Company: APXIF
Filing Date: 2025-06-13
Form Type: F-4/A
Source: 0001213900-25-054324
Chunk: 367

Company: APx Acquisition Corp. I
Filing Date: 2025-06-13
Form: F-4/A
Chunk 367
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 positive impact, and the results showed it works consistently well. The pilot test, which was sponsored by Heritas Argentina and CIBIC, was carried out in an Argentinian population between October 2022 and March 2024. A total of 634 individuals participated, and their gut microbiomes were respectively analyzed. The results revealed key patterns. For example: 52.84% of the participants had lower gut microbiome diversity than the average levels in our reference database, which can impact overall health (p<0.001). Additionally, 65.88% of participants produced fewer short -chainfatty acids, essential compounds that support metabolism and overall well -being, compared to typical levels in our reference database (p<0.001). We also found that participants had lower levels of gut bacteria diversity and balance, as well as a reduced ability to produce not only short -chainfatty acids but also essential nutrients like vitamins B1 (p=0.008), B7 (p=0.043), B9 (p=0.001), B12 (p=0.001). Additionally, levels of lipopolysaccharides (p=0.015), which play a role in immune function, were lower compared to the healthy reference group in our database. These differences were clear, consistent, and statistically significant. Based on these findings, we provided personalized nutrition recommendations to help participants improve their health datapoints. For example, when someone had less diverse gut bacteria and lower short -chainfatty acids production, we suggested a tailored diet. This included adding more fermented foods (like yogurt), seeds, and whole -graincereals. These foods contain prebiotic fiber and arabinoxylans — nutrients that nourish the gut bacteria responsible for producing short -chainfatty acids. Short -chainfatty acids help reduce inflammation and strengthen the immune system, leading to better overall health. For the construction of gut microbiome references databases in other countries or regions, participant selection, sample collection, and analysis are being conducted following the same methodology used for the Argentinian database. In Mexico, we have collected 80 biological samples to date from Mexico City. The collection was carried out in coordination with a local laboratory, to which we provided payment for the sample collection. In each new country where we plan to launch Rewell, the same sample collection process will be carried out in conjunction with local entities as we do not rely on existing reference datasets. Personal DNA and Gut Microbiome Profiling