Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 32

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 32
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, 2024, taking into account the Reverse Stock Split, with |

21

| • |     | 18,665 shares of Common Stock issuable upon the exercise of stock options outstanding under the 2017 Scilex                            
 Pharmaceuticals Inc. Equity Incentive Plan (the “Scilex Pharma 2017 Plan”) with a weighted average exercise price of $26.95 per share; |

| • |     | 432,087 shares of Common Stock issuable upon the exercise of stock options outstanding under the 2019 Stock            
 Option Plan of Scilex, Inc. (the “2019 Stock Option Plan”) with a weighted average exercise price of $60.55 per share; |

| • |     | 571,738 shares of Common Stock issuable upon the exercise of stock options outstanding under the Scilex Holding                
 Company 2022 Equity Incentive Plan (the “Equity Incentive Plan”), with a weighted average exercise price of $200.55 per share; |

| • |     | up to 494,662 shares of Common Stock available for future issuance under the Equity Incentive Plan; |

| • |     | up to 118,350 shares of Common Stock available for future issuance under the Scilex Holding Company 2022 Employee 
 Stock Purchase Plan (the “ESPP”);                                                                                 |

| • |     | up to 40,000 shares of Common Stock available for future issuance under the Scilex Holding Company 2023 
 Inducement Plan (the “Inducement Plan”);                                                                |

| • |     | up to 6,958,309 SPAC Warrants (as defined below on a pre-Reverse Stock                                                                                                                           
 Split basis), which are currently exercisable for an aggregate of up to 198,810 shares (on a post-Reverse Stock Split basis) of Common Stock, with an exercise price of $402.50 per whole share; |

| • |     | 108,686 shares of Common Stock issuable upon the exercise of the warrants to purchase shares of Common Stock, 
 with an exercise price of $59.50 per share;                                                                   |

| • |     | 13,446 shares of Common Stock issuable upon the exercise of the warrants to purchase shares of Common Stock, with 
 an exercise price of $74.38 per share;                                                                            |

| • |     | 428,572 shares of Common Stock issuable upon the exercise of the warrants to purchase shares of