Company: BCDRF
Filing Date: 2025-01-08
Form Type: 424B5
Source: 0001193125-25-003514
Chunk: 3

Company: Banco Santander, S.A.
Filing Date: 2025-01-08
Form: 424B5
Chunk 3
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 | % |
| Total 2035 Fixed Rate Notes |     | $               | 1,000,000,000 |   |     | $            | 4,500,000 |   |     | $                 |   995,500,000 |   |
| Total                       |     | $               | 2,000,000,000 |   |     | $            | 7,500,000 |   |     | $                 | 1,992,500,000 |   |

The initial public offering prices set forth above do not include accrued interest, if any. Interest on the Notes will accrue from the expected date of issuance, which is January 17, 2025. See “ Underwriting (Conflicts of Interest).” We expect that the Notes will be ready for delivery through the book-entry facilities of The Depository Trust Company (“DTC”) and its direct and indirect participants, including Clearstream Banking, société anonyme(“Clearstream Luxembourg”) and Euroclear Bank SA/NV (“Euroclear”) on or about January 17, 2025, which will be the eighth New York business day following the pricing of the Notes (such settlement period being referred to as “T+8”). Beneficial interests in the Notes will be shown on, and transfers thereof will be effected only through, records maintained by DTC and its participants. Joint Bookrunners

| BofA Securities |     | Citigroup |     | Credit Agricole CIB |     | Goldman Sachs Bank Europe SE |

| Morgan Stanley |     | RBC Capital Markets |     | Santander |     | Wells Fargo Securities |

Co-Leads

| Banco Sabadell |     | Bankinter S.A. |     | CIBC Capital 
 Markets      |     | Independence     
 Point Securities |     | Rabo Securities |

Prospectus Supplement dated January 7, 2025

TABLE OF CONTENTS Prospectus Supplement

|                                           |     | Page |      |
| Notice to Investors                       |     |      | S-i  |
| About this Prospectus Supplement          |     |      | S-iv |
| Incorporation of Information by Reference |     |      | S-iv |
| Forward-Looking Statements                |     |      | S-v  |
| Important Information                     |     |      | S-v  |
| Summary                                   |     |      | S-1  |
| Risk Factors                              |     |      | S-13 |
| Use