Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 186

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 186
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   |           |                    |  12,209 | -12 |   |     |    * |   |     |                             |    12,209 | -13 |           |                    |       — |     |   |     |    — |   |

| * | Less than 1% |

| (1) | Beneficial ownership is determined in accordance with Rule 13d-3 under                                                                                                                                                                            
 the Exchange Act. In computing the number of shares beneficially owned by a person and the percentage ownership of that person, shares of Common Stock subject to warrants, options and other convertible securities held by that person that are 
 currently exercisable or exercisable within 60 days of December 5, 2025 are deemed outstanding. Shares of Common Stock subject to warrants, options and other convertible securities, however, are not deemed outstanding for the purpose of      
 computing the percentage ownership of any other person.                                                                                                                                                                                           |

| (2) | Represents 517,425 shares of Common Stock held directly and excludes an aggregate of 1,832,418 shares                                                                                       
 of Common Stock underlying certain warrants to purchase Common Stock held by the Selling Stockholder, comprised of: (i) 475,824 shares underlying the December 2024 RDO Common Warrants and |

116

| (ii) 1,356,594 shares underlying the November 2025 Investor Warrants which are subject to a 4.99% beneficial ownership limitation. The securities are directly held by Armistice Capital                                
 Master Fund Ltd., a Cayman Islands exempted company (the “Master Fund”), and may be deemed to be beneficially owned by: (i) Armistice Capital, LLC (“Armistice Capital”), as the investment manager of the Master Fund; 
 and (ii) Steven Boyd, as the Managing Member of Armistice Capital. The address of Armistice Capital Master Fund Ltd. is c/o Armistice Capital, LLC, 510 Madison Avenue, 7th Floor, New York, NY 10022.                  |

| (3) | Comprised of 1,356,594 shares of Common Stock being registered for resale under this Prospectus issuable upon                                                                                                                                           
 the exercise of the November 2025 Investor Warrant issued to the Selling Stockholder. The warrants are subject to a beneficial ownership limitation of 4.99%, which restricts the Selling Stockholder from exercising that portion of the warrants that 
 would result in the Selling Stockholder and its affiliates owning,