Company: PFSA
Filing Date: 2025-05-13
Form Type: S-4/A
Source: 0001213900-25-042224
Chunk: 21

Company: Profusa, Inc.
Filing Date: 2025-05-13
Form: S-4/A
Chunk 21
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MENT NO. 1 TO MERGER AGREEMENT                                     |     | A-1-1 |
| ANNEX A-2: AMENDMENT NO. 2 TO MERGER AGREEMENT                                     |     | A-2-1 |
| ANNEX A-3: AMENDMENT NO. 3 TO MERGER AGREEMENT                                     |     | A-3-1 |
| ANNEX A-4: AMENDMENT NO. 4 TO MERGER AGREEMENT                                     |     | A-4-1 |
| ANNEX A-5: AMENDMENT NO. 5 TO MERGER AGREEMENT                                     |     | A-5-1 |
| ANNEX B — PROPOSED CERTIFICATE OF INCORPORATION                                    |     |   B-1 |
| ANNEX C — PROPOSED EQUITY INCENTIVE PLAN                                           |     |   C-1 |
| ANNEX D — PROPOSED EMPLOYEE STOCK PURCHASE PLAN                                    |     |   D-1 |
| ANNEX E — PROPOSED BYLAWS                                                          |     |   E-1 |
| ANNEX F — FAIRNESS OPINION OF MARSHALL & STEVENS TRANSACTION ADVISORY SERVICES LLC |     |   F-1 |
| INFORMATION NOT REQUIRED IN PROSPECTUS                                             |     |  II-1 |

ii MARKET AND INDUSTRY DATA This proxy statement/prospectus contains estimates, projections, and other information concerning Profusa’s industry and business, as well as data regarding market research, estimates, and forecasts prepared by Profusa’s management. Information that is based on estimates, forecasts, projections, market research, or similar methodologies is inherently subject to uncertainties, and actual events or circumstances may differ materially from events and circumstances that are assumed in this information. The industry in which Profusa operates is subject to a high degree of uncertainty and risk due to a variety of factors, including those described in the section entitled “ Risk Factors.” Unless otherwise expressly stated, Profusa obtained this industry, business, market, and other data from reports, research surveys, studies, and similar data prepared by market research firms and other third parties, industry and general publications, government data, and similar sources that Profusa did not pay for, sponsor, conduct or otherwise commission. Forecasts and other forward -lookinginformation with respect to industry, business, market, and other data are subject to the same qualifications and additional uncertainties regarding the other forward -lookingstatements in this proxy statement/prospect