Company: SPRB
Filing Date: 2025-10-29
Form Type: S-3
Source: 0001193125-25-256662
Chunk: 42

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-10-29
Form: S-3
Chunk 42
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ated bylaws provide that we will indemnify our directors and officers and permit us to indemnify our employees and other agents, in each case to the maximum extent permitted by the Delaware General Corporation Law. We have entered into indemnification agreements with our directors and officers, whereby we have agreed to indemnify our directors and officers to the fullest extent permitted by law, including indemnification against expenses and liabilities incurred in legal proceedings to which the director or officer was, or is threatened to be made, a party by reason of the fact that such director or officer is or was a director, officer, employee, or agent of Spruce Biosciences, Inc., provided that such director or officer acted in good faith and in a manner that the director or officer reasonably believed to be in, or not opposed to, the best interest of Spruce Biosciences, Inc. At present, there is no pending litigation or proceeding involving a director or officer of Spruce Biosciences, Inc. regarding which indemnification is sought, nor is the registrant aware of any threatened litigation that may result in claims for indemnification. We maintain insurance policies that indemnify our directors and officers against various liabilities arising under the Securities Act and the Exchange Act that might be incurred by any director or officer in his capacity as such.

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Item 16. Exhibits

|         |     |                                                                                        |      | Incorporated by Reference |         |                  |
| Exhibit 
 Number  |     | Description of Document                                                                | Form | File No.                  | Exhibit | Filing Date      |
| 1.1*    |     | Form of Underwriting Agreement.                                                        |      |                           |         |                  |
| 3.1     |     | Amended and Restated Certificate of Incorporation of the Registrant.                   | 8-K  | 001-39594                 |     3.1 | October 14, 2020 |
| 3.2     |     | Certificate of Amendment to Amended and Restated Certificate of Incorporation          | 8-K  | 001-39594                 |     3.1 | July 24, 2025    |
| 3.3     |     | Amended and Restated Bylaws of the Registrant.                                         | 8-K  | 001-39594                 |     3.2 | October 14, 2020 |
| 4.1     |     | Form of Am