Company: EDSA
Filing Date: 2025-09-09
Form Type: 424B5
Source: 0001171843-25-005799
Chunk: 17

Company: Edesa Biotech, Inc.
Filing Date: 2025-09-09
Form: 424B5
Chunk 17
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 fully vested restricted stock units; |

| · | 1,150,607 of our common shares issuable upon conversion of unvested restricted stock units; |

| · | 668,398 of our common shares available for issuance or future grant pursuant to our equity incentive plan; |

| · | 435,414 of our common shares issuable upon the conversion of our Series A-1 Convertible Preferred Shares; |

| · | 4,343,750 of our common shares issuable upon the conversion of our Series B-1 Convertible Preferred Shares; and |

| · | 934,590 of our common shares issuable upon exercise of outstanding warrants at a weighted average 
 exercise price of $15.35 per share.                                                               |

To the extent that outstanding exercisable options or warrants are exercised, you may experience
further dilution. In addition, we may need to raise additional capital and to the extent that we raise additional capital by issuing equity
or convertible debt securities your ownership will be further diluted.

| S-11 |

### CERTAIN TAX MATTERS
THE FOLLOWING SUMMARY IS OF A GENERAL
NATURE ONLY AND IS NOT INTENDED TO BE, NOR SHOULD IT BE CONSTRUED TO BE, LEGAL OR TAX ADVICE TO ANY PARTICULAR INVESTOR. CONSEQUENTLY,
PROSPECTIVE INVESTORS ARE URGED TO CONSULT THEIR OWN TAX ADVISORS FOR ADVICE AS TO THE TAX CONSEQUENCES OF AN INVESTMENT IN THE SECURITIES
OFFERED BY THIS PROSPECTUS SUPPLEMENT AND THE ACCOMPANYING PROSPECTUS HAVING REGARD TO THEIR PARTICULAR CIRCUMSTANCES.

**Material U.S. Federal Income Tax Considerations for U.S. Holders**

The following discussion is a summary
of the material U.S. federal income tax consequences applicable to the purchase, ownership and disposition of common shares being offered
by this prospectus supplement and the accompanying prospectus by a U.S. Holder (as defined below), but does not purport to be a complete
analysis of all potential U.S. federal income tax effects.

This summary is based on the Internal
Revenue Code of 1986, as amended (the “Code”), final temporary and proposed U.S. Treasury regulations promulgated thereunder
(the “Regulations”), IRS rulings and judicial decisions in effect on the date of this prospectus supplement. All of these
are subject to change, possibly with retroactive effect, or different interpretations. This summary