Company: PRTA
Filing Date: 2025-08-08
Form Type: S-8
Source: 0001559053-25-000034
Chunk: 1

Company: PROTHENA CORP PUBLIC LTD CO
Filing Date: 2025-08-08
Form: S-8
Chunk 1
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-8 is not being filed with or included in this Form S-8 (by incorporation by reference or otherwise) in accordance with the rules and regulations of the Securities and Exchange Commission (the “Commission”). This Registration Statement on Form S-8 is filed by Prothena Corporation plc (the “Registrant”) regarding the Prothena Corporation plc 2018 Long Term Incentive Plan, as amended (the “Plan”). Documents containing the information required by Part I of the Registration Statement will be sent or given to participants in the Plan as specified by Rule 428(b)(1) under the Securities Act of 1933, as amended (the “Securities Act”).

PART II. INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

## ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE
The information incorporated by reference herein is considered to be part of this Registration Statement, and later information filed with the Commission will update and supersede this information. The following documents filed by the Registrant with the Commission are incorporated herein by reference:

(a) The Registrant’s Registration Statement on Form 10 (File No. 001-35676) filed with the Commission under Section 12(b) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), on October 1, 2012, including the description of the Registrant’s ordinary shares contained therein, and any amendment or report filed for the purpose of updating such description, including Exhibit 4.2 to the Company’s Annual Report on Form 10-K for the year ended December 31, 2024 and filed with the Commission on February 27, 2025;

(b) The Registrant’s Annual Report on Form 10-K for the year ended December 31, 2024, filed with the Commission on February 27, 2025;

(c) The Registrant’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, filed with the Commission on May 8, 2025;

(d) The Registrant’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2025, filed with the Commission on August 4, 2025; and

(e) The Registrant’s Current Reports on Form 8-K filed with the Commission on May 16, 2025 , May 23, 2025 , June 16, 2025 , June 18, 2025 , July 30,