Company: ZURA
Filing Date: 2025-11-13
Form Type: 10-Q
Source: 0001104659-25-110793
Chunk: 30

Company: Zura Bio Ltd
Filing Date: 2025-11-13
Form: 10-Q
Item: Part I, Item 8
Chunk 30
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Notes to Unaudited Condensed Consolidated Financial Statements

1.Organization and Description of BusinessZura Bio Limited, a Cayman Islands exempted company, formerly known as JATT Acquisition Corp (“JATT”), together with its subsidiaries (collectively, the “Company” or “Zura”), is a clinical-stage, multi-asset immunology company dedicated to developing novel dual-pathway antibodies for a range of autoimmune and inflammatory diseases with unmet needs.The Company’s strategic focus is to leverage dual-pathway biology to develop therapies intended to provide broader and deeper clinical benefits for patients with immune-mediated conditions. The Company currently has one clinical-stage product candidate in ongoing Phase 2 trials and is continuing to evaluate additional development opportunities within its pipeline, focusing on indications with unmet need and commercial potential.The Company’s lead product candidate, tibulizumab (ZB-106), is an immunoglobulin G (“IgG”)-single-chain variable fragment (“scFv”) bispecific dual-antagonist antibody engineered by the fusion of TALTZ® (ixekizumab) and tabalumab to neutralize interleukin-17A (IL-17A) and B-cell activating factor (BAFF).●In May 2025, the Company initiated TibuSHIELD, a global randomized, double-blind, placebo-controlled Phase 2 clinical study evaluating tibulizumab in approximately 180 adults with moderate to severe hidradenitis suppurativa (HS). The trial is designed to assess the safety, tolerability, and efficacy of tibulizumab for the treatment of HS in this patient population.●In December 2024, the Company initiated TibuSURE, a global randomized, double-blind, placebo-controlled Phase 2 study evaluating tibulizumab in approximately 80 adults with early diffuse cutaneous systemic sclerosis (dcSSc). The trial is designed to assess the safety, tolerability, and efficacy of tibulizumab for the treatment of dcSSc in this patient population.Additionally, the Company is actively assessing the competitive landscape and evaluating potential therapeutic indications for crebankitug and torudokimab.●Crebankitug (ZB-168) is a fully human, high affinity monoclonal antibody that binds and neutralizes the interleukin-7 receptor (IL-7R) alpha chain. IL-7Rα sits at the nexus of two key immune pathways, IL-7 and thymic