Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 376

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 376
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 subject to proration, for service on our Board and its committees as follows:

| Annual Cash Compensation                                                                    |     | Amount |        |
|:--------------------------------------------------------------------------------------------|:----|:-------|-------:|
| Board Members                                                                               |     | $      | 82,500 |
| Chairs of the Audit Committee, Compensation Committee, Nominating and Corporate Governance  
 Committee and Commercialization and Transaction Committee                                   |     | $      | 37,500 |
| Members of the Audit Committee, Compensation Committee, Nominating and Corporate Governance 
 Committee and Commercialization and Transaction Committee                                   |     | $      | 15,000 |
| Equity Compensation                                                                         |     | Number |        |
| Initial Stock Options                                                                       |     |        |  7,142 |
| Annual Stock Options                                                                        |     |        |  2,857 |

All annual cash compensation amounts for our non-employeedirectors are payable in equal quarterly installments in arrears, following the end of each quarter in which the service occurred, pro-ratedfor any partial months of service. The equity compensation paid to our non-employeedirectors will vest monthly over a period of 48 months from the date of grant with respect to the initial stock option grants and over a period of 12 months from the date of grant with respect to the annual stock option grants, in each case, subject to continued service through each vesting date. Additionally, we will reimburse each outside director for reasonable travel expenses related to such director’s attendance at Board and committee meetings. Employee directors receive no additional compensation for their service as a director. 239

CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS

The following is a summary of transactions since January 1, 2023 and any currently proposed transactions to which the Company was or is
to be a participant in which the amount involved exceeded or will exceed $120,000 or one percent of the average of the Company’s total assets as of December 31, 2024 for the last two completed fiscal years, and in which any of the
Company’s directors, executive officers or, to the Company’s knowledge, beneficial owners of more than 5% of the Company’s capital stock, or their immediate family members have had or will have a direct or indirect material interest,
other than compensation and other arrangements that are described under the sections of this prospectus titled “Executive and Director Compensation.”

Stockholder Agreement with Sorrento

On September 12, 2022, Vickers entered