Company: BDRX
Filing Date: 2025-12-11
Form Type: F-1/A
Source: 0001214659-25-017944
Chunk: 0

Company: Biodexa Pharmaceuticals Plc
Filing Date: 2025-12-11
Form: F-1/A
Chunk 0
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<div align='center'>As filed with the U.S. Securities and Exchange Commission on December 11, 2025.</div>

Registration No. 333-291598

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

AMENDMENT NO. 2

TO

FORM F-1

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

Biodexa Pharmaceuticals PLC

(Exact name of registrant as specified in its charter)</div>

| England and Wales               |                         2834 | Not Applicable     |
| (State or Other Jurisdiction of 
 Incorporation or Organization)  | -Primary Standard Industrial 
   Classification Code Number | -IRS Employer      
 Identification No. |

<div align='center'>1 Caspian Point

Caspian Way

Cardiff, CF10 4DQ, United Kingdom

Tel: +44 29 20480 180

(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

Donald J. Puglisi

Puglisi & Associates

850 Library Ave., Suite 204

Newark, Delaware 19711

Tel: ( 302) 738-6680

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copies of communications to:</div>

| Jason S. McCaffrey                                | Faith L. Charles               |
| Mintz, Levin, Cohn, Ferris, Glovsky & Popeo, P.C. | Thompson Hine LLP              |
| One Financial Center                              | 300 Madison Avenue, 27th Floor |
| Boston, Massachusetts 02111                       | New York, New York 10017       |
| Telephone: (617) 542-6000                         | Telephone: (212) 908-3905      |
| Facsimile: (617) 542-2241                         |                                |

Approximate date of commencement of proposed sale to the public: As soon as practicable after the effective date of this Registration Statement.

If any of the securities being registered on this
Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. x

If this Form is filed to register additional securities
for an offering pursuant to Rule 462(b) under the