Company: RVRC
Filing Date: 2025-10-03
Form Type: S-1/A
Source: 0001213900-25-096094
Chunk: 36

Company: Revium Rx.
Filing Date: 2025-10-03
Form: S-1/A
Chunk 36
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 in research and development activities. Our employees,
service providers, directors and officers are residents of Israel.

In October 2023, Hamas terrorists infiltrated
Israel’s border with the Gaza Strip and conducted a series of attacks on civilian and military targets. Following the attack, Israel’s
security cabinet declared war against Hamas and a military campaign commenced in the Gaza Strip. The continuation of the conflict has
led to heightened security concerns, potential disruptions to business operations, and economic instability. There remains significant
uncertainty regarding the duration and escalation of the conflict, and further military actions, restrictions, or government-imposed
measures could adversely affect our operations and financial condition. Other regional hostilities, since October 7, 2023, have concurrently
become more pronounced. This includes and has included a northern front war between Israel and Hezbollah and continued conflict with
the Houthi Movement in Yemen as well as the direct conflict between Israel and Iran which began on June 13 until a ceasefire was declared
on June 25, 2025. Nonetheless, hostilities between Israel and Iran may resume and further escalate, with both sides launching attacks
against one another. Such potential disruption to our operations, if happen in the future again, may include certain delays in our development
efforts.

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The intensity and duration
of the multi-front conflict are difficult to predict, as are such conflict’s economic implications on our business and operations
and on Israel’s economy in general. The potential deterioration of Israel’s economy, as a direct and indirect result of these
events, may have a material adverse effect on the Company and its ability to effectively conduct its operations.

Prior to October 2023,
the Israeli government pursued extensive changes to Israel’s judicial system. In response to the foregoing developments, individuals,
organizations and institutions, both within and outside of Israel, have voiced concerns that the proposed changes may negatively impact
the business environment in Israel including due to reluctance of foreign investors to invest or transact business in Israel as well as
to increased currency fluctuations, downgrades in credit rating, increased interest rates, increased volatility in securities markets,
and other changes in macroeconomic conditions. To the extent that any of these negative developments do occur, they may have an adverse
effect on our business, our results of operations and our ability to raise additional funds, if deemed necessary by our management and
board of directors.

Our operations and the operations of our contractors in Israel may be disrupted as a result of the obligation