Company: FITBI
Filing Date: 2025-11-05
Form Type: S-4
Source: 0001193125-25-267273
Chunk: 160

Company: FIFTH THIRD BANCORP
Filing Date: 2025-11-05
Form: S-4
Chunk 160
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 the mergers.

In light of the foregoing, and taking into account that the Fifth Third special meeting and the Comerica special meeting will be held months after the
prospective financial information was prepared, as well as the uncertainties inherent in any forecasted information, Fifth Third shareholders and Comerica stockholders are strongly cautioned not to place unwarranted reliance on such information, and
Fifth Third and Comerica urge all Fifth Third shareholders and Comerica stockholders to review Fifth Third’s and Comerica’s respective most recent SEC filings for descriptions of Fifth Third’s and Comerica’s respective
reported financial results and the financial statements of Fifth Third and Comerica incorporated by reference in this joint proxy statement/prospectus. See the section entitled “Where You Can Find More Information” in the forepart
of this joint proxy statement/prospectus.

The prospective financial information summarized in this section is not being included in this joint proxy
statement/prospectus in order to induce any Fifth Third shareholder to vote in favor of the Fifth Third share issuance proposal or any other proposal to be voted on at the Fifth Third special meeting nor to induce any Comerica stockholder to vote in
favor of the Comerica merger proposal or any of the other proposals to be voted on at the Comerica special meeting.

Interests of Certain Fifth Third Directors and Executive Officers in the First Merger

In considering the recommendation of the Fifth Third board of directors to vote to approve the Fifth Third stock issuance proposal, Fifth Third voting
shareholders should be aware that the directors and executive officers of Fifth Third may have interests in the first merger that are different from, or in addition to, the interests of holders of Fifth Third common stock or Fifth Third preferred
shares generally and that may create potential conflicts of

107

interest. The Fifth Third board of directors was aware of these interests and considered them, among other matters, in evaluating and negotiating the merger agreement and approving the merger agreement, and in recommending to holders of Fifth Third common stock that they vote to approve the Fifth Third merger proposal. For more information, see the sections entitled “ The Mergers — Background of the Mergers” beginning on page 79 and “ The Mergers — Fifth Third’s Reasons for the Mergers; Recommendation of Fifth Third’s Board of Directors” beginning on page 79. These interests are described in more detail below. Fifth Third’s Executive Officers and Directors For purposes of this joint proxy statement/prospectus, Fifth Third’s