Company: HCWB
Filing Date: 2025-04-16
Form Type: 424B3
Source: 0001193125-25-082835
Chunk: 100

Company: HCW Biologics Inc.
Filing Date: 2025-04-16
Form: 424B3
Chunk 100
---
 sale and (ii) HCWB is subject to the Exchange Act periodic reporting requirements for at least three months before the sale
and has filed all required reports under Section 13 or 15(d) of the Exchange Act during the 12 months (or such shorter period as it was required to file reports) preceding the sale.

Persons who have beneficially owned restricted shares of Common Stock of HCWB for at least six months but who are affiliates of HCWB at
the time of, or at any time during the three months preceding, a sale would be subject to additional restrictions, by which such person would be entitled to sell within any three-month period only a number of securities that does not exceed the
average weekly reported trading volume of Common Stock during the four calendar weeks preceding the filing of a notice on Form 144 with respect to the sale.

Sales by affiliates of HCWB under Rule 144 are also limited by manner of sale provisions and notice requirements and by the availability
of current public information about HCWB.

67

PLAN OF DISTRIBUTION The shares of Common Stock listed in the table appearing under “Selling Stockholders” are being registered to permit the resale of Common Stock by the selling stockholders from time to time after the date of this prospectus. There can be no assurance that the selling stockholders will sell any or all of the Common Stock offered hereby. We will not receive any of the proceeds from the sale of the Common Stock by the selling stockholder. The selling stockholders may sell all or a portion of the Common Stock offered hereby from time to time directly to purchasers or through one or more underwriters, broker-dealers or agents, at either market prices prevailing at the time of sale or at privately negotiated prices (but not at a fixed price), by a variety of methods including the following:

| • |     | on any national securities exchange or                                                         
 over-the-counter market on which the Common Stock may be listed or quoted at the time of sale; |

| • |     | ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers; |

| • |     | block trades in which a broker-dealer may attempt to sell the shares as agent but may position and resell a 
 portion of the block as principal to facilitate the transaction;                                            |

| • |     | purchases by a broker-dealer, as principal, and a subsequent resale by the broker-dealer for its account; |

| • |     | an exchange distribution in accordance with the rules of the applicable exchange; |