Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063899
Chunk: 182

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 182
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 last period.

Research and development expenses

The following table sets forth
a summary of our research and development expenses for the years ended December 31, 2023, and 2022. As a consequence of exclusive emphasis
on its lead projects and suspension of non-lead projects, there was a notable decrease in the utilization of external consultants and
full impairment of patents related to these non-lead projects. Moreover, the payroll expenses for research and development staff decreased
as a result of the reversal of deferred cash bonus payables to employees and consultants, and reduction of employees during current period.
The reversal was due to the Group’s agreements with employees and consultants to discharge the Group’s obligation to settle
their outstanding deferred cash bonus payables from previous years in exchange of fully vested ordinary shares.

|                                                         |     |   |   Year Ended 
 December 31, 
         2023 |     |   |   Year Ended 
 December 31, 
         2022 |
|:--------------------------------------------------------|:----|:--|-------------:|:----|:--|-------------:|
| Research and Development Expenses:                      |     |   |              |     |   |              |
| Payroll expenses                                        |     | $ |      363,139 |     | $ |    1,305,363 |
| Contracted research organizations services              |     |   |    1,387,534 |     |   |    1,709,927 |
| Sponsored research                                      |     |   |       17,149 |     |   |       17,061 |
| Amortization and depreciation                           |     |   |    1,071,455 |     |   |    1,064,012 |
| Consultation                                            |     |   |    1,207,188 |     |   |    4,423,963 |
| Loss on disposal and impairments of an intangible asset |     |   |      519,497 |     |   |      205,189 |
| Other R&D expenses                                      |     |   |      632,367 |     |   |      494,080 |
| Total Research and Development Expenses                 |     | $ |    5,198,329 |     | $ |    9,219,595 |

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General and administrative fees

The following table sets forth
a summary of our general and administrative expenses for the years ended