Company: PSTV
Filing Date: 2025-06-20
Form Type: S-1/A
Source: 0001193125-25-142935
Chunk: 20

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-06-20
Form: S-1/A
Chunk 20
---
 prior to 1:00 p.m., Eastern time, on a single Accelerated Purchase date, provided that all prior Accelerated Purchases and Additional Accelerated Purchases (including those that have occurred earlier on the same day) have been completed and all of the shares of our common stock to be purchased thereunder (and under the corresponding Regular Purchase) have been properly delivered to Lincoln Park in accordance with the Purchase Agreement. 10

The purchase price per share for each such Additional Accelerated Purchase will be equal to 96.5% of the lower of:

| • |     | the volume weighted average price of our common stock during the applicable Additional Accelerated Purchase 
 Measurement Period on the applicable Additional Accelerated Purchase date; and                              |

| • |     | the closing sale price of our common stock on the applicable Additional Accelerated Purchase date. |

In the case of Regular Purchases, Accelerated Purchases and Additional Accelerated Purchases, the purchase price per share will be equitably adjusted for any reorganization, recapitalization, non-cashdividend, stock split, reverse stock split or other similar transaction occurring during the business days used to compute the purchase price. Other than as described above, there are no trading volume requirements or restrictions under the Purchase Agreement, and we will control the timing and amount of any sales of our common stock to Lincoln Park. Minimum Share Price Under the Purchase Agreement, we and Lincoln Park may not effect any sales of shares of our common stock under the Purchase Agreement on any purchase date that the closing sale price of our common stock is less than the floor price of $0.10 per share of common stock, which will be appropriately adjusted for any reorganization, recapitalization, non-cashdividend, stock split or other similar transaction. Upon consummation of any such reorganization, recapitalization, non-cashdividend, stock split or other similar transaction, the adjusted floor price per share of common stock will be the lower of (i) the adjusted price and (ii) $0.50. Events of Suspension Events of suspension under the Purchase Agreement include the following:

| • |     | The effectiveness of the registration statement of which this prospectus forms a part lapses for any reason                                                                                                                                          
 (including, without limitation, the issuance of a stop order), or any required prospectus supplement and accompanying prospectus are unavailable for the resale by Lincoln Park of our common stock offered hereby, and such lapse or unavailability 
 continues for a period of 10 consecutive business days