Company: SHPH
Filing Date: 2025-12-11
Form Type: S-1/A
Source: 0001493152-25-027310
Chunk: 11

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-12-11
Form: S-1/A
Chunk 11
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5) Includes 758,953 (prior to this filing) shares issuable upon exercise of a pre-funded warrant. The pre-funded warrant cannot be exercised to the extent such exercise would result in the holder beneficially owning more than 4.99% of the Company’s common stock. The ownership amount in the table does not give effect to such beneficial ownership limitation.

(6) Includes 625,156 shares issuable upon exercise of a pre-funded warrant. The pre-funded warrant cannot be exercised to the extent such exercise would result in the holder beneficially owning more than 4.99% of the Company’s common stock. The ownership amount in the table does not give effect to such beneficial ownership limitation.

Material Relationships with Selling Stockholder

June 2025 Private Placement

On June 20, 2025, we entered into a securities purchase agreement with the selling stockholder (the “June 2025 Purchase Agreement”), for the sale by the Company to the selling stockholder, in a private placement, of 21,924 shares of common stock of the Company and 1,158,953 pre-funded warrants, each to purchase one share of common stock of the Company at a purchase price of $3.599 and exercise price of $0.001 per pre-funded warrant (the “June 2025 Private Placement”). The June 2025 Private Placement closed on June 24, 2025 and we received gross proceeds of approximately $4.3 million before deducting fees and other offering expenses payable by us.

Other than the transactions described above and in “The Private Placement,” we have had no material relationships with the selling stockholder in the last three (3) years.

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<div align='center'>PLAN OF DISTRIBUTION</div>

The selling stockholder and any of its pledgees, assignees and successors-in-interest may, from time to time, sell any or all of its securities covered hereby on the Nasdaq Capital Market or any other stock exchange, market or trading facility on which the securities are traded or in private transactions. These sales may be at fixed or negotiated prices. The selling stockholder may use any one or more of the following methods when selling securities:

| ● | ordinary                                                                                                                                  
 brokerage transactions and transactions in which the broker-dealer solicits purchasers;                                                   |
| ● | block                                                                                                                                     
 trades in which the broker-dealer will attempt to sell the securities as agent but may position and resell a portion of the block         
 as principal to facilitate the transaction;                                                                                               |