Company: TVRD
Filing Date: 2025-01-27
Form Type: S-4/A
Source: 0001104659-25-006050
Chunk: 676

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-01-27
Form: S-4/A
Chunk 676
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 proxy statement/prospectus shall, under any circumstances, create any implication that there has been no change in the information set forth or incorporated into this proxy statement/prospectus by reference or in Cara’s affairs since the date of this proxy statement/prospectus.

Cara has supplied all information contained in this proxy statement/prospectus relating to Cara and its business, and Tvardi has supplied all information contained in this proxy statement/prospectus relating to Tvardi and its business.

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Neither Cara nor Tvardi has authorized anyone to give any information or make any representation about the Merger or Cara or Tvardi that is different from, or in addition to, that contained in this proxy statement/prospectus. Therefore, if anyone does give you information of this sort, you should not rely on it. The information contained in this proxy statement/prospectus speaks only as of the date of this proxy statement/prospectus unless the information specifically indicates that another date applies. If you would like to request documents from Cara or Tvardi, please send a request in writing or by telephone to either Cara or Tvardi at the following addresses or telephone numbers:

| Cara Therapeutics, Inc.  | Tvardi Therapeutics, Inc.  |
| 400 Atlantic Street      | 3 Sugar Creek Center Blvd. |
| Suite 500                | Suite 525                  |
| Stamford, CT 06901       | Sugar Land, TX 77478       |
| (203) 406-3700           | (713) 489-8654             |
| Attn: Investor Relations | Attn: Investor Relations   |

You may also request additional copies from Cara’s proxy solicitor using the following contact information: ALLIANCE
ADVISORS, LLC Stockholders call toll-free:
844-876-6183 Email:
CARA@allianceadvisors.com Householding of Proxy Materials The SEC has adopted rules that permit companies and intermediaries ( e.g., brokers) to satisfy the delivery requirements for proxy statements and annual reports with respect to two or more stockholders sharing the same address by delivering a single proxy statement addressed to those stockholders. This process, which is commonly referred to as “householding,” potentially means extra convenience for stockholders and cost savings for companies. A number of brokers with account holders who are Cara stockholders will be householding Cara’s proxy materials. A single proxy statement/prospectus will be delivered to multiple stockholders sharing an