Company: LEU
Filing Date: 2025-11-06
Form Type: 424B5
Source: 0001104659-25-107429
Chunk: 0

Company: CENTRUS ENERGY CORP
Filing Date: 2025-11-06
Form: 424B5
Chunk 0
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Filed Pursuant to Rule 424(b)(5)
Registration No. 333-291305

PROSPECTUS SUPPLEMENT
(to the Prospectus dated November 6, 2025)

<div align='center'>Up to $1,000,000,000

Centrus Energy Corp.

Class A Common Stock</div>

In accordance with the terms
of the Sales Agreement entered into with Barclays Capital Inc., Citigroup Global Markets Inc., UBS Securities LLC, Evercore Group L.L.C.,
B. Riley Securities, Inc., Guggenheim Securities, LLC, MUFG Securities Americas Inc., William Blair & Company, L.L.C.,
Lake Street Capital Markets, LLC and Northland Securities, Inc., as sales agents (each, an “Agent” and, together, the
“Agents”), dated November 6, 2025, which we refer to as the Sales Agreement, we may offer and sell under this prospectus
supplement shares of our Class A Common Stock, $0.10 par value per share (the “Class A Common Stock”), having an
aggregate offering price of up to $1,000,000,000, from time to time, through or to the Agents, acting as sales agents or principals.
In connection with the entry into the Sales Agreement, we terminated our “at the market offering” program pursuant to our
prior sales agreement, dated as of February 9, 2024.

Our Class A Common
Stock is traded on the NYSE American LLC (the “NYSE”) under the symbol “LEU.” The last reported sale price of
our Class A Common Stock on November 5, 2025 was $325.73 per share.

The shares of Class A
Common Stock offered under this prospectus supplement, if any, may be sold in ordinary brokers’ transactions on the NYSE or otherwise,
at market prices prevailing at the time of sale, in block transactions, in negotiated transactions, in any manner permitted by applicable
law or as otherwise agreed with the Agents. Under the terms of the Sales Agreement, we may also sell our Class A Common Stock to
an Agent as principal for its own account at a price agreed upon at the time of sale. If we sell shares of our Class A Common Stock
to any Agent as principal, we will enter into a separate terms agreement with the Agent, setting forth the terms of such transaction,
and we will describe the agreement in a separate prospectus supplement or pricing supplement. The Agents are not required to sell