Company: ARWR
Filing Date: 2025-03-07
Form Type: 424B7
Source: 0001193125-25-049889
Chunk: 3

Company: ARROWHEAD PHARMACEUTICALS, INC.
Filing Date: 2025-03-07
Form: 424B7
Chunk 3
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 and involve known and unknown risks, uncertainties and other factors that could cause our actual results, levels of activity, performance or achievement to differ materially from those expressed or implied by these forward-looking statements. These risks and uncertainties include, among others:

| • |     | risks relating to the cost, timing, scope and results of ongoing safety and efficacy trials of our drug 
 candidates;                                                                                             |

| • |     | risks inherent in attempting to commercialize new drugs; |

| • |     | risks relating to our ability to enter into revenue-generating collaborations or to achieve commercial acceptance 
 of our drug candidates, if approved;                                                                              |

| • |     | risks relating to our financial condition and our future capital requirements to complete development of our 
 existing drug candidates and to develop other drug candidates;                                               |

| • |     | risks relating to the validity and enforceability of our patents and potential litigation relating to 
 intellectual property rights;                                                                         |

| • |     | risks relating to our reliance on third parties; |

| • |     | risks relating to the volatility of our stock price; |

| • |     | risks relating to rapid technological change in our markets; and |

| • |     | other factors detailed from time to time in filings with the SEC. |

In addition, the factors described under the section entitled “ Risk Factors” in this prospectus supplement and the accompanying prospectus, as may be updated from time to time by our future filings under Exchange Act and elsewhere in the documents incorporated by reference in this prospectus supplement and the accompanying prospectus, may result in these differences. You should carefully review all of these factors. These forward-looking statements were based on information, plans and estimates at the date of this prospectus supplement or the other document containing the forward-looking statement, and we assume no obligation to update any forward-looking statements to reflect changes in underlying assumptions or factors, new information, future events or other changes, except as may be required by law. S-2

PROSPECTUS SUMMARY

The following summary of our business highlights certain of the information contained elsewhere in or incorporated by reference into this prospectus supplement and the accompanying prospectus. Because this is only a summary, however, it does not contain all of the information that may be important to you. You should carefully read this prospectus supplement and the accompanying prospectus, including the documents incorporated by reference, which are described under “Incorporation of Certain Information by Reference” and “Where You Can Find More Information” in this prospectus supplement and