Company: RVRC
Filing Date: 2025-10-03
Form Type: S-1/A
Source: 0001213900-25-096094
Chunk: 91

Company: Revium Rx.
Filing Date: 2025-10-03
Form: S-1/A
Chunk 91
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who.int/publications/i/item/9789240093461 |

| 6. | Cern A, Connolly KL, Jerse AE, Barenholz Y. In Vitro Susceptibility of Neisseria gonorrhoeae Strains to Mupirocin, an Antibiotic Reformulated for Parenteral Administration in Nanoliposomes. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02377-17. https://doi.org/10.1128/aac.02377-17 |

| 7. | O.                                                                                                                                
 Goldmann, A. Cern, M. Muesken, et al., Liposomal mupirocin holds promise for systemic treatment of invasive Staphylococcus aureus 
 infections, Journal of Controlled Release (2019), https://doi.org/10.1016/j.jconrel.2019.11.007                                   |

<div align='center'>57</div>

IP protection.

Several patents and licenses for Nano-Mupirocin
were already obtained in major countries and regions, including the U.S., Europe (in the table referred to as European Patent Office –
EP), Japan, India and China.

Pursuant to the Yissum License Agreements,
we have an exclusive, worldwide license for the development, use, manufacture and commercialization of products arising out of patents
owned by, and patent applications filed by, Yissum in connection with Liposomal formulation of Nano-Mupirocin. All of patents and patent
applications listed below were licensed to us by Yissum pursuant to the Yissum License Agreements.

All below patents are composition of matter patents.

| Status  
 Granted 
 Granted 
 Granted |     | Country 
 US      
 EP      
 EP-BE   |     | Application   
 Date          
 Oct. 10, 2016 
 Oct. 11, 2016 
 Oct. 11, 2016 |     | Title (with         
 embodiment          
 where applicable)   
 Liposomal Mupirocin 
 Liposomal Mupirocin 
 Liposomal Mupirocin |     |  Publication 
       Number 
 2017/0027869 
      3142642 
      3142642 |     | Patent Date       
 June 26, 2018     
 August 29, 2018   
 August 29, 2018   |     |   Patent Number 
      10,004,688 
         314