Company: SCLXW
Filing Date: 2025-01-21
Form Type: 424B3
Source: 0000950170-25-007391
Chunk: 2

Company: Scilex Holding Co
Filing Date: 2025-01-21
Form: 424B3
Chunk 2
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Recent Developments—Settlement Agreement” for additional information.

Our Common Stock is listed on the Nasdaq Capital Market under the symbol “SCLX”. On January 17, 2025, the last reported sales price per share of our Common Stock was $0.45.

This prospectus supplement updates and supplements the information in the Prospectus and is not complete without, and may not be delivered or utilized except in combination with, the Prospectus, including any amendments or supplements thereto. This prospectus supplement should be read in conjunction with the Prospectus and if there is any inconsistency between the information in the Prospectus and this prospectus supplement, you should rely on the information in this prospectus supplement.

See the section entitled “Risk Factors” beginning on page 17 of the Prospectus as well as risks and uncertainties described under similar headings in any amendments or supplements to the Prospectus to read about factors you should consider before buying our securities.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus supplement or the Prospectus. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus supplement is January 21, 2025

UNITED STATES
SECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549

_______________________

FORM 8-K_______________________

CURRENT REPORT
PURSUANT TO SECTION 13 OR 15(d)
OF THE SECURITIES EXCHANGE ACT OF 1934

Date of Report (Date of earliest event reported): January 21, 2025

_______________________SCILEX HOLDING COMPANY(Exact name of registrant as specified in its charter)_______________________</div>

| Delaware                     
 (State or other jurisdiction 
 of incorporation)            | 001-39852    
 (Commission  
 File Number) | 92-1062542          
 (IRS Employer       
 Identification No.) |

<div align='center'>960 San Antonio Road, Palo Alto, California, 94303
(Address of principal executive offices, including zip code)

Registrant’s telephone number, including area code: (650) 516-4310

N/A
(Former name or former address, if changed since last report)

_______________________</div>

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

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