Company: REVB
Filing Date: 2025-04-04
Form Type: DRS
Source: 0001213900-25-029022
Chunk: 97

Company: REVELATION BIOSCIENCES, INC.
Filing Date: 2025-04-04
Form: DRS
Chunk 97
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 to promote reduced costs including better management of CKD. Post Surgical Infection Overview Despite efforts to monitor and prevent infection in hospital care settings, infections arise from a range of different causes including surgery, burn wounds, central line catheters or urinary catheters, and sepsis, as well as long courses of antibiotic treatment, which may lead to the development of methicillin -resistantStaphylococcus aureus resistant infection (“MRSA”). According to the most recent prevalence study data published by the Center for Disease Control and Prevention in 2015, approximately 3% of hospital patients suffered at least one infection, and there were approximately 687,000 infection cases in acute care settings resulting in approximately 72,000 deaths. According to the CDC, on any given day about 31 hospital patients has at least one healthcare -associatedinfection. A World Health Organization cooperative study which included 55 hospitals in 14 countries from four regions, approximately 8.7% of hospitalized patients developed infection within 48 hours of hospitalization (Tikhomirov 1987). The most common healthcare -associatedinfections are bloodstream infection, pneumonia, urinary tract infections, and surgical site infections. Post Burn Infection Overview Burns are injuries to the skin involving the two main layers – the thin outer epidermis and/or the thicker, deeper dermis. Burns can result from a variety of causes including fire, hot liquids, chemicals (such as from strong acids or strong bases), electricity, steam, radiation from X -raysor radiotherapy, sunlight, or ultraviolet light. Chemical burns can be divided into acid or alkali burns. Alkali burns tend to be more severe, causing more penetration deeper into the skin by liquefying the skin (liquefaction necrosis). Acid burns penetrate less because they cause a coagulation injury (coagulation necrosis). Electrical burns typically have small entry and exit wounds but may also comprise extensive internal organ injury or associated traumatic injuries. Thermal burns are the most common type of burn. Approximately 86% of burns are caused by thermal injury such as fire or hot liquid, while about 4% are electrical and 3% are chemical. Flame and scald burns are the leading cause of burns in children and adults. More adults are injured with flame burns, while children younger than five years old are more often injured with scald burns. Burn injuries more commonly affect people of low and middle income and people in low -incomecountries (Schaefer 2023). Every year