Company: CERO
Filing Date: 2025-08-22
Form Type: 424B3
Source: 0001213900-25-080011
Chunk: 103

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-08-22
Form: 424B3
Chunk 103
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 2002 |
| 32.1**   |     | Certification of Principal Executive Officer Pursuant to 18 U.S.C. Section 1350, as adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                 |
| 32.2**   |     | Certification of Principal Financial Officer Pursuant to 18 U.S.C. Section 1350, as adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002                 |
| 101.INS* |     | Inline                                                                                                                                                                
 XBRL Instance Document                                                                                                                                                |
| 101.SCH* |     | Inline                                                                                                                                                                
 XBRL Taxonomy Extension Schema Document                                                                                                                               |
| 101.CAL* |     | Inline                                                                                                                                                                
 XBRL Taxonomy Extension Calculation Linkbase Document                                                                                                                 |
| 101.DEF* |     | Inline                                                                                                                                                                
 XBRL Taxonomy Extension Definition Linkbase Document                                                                                                                  |
| 101.LAB* |     | Inline                                                                                                                                                                
 XBRL Taxonomy Extension Labels Linkbase Document                                                                                                                      |
| 101.PRE* |     | Inline                                                                                                                                                                
 XBRL Taxonomy Extension Presentation Linkbase Document                                                                                                                |
| 104      |     | Cover                                                                                                                                                                 
 Page Interactive Data File-the cover page interactive data is embedded within the Inline XBRL document or included within the Exhibit                                 
 101 attachments.                                                                                                                                                      |

| * | Filed     
 herewith. |

| ** | Furnished 
 herewith. |

| + | Schedules                                                                                  
 and exhibits have been omitted pursuant to Item 601(a)(5) of Regulation S-K. A copy of any 
 omitted schedule and/or exhibit will be furnished to the SEC upon request.                 |

| † | Certain                                                                                        
 portions of this document that constitute confidential information have been redacted pursuant 
 to Item 601(b)(10) of Regulation S-K.                                                          |

| ^ | Indicates management contract or compensatory plan or arrangement. |

<div align='center'>47

SIGNATURES</div>

In accordance with the requirements of the Exchange Act, the registrant caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

| Date: August 22, 2025 | CERO THERAPEUTICS 
 HOLDINGS, INC.    
 By:               | /s/                                  
 Chris Ehrlich                        |
|:----------------------|:------------------|:-------------------------------------|
|                       | Name:             | Chris Ehrlich