Company: NCNA
Filing Date: 2025-04-24
Form Type: F-1
Source: 0001193125-25-092131
Chunk: 94

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-1
Chunk 94
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| • |     | this summary: (a) only addresses the principal U.K. tax consequences for investors who hold the ADSs as 
 capital assets, (b) does not address the tax consequences that may be relevant to certain special       |

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| classes of investor such as dealers, brokers or traders in shares or securities and other persons who hold the ADSs, Warrants and/or Pre-Funded Warrants                                                                                                                                                                                                                                                                 
 otherwise than as an investment, (c) does not address the tax consequences for holders that are financial institutions, insurance companies, collective investment schemes, pension schemes, charities or                                                                                                                                                                                                                
 tax-exempt organizations, (d) assumes that the holder is not an officer or employee of the company (or of any related company) and has not (and is not deemed to have) acquired the ADSs, Warrants and/or Pre-Funded Warrants or related ordinary shares by virtue of an office or employment, and (e) assumes that the holder does not control or hold (and is not deemed to control or hold), either alone or together 
 with one or more associated or connected persons, directly or indirectly (including through the holding of the related ordinary shares or ADSs, Warrants and/or Pre-Funded Warrants), an interest of 10% or more in the issued share capital (or in any                                                                                                                                                                  
 class thereof or ADSs), voting power, rights to profits or capital of the company, and is not otherwise connected with the company.                                                                                                                                                                                                                                                                                      |

This summary further assumes, on the basis of HMRC guidance, that a holder of ADSs will be regarded by HMRC as the beneficial owner of the underlying ordinary shares and of any dividends paid in respect of the related ordinary shares (where the dividends are regarded for U.K. tax purposes as that person’s own income (and not the income of some other person)) for U.K. tax purposes. Potential investors in ADSs, Warrants and/or Pre-FundedWarrants should satisfy themselves prior to investing as to the overall tax consequences, including, specifically, the consequences under U.K. tax law and HMRC practice of the acquisition, ownership and disposal of ADSs, Warrants and/or Pre-FundedWarrants in their own particular circumstances by consulting their own tax advisers. In particular, non-U.K.resident persons are advised to consider the potential impact of any relevant double taxation agreements. Taxation of dividends Withholding Tax.Dividend payments in respect of ADSs or ordinary shares may be made without withholding or deduction