Company: RVRC
Filing Date: 2025-12-12
Form Type: S-1/A
Source: 0001213900-25-121070
Chunk: 95

Company: Revium Rx.
Filing Date: 2025-12-12
Form: S-1/A
Chunk 95
---
3×): reflects slower uptake, stronger generic competition, and price compression. |

| ● | Gonorrhea                                                                                
 (4×): reflects higher ex-U.S. burden, faster uptake, fewer alternatives, and more direct 
 revenue translation.                                                                     |

The assumed pricing profile is based on benchmarks
from systemic antibiotics used for resistant infections. While the potential application of Nano-Mupirocin in high-mortality, high-cost
indications such as invasive MRSA supports commercial attractiveness and meaningful global revenue potential, these estimates are our
assumptions that are illustrative only. Actual outcomes will depend on future clinical trial results, regulatory approvals, regional
treatment guidelines, reimbursement decisions, and market adoption.

Our product candidate is still in preclinical
development and has not been approved by any regulatory authority. We do not yet know the final dosage, or number of injections required
per treatment course, and actual pricing will depend on multiple factors including clinical results, regulatory approval, reimbursement,
adoption, and competition.

References

| 1. | https://www.tropicalmedicine.ox.ac.uk/gram/news/drug-resistant-enteric-fever-has-risen-53-percent-since-1990-gram-study-estimates |

| 2. | CDC (2022). Gonorrhea                                                            
 Treatment Guidelines. https://www.cdc.gov/std/treatment-guidelines/gonorrhea.htm |

| 3. | WHO (2021). Antimicrobial                                                                          
 Resistance in Gonorrhea. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance |

| 4. | Red Book Online (2024).                   
 Amphotericin B and AmBisome Pricing Data. |

| 5. | GoodRx (2024). Ceftriaxone                       
 Average Cost. https://www.goodrx.com/ceftriaxone |

| 6. | Drugs.com (2024). Mupirocin                                   
 Ointment Pricing. https://www.drugs.com/price-guide/mupirocin |

| 7. | CDC (2022). STD Surveillance                                            
 Report – Gonorrhea. https://www.cdc.gov/std/statistics/2022/default.htm |

| 8. | CDC (2020). Healthcare-Associated 
 Infections (HAI) Reports – MRSA.  |

| 9. | NIH/NIAID. Treatment                    
 Failures and Resistance Trends in MRSA. |

| 10. | Inc