Company: SMNR
Filing Date: 2025-08-13
Form Type: 424B3
Source: 0001193125-25-179226
Chunk: 939

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-08-13
Form: 424B3
Chunk 939
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 or “the date hereof”, wherever used in the Merger Agreement, as amended by this Amendment,
shall mean August 30, 2024.

4. . This Amendment shall be governed by all provisions of the Merger Agreement
unless context requires otherwise, including all provisions concerning construction, enforcement and governing law.

5. . This Amendment together with the Merger Agreement sets forth the entire agreement of the parties with respect to the subject matter hereof and thereof and supersedes all prior and contemporaneous understandings and agreements related
thereto (whether written or oral), all of which are merged herein. In the event of a conflict between the terms of the Merger Agreement and this Amendment, the terms of this Amendment shall prevail solely as to the subject matter contained herein.

6. . This Amendment may be executed in counterparts, each of which shall constitute an original, but all of which
shall constitute one agreement. This Amendment shall become effective upon delivery to each party of an executed counterpart or the earlier delivery to each party of original, photocopied, or electronically transmitted signature pages that together
(but need not individually) bear the signatures of all other parties.

[The remainder of this page is intentionally left blank; signature pages to follow]

A-3-2

IN WITNESS WHEREOF the parties hereto have caused this Amendment to be duly executed as of the day and year first written above.

| DENALI CAPITAL ACQUISITION CORP. |     |                                 |
| By:                              |     | /s/ Lei Huang                   |
|                                  |     | Name: Lei Huang                 |
|                                  |     | Title:  Chief Executive Officer |
| DENALI MERGER SUB INC.           |     |                                 |
| By:                              |     | /s/ Peter Xu                    |
|                                  |     | Name: Peter Xu                  |
|                                  |     | Title:  President               |
| SEMNUR PHARMACEUTICALS, INC.     |     |                                 |
| By:                              |     | /s/ Jaisim Shah                 |
|                                  |     | Name: Jaisim Shah               |
|                                  |     | Title:  Chief Executive Officer |

Annex B

CERTIFICATE OF INCORPORATION

OF

DENALI CAPITAL ACQUISITION CORP.

a Delaware corporation

ARTICLE I.

NAME

The name of the Corporation is Denali Capital Acquisition Corp.

ARTICLE II.

REGISTERED OFFICE