Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 80

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 80
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ERICA INCORPORATED

Comerica Incorporated is a financial services company, incorporated under the laws of the State of Delaware in 1973, and headquartered in Dallas, Texas. Based
on total assets as reported in the most recently filed Consolidated Financial Statements for Bank Holding Companies (FR Y-9C), it was among the largest commercial United States (“U.S.”) financial
holding companies. As of September 30, 2023, Comerica owned directly or indirectly all the outstanding common stock of 2 active banking subsidiaries (Comerica Bank, a Texas banking association, and Comerica Bank & Trust, National
Association) as well as non-banking subsidiaries. At September 30, 2023, Comerica had total assets of approximately $85.7 billion, total deposits of approximately $67.2 billion, total loans of
approximately $53.4 billion and shareholders’ equity of approximately $5.0 billion.

Comerica has strategically aligned its operations into
three major business segments: the Commercial Bank, the Retail Bank, and Wealth Management. Comerica operates in three primary geographic markets—Texas, California, and Michigan, as well as in Arizona and Florida, with select businesses
operating in several other states, and in Canada and Mexico.

Comerica’s principal executive office is at Comerica Bank Tower, 1717 Main Street,
Dallas, Texas 75201, and its telephone number is (214) 462-6831.

2

RISK FACTORS

Investing in our securities involves certain risks. Before you invest in any of our securities, in addition to the other information included in, or
incorporated by reference into, this prospectus, you should carefully consider the risk factors contained in Item 1A under the caption “Risk Factors” and elsewhere in our annual report on Form 10-K
for the fiscal year ended December 31, 2022, which is incorporated into this prospectus by reference, as updated by our annual or quarterly reports for subsequent fiscal years or fiscal quarters that we file with the SEC and that are so
incorporated. See “Where You Can Find More Information” for information about how to obtain a copy of these documents. You should also carefully consider the risks and other information that may be contained in, or incorporated by
reference into, any prospectus supplement relating to specific offerings of securities.

USE OF PROCEEDS

Comerica intends to use the net proceeds from the sale