Company: HURA
Filing Date: 2025-12-10
Form Type: 424B5
Source: 0001193125-25-313799
Chunk: 26

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-12-10
Form: 424B5
Chunk 26
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 this prospectus will provide the
specific terms of the plan of distribution for securities to be offered by us or by the selling stockholders.

Our common stock, par value
$0.001 per share (“Common Stock”), is traded on the Nasdaq Capital Market under the symbol “HURA.” On November 20, 2025, the last reported sales price of our Common Stock was $1.59 per share.

Investment in our securities involves risks. Please read carefully the section entitled “ Risk Factors” in our most recent Annual Report on Form 10-Kand in any applicable prospectus supplement and/or other offering material for a discussion of certain factors which should be considered in an investment of the securities which may be offered hereby.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is November 22, 2025.

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS                                |     |  1 |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |  2 |
| TUHURA BIOSCIENCES, INC.                             |     |  4 |
| DESCRIPTION OF SECURITIES WE MAY OFFER               |     |  5 |
| USE OF PROCEEDS                                      |     |  5 |
| RISK FACTORS                                         |     |  5 |
| DESCRIPTION OF DEBT SECURITIES                       |     |  6 |
| DESCRIPTION OF CAPITAL STOCK                         |     | 16 |
| DESCRIPTION OF WARRANTS                              |     | 20 |
| DESCRIPTION OF SUBSCRIPTION RIGHTS                   |     | 21 |
| DESCRIPTION OF UNITS                                 |     | 22 |
| DESCRIPTION OF PURCHASE CONTRACTS                    |     | 22 |
| LEGAL OWNERSHIP OF SECURITIES                        |     | 23 |
| SELLING STOCKHOLDERS                                 |     | 26 |
| PLAN OF DISTRIBUTION                                 |     | 33 |
| LEGAL MATTERS                                        |     | 38 |
| EXPERTS                                              |     | 38 |
| WHERE YOU CAN FIND MORE INFORMATION                  |     | 38 |

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ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement that we filed with the Securities and Exchange Commission, or SEC, using a
“shelf” registration process. Under this shelf registration process