Company: WHWK
Filing Date: 2025-04-25
Form Type: 424B5
Source: 0001193125-25-097064
Chunk: 2

Company: Whitehawk Therapeutics, Inc.
Filing Date: 2025-04-25
Form: 424B5
Chunk 2
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 S-10 |
| Use of Proceeds                                   |     |      | S-12 |
| Plan of Distribution                              |     |      | S-13 |
| Legal Matters                                     |     |      | S-15 |
| Experts                                           |     |      | S-15 |
| Where You Can Find More Information               |     |      | S-15 |
| Incorporation of Certain Information by Reference |     |      | S-16 |

PROSPECTUS

|                                     |     | Page |    |
| About this Prospectus               |     |      | ii |
| Prospectus Summary                  |     |      |  1 |
| Risk Factors                        |     |      |  5 |
| Forward-Looking Statements          |     |      |  5 |
| Use of Proceeds                     |     |      |  6 |
| Description of Capital Stock        |     |      |  6 |
| Description of Debt Securities      |     |      |  7 |
| Description of Warrants             |     |      | 14 |
| Description of Units                |     |      | 15 |
| Plan of Distribution                |     |      | 15 |
| Legal Matters                       |     |      | 18 |
| Experts                             |     |      | 18 |
| Where You Can Find More Information |     |      | 18 |
| Incorporation by Reference          |     |      | 19 |

ABOUT THIS PROSPECTUS SUPPLEMENT

This prospectus supplement is part of a registration statement on Form S-3 that we have filed with the U.S.
Securities and Exchange Commission (the “SEC”), utilizing a “shelf” registration process. By using a shelf registration statement, we may offer shares of our common stock having an aggregate offering price of up to $75,000,000
from time to time under this prospectus supplement at prices and on terms to be determined by market conditions at the time of offering. The $75,000,000 of shares of our common stock that may be sold under this prospectus are included in the
$150,000,000 of shares of securities that may be sold under the registration statement.

We provide information to you about this offering of shares
of our common stock in two separate documents that are bound together: (1) this prospectus supplement, which describes the specific details regarding this offering; and (2) the accompanying prospectus, which provides general information,
some of which may not apply