Company: SMNR
Filing Date: 2025-08-13
Form Type: 424B3
Source: 0001193125-25-179226
Chunk: 1002

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-08-13
Form: 424B3
Chunk 1002
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 connection with the
signing of this waiver by independent legal counsel selected by the respective party and that such party has discussed the legal consequences and import of this waiver with legal counsel. Each of the parties to this Support Agreement further
acknowledge that each has read and understands the meaning of this waiver and grants this waiver knowingly, voluntarily, without duress and only after consideration of the consequences of this waiver with legal counsel.

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E-5

IN WITNESS WHEREOF, Stockholder, Parent and the Company have each caused this Stockholder Support Agreement to be duly executed as of the date first written above.

| STOCKHOLDER:                     |     |                         |
| Scilex Holding Company           |     |                         |
| By:                              |     | /s/ Henry Ji, Ph.D.     |
| Name:                            |     | Henry Ji, Ph.D.         |
| Title:                           |     | Executive Chairperson   |
| COMPANY:                         |     |                         |
| Semnur Pharmaceuticals, Inc.     |     |                         |
| By:                              |     | /s/ Jaisim Shah         |
| Name:                            |     | Jaisim Shah             |
| Title:                           |     | Chief Executive Officer |
| PARENT:                          |     |                         |
| Denali Capital Acquisition Corp. |     |                         |
| By:                              |     | /s/ Lei Huang           |
| Name:                            |     | Lei Huang               |
| Title:                           |     | Chief Executive Officer |

E-6

Exhibit A Stockholders

| Stockholder            |     | Number of Shares |     | Address for Notices        |
| Scilex Holding Company |     |      160,000,000 |     | 960 San Antonio Road       
 Palo Alto, CA 94303 Email: 
 jshah@scilexholding.com    |

E-7

Annex F

AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT

THIS AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of
[ ], 2024, is made and entered into by and among (i) Semnur Pharmaceuticals, Inc., a Delaware corporation (formerly known as Denali Capital Acquisition Corp.) (the “Company”), (ii) the
equityholders designated as Existing Holders on Schedule A hereto (collectively, the “Existing Holders”) and (iii) Scilex Holding Company (