Company: NCNA
Filing Date: 2025-06-18
Form Type: F-3/A
Source: 0001193125-25-142565
Chunk: 1

Company: NuCana plc
Filing Date: 2025-06-18
Form: F-3/A
Chunk 1
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 ☐ If this Form is a registration statement pursuant to General Instruction I.C. or a post-effective amendment thereto that shall become effective on filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. ☐ If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.C. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. ☐ Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933. Emerging growth company ☐ If an emerging growth company that prepares its financial statements in accordance with U.S. GAAP, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards† provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until the registration statement shall become effective on such date as the Commission, acting pursuant to said Section 8(a), may determine.

EXPLANATORY NOTE

NuCana plc (the “Company”) is filing this Pre-Effective Amendment No. 1 (this
“Amendment No. 1”) to the Registration Statement on Form F-3 (File No. 333-281576) originally filed on August 15, 2024 (the “Registration
Statement”) solely for the purposes of including (i) our Annual Report on Form 20-F for the fiscal year ended December 31, 2024, as filed with the Securities and Exchange Commission (the
“SEC”) on March 20, 2025 under the section “Incorporation of Documents by Reference” and (ii) our Reports on Form 6-K, as filed with the SEC on April 23, 2025, June 2,
2025, and June 5, 2025 under the section “Incorporation of Documents by Reference”, (iii) the Company’s articles of association, dated as of April 23, 2025, incorporated by reference as Exhibit 3.1 to this Amendment