Company: SCLXW
Filing Date: 2025-12-16
Form Type: S-1
Source: 0001193125-25-319720
Chunk: 647

Company: Scilex Holding Co
Filing Date: 2025-12-16
Form: S-1
Chunk 647
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 per share. |

| • |     | On November 23, 2025, the Registrant entered into the Warrant Inducement Agreement with Armistice Capital Master Fund, Ltd., pursuant to which, among other things, the Registrant issued new warrants exercisable for an aggregate of 1,356,594 shares of Common Stock at an exercise price of $29.00 per share. Pursuant to an engagement letter with StockBlock Securities LLC (“StockBlock”), the Registrant also issued to certain designees of StockBlock warrants to purchase an aggregate of 72,352 shares of Common Stock at an exercise price of $29.00 per share. |

The Registrant issued the foregoing securities in transactions not involving an underwriter and not requiring registration under Section 5 of the Securities Act in reliance on the exemption afforded by Section 4(a)(2) thereof.

| • |     | On July 22, 2025, the Registrant entered into Warrant Exchange Agreements (each, a “Warrant Exchange Agreement” and collectively, the “Warrant Exchange Agreements”) with certain holders (the “Exchanging Warrant Holders”) of its existing Tranche B warrants to purchase shares of Common Stock (the “Existing Tranche B Warrants”). Pursuant to the Warrant Exchange Agreements, the Registrant and the Exchanging Warrant Holders, in reliance on Section 3(a)(9) of the Securities Act, effected a voluntary securities exchange whereby the Exchanging Warrant Holders exchanged the Existing Tranche B Warrants, which were exercisable for an aggregate of 107,142 shares of Common |

II-3

| Stock at an exercise price of $36.40 per share, originally issued pursuant to that certain Securities Purchase Agreement, dated October 7, 2024, by and among us and the investors named therein, for warrants to purchase an aggregate of 500,000 shares of Common Stock at an exercise price of $40.00 per share. |

The Registrant issued the foregoing securities in transactions not involving an underwriter and not requiring registration under Section 5 of the Securities Act in reliance on the exemption afforded by Section 3(a)(9) thereof. Item 16. Exhibits and Financial Statements Schedules.

| a) | Exhibits |

The following exhibits are filed as part of this registration statement:

| Exhibit 
 Number  |     | Description                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| 2.1

#    |     | Agreement and Plan of