Company: GHRS
Filing Date: 2025-07-29
Form Type: 20-F/A
Source: 0001140361-25-027850
Chunk: 132

Company: GH Research PLC
Filing Date: 2025-07-29
Form: 20-F/A
Chunk 132
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 or relocation of our operations, retain key employees, or identify, recruit and train additional qualified personnel. Our inability to manage the expansion or relocation of our operations effectively may result in weaknesses in our infrastructure, give rise to operational mistakes, loss of business opportunities, loss of employees and reduced productivity among remaining employees. Our expected growth could also require significant capital expenditures and may divert financial resources from other projects, such as the development of existing and additional product candidates. If we are unable to effectively manage our expected growth, our expenses may increase more than expected, our ability to generate revenues could be reduced and we may not be able to implement our business strategy, including the successful commercialization of our product candidates. Our business is subject to economic, political, regulatory and other risks associated with international operations. Our business is subject to risks associated with conducting business internationally. Accordingly, our future results could be harmed by a variety of factors, including:

| • | economic weakness, including inflation, or political instability in particular in foreign economies and markets; |

| • | differing and changing regulatory requirements, price controls and reimbursement regimes; |

| • | potentially reduced protection for our intellectual property rights; |

| • | difficulties in compliance with different, complex and changing laws, regulations and court systems of multiple jurisdictions and compliance with a wide variety of foreign laws, treaties and regulations; |

| • | changes in regulations and customs, tariffs and trade barriers; |

| • | changes in currency exchange rates and currency controls; |

| • | changes in a specific country’s or region’s political or economic environment; |

| • | trade protection measures, import or export licensing requirements or other restrictive actions by governments; |

| • | negative consequences from changes in, including the interpretation of, tax laws; |

| • | compliance with tax, employment, immigration and labor laws for employees living or traveling abroad; |

| • | workforce uncertainty in countries where labor unrest is more common than in the United States and the EEA; |

| • | difficulties associated with staffing and managing international operations, including differing labor relations; |

| • | business interruptions resulting from geo-political actions, including war and terrorism, natural disasters including earthquakes, typhoons, floods and fires, or pandemics, epidemics, outbreaks of an infectious disease or similar 
 events; and                                                                                                                                                                                                                           |

| • | cyber-attacks, which are growing in frequency, sophistication and intensity, and are becoming increasingly difficult to detect. |

71 Table of Contents If a pandemic, epidemic, outbreak of an infectious disease or