Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063899
Chunk: 146

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 146
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collect these samples for research purposes. In the past, DiamiR has been able to access these samples and relevant clinical outcomes
(when available) through research collaborations/agreements. Some of these samples have been stored in -80c freezers and will be available
to DiamiR when its clinical validation work begins. One of the key drivers of risk for any clinical study is access to samples.

DiamiR’s studies focused
on research, development and validation of its future products rely on access to single samples from multiple donors as well as multiple
samples from the same donor over a period of time. Furthermore, DiamiR seeks access not only to archived samples but also to samples collected
in prospective studies, which take a long time. Negotiating access to archived and prospectively collected donor samples and clinical
data is typically a lengthy process involving several parties and approvals necessary to resolve complex issues such as research objectives
and parameters, institutional review board approval, donor consent and privacy rights, publication rights, and intellectual property ownership.
If DiamiR is not able to acquire or negotiate access to archived and prospectively collected donor plasma samples and related clinical
data with source organizations, or if its competitors secure access to these samples before DiamiR, its ability to conduct studies to
develop, validate and commercialize future tests will be limited or delayed. However, DiamiR believes that having frozen samples in its
freezers reduces the risk of prolonged study timelines and allows DiamiR to more accurately estimate the number of samples in its study
and to power the study accordingly.

DiamiR relies on a sole supplier for some of the materials used in its tests and services, and it may not be able to find replacements or transition to alternative suppliers in a timely manner.

DiamiR relies on different
sole suppliers for certain materials, kits and supplies that it uses to perform its tests and services for its diagnostic tests. For example,
DiamiR relies on Qiagen GmbH for its qPCR reagents and plates. DiamiR does not maintain an agreement with Qiagen GmbH; their reagents
are readily available for purchase, additionally, the volume of DiamiR’s business is not material to them. In addition to Qiagen,
DiamiR works with other multinational stable corporations for its supplies. Although DiamiR does not currently have any agreements with
other suppliers and technologies, it believes other providers, such as ThermoFisher, which offers the TaqMan qPCR kits are easily accessible
and