Company: APM
Filing Date: 2025-01-03
Form Type: 424B5
Source: 0001213900-25-000606
Chunk: 0

Company: Aptorum Group Ltd
Filing Date: 2025-01-03
Form: 424B5
Chunk 0
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Filed pursuant to Rule 424(b)(5)

Registration No. 333-268873

<div align='center'>1,535,000 Class A Ordinary Shares

APTORUM GROUP LIMITED</div>

This is an offering of the securities of Aptorum Group Limited (the “Company”, “we”, “our”, “us”, “APM”), a Cayman Islands
exempted company with limited liability.

This prospectus supplement and the accompanying
base prospectus relates to an offering of an aggregate of 1,535,000 Class A Ordinary Shares (the “Shares”) of the Company,
par value $0.00001 per share (the “Class A Ordinary Shares”), pursuant to a Securities Purchase Agreement (the “Securities
Purchase Agreement”), dated as of January 2, 2025, between the Company and the purchasers identified on the signature pages thereto.
The purchase price of each Share is $2.00.

We have retained Maxim Group LLC (the “Placement
Agent” or “Maxim”) as our placement agent to use its “reasonable best efforts” to solicit offers to purchase
our shares in this offering. The Placement Agent has no obligation to buy any of the securities from us or to arrange for the purchase
or sale of any specific number or dollar amount of securities.

We will pay all of the expense’s incident
to the registration, offering and sale of the Shares under this prospectus supplement and the accompanying base prospectus.

Our Class A Ordinary Shares are listed on The
Nasdaq Capital Market, or Nasdaq, under the symbol “APM” On December 31, 2024, the last reported sale price of our Class A
Ordinary Shares on Nasdaq was US$2.80 per share.

The aggregate market value of our outstanding
Class A Ordinary Shares held by non-affiliates, or public float, as of December 31, 2024, was approximately US$9.67 million, which was
calculated based on 3,452,747 Class A Ordinary Shares held by non-affiliates as of December 31, 2024, and a per share price of US$2.80,
which was the closing price of our Class A Ordinary Shares on Nasdaq on December 31, 2024. Pursuant to General Instruction I.B.5 of Form
F-3, in no event will we sell the securities covered hereby in a public primary offering with a value exceeding more than one-third of
the