Company: EDSA
Filing Date: 2025-05-28
Form Type: S-8
Source: 0001171843-25-003499
Chunk: 0

Company: Edesa Biotech, Inc.
Filing Date: 2025-05-28
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on May 28, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT

UNDER THE SECURITIES ACT OF 1933</div>

| EDESA                                                  
 BIOTECH, INC.                                          |
| (Exact name of registrant as specified in its charter) |

| British Columbia, Canada                                       |     | N/A                                 |
| (State or other jurisdiction of incorporation or organization) |     | -I.R.S. Employer Identification No. |
| 100 Spy Court                                                  
 Markham, Ontario, Canada                                       |     | L3R 5H6                             |
| (Address of principal executive offices)                       |     | -Zip Code                           |

<div align='center'>Edesa Biotech, Inc. 2019 Equity Incentive Compensation Plan

(Full title of the plan)

Peter Weiler

Chief Financial Officer

c/o Edesa Biotech, Inc.

100 Spy Court

Markham, Ontario, Canada L3R 5H6

(Name and address of agent for service)

(289) 800-9600

(Telephone number, including area code, of agent for
service)

Copies to:

Steven M. Skolnick, Esq.

Michael J. Lerner, Esq.

Lowenstein Sandler LLP

1251 Avenue of the Americas

New York, New York 10020

Telephone: (212) 262-6700</div>

Indicate by check mark whether the registrant is a
large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See
the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and
“emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer | ☐ | Smaller reporting company | ☒ |
| Non-accelerated filer   | ☒ | Accelerated filer         | ☐ |
|                         |   | Emerging growth company   | ☐ |

If an emerging growth company, indicate by check mark
if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting