Company: TELO
Filing Date: 2025-02-04
Form Type: 10-K
Source: 0001493152-25-004872
Chunk: 279

Company: Telomir Pharmaceuticals, Inc.
Filing Date: 2025-02-04
Form: 10-K
Item: Item 1
Chunk 279
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 Telomir-1 represents
a potential breakthrough in diabetes treatment. A key indicator of its success was the significant reduction in HOMA-IR values, highlighting
its ability to improve insulin sensitivity and glucose regulation. The reversal of insulin resistance to near pre-diabetic levels underscores
Telomir-1’s potential as a groundbreaking therapy (Graphic).

8

Graphic
3: Effects of two forms of Telomir-1 on HOMA-IR, a measure of insulin resistance in Zebrafish

We
are currently evaluating the potential in NIDDM by studying the effect of Telomir-1 on several metabolic parameters in a rat model of
NIDDM. These studies are ongoing.

Age
reversal

We
have carried out a preclinical study, conducted in collaboration with Nagi Bioscience SA, utilized a sophisticated in vivo microfluidic-based
assay to assess the effects of Telomir-1 on the nematode Caenorhabditis elegans, a well-established model for aging studies. The microfluidic
platform allowed precise, automated tracking of lifespan, health span, and age-related mobility decline in real-time, enabling the research
team to accurately measure the effects of Telomir-1 on these critical metrics.

Two
forms of Telomir-1 were administered in two concentrations, allowing the study to examine dose-dependent responses in treated subjects.
The study found that Telomir-1 significantly enhanced lifespan and health span parameters in aged microorganism populations. Key findings
included:

    ●
    Enhanced
    Mobility in Older Organisms: Subjects treated with Telomir-1 showed improved motility, particularly in later stages of life,
    compared to untreated controls. This enhanced movement in advanced age suggests a slowing of the aging process, as mobility is a
    key indicator of biological health.

    ●
    Reduced
    Biological Aging: The study demonstrated a measurable reversal of biological age markers in subjects treated with Telomir-1.
    This significant finding points to Telomir-1’s potential to slow down, and in certain aspects, reverse biological aging, making
    it a promising candidate for longevity treatments.

    ●
    Increased
    Lifespan: Telomir-1 was associated with a statistically significant increase in lifespan among treated populations. This further
    supports Telomir-1’s role in promoting longevity

9

Graphic
4: Effect of Telomir-1 on c.elegans