Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 416

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 416
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 the purchase, ownership and disposition of our Common Stock. In addition, this discussion does not address all aspects of U.S. federal income tax consequences to particular holders nor does it take into account the individual facts and circumstances of any particular holder that may affect the U.S. federal income tax consequences to such holder, and accordingly, is not intended to be, and should not be construed as, tax advice. This discussion does not address the U.S. federal 3.8% Medicare tax imposed on certain net investment income or any aspects of U.S. federal taxation other than those pertaining to the income tax (such as the gift or estate tax), nor does it address any tax consequences arising under any U.S. state and local, or non-U.S. taxlaws. Holders should consult their own tax advisors regarding such tax consequences in light of their particular circumstances. No ruling has been requested or will be obtained from the IRS with respect to the U.S. federal income tax consequences to a holder of the purchase, ownership or disposition of our Common Stock; thus, there can be no assurance that the IRS will not challenge the U.S. federal income tax treatment described below or that, if challenged, such treatment will be sustained by a court. This summary is limited to considerations relevant to holders that hold our Common Stock as “capital assets” within the meaning of Section 1221 of the Code (generally, property held for investment). This discussion does not address all aspects of U.S. federal income taxation that may be important to holders in light of their individual circumstances, including holders subject to special treatment under the U.S. tax laws, such as, for example:

| • |     | banks or other financial institutions, underwriters, or insurance companies; |

| • |     | dealers or traders in securities who elect to apply a mark-to-market method of accounting; |

| • |     | real estate investment trusts and regulated investment companies; |

| • |     | tax-exempt organizations, qualified retirement plans, individual 
 retirement accounts, or other tax-deferred accounts;             |

| • |     | expatriates or former long-term residents of the United States; |

| • |     | subchapter S corporations, partnerships or other pass-through entities or investors or beneficial owners in 
 such entities;                                                                                              |

| • |     | dealers or traders in securities, commodities or currencies; |

| • |     | grantor trusts; |

| • |     | persons subject to the alternative minimum tax; |

| •