Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063899
Chunk: 136

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 136
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 CogniMIR® or any other products it may develop on a timely basis, or at all.

It takes significant time
to fully develop and commercialize CogniMIR for risk of early neurodegeneration, and therefore its launch may be delayed
or may not be successful. There can be no assurance that CogniMIR will be successful in the risk assessment of Mild Cognitive
Impairment and early Alzheimer’s disease for a variety of technical and market reasons. DiamiR’s other molecular diagnostic
products, which are currently in various stages of early development, will take time to develop and commercialize, if DiamiR is able to
commercialize them at all. Prior to commercializing any new products, DiamiR will need to conduct substantial research and development,
including validation studies. DiamiR’s product development efforts involve a high degree of risk and may fail for many reasons,
including failure to demonstrate the clinical utility of the product. As DiamiR develops products, DiamiR will have to make significant
investments in product development and marketing resources. In addition, competitors may develop and commercialize competing products
faster than DiamiR is able to do so. If DiamiR is unable to commercialize CogniMIR, DiamiR may not be able to carry out
its business.

DiamiR relies on a sole supplier for some of the materials used in its tests and services, and DiamiR may not be able to find replacements or transition to alternative suppliers in a timely manner.

DiamiR relies on different
sole suppliers for certain materials, kits and supplies that DiamiR uses to perform its tests and services for its diagnostic tests. For
example, DiamiR relies on Qiagen Gmbh for its qPCR reagents and plates. DiamiR does not maintain an agreement with Qiagen Gmbh; their
reagents are readily available for purchase, additionally, the volume of DiamiR’s business is not material to them. In addition
to Qiagen, DiamiR works with other multinational stable corporations for its supplies. Although DiamiR does not currently have any agreements
with other suppliers and technologies, DiamiR believes other providers, such as ThermoFisher, which offers the TaqMan qPCR kits are easily
accessible and DiamiR can quickly begin working with them, if necessary. At the time of this filing all other reagents DiamiR uses are
commonly available through multiple vendors