Company: SCLXW
Filing Date: 2025-12-01
Form Type: 424B3
Source: 0001193125-25-303054
Chunk: 4

Company: Scilex Holding Co
Filing Date: 2025-12-01
Form: 424B3
Chunk 4
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 to be complete and is qualified in its entirety by reference to the full text of the Datavault SPA, a copy of which is filed herewith as Exhibit 10.1 and is incorporated herein by reference.

| Item 7.01. | Regulation FD Disclosure. |

On November 26, 2025, the Company issued a press release announcing the Subsequent Closing under the Datavault SPA. A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-Kand is incorporated herein by reference. The information in Item 7.01 of this Current Report on Form 8-K (including Exhibit99.1 attached hereto) is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall they be deemed incorporated by reference into any filing by the Company, under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing.

| Item 9.01. | Financial Statements and Exhibits. |

(d) Exhibits.

| Exhibit 
 Number  
 10.1#   
 99.1    |     | Description                                                                                                                                                                                                                               
 Securities Purchase Agreement, dated September 25, 2025, by and between Scilex Holding Company and Datavault AI Inc. (incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K filed on September 26, 2025). 
 Press release dated November 26, 2025.                                                                                                                                                                                                    |
|:--------|:----|:------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 104     |     | Cover Page Interactive Data File, formatted in Inline Extensible Business Reporting Language (iXBRL).                                                                                                                                     |

| 

# | Certain of the exhibits and schedules to this Exhibit have been omitted in accordance with Regulation S-K Item 601. The Company agrees to furnish a copy of all omitted exhibits and schedules to the SEC upon its request. |
SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

| SCILEX HOLDING COMPANY                     |     |                     |
| By:                                        |     | /s/ Henry Ji, Ph.D. |
|