Company: TVRD
Filing Date: 2025-11-13
Form Type: 424B3
Source: 0001104659-25-111336
Chunk: 191

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-11-13
Form: 424B3
Chunk 191
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 resulting in unauthorized access to,
or acquisition, release or transfer of personal information or other data, may result in enforcement actions and prosecutions, private
litigation, significant fines, penalties and censure, claims for damages by customers and other affected individuals, regulatory inquiries
and investigations or adverse publicity and could cause its relevant stakeholders to lose trust in Tvardi, any of which could adversely
affect its business, financial condition, results of operations and prospects.

​

The successful assertion of one or more large claims
against Tvardi that exceeds its available insurance coverage, or results in changes to its insurance policies (including premium increases
or the imposition of large deductible or co-insurance requirements), could have an adverse effect on its business. In addition, Tvardi
cannot be sure that its existing insurance coverage will continue to be available on acceptable terms or that its insurers will not deny
coverage as to any future claim.

​

Changes in U.S. tax law could adversely affect Tvardi’s financial condition and results of operations.

The rules dealing with U.S. federal, state and local
income taxation are constantly under review by persons involved in the legislative process and by the U.S. Internal Revenue Service and
the U.S. Treasury Department. Changes to tax laws (which changes may have retroactive application) could adversely affect Tvardi or holders
of its common stock. In recent years, many such changes have been made and changes are likely to continue to occur in the future. Future
changes in U.S. tax laws could have a material adverse effect on its business, cash flow, financial condition or results of operations.
Tvardi urges investors to consult with their legal and tax advisors regarding the implications of potential changes in U.S. tax laws on
an investment in its common stock.

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If Tvardi’s information technology systems or those third parties with whom it works or its data, are or were compromised, Tvardi could experience adverse consequences resulting from such compromise, including but not limited to regulatory investigations or actions; litigation; fines and penalties; disruptions of our business operations; reputational harm; loss of revenue or profits; and other adverse consequences.

Tvardi’s information
systems and those of its current and any future collaborators, contractors, consultants, and other third parties with whom it works (i.e.,
its supply chain) are vulnerable to a variety of evolving threats, including but not limited to malware (including as a result of advanced
persistent threat intrusions), denial-of-service attacks, credential stuffing attacks