Company: RGNX
Filing Date: 2025-03-13
Form Type: S-8
Source: 0000950170-25-038862
Chunk: 0

Company: REGENXBIO Inc.
Filing Date: 2025-03-13
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on March 13, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

REGENXBIO Inc.

(Exact name of registrant as specified in its charter)</div>

| Delaware                                                      | 47-1851754                         |
| (State or other jurisdiction ofincorporation or organization) | -I.R.S. EmployerIdentification No. |
| 9804 Medical Center DriveRockville, Maryland 20850            |                                    |
| (Address of Principal Executive Offices and Zip Code)         |                                    |

<div align='center'>2015 Equity Incentive Plan

(Full title of the plans)

Mitchell Chan

Chief Financial Officer

REGENXBIO Inc.

9804 Medical Center Drive

Rockville, Maryland 20850

(Name and address of agent for service)

(240) 552-8181

(Telephone number, including area code, of agent for service)

Copies to:</div>

| Kerry Shannon Burke     | Patrick J. Christmas      |
| Matthew C. Franker      | Chief Legal Officer       |
| Covington & Burling LLP | REGENXBIO Inc.            |
| One CityCenter          | 9804 Medical Center Drive |
| 850 Tenth Street, N.W.  | Rockville, Maryland 20850 |
| Washington, D.C. 20001  | (240) 552-8181            |
| (202) 662-6000          |                           |

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b‑2 of the Exchange Act.

| Large accelerated filer |   | Accelerated filer         |  |
| Non-accelerated filer   |  | Smaller reporting company |  |
|                         |    | Emerging growth company   |  |

If an emerging growth company, indicate by check mark if