Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 18

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 18
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 of the underwriters in this offering, is our affiliate. The distribution arrangements for this offering comply with the requirements of Financial Industry Regulatory Authority, Inc. (“FINRA”) Rule 5121,  
 regarding a FINRA member firm’s participation in the distribution of securities of an affiliate. In accordance with Rule 5121, no FINRA member firm that has a conflict of interest under Rule 5121 may make sales in this offering to any 
 discretionary account without the prior approval of the customer.                                                                                                                                                                          |

| Registrar | Computershare Trust Company, N.A. |

| Depositary | Computershare Inc. and Computershare Trust Company, N.A., acting jointly. |

S-8

| Calculation Agent | Unless we have validly called all shares of the Series B Preferred Stock for redemption on the First Reset Date, we will appoint a calculation agent for the Series B Preferred Stock prior to the reset determination date related to the First 
 Reset Date. We may appoint ourselves or an affiliate of ours as calculation agent.                                                                                                                                                               |

S-9

SUMMARY CONSOLIDATED FINANCIAL AND OTHER INFORMATION The following table presents summary consolidated financial and other information as of and for the periods presented. The summary financial information as of December 31, 2024 and 2023, and for each of the years in the three-year period ended December 31, 2024, are derived from our audited consolidated financial statements and related notes, which are incorporated by reference into this prospectus supplement and the accompanying prospectus. The summary financial information for prior years is derived from our audited consolidated financial statements which are not incorporated by reference into this prospectus supplement and accompanying prospectus. The summary financial information as of June 30, 2025, and for the six-monthperiods ended June 30, 2025 and 2024, are derived from our unaudited consolidated financial statements and related notes, which are incorporated by reference into this prospectus supplement and the accompanying prospectus. Such unaudited financial statements have been prepared on the same basis as our annual consolidated financial statements and include all adjustments, consisting of only normal recurring adjustments, necessary for the fair presentation of the data in all material respects. The results for any interim period are not necessarily indicative of the results of operations to be expected for a full fiscal year.

|                                              |     | 2025         |  As of or for the six 
 months ended June 30, |     | 2024 |        |     | 202