Company: NOTV
Filing Date: 2025-08-29
Form Type: S-3
Source: 0001628280-25-041413
Chunk: 0

Company: Inotiv, Inc.
Filing Date: 2025-08-29
Form: S-3
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on August 29, 2025</div>

#### Registration No. 333-

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION
<div align='center'>Washington, D.C. 20549</div>

#### FORM S-3

### REGISTRATION STATEMENT

#### UNDER

#### THE SECURITIES ACT OF 1933

#### INOTIV, INC.
<div align='center'>(Exact name of registrant as specified in its charter)</div>

| Indiana                                          |     | 35-1345024                         |
| (State or other jurisdiction of incorporation or 
 organization)                                    |     | -I.R.S Employer Identification No. |

#### 2701 Kent Avenue

#### West Lafayette, Indiana 47906-1382
<div align='center'>(765) 463-4527

(Address, including zip code, and telephone number, including area code, of registrant’s principal executive office)</div>

#### Beth Taylor

### Chief Financial Officer and

#### Executive Vice President

#### Inotiv, Inc.

#### 2701 Kent Avenue

#### West Lafayette, Indiana 47906-1382
<div align='center'>(765) 463-4527

(Name, address, including zip code, and telephone number, including area code, of agent for service)

With copies to:</div>

#### Griffin D. Foster

#### Christine G. Long

#### Faegre Drinker Biddle & Reath LLP

#### 600 East 96th Street, Suite 600

#### Indianapolis, Indiana 46240
<div align='center'>(317) 569-9600

From time to time after the effectiveness of this registration statement (Approximate date of commencement</div>

#### of proposed sale to the public)
If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box: ☒

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same