Company: SPRB
Filing Date: 2025-10-29
Form Type: S-3
Source: 0001193125-25-256668
Chunk: 11

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-10-29
Form: S-3
Chunk 11
---
 in, and are not considered part of, this prospectus.

<div align='center'>4</div>

THE OFFERING

| Common Stock Offered by the Selling Stockholders | 735,325 Shares (consisting of 502,181 outstanding shares of our common stock and 233,144 shares of our common stock issuable upon the exercise of the Pre-Funded Warrants).                                                                                                                                                                                     |
| Use of Proceeds                                  | The selling stockholders will receive all of the proceeds from the sale of the Shares hereunder. Accordingly, we will not receive any of the proceeds from the sale of the Shares in this offering; however, we will receive proceeds from any cash exercise of the Pre-Funded Warrants. See “Use of Proceeds.”                                                 |
| Risk Factors                                     | An investment in our common stock involves a high degree of risk. See the information contained in or incorporated by reference in the section titled “Risk Factors” and under similar headings in the other documents that are incorporated by reference herein, as well as the other information included in or incorporated by reference in this prospectus. |
| Nasdaq Capital Market Symbol                     | Our common stock is listed on The Nasdaq Capital Market under the symbol “SPRB.”                                                                                                                                                                                                                                                                                |

5

<div align='center'>RISK FACTORS</div>

Investing in our securities involves a high degree of risk. You should carefully review the risks and uncertainties described under the heading “Risk Factors” contained in our Annual Report on Form 10-K for the fiscal year ended December 31, 2024, as updated by our quarterly and other reports and documents that are incorporated by reference into this prospectus, before deciding whether to purchase any of the securities being registered pursuant to the registration statement of which this prospectus is a part. Each of the risk factors could adversely affect our business, operating results and financial condition, as well as adversely affect the value of an investment in our securities, and the occurrence of any of these risks might cause you to lose all or part of your investment. Additional risks not presently known to us or that we currently believe are immaterial may also significantly impair our business operations. Please also read carefully the section below titled “Special Note Regarding Forward-Looking Statements.”

<div align='center'>6</div>

SELECTED FINANCIAL DATA REFLECTING REVERSE STOCK SPLIT Reverse Stock Split On July 23, 2025, we completed a one-for-seventy-five (1:75) reverse stock split of our outstanding common stock