Company: APM
Filing Date: 2025-12-05
Form Type: 424B5
Source: 0001213900-25-118752
Chunk: 130

Company: Aptorum Group Ltd
Filing Date: 2025-12-05
Form: 424B5
Chunk 130
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 as well as significant natural disasters, may affect the market may adversely
affect the business operations of our operations. Hong Kong is a special administrative region of the PRC and the basic policies
of the PRC regarding Hong Kong are reflected in the Basic Law (the “Hong Kong Basic Law” or the “Basic Law”),
namely, Hong Kong’s constitutional document, which provides Hong Kong with a high degree of autonomy and executive, legislative
and independent judicial powers, including that of final adjudication under the principle of “one country, two systems”. However,
there is no assurance that there will not be any changes in the economic, political and legal environment in Hong Kong in the future.
Since our operation is based in Hong Kong, any change of such political arrangements may pose immediate threat to the stability of
the economy in Hong Kong, thereby directly and adversely affecting our results of operations and financial positions.

Under the Basic Law of the
Hong Kong Special Administrative Region of the People’s Republic of China, Hong Kong is exclusively in charge of its internal
affairs and external relations, while the government of the PRC is responsible for its foreign affairs and defense. As a separate customs
territory, Hong Kong maintains and develops relations with foreign states and regions. Based on certain recent development including
the Law of the People’s Republic of China on Safeguarding National Security in the Hong Kong Special Administrative Region
issued by the Standing Committee of the PRC National People’s Congress in June 2020, the U.S. State Department has indicated
that the United States no longer considers Hong Kong to have significant autonomy from China and Former President Trump signed
an executive order and Hong Kong Autonomy Act (“HKAA”) to remove Hong Kong’s preferential trade status and
to authorize the U.S. administration to impose blocking sanctions against individuals and entities who are determined to have materially
contributed to the erosion of Hong Kong’s autonomy. The United States may impose the same tariffs and other trade restrictions
on exports from Hong Kong that it places on goods from mainland China. These and other recent actions may represent an escalation
in political and trade tensions involving the U.S., China and Hong Kong, which could potentially harm our business.

Given the relatively small
geographical size of Hong Kong, any of such incidents may have a widespread effect on our business operations, which could in turn
adversely and materially affect our business, results of operations and financial condition. It is difficult to predict the full impact
of the HKAA on