Company: RPTX
Filing Date: 2025-12-03
Form Type: PREM14A
Source: 0001193125-25-306948
Chunk: 31

Company: Repare Therapeutics Inc.
Filing Date: 2025-12-03
Form: PREM14A
Chunk 31
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ers (as defined below). Such summary is not
intended to be legal or tax advice to any particular Shareholder. Shareholders should consult their tax advisors with respect to their particular circumstances.

12

Certain Canadian Federal Income Tax Considerations

Shareholders should read carefully the information in the section entitled “Certain Canadian Federal Income Tax Considerations of the Arrangement” of this Circular and Proxy Statement, which sets out a general summary of certain Canadian federal income tax considerations that may be relevant to Resident Holders. Such summary is not intended to be legal or tax advice to
any particular Shareholder. Shareholders should consult their tax advisors with respect to their particular circumstances.

Currency and Exchange Rates

Unless otherwise indicated, all references to “$,” “US$” or “U.S. dollars” are to
United States dollars, references to “CDN$” or “Canadian dollars” are to Canadian dollars. As at November 18, 2025, the exchange rate for one United States dollar expressed in Canadian dollars, as quoted by the Bank of
Canada, was US$1.00=CDN$1.40.

13

QUESTIONS AND ANSWERS ABOUT THE SPECIAL MEETING AND THE ARRANGEMENT The following questions and answers address briefly some questions that Shareholders may have regarding the Special Meeting and the Arrangement. These questions and answers may not address all questions that may be important to you as a Shareholder of the Company. More detailed information will be contained in the balance of this Circular and Proxy Statement.

| Q: | Why am I receiving these materials? |

| A: | The Board is furnishing this Circular and Proxy Statement and form of proxy card to Shareholders in connection 
 with the solicitation of proxies to be voted at the Special Meeting.                                           |

| Q: | When and where is the Special Meeting? |

| Q: | What matters will be voted on at the Special Meeting? |

| A: | You will be asked to vote on the following: |

| • |     | to consider and, if thought advisable, to pass, with or without variation, the Arrangement Resolution, the full 
 text of which is set forth in Annex D, approving the Arrangement;                                               |

| • |     | to consider and, if thought advisable, to pass, with or without variation, the Compensation Resolution; |

| • |     | to consider and, if thought advisable, to pass, with or without variation, (i) the Liquidation Resolution 
 and (ii) Liquid