Company: CF
Filing Date: 2025-11-19
Form Type: 424B2
Source: 0001104659-25-113972
Chunk: 81

Company: CF Industries Holdings, Inc.
Filing Date: 2025-11-19
Form: 424B2
Chunk 81
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S-52</div>

TABLE OF CONTENTS

### PROSPECTUS

#### CF INDUSTRIES HOLDINGS, INC.

#### Common Stock

#### Preferred Stock

#### Depositary Shares

#### Debt Securities
<div align='center'>**Guarantees of Debt Securities of CF Industries, Inc.**</div>

#### Warrants

#### Stock Purchase Contracts

#### Stock Purchase Units

#### CF INDUSTRIES, INC.

#### Debt Securities
**You should read this prospectus and the applicable prospectus supplement carefully before you invest in any offered securities.

CF Industries Holdings, Inc. (“CF Holdings”) may offer and sell the securities identified above under its name, from time to time, in one or more offerings. CF Industries, Inc. (“CF Industries”) may offer and sell debt securities, which will be fully and unconditionally guaranteed by CF Holdings, from time to time, in one or more offerings. This prospectus provides you with a general description of the securities. The applicable prospectus supplement will contain the specific terms of the securities being offered thereby.

CF Holdings and CF Industries may sell these securities to or through underwriters, dealers or agents or directly or through their subsidiaries to purchasers.

CF Holdings’ common stock is listed on the New York Stock Exchange under the trading symbol “CF.” Each prospectus supplement will indicate if the securities offered thereby will be listed on any securities exchange.

Investing in these securities involves risks. See “Risk Factors” on page 3of this prospectus, as well as any risk factors contained in any prospectus supplement and the documents incorporated by reference herein and therein, before you make your investment decision.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus or any prospectus supplement is truthful or complete. Any representation to the contrary is a criminal offense.**

<div align='center'>The date of this prospectus is November 6, 2025.</div>

TABLE OF CONTENTS

TABLE OF CONTENTS

| ​                                   | ​ | ​ | Page |   |    |   | ​ |
| About this Prospectus               | ​ | ​ | ​    | ​ |  1 | ​ | ​ |
| The Company                         | ​ | ​ | ​    | ​ |  2 | ​ | ​ |
| Risk Factors                        | ​ | ​ | ​    | ​ |  3 | ​ | ​ |
| Forward-Looking Statements          | ​ | ​ | ​