Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 407

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 407
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 Dorman Followwill(6)                                            |     |              |     6,970 |     |     |        |     * |   |     |                          |          — |     |           |      — |   |     |       |     * |   |
| Annu Navani, M.D.(7)                                            |     |              |     1,339 |     |     |        |     * |   |     |                          |          — |     |           |      — |   |     |       |     * |   |
| Yue Alexander Wu, Ph.D.(8)                                      |     |              |    16,134 |     |     |        |     * |   |     |                          |          — |     |           |      — |   |     |       |     * |   |
| All Directors and Executive Officers as a Group (7 individuals) |     |              |   588,959 |     |     |        |  7.84 | % |     |                          |          — |     |           |      — |   |     |       |  6.99 | % |
| 5% Beneficial Owners                                            |     |              |           |     |     |        |       |   |     |                          |            |     |           |        |   |     |       |       |   |
| SCLX Stock Acquisition JV LLC                                   |     |              | 1,472,281 |  -9 |     |        | 21.14 | % |     |                          | 29,057,097 |     |           | 100.00 | % |     |       | 30.36 | % |
| Oramed Pharmaceuticals Inc.                                     |     |              |   732,717 | -10 |     |        |  9.99 | % |     |                          |          — |     |           |      — |   |     |       |  8.87 | % |

| * | Less than 1%. |

| (1) | Unless otherwise indicated, the business address of each of the following individuals is 960 San Antonio Road, 
 Palo Alto, CA 94303.                                                                                           |

256

| (2) | Represents 307,909 shares subject to options exercisable within 60 days of March 31, 2025, 3,980 shares                        
 held directly and an aggregate of 4,453 shares held by