Company: APXIF
Filing Date: 2025-07-03
Form Type: F-4/A
Source: 0001213900-25-061545
Chunk: 367

Company: APx Acquisition Corp. I
Filing Date: 2025-07-03
Form: F-4/A
Chunk 367
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 nutrition recommendations and habit plans that support informed life changes that would mitigate disease initiation and development and improve overall wellbeing. Rewell’s proprietary platform provides personalized DNA and microbiome results by integrating customer’s genetic and lifestyle data and associated risk factors and comparing these results to both a standard and proprietary database. This aims at lowering the chances of developing low grade chronic inflammation over time, as Rewell provides insights from personal genomic information and their impact on and long -termhabits. According to the research paper titled “Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort”, published in Nature Genetics on February3, 2022, diets and environmental factors have a greater influence on the human gut microbiome than host genetics. Given these results, to provide accurate and relevant insights that account for geographical influences, we based the gut microbiome results provided by Rewell on a proprietary database constructed through patient trials tailored to the geography where the services are offered. This reference database was constructed through a citizen science initiative conducted from December 2015 through December 2016, which recruited 200 volunteers with healthy habits as a reference data database for human gut microbiome analysis. These volunteers were from various rural and urban areas in Argentina, who were recruited, compiled, and analyzed by Heritas Argentina and CIBIC as an open citizen science project. Volunteers were instructed about the project and directed to four partner clinical labs in the different cities participating in the project for sample collection and signing an informed consent. In the screening phase, individuals who did not meet the established inclusion or exclusion criteria were excluded from participation. The sample inclusion criteria specified that participants must be adults, either male or female, aged between 18 and 50 years. They were required to undergo a physical examination that revealed no clinically relevant findings. Additionally, participants needed to have non -reactiveserology tests for Hepatitis B Virus surface antigen (HBsAg), antibodies against human immunodeficiency virus (anti -HIV), and Hepatitis C Virus antibodies (anti -HCV). Female volunteers were required to have a negative blood pregnancy test, and all participants needed to be capable of reading, understanding, and signing an informed consent form. 182 The sample exclusion criteria outlined several conditions for disqualification. Participants were excluded if they suffered from gastrointestinal disorders, such as chronic intestinal inflammation, ulcerative colitis, Crohn’s disease, indeterminate colitis, moderate to severe irritable colon syndrome, infectious gastroenteritis, colitis, or gastritis. Chronic or persistent