Company: TEM
Filing Date: 2025-08-27
Form Type: 424B7
Source: 0001193125-25-189854
Chunk: 2

Company: Tempus AI, Inc.
Filing Date: 2025-08-27
Form: 424B7
Chunk 2
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 INFORMATION BY REFERENCE |     |      | S-15 |

Prospectus

|                                                   |     | Page |     |
| ABOUT THIS PROSPECTUS                             |     |      |   i |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |      | iii |
| PROSPECTUS SUMMARY                                |     |      |   1 |
| RISK FACTORS                                      |     |      |   4 |
| USE OF PROCEEDS                                   |     |      |   5 |
| SELLING STOCKHOLDERS                              |     |      |   6 |
| PLAN OF DISTRIBUTION                              |     |      |   8 |
| LEGAL MATTERS                                     |     |      |  11 |
| EXPERTS                                           |     |      |  11 |
| WHERE YOU CAN FIND MORE INFORMATION               |     |      |  11 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE |     |      |  12 |

ABOUT THIS PROSPECTUS SUPPLEMENT

This prospectus supplement is part of a registration statement on Form S-3 that we filed with the
Securities and Exchange Commission (the “SEC”) utilizing a “shelf” registration process as a “well-known seasoned issuer” as defined in Rule 405 under the Securities Act of 1933, as amended (the “Securities
Act”). Under this shelf registration process, the selling stockholders may offer shares of our Class A common stock in one or more offerings. There is no limit on the aggregate number of shares of Class A common stock that the
selling stockholders may offer pursuant to the registration statement of which this prospectus supplement is a part.

The selling
stockholders referenced in this prospectus supplement may offer and sell up to 1,268,033 shares of our Class A common stock pursuant to this prospectus supplement. We may also authorize one or more free writing prospectuses to be provided to
you that may contain material information relating to this offering. Any related free writing prospectus that we may authorize to be provided to you may also add, update or change any of the information contained in this prospectus supplement or in
the documents that we have incorporated by reference into this prospectus supplement. We urge you to read carefully this prospectus supplement and the accompanying prospectus, together with the information incorporated herein by reference as
described in the section titled “Incorporation of Certain Information by Reference,” before buying any of the securities