Company: SHPH
Filing Date: 2025-04-10
Form Type: PRER14A
Source: 0001641172-25-003635
Chunk: 52

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-04-10
Form: PRER14A
Chunk 52
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the “ reverse stock split”). From and after the Effective Time, certificates representing the Old Common Stock shall represent the number of shares of New Common Stock into which such Old Common Stock shall have been combined pursuant to this Certificate of Amendment. Holders who otherwise would be entitled to receive fractional share interests of New Common Stock upon the effectiveness of the reverse stock split shall be entitled to receive a whole share of New Common Stock in lieu of any fractional share created as a result of such reverse stock split.”

3. That this Certificate of Amendment shall be effective as of [ ] p.m. ET on [ ], 2025.

4. Except as set forth in this Certificate of Amendment, the Amended and Restated Certificate of Incorporation, as previously amended, remains in full force and effect.

IN WITNESS WHEREOF, this Certificate of Amendment has been executed by a duly authorized officer of the Corporation on this [ ] day of [ ], 2025.

| Anatoly                   
 Dritschilo                |
| Chairman                  
 of the Board of Directors |

Appendix B

<div align='center'>AMENDMENT NO. 1

TO

SHUTTLE PHARMACEUTICALS HOLDINGS, INC.

2018 EQUITY INCENTIVE PLAN</div>

WHEREAS,the Board of Directors (the “Board”) of Shuttle Pharmaceuticals Holdings, Inc. (the “Company”) heretofore
established, and the Company’s shareholders have approved, the 2018 Equity Incentive Plan (the “Plan”); and

WHEREAS,
the Company desires to amend the Plan to increase the number of shares available for issuance under the Plan by 5,000,000 shares;

WHEREAS,
Section 18(a) of the Plan permits the Board to amend the Plan, subject, in the case of amendments requiring shareholder approval under
the rules of any securities exchange on which the shares may then be listed, to the approval by the Company’s shareholders of such
amendment;

WHEREAS,
this amendment shall be submitted to the Company’s shareholders for approval and, contingent on such approval, shall become effective
as of the date on which the Company’s shareholders approve such amendment (the “Effective Date”);

WHEREAS,
if the Company’s shareholders fail to approve this amendment, the existing Plan shall continue in full force and effect;

NOW, THEREFORE, BE IT RESOLVED, pursuant to Section 18(a) of the Plan, provided the Company’s shareholders approve this amendment,
the Plan shall be amended as follows