Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 2

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 2
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 98.959 | % |     | $     | 2,379,718,500 |

______________

(1) Plus accrued interest from July 2, 2025, if settlement occurs after that date.

(2) For additional underwriting compensation information, see “Underwriting.”

Neither the SEC nor any other regulatory body has approved or disapproved of the Notes or passed upon the accuracy or adequacy of this prospectus supplement or the accompanying prospectus. Any representation to the contrary is a criminal offense.

The Notes offered by this prospectus supplement and the accompanying prospectus are being offered by the underwriters, subject to prior sale, withdrawal, cancellation or modification of the offer without notice, to delivery to and acceptance by the underwriters and to certain further conditions. It is expected that the Notes will be delivered in book-entry form only, on or about July 2, 2025, through the facilities of DTC and its participants, including Euroclear and Clearstream.

<div align='center'>Joint Lead Managers and Joint Bookrunners</div>

| J.P. Morgan |     | SMBC NIKKO |

| BNP PARIBAS |     | BofA Securities |     | HSBC |     | Morgan Stanley |

<div align='center'>Co-Managers</div>

| Barclays |     | Citigroup |     | COMMERZBANK |     | Goldman Sachs & Co. LLC |

| Mizuho Securities |     | Wells Fargo Securities |

<div align='center'>Prospectus Supplement dated June 26, 2025.</div>

### TABLE OF CONTENTS

#### Prospectus Supplement
|                                                           |     | Page  |
| ABOUT THIS PROSPECTUS SUPPLEMENT                          |     | S-iii |
| CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS |     | S-iv  |
| PRESENTATION OF FINANCIAL AND OTHER INFORMATION           |     | S-v   |
| PROSPECTUS SUPPLEMENT SUMMARY                             |     | S-1   |
| SUMMARY RISK FACTORS                                      |     | S-2   |
| THE OFFERING                                              |     | S-4   |
| RISK FACTORS                                              |     | S-7   |
| USE OF PROCEEDS                                           |     | S-10  |
| CAPITALIZATION AND INDEBTEDNESS                           |     | S-11  |
| SELECTED FINANCIAL AND OTHER INFORMATION                  |     | S-12  |
| DESCRIPTION OF