Company: CMA
Filing Date: 2025-10-09
Form Type: 425
Source: 0001193125-25-235941
Chunk: 5

Company: COMERICA INC
Filing Date: 2025-10-09
Form: 425
Chunk 5
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 Registration Statement on Form S-4that will include a joint proxy statement of Fifth Third and Comerica and a prospectus of Fifth Third, as well as in the Annual Reports on Form 10-K,Quarterly Reports on Form 10-Q,Current Reports on Form 8-Kand other filings that each of Fifth Third and Comerica makes with the Securities and Exchange Commission (the “SEC”). The foregoing description of the Merger Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Merger Agreement, which is attached hereto as Exhibit 2.1 and is incorporated herein by reference.

| ITEM 9.01 | FINANCIAL STATEMENTS AND EXHIBITS. |

(d) Exhibits

| 2.1* |     | Agreement and Plan of Merger, dated as of October 5, 2025, by and among Fifth Third Bancorp, Fifth Third Financial Corporation, Comerica Incorporated and Comerica Holdings Incorporated. |
|:-----|:----|:------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 104  |     | Cover Page Interactive Data File (embedded within the Inline XBRL document).                                                                                                              |

| * | Schedules have been omitted pursuant to Item 601(a)(5) of Regulation                                                                                                                                                                                                           
 S-K. A copy of any omitted schedule will be furnished supplementally to the SEC upon request; provided, however, that the parties may request confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended, for any document so furnished. |

FORWARD-LOOKING STATEMENTS

This communication contains statements that constitute “forward-looking statements” within the meaning of, and subject to the protections of,
Section 27A of the Securities Act, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can
be identified by words such as “achieve,” “anticipate,” “assume,” “believe,” “could,” “deliver,” “drive,” “enhance,” “estimate,”
“expect,” “focus,” “future,” “goal,” “grow,” “guidance,” “intend,” “may,” “might,” “plan,” “position,”
“potential,” “predict,” “project,” “opportunity,” “outlook,” “should,” “strategy