Company: JPC
Filing Date: 2025-06-12
Form Type: 424B3
Source: 0001999371-25-007638
Chunk: 0

Company: Nuveen Preferred & Income Opportunities Fund
Filing Date: 2025-06-12
Form: 424B3
Chunk 0
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Filed Pursuant to Rule 424(b)(3)
Registration No. 333-286736

<div align='center'>IMPORTANT NOTICE TO SHAREHOLDERS OF
NUVEEN PREFERRED SECURITIES & INCOME OPPORTUNITIES FUND (JPI)
AND
NUVEEN PREFERRED & INCOME OPPORTUNITIES FUND (JPC)
(EACH, A “FUND” AND TOGETHER, THE “FUNDS”)

June 11, 2025</div>

Although we recommend that you read the complete Joint Proxy Statement/Prospectus, for your convenience, we have provided a brief overview of the proposals to be voted on.

| Q. | Why                                                           
 am I receiving the enclosed Joint Proxy Statement/Prospectus? |

| A. | You                                                                                       
 are receiving the Joint Proxy Statement/Prospectus as a holder of common shares of Nuveen 
 Preferred Securities & Income Opportunities Fund (the “Target Fund) or Nuveen             
 Preferred & Income Opportunities Fund (the “Acquiring Fund” and together                  
 with the Target Fund, the “Funds” or each individually, a “Fund”)                         
 in connection with the solicitation of proxies by each Fund’s Board of Trustees           
 (each, a “Board” and each Trustee, a “Board Member”) for use                              
 at the annual meeting of shareholders of the Target Fund and at the special meeting of    
 shareholders of the Acquiring Fund (each, a “Meeting” and together, the “Meetings”).      |

At the Meetings, shareholders of the Funds will be asked to vote on the following proposals:

| ● | (Common                                                                              
 shareholders of the Target Fund and preferred shareholders of the Acquiring Fund) to 
 approve an Agreement and Plan of Merger (the “Agreement”) pursuant to which          
 the proposed combination of the Target Fund and the Acquiring Fund (the “Merger”)    
 will be effected; and                                                                |

| ● | -Common                                                                               
 shareholders of the Target Fund) to elect members of the Board. (The list of specific 
 nominees is contained in the enclosed Joint Proxy Statement/Prospectus.               |

Shareholders of the Target Fund are being solicited to vote on the election of four (4) Board Members who have been nominated for election at the Meeting. These Board Members would continue in office in the event the Merger is not consummated in a timely manner.

Each Fund’s Board unanimously recommends that you vote FOR each proposal that is applicable to