Company: MDCXW
Filing Date: 2025-11-19
Form Type: S-1
Source: 0001062993-25-016962
Chunk: 118

Company: Medicus Pharma Ltd.
Filing Date: 2025-11-19
Form: S-1
Chunk 118
---
 µg of doxorubicin or from mice receiving 200 µg D-MNA, after 5, 20, and 60 minutes. Doxorubicin content of the blood samples was measured by spectrofluorimetry and quantitated against a calibration curve. No detectable quantities of doxorubicin were observed in the mice receiving the 200 µg D-MNA; doxorubicin levels were detectable in the intravenously injected mice.

<div align='center'>80

Figure 11.</div>

In addition, Medicus obtained pharmacokinetic data during the Yucatan minipig local tolerance study (Study No. S15055). A total of 30 minipigs (15 males and 15 females) were randomized into five treatment groups. Groups of 3 males and 3 females were treated with a blank control array (Group 1), and three dose levels of D-MNA at 25, 50 and 200 µg/dose of doxorubicin hydrochloride (Groups 2 - 4), respectively. An intravenous ("IV") doxorubicin group consisting of 3 males and 3 females served as a reference control (Group 5). Dosing occurred on Days 1, 7 and 14 with either control array or test article (Groups 1-4), and Group 5 was dosed IV on these same study days. Each topical treatment was 30 minutes. The experimental design is provided in the table below.

Study Design of Minipig Local Tolerance Study

| Group |     | Treatment         |     | Treatment/Dose |     |                                      |     | Number of Animals |     |   |     | Dose Route/       
 Frequency         |
| Array |     | Dosage (µg/dose)  |     |           Male |     |                               Female |     |                   |     |   |     |                   |
| 1     |     | Blank Control     |     |              1 |     |                                    0 |     |                 3 |     | 3 |     | MNA/Days 1, 7, 14 |
| 2     |     | D-MNA-low         |     |              1 |     |                                   25 |     |                 3 |     | 3 |     |                   |
| 3     |     | D-MNA-mid         |     |              1 |     |                                   50 |