Company: MDCXW
Filing Date: 2025-09-11
Form Type: DRS
Source: 0001062993-25-015568
Chunk: 127

Company: Medicus Pharma Ltd.
Filing Date: 2025-09-11
Form: DRS
Chunk 127
---
okinetic data during the Yucatan minipig local tolerance study (Study No. S15055). A total of 30 minipigs (15 males and 15 females) were randomized into five treatment groups. Groups of 3 males and 3 females were treated with a blank control array (Group 1), and three dose levels of D-MNA at 25, 50 and 200 µg/dose of doxorubicin hydrochloride (Groups 2 - 4), respectively. An intravenous ("IV") doxorubicin group consisting of 3 males and 3 females served as a reference control (Group 5). Dosing occurred on Days 1, 7 and 14 with either control array or test article (Groups 1-4), and Group 5 was dosed IV on these same study days. Each topical treatment was 30 minutes. The experimental design is provided in the table below.

Study Design of Minipig Local Tolerance Study

| Group |     | Treatment         |     | Treatment/Dose |     |                                      |     | Number of Animals |     |   |     | Dose Route/       
 Frequency         |
| Array |     | Dosage (µg/dose)  |     |           Male |     |                               Female |     |                   |     |   |     |                   |
| 1     |     | Blank Control     |     |              1 |     |                                    0 |     |                 3 |     | 3 |     | MNA/Days 1, 7, 14 |
| 2     |     | D-MNA-low         |     |              1 |     |                                   25 |     |                 3 |     | 3 |     |                   |
| 3     |     | D-MNA-mid         |     |              1 |     |                                   50 |     |                 3 |     | 3 |     |                   |
| 4     |     | D-MNA-high        |     |              1 |     |                                  200 |     |                 3 |     | 3 |     |                   |
| 5     |     | Reference Control |     |             NA |     | 2 mg/kg (Doxorubicin Hydrocholoride) |     |                 3 |     | 3 |     | IV/Days, 1, 7, 14 |

Note:

(