Company: TAK
Filing Date: 2025-10-30
Form Type: 6-K
Source: 0001395064-25-000152
Chunk: 2

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-10-30
Form: 6-K
Chunk 2
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 Exchange Rate (CER) basis as its Management Guidance. The full year management guidance for the fiscal year ending March 31, 2026 (FY2025) has been revised from the management guidance announced on May 8, 2025.

The definition of Constant Exchange Rate change is stated in “Definition and Explanation of Non-IFRS Measures and U.S. Dollar Convenience Translations” in the Financial Appendix.

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#### Additional Information
| (1) Significant changes in the scope of consolidation during the period                |     | : No |     |                      |
| (2) Changes in accounting policies and changes in accounting estimates                 |     |      |     |                      |
| 1) Changes in accounting policies required by IFRS                                     |     | : No |     |                      |
| 2) Changes in accounting policies other than 1)                                        |     | : No |     |                      |
| 3) Changes in accounting estimates                                                     |     | : No |     |                      |
| (3) Number of shares outstanding (common stock)                                        |     |      |     |                      |
| 1) Number of shares outstanding (including treasury stock) at period end:              |     |      |     |                      |
| September 30, 2025                                                                     |     |      |     | 1,590,985,809 shares |
| March 31, 2025                                                                         |     |      |     | 1,590,949,609 shares |
| 2) Number of shares of treasury stock at period end:                                   |     |      |     |                      |
| September 30, 2025                                                                     |     |      |     | 11,391,535 shares    |
| March 31, 2025                                                                         |     |      |     | 17,299,963 shares    |
| 3) Average number of outstanding shares (for the six-month period ended September 30): |     |      |     |                      |
| September 30, 2025                                                                     |     |      |     | 1,571,098,080 shares |
| September 30, 2024                                                                     |     |      |     | 1,575,881,562 shares |

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Earnings report (Kessan Tanshin) is exempt from review conducted by certified public accountants or an audit firm.

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Note to ensure appropriate use of forecasts and guidance, and other noteworthy items