Company: NCNA
Filing Date: 2025-06-27
Form Type: 424B5
Source: 0001193125-25-151464
Chunk: 9

Company: NuCana plc
Filing Date: 2025-06-27
Form: 424B5
Chunk 9
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 public interest concerns due to the dilutive nature of the transaction, or
any other reason, The Nasdaq Stock Market may issue a determination letter to delist our ADSs pursuant to its discretionary authority under Nasdaq Listing Rule 5101. In that event, even if we were to timely request a hearing with respect to The
Nasdaq Stock Market’s determination to delist our ADSs, The Nasdaq Stock Market may still impose an immediate halt on the trading of our ADSs pursuant to Nasdaq Listing Rule 4120(a)(5) pending the outcome of such hearing. If trading in our ADSs
were to be halted or if The Nasdaq Stock Market were to determine to delist our ADSs, investors could lose all or part of their investment and our ability to raise additional capital through the public or private sale of equity securities would be
adversely affected.

The price of our ADSs may remain below the minimum bid price requirement required by the Nasdaq Listing Rules, including Nasdaq Listing Rules 5550(a)(2) and 5810(c)(3)(A)(iii), which could result in our ADSs being delisted from The Nasdaq Capital Market. A delisting of our ADSs from The Nasdaq Capital Market could adversely affect our ability to raise additional capital through the public or private sale of equity securities, the ability of investors to dispose of ADSs or obtain accurate quotations as to the market value of our ADSs and the price and value of our ADSs.

Our ADSs are currently listed on The Nasdaq Capital Market. Continued listing of a security on The Nasdaq Capital Market is conditioned upon
compliance with various continued listing standards. In particular, the requirements for The Nasdaq Capital Market impose a minimum $1.00 per share bid price requirement. To comply with this requirement, the closing price for our ADSs must not fall
below $1.00 for a 30 consecutive trading day period. We were unable to maintain a minimum closing price of $1.00 per ADS for 30 consecutive

S-7

trading days, and received a deficiency letter from the staff of The Nasdaq Stock Market, or the Staff. The Staff provided us with a 180-calendar day grace period to regain compliance with the
bid price requirement.

However, if our ADSs have a closing bid price of $0.10 or less for ten consecutive trading days, the Staff must
issue a delisting determination to us and no grace period to regain compliance will be