Company: PRME
Filing Date: 2025-04-22
Form Type: DEF 14A
Source: 0001628280-25-018704
Chunk: 40

Company: Prime Medicine, Inc.
Filing Date: 2025-04-22
Form: DEF 14A
Chunk 40
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 earn an annual cash bonus determined by our compensation committee for NEOs other than Dr. Gottesdiener, and by our Board on the recommendation of our compensation committee for Dr. Gottesdiener, based on our corporate performance. The target annual bonus for each of our NEOs for the fiscal year ended December 31, 2024 was equal to the percentage of the executive’s respective annual base salary as of December 31, 2024 specified below:

| Name                               |     | Target Bonus Percentage |
| Keith Gottesdiener, M.D.           |     | 60%                     |
| Allan Reine, M.D.                  |     | 40%                     |
| Jeremy Duffield, M.D., Ph.D., FRCP |     | 40%                     |

In 2024, annual bonus for our Chief Executive Officer and other NEOs were based entirely on the level of corporate achievement against our 2024 corporate objectives. With respect to the fiscal year ended December 31, 2024, our compensation committee approved a payout of cash bonuses in an amount of 100% of target for each of the NEOs other than Dr. Gottesdiener, and our Board approved a payout of a cash bonus in an amount of 100% of target for Dr. Gottesdiener.

Milestone Bonus

Pursuant to Dr. Duffield’s employment agreement, upon our achievement of certain performance-based milestones, Dr. Duffield was eligible to earn a $100,000 bonus for each milestone achieved, payable in lump sum, for a total of $300,000. Two of the performance-based milestones were met prior to 2024 and the final performance-based milestone was met in 2024.

Sign-On Bonus

In connection with Dr. Reine’s commencement of employment with us as our Chief Financial Officer, he received a one-time sign-on bonus of $176,000, subject to full repayment if he voluntarily leaves the Company within one year of his start date.

#### Equity-Based Compensation
We believe that long-term equity incentives provide our executives with a strong link to our long-term performance and create an ownership culture. These equity awards are a key aspect of our compensation philosophy and serve to align the interests of our executive officers with our stockholders, as they are tied to future increases in the value of

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our stock. Further, we believe that equity awards with a time-based vesting feature promote retention because this feature incentivizes