Company: RGNT
Filing Date: 2025-07-07
Form Type: F-1/A
Source: 0001213900-25-061821
Chunk: 116

Company: REGENTIS BIOMATERIALS LTD.
Filing Date: 2025-07-07
Form: F-1/A
Chunk 116
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 technology to broaden our product base. Our Gelrin family of products is a unique one that can be used for other 
 injuries and we intend to develop a pipeline of products that can be used for additional tissue regeneration opportunities.      |

Our Solution – Cartilage Regeneration Through Stimulating the Body’s Natural healing Process

Gelrin is a family of hydrogels
that derive their unique physical and chemical properties from polymer chains crosslinked with trace quantities of denatured protein.
In the body, Gelrin is eroded and resorbed over time through a pre-programmed and controlled gradual surface degradation process, meaning
that the GelrinC implant covers the entire wound, so the cells that naturally want to migrate to the damaged tissue in situations where
there is nothing holding them back or preventing them from migration, are unable to migrate due to the GelrinC implant and are controlled,
which allows for the receding implant to allow the surrounding cells to regenerate the cartilage in a controlled and synchronous process.
The body of this receding mass acts to stimulate the body’s natural healing process, by guiding the migration and organization
of cells involved in tissue repair doing so in a gradual process over time. Gelrin is applied in liquid form allowing it to completely
fill the entire tissue defect and is then cured into a rubbery implant by the use of ultraviolet, or UV, light. It can be introduced
into narrow bone crevices or large spaces, open or closed.

GelrinC is specifically designed
for the repair of articular cartilage defects in the knee caused by acute trauma or repetitive use. It is delivered directly to fill
the injury site using a delivery device, Stelar, which seals the lesion during the procedure, and through which the GelrinC liquid is
delivered, and from which the curing UV light is projected. Once the liquid GelrinC has filled the defect, it is cured in place into
an elastomeric implant by photo-curing under UV light for 90 seconds. The implant then starts eroding in conjunction with the advancing
cartilage tissue from the outside edges of the lesion inward. Following a period of approximately six to nine months, the implant is
completely eroded, resorbed and the injury’s surface is covered by newly formed hyaline-like cartilage produced by the patient’s
own body. The primary mode of action of GelrinC is presenting a smooth, impenetrable, neutral surface to the reproduced cartilage cells.
The