Company: NCNA
Filing Date: 2025-04-24
Form Type: F-6
Source: 0001193805-25-000556
Chunk: 1

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-6
Chunk 1
---
* |           Proposed Maximum 
 Aggregate Offering Price** |        Amount of 
 Registration Fee |
| American Depositary Shares (the “ADS(s))”, each ADS representing the right to receive twenty-five (25) ordinary shares of NuCana plc (the “Company”)                                                                                                                                                                                                                                                                                                                                                                                              | 2,000,000,000 ADSs |                     $5.00 |               $100,000,000 |       $15,310.00 |
| *     Each                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
 unit represents 100 ADSs.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
 **   Estimated                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 solely for the purpose of calculating the registration fee. Pursuant to Rule 457(k), such estimate is computed on the basis of the maximum                                                                                                                                                                                                                                                                                                                                                                                                        
 aggregate fees or charges to be imposed in connection with the issuance of ADSs.                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |                    |                           |                            |                  |
| The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until this Registration Statement shall become effective on such date as the United States Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine. |                    |                           |                            |                  |

This Registration Statement may be executed
in any number of counterparts, each of which shall be deemed an original, and all of such counterparts together shall constitute one and
the same instrument.

<div align='center'>ii

PART I

INFORMATION REQUIRED IN PROSPECTUS

Cross Reference Sheet</div>

| Item 1. | DESCRIPTION                    
 OF SECURITIES TO BE REGISTERED |

| Item               
 Number and Caption |                                                                  |                                                                                                               |     | Location in Form of American                                                 
 Depositary Receipt (“Receipt”)                                               
 Filed Herewith as Prospectus                                                 |
| 1.                 | Name of Depositary and address of its principal executive office |                                                                                                               |     | Face of Receipt - Introductory Article.                                      |
| 2.                 | Title of Receipts and identity of deposited securities           |                                                                                                               |     | Face of Receipt - Top Center.                                                |
|                    | Terms of Deposit:                                                |                                                                                                               |     |                                                                              |
|                    | -i                                                               | The amount of deposited securities represented by one American Depositary Share ("ADSs")                      |     | Face