Company: TVRD
Filing Date: 2025-11-13
Form Type: 424B3
Source: 0001104659-25-111336
Chunk: 195

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-11-13
Form: 424B3
Chunk 195
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 gather, collect, or infer sensitive information about us from public sources, data
brokers, or other means that reveal competitively sensitive details about our organization and could be used to undermine our competitive
advantage or market position.

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Any of the previously identified or similar threats
have in the past and may in the future cause a security incident or other interruption that have in the past and may in the future result
in unauthorized, unlawful, or accidental acquisition, modification, destruction, loss, alteration, encryption, disclosure of, or access
to our sensitive information or our information technology systems, or those of the third parties with whom we work. For example, we have
been the target of unsuccessful phishing attempts in the past and expect such attempts will continue in the future. A security incident
or other interruption could disrupt our ability (and that of third parties with whom we work) to operate our business.

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Our contracts may not contain limitations of liability,
and even where they do, there can be no assurance that limitations of liability in our contracts are sufficient to protect us from liabilities,
damages, or claims related to our data privacy and security obligations. In addition, while Tvardi maintains insurance policies that may
cover certain liabilities in connection with a cybersecurity incident, it cannot be certain that the insurance coverage will be adequate
for liabilities actually incurred, that insurance will continue to be available to Tvardi on commercially reasonable terms, or at all,
or that any insurer will not deny coverage as to any future claim. The successful assertion of one or more large claims that exceed available
insurance coverage, or the occurrence of changes in insurance policies, including premium increases or the imposition of large deductible
or co-insurance requirements, could have a material adverse effect on its business, including its financial condition, results of operations
and reputation.

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Unfavorable global economic conditions could adversely affect Tvardi’s business, financial condition or results of operations.

Tvardi’s results of operations could be adversely
affected by general conditions in the global economy and in the global financial markets. Portions of Tvardi’s future clinical trials
may be conducted outside of the United States and unfavorable economic conditions resulting in the weakening of the U.S. dollar would
make those clinical trials costlier to operate. Furthermore, the most recent global financial crisis caused extreme volatility and disruptions
in the capital and credit markets. A severe or prolonged economic downturn, due to factors including the effects of health epidemics and
pandemics, geopolitical events, such as the