Company: RPTX
Filing Date: 2025-04-29
Form Type: DEF 14A
Source: 0001193125-25-103764
Chunk: 78

Company: Repare Therapeutics Inc.
Filing Date: 2025-04-29
Form: DEF 14A
Chunk 78
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 via email at investor@reparerx.com. Shareholders who currently receive multiple copies of the Notices of Internet Availability of Proxy Materials at their addresses and would like to request “householding” of their communications should contact their brokers.

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OTHER MATTERS Our board of directors knows of no other matters that will be presented for consideration at the Annual Meeting. If any other matters are properly brought before the Annual Meeting, it is the intention of the persons named in the accompanying proxy to vote on such matters in accordance with their best judgment.

| By Order of the Board of Directors,                                      |
| Steve Forte                                                              |
| President, Chief Executive Officer, Chief Financial Officer and Director |

April 29, 2025 We have filed our Annual Report on Form 10-Kfor the fiscal year ended December 31, 2024 with the SEC and Canadian securities regulatory authorities. It is available free of charge at the SEC’s website at www.sec.gov and on SEDAR+ at www.sedarplus.ca. Shareholders can also access this proxy statement and our 2024 Annual Report on Form 10-Kat ir.reparerx.com. A copy of our Annual Report on Form 10-Kfor the fiscal year ended December 31, 2024 is also available without charge by written request to our Secretary at c/o Repare Therapeutics Inc., 7171 Frederick-Banting, Building 2, Suite 270, St-Laurent,Québec, Canada H4S 1Z9, Attention: Secretary or via email at investor@reparerx.com. 59

P. O. BOX 8016, CARY, NC 27512-9903 Your vote matters! Have your ballot ready and please use one of the methods below for easy voting: Your control number Have the 12 digit control number located in the box above available when you access the website and follow the instructions. Repare Therapeutics Inc. Internet: www.proxypush.com/RPTX Cast your vote online Annual Meeting of Shareholders Have your Proxy Card ready Follow the simple instructions to record your vote For Shareholders of Record as of April 21, 2025 Phone: Tuesday, June 17, 2025 10:00 AM, Eastern Time 1-866-858-9058Use any touch-tone telephone Annual Meeting will be held live via the Internet—please visit Have your Proxy Card ready www.proxydocs.com/RPTX for more details. Follow the simple