Company: SCLXW
Filing Date: 2025-05-07
Form Type: POS AM
Source: 0001193125-25-115095
Chunk: 148

Company: Scilex Holding Co
Filing Date: 2025-05-07
Form: POS AM
Chunk 148
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 to operate our business effectively or at comparable costs, and our profitability may decline. Risks Related to Ownership of our Common Stock The market price of our Common Stock may fluctuate significantly, and investors in our Common Stock may lose all or a part of their investment. The market prices for securities of biotechnology and pharmaceutical companies have historically been highly volatile, and the market has from time to time experienced significant price and volume fluctuations that are unrelated to the operating performance of particular companies. For example, from November 11, 2022 (the first trading day following the closing of the Business Combination) to May 5, 2025, our closing stock price ranged from $3.99 to $518.00. The market price of our Common Stock may fluctuate significantly in response to numerous factors, some of which are beyond our control, such as:

| • |     | our ability to commercialize ZTlido, GLOPERBA, ELYXYB or our product candidates, if approved; |

| • |     | legal disputes or other developments relating to proprietary rights, including patents, litigation matters and our ability to obtain patent protection for ZTlido, GLOPERBA, ELYXYB or our product candidates, government investigations and the results of any proceedings or lawsuits, including, but not limited to, patent or stockholder litigation; |

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| • |     | extension of the lock-up restriction by court order in the Chapter 11 Cases (as defined below) on the 76,000,000 shares (on a pre-Reverse Stock Split basis) of our Common Stock that were previously distributed by Sorrento to Sorrento equityholders as a dividend; |

| • |     | announcements of the introduction of new products by our company and our competitors; |

| • |     | issuances of debt or equity securities; |

| • |     | market conditions and trends in the pharmaceutical and biotechnology sectors; |

| • |     | overall performance of the equity markets and other factors that may be unrelated to our operating performance or the operating performance of our competitors, including changes in market valuations of similar companies; |

| • |     | trading volume of our Common Stock; |

| • |     | ineffectiveness of our internal controls; and |

| • |     | other events or factors, many of which are beyond our control. |

See the risk factor below titled “ If our operations and performance do not meet the expectations of investors or securities analysts, the market price