Company: HCWB
Filing Date: 2025-04-16
Form Type: 424B3
Source: 0001193125-25-082835
Chunk: 87

Company: HCW Biologics Inc.
Filing Date: 2025-04-16
Form: 424B3
Chunk 87
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. Giles Living Trust. |

57

SELLING STOCKHOLDERS The securities offered under this prospectus may be offered from time to time by the selling stockholder named below or by any of their respective pledgees, donees, transferees or other successors-in-interest.As used in this prospectus, the term “selling stockholder” includes the selling stockholder identified below and any donees, pledgees, transferees or other successors-in-interestselling shares received after the date of this prospectus from the selling stockholder as a gift, pledge or other non-salerelated transfer. The selling stockholder named below acquired the shares of our Common Stock being offered under this prospectus directly from us. We issued the securities to the selling stockholder in reliance on an exemption from the registration requirements of the Securities Act pursuant to Section 4(a)(2) of the Securities Act and Rule 506 promulgated thereunder. The following table sets forth as of April 2, 2025:(1) the name of the selling stockholder for whom we are registering shares of our Common Stock under the registration statement of which this prospectus is a part, (2) the number of shares of our Common Stock beneficially owned by the selling stockholder prior to the offering, determined in accordance with Rule 13d-3under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), (3) the number of shares of our Common Stock that may be offered by the selling stockholder under this prospectus and (4) the number of shares of our Common Stock to be owned by the selling stockholder after completion of this offering. We will not receive any of the proceeds from the sale of the shares of our Common Stock offered under this prospectus. The amounts and information set forth below are based upon information provided to us by the selling stockholder or its representatives, or on our records, as of April 2, 2025. The percentage of beneficial ownership for the following table is based on 44,934,120 shares of our Common Stock outstanding as of April 2, 2025.

| Name of Selling                                     
 Stockholder                                         |        | Shares of Common Stock      
 Beneficially Owned Prior to 
 the Offering                |           |     |    |   |            |     |       |   |                  |     |             |     |    |   |        | Shares of Common Stock         
 Beneficially Owned After       
 Completion of the Offering (1) |