Company: SHPH
Filing Date: 2025-01-24
Form Type: 424B3
Source: 0001493152-25-003508
Chunk: 239

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-01-24
Form: 424B3
Chunk 239
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 units (“RSUs”), with a value of $41,840,
with such RSUs vesting in full as of the date of issuance. Each RSU represents the right to receive one share of SHPH common
stock.

On June 13, 2024, the Company’s newly appointed CFO was awarded 28,455restricted stock units (“RSUs”), with a value of $ 100,000, with such RSUs vesting annually in three equal installments following the date of issuance. Each RSU represents the right to receive one share of SHPH common stock.

Alto Opportunity Master Fund, SPC

On July 12, 2024, the Company informed the Investor in the Alto Convertible Note that the Company’s expected restatement of its consolidated financial statements for the years ended December 31, 2022 and 2023 constituted an event of default under the terms of the Alto Convertible Note. On August 6, 2024, the Company paid $ 600,000to the Investor, which funds will be held as collateral to the balance owed under the Alto Convertible Note, and received a waiver from the Investor related to the default.

Alliance Global Partners

On July 30, 2024, the Company
engaged A.G.P./Alliance Global Partners (“AGP”) to serve as exclusive underwriter, placement agent or advisor in
any public or private offering or financing (as defined, the “Offering”) of up to $10million.

| F-46 |

<div align='center'>Up to 1,464,268 Shares of Common Stock Issuable Upon Conversion of 14.5% Senior Secured Convertible Notes

Up to 329,461 Shares of Common Stock Issuable Upon Exercise of Warrants

SHUTTLE PHARMACEUTICALS HOLDINGS, INC.

PROSPECTUS

January 23,2025</div>