Company: TEM
Filing Date: 2025-08-08
Form Type: S-3ASR
Source: 0001193125-25-175993
Chunk: 72

Company: Tempus AI, Inc.
Filing Date: 2025-08-08
Form: S-3ASR
Chunk 72
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| • |     | 11,803,575 shares of Class A common stock reserved for issuance upon the conversion of our 0.75% convertible 
 senior notes due 2030 as of June 30, 2025; and                                                               |

| • |     | shares of Class A common stock issuable upon conversion of the convertible promissory note we issued to Google                                                                                                                                         
 LLC, which note was most recently amended in February 2025, and is convertible beginning in December 2030 into a number of shares of Class A common stock equal to the quotient obtained by dividing (1) the then outstanding principal amount of such 
 note (which was $238.3 million as of the time of the latest amendment), by (2) the average of the last trading price on each trading day during the twenty-day period ending immediately prior to December 31, 2030.                                   |

4

RISK FACTORS

Investing in our Class A common stock involves a high degree of risk. Before deciding whether to invest in our Class A common stock, you should consider carefully the risks and uncertainties described below together with all of the other information contained in this prospectus and in the section titled “Risk Factors” contained in any applicable prospectus supplement and any related free writing prospectus, and described under the section titled “Risk Factors” contained in our most recent Annual Report on Form 10-Kand subsequent Quarterly Reports on Form 10-Q,as well as any amendments thereto reflected in subsequent filings with the SEC, which are incorporated by reference into this prospectus in their entirety, together with other information in this prospectus, the documents incorporated by reference in this prospectus, any applicable prospectus supplement and any free writing prospectus that we may authorize for use in connection with a specific offering. See the sections titled “Where You Can Find More Information” and “Incorporation of Certain Information by Reference.” The risks described in these documents are not the only ones we face, but those that we consider to be material. There may be other unknown or unpredictable economic, business, competitive, regulatory or other factors that could have material adverse effects on our business, financial condition, results of operations and prospects. Past financial performance may not be a reliable indicator of future performance, and historical trends should not be used to anticipate results or trends in future periods. If any of these risks actually occurs, our business, financial condition, results of operations or cash flow could be seriously harmed. This could cause the trading price of our