Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 5

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 5
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 distribution of this prospectus outside the United States.

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ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement on Form S-1 that we filed with the Securities and
Exchange Commission (the “SEC”) using the “shelf” registration process. Under this shelf registration process, the Selling Stockholders may, from time to time, sell the securities offered by them described in this prospectus.
We will not receive any proceeds from the sale by such Selling Stockholders of the securities offered by them described in this prospectus. This prospectus also relates to the issuance by us of the shares of Common Stock issuable upon the exercise
of the Exchange Warrants. We will not receive any proceeds from the sale of shares of Common Stock underlying the Exchange Warrants, September 2025 Warrants or November 2025 Warrants pursuant to this prospectus, except with respect to amounts
received by us upon the exercise of such warrants for cash.

Neither we nor the Selling Stockholders have authorized anyone to provide you
with any information or to make any representations other than those contained in this prospectus or any applicable prospectus supplement or any free writing prospectuses prepared by or on behalf of us or to which we have referred you. Neither we
nor the Selling Stockholders take responsibility for, and can provide no assurance as to the reliability of, any other information that others may give you. Neither we nor the Selling Stockholders will make an offer to sell these securities in any
jurisdiction where the offer or sale is not permitted.

We may also provide a prospectus supplement or post-effective amendment to this
registration statement to add information to, or update or change information contained in, this prospectus. You should read both this prospectus and any applicable prospectus supplement or post-effective amendment to the registration statement
together with the additional information to which we refer you in the section of this prospectus entitled “Where You Can Find More Information.”

On November 10, 2022, we consummated the business combination (the “Scilex Business Combination”) pursuant to that certain
Agreement and Plan of Merger, dated as of March 17, 2022 (as amended, restated or supplemented from time to time, including by Amendment No. 1 to Agreement and Plan of Merger, dated as of September 12, 2022) (the “Merger
Agreement”), by and among us, Vantage Merger Sub Inc., our then-wholly owned subsidiary