Company: TAK
Filing Date: 2025-06-26
Form Type: 424B5
Source: 0001395064-25-000101
Chunk: 10

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-26
Form: 424B5
Chunk 10
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 protection in the event of a change in control;

◦ The risk that the ratings of the Notes could be lowered; and

◦ Potential limited liquidity in the market for the Notes.

For a discussion of these and other risks you should consider before making an investment in the Notes, see “Item 3. Key Information—D. Risk Factors” of Takeda’s most recent annual report on Form 20-F and in the “Risk Factors” section of this prospectus supplement.

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THE OFFERING

| Issuer                                          |     | Takeda U.S. Financing, Inc.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |
| Notes offered                                   |     | $          aggregate principal amount of senior notes due 2035.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
 $           aggregate principal amount of senior notes due 2055.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
 Each series of the Notes will be issued only in fully registered form, without coupons.                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |
| Guarantor                                       |     | Takeda Pharmaceutical Company Limited will fully and unconditionally guarantee the payment of principal, premium, if any, interest and additional amounts, if any, payable in respect of the Notes.                                                                                                                                                                                                                                                                                                                                                            |
| Offering price                                  |     | For the 2035 Notes:             % of the principal amount;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
 For the 2055 Notes:             % of the principal amount                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
 plus, in each case, accrued interest, if any, from            , 2025.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |
| Maturity                                        |     | For the 2035 Notes:             , 2035; and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
 For the 2055 Notes:             , 2055.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |
| Status of the Notes and Guarantee/Ranking       |     | Each series of the Notes will be TUSFI’s direct, unsecured and unsubordinated general obligations and will have the same rank in liquidation as all of its other current and future unsecured and unsubordinated obligations. The Guarantee will be the direct, unsecured and unsubordinated general obligation of TPC and will have the same rank in liquidation as all of its other current and future unsecured and unsubordinated obligations.                                                                                                             |
| Minimum denomination                            |     | Each series of the Notes will be in denominations of $200,000 and integral multiples of $1,000 in excess thereof. No Notes will be sold in the offering to any