Company: CMA
Filing Date: 2025-10-06
Form Type: 425
Source: 0001193125-25-230871
Chunk: 7

Company: COMERICA INC
Filing Date: 2025-10-06
Form: 425
Chunk 7
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 No offer of securities shall be made
except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended.

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

| Date: October 6, 2025 |     | COMERICA INCORPORATED |     | /s/ Von E. Hays                     |
|:----------------------|:----|:----------------------|:----|:------------------------------------|
|                       |     |                       |     | Von E. Hays                         |
|                       |     |                       |     | Senior Executive Vice President and |
|                       |     |                       |     | Chief Legal Officer                 |

Exhibit 99.1

Monday, October 6, 2025 Fifth Third to Acquire Comerica Merger Delivers Compelling Value to Shareholders CINCINNATI and DALLAS—Fifth Third Bancorp (Nasdaq: FITB) and Comerica Incorporated (NYSE: CMA) today announced that they have entered into a definitive merger agreement under which Fifth Third will acquire Comerica in an all-stocktransaction valued at $10.9 billion. Under the terms of the agreement, Comerica’s stockholders will receive 1.8663 Fifth Third shares for each Comerica share, representing $82.88 per share as of Fifth Third’s closing stock price on October 3, 2025, and a 20% premium to Comerica’s 10-dayvolume-weighted average stock price. At close, Fifth Third shareholders will own approximately 73% and Comerica shareholders will own approximately 27% of the combined company. This transaction brings together two long-tenured banking franchises to create the 9 thlargest U.S. bank with approximately $288 billion in assets. The combination is expected to be immediately accretive to shareholders; deliver peer-leading efficiency, return on assets and return on tangible common equity ratios; and create a compelling platform to generate sustainable long-term growth. The acquisition is a strategic acceleration of Fifth Third’s long-term growth plan, enhancing scale, profitability, and geographic reach. The combination of Fifth Third’s award-winning retail banking and digital capabilities with Comerica’s strong middle market banking franchise and attractive footprint further strengthens Fifth Third’s position in high-growth markets. The combined