Company: ZVRA
Filing Date: 2025-03-13
Form Type: S-8
Source: 0001437749-25-007343
Chunk: 1

Company: ZEVRA THERAPEUTICS, INC.
Filing Date: 2025-03-13
Form: S-8
Chunk 1
---
planatory Note</div>

This Registration Statement on Form S-8 is being filed for the purpose of registering anadditional 2,146,828 shares of the Registrant’s Common Stock to be issued pursuant to the Registrant’s Amended and Restated 2014 Equity Incentive Plan (the " A&R 2014 Plan"). A Registration Statement of the Registrant on Form S-8 relating to the A&R 2014 Plan is effective.

<div align='center'>INCORPORATION BY REFERENCE OF CONTENTS OF REGISTRATION

STATEMENTS ON FORM S-8</div>

The contents of the Registration Statements on Form S-8 (File Nos. 333-203703, 333-210369, 333-216858, 333-224062, 333-230041, 333-236794, 333-252743, 333-257429, 333-270340, and 333-278444), including any amendments thereto, as filed with the Securities and Exchange Commission (the “ Commission”), are incorporated herein by reference and made a part of this Registration Statement.

<div align='center'>3</div>

ITEM8. EXHIBITS

| Exhibit 
 Number  | Description of the Exhibit                                                                                                                                                                                                                                                     |
| 4.1     | Amended and Restated Certificate of Incorporation of the Registrant (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K (File No. 001-36913) filed on April 21, 2015)                                                                     |
| 4.2     | Certificate of Amendment of Amended and Restated Certificate of Incorporation of the Registrant, effective as of December 23, 2020 (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-36913) filed on December 23, 2020)   |
| 4.3     | Certificate of Amendment of Certificate of Incorporation of the Registrant, effective as of February 21, 2023 (incorporated by reference to Exhibit 3.1 to the Registrant's Current Report on Form 8-K (File No. 001-36913) filed on February 24, 2023)                        |
| 4.4     |                                                                                                                                                                                                                                                                                |
| 5.1*    | Opinion of Latham and Watkins LLP