Company: RPTX
Filing Date: 2025-04-29
Form Type: DEF 14A
Source: 0001193125-25-103764
Chunk: 80

Company: Repare Therapeutics Inc.
Filing Date: 2025-04-29
Form: DEF 14A
Chunk 80
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 or withheld from voting or voted against each of the matters described herein, as applicable, in accordance with the instructions of the holder, on any ballot that may be called for and, if the holder has specified a choice with respect to any matter to be acted on, the securities will be voted accordingly. This proxy should be read in conjunction with the proxy statement for the 2025 Annual Meeting of Shareholders of the Company. PLEASE BE SURE TO SIGN AND DATE THIS PROXY CARD AND MARK ON THE REVERSE SIDE Copyright © 2025 BetaNXT, Inc. or its affiliates. All Rights Reserved

Repare Therapeutics Inc. Annual Meeting of Shareholders Please make your marks like this: THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR EACH OF THE DIRECTOR NOMINEES LISTED IN PROPOSAL 1 AND FOR PROPOSALS 2 AND 3 BOARD OF DIRECTORS PROPOSAL YOUR VOTE RECOMMENDS 1. To elect the four nominees of our board of directors, to our board of directors as Class II directors, each to hold office until our Annual Meeting of Shareholders in 2028 and until such director’s successor has been duly elected, or if sooner, until the director’s death, resignation or removal. FOR WITHHOLD 1.01 David Bonita, M.D. FOR #P2

# #P2# 1.02 Thomas Civik FOR #P3# #P3# 1.03 Carol A. Schafer FOR #P4# #P4# 1.04 Steven Stein, M.D. FOR #P5# #P5# FOR AGAINST 2. To approve, on an advisory basis, the compensation of our named executive officers, as disclosed in the FOR accompanying proxy statement. #P6# #P6# FOR WITHHOLD 3. To appoint Ernst & Young LLP as our independent registered public accounting firm for the fiscal year FOR ending December 31, 2025, and to authorize our board of directors to fix Ernst & Young LLP’s #P7# #P7# remuneration. NOTE: To conduct any other business properly brought before the Annual Meeting. You must pre-registerto attend the meeting online and/or participate at www.proxydocs.com/RPTX. Authorized Signatures—Must be completed for your instructions to be executed. Please sign exactly as your name(s) appears on your account. If held in joint tenancy, all persons should sign. Trustees,