Company: RGNX
Filing Date: 2025-03-13
Form Type: POSASR
Source: 0001193125-25-053917
Chunk: 24

Company: REGENXBIO Inc.
Filing Date: 2025-03-13
Form: POSASR
Chunk 24
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 one or more global securities. Each global security will:

| • |     | be registered in the name of a depositary, or its nominee, that we will identify in a prospectus supplement; |

| • |     | be deposited with the trustee as custodian for the depositary; and |

| • |     | bear any required legends. |

No global security may be exchanged in whole or in part for debt securities registered in the name of any person other than the depositary or any nominee unless:

| • |     | the depositary has notified us that it is unwilling or unable to continue as depositary or has ceased to be 
 qualified to act as depositary;                                                                             |

| • |     | an event of default has occurred and is continuing with respect to the debt securities of the applicable series; 
 or                                                                                                               |

| • |     | any other circumstance described in a prospectus supplement has occurred permitting or requiring the issuance of 
 any such security.                                                                                               |

As long as the depositary, or its nominee, is the registered owner of a global security, the depositary or nominee will be considered the absolute owner of the debt securities represented by the global security for all purposes under the indenture. Participants in the depositary have no rights under the indenture with respect to the global securities held on their behalf by the depositary. Payments on a global security will be made to the depositary or its nominee as the holder of the global security. Some jurisdictions have laws that require that certain purchasers of securities take physical delivery of such securities in definitive form. These laws may impair the ability to transfer beneficial interests in a global security. 15

Ownership of beneficial interests in a global security are required to be shown on and effected through the book entry system maintained by the depositary (or its nominee), with respect to participants’ interests, or any participant, with respect to interests of persons held by participants on their behalf. Payments, transfers and exchanges relating to beneficial interests in a global security will be subject to policies and procedures of the depositary and must be effected through the depositary’s (or its nominee’s) book entry system. The depositary’s policies and procedures may change from time to time. We and the trustee have no responsibility or liability for the depositary’s or any participant’s records with respect to beneficial interests in a global security. Events of Default Unless we indicate otherwise in a prospectus supplement with respect to a particular series of debt securities, the following will be events of default for any series of debt