Company: SPRB
Filing Date: 2025-06-06
Form Type: DEFA14A
Source: 0000950170-25-083045
Chunk: 1

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-06-06
Form: DEFA14A
Chunk 1
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 forth herein, this Supplement does not modify, amend, supplement or otherwise affect the Proxy Statement. From and after the date hereof, any reference to the Proxy Statement is to the Proxy Statement as supplemented hereby.

<div align='center'>Revised Text of the Proxy Statement</div>

1. Stockholder Letter from CEO

The stockholder letter on the pages after the cover page of the Proxy Statement and before the Table of Contents shall be amended and restated as follows:

<div align='center'>SPRUCE BIOSCIENCES, INC.
611 Gateway Boulevard, Suite 740
South San Francisco, California 94080

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

To Be Held On July 22, 2025</div>

Dear Stockholder:

You are cordially invited to attend the 2025 Annual Meeting of Stockholders (the “Annual Meeting”) of Spruce Biosciences, Inc., a Delaware corporation (the “Company”). The Annual Meeting will be held on Tuesday, July 22, 2025, at 11:00 a.m. (Pacific Time). The Annual Meeting will be held through a live webcast at www.virtualshareholdermeeting.com/SPRB2025. You will not be able to attend the meeting in person. The Annual Meeting is being held for the following purposes:

To elect the three Class II directors named below to hold office until the Company’s 2028 annual meeting of stockholders (“Proposal 1”).

Nominees:

Percival-Baretto-Ko
Bali Muralidhar, M.D., Ph.D.
Daniel Spiegelman

2. To ratify the selection by the Audit Committee of the Board of Directors of BDO USA, P.C. as the independent registered public accounting firm of the Company for the Company’s fiscal year ending December 31, 2025 (“Proposal 2”).

3. To approve an amendment to the Company's Amended and Restated Certificate of Incorporation to effect a reverse stock split (the “Reverse Stock Split”) of the Company's common stock by a ratio of between one-for-fifty and one-for-one hundred, with the exact ratio to be determined by the Board in its sole discretion and with such Reverse Stock Split to be effected at such time and date, if at all, as determined by the Board in its sole discretion (“Proposal 3” or the “Reverse Stock Split Proposal)”;

4. To approve the adjournment of the Annual Meeting, if necessary