Company: SPRB
Filing Date: 2025-03-31
Form Type: NT 10-K
Source: 0000950170-25-047912
Chunk: 1

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-03-31
Form: NT 10-K
Chunk 1
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 will be filed on or before the fifteenth calendar day following the prescribed due date; or the subject quarterly report or transition report on Form 10-Q or subject distribution report on Form 10-D, or portion thereof, will be filed on or before the fifth calendar day following the prescribed due date; and |                                                                                                                                    |
|   | -c |    | The accountant’s statement or other exhibit required by Rule 12b-25(c) has been attached if applicable.                                                                                                                                                                                                                                                                                                                                                                 |                                                                                                                                    |

# PART III — NARRATIVE
State below in reasonable detail why Forms 10-K, 20-F, 11-K, 10-Q, 10-D, N-CEN, N-CSR, or the transition report or portion thereof, could not be filed within the prescribed time period.

Spruce Biosciences, Inc. (the “Company”) is unable to timely file with the Securities and Exchange Commission (“SEC”) its Annual Report on Form 10-K for the year ended December 31, 2024 (the “2024 Annual Report”) without unreasonable effort or expense by the March 31, 2025 filing deadline applicable to non-accelerated filers, due to a delay experienced by the Company in completing certain required disclosures in the 2024 Annual Report.

The Company is working diligently to finalize the 2024 Annual Report and expects to file the 2024 Annual Report with the SEC as soon as practicable, and no later than the fifteenth calendar day following the prescribed due date, in accordance with Rule 12b-25.

# PART IV — OTHER INFORMATION
| (1) |     | Name and telephone number of person to contact in regard to this notification                                                                                                                                                                                                                                                               |     |            |     |                   |
|     |     | Samir Gharib                                                                                                                                                                                                                                                                                                                                |     |       -415 |     | 655-4168          |
|     |     | -Name                                                                                                                                                                                                                                                                                                                                       |     | -Area Code |     | -Telephone Number |
| (2) |     | Have all other periodic reports required under Section 13 or 15(d) of the Securities Exchange Act of 1934 or Section 30 of the Investment Company Act of 1940 during the preceding 12 months or for such shorter period that the registrant was required to file such report(s) been filed? If answer is no, identify report(s). Yes ☒ No ☐ |     |            |