Company: REVB
Filing Date: 2025-05-20
Form Type: S-1
Source: 0001213900-25-045828
Chunk: 101

Company: REVELATION BIOSCIENCES, INC.
Filing Date: 2025-05-20
Form: S-1
Chunk 101
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, steam, radiation from X-rays or radiotherapy, sunlight, or ultraviolet light. Chemical burns can be divided into acid or alkali burns. Alkali burns tend to be more severe, causing more penetration deeper into the skin by liquefying the skin (liquefaction necrosis). Acid burns penetrate less because they cause a coagulation injury (coagulation necrosis). Electrical burns typically have small entry and exit wounds but may also comprise extensive internal organ injury or associated traumatic injuries. Thermal burns are the most common type of burn. Approximately 86% of burns are caused by thermal injury such as fire or hot liquid, while about 4% are electrical and 3% are chemical. Flame and scald burns are the leading cause of burns in children and adults. More adults are injured with flame burns, while children younger than five years old are more often injured with scald burns. Burn injuries more commonly affect people of low and middle income and people in low-income countries (Schaefer 2023). Every year, approximately half a million Americans sustain burn injuries requiring medical intervention. While most burn injuries do not require admission to a hospital, about 40,000 patients are admitted, with approximately 30,000 of them needing specialized treatment at a certified burn center (Norbury, 2016; American Burn Association, 2024). The total annual number of burn-related deaths is approximately 3,400, with invasive infection being the primary reason for death after the first 24 hours (Norbury, 2016). The overall mortality rate for severe burn patients is about 3.3%, but this increases to 20.6% in burn patients with cutaneous burn and inhalation injury, versus 10.5% for inhalation injury alone (American Burn Association, 2024). 59 Invasive infection including sepsis is the primary cause of death after burn injury, accounting for an estimated 51% of deaths. The most frequent clinical complications reported in patients admitted to a certified burn center were pneumonia (3.5%), cellulitis (3%), and urinary tract infection (2.6%). The frequency of pneumonia was greater in patients who had been injured by fire, and those with four or more days of mechanical ventilation (Norbury, 2016). Current Prevention, Treatment, and Detection Options Prevention and Treatment of AKI There are currently no therapeutics to prevent or treat AKI. Treatment for AKI requires hospitalization and intensive supportive care until kidney function recovers. In more