Company: FITBI
Filing Date: 2025-03-21
Form Type: S-3ASR
Source: 0001193125-25-060230
Chunk: 2

Company: FIFTH THIRD BANCORP
Filing Date: 2025-03-21
Form: S-3ASR
Chunk 2
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 by the applicable prospectus supplement.

Our principal executive offices are located at 38 Fountain Square Plaza, Cincinnati,
Ohio 45263, and our telephone number at that address is 800-972-3030.

Investing in these securities involves certain risks. See the information included and incorporated herein by reference and any accompanying prospectus supplement for a discussion of the factors you should carefully consider before deciding to purchase these securities, including the information under “Risk Factors” included in our annual report on Form 10-Kfor the year ended December 31, 2024.

These securities will be our equity securities or unsecured obligations, will not be savings accounts, deposits or other obligations of any bank or savings association, and will not be insured by the Federal Deposit Insurance Corporation, the bank insurance fund or any other governmental agency or instrumentality.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined that this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this
prospectus is March 21, 2025.

TABLE OF CONTENTS Page

| About this Prospectus               |     | 3 |
| Where You Can Find More Information |     | 4 |
| Fifth Third Bancorp                 |     | 5 |
| Use of Proceeds                     |     | 5 |
| Plan of Distribution                |     | 6 |
| Validity of Securities              |     | 8 |
| Experts                             |     | 8 |

Unless the context requires otherwise, references to “we,” “us,” “our” or similar terms are to Fifth Third Bancorp and its subsidiaries. 2

ABOUT THIS PROSPECTUS

This prospectus is a part of a registration statement that we filed with the Securities and Exchange Commission (“SEC”) using a
“shelf” registration process. Under this shelf registration statement, we may sell, either separately or together, subordinated debt securities, senior debt securities, warrants, stock purchase contracts, units, preferred stock, depositary
shares representing interests in preferred stock, and common stock in one or more offerings.

Each time we sell securities, we will
provide a prospectus supplement that will contain specific information about the terms of that offering. The prospectus supplement may also add, update or change information contained in this prospectus. You should read this prospectus and the
applicable prospectus supplement together with the additional information described under the heading “Where You Can Find More Information.”