Company: TVRD
Filing Date: 2025-10-20
Form Type: S-1/A
Source: 0001104659-25-100896
Chunk: 0

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-10-20
Form: S-1/A
Chunk 0
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TABLE OF CONTENTS

As filed with the Securities and Exchange Commission on October 20, 2025 Registration No. 333-287675 UNITED STATES
SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 2
to FORM S-1
REGISTRATION STATEMENT Under
The Securities Act of 1933 TVARDI THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter)

| ​ | Delaware                                                       | ​ | ​ |                                                     2834 | ​ | ​ | 75-3175693                            | ​ |
| ​ | (State or other jurisdiction ofincorporation or organization)​ | ​ | ​ | (Primary Standard IndustrialClassification Code Number)​ | ​ | ​ | -I.R.S. EmployerIdentification Number | ​ |

3 Sugar Creek Ctr. Blvd.
Suite 525
Sugar Land, TX 77478
(713) 489-8654 (Address, including zip code, and telephone number, including area code, of Registrant’s principal executive offices) Imran Alibhai
Chief Executive Officer
3 Sugar Creek Ctr. Blvd.
Suite 525
Sugar Land, TX 77478
(713) 489-8654 (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies to: Divakar Gupta
Madison A. Jones
Cooley LLP
55 Hudson Yards
New York, NY 10001
(212) 479-6000 Approximate date of commencement of proposed sale to the public : As soon as practicable after this registration statement becomes effective. If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933 check the following box: ☒ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration