

| • |     | all preemptive (and similar) rights, if any, with respect to such ordinary shares have been validly waived, 
 disapplied or exercised;                                                                                    |

| • |     | you are duly authorized to deposit the ordinary shares; |

| • |     | the ordinary shares presented for deposit are free and clear of any lien, encumbrance, security interest, charge,                                               
 mortgage or adverse claim, and are not, and the ADSs issuable upon such deposit will not be, “restricted securities” (as defined in the deposit agreement); and |

| • |     | the ordinary shares presented for deposit have not been stripped of any rights or entitlements. |

If any of the representations or warranties are incorrect in any way, we and the depositary may, at your cost and expense, take any and all actions necessary to correct the consequences of the misrepresentations. Transfer, Combination and Split Up of ADRs As an ADR holder, you will be entitled to transfer, combine or split up your ADRs and the ADSs evidenced thereby. For transfers of ADRs, you will have to surrender the ADRs to be transferred to the depositary