Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
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Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
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Filed Pursuant to Rule 424(b)(3)
Registration No. 333-292157

PROSPECTUS

### SCILEX HOLDING COMPANY
Up to 500,000 Shares of Common Stock Issuable Upon the Exercise of Warrants

Up to 1,703,946 Shares of Common Stock

This prospectus relates to the issuance by us of up to an aggregate of 500,000 shares of our common stock, par value $0.0001 per share
(“Common Stock”), issuable upon the exercise of warrants to purchase up to an aggregate of 500,000 shares of our Common Stock (the “Exchange Warrants”).

This prospectus also relates to the offer and sale from time to time by the selling stockholders named herein (the “Selling
Stockholders”) of up to an aggregate of 1,703,946 shares of Common Stock (the “Resale Shares”), consisting of (i) up to 275,000 shares of Common Stock (the “September 2025 Warrant Shares”) issuable upon the
exercise of warrants to purchase up to an aggregate of 275,000 shares of Common Stock that were issued on September 30, 2025 (the “September 2025 Warrants”) and (ii) up to 1,428,946 shares of Common Stock (the “November
2025 Warrant Shares”) issuable upon the exercise of (A) a warrant to purchase up to an aggregate of 1,356,594 shares of Common Stock (the “November 2025 Investor Warrant”) and (B) placement agent warrants to purchase up
to an aggregate of 72,352 shares of Common Stock (the “November 2025 Placement Agent Warrants” and together with the November 2025 Investor Warrant, the “November 2025 Warrants”) that were each issued on November 25,
2025.

We will not receive the proceeds from the resale of the Resale Shares hereunder; however, we will receive the proceeds from the
exercise of any Exchange Warrants, September 2025 Warrants, and November 2025 Warrants.

The Exchange Warrants were issued on July 28,
2025, pursuant to the warrant exchange agreements (each, a “Warrant Exchange Agreement” and collectively, the “Warrant Exchange Agreements”) that we entered into on July 22, 2025 with certain holders (the “Tranche
B Investors”) of the Company’s existing