Company: CERO
Filing Date: 2025-12-02
Form Type: 424B3
Source: 0001213900-25-117352
Chunk: 5

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-12-02
Form: 424B3
Chunk 5
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 registration rights agreement with the Investor (the “Registration Rights Agreement”),
pursuant to which the Company agreed to provide the Investor with customary registration rights related to the shares issued under the
Registration Rights Agreement.

The foregoing descriptions of the Purchase Agreement
and the Registration Rights Agreement do not purport to be complete and are qualified in their entirety by reference to the Purchase Agreement
and the Registration Rights Agreement, copies of which are filed as Exhibits 10.1 and 10.2 hereto and incorporated by reference herein.

Item 9.01. Financial Statements and Exhibits.

(d) Exhibits.

| Exhibit No. 
 10.1*       
 10.2*       |     | Description                                                                                                                                    
 Common Stock Purchase Agreement, by and between CERo Therapeutics Holdings, Inc., and an institutional investor, dated as of November 26, 2025 
 Registration Rights Agreement, by and between CERo Therapeutics Holdings, Inc., and an institutional investor, dated as of November 26, 2025.  |
|:------------|:----|:-----------------------------------------------------------------------------------------------------------------------------------------------|
| 104         |     | Cover Page Interactive Data File (embedded within the Inline XBRL document).                                                                   |

| * | Filed herewith. |

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SIGNATURE</div>

Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

| CERO THERAPEUTICS HOLDINGS, INC. |                         |
| By:                              | /s/ Chris Ehrlich       |
| Name:                            | Chris Ehrlich           |
| Title:                           | Chief Executive Officer |

Dated: December 2, 2025

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