Company: SHPH
Filing Date: 2025-01-24
Form Type: 424B3
Source: 0001493152-25-003508
Chunk: 0

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-01-24
Form: 424B3
Chunk 0
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Filed Pursuant to Rule 424(b)(3)

Registration Statement No. 333-284286

PROSPECTUS

<div align='center'>Up to 1,464,268 Shares of Common Stock Issuable Upon Conversion of 14.5% Senior Secured Convertible Notes

Up to 329,461 Shares of Common Stock Issuable Upon Exercise of Warrants</div>

This prospectus relates to the resale from time to time of (i) up to 1,464,268 shares of common stock underlying $831,579 in convertible notes (the “Convertible Notes”), which represents 200% of the maximum number of shares of common stock issuable upon conversion of the Convertible Notes, and (ii) 329,461 shares of common stock issuable upon exercise of warrants (the “Warrants”), each of which were issued in an October 2024 private placement to the selling stockholders named in this prospectus (the aggregate 1,793,729 shares of common stock being registered that underly the Convertible Notes and Warrants, together, the “Shares”). In compliance with Nasdaq Rule 5635(e), the Company will not issue more than 19.99% of the Company’s common stock issuable under the Convertible Notes, calculated as of October 21, 2024, without first obtaining stockholder approval.

We are not selling any securities under this prospectus and will not receive any of the proceeds from the sale of the Shares by the selling stockholders, except with respect to amounts received by us upon the selling stockholders’ exercise of Warrants to the extent such Warrants are exercised for cash. We may receive up to an aggregate of approximately $469,214 from the exercise of all Warrants, assuming they are exercised in full for a weighted-average cash price of $1.42 per share of common stock, assuming no anti-dilution adjustments or other adjustments as set forth in the Warrants. We will pay all expenses associated with the sale of common stock pursuant to this prospectus.

The selling stockholders may sell or otherwise dispose of the common stock described in this prospectus in a number of different ways and at varying prices. See “Plan of Distribution” for more information about how the selling stockholders may sell or otherwise dispose of the common stock being registered pursuant to this prospectus.

Our common stock trades on The Nasdaq Capital Market under the symbol “SHPH.” On January 23, 2025, the last reported sale price of