Company: SUPN
Filing Date: 2025-07-31
Form Type: SC TO-T/A
Source: 0001104659-25-072515
Chunk: 3

Company: SUPERNUS PHARMACEUTICALS, INC.
Filing Date: 2025-07-31
Form: SC TO-T/A
Chunk 3
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 12. Exhibits.

Item 12 of the Schedule TO is hereby amended and supplemented by adding
the following exhibit thereto:

| Index No. |                                                                                                                                                                                                                    |
| (a)(5)(D) | Press Release, issued by Supernus Pharmaceuticals, Inc., on July 31, 2025 (incorporated by reference to Exhibit 99.1 to the Current Report to Form 8-K filed by Supernus Pharmaceuticals, Inc., on July 31, 2025). |

<div align='center'>SIGNATURES</div>

After due inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and correct.

Dated: July 31, 2025

| SAPHIRE, INC.                  |                                       |
| By:                            | /s/ Jack A. Khattar                   |
| Name:                          | Jack A. Khattar                       |
| Title:                         | President and Treasurer               |
| SUPERNUS PHARMACEUTICALS, INC. |                                       |
| By:                            | /s/ Jack A. Khattar                   |
| Name:                          | Jack A. Khattar                       |
| Title:                         | President and Chief Executive Officer |