Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 10

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 10
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 up to an aggregate of 214,284                     
 shares of our Common Stock, with a current exercise price of $36.40 per share, issued to the Tranche B Noteholders. |

| • |     | “October 2024 Placement Agent Warrants” means the warrants to purchase up to an aggregate of                                                                                                     
 104,848 shares of Common Stock, with a current exercise price of $36.40 per share, issued to StockBlock and Rodman & Renshaw LLC in connection with the Tranche B Securities Purchase Agreement. |

| • |     | “October 2024 Warrants” means the October 2024 Noteholder Warrants and the October 2024 
 Placement Agent Warrants.                                                               |

| • |     | “Oramed” means Oramed Pharmaceuticals Inc., a Delaware corporation. |

| • |     | “Oramed Note” means that certain senior secured promissory note issued by us on                               
 September 21, 2023 to Oramed due 18 months from the date of issuance in the principal amount of $101,875,000. |

| • |     | “Penny Warrants” means the warrants to purchase up to an aggregate of 13,000,000 shares of our                    
 Common Stock, each with an exercise price of $0.01 per share, issued to Oramed pursuant to the Scilex-Oramed SPA. |

| • |     | “Private Warrants” means the 6,840,000 warrants sold in a private placement to Vickers                                                                                                                                              
 Venture Fund VI Pte Ltd and Vickers Venture Fund VI (Plan) Pte Ltd consummated on January 11, 2021 (of which 2,736,000 were forfeited pursuant to the Sponsor Support Agreement and 3,104,000 were transferred to Sorrento pursuant 
 to the Warrant Transfer Agreement, in each case in connection with the Business Combination).                                                                                                                                       |

| • |     | “public shareholders” means the holders of the public shares. |

7

| • |     | “public shares” means the Vickers Ordinary Shares which were sold as part of the IPO, whether                                                                                                                                                           
 they were purchased in the IPO or in the aftermarket, including any of our Initial Shareholders to the extent that they purchase such public shares (except that our Initial Shareholders will not have conversion or tender rights with respect to any 
 public shares they own).                                                                                                                                                                                                                                |

| • |     | “Public