Company: MIRM
Filing Date: 2025-08-12
Form Type: S-3ASR
Source: 0001193125-25-178937
Chunk: 34

Company: Mirum Pharmaceuticals, Inc.
Filing Date: 2025-08-12
Form: S-3ASR
Chunk 34
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 cannot cause the securities to be registered in his or her name, and cannot obtain non-global certificates for his or her interest in the securities, except in the special situations we describe below; |

| • |     | an investor will be an indirect holder and must look to his or her own bank or broker for payments on the 
 securities and protection of his or her legal rights relating to the securities, as we describe above;    |

| • |     | an investor may not be able to sell interests in the securities to some insurance companies and to other 
 institutions that are required by law to own their securities in non-book-entry form;                    |

| • |     | an investor may not be able to pledge his or her interest in the global security in circumstances where                                              
 certificates representing the securities must be delivered to the lender or other beneficiary of the pledge in order for the pledge to be effective; |

| • |     | the depositary’s policies, which may change from time to time, will govern payments, transfers, exchanges 
 and other matters relating to an investor’s interest in the global security;                              |

| • |     | we and any applicable trustee have no responsibility for any aspect of the depositary’s actions or for its                        
 records of ownership interests in the global security, nor will we or any applicable trustee supervise the depositary in any way; |

| • |     | the depositary may, and we understand that DTC will, require that those who purchase and sell interests in the                              
 global security within its book-entry system use immediately available funds, and your broker or bank may require you to do so as well; and |

| • |     | financial institutions that participate in the depositary’s book-entry system, and through which an investor                                          
 holds its interest in the global security, may also have their own policies affecting payments, notices and other matters relating to the securities. |

There may be more than one financial intermediary in the chain of ownership for an investor. We do not monitor and are not responsible for the actions of any of those intermediaries. Special Situations When a Global Security Will Be Terminated In a few special situations described below, a global security will terminate and interests in it will be exchanged for physical certificates representing those interests. After that exchange, the choice of whether to hold securities directly or in street name will be up to the investor. Investors must consult their own banks or brokers to find out how to have their interests in securities transferred to their own names, so that they will be direct holders