Company: SCLXW
Filing Date: 2025-02-26
Form Type: PRER14A
Source: 0001193125-25-036730
Chunk: 1

Company: Scilex Holding Co
Filing Date: 2025-02-26
Form: PRER14A
Chunk 1
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. Pacific Time via live audio webcast on the Internet at www.virtualshareholdermeeting.com/SCLX2025SMfor the following purposes, as more fully described in the accompanying proxy statement for the Special Meeting (the “Proxy Statement”):

| 1. | To approve any amendment to the Company’s Restated Certificate of Incorporation to effect a reverse                                                                                                                                   
 stock split of the Company’s common stock, $0.0001 par value per share (the “Common Stock”), within a range of 1-for-14 to                                                                                                            
 1-for-50 (or any number in between), without reducing the authorized number of shares of the Common Stock, and the filing of a final amendment with the ratio within such                                                             
 range to be determined in the sole discretion of the Board of Directors of the Company (the “Board”) at any time on or before March 19, 2026, without further approval or authorization of our stockholders (the “Reverse Stock Split 
 Proposal”); and                                                                                                                                                                                                                       |

| 2. | To consider and vote upon an adjournment of the Special Meeting, if necessary, to solicit additional proxies 
 if there are not sufficient votes in favor of the Reverse Stock Split Proposal.                              |

In order to provide expanded access to our stockholders, the Board has determined to hold a live audio webcast in lieu of an in-personmeeting. You will be able to vote and submit your questions during the meeting at www.virtualshareholdermeeting.com/SCLX2025SM. The virtual-only approach also lowers costs and aligns with our broader sustainability goals. Although no physical in-personmeeting will be held, we designed the format of the Special Meeting to ensure that our stockholders of record who attend the Special Meeting will be afforded similar rights and opportunities to participate as they would at an in-personmeeting. As always, we encourage you to vote your shares prior to the Special Meeting either by Internet or by proxy card to help make this meeting format as efficient as possible. The Board has fixed the close of business on February 24, 2025 as the record date for the Special Meeting. Only stockholders of record on February 24, 2025 are entitled to notice of and to vote at the Special Meeting. Further information regarding voting rights and the matters to be voted upon is presented in the Proxy Statement. We intend to mail the Proxy Statement and the accompanying proxy card on or about , 2025 to all stockholders of record entitled to vote at the Special Meeting. YOUR V