Company: PSTV
Filing Date: 2025-04-23
Form Type: S-3/A
Source: 0001193125-25-091456
Chunk: 37

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-23
Form: S-3/A
Chunk 37
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 controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. II-5

SIGNATURES Pursuant to the requirements of the Securities Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Houston, State of Texas, on April 23, 2025.

| PLUS THERAPEUTICS, INC. |     |                                       |
| By:                     |     | /S/ Marc H. Hedrick                   |
|                         |     | Marc H. Hedrick, M.D.                 |
|                         |     | President and Chief Executive Officer |

Pursuant to the requirements of the Securities Act, this registration statement has been signed by the following persons in the capacities held and on the dates indicated.

| Signature                 
 /S/ Marc H. Hedrick       
 MARC H. HEDRICK, M.D.     
 /S/ Andrew Sims           
 ANDREW SIMS               |     | Title                                           
 President, Chief Executive Officer and Director 
 (Principal Executive Officer)                   
 Chief Financial Officer                         
 (Principal Financial and Accounting Officer)    |     | Date           
 April 23, 2025 
 April 23, 2025 |
|:--------------------------|:----|:------------------------------------------------|:----|:---------------|
| *                         
 RICHARD J. HAWKINS        |     | Chair of the Board of Directors                 |     | April 23, 2025 |
| *                         
 HOWARD CLOWES             |     | Director                                        |     | April