Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063906
Chunk: 21

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 21
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R Primary Stockholder Parties (as defined below) and three (3) of whom has been designated by Aptorum. Effective as of the Effective Time, the Aptorum board of directors will appoint the following DiamiR designees: MBA, Kira Sheinerman, Ph.D., MBA., and [ ], and the following Aptorum designee: Ian Huen, Justin Wu, and Douglas Arner to the board of directors of the Combined Company and concurrently therewith. Ian Huen is expected to be appointed as Chair of the board of directors of the Combined Company. Alidad Mireskandari, Ph.D., MBA will be appointed as a non -votingobserver to the Board of the Combined Company. The current staggered structure of the Aptorum Board will adjust to a single class of directors for the Combined Company following the completion of the Merger. For additional information, please see the section titled “ Management Following the Merger”. vi

Q:Who will be the executive officers of the Combined Company immediately following the Merger? A:Immediately following the Merger, the executive management team of the Combined Company is expected to consist of members of the Aptorum and DiamiR executive management team prior to the Merger, including:

| Name                |     | Title                              |
| Ian Huen            |     | Chief Executive Officer            |
| Gary Anthony        |     | Chief Financial Officer            |
| Alidad Mireskandari |     | President, Chief Operation Officer |

Q:As an Aptorum shareholder, how does the Aptorum Board recommend that I vote? A:The Aptorum Board, in consultation with legal advisors and management, evaluated the terms of the Merger Agreement and the related transactions contemplated thereby and: (i) determined that the Merger and the related transactions contemplated by the Merger Agreement are fair to, advisable and in the best interests of Aptorum and its stockholders; (ii) approved and declared advisable the Merger Agreement and the related transactions contemplated by the Merger Agreement, including the issuance of shares of Aptorum common stock, in connection with the Merger, respectively; and (iii) recommends that Aptorum shareholders vote “FOR” each of Proposal Nos. 2 and 3. The Aptorum board of directors also recommends that Aptorum shareholders vote “FOR” Proposal Nos. 1 and 4. Q:What if another matter is properly brought before the Special Meeting? A:As of the date of filing this proxy statement/prospectus, the Aptorum