Company: NCEL
Filing Date: 2025-09-10
Form Type: 424B3
Source: 0001213900-25-086600
Chunk: 385

Company: NewcelX Ltd.
Filing Date: 2025-09-10
Form: 424B3
Chunk 385
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 suggesting that NLS -8may improve memory and reduce cognitive symptoms of AD. These effects were significant at doses of 50 and 150 mg/kg and was close to significant at the dose of 100 mg/kg. NLS-11 NLS -11(Benedin) (formerly SCH -5472) is a norepinephrine and dopaminereuptake inhibitor and muscarinic M1, M2, M3 receptor antagonist. In a preclinical study, 57BL/6 male mice, 8 groups (N = 16 mice/group), were subjected to the effect of NLS -11(0.1, 0.5, 1 mg/kg) and compared to those of vehicle and of donepezil (2 mg/kg). Long -termepisodic memory was tested in the NOR test, using a 3 -daysinterval between the acquisition session (called sample trial) and the retention session (called choice trial). The results of the study showed NLS -11improved the recognition of the familiar object, i.e., improved memory and suggest that NLS -11induced a long -termmemory improvement which was significant and of the same extent to that induced by donepezil. At doses tested, NLS -11did not reduce exploratory behavior, contrary to donepezil, suggesting that NLS -11may induce less side effect than donepezil. NLS-12 NLS -12(Oxafuramine) is a norepinephrine and dopamine reuptake inhibitor and muscarinic M4 receptor antagonist, improved long -termepisodic memory in mice. Donepezil was used as positive control drug. A preclinical study was conducted to observe the effects of NLS -12on the memory in the novel object recognition test in mice. The dose -rangingstudy using C57BL/6 male mice: 8 groups (N = 16 mice/group) were subjected to the effect of NLS -12(1,4, 8 mg/kg) and compared to those of vehicle and of donepezil (2 mg/kg). Long -termepisodic memory was tested in the NOR test, using a 3 -daysinterval between the acquisition session (called sample trial) and the retention session (called choice trial). NLS -12dose -dependentlyimproved the recognition of the familiar object, i.e., improved memory. This effect was significant at 8 mg/kg and was not significantly different