Company: PSTV
Filing Date: 2025-05-01
Form Type: DEFA14A
Source: 0000950170-25-061484
Chunk: 0

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-05-01
Form: DEFA14A
Chunk 0
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant x Filed by a party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ¨ Definitive Proxy Statement x Definitive Additional Materials ¨ Soliciting Material Pursuant to §240.14a-12

PLUS THERAPEUTICS, INC.

(Name of Registrant as Specified In Its Charter) (Name of Person(s) Filing Proxy Statement, if other than the Registrant) Payment of Filing Fee (Check all boxes that apply): x No fee required. ¨ Fee paid previously with preliminary materials. ¨ Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

<div align='center'>YOUR VOTE IS VERY IMPORTANT!
PLEASE VOTE TODAY</div>

May 1, 2025

Dear Stockholder,

We are contacting you to stress the importance of voting your shares in connection with Plus Therapeutics, Inc’s special meeting of stockholders, to be held completely virtually on May 2, 2025, commencing at 9:00 a.m. Eastern Time (the “Special Meeting”). We would like to remind you to vote your shares. Your vote is very important!

Stockholders are being asked to vote on the following important proposals:

Proposal 1 : To grant discretionary authority to our Board of Directors to (i) amend our Certificate of Incorporation, as amended (the “Certificate of Incorporation”) to combine outstanding shares of our common stock, par value $0.001 per share (the “Common Stock”), into a lesser number of outstanding shares, or a “reverse stock split,” at a specific ratio within a range of one-for-twenty five (1-for-25) to a maximum of a one-for-two hundred fifty (1-for-250), with the exact ratio to be determined by our Board in its sole discretion; and (ii) effect the reverse stock split, if at all, within twelve (12) months of the date the proposal is approved by stockholders (the “Reverse Stock Split Proposal”).

Proposal 2 : To authorize, for