Company: SPRB
Filing Date: 2025-10-29
Form Type: S-3
Source: 0001193125-25-256668
Chunk: 3

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-10-29
Form: S-3
Chunk 3
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 the registration of the Shares. See the section titled “Plan of Distribution” for more information about how the selling stockholders may sell or dispose of their Shares.

Our common stock is traded on the Nasdaq Capital Market under the symbol “SPRB.” On October 28, 2025, the last reported sales price of our common stock was $124.51 per share.

We are an “emerging growth company” as defined by the Jumpstart Our Business Startups Act of 2012, and as such, have elected to comply with reduced public company reporting requirements for this prospectus and the documents incorporated by reference herein and may elect to comply with reduced public company reporting requirements in future filings.

Investing in our securities involves a high degree of risk. Before making an investment decision, you should review carefully the risks and uncertainties described under the heading “Risk Factors” on page6of this prospectus as well as those contained in the applicable prospectus supplement and in any free writing prospectuses we may authorize for use in connection with a specific offering, and under similar headings in the other documents that are incorporated by reference into this prospectus.

NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

The date of this prospectus is , 2025.

TABLE OF CONTENTS

|                                                        | Page |
| ABOUT THIS PROSPECTUS                                  |    i |
| PROSPECTUS SUMMARY                                     |    1 |
| THE OFFERING                                           |    5 |
| RISK FACTORS                                           |    6 |
| SELECTED FINANCIAL DATA REFLECTING REVERSE STOCK SPLIT |    7 |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS      |    9 |
| USE OF PROCEEDS                                        |   10 |
| SELLING STOCKHOLDERS                                   |   11 |
| PLAN OF DISTRIBUTION                                   |   15 |
| LEGAL MATTERS                                          |   17 |
| EXPERTS                                                |   17 |
| WHERE YOU CAN FIND MORE INFORMATION                    |   17 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE      |   17 |

This prospectus is a part of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission