Company: PSTV
Filing Date: 2025-04-23
Form Type: S-3/A
Source: 0001193125-25-091456
Chunk: 0

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-23
Form: S-3/A
Chunk 0
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As filed with the Securities and Exchange Commission on April 23, 2025 Registration No. 333-286393 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 PLUS THERAPEUTICS, INC. (Exact name of registrant as specified in its charter)

| Delaware                        |     | 33-0827593            |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -I.R.S. Employer      
 Identification Number |

2710 Reed Road, Suite 160 Houston, Texas 77051 (737) 255-7194 (Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices) Marc H. Hedrick, M.D. President and Chief Executive Officer Plus Therapeutics, Inc. 2710 Reed Road, Suite 160 Houston, Texas 77051 (737) 255-7194 (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies to: Andrew L. Strong William I. Intner Hogan Lovells US LLP 609 Main Street, Suite 4200 Houston, Texas 77002 (713) 632-1400 Approximate Date of Commencement of Proposed Sale to the Public:From time to time after the effective date of this registration statement. If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: ☐ If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box: ☒ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become