Company: PRME
Filing Date: 2025-07-14
Form Type: DEF 14A
Source: 0001193125-25-158716
Chunk: 4

Company: Prime Medicine, Inc.
Filing Date: 2025-07-14
Form: DEF 14A
Chunk 4
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 that appears on your proxy card. Copies of the proxy materials will be mailed to all stockholders of record entitled to notice of, and to vote at, the Special Meeting, and will also be available on the website of the Securities and Exchange Commission (the “SEC”) atwww.sec.gov.

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INFORMATION ABOUT THE SPECIAL MEETING AND VOTING Purposes of the Special Meeting The purposes of the Special Meeting are:

| 1. | To approve the repricing of certain outstanding stock options that have been granted under the                                                                                                                                     
 Company’s 2019 Stock Option and Grant Plan (as may be amended, restated or otherwise modified from time to time in accordance with its terms, the “2019 Plan”) and/or the 2022 Stock Option and Incentive Plan (as may be amended, 
 restated or otherwise modified from time to time in accordance with its terms, the “2022 Plan”) (the “Option Repricing Proposal” or “Proposal 1”);                                                                                 |

| 2. | To approve a proposal to adjourn the Special Meeting to a later date, if necessary or appropriate, to permit                                                                                                                                
 further solicitation and vote of additional proxies in the event that there are insufficient votes for, or otherwise in connection with, the approval of the Option Repricing Proposal at the time of the Special Meeting (the “Adjournment 
 Proposal” or “Proposal 2”); and                                                                                                                                                                                                             |

| 3. | To transact such other business as may properly come before the Special Meeting or any continuations, 
 adjournments, and postponements thereof.                                                              |

Stockholders Entitled to Vote at the Special Meeting Our Board has established the close of business on July 9, 2025 as the “record date” for the Special Meeting. This means that you are entitled to notice of, and to vote, at the Special Meeting (and any continuations, adjournments and postponements thereof) if our records show that you owned our common stock at that time. As of the record date,134,496,013 shares of our common stock were issued and outstanding. Each issued and outstanding share of common stock as of the record date is entitled to one vote on each matter properly to come before the Special Meeting and can be voted only if the record owner of that share, determined as of the record date, votes during the live webcast of the meeting or is represented by proxy. A list of stockholders entitled to vote at the Special Meeting will be available for inspection