Company: TVRD
Filing Date: 2025-11-13
Form Type: 424B3
Source: 0001104659-25-111336
Chunk: 200

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-11-13
Form: 424B3
Chunk 200
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| † | Filed herewith. |

| * | This certification is deemed not filed for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference into any filing under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended. |

| ‡ | Schedules and exhibits have been omitted pursuant to Item 601(a)(5) of Regulation S-K. The registrant undertakes to furnish supplemental copies of any of the omitted schedules upon request by the SEC. |

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<div align='center'>118</div>

Table of Contents

<div align='center'>SIGNATURES</div>

Pursuant to the requirements of the Securities Exchange
Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, duly authorized.

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| ​                       | ​                         | ​                            |
| ​                       | TVARDI THERAPEUTICS, INC. |                              |
| ​                       | ​                         | ​                            |
| Date: November 13, 2025 | By:                       | /s/ IMRAN ALIBHAI            |
| ​                       | Name:                     | Imran Alibhai                |
| ​                       | Title:                    | Chief Executive Officer      |
| ​                       | ​                         | -Principal Executive Officer |
| ​                       | ​                         | ​                            |
| Date: November 13, 2025 | By:                       | /s/ DAN CONN                 |
| ​                       | Name:                     | Dan Conn                     |
| ​                       | Title:                    | Chief Financial Officer      |
| ​                       | ​                         | -Principal Financial Officer |
| ​                       | ​                         | ​                            |

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<div align='center'>119</div>

EXHIBIT 31.1

<div align='center'>Certification of Chief Executive Officer Pursuant to

Rule 13a-14(a) under the Securities Exchange Act

of 1934, as Adopted Pursuant to

Section 302 of the Sarbanes-Oxley Act of 2002</div>

I, Imran Alibhai, certify that:

1. I have reviewed this Quarterly Report on Form 10-Q of Tvardi Therapeutics,
Inc.;

2. Based on my knowledge