Company: PFSA
Filing Date: 2025-10-09
Form Type: S-1
Source: 0001213900-25-097860
Chunk: 1

Company: Profusa, Inc.
Filing Date: 2025-10-09
Form: S-1
Chunk 1
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 an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer | ☐ |     | Accelerated filer         | ☐ |
| Non-accelerated filer   | ☒ |     | Smaller reporting company | ☒ |
|                         |   |     | Emerging growth company   | ☒ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐ This registration statement shall hereafter become effective in accordance with the provisions of Section 8(a) of the Securities Act of 1933. The information in this preliminary prospectus is not complete and may be changed. The selling stockholder may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This preliminary prospectus is not an offer to sell, nor does it seek an offer to buy these securities in any jurisdiction where the offer or sale is not permitted. SUBJECT TO COMPLETION, DATED october 8, 2025. PRELIMINARY PROSPECTUS PROFUSA, INC. 42,594,048 Shares of Common Stock This prospectus relates to the resale, from time to time, by the Selling Stockholders identified in this prospectus under the caption “Selling Stockholders,” of up to 42,594,048 shares of common stock, par value $0.0001 per share, of the Company (the “ Common Stock”) comprising: (a) up to 42,211,548 shares of Common Stock by Ascent Partners Fund LLC, whom we refer to in this prospectus as “Ascent,” pursuant to a common stock purchase agreement, dated as of July 28, 2025, we entered into with Ascent, which we refer to in this prospectus as the Purchase Agreement; and (b) up to 382,500 shares of Common Stock issued to certain parties in satisfaction of transaction costs incurred in connection with the Business Combination we completed on July 11, 2025. In our registration statement, filed on August 22, 2025 and