Company: SHPH
Filing Date: 2025-04-10
Form Type: PRER14A
Source: 0001641172-25-003635
Chunk: 53

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-04-10
Form: PRER14A
Chunk 53
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, effective as of the Effective Date:

| 1. | Section                                    
 3(a) is hereby amended to read as follows: |

“(a) Subject to the provisions
of Section 14 hereof, the maximum aggregate number of Shares that may be awarded and sold under the Plan (the “Share Authorization”)
shall be equal to the sum of (i) five million (5,000,000) Shares; plus (ii) three million (3,000,000) Shares, which is the number of
shares that were authorized for grant under the Plan as originally adopted. The Shares may be authorized, but unissued, or reacquired
Common Stock.”

| 2. | Except                                                                                 
 as specifically set forth herein, the terms of the Plan shall be and remain unchanged. |

<div align='center'>[Signature Page Follows]</div>

IN WITNESS THEREOF, the undersigned has executed this Amendment No. 1 to the Shuttle Pharmaceuticals Holdings, Inc. 2018 Equity Incentive Plan.

| By:    |                         |
| Name:  | Christopher             
 Cooper                  |
| Title: | Interim                 
 Chief Executive Officer |
| Date:  | _________________,      
 2025                    |