Company: DNLI
Filing Date: 2025-02-27
Form Type: S-8
Source: 0001714899-25-000068
Chunk: 4

Company: Denali Therapeutics Inc.
Filing Date: 2025-02-27
Form: S-8
Chunk 4
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 directors, officers or certain other employees.

The registrant expects to obtain and maintain insurance policies under which its directors and officers are insured, within the limits and subject to the limitations of those policies, against certain expenses in connection with the defense of, and certain liabilities which might be imposed as a result of, actions, suits or proceedings to which they are parties by reason of being or having been directors or officers. The coverage provided by these policies may apply whether or not the registrant would have the power to indemnify such person against such liability under the provisions of the Delaware General Corporation Law.

These indemnification provisions and the indemnification agreements entered into between the registrant and the registrant’s officers and directors may be sufficiently broad to permit indemnification of the registrant’s officers and directors for liabilities (including reimbursement of expenses incurred) arising under the Securities Act of 1933, as amended.

The underwriting agreement between the registrant and the underwriters to be filed as Exhibit 1.1 to this registration statement provides for the indemnification by the underwriters of the registrant’s directors and officers and certain controlling persons against specified liabilities, including liabilities under the Securities Act with respect to information provided by the underwriters specifically for inclusion in the registration statement.

## Item 7.

#### Exemption from Registration Claimed.
Not applicable.

## Item 8.

#### Exhibits.
|         |     |                                                                                                         |     | Incorporated by Reference |     |            |     |         |     |                |
| Exhibit 
 Number  |     | Description                                                                                             |     | Form                      |     | File No.   |     | Exhibit |     | Filing Date    |
| 4.1     |     | Specimen Common Stock Certificate of the Registrant                                                     |     | S-1/A                     |     | 333-221522 |     |     4.2 |     | 11/27/2017     |
| 4.2     |     | 2017 Equity Incentive Plan and forms of agreements thereunder                                           |     | S-1/A                     |     | 333-221522 |     |    10.3 |     | 11/27/2017     |
| 4.3     |     | 2017 Employee Stock Purchase Plan and form of agreement thereunder                                      |     | S-1/A                     |     | 333-221522 |     |    10.4 |     | 12/7/2017      |