Company: NCNA
Filing Date: 2025-07-16
Form Type: F-6 POS
Source: 0001193805-25-001028
Chunk: 4

Company: NuCana plc
Filing Date: 2025-07-16
Form: F-6 POS
Chunk 4
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| CITIBANK, N.A., solely in its capacity as Depositary                                                                                                                                                                                                                       |                          |
| By:                                                                                                                                                                                                                                                                        | /s/ Thomas Crane         |
|                                                                                                                                                                                                                                                                            | Name:  Thomas Crane      |
|                                                                                                                                                                                                                                                                            | Title:    Vice President |

<div align='center'>II-3</div>

Pursuant to the requirements
of the Securities Act of 1933, as amended, NuCana plc certifies that it has reasonable grounds to believe that all the requirements for
filing on Form F-6 are met and has duly caused this Post-Effective Amendment No. 1 to Registration Statement on Form F-6 to be signed
on its behalf by the undersigned thereunto duly authorized, in Nether Alderley, United Kingdom, on July 16, 2025.

| NUCANA PLC |                                                                                               |
| By:        | /s/ Andrew Kay                                                                                |
|            | Name:  Andrew Kay                                                                             |
|            | Title:    Executive Chairman of the Board of Directors and Acting Principal Executive Officer |

<div align='center'>II-4</div>

Pursuant to the requirements
of the Securities Act of 1933, as amended, this Post-Effective Amendment No. 1 to Registration Statement on Form F-6 has been signed by
the following persons in the following capacities on July 16, 2025.

| Signature             |     | Title                                                             |
| /s/ Andrew Kay        |     | Executive Chairman of the Board of Directors and Acting Principal |
| Andrew Kay            |     | Executive Officer (Principal Executive Officer) and Director      |
| /s/ Ian Webster       |     | Interim Chief Financial Officer (Principal Financial and          |
| Ian Webster           |     | Accounting Officer)                                               |
| /s/ Cyrille Leperlier |     | Director                                                          |
| Cyrille Leperlier     |     |                                                                   |
| /s/ Martin Mellish    |     | Director                                                          |
| Martin Mellish        |     |                                                                   |
| /s/ Elliott Levy      |     | Director                                                          |
| Elliott Levy          |     |                                                                   |

<div align='center'>II-5

SIGNATURE OF AUTHORIZED REPRESENTATIVE OF THE REGISTRANT</div>

Under the Securities Act of
1933, as amended, the undersigned, the duly authorized representative in the United States of America, has signed this Post-Effective
Amendment No. 1 to Registration Statement on