Company: APM
Filing Date: 2025-10-14
Form Type: 424B5
Source: 0001213900-25-098635
Chunk: 2

Company: Aptorum Group Ltd
Filing Date: 2025-10-14
Form: 424B5
Chunk 2
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 Aptorum and its consolidated subsidiaries
collectively.

Investing in these securities involves a high degree of risk. Before buying any securities, you should carefully read the discussion of material risks of investing in our securities in “Risk Factors” beginning on page 34 of this prospectus supplement.

The information contained or incorporated in this prospectus or in any prospectus supplement is accurate only as of the date of this prospectus, or such prospectus supplement, as applicable, regardless of the time of delivery of this prospectus or any sale of our securities.

Investing in our securities being offered pursuant to this prospectus involves a high degree of risk. You should carefully read and consider the ‘‘Risk Factors’’ section of this prospectus, and risk factors set forth in our most recent annual report on Form 20-F, in other reports incorporated herein by reference,and in the applicable prospectus supplement before you make your investment decision.

Neither the Securities and Exchange Commission, the Cayman Islands Monetary Authority, nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

|                                  |     | Per              
 Class A Ordinary 
 Share            |      |     | Total |           |
| Offering price                   |     | US$              | 2.00 |     | US$   | 2,000,000 |
| Placement Agent’s Fees (1)       |     | US$              | 0.14 |     | US$   |   140,000 |
| Proceeds to us (before expenses) |     | US$              | 1.86 |     | US$   | 1,860,000 |

| (1) | We have agreed to pay the Placement Agent a cash fee equal to 7.0% of the aggregate gross proceeds of this offering. We will also pay the Placement Agent in connection with this offering a management fee equal to 1.0% of the gross proceeds raised in the offering, $5,000 for non-accountable expenses, $50,000 for expenses of legal counsel and other out-of-pocket expenses and $10,000 for clearing fees. In addition, we have agreed to issue the Placement Agent warrants (the “Placement Agent Warrants”) to purchase Class A Ordinary Shares equal to 6.0% of the aggregate number of the Class A Ordinary Shares sold in this offering. See “Plan of Distribution” for additional information regarding total compensation payable to the