Company: NOTV
Filing Date: 2025-01-10
Form Type: 424B7
Source: 0001628280-25-001122
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Company: Inotiv, Inc.
Filing Date: 2025-01-10
Form: 424B7
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#### Filed Pursuant to Rule 424(b)(7)

#### Registration No. 333-282491

#### PROSPECTUS SUPPLEMENT
(To Prospectus dated October 15, 2024)

#### 4,146,250 Common Shares

#### Offered by the Selling Shareholders
This prospectus supplement supplements the prospectus dated October 15, 2024 included in the Registration Statement on Form S-3 (No. 333-282491) that we filed with the Securities and Exchange Commission covering the resale by the selling shareholders named in the prospectus of 4,146,250 of our common shares issued or issuable upon the exercise of certain Warrant Certificates with an exercise price of $1.57 per share (the “Warrants”).

The purpose of this prospectus supplement is solely to supplement and update the “Selling Shareholders” table on page 9 of the prospectus to reflect the transfer of Warrants from certain selling shareholders previously identified in the prospectus to another selling shareholder previously identified in the prospectus for no consideration.

This prospectus supplement is not complete without, and may not be utilized except in connection with, the prospectus, including any amendments or supplements thereto. This prospectus supplement is qualified by reference to the prospectus, except to the extent that the information provided by this prospectus supplement supersedes information contained in the prospectus.

Our common shares are traded on The Nasdaq Capital Market under the symbol “NOTV.” On January 8, 2025, the last reported sale price of our common shares was $4.53 per share.

#### Investing in our securities involves risks. See “

#### Risk Factors

#### ” on page

#### 4
of the prospectus for a discussion of information that should be considered in connection with an investment in our securities.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus supplement is January 10, 2025</div>

### SELLING SHAREHOLDERS
The following information is provided to update the “Selling Shareholders” table in the prospectus to reflect the transfer of Warrants from selling shareholders previously named in the prospectus to selling shareholder Jermyn Street Capital LLC (“Jermyn Street”) for no consideration, as follows:

• Warrants to