Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 2

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 2
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 Share          |         |    |     | Total |                |
|:--------------------------|:----|:---------------|--------:|---:|:----|:------|---------------:|
| Public offering price(1)  |     | $              | 25.0000 |    |     | $     | 400,000,000.00 |
| Underwriting discount(2)  |     | $              |  0.3736 | -3 |     | $     |   5,978,000.00 |
| Proceeds, before expenses |     | $              | 24.6264 | -3 |     | $     | 394,022,000.00 |

| (1) | The public offering price does not include dividends, if any, that may be declared. Dividends, if declared, will 
 be calculated from the date of initial issuance, which is expected to be August 11, 2025.                        |

| (2) | Reflects 12,320,000 depositary shares sold to institutional investors, for which the underwriters receive an                                                                                                  
 underwriting discount of $0.2500 per depositary share, and 3,680,000 depositary shares sold to retail investors, for which the underwriters receive an underwriting discount of $0.7875 per depositary share. |

| (3) | Rounded to four decimal places. See footnote (2). |

The underwriters expect to deliver the depositary shares to purchasers in book-entry form through the facilities of The Depository Trust Company (“DTC”) and its direct participants, including Euroclear Bank SA/NV (“Euroclear”) and Clearstream Banking, S.A. (“Clearstream”) on or about August 11, 2025. Joint Book-Running Managers

| Morgan Stanley |     | BofA Securities |     | J.P. Morgan |     | RBC Capital Markets |

Co-Managers

| Comerica Securities |     | Citigroup |     | Keefe, Bruyette & Woods 
 A Stifel Company        |

The date of this prospectus supplement is August 4, 2025

You should rely only on the information contained or incorporated by reference in this prospectus supplement, the accompanying prospectus or any free writing prospectus we have authorized. We have not, and the underwriters have not, authorized anyone to provide you with information that is different. We are not, and the under