Company: SMNR
Filing Date: 2025-08-12
Form Type: S-4/A
Source: 0001193125-25-178821
Chunk: 1064

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-08-12
Form: S-4/A
Chunk 1064
---
 WITNESS WHEREOF, the undersigned have caused this Agreement to be executed as of the date first written above.

| SEMNUR PHARMACEUTICALS, INC.                 |     |                   |
| By:                                          |     |                   |
|                                              |     | Name: Jaisim Shah |
| Title: Chief Executive Officer and President |     |                   |
| EXISTING HOLDERS:                            |     |                   |
| DENALI CAPITAL GLOBAL INVESTMENTS LLC        |     |                   |
| By:                                          |     |                   |
|                                              |     | Name:             |
|                                              |     | Title:            |
| By:                                          |     |                   |
|                                              |     | Huifeng Chang     |
| By:                                          |     |                   |
|                                              |     | Lei Huang         |
| By:                                          |     |                   |
|                                              |     | Jim Mao           |
| By:                                          |     |                   |
|                                              |     | You “Patrick” Sun |
| By:                                          |     |                   |
|                                              |     | Kevin Vassily     |

[Signature Page to Amended and Restated Registration Rights Agreement] F-18

| NEW HOLDER:            |     |                                              |
| SCILEX HOLDING COMPANY |     |                                              |
| By:                    |     |                                              |
|                        |     | Name: Jaisim Shah                            |
|                        |     | Title: Chief Executive Officer and President |

[Signature Page to Amended and Restated Registration Rights Agreement] F-19

**Annex G**

<div align='center'>**CERTIFICATE OF DESIGNATIONS

OF

SEMNUR PHARMACEUTICALS, INC.

a Delaware corporation

(Pursuant to Section151 of the

General Corporation Law of the State of Delaware)**</div>

Semnur Pharmaceuticals, Inc., a Delaware corporation (the “Corporation”), does hereby certify that pursuant to the authority conferred upon the Corporation’s board of directors (together with any duly authorized committee thereof, the “Board of Directors”) by the provisions of the Corporation’s Amended and Restated Certificate of Incorporation, as amended, which authorizes the issuance of up to 45,000,000 shares of preferred stock, par value $0.0001 per share (the “Preferred Stock”), the following resolutions were duly adopted by the Board of Directors on , 2024:

RESOLVED, that the issuance of shares of Preferred Stock is hereby authorized and the