Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 100

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 100
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 any omission to comply with such obligations will not constitute an event of default. Discharge under these procedures is called “covenant defeasance”. Defeasance or covenant defeasance may be effected only if, among other things:

| • |     | Comerica irrevocably deposits with the trustee cash or U.S. government obligations, as trust funds in an amount                                                                                                                                     
 certified to be sufficient to pay on each date that they become due and payable, the principal of, interest on, other amounts due under, and any mandatory sinking fund payments for, all outstanding debt securities of the series being defeased; |

| • |     | No event of default or covenant breach with respect to such series of debt securities has occurred and is                                                                                                   
 continuing and, with respect to subordinated debt securities, no event of default or covenant breach with respect to Senior Indebtedness has occurred and is continuing and which permits acceleration; and |

| • |     | Comerica delivers to the trustee an opinion of counsel to the effect that: |

| • |     | the beneficial owners of the series of debt securities being defeased will not recognize income, gain or loss for 
 United States federal income tax purposes as a result of the defeasance or covenant defeasance; and               |

| • |     | the defeasance or covenant defeasance will not otherwise alter those beneficial owners’ United States                                       
 federal income tax treatment of principal or interest payments or other amounts due under the series of debt securities being defeased; and |

| • |     | in the case of a defeasance, this opinion must be based on a ruling of the Internal Revenue Service or a change                               
 in United States federal income tax law occurring after the date of this prospectus, since that result would not occur under current tax law. |

Modification of the Indenture; Waiver of Compliance Each indenture contain provisions permitting Comerica and the trustee to modify the indenture or the rights of the holders of debt securities with the consent of the holders of not less than a majority in principal amount of each outstanding series of debt securities affected by the modification. Each holder of an affected debt security must consent to a modification that would:

| • |     | change the stated maturity date of the principal of, or of any installment of principal of or interest on, any 
 debt security;                                                                                                 |

| • |     | reduce the principal amount of, interest on, or any other amounts due under any debt security;