Company: NCNA
Filing Date: 2025-04-24
Form Type: F-1
Source: 0001193125-25-092131
Chunk: 65

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-1
Chunk 65
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 it acts in good faith and in accordance with the terms of the deposit agreement. |

46

| • |     | The depositary disclaims any liability for any failure to accurately determine the lawfulness or practicality of                                                                                                                                        
 any action, for the content of any document forwarded to you on our behalf or for the accuracy of any translation of such a document, for the investment risks associated with investing in ordinary shares, for the validity or worth of the ordinary  
 shares, for any tax consequences that result from the ownership of ADSs or other deposited property, for the credit-worthiness of any third party, for allowing any rights to lapse under the terms of the deposit agreement, for the timeliness of any 
 of our notices or for our failure to give notice or for any act or omission of or information provided by DTC or any DTC participant.                                                                                                                   |

| • |     | The depositary shall not be liable for acts or omissions of any successor depositary in connection with any 
 matter arising wholly after the resignation or removal of the depositary.                                   |

| • |     | We and the depositary will not be obligated to perform any act that is inconsistent with the terms of the deposit 
 agreement.                                                                                                        |

| • |     | We and the depositary disclaim any liability if we or the depositary are prevented or forbidden from or subject                                                                                                                                           
 to any civil or criminal penalty or restraint on account of, or delayed in, doing or performing any act or thing required by the terms of the deposit agreement, by reason of any provision, present or future of any law or regulation, including        
 regulations of any stock exchange or by reason of present or future provisions of our Articles of Association, or any provision of or governing the securities on deposit, or by reason of any act of God or war or other circumstances beyond our or the 
 depositary’s control.                                                                                                                                                                                                                                     |

| • |     | We and the depositary disclaim any liability by reason of any exercise of, or failure to exercise, any discretion                       
 provided for in the deposit agreement or in our Articles of Association or in any provisions of or governing the securities on deposit. |

| • |     | We and the depositary further disclaim any liability for any action or inaction in reliance on the advice or                                                                                                                                          
 information received from legal counsel, accountants, any person presenting ordinary shares for deposit, any holder of ADSs or authorized representatives thereof, or any other person believed by either of us in good faith to be competent