Company: PACB
Filing Date: 2025-03-17
Form Type: S-8
Source: 0001299130-25-000063
Chunk: 1

Company: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
Filing Date: 2025-03-17
Form: S-8
Chunk 1
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 growth company   |     | o |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. o

### EXPLANATORY NOTE
This Registration Statement on Form S-8 (the “Registration Statement”) is being filed by Pacific Biosciences of California, Inc., a Delaware corporation (the “Registrant”), for the purpose of registering an additional 4,000,000 shares of common stock, par value $0.001 per share (the “Common Stock”), that were reserved for issuance under the Company’s 2010 Employee Stock Purchase Plan (the “2010 ESPP”). The Registrant previously filed with the Securities and Exchange Commission (the “Commission”) Registration Statements on Forms S-8 on October 29, 2010 (SEC File No. 333-170211), March 1, 2012 (SEC File No. 333-179810), January 17, 2013 (SEC File No. 333-186065), January 21, 2014 (SEC File No. 333-193437), January 23, 2015 (SEC File No. 333-201678), January 28, 2016 (SEC File No. 333-209157), January 26, 2017 (SEC File No. 333-215746), January 25, 2018 (SEC File No. 333-222696), January 25, 2019 (SEC File No. 333-229368), January 24, 2020 (SEC File No. 333-236061), March 1, 2021 (SEC File No. 333-253669), February 28, 2022 (SEC File No. 333-263101), February 28, 2023 (SEC File No. 333-270122), and February 29, 2024 (SEC File No. 333-277486) (collectively, the “Prior Registration Statements”) registering shares of Common Stock issuable under the 2010 ESPP. This Registration Statement relates to securities of the same class as those to which the Prior Registration Statements relate and is submitted in accordance with General Instruction E of Form S-8 regarding Registration of Additional Securities. Pursuant to General Instruction E of Form S-8, the