Company: PAYX
Filing Date: 2025-04-08
Form Type: 424B2
Source: 0001193125-25-075170
Chunk: 79

Company: PAYCHEX INC
Filing Date: 2025-04-08
Form: 424B2
Chunk 79
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 we may make with
the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) on or after the date of this prospectus and prior to the termination of any offering under this prospectus and any
prospectus supplement; provided, however, that we are not incorporating, in each case, any documents or information deemed to have been furnished and not filed in accordance with SEC rules (including Items 2.02 and 7.01 of Form 8-K):

1. Our Annual Report on Form 10-K for the fiscal year ended May 31, 2024, filed with the SEC on July 11, 2024;

2. The information specifically incorporated by reference into the Annual Report on Form 10-K for the
fiscal year ended May 31, 2024 from our definitive proxy statement on Schedule 14A, filed with the SEC on
August 30, 2024, for our 2024 annual meeting of stockholders;

3. Our Quarterly Reports on Form
10-Q for the quarter ended August31, 2024, filed with the SEC
October 1, 2024, for the quarter ended November30, 2024, filed with the SEC December 19,
2024 and for the quarter ended February 28, 2025, filed with the SEC March 26, 2025; and

4. Our Current Reports on Form 8-K filed with the SEC on June17, 2024, October11, 2024, January7, 2025 and February27, 2025.

You may obtain a copy of any or all of the documents referred to above which may have been or may be incorporated by reference into this
prospectus, except for exhibits to those documents (unless the exhibits are specifically incorporated by reference into those documents) at no cost to you by writing to us at the following address:

Paychex, Inc.

911 Panorama Trail
South

Rochester, New York 14625-2396

Attn: Corporate Secretary

Telephone: (585) 385-6666

19

$ PAYCHEX, INC. $ % Notes due 20 $ % Notes due 20 $ % Notes due 20 Prospectus Supplement Joint Book-Running Managers

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