Company: TAK
Filing Date: 2025-06-26
Form Type: 424B5
Source: 0001395064-25-000101
Chunk: 9

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-26
Form: 424B5
Chunk 9
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 of patent or regulatory data or marketing protection over our products or patent infringement by generic or biosimilar manufacturers;

◦ Difficulty maintaining the competitiveness of our products;

◦ Our use of third parties for the performance of certain key business functions and the inputs for our products, as well as changes in the costs of such inputs (including as a result of tariffs);

◦ The technically complex and highly regulated nature of the manufacture of our products; and

◦ The illegal distribution and sale by third parties of counterfeit versions of our products or products stolen from us;

• Risks relating to our business strategies, such as:

◦ Our substantial debt;

◦ Risks from the pursuit of acquisitions;

◦ Risks relating to our restructuring initiatives;

◦ Risks relating to the global nature of our operations;

◦ Risks relating to corporate sustainability-related measures, or complying with emerging sustainability-related requirements and expectations;

◦ Risks relating to our digital transformation initiatives;

◦ Risks relating to our information technology systems and our systems and infrastructure; and

◦ Risks relating to attracting and retaining personnel;

• Legal and regulatory risks, such as:

◦ Litigation risks;

◦ Product liability claims;

◦ Intellectual property infringement claims directed at us by third parties;

◦ Evolving and complex tax and related risks;

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◦ Changes in data privacy and protection laws and regulations or failure to comply with such laws and regulations; and

◦ Claims relating to our use, manufacture, handling, storage or disposal of hazardous materials;

• Risks relating to the operating environment, such as:

◦ Foreign currency exchange rate fluctuations;

◦ Climate change, extreme weather events, earthquakes, civil or political unrest, terrorism or other catastrophic events; and

◦ Risks relating to social media platforms and new technologies;

• Other risks affecting our business, such as:

◦ Sales to wholesalers are concentrated, which exposes us to credit risks and pricing pressures; and

◦ We may have to recognize additional charges on our statements of profit or loss due to impairment of goodwill, other intangible assets and equity method investments;

• Risks relating to the Notes, such as:

◦ The unsecured nature and structural subordination of the Notes;

◦ The TUSFI Indenture and the Notes contain only very limited restrictions on our ability to pledge, dispose or securitize our assets, pay dividends, incur indebtedness or issue or repurchase securities and provide holders with limited