Company: LENZ
Filing Date: 2025-04-04
Form Type: S-3
Source: 0001628280-25-016822
Chunk: 55

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-04
Form: S-3
Chunk 55
---
 other than those documents or the portions of those documents furnished pursuant to Items 2.02 or 7.01 of any Current Report on Form 8-K and, except as may be noted in any such Form 8-K, exhibits filed on such form that are related to such information) after the date of the initial registration statement of which this prospectus forms a part and prior to the effectiveness of the registration statement, as well as subsequent to the effectiveness of the registration statement, until the offering of the securities under the registration statement of which this prospectus supplement forms a part is terminated or completed:

• our Annual Report on Form 10-K for the year ended December 31, 2024, filed with the SEC on March 19, 2025 ; and

• the description of our Common Stock contained in the Annual Report on Form 10-K filed on March 19, 2025 .

You may request a copy of these filings, at no cost, by writing or telephoning us at the following address and telephone number:

<div align='center'>LENZ Therapeutics, Inc.

201 Lomas Santa Fe Dr., Suite 300

Solana Beach, California 92075

Attn: Investor Relations

(858) 925-7000

S-17</div>

#### Up to $150,000,000

#### Common Stock

### PROSPECTUS SUPPLEMENT
| TD Cowen |

#### , 2025

# PART II

### INFORMATION NOT REQUIRED IN PROSPECTUS

## Item 14. Other Expenses of Issuance and Distribution
The following table sets forth fees and expenses to be paid by us in connection with the issuance and distribution of the securities being registered, other than discounts and commissions to be paid to agents or underwriters. All amounts shown are estimates except for the Securities and Exchange Commission, or the SEC, registration fee.

|                                                |     | Amount                
 to be Paid            |        |
|:-----------------------------------------------|:----|:----------------------|-------:|
| SEC registration fee                           |     | $                     | 76,550 |
| Stock exchange listing fee                     |     | *                     |        |
| Printing and engraving expenses                |     | *                     |        |
| Accounting fees and expenses                   |     | *                     |        |
| Legal fees and expenses                        |     | *                     |        |
| Transfer agent and registrar fees and expenses |     | *                     |        |
| Trustee’s fees and expenses