Company: PFSA
Filing Date: 2025-05-15
Form Type: 424B3
Source: 0001213900-25-044417
Chunk: 296

Company: Profusa, Inc.
Filing Date: 2025-05-15
Form: 424B3
Chunk 296
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 prove to be incorrect. For example, if the annual total addressable markets or the potential market growth for Profusa’s Lumee Oxygen product is smaller than Profusa has estimated or if the key business metrics Profusa utilized to forecast commercial opportunities are inaccurate, it may have an adverse effect on Profusa’s business, financial condition, results of operations and prospects. ____________ 10https://journals.viamedica.pl/clinical_diabetology/article/view/61700 11https://www.health.com/condition/type -2-diabetes/12 - myths-about - insulin-and -type-2-diabetes 12https://accisstoolkit.haiweb.org/wp -content/uploads/2020/10/Estimate -of - Insulin-Use - in-Type -2-Diabetes1.pdf 13https://www.liebertpub.com/doi/epdf/10.1089/dia.2021.0271 14https://www.census.gov/topics/population.html — This source shows the massive health and wellness market which does not require reimbursement 15https://ec.europa.eu/urostat/web/population -demography/population -housing -censuses/database — only population 18 and over was considered 16https://www.cdc.gov/diabetes/basics/prediabetes.html#:~:text=What%20Is%20Prediabetes%3F,t%20know%20they
%20have%20it. 17https://www.cdc.gov/diabetes/basics/prediabetes.html#:~:text=What%20Is%20Prediabetes%3F,t%20know%20they
%20have%20it. 148

Basis of revenue assumptions Development of the revenue estimates for Lumee Oxygen and Lumee Glucose relied on calculations of the total addressable market available to potential penetration by both products. In the case of Lumee Glucose, revenue includes both sales of Lumee Glucose in its personal use and professional -useapplications. Profusa calculated the total addressable market by defining relevant active market segments in both the United States and European Union for both Lumee Oxygen and Lumee Glucose. Market segments for Lumee Glucose included Type 1 and Type 2 diabetics, Type 2 diabetics not on insulin, prediabetic, and the emerging health and wellness segment. The market segments used for Lumee Oxygen were the critical limb ischemia (CLI)