Company: LENZ
Filing Date: 2025-04-14
Form Type: 424B5
Source: 0001628280-25-017695
Chunk: 1

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-14
Form: 424B5
Chunk 1
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”). See “ Plan of Distribution ” beginning on page S- 15 for additional information regarding the compensation to be paid to TD Cowen.

We are an “emerging growth company” and a “smaller reporting company” under federal securities laws and as such, have elected to comply with reduced public company reporting requirements for this prospectus supplement, the accompanying prospectus and the documents incorporated by reference herein and may elect to comply with reduced public company reporting requirements in future filings. See “Prospectus Supplement Summary—Implications of Being an Emerging Growth Company and Smaller Reporting Company.”

Our business and an investment in our common stock involve significant risks. Before making an investment decision, you should review carefully and consider all of the information set forth in this prospectus supplement and the documents incorporated by reference. These risks are described under the caption “ Risk Factors

#### ” beginning on page

#### S- 7
of this prospectus supplement and in the documents incorporated by reference into this prospectus supplement.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

| TD Cowen |

<div align='center'>The date of this prospectus supplement is April 14, 2025.</div>

### TABLE OF CONTENTS

#### Prospectus Supplement
|                                                   |     | Page |
| ABOUT THIS PROSPECTUS SUPPLEMENT                  |     | S-1  |
| MARKET, INDUSTRY AND OTHER DATA                   |     | S-2  |
| PROSPECTUS SUPPLEMENT SUMMARY                     |     | S-3  |
| THE OFFERING                                      |     | S-5  |
| RISK FACTORS                                      |     | S-7  |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     | S-9  |
| USE OF PROCEEDS                                   |     | S-11 |
| DIVIDEND POLICY                                   |     | S-12 |
| DILUTION                                          |     | S-13 |
| PLAN OF DISTRIBUTION                              |     | S-15 |
| LEGAL MATTERS                                     |     | S-16 |
| EXPERTS                                           |     | S-16 |
| WHERE YOU CAN FIND MORE INFORMATION               |     | S-17 |
| INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE   |     | S-17 |

#### Prospectus
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