Company: SUPN
Filing Date: 2025-07-28
Form Type: SC TO-T/A
Source: 0001104659-25-071028
Chunk: 2

Company: SUPERNUS PHARMACEUTICALS, INC.
Filing Date: 2025-07-28
Form: SC TO-T/A
Chunk 2
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 contained in the Offer to Purchase, are hereby amended and supplemented by adding a new paragraph at the end of Section 15-"Conditions of the Offer"of the Offer to Purchase to read as follows:

"The Regulatory Condition has been satisfied by the expiration of the HSR Act waiting period, effective July 25, 2025 at 11:59p.m. Eastern Time."

The Offer to Purchase and Items 4 and 11 of the Schedule TO, to the extent such Items incorporate by reference the information contained in the Offer to Purchase, are hereby amended and supplemented by adding a new paragraph at the end of Section 16 -"Certain Legal Matters; Regulatory Approvals - Antitrust Compliance"of the Offer to Purchase to read as follows:

"The waiting period applicable to the Offer under the HSR Act expired effective July 25, 2025 at 11:59 p.m. Eastern Time. Accordingly, the Regulatory Condition has been satisfied. The Offer continues to be subject to the remaining conditions set forth in Section 15 -"Conditions of the Offer"of the Offer to Purchase."

Item 12.

Item 12 of the Schedule TO is
hereby amended and supplemented by adding the following exhibit thereto:

Index No.

| (a)(5)(C) | Press                                                              
 Release issued by Supernus Pharmaceuticals, Inc. on July 28, 2025. |

<div align='center'>SIGNATURES</div>

After due inquiry and to the best of my knowledge
and belief, I certify that the information set forth in this statement is true, complete and correct.

| Dated: July 28, 
 2025            |                         |
|:----------------|:------------------------|
| Saphire Inc.    |                         |
| By:             | /s/ Jack A. Khattar     |
| Name:           | Jack A. Khattar         |
| Title:          | President and Treasurer |

| Supernus Pharmaceuticals, Inc. |                                 |
| By:                            | /s/ Timothy C. Dec              |
| Name:                          | Timothy C. Dec                  |
| Title:                         | Senior Vice President and Chief 
 Financial Officer               |