Company: FITBI
Filing Date: 2025-10-06
Form Type: 425
Source: 0001193125-25-230874
Chunk: 1

Company: FIFTH THIRD BANCORP
Filing Date: 2025-10-06
Form: 425
Chunk 1
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 NASDAQ Stock Market LLC |
| Depositary Shares Representing a 1/40th Ownership Interest in a Share of 6.00% Non-Cumulative Perpetual Class B Preferred Stock, Series A |     | FITBP     |     | The NASDAQ Stock Market LLC |
| Depositary Shares Representing a 1/1000th Ownership Interest in a Share of 4.95% Non-Cumulative Perpetual Preferred Stock, Series K       |     | FITBO     |     | The NASDAQ Stock Market LLC |

Indicate by check mark whether the registrant is an emerging growth company as defined in as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2of the Securities Exchange Act of 1934 (§240.12b-2of this chapter). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

| Item 7.01 | Regulation FD Disclosure. |

On October 6, 2025, Fifth Third Bancorp and Comerica Incorporated issued a joint press release announcing the execution of a definitive merger agreement pursuant to which, on the terms and subject to the conditions set forth therein, Comerica Incorporated will merge with Fifth Third Financial Corporation, a wholly-owned subsidiary of Fifth Third Bancorp, with Fifth Third Financial Corporation as the surviving corporation in the merger. A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-Kand is incorporated herein by reference. In addition, Fifth Third Bancorp intends to provide supplemental information regarding the proposed transaction in connection with presentations to analysts and investors. A copy of the investor presentation is attached as Exhibit 99.2 to this Current Report on Form 8-Kand is incorporated herein by reference. The information in this Form 8-Kand Exhibits attached hereto shall not be deemed filed for purposes of Section 18 of the Securities Exchange Act of 1934, nor shall they be deemed incorporated by reference in any filing under the Securities Exchange Act of 1934 or the Securities Act of 1933, except as shall be expressly set forth by specific reference. FORWARD-LOOKING STATEMENTS This Current Report on Form 8-K contains statements that constitute “forward-looking statements”