Company: SHPH
Filing Date: 2025-12-11
Form Type: S-1/A
Source: 0001493152-25-027310
Chunk: 8

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-12-11
Form: S-1/A
Chunk 8
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 is critical to our future operating results. Factors that may affect the acquisition
of new customers and renewal rates for future customers include:

| ● | the price, performance, and functionality of our        
 platform;                                               |
| ● | the availability, price, performance, and functionality 
 of competing software solutions;                        |
| ● | the success of competitive products or technologies;    |
| ● | the stability, performance, and security of our         
 technological infrastructure; and                       |
| ● | the business environment of our future customers.       |

If we fail to acquire
new customers, if we are unable to successfully renew agreements with such clients or if clients renew such agreements upon less favorable
terms or at lower fee levels, our future revenues may be negatively impacted.

<div align='center'>CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS</div>

All statements in this prospectus
and the documents incorporated by reference that are not historical facts should be considered “Forward Looking Statements”
within the meaning of the “Safe Harbor” provisions of the Private Securities Litigation Reform Act of 1995. Such statements
involve known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements of the Company
to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements.
Some of the forward-looking statements can be identified by the use words such as “believe,” “expect,” “may,”
“estimates,” “should,” “seek,” “approximately,” “intend,” “plan,”
“estimate,” “project,” “continue” or “anticipates” or similar expressions or words, or
the negatives of those expressions or words. These statements may be made directly in this prospectus and they may also be incorporated
by reference in this prospectus from other documents filed with the SEC, and include, but are not limited to, statements about future
financial and operating results and performance, statements about our plans, objectives, expectations and intentions with respect to
future operations and products, and other statements that are not historical facts. These forward-looking statements are based upon the
current beliefs and expectations of our management and are inherently subject to significant business, economic and competitive uncertainties
and contingencies, many of which are difficult to predict and generally beyond our control. In addition, these forward-looking statements
are subject to assumptions with respect to future business strategies and decisions that are subject to change. Actual results may differ
materially from the anticipated results discussed in