Company: SHPH
Filing Date: 2025-04-21
Form Type: DEFR14A
Source: 0001641172-25-005474
Chunk: 41

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-04-21
Form: DEFR14A
Chunk 41
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wards may be made to service providers (employees, directors and consultants) of the Company or any affiliate of the Company.
Incentive stock options may only be granted to employees.

Options.The 2018 Plan permits granting of options to purchase shares intended to qualify as incentive stock options or non-qualified
stock options. The exercise price must be at least 100% of fair market value on the grant date (110% for certain 10% stockholders receiving
ISOs). The term may not exceed 10 years (5 years for certain 10% stockholders receiving ISOs).

Other Awards. The administrator may also award stock appreciation rights, which are rights to receive payment based on the increase
in fair market value; restricted stock, which refers to shares subject to restrictions and risk of forfeiture; restricted stock units,
which are bookkeeping entries representing share value; and performance units/shares, which are awards that may be earned upon achievement
of performance objectives.

Effect of Certain Corporate Transactions. In the event of a change in control, outstanding awards may be assumed, substituted, or
accelerated, as determined by the administrator. Change in control includes 50% ownership changes, Board of Directors’ composition
changes, and substantial asset sales.

Transferability.Awards generally may not be sold, transferred, pledged, or assigned other than by will or laws of descent and distribution,
unless the administrator determines otherwise.

Adjustments.The administrator will make appropriate adjustments to outstanding awards in the event of stock splits, dividends, or similar
corporate events.

Amendment or Termination of the 2018 Plan. The administrator may amend, alter, suspend or terminate the 2018 Plan at any time. The 2018
Plan terminates 10 years from its effective date.

New Plan Benefits

Because future awards of stock options, restricted
stock or other equity awards under the 2018 Plan will be made at the discretion of the Compensation Committee, no data can be provided
regarding the benefits or amounts that will be received by any participant or groups of participants if the First Amendment is approved.

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Outstanding Equity Awards at Fiscal Year-End

As of December 31, 2024, a total of 1,109,741 RSUs have been granted to our executive officers and directors under our 2018 Equity Incentive Plan (the “Plan”), of which 29,263 RSUs had vested and 1,079,645 remain subject to vesting. The Company has filed a registration