Company: CSTL
Filing Date: 2025-11-03
Form Type: S-8
Source: 0001628280-25-048270
Chunk: 2

Company: CASTLE BIOSCIENCES INC
Filing Date: 2025-11-03
Form: S-8
Chunk 2
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 and September 30, 2025, filed with the SEC on May 5 , 202 5 , August 4 , 202 5 and November 3 , 202 5 , respectively.

(c) The Registrant’s Current Reports on Form 8-K, filed with the SEC on May 2 3 , 2025 and August 8 , 2025 .

(d) The description of the Registrant’s Common Stock contained in the Registrant’s registration statement on Form 8-A filed with the SEC on July 15, 2019, (File No. 001-38984) under Section 12(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), as updated by Exhibit 4.1 to the Registrant's Annual Report on Form 10-K for the year ended December 31, 2019 filed with the SEC on March 10, 2020 (File No. 001-38984), including any amendment or report filed for the purpose of updating such description.

All documents, reports and definitive proxy or information statements filed by the Registrant pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act after the date of this Registration Statement and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part hereof from the date of filing of such documents; provided, however, that documents, reports and definitive proxy or information statements, or portions thereof, which are furnished and not filed in accordance with the rules of the SEC shall not be deemed incorporated by reference into this Registration Statement unless specifically stated to the contrary. Any statement contained in a document incorporated or deemed to be incorporated herein by reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes that statement. Any such statement so modified or superseded shall not constitute a part of this Registration Statement, except as so modified or superseded.

## ITEM 8. EXHIBITS.
| Exhibit Number 
 4.1            
 4.2            |     | Description                                                                                                                                                                                                                                                                                                                  
 Amended and Restated Certificate of Incorporation of the Registrant, incorporated by reference to