Company: BWAY
Filing Date: 2025-04-22
Form Type: 20-F
Source: 0001171843-25-002347
Chunk: 126

Company: Brainsway Ltd.
Filing Date: 2025-04-22
Form: 20-F
Item: Item 5
Chunk 126
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3 days (±0.2).

Figure 5. OCD Durability and Reduction
in Unproductivity

  72  

Deep TMS for
Smoking Addiction

Disease
Overview

Smoking is one of the leading
causes of death in developed countries. The addiction to nicotine, similar to the addiction to drugs and alcohol, activates the limbic
system and causes uncontrollable desire to smoke. According to the World Health Organization (WHO), 1.3 billion people globally use tobacco,
primarily cigarette smoking. Globally, more than 8 million people die from smoking each year: 7 million from direct use and 1.2 million
from second-hand smoke. Approximately 34 million U. S. adults smoke cigarettes, and 480,000 die from smoking each year. Repeated nicotine
use leads to tobacco use disorder (TUD), characterized by craving and withdrawal, compulsive use despite negative consequences, repeated
relapses, and is associated with multiple health problems and failed attempts to cease. Smoking causes about 90% of all lung cancer deaths.

Market
Information

The global nicotine replacement therapy (NRT) market
was estimated at $2.6 billion in 2019, and this market value is anticipated to increase as a result of the increasing incidence of chronic,
smoking-related diseases. Chantix (Varenicline), the leading smoking cessation pharmaceutical from Pfizer, had sales of $1.1 billion worldwide
in 2019, $899 million from the United States. Considering the U. S. market, there are 34 million cigarette smokers. Each year, 55% attempt
to quit smoking (81% of which are motivated to quit). Only 29% of adult smokers that attempt to quit report using medication (e. g. NRT,
Varenicline, Buproprion), and less than 10% of smokers quit within a given year with varied long-term success.

Treatment
Options for Smoking Addiction

One of the most common smoking
addiction options is nicotine replacement therapy (NRT), which is the affixing of patches to the body or the chewing of gum which secrete
decreasing concentrations of nicotine in a manner which may assist physical withdrawal. However, this method does not treat the psychological-behavioral
component of the addiction, and therefore there is a high probability that the patient will return to smoking if nicotine patch treatment
is discontinued. A study found that 93% of over-the-counter