Company: TELO
Filing Date: 2025-02-04
Form Type: 10-K
Source: 0001493152-25-004872
Chunk: 280

Company: Telomir Pharmaceuticals, Inc.
Filing Date: 2025-02-04
Form: 10-K
Item: Item 1
Chunk 280
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 life span

Graphic
5: Effect of two forms of Telomir-1 on several motility parameters

Progeria
Study: Telomir-1 Shows Promising Age-Reversal Effects

We
recently completed a study evaluating the effects of Telomir-1 in a nematode model of Progeria (Caenorhabditis elegans). The study
focused on nematodes with a mutation in the wrn-1 gene, the equivalent of the human WRN gene, which is implicated in Werner Syndrome,
a form of Progeria. In C. elegans, wrn-1 depletion is associated with a significantly reduced mean and median lifespan compared to normal
(wild-type) organisms.

The
study demonstrated significant age-reversal effects in wrn-1-mutated nematodes treated with Telomir-1. Treatment effectively restored
longevity levels to those comparable to wild-type organisms. Additional benefits included an extended healthy lifespan and normalization
of physiological parameters such as movement velocity and tail amplitude.

Further
studies in a Progeria human cell line are planned in collaboration with Smart Assays to build on these promising findings.

10

Oxidative
Stress Study: Telomir-1 Shows potential to Fully Reverse Oxidative Stress and Provide Robust Cellular Protection

Oxidative
stress is a key driver of aging and disease progression, contributing to conditions such as Alzheimer’s, Age-related Macular Degeneration
(AMD), cardiovascular diseases, cancer, and diabetes. It also plays a critical role in the severity of viral infections, including avian
influenza (bird flu), by increasing inflammation, cellular damage, and impairing immune responses. Addressing oxidative stress is essential
for mitigating these effects and improving patient outcomes.

Telomir
Pharmaceuticals recently conducted preclinical studies in collaboration with Smart Assays Biotechnologies Ltd. to evaluate Telomir-1’s
ability to combat copper-induced oxidative stress. The study, performed in human cell lines, demonstrated:

  ●
  Reversal of Oxidative Stress – Telomir-1 fully
normalized Reactive Oxygen Species (ROS) levels, effectively reversing oxidative damage.

  ●
  Cellular Protection – Telomir-1 provided strong protection against copper-induced toxicity
  while maintaining cellular integrity.

  ●
  Regulatory Mechanism – Telomir-1 demonstrated effects at doses significantly lower than
  copper levels, indicating a unique