Company: PTHS
Filing Date: 2025-09-29
Form Type: 424B3
Source: 0001753926-25-001561
Chunk: 1

Company: Pelthos Therapeutics Inc.
Filing Date: 2025-09-29
Form: 424B3
Chunk 1
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88.

Investing in our securities involves risks. You should carefully review the risks described under the heading “Risk Factors” beginning on page 7and in the documents which are incorporated by reference herein and contained in the applicable prospectus supplement before you invest in our securities.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is September 24, 2025.

TABLE OF CONTENTS</div>

|                                                   | Page |
| ABOUT THIS PROSPECTUS                             |    1 |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |    2 |
| PROSPECTUS SUMMARY                                |    3 |
| RISK FACTORS                                      |    7 |
| THE OFFERING                                      |   34 |
| USE OF PROCEEDS                                   |   35 |
| DESCRIPTION OF CAPITAL STOCK                      |   38 |
| PRIVATE PLACEMENT OF SERIES A PREFERRED STOCK     |   36 |
| JULY 2025 MERGER TRANSACTION                      |   37 |
| SELLING STOCKHOLDERS                              |   44 |
| PLAN OF DISTRIBUTION                              |   46 |
| LEGAL MATTERS                                     |   48 |
| EXPERTS                                           |   49 |
| WHERE YOU CAN FIND MORE INFORMATION               |   50 |
| INCORPORATION OF DOCUMENTS BY REFERENCE           |   51 |

You should rely only on the information contained in this prospectus and any accompanying prospectus supplement or incorporated by reference in these documents. No dealer, salesperson or other person is authorized to give any information or to represent anything not contained or incorporated by reference in this prospectus or the accompanying prospectus supplement. If anyone provides you with different, inconsistent or unauthorized information or representations, you must not rely on them. This prospectus and any accompanying prospectus supplement are an offer to sell only the securities offered by these documents, but only under circumstances and in jurisdictions where it is lawful to do so. The information contained in this prospectus or any prospectus supplement is current only as of the date on the front of those documents.

<div align='center'>ABOUT THIS PROSPECTUS</div>

This prospectus is part of a registration statement that we filed with the U.S. Securities and Exchange Commission (the “SEC”). By using a shelf registration statement, the Selling