Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 111

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 111
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 securities or interest therein on behalf of, or with “plan assets” of, any such plan;              |

| (b) | its acquisition, holding and disposition of such securities are not and will not be prohibited because they are                                         
 exempted by one or more of the following prohibited transaction exemptions: PTCE 96-23, 95-60, 91-38, 90-1, 84-14 or the Service Provider Exemption; or |

| (c) | it is a governmental plan (as defined in section 3(32) of ERISA) or other plan that is not subject to the                                                
 provisions of Title I of ERISA or Section 4975 of the Code and its acquisition, holding and disposition of such securities are not otherwise prohibited. |

23

Due to the complexity of these rules and the penalties imposed upon persons involved in prohibited
transactions, it is important that any person considering the acquisition of the offered securities with plan assets consult with its counsel regarding the consequences under ERISA and the Code, or other similar law, of the acquisition and ownership
of offered securities and the availability of exemptive relief under the class exemptions listed above.

The sale of any securities to any plan is in no
respect a representation by Comerica or any of its affiliates or representatives that such an investment is appropriate for or meets all relevant legal requirements with respect to investments by plans generally or any particular plan. Please
consult the applicable prospectus supplement for further information with respect to a particular offering and, in certain cases, further restrictions on the purchase or transfer of securities.

LEGAL MATTERS

The validity of these securities has been passed upon for Comerica by Mayer Brown LLP, Chicago, Illinois. In connection with particular offerings of the
securities in the future, the validity of the securities may be passed upon for Comerica by one of Comerica’s lawyers or other counsel to Comerica named in the applicable prospectus supplement and for underwriters, agents or dealers by Mayer
Brown LLP, Chicago, Illinois. From time to time, Mayer Brown LLP has represented Comerica on various matters and may do so in the future.

EXPERTS

The
consolidated financial statements of Comerica Incorporated incorporated by reference in Comerica Incorporated’s Annual Report (Form 10-K) for the year ended December 31, 2022, and the effectiveness
of Comerica Incorporated’s internal control over financial reporting as of December 31, 2022 have been