Company: CNTB
Filing Date: 2025-09-10
Form Type: POS AM
Source: 0001193125-25-200186
Chunk: 21

Company: Connect Biopharma Holdings Ltd
Filing Date: 2025-09-10
Form: POS AM
Chunk 21
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 to holdings in our Ordinary Shares.                                                                     |

| • |     | Investors may face difficulties in protecting the interests of investors, and the ability to protect the      
 rights of investors through U.S. courts may be limited, because we are incorporated under Cayman Islands law. |

| • |     | We may experience material weaknesses in our internal control over financial reporting in the future. If so,                                                                                                                                       
 or if we otherwise fail to maintain proper and effective internal control over financial reporting, our ability to produce accurate and timely consolidated financial statements could be impaired, investors may lose confidence in our financial 
 reporting and the trading price of our Ordinary Shares may decline.                                                                                                                                                                                |

| • |     | Our amended and restated memorandum and articles of association contain anti-takeover provisions that could                             
 discourage a third party from acquiring us, which could limit our shareholders’ opportunity to sell their Ordinary Shares at a premium. |

| • |     | We could be subject to securities class action litigation. |

| • |     | If securities or industry analysts do not continue to publish research or publish inaccurate or unfavorable 
 research about our business, the market price for our Ordinary Shares and trading volume could decline.     |

| • |     | The increasing use of social media platforms presents new risks and challenges. |

13

RISK FACTORS

Investment in any securities offered pursuant to this prospectus and the applicable prospectus supplement involves risks.
Before deciding whether to invest in our securities, you should carefully consider the risk factors incorporated by reference to our most recent Annual Report on Form 10-K and any subsequent Quarterly Reports
on Form 10-Q or Current Reports on Form 8-K, and all other information contained or incorporated by reference into this prospectus, as updated by our subsequent filings
under the Exchange Act, and the risk factors and other information contained in the applicable prospectus supplement and any applicable free writing prospectus. The occurrence of any of these risks might cause you to lose all or part of your
investment in the offered securities. There may be other unknown or unpredictable economic, business, competitive, regulatory or other factors that could have material adverse effects on our future results. Past financial performance may not be a
reliable indicator of future performance, and historical trends should not be used to anticipate results or trends in future periods. If any of these risks actually occurs, our business, financial condition, results of operations or cash flow could
be seriously harmed. This could cause the trading price of our securities to decline, resulting in a loss of