Company: SCLXW
Filing Date: 2025-05-07
Form Type: POS AM
Source: 0001193125-25-115095
Chunk: 256

Company: Scilex Holding Co
Filing Date: 2025-05-07
Form: POS AM
Chunk 256
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 placebo), week, site, Pain Catastrophizing Scale group (<30 or ≥30), baseline score, and treatment-by-week interaction. |

| (3) | The analysis uses an ANCOVA model with fixed effects for treatment (SP-102 or placebo), site, Pain Catastrophizing Scale group (<30 or ≥30), and baseline score. |

ANCOVA: analysis of covariance; ANOVA: analysis of variance; BPI-SF:Brief Pain Inventory – Short Form; CI: confidence interval; ITT: intent-to-treat(randomized population); LSM: least-squares mean; MMRM: mixed model for repeated measures; NPRS: numeric pain rating scale; REML: restricted maximum likelihood; SE: standard error 164

Patient Global Impression of Change (PGIC) and Clinical Global Impression of Change (CGIC) – ITT Population

|                                                                                                   |     | SP-102 
 N=202  |            |     | Placebo 
 N=199   |            |   |
| PGIC Responders (number of patients who responded with “very much improved” or “much improved”(1) |     |        | 71 (35.1%) |     |         | 39 (19.6%) |   |
| Chi-Square                                                                                        |     |        |    P<0.001 |     |         |            |   |
| Logistic regression (odds ratio [95% CI])(2)                                                      |     |        |       2.25 |     |         | (1.42,3.54 | ) |
|                                                                                                   |     |        |    P<0.001 |     |         |            |   |
| CGIC Responders (number of patients assessed as “very much improved” or “much improved”(1)        |     |        | 76 (37.6%) |     |         | 39 (19.6%) |   |
| Chi-Square                                                                                        |     |        |    P<0.001 |     |         |            |   |
| Logistic regression (odds ratio [95% CI])(2)                                                      |     |        |       2.49 |     |         | -1.58,3.91 |   |
|                                                                                                   |     |        |    P<0.001 |     |         |            |   |

| (1) | 7-point scale rating patient’s overall improvement. Patient