Company: SMNR
Filing Date: 2025-08-12
Form Type: S-4/A
Source: 0001193125-25-178821
Chunk: 963

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-08-12
Form: S-4/A
Chunk 963
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 constitute one agreement. This Agreement shall become effective upon delivery to each party of an executed counterpart or the earlier delivery to each party of original, photocopied, or electronically transmitted signature pages that together (but need not individually) bear the signatures (each of which may be an electronic signature, including pdf or any electronic signature complying with the U.S. federal ESIGN Act of 2000 or comparable Law e.g., www.docusign.com or www.HelloSign.com) of all other parties.

<div align='center'>[signature pages follow]

A-1-59</div>

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of the day and year first above written.

| Parent:                          |     |                                |
| DENALI CAPITAL ACQUISITION CORP. |     |                                |
| By:                              |     | /s/ Lei Huang                  |
|                                  |     | Name: Lei Huang                |
|                                  |     | Title: Chief Executive Officer |
| Merger Sub:                      |     |                                |
| DENALI MERGER SUB INC.           |     |                                |
| By:                              |     | /s/ Peter Xu                   |
|                                  |     | Name: Peter Xu                 |
|                                  |     | Title: President               |

[Signature Page to the Agreement and Plan of Merger] A-1-60

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of the day and year first above written.

| Company:                     |     |                                |
| SEMNUR PHARMACEUTICALS, INC. |     |                                |
| By:                          |     | /s/ Jaisim Shah                |
|                              |     | Name: Jaisim Shah              |
|                              |     | Title: Chief Executive Officer |

[Signature Page to the Agreement and Plan of Merger] A-1-61

**Annex A-2**

<div align='center'>**AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER**</div>

THIS AMENDMENT NO. 1 TO AGREEMENT AND PLAN OF MERGER (this “Amendment”), dated as of April 16, 2025, is made and entered into by and among Denali Capital Acquisition Corp., a Cayman Islands exempted company (which shall migrate to and domesticate as a Delaware corporation prior to the Closing, “Parent”), Denali Mer