Company: NCNA
Filing Date: 2025-06-27
Form Type: 424B5
Source: 0001193125-25-151464
Chunk: 15

Company: NuCana plc
Filing Date: 2025-06-27
Form: 424B5
Chunk 15
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2025, under a registered direct offering, of 61,323,375 ordinary shares, and Pre-FundedWarrants to purchase up to 209,826,250 ordinary shares in lieu of ADSs, which were subsequently exercised in full, and accompanying Series A Warrants and Series B Warrants, as well as the subsequent issuance of 9,117,817,625 ordinary shares pursuant to the exercise of Series A Warrants and the exercise of all Series B Warrants, resulting in net proceeds, after deducting placement agent fees and estimates of other related expenses, of £8.0 million, our proforma net tangible book value at March 31, 2025 would have been £10.0 million, or £0.00 per ordinary share, equivalent to $0.00 per ordinary share and $0.03 per ADS. No adjustments have been made to the pro forma net tangible book value to reflect the fair value of Pre-FundedWarrants, the Series A Warrants or the Series B Warrants as at issuance or as at exercise, as required under IFRS. After giving effect to the sale of our ADSs in the aggregate amount of $100.0 million at an assumed offering price of $0.10 per ADS, the reported sale price of our ADSs on The Nasdaq Capital Market on June 20, 2025, and after deducting commissions and estimated offering expenses payable by us, our as adjusted net tangible book value as of March 31, 2025 would have been £84.8 million, or £0.00 per ordinary share, equivalent to $0.00 per ordinary share and $0.08 per ADS. This represents an immediate increase in net tangible book value of $0.00 per ordinary share and $0.05 per ADS to our existing shareholders and an immediate dilution in net tangible book value of $0.00 per ordinary share and $0.02 per ADS to new investors in this offering. The following table illustrates this calculation on a per ADS basis. The as adjusted information is illustrative only and will adjust based on the actual price to the public, the actual number of ADSs sold and other terms of the offering determined at the time our ADSs are sold pursuant to this prospectus supplement. The ADSs sold in this offering, if any, will be sold from time to time at various prices.

| Assumed public offering price per ADS                                           |     |    |      |   |     | $ | 0