Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 20

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 20
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 became a wholly owned
subsidiary of Vickers. The Merger was approved by Vickers’s shareholders at a meeting held on November 9, 2022. In connection with the Scilex Business Combination, Vickers changed its name to “Scilex Holding Company.”

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In accordance with the terms and subject to the conditions of the Merger Agreement, at the
time at which the Scilex Business Combination became effective (the “Effective Time”), (i) each outstanding share of Legacy Scilex Common Stock outstanding immediately prior to the Effective Time was automatically cancelled in
exchange for the right to receive 0.673498 shares of our Common Stock, (ii) each share of Legacy Scilex Preferred Stock outstanding immediately prior to the Effective Time was cancelled in exchange for the right to receive (a) one
share of Series A Preferred Stock (as defined below) and (b) one-tenth of one share of our Common Stock, and (iii) each option to purchase shares of Legacy Scilex Common Stock outstanding as of
immediately prior to the Effective Time was converted into the right to receive a comparable option to purchase shares of our Common Stock.

Our Common Stock and Public Warrants are currently listed on the Nasdaq Capital Market under the symbols “SCLX” and
“SCLXW,” respectively.

The rights of holders of our Common Stock and Warrants (as defined below) are governed by the
Certificate of Incorporation, the Bylaws and the DGCL, and, in the case of the Warrants, the Warrant Agreement (the “Warrant Agreement”), dated January 6, 2021, between Vickers and Continental Stock Transfer & Trust Co.
(“Continental”). See sections of this prospectus titled “Description of Our Securities” and “Certain Relationships and Related Party Transactions.”

Recent Developments

Datavault Investment

On September 25, 2025, we entered into a Securities Purchase Agreement (the “Datavault SPA”) with Datavault AI
Inc., a Delaware corporation (“Datavault”), pursuant to which Datavault agreed to issue and sell, and we agreed to purchase, 15.0 million shares (the “Datavault Shares”) of common stock of Datavault (“Datavault
Common Stock”) in the initial closing which occurred on September 26, 2025 (the “Initial Datavault Closing”) and a pre-funded warrant (the “Datavault
Pre-Funded