Company: SPRB
Filing Date: 2025-03-31
Form Type: NT 10-K
Source: 0000950170-25-047912
Chunk: 3

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-03-31
Form: NT 10-K
Chunk 3
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 not to put undue reliance on forward-looking statements, and the Company assumes no obligation and does not intend to update or revise these forward-looking statements, except as required by applicable law.

<div align='center'>Spruce Biosciences, Inc.

(Name of Registrant as Specified in Charter)</div>

has caused this notification to be signed on its behalf by the undersigned hereunto duly authorized.

| Date: |     | March 31, 2025 |     | By |     | /s/ Javier Szwarcberg, M.D., MPH                    |
|:------|:----|:---------------|:----|:---|:----|:----------------------------------------------------|
|       |     |                |     |    |     | Javier Szwarcberg, M.D., MPHChief Executive Officer |