Company: XXII
Filing Date: 2025-11-04
Form Type: 424B5
Source: 0001493152-25-020754
Chunk: 15

Company: 22nd Century Group, Inc.
Filing Date: 2025-11-04
Form: 424B5
Chunk 15
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our common stock pursuant to this prospectus supplement will terminate upon the earlier of (i) the sale of all of our common
stock provided for in this prospectus supplement or (ii) termination of the sales agreement as provided therein.

Our common stock is listed on the Nasdaq Capital Market and trades under the symbol “XXII.” The transfer agent of our common stock is Continental Stock Transfer & Trust Company.

The Sales Agentand its affiliates may in the future provide various investment banking and other financial services for us and our affiliates, for which services they may in the future receive customary fees. In the course of its business, the Sales Agent may actively trade our securities for its own account or for the accounts of customers, and, accordingly, the Sales Agent may at any time hold long or short positions in such securities. To the extent required by Regulation M, the Sales Agent will not engage in any market making activities involving our common stock while the offering is ongoing under this prospectus supplement.

<div align='center'>Legal Matters</div>

The validity of the shares of our common stock being offered hereby will be passed upon for us by Foley & Lardner LLP, Jacksonville, Florida. Faegre Drinker Biddle & Reath LLP is acting as counsel for the Sales Agent in connection with various legal matters relating to the shares of common stock offered hereby.

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<div align='center'>Experts</div>

The consolidated financial statements incorporated in this Prospectus by reference to the Annual Report on Form 10-K for the year ended December 31, 2024, as amended, have been so incorporated in reliance on the report of Freed Maxick, P.C., an independent registered public accounting firm, given on the authority of said firm as experts in auditing and accounting.

<div align='center'>Where You Can Find More Information</div>

We file annual, quarterly and current reports, proxy statements and other information with the SEC. The SEC maintains an internet site that contains reports, proxy and information statements and other information regarding issuers, including ours, that file electronically with the SEC. The public can obtain any document that we file electronically with the SEC at www.sec.gov.

We are “incorporating by reference” specified documents that we file with the SEC, which means:

| ● | incorporated                                      
 documents are considered part of this prospectus; |

| ● | we                                                                                   
 are disclosing important information to you by referring you to those documents; and |

| ● | information                                                                                            
 we file with the SEC will