Company: SNY
Filing Date: 2025-10-27
Form Type: 424B5
Source: 0001193125-25-250786
Chunk: 99

Company: Sanofi
Filing Date: 2025-10-27
Form: 424B5
Chunk 99
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 must look to your own bank or broker for payments on the securities and                   
 protection of your legal rights relating to the securities, as explained above under “Street Name and Other Indirect Holders.” |

| • |     | you may not be able to sell interests in the debt securities to some insurance companies and other institutions 
 that are required by law to own their securities in the form of physical certificates.                          |

| • |     | the depositary’s policies will govern payments, transfers, exchange and other matters relating to your                                                                                                                                             
 interest in the global security. We and the trustee have no responsibility for any aspect of the depositary’s actions or for its records of ownership interests in the global security. We and the trustee also do not supervise the depositary in 
 any way.                                                                                                                                                                                                                                           |

| • |     | the depositary will require that indirect interests in the global security be purchased or sold within its system 
 using same-day funds for settlement.                                                                              |

Special Situations in Which a Global Security is Exchangeable for Physical Certificates In a few special situations described below, a global security is exchangeable for physical certificates representing securities. After that exchange, the choice of whether to hold securities directly or in street name will be up to the investor. Investors must consult their own bank or brokers to find out how to have their interests in securities transferred to their own name so that they will be direct Holders. The rights of street name investors and direct Holders in the securities have been previously described in the subsections entitled “—Street Name and Other Indirect Holders” and “—Direct Holders” above. The special situations in which a global security is exchangeable for physical certificates are:

| • |     | When the depositary notifies us that it is unwilling, unable or no longer qualified to continue as depositary and 
 we do not appoint a successor depositary within 90 days.                                                          |

| • |     | When we elect to exchange the global securities representing such debt securities for physical certificates 
 representing such debt securities.                                                                          |

| • |     | When an event of default on the securities has occurred and has not been cured. Defaults on debt securities are  
 discussed under “Description of Debt Securities We May Offer — Default and Related Matters — Events of Default”. |

The prospectus supplement(s) may also list additional situations for terminating a global security that would apply only to the particular series of securities covered by the prospectus supplement. When a global security terminates, neither the depositary, nor we, nor the