Company: INMB
Filing Date: 2025-06-30
Form Type: 424B5
Source: 0001213900-25-059298
Chunk: 1

Company: Inmune Bio, Inc.
Filing Date: 2025-06-30
Form: 424B5
Chunk 1
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 UNITS                                      |     |   10 |
| PLAN OF DISTRIBUTION                                      |     |   10 |
| EXPERTS                                                   |     |   13 |
| WHERE YOU CAN FIND MORE INFORMATION                       |     |   13 |
| INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE           |     |   14 |

<div align='center'>S-i

ABOUT THIS PROSPECTUS SUPPLEMENT</div>

On May 1, 2024, we filed with
the SEC a registration statement on Form S-3 (File No. 333-79036) (the “Registration Statement”) utilizing a shelf registration
process relating to the securities described in this prospectus supplement, which Registration Statement was amended on August 2, 2024
and declared effective on August 7, 2024. Under this shelf registration process, we may, from time to time, sell up to $250 million in
the aggregate of shares of common stock, shares of preferred stock, warrants and units. Approximately $162 million remains available for
sale as of the date of this prospectus supplement (excluding the shares offered hereby). This prospectus supplement is part of the Registration
Statement using a “shelf” registration process to register sales of our securities, under the Securities Act of 1933, as amended,
or the Securities Act.

This document consists of
two parts. The first part is this prospectus supplement, including the documents incorporated by reference, which describes the specific
terms of this offering. The second part is the accompanying prospectus filed with the SEC as part of the Registration Statement, including
the documents incorporated by reference, that gives more general information, some of which may not apply to this offering. Generally,
when we refer only to the “prospectus,” we are referring to both parts combined. This prospectus supplement may add to, update
or change information in the accompanying prospectus and the documents incorporated by reference into this prospectus supplement or the
accompanying prospectus.

This prospectus supplement,
the accompanying prospectus and the documents incorporated in each by reference include important information about us, the shares being
offered and other information you should know before investing in our common stock. To the extent there is a conflict between the information
contained in this prospectus supplement, on the one hand, and the information contained in any document incorporated by reference into
this prospectus supplement that was filed with the SEC before the date of this prospectus supplement, on the