Company: OSRH
Filing Date: 2025-06-27
Form Type: 424B3
Source: 0001213900-25-058551
Chunk: 2

Company: OSR Holdings, Inc.
Filing Date: 2025-06-27
Form: 424B3
Chunk 2
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 Factors” beginning on page 17 of the Prospectus for a discussion of certain risks that you should consider in connection with an investment in our securities.

<div align='center'>The date of this prospectus is June 26, 2025.

EXPLANATORY NOTE</div>

This prospectus supplement is being filed to update,
amend and supplement the information included in the Prospectus to reflect the initial issuance of shares by the Company pursuant to the
ELOC Agreement and the related issuance of commitment shares, as set forth below.

On June 17, 2025, the Company issued 519,481 shares
of common stock to White Lion as commitment shares under the ELOC Agreement. The number of shares was determined based on the closing
price of the Company’s common stock on June 17, 2025, which was $1.5400 per share.

On June 20, 2025, the Company issued and sold
5,000 shares of its common stock to White Lion, pursuant to the terms of the ELOC Agreement dated May 6, 2025, at a purchase price of
$1.5200 per share, resulting in gross proceeds of $7,600.00 to the Company.

On June 24, 2025, the Company issued and sold
5,000 shares of its common stock to White Lion pursuant to a volume-weighted average price (“VWAP”) purchase notice under
the ELOC Agreement, at a purchase price of $1.2901 per share, resulting in gross proceeds of $6,450.50 to the Company.