Company: TEM
Filing Date: 2025-03-07
Form Type: 424B3
Source: 0001193125-25-049935
Chunk: 65

Company: Tempus AI, Inc.
Filing Date: 2025-03-07
Form: 424B3
Chunk 65
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 pursuant to this prospectus. The selling stockholder will bear all commissions and discounts, if any, attributable to its sale of securities. We will not receive any of the proceeds from the sale of the securities by the selling stockholder. The aggregate proceeds to the selling stockholder will be the purchase price of the securities less any discounts and commissions borne by the selling stockholder. The shares of Class A common stock owned by the selling stockholder covered by this prospectus may be offered, sold, transferred or otherwise disposed of from time to time by the selling stockholder. The selling stockholder will act independently of us in making decisions with respect to the timing, manner and size of each sale. Such sales may be made on one or more exchanges, markets, trading facilities or in the over-the-countermarket or otherwise, at fixed prices, at prevailing market prices at the time of sale, at prices related to the prevailing market price, at varying prices determined at the time of sale or at negotiated prices. The selling stockholder may sell or otherwise dispose of their securities by one or more of, or a combination of, the following methods:

| • |     | through one or more underwriters in a public offering, pursuant to which underwriters may resell the shares in                                       
 one or more transactions, including in negotiated transactions at a fixed public offering price or at varying prices determined at the time of sale; |

| • |     | purchases by a broker-dealer as principal and resale by such broker-dealer for its own account pursuant to 
 this prospectus;                                                                                           |

| • |     | ordinary brokerage transactions and transactions in which the broker solicits purchasers; |

| • |     | transactions in which the broker-dealer solicits purchasers on a best efforts basis; |

| • |     | block trades in which the broker-dealer so engaged will attempt to sell the shares as agent but may position 
 and resell a portion of the block as principal to facilitate the transaction;                                |

| • |     | an over-the-counter                                                   
 distribution in accordance with the rules of the Nasdaq Stock Market; |

| • |     | through trading plans entered into by a selling stockholder pursuant to Rule                                                                                                                                     
 10b5-1 under the Exchange Act, that are in place at the time of an offering pursuant to this prospectus and any applicable prospectus supplement hereto that provide for periodic sales of its securities on the 
 basis of parameters described in such trading plans;                                                                                                                                                             |

| • |     | short sales