Company: HRTX
Filing Date: 2025-09-19
Form Type: DEF 14A
Source: 0001193125-25-209064
Chunk: 2

Company: HERON THERAPEUTICS, INC. /DE/
Filing Date: 2025-09-19
Form: DEF 14A
Chunk 2
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 following the instructions on the proxy card or the voting instruction card you received, as applicable. In addition, you can also vote by mail by following the instructions on the proxy card or the voting instruction card.

Submitting a proxy or voting instruction card will not prevent you from attending the Special Meeting and voting electronically, if you so desire. Please note, however, that if your shares are held of record by a broker, bank or other agent and you wish to vote at the Special Meeting, you may also submit voting instructions to your broker, bank or other nominee. In most instances, you will be able to do this over the Internet, by telephone or by mail. Please refer to information from your bank, broker, or other nominee on how to submit voting instructions.

<div align='center'>3

100 Regency Forest Drive, Suite 300

Cary, NC 27518

(858) 251-4400

SPECIAL MEETING OF STOCKHOLDERS QUESTIONS AND ANSWERS</div>

The enclosed proxy is being solicited on behalf of our Board of Directors (“Board”) for use at the Special Meeting. The proxy materials, including the Annual Report on Form 10-K for the year ended December 31, 2024, will be made available online athttp://www.proxyvote.comand mailed to stockholders on or about September 19, 2025. We encourage stockholders to vote well before the Special Meeting, even if they plan to attend the Special Meeting (as specified below and in the proxy card you received) or by using the toll-free telephone number provided below or in the proxy card, as applicable. In addition, if you received copies of the proxy materials by mail, you can vote by mail by following the instructions on the proxy card. Stockholders who hold our shares in “street name” should refer to the voting instructions form provided by their broker, bank or other agent for details on how to provide voting instructions to each person. For additional details, see “How can I vote at the Special Meeting?” below.

Only stockholders of record at the close of business on the Record Date will be entitled to vote at the Special Meeting. At the close of business on the Record Date, there were 183,314,409 shares of the Company’s Common Stock outstanding and entitled to vote.

Stockholder of Record: Shares Registered in Your Name

If at the close of business on the Record Date, your shares were registered directly in your name, then you are a stockholder of record.