Company: TEM
Filing Date: 2025-03-07
Form Type: 424B3
Source: 0001193125-25-049935
Chunk: 1

Company: Tempus AI, Inc.
Filing Date: 2025-03-07
Form: 424B3
Chunk 1
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 described in the section titled “ Risk Factors” beginning on page 5 of this prospectus, and under similar headings in any amendments or supplements to this prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities, or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.

The date of this prospectus is March 7, 2025.

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS                                                      |     |  ii |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS                       |     | iii |
| PROSPECTUS SUMMARY                                                         |     |   1 |
| RISK FACTORS                                                               |     |   5 |
| USE OF PROCEEDS                                                            |     |   6 |
| MANAGEMENT                                                                 |     |   7 |
| EXECUTIVE COMPENSATION                                                     |     |  16 |
| CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS                       |     |  30 |
| PRINCIPAL STOCKHOLDERS                                                     |     |  34 |
| SELLING STOCKHOLDER                                                        |     |  37 |
| CERTAIN MATERIAL U.S. FEDERAL INCOME TAX CONSEQUENCES FOR NON-U.S. HOLDERS |     |  39 |
| PLAN OF DISTRIBUTION                                                       |     |  43 |
| LEGAL MATTERS                                                              |     |  45 |
| EXPERTS                                                                    |     |  45 |
| WHERE YOU CAN FIND MORE INFORMATION                                        |     |  46 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE                          |     |  47 |

You should rely only on the information contained in this prospectus. No one has been authorized to provide you with information that is different from that contained in this prospectus. This prospectus is dated as of the date set forth on the cover hereof. You should not assume that the information contained in this prospectus is accurate as of any date other than that date. i

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement on Form S-1 that we filed with the
Securities and Exchange Commission, or the SEC, using the “shelf” registration process. Under this shelf registration process, the selling stockholder may, from time to time (after the expiration of any applicable lock-up period described herein), sell the Shares offered by them described in this prospectus. We