Company: SCLXW
Filing Date: 2025-12-05
Form Type: 424B3
Source: 0001193125-25-309798
Chunk: 4

Company: Scilex Holding Co
Filing Date: 2025-12-05
Form: 424B3
Chunk 4
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 If an event of default occurs and is not cured within the specified cure period under the terms of the Loan Agreement, then the Lender has certain remedies under the Loan Agreement, in addition to any remedies provided at law or in equity, including, without limitation, the interest rate of the Loan will increase by an additional 5.0% per annum and the Loan Agreement will terminate automatically with the Lender entitled to foreclose upon or otherwise dispose of the Pledged Securities. The Loan Agreement also contains positive and negative covenants, representations and warranties and indemnification provisions that are customary for transactions of this type. The foregoing summary of the Loan Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Loan Agreement, a copy of which is filed herewith as Exhibit 10.1 and is incorporated herein by reference. Item 2.03. Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant The information set forth under Item 1.01 above relating to the Loan Agreement is incorporated by reference herein. Item 9.01. Financial Statements and Exhibits. (d) Exhibits.

| Exhibit 
 Number  
 10.1    | Description                                                                                                                                                  
 Non-Recourse Loan and Securities Pledge Agreement, dated December 1, 2025, by and between Scilex Holding Company and The St. James Bank & Trust Company Ltd. |
|:--------|:-------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 104     | Cover Page Interactive Data File, formatted in Inline Extensible Business Reporting Language (iXBRL).                                                        |

<div align='center'>2</div>

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

|                        | SCILEX HOLDING COMPANY |                                     |
|                        | By:                    | /s/ Henry Ji                        |
|                        | Name:                  | Henry Ji                            |
| Date: December 5, 2025 | Title:                 | Chief Executive Officer & President |

<div align='center'>3</div>

Exhibit 10.1

<div align='center'>NON-RECOURSE LOAN AND SECURITIES PLEDGE AGREEMENT

BETWEEN

THE ST. JAMES BANK & TRUST COMPANY LTD.

AND

SCILEX HOLDING COMPANY</div>

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