Company: MIRM
Filing Date: 2025-09-09
Form Type: S-8
Source: 0001759425-25-000045
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Company: Mirum Pharmaceuticals, Inc.
Filing Date: 2025-09-09
Form: S-8
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<div align='center'>As filed with the Securities and Exchange Commission on September 9, 2025</div>

#### Registration No. 333-
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### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549
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#### FORM S-8

### REGISTRATION STATEMENT

#### UNDER

#### THE SECURITIES ACT OF 1933
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#### Mirum Pharmaceuticals, Inc.
<div align='center'>(Exact name of registrant as specified in its charter)

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| Delaware                                                       |     |                          83-1281555 |
| (State or other jurisdiction of incorporation or organization) |     | -I.R.S. Employer Identification No. |
| 989 East Hillsdale Boulevard, Suite 300                        
 Foster City, California                                        |     |                               94404 |
| (Address of Principal Executive Offices)                       |     |                           -Zip Code |

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#### 2020 Inducement Plan
<div align='center'>(Full titles of the plans)

______________________________________________________________________________________________________________</div>

#### Christopher Peetz

#### Chief Executive Officer

#### Mirum Pharmaceuticals, Inc.

#### 989 East Hillsdale Boulevard

#### Suite 300

#### Foster City, California 94404 (650) 667-4085
<div align='center'>(Name, address, including zip code, and telephone number, including area code, of agent for service)

______________________________________________________________________________________________________________

Copies to:</div>

#### Jason L. Kent

#### Julia R. Boesch

#### Cooley LLP

#### 55 Hudson Yards

#### New York, New York
<div align='center'>(212) 479-6000

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Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer |     | ☒ |     | Accelerated filer         |     | ☐ |
|