Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063899
Chunk: 287

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 287
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RNAs as
biomarkers of Rett syndrome.

NIH/NIA SBIR Phase IIB Grant Number 2R44AG044860-04
03/01/2017 – 08/28/2020

Title: Brain-enriched microRNAs detectable in
plasma as biomarkers of Alzheimer’s disease.

The main goal of this Phase IIB study is to establish
reliable pre-analytical protocol and analytical workflow for detection of brain-enriched microRNAs in plasma of AD patients and control
subjects.

NIH/NIA, Grant Number 3R44AG044860-06S1 (Admin.
Suppl.) 09/01/2019 – 02/28/2020

Title: Brain-enriched microRNAs detectable in
plasma as biomarkers of Alzheimer’s disease.

Alzheimer’s Drug Discovery Foundation. Ref
#: 201809-2016425 11/11/2019 – 11/10/2020

Title: Circulating brain-enriched microRNAs as
peripheral biomarkers of neurodegeneration.

The main goal of this project is to assess associations
between circulating brain-enriched microRNAs and known AD markers in preclinical AD samples from A4 prevention study.

NIH/NIA SBIR Phase II Grant Number 2R44AG044860-02
02/15/2015 – 01/31/2017

Title: Early detection of Alzheimer’s (MCI
stage): Analysis of plasma cell-free miRNA.

The goal of this Phase II study was to provide
further validation for the MCI microRNA signature using plasma samples from well-characterized heterogeneous cohorts and to define microRNA
biomarker signatures for predicting AD “progressors” and for differentiating AD from other neurodegenerative diseases.

NIH/NIA SBIR Phase I Grant Number 1R43AG053116-01
06/01/2016 – 11/30/2016

Title: Circulating organ-enriched microRNAs as
biomarkers of aging

The goal of this study was to analyze brain-enriched
microRNA signatures detectable in plasma in the context of normal aging; the study was conducted in collaboration with the New York Blood
Center.

Rett Syndrome Research Trust (2014 and 2015 awards)
12/01/2014 – 04/30/2016

Title: Analysis of circulating