Company: SFNC
Filing Date: 2025-09-10
Form Type: 424B5
Source: 0001193125-25-200113
Chunk: 16

Company: SIMMONS FIRST NATIONAL CORP
Filing Date: 2025-09-10
Form: 424B5
Chunk 16
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 for general corporate purposes; however, we may determine not to redeem the 2028 Notes or to redeem only a
portion of the 2028 Notes.

Since the Notes will not be secured by any of our assets, the Notes will be effectively subordinated to all of
our secured indebtedness to the extent of the value of the assets securing such indebtedness. The Indenture governing the Notes does not limit the amount of senior indebtedness and other financial obligations or secured obligations that we or our
subsidiaries may incur. Accordingly, we may incur substantial additional indebtedness, including additional indebtedness ranking senior to or on a parity basis with the Notes in the future.

As a result of the subordination provisions described above, holders of the Notes may not be fully repaid in the event of our bankruptcy,
liquidation or reorganization.

The Notes will not be insured or guaranteed by the FDIC, any other governmental agency or any of our subsidiaries. The Notes will be structurally subordinated to the indebtedness and other liabilities of our subsidiaries, which means that creditors of our subsidiaries generally will be paid from those subsidiaries’ assets before holders of the Notes would have any claims to those assets.

The Notes are not bank deposits and are not insured or guaranteed by the
FDIC or any other governmental agency. The Notes will be obligations of Simmons First National Corporation only and will not be obligations of, or guaranteed by, any of our subsidiaries, including Simmons Bank. The Notes will be structurally
subordinated to all existing and future indebtedness and other liabilities of our subsidiaries, which means that creditors of our

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subsidiaries (including, in the case of Simmons Bank, its depositors) generally will be paid from those subsidiaries’ assets before holders of the Notes would have any claims to those
assets. Even if we become a creditor of any of our subsidiaries, our rights as a creditor would be subordinate to any security interest in the assets of that subsidiary and any debt of that subsidiary senior to that held by us, and our rights could
otherwise be subordinated to the rights of other creditors and depositors of that subsidiary. Furthermore, none of our subsidiaries is under any obligation to make payments to us, and any payments to us would depend on the earnings or financial
condition of our subsidiaries and various business considerations. Statutory, contractual or other restrictions also limit our subsidiaries’ ability to pay dividends or make distributions, loans or advances to us. For these reasons, we may not
have access to any assets