Company: TEM
Filing Date: 2025-08-27
Form Type: 424B7
Source: 0001193125-25-189854
Chunk: 0

Company: Tempus AI, Inc.
Filing Date: 2025-08-27
Form: 424B7
Chunk 0
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Filed Pursuant to Rule 424(b)(7)
Registration No. 333-289398

Prospectus Supplement

1,268,033 SHARES OF CLASS A COMMON STOCK

This prospectus supplement relates to the resale from time to time of up to 1,268,033 shares of Class A common stock, par value $0.0001 per share, of
Tempus AI, Inc., a Nevada corporation (“Tempus,” “we,” “us” or “our”), by the selling stockholders referenced in this prospectus supplement.

1,124,714 shares of Class A common stock being registered were issued pursuant to or in connection with the Agreement and Plan of Merger, dated
August 22, 2025 (the “Merger Agreement”), by and among Tempus, Giant Panda Merger Sub, Inc., a Delaware corporation and a direct, wholly owned subsidiary of Tempus, Paige.AI, Inc., a Delaware corporation (“Paige.AI”),
and Shareholder Representative Services LLC, a Colorado limited liability company, solely in its capacity as the securityholder representative, relating to our acquisition of Paige.AI, which includes 85,966 shares of Class A common stock that
may be released to certain selling stockholders in connection with the release of a holdback pursuant to the terms of the Merger Agreement. 17,915 shares of Class A common stock being registered were issued pursuant to the License Agreement,
dated August 22, 2025 (the “License Agreement”), by and among Memorial Sloan-Kettering Cancer Center, Memorial Hospital for Cancer and Allied Diseases, and Sloan-Kettering Institute for Cancer Research, each a New York not-for-profit corporation (collectively, “MSK”) and Tempus relating to Tempus’ license of certain intellectual property from MSK. 125,404 shares of
Class A common stock being registered were issued pursuant to the Settlement and Release Agreement, dated August 22, 2025 (the “Release Agreement”), by and among MSK, Paige.AI, and Tempus, relating to the mutual settlement and
release of certain claims by the parties thereto. See the section titled “Selling Stockholders” for more information.

We are registering the
resale of the shares of Class A common stock pursuant to requirements of certain agreements between us and the selling stockholders. See the section titled “Selling Stockholders” for additional information regarding the selling
stockholders and the requirements of certain agreements between us and the selling stockholders.

We are