Company: DMAC
Filing Date: 2025-08-01
Form Type: S-3
Source: 0001437749-25-024290
Chunk: 0

Company: DiaMedica Therapeutics Inc.
Filing Date: 2025-08-01
Form: S-3
Chunk 0
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<div align='center'>As filed with the U.S. Securities and Exchange Commission on August 1, 2025</div>

Registration Statement No. 333-_________

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION
<div align='center'>Washington, D.C. 20549

FORM S-3

REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

DIAMEDICA THERAPEUTICS INC.

(Exact name of registrant as specified in its charter)</div>

| British Columbia, Canada        | Not Applicable        |
| (State or other jurisdiction of 
 incorporation or organization)  | -I.R.S. Employer      
 Identification Number |

<div align='center'>301 Carlson Parkway, Suite 210

Minneapolis, Minnesota 55305

(763) 496-5454

(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

Rick Pauls

President and Chief Executive Officer

DiaMedica Therapeutics Inc.

301 Carlson Parkway, Suite 210

Minneapolis, Minnesota 55305

(763) 496-5454

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copies to:</div>

| Matthew W. Mamak           | Keith Inman               |
| Alston & Bird LLP          | Pushor Mitchell LLP       |
| 90 Park Avenue, 14th Floor | 301 - 1665 Ellis Street   |
| New York, New York 10016   | Kelowna, British Columbia |
| (212) 210-1256             | Canada V1Y 2B3            |
|                            | (250) 762-2108            |

Approximate date of commencement of proposed sale to the public: From time to time after this registration statement becomes effective.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box: ☑

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number