Company: TVRD
Filing Date: 2025-10-20
Form Type: S-1/A
Source: 0001104659-25-100896
Chunk: 4

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-10-20
Form: S-1/A
Chunk 4
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, at prevailing market prices at the time of sale, at prices related to the prevailing market price, at varying prices determined at the time of sale, or at negotiated prices. In connection with any sales of shares of common stock offered hereunder, the selling stockholders and any underwriters, agents, brokers or dealers participating in such sales will be deemed to be “underwriters” within the meaning of the Securities Act.

The selling stockholders may sell any, all or none of the shares of common stock and we do not know when or in what amount the selling stockholders may sell their shares of common stock hereunder following the effective date of this registration statement.

Our common stock is listed on The Nasdaq Capital Market (“Nasdaq”) under the symbol “TVRD.” On October 17, 2025, the last quoted sale price for our common stock as reported on Nasdaq was $6.58.

Investing in our securities involves a high degree of risk. Before buying any securities, you should carefully read the discussion of the risks of investing in our securities in the section titled “Risk Factors” beginning on page 5of this prospectus.

You should rely only on the information contained in this prospectus or any prospectus supplement or amendment hereto. We have not authorized anyone to provide you with different information.

Neither the Securities Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.**

#### The date of this prospectus is           , 2025.
TABLE OF CONTENTS

TABLE OF CONTENTS

| ​                                                                                               | ​ | ​ | Page |   |     |   | ​ |
| ABOUT THIS PROSPECTUS                                                                           | ​ | ​ | ​    | ​ |   1 | ​ | ​ |
| MARKET AND INDUSTRY DATA                                                                        | ​ | ​ | ​    | ​ |   1 | ​ | ​ |
| TRADEMARKS                                                                                      | ​ | ​ | ​    | ​ |   1 | ​ | ​ |
| PROSPECTUS SUMMARY                                                                              | ​ | ​ | ​    | ​ |   2 | ​ | ​ |
| RISK FACTORS                                                                                    | ​ | ​ | ​    | ​ |   5 | ​ | ​ |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS                                            |