Company: ARVN
Filing Date: 2025-04-29
Form Type: DEF 14A
Source: 0001655759-25-000075
Chunk: 2

Company: ARVINAS, INC.
Filing Date: 2025-04-29
Form: DEF 14A
Chunk 2
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 printed copy of the proxy materials, by completing, signing and dating the proxy card provided to you and returning it in the prepaid envelope provided to you; or

#### •

#### Vote at the Annual Meeting.
If your shares are held in “street name,” that is, held for your account by a bank, broker or other nominee, you will receive instructions from the holder of record that you must follow for your shares to be voted.

The rules a nd procedures applicable to the Annual Meeting, together with a list of stockholders of record for inspection for any purpose germane to the Annual Meeting will be available for the participating stockholders of record at www.virtualshareholdermeeting.com/ARVN2025.

Your vote is very important. Whether or not you plan to attend the Annual Meeting, we urge you to take the time to submit a proxy to vote your shares.

|                        |     | By order of the Board of Directors,                |
|                        |     | /s/ John Houston, Ph.D.                            |
|                        |     | John Houston, Ph.D.                                |
|                        |     | Chairperson, President and Chief Executive Officer |
| New Haven, Connecticut |     |                                                    |
| April 29, 2025         |     |                                                    |

#### Arvinas, Inc.

#### Proxy Statement
|                                                                                                                                                                           |     | Page |
| PROXY STATEMENT                                                                                                                                                           |     |    1 |
| IMPORTANT INFORMATION ABOUT THE ANNUAL MEETING AND VOTING                                                                                                                 |     |    2 |
| PROPOSAL NO. 1—ELECTION OF THREE CLASS IDIRECTORS                                                                                                                         |     |    6 |
| CORPORATE GOVERNANCE                                                                                                                                                      |     |   15 |
| PROPOSAL NO. 2—ADVISORY VOTE ON EXECUTIVE COMPENSATION                                                                                                                    |     |   24 |
| EXECUTIVE AND DIRECTOR COMPENSATION                                                                                                                                       |     |   25 |
| PROPOSAL NO. 3—RATIFICATION OF THE APPOINTMENT OF DELOITTE & TOUCHE LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE FISCAL YEAR ENDING DECEMBER 31, 2025 |     |   64 |
| REPORT OF THE AUDIT COMMITTEE                                                                                                                                             |     |   66 |
| PRINCIPAL STOCKHOLDERS                                                                                                                                                    |     |   67 |
| TRANSACTIONS WITH RELATED PERSONS                                                                                                                                         |