Company: SHPH
Filing Date: 2025-04-21
Form Type: DEFR14A
Source: 0001641172-25-005474
Chunk: 49

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-04-21
Form: DEFR14A
Chunk 49
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Yes. You can revoke your proxy vote at any time before it is exercised at the Annual Meeting in any of these three ways:

| ● | by                                                                                                                                
 submitting written notice revoking your proxy card to the Secretary of the Company;                                               |
| ● | by                                                                                                                                
 submitting another proxy via the Internet or by mail that is dated after your original proxy vote and, if by mail, it is properly 
 signed; or                                                                                                                        |
| ● | by                                                                                                                                
 attending the Annual Meeting and voting at that time.                                                                             |

| 33 |

Beneficial Owners (shares registered in the name of your broker, bank or other nominee):

If your shares of Shuttle Pharmaceuticals common stock are held by a broker, bank, or other nominee (in “street name”), you will receive instructions from them on how to vote your shares. If your shares are held by a broker and you do not give the broker specific instructions on how to vote your shares, your broker may vote your shares at its discretion on “routine” matters to be acted upon at the Annual Meeting. However, your shares will not be voted on any “non-routine” matters. An absence of voting instructions on any “non-routine” matters will result in a “broker non-vote.”

The only “routine” matter to be acted upon at the Annual Meeting is:

The Company expects that the Reverse Stock Split proposal will be treated as a non-routine matter, which means that your broker or other nominee will not have discretionary authority to vote your shares held in street name on this matter. Accordingly, in the absence of your voting instructions, your broker or nominee may not vote your shares on Proposal 4. Accordingly, all other matters to be acted upon at the Annual Meeting are “non-routine” matters. As such, if you hold all or any portion of your shares in street name and you do not give your broker or bank specific instructions on how to vote your shares, your shares will not be voted on the following “non-routine” matters:

| ● | Proposal                                                                                                                           
 1: Election of the five directors named in this proxy statement.                                                                   |
| ● | Proposal                                                                                                                           
 3: Approval (on an advisory basis) of the Company’s executive compensation.                                                        |
| ● | Proposal                                                                                                                           
 4: Authorization of the Board of Directors to amend the Company’s amended and restated certificate of incorporation to effect      
 a Reverse Stock Split of all of the Company’s issued and outstanding common stock by a ratio in the range of