Company: RVRC
Filing Date: 2025-08-13
Form Type: S-1/A
Source: 0001213900-25-075747
Chunk: 8

Company: Revium Rx.
Filing Date: 2025-08-13
Form: S-1/A
Chunk 8
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 (ECM) means a
network of proteins and polysaccharides outside cells that provides structural and biochemical support, especially important in tissue
integrity and tumor progression.

“HPCD Formulation (Hydroxypropyl-β-Cyclodextrin
Formulation) represents a formulation that uses hydroxypropyl-β-cyclodextrin (HPCD), a modified cyclodextrin molecule, to enhance
the solubility, stability, and bioavailability of poorly water-soluble drugs. HPCD encapsulates the active pharmaceutical ingredient
within its hydrophobic cavity, improving its dissolution and systemic absorption while minimizing irritation and toxicity. It is widely
used in injectable, oral, and topical drug delivery systems.

“Hydroxypropyl-Beta-Cyclodextrin (HPCD)
is a water-soluble derivative of cyclodextrin used to improve the solubility and stability of poorly water-soluble drugs.

“Isolates” are Specific strains
of microorganisms (such as bacteria or fungi) that have been cultured and identified, often used in susceptibility testing.

“MRSA (Methicillin-Resistant
Staphylococcus aureus)”is a type of Staphylococcus aureus bacteria that has developed resistance to methicillin
and related antibiotics, making it harder to treat. It can cause a range of infections—from minor skin issues to serious bloodstream,
lung, or surgical site infections. It is commonly acquired in hospitals or community settings.

“MICs (Minimum Inhibitory Concentrations)”
are the lowest concentration of an antimicrobial agent that inhibits visible growth of a microorganism, used to assess bacterial susceptibility.

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“MRSA (Methicillin-Resistant Staphylococcus
aureus)” represents a type of bacteria resistant to many antibiotics, including methicillin, commonly associated with healthcare-
and community-acquired infections.

“Nano-Liposomal Particles (NLP)-based
medicines” are specialized nano-scale lipid vesicles engineered to encapsulate therapeutic agents, enhancing their stability, bioavailability,
and targeted delivery to specific tissues or cells.

“Nano-medicines” refer to pharmaceutical
formulations designed at the nanoscale (typically 1 to 100 nanometers) intended to improve drug delivery, increase therapeutic effectiveness,
and reduce adverse effects.

“Neutropenic Lung Infection is lung