Company: SFNC
Filing Date: 2025-07-23
Form Type: 424B5
Source: 0001193125-25-162761
Chunk: 48

Company: SIMMONS FIRST NATIONAL CORP
Filing Date: 2025-07-23
Form: 424B5
Chunk 48
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 been audited by FORVIS, LLP, an independent registered public
accounting firm, as set forth in its reports included therein, which are incorporated herein by reference. Such consolidated financial statements are incorporated herein by reference in reliance upon such reports given on the authority of such firm
as experts in auditing and accounting.

With respect to the unaudited interim consolidated financial information of the Company appearing
in our Quarterly Report on Form 10-Q for the period ended March 31, 2024, which is incorporated herein by reference, FORVIS, LLP has applied limited procedures in accordance with professional standards
for review of such information. However, as stated in its separate report included therein, FORVIS, LLP did not audit and it does not express an opinion on that interim financial information. Because of the limited nature of the review procedures
applied, the degree of reliance on its reports on such information should be restricted. Pursuant to Rule 436(c) under the Securities Act, this report on the Company’s unaudited interim consolidated financial information should not be
considered a part of the registration statement prepared or certified by its independent registered public accounting firm within the meaning of Sections 7 and 11 of the Securities Act.

4

16,220,000 Shares Simmons First National Corporation Class A Common Stock Prospectus Supplement July 21, 2025 Joint Book-Running Managers

| Stephens Inc. |     | Keefe, Bruyette & Woods 
 A Stifel Company        |     | Morgan Stanley |

Co-Managers

| Baird |     | Raymond James |