Company: APM
Filing Date: 2025-10-06
Form Type: S-4
Source: 0001213900-25-096656
Chunk: 28

Company: Aptorum Group Ltd
Filing Date: 2025-10-06
Form: S-4
Chunk 28
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 common stock of the Combined Company remains trading on the Nasdaq Capital Market. If such listing condition is not met, the Merger will not be consummated unless the condition is waived. The Nasdaq condition set forth in the Merger Agreement is not expected to be waived by the applicable parties. On October2, 2025 the last trading day before the date of this proxy statement/prospectus, the closing sale price of Aptorum Class A ordinary shares was $2.21 per share. Q:Who will be the directors of the Combined Company following the Merger? A:Immediately following the Merger, the Combined Company board of directors (the “Combined Company Board”) will be composed of five (5) members, two (2) of whom have been designated by DiamiR Primary Stockholder Parties (as defined below) and three (3) of whom has been designated by Aptorum. Effective as of the Effective Time, assuming the Director Election Proposal passes, the following DiamiR designees: Kira Sheinerman, Ph.D., MBA., and Laura A. Philips, Ph.D., MBA., and the following Aptorum designees: Ian Huen, Justin Wu, and Douglas Arner will be appointed to the Combined Company’s board of directors. Ian Huen is expected to be appointed as Chair of the board of directors of the Combined Company. Alidad Mireskandari, Ph.D., MBA will be appointed as a non -votingobserver to the Board of the Combined Company. The current staggered structure of the Aptorum Board will adjust to a single class of directors for the Combined Company following the completion of the Merger. For additional information, please see the section titled “ Board of directors and management of the combined company after consummation of the Merger.” Q:Who will be the executive officers of the Combined Company immediately following the Merger? A:Immediately following the Merger, the executive management team of the Combined Company is expected to consist of members of the Aptorum and DiamiR executive management team prior to the Merger, including:

| Name                |     | Title                              |
| Ian Huen            |     | Chief Executive Officer            |
| Gary Anthony        |     | Chief Financial Officer            |
| Alidad Mireskandari |     | President, Chief Operating Officer |

Q:As an Aptorum shareholder, how does the Aptorum Board recommend that I vote? A:The Aptorum Board, in consultation with legal advisors and management, evaluated the