Company: TAK
Filing Date: 2025-06-26
Form Type: 424B5
Source: 0001395064-25-000101
Chunk: 15

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-26
Form: 424B5
Chunk 15
---
 of March 31, 2025, TPC’s short-term drawings outstanding under its short-term commercial paper facility totaled approximately ¥270.0 billion, and were subject to a weighted average interest rate of approximately 0.57%. TPC intends to reduce such drawings using the net proceeds both from the offering of the Notes and from the offering of an aggregate principal amount of ¥184.0 billion Japanese yen-denominated senior notes issued on June 12, 2025. The $500.0 million short-term loan is currently being rolled over on a monthly basis and is subject to a floating interest rate (one-month SOFR plus a fixed spread). TPC will use any remaining proceeds for paying down other indebtedness and general corporate purposes.

<div align='center'>S-10</div>

### CAPITALIZATION AND INDEBTEDNESS
The following table sets forth Takeda’s consolidated capitalization and indebtedness as of March 31, 2025 presented in accordance with IFRS, on an actual basis and on an as adjusted basis to give effect to the offering and sale of the Notes, but not the use of proceeds therefrom. You should read this table in conjunction with the consolidated financial statements and related notes incorporated by reference in this prospectus supplement.

|                                              |     | As of March 31, 2025 |         |     |             |         |
|:---------------------------------------------|:----|:---------------------|--------:|:----|:------------|--------:|
|                                              |     | Actual               |         |     | As Adjusted |         |
|                                              |     | -billions of yen     |         |     |             |         |
| Short-term Debt:                             |     |                      |         |     |             |         |
| Current portion of bonds and loans           |     | ¥    548.9           |         |     | ¥    548.9  |         |
| Long-term Debt:                              |     |                      |         |     |             |         |
| Non-current portion of bonds and loans(1)    |     |                      | 3,966.3 |     |             | 3,966.3 |
| Notes being offered hereby(2)                |     |                      |       — |     |             |         |
| Equity:                                      |     |                      |         |     |             |         |
| Share capital                                
 Authorized—3,500,000,000 shares;             
 Issued—1,590,