Company: SNSE
Filing Date: 2025-03-28
Form Type: S-8
Source: 0000950170-25-046346
Chunk: 0

Company: Sensei Biotherapeutics, Inc.
Filing Date: 2025-03-28
Form: S-8
Chunk 0
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<div align='center'>As filed with the U.S. Securities and Exchange Commission on March 28, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

_____________________________________

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

_____________________________________

SENSEI BIOTHERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)

_____________________________________</div>

| Delaware                        |     | 83-1863385         |
| (State or other jurisdiction of 
 Incorporation or organization)  |     | -I.R.S. Employer   
 Identification No. |

<div align='center'>1405 Research Blvd, Suite 125
Rockville, MD 20850

(Address of principal executive offices) (Zip code)

_____________________________________

2021 Equity Incentive Plan

2021 Employee Stock Purchase Plan

(Full title of the plan)

_____________________________________

John Celebi

President and Chief Executive Officer

Sensei Biotherapeutics, Inc.

1405 Research Blvd, Suite 125,
Rockville, MD 20850

(240) 243-8000

(Name and address of agent for service) (Telephone number, including area code, of agent for service)

Copies to:</div>

| Mark BallantyneCooley LLP 
 11951 Freedom Drive       
 Reston, VA 20190-5640     
 (703) 456-8000            |     | Christopher W. Gerry                              
 General Counsel and Secretary                     
 Sensei Biotherapeutics, Inc.                      
 1405 Research Blvd, Suite 125 Rockville, MD 20850 
 (240) 243-8000                                    |

<div align='center'>_____________________________________</div>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer ☐ | Accelerated filer ☐         |
| Non-accelerated filer ☒   | Smaller reporting company ☒ |
|                           | Emerging growth company ☒   |

If an