Company: PSTV
Filing Date: 2025-04-11
Form Type: POS AM
Source: 0001193125-25-079109
Chunk: 4

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-11
Form: POS AM
Chunk 4
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-interest,except with respect to amounts received by us upon exercise of the Warrants, to the extent the Warrants are exercised for cash. We will bear all expenses of any offering of shares of common stock, except that the selling stockholders will pay any applicable underwriting fees, discounts or commissions and transfer taxes. Our common stock is listed on The Nasdaq Capital Market under the trading symbol “PSTV.” On April 10, 2025, the closing sale price of our common stock was $0.7871 per share. Investing in our shares of common stock involves a high degree of risk that are described in the section entitled “ Risk Factors” beginning on page 3 of this prospectus and under similar headings in the documents incorporated by reference into this prospectus. You should also review carefully any risk factors included in any applicable prospectus supplement for a discussion of additional risks that you should consider before investing in our common stock. Neither the SEC nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense. The date of this prospectus is , 2025.

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS                                |     |  ii |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS |     | iii |
| PROSPECTUS SUMMARY                                   |     |   1 |
| OUR COMPANY                                          |     |   1 |
| THE OFFERING                                         |     |   2 |
| RISK FACTORS                                         |     |   3 |
| USE OF PROCEEDS                                      |     |   4 |
| SELLING STOCKHOLDERS                                 |     |   5 |
| PLAN OF DISTRIBUTION                                 |     |  11 |
| LEGAL MATTERS                                        |     |  14 |
| EXPERTS                                              |     |  14 |
| WHERE YOU CAN FIND ADDITIONAL INFORMATION            |     |  14 |
| INFORMATION INCORPORATED BY REFERENCE                |     |  14 |

You should rely only on the information provided in this prospectus, as well as the information incorporated by reference to exhibits to the registration statement of which this prospectus forms a part and any applicable prospectus supplement or amendment. Neither we nor the selling stockholders have authorized anyone to provide you with different information. Neither we nor the selling stockholders are making an offer of these securities in any jurisdiction where the offer is not permitted. You