Company: SHPH
Filing Date: 2025-03-06
Form Type: CORRESP
Source: 0001493152-25-009317
Chunk: 0

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-03-06
Form: CORRESP
Chunk 0
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<div align='center'>SHUTTLE PHARMACEUTICALS HOLDINGS, INC.

401 Professional Drive, Suite 260

Gaithersburg, MD 20879

(240) 430-4212</div>

March 6, 2025

Via EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

| Re: | Shuttle                        
 Pharmaceuticals Holdings, Inc. |
|     | Registration                   
 Statement on Form S-1          |
|     | File                           
 No. 333-284889                 |

Acceleration Request

| Requested 
 Date:     | Friday,         
 March 7, 2025   |
|:----------|:----------------|
| Requested 
 Time:     | 4:30            
 PM Eastern Time |

Ladies and Gentlemen:

Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Shuttle Pharmaceuticals Holdings, Inc. (the “Registrant”) hereby requests acceleration of the effective date of its registration statement on Form S-1 (File No. 333-284889) so that it may become effective at 4:30 p.m. Eastern Time on Friday, March 7, 2025, or at such time as the Registrant may request by telephone to the staff of the Securities and Exchange Commission. In addition, the Registrant hereby authorizes Megan J. Penick, Esq. of Dorsey & Whitney LLP, counsel for the Registrant, to make such request on the Registrant’s behalf.

| Very                           
 truly yours,                   |                           |
| Shuttle                        
 Pharmaceuticals Holdings, Inc. |                           |
| By:                            | /s/                       
 Anatoly Dritschilo        |
| Name:                          | Anatoly                   
 Dritschilo                |
| Title:                         | Chief                     
 Executive Officer and     |
|                                | Chairman                  
 of the Board of Directors |