Company: RNLXY
Filing Date: 2025-07-25
Form Type: S-8 POS
Source: 0001213900-25-067773
Chunk: 0

Company: Renalytix plc
Filing Date: 2025-07-25
Form: S-8 POS
Chunk 0
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Registration No. 333-248741

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

POST-EFFECTIVE AMENDMENT NO. 1

TO

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

Renalytix plc

(Exact name of registrant as specified in
its charter)</div>

| England and Wales                              |     | Not applicable                      |
| (State or other jurisdiction of incorporation) |     | -I.R.S. Employer Identification No. |

<div align='center'>2 Leman Street

London E1W 9US

United Kingdom

(Address of principal executive
offices) (Zip Code)

Renalytix AI plc Share Option Plan for Employees with Non-Employee Sub-Plan and U.S. Sub-Plan

Renalytix AI plc 2020 Employee Share Purchase Plan

Renalytix AI plc 2020 Equity Incentive Plan

(Full title of the plan)

Renalytix AI, Inc.

1460 Broadway

New York, NY 10036

Tel: +1 646 397 3970

(Name, address and telephone number,
including area code, of agent for service)

Copies to:

Mark E. Rosenstein

Derick S. Kauffman

Stevens & Lee, P.C.

620 Freedom Business Center, Suite 200

King of Prussia, PA 19406

(610) 205-6000</div>

Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions
of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging
growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer ☐   | Accelerated filer ☐       | Non-accelerated filer ☒ |
| Smaller reporting company ☒ | Emerging growth company ☒ |                         |

If an emerging growth company, indicate by
check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
standards provided pursuant to Section 13(a) of the Exchange Act. ☐

This Registration Statement shall become effective upon