Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 191

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 191
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 this prospectus is part, will be prepared and will set forth, to the extent required, the following information:

| • |     | the specific securities to be offered and sold; |

| • |     | the names of the Selling Stockholders; |

120

| • |     | the respective purchase prices and public offering prices, the proceeds to be received from the sale, if any, and 
 other material terms of the offering;                                                                             |

| • |     | settlement of short sales entered into after the date of this prospectus; |

| • |     | the names of any participating agents, broker-dealers or underwriters, if not already named herein; and |

| • |     | any applicable commissions, discounts, concessions and other items constituting compensation from the Selling 
 Stockholders.                                                                                                 |

In connection with distributions of the Resale Shares or otherwise, the Selling Stockholders may enter into hedging transactions with broker-dealers or other financial institutions. In connection with such transactions, broker-dealers or other financial institutions may engage in short sales of shares of Common Stock in the course of hedging transactions, broker-dealers or other financial institutions may engage in short sales of shares of Common Stock in the course of hedging the positions they assume with Selling Stockholders. The Selling Stockholders may also sell shares of Common Stock short and redeliver the shares to close out such short positions. The Selling Stockholders may also enter into option or other transactions with broker-dealers or other financial institutions which require the delivery to such broker-dealer or other financial institution of shares offered by this prospectus, which shares such broker-dealer or other financial institution may resell pursuant to this prospectus (as supplemented or amended to reflect such transaction). The Selling Stockholders may also pledge shares to a broker-dealer or other financial institution, and, upon a default, such broker-dealer or other financial institution, may effect sales of the pledged shares pursuant to this prospectus (as supplemented or amended to reflect such transaction). In order to facilitate the offering of the securities offered by this prospectus, any underwriters or agents, as the case may be, involved in the offering of such securities may engage in transactions that stabilize, maintain or otherwise affect the price of our securities. Specifically, the underwriters or agents, as the case may be, may over-allot in connection with the offering, creating a short position in our securities for their own account. In addition, to cover overallotments or to stabilize the price of our securities