Company: PACB
Filing Date: 2025-01-10
Form Type: POSASR
Source: 0001299130-25-000004
Chunk: 0

Company: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
Filing Date: 2025-01-10
Form: POSASR
Chunk 0
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Post-Effective Amendment”) relates to the following Registration Statement on Form S-3 (the “Registration Statement”) filed with the Securities and Exchange Commission (the “Commission”) of Pacific Biosciences of California, Inc., a Delaware corporation (the “Company”), to deregister any and all securities, registered but unsold or otherwise unissued as of the date hereof under the Registration Statement:

• Registration No. 333-279269, filed with the Commission on May 9, 2024 , registering an aggregate of 10,551,721 shares of the Company’s common stock, par value $0.001 per share (“Common Stock”);

The Company is seeking to deregister all shares of Common Stock that remain unsold under the Registration Statement as of the date hereof because its obligation to maintain the effectiveness of the Registration Statement pursuant to the terms of the applicable agreements with the selling stockholder named in the Registration Statement have terminated. Accordingly, pursuant to the undertaking of the Company in the Registration Statement as required by Item 512(a)(3) of Regulation S-K, the Company is filing these Post-Effective Amendments to deregister, and does hereby remove from registration, all the securities of the Company registered under the Registration Statement that remain unsold as of the date hereof, if any.

### SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing this Post-Effective Amendment No. 1 to Form S-3 and has duly caused this Post-Effective Amendment No. 1 to Form S-3 to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Menlo Park, State of California, on January 10, 2025.

| Pacific Biosciences of California, Inc. |     |                               |
| By:                                     |     | /s/ Brett Atkins              |
|                                         |     | Brett Atkins                  |
|                                         |     | General Counsel and Secretary |

Note: No other person is required to sign this Post-Effective Amendment No. 1 to the Registration Statement in reliance on Rule 478 of the Securities Act of 1933, as amended.