Company: APM
Filing Date: 2025-12-05
Form Type: 424B5
Source: 0001213900-25-118752
Chunk: 389

Company: Aptorum Group Ltd
Filing Date: 2025-12-05
Form: 424B5
Chunk 389
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 Selling Securityholder transfers securities under conditions which require
the purchaser or transferee to be named in the prospectus as a selling shareholder, in which case we will be required to amend or supplement
this prospectus to name the selling shareholder, or (b) the selling shareholder sells shares to an underwriter, in which case we
will be required to amend or supplement this prospectus to name the underwriter and the method of sale.

We are paying all fees and
expenses incident to the registration of the shares. We have agreed to indemnify the Selling Securityholders against certain losses, claims,
damages and liabilities, including liabilities under the Securities Act.

We agreed to keep this prospectus
effective until the earlier of (i) the date on which the securities may be resold by the Selling Securityholders without registration
and without regard to any volume or manner-of-sale limitations by reason of Rule 144, without the requirement for the Company to be in
compliance with the current public information under Rule 144 under the Securities Act or any other rule of similar effect or (ii) all
of the securities have been sold pursuant to this prospectus or Rule 144 under the Securities Act or any other rule of similar effect.
The resale securities will be sold only through registered or licensed brokers or dealers if required under applicable state securities
laws. In addition, in certain states, the resale securities covered hereby may not be sold unless they have been registered or qualified
for sale in the applicable state or an exemption from the registration or qualification requirement is available and is complied with.

Under applicable rules and
regulations under the Exchange Act, any person engaged in the distribution of the resale securities may not simultaneously engage in market
making activities with respect to the common stock for the applicable restricted period, as defined in Regulation M, prior to the commencement
of the distribution. In addition, the Selling Securityholders will be subject to applicable provisions of the Exchange Act and the rules
and regulations thereunder, including Regulation M, which may limit the timing of purchases and sales of the common stock by the Selling
Securityholders or any other person. We will make copies of this prospectus available to the Selling Securityholders and have informed
them of the need to deliver a copy of this prospectus to each purchaser at or prior to the time of the sale (including by compliance with
Rule 172 under the Securities Act).

<div align='center'>TAXATION</div>

The following summary contains a description of certain Cayman Islands and U.S.