Company: SMNR
Filing Date: 2025-12-03
Form Type: S-8
Source: 0001193125-25-306962
Chunk: 27

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-12-03
Form: S-8
Chunk 27
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 unless
in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be
governed by the final adjudication of such issue.

II- 4

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the Palo Alto, State of California, on December 3, 2025.

| Semnur Pharmaceuticals, Inc.                 |     |                 |
| By:                                          |     | /s/ Jaisim Shah |
| Name: Jaisim Shah                            |     |                 |
| Title: Chief Executive Officer and President |     |                 |

POWER OF ATTORNEY K NOWA LLP ERSONSB YT HESEP RESENTS ,that each person whose signature appears below constitutes and appoints Jaisim Shah and Stephen Ma, and each or any one of them, as his or her true and lawful attorneys-in-factand agent, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-factand agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-factand agents, or any of them, or their or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

| SIGNATURE                   
 /s/ Jaisim Shah             |     | TITLE                                                        
 Chief Executive Officer, President and Director              
 (Principal Executive Officer)                                |     | DATE             
 December 3,