Company: IOBT
Filing Date: 2025-07-24
Form Type: S-3
Source: 0001193125-25-164495
Chunk: 18

Company: IO Biotech, Inc.
Filing Date: 2025-07-24
Form: S-3
Chunk 18
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 |     | ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers; |

| • |     | block trades in which the broker-dealer will attempt to sell shares of our common stock as agent, but may 
 position and resell a portion of the block as principal to facilitate the transaction;                    |

| • |     | purchases by a broker-dealer as principal and resale by the broker-dealer for its account; |

| • |     | an over-the-counter distribution; |

| • |     | an exchange distribution in accordance with the rules of the applicable exchange; |

| • |     | privately negotiated transactions; |

| • |     | short sales effected after the effective date of the registration statement of which this prospectus forms a 
 part;                                                                                                        |

| • |     | through the writing or settlement of options or other hedging transactions, whether through an options exchange 
 or otherwise;                                                                                                   |

| • |     | broker-dealers may agree with the selling stockholders to sell a specified number of such shares at a stipulated 
 price per share;                                                                                                 |

| • |     | a combination of any such methods of sale; or |

| • |     | any other method permitted pursuant to applicable law. |

The selling stockholders may, from time to time, pledge or grant a security interest in some or all of the shares of our common stock owned by them and, if they default in the performance of their secured obligations, the pledgees or secured parties may offer and sell the shares of our common stock, from time to time, under this prospectus, or under an amendment to this prospectus under Rule 424(b)(3) or other applicable provision of the Securities Act amending the list of selling stockholders to include the pledgee, transferee, or other successors in interest as selling stockholder under this prospectus. The selling stockholders also may transfer the shares of our common stock in other circumstances, in which case the transferees, pledgees or other successors in interest will be the selling beneficial owners for purposes of this prospectus. In connection with the sale of shares of our common stock or interests therein, the selling stockholders may enter into hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short 13

sales of shares of our common stock in the course of hedging the positions they assume. The selling stockholders may also sell shares of our common stock short and deliver these securities to
close out its short