Company: PSTV
Filing Date: 2025-04-01
Form Type: PRER14A
Source: 0001140361-25-011649
Chunk: 2

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-01
Form: PRER14A
Chunk 2
---
     |   22 |
| Stock Ownership Information                                                                |     |   23 |
| Annexes                                                                                    |     |      |
| Annex A: Certificate of Amendment to the Amended and Restated Certificate of Incorporation |     |  A-1 |
| Annex B: Certificate of Amendment to the Amended and Restated Certificate of Incorporation |     |  B-1 |

i

#### TABLE OF CONTENTS

#### PLUS THERAPEUTICS, INC.

#### 2710 Reed Rd, Suite 160,

#### Houston, TX 77051

### PROXY STATEMENT

### SPECIAL MEETING OF STOCKHOLDERS
<div align='center'>**To Be Held on April [ ], 2025 at [9:00 a.m. (Eastern Time)]**</div>

This proxy statement (the “Proxy Statement”) and the enclosed proxy card are being furnished in connection with the solicitation of proxies by the Board of Directors (the “Board”) of Plus Therapeutics, Inc. for use at our 2025 Special Meeting of Stockholders (the “Special Meeting”), to be held in a completely virtual format on April [ ], 2025, at [9:00 a.m. Eastern Time] for the purposes stated in the accompanying Notice of Special Meeting of Stockholders, and at any adjournment of postponements of the Special Meeting. This solicitation is made by our Board on behalf of Plus Therapeutics, Inc. In this Proxy Statement, the terms “we,” “our,” “us” and the “Company” refer to Plus Therapeutics, Inc.

We have elected to provide access to our proxy materials over the Internet. Accordingly, we are sending to our stockholders of record as of the close of business on March 4, 2025, the Notice of Internet Availability of Proxy Materials (the “Notice”) relating to our Special Meeting of Stockholders. All stockholders of record will have the ability to access the proxy materials on the website referred to in the Notice or to request to receive a printed set of the proxy materials. Instructions on how to request a printed copy by mail or electronically may be found on the Notice and on the website referred to in the Notice, including an option to request paper copies on an ongoing basis. On or about April [ ], 2025, we intend to make this Proxy Statement and accompanying form of proxy card available on the Internet and to mail the Notice to all stockholders entitled to vote at the Special Meeting. We intend to mail this