Company: XXII
Filing Date: 2025-02-05
Form Type: S-3/A
Source: 0001493152-25-005039
Chunk: 20

Company: 22nd Century Group, Inc.
Filing Date: 2025-02-05
Form: S-3/A
Chunk 20
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 prospectus is a part of the registration statement, but does not contain all of the information included in the registration statement or the exhibits. You can find our public filings with the SEC on the internet at a web site maintained by the SEC located at http://www.sec.gov.

<div align='center'>Incorporation of Certain Documents by Reference</div>

We are “incorporating by reference” specified documents that we file with the SEC, which means:

| ● | incorporated                                      
 documents are considered part of this prospectus; |

| ● | we                                                                                   
 are disclosing important information to you by referring you to those documents; and |

| ● | information                                                                                            
 we file with the SEC will automatically update and supersede information contained in this prospectus. |

We incorporate by reference the documents listed below and any future filings we make with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (in each case, other than information furnished under Item 2.02 or Item 7.01 of Form 8-K) (i) after the date of the registration statement on Form S-3 filed under the Securities Act with respect to securities offered by this prospectus and prior to the effectiveness of such registration statement and (ii) after the date of this prospectus and before the end of the offering of the securities pursuant to this prospectus:

| 11 |

Information in this prospectus supersedes related information in the documents listed above, and information in subsequently filed documents supersedes related information in both this prospectus and the incorporated documents.

We will promptly provide, without charge to you, upon written or oral request, a copy of any or all of the documents incorporated by reference in this prospectus, other than exhibits to those documents, unless the exhibits are specifically incorporated by reference in those documents. Requests should be directed to:

<div align='center'>22nd Century Group, Inc.

321 Farmington Rd

Mocksville, NC 27028

(336) 940-3769</div>

You can also find these filings on our website at www.xxiicentury.com. We are not incorporating the information on our website other than these filings into this prospectus. You should rely only on the information contained in this prospectus (including information incorporated by reference therein) and any free writing prospectus that we may authorize to be delivered to you. We have not authorized anyone to provide you with different information. If anyone provides you with different or inconsistent