Company: RVRC
Filing Date: 2025-10-03
Form Type: S-1/A
Source: 0001213900-25-096094
Chunk: 9

Company: Revium Rx.
Filing Date: 2025-10-03
Form: S-1/A
Chunk 9
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-3 (Biosafety Level 3)” is
a classification for laboratories that handle pathogens which can cause serious or potentially lethal disease through inhalation.

“BALB/c mice” is one of the
most widely used inbred strains of laboratory mice in biomedical research, particularly in immunology and cancer studies. An “inbred
strain” means that mice have been bred through more than 20 generations of brother-sister mating, resulting in a genetically homogeneous
population where every individual is virtually identical. This genetic uniformity makes BALB/c mice a predictable and reliable model
for scientific experiments.

“Drug-Resistant Neisseria gonorrhoeae”
is a common sexually transmitted infection caused by Neisseria gonorrhoeae, has become increasingly resistant to nearly all antibiotics
previously used to treat it. Certain strains now show resistance to extended-spectrum cephalosporins, the last remaining recommended treatment,
raising urgent public health concerns over the potential for untreatable infections.

“Excipients are inactive substances included
in drug formulations to aid in the manufacturing process, drug stability, or delivery, without exerting therapeutic effects.

“Extracellular Matrix (ECM) means a network
of proteins and polysaccharides outside cells that provides structural and biochemical support, especially important in tissue integrity
and tumor progression.

“HPCD Formulation (Hydroxypropyl-β-Cyclodextrin
Formulation) represents a formulation that uses hydroxypropyl-β-cyclodextrin (HPCD), a modified cyclodextrin molecule, to enhance
the solubility, stability, and bioavailability of poorly water-soluble drugs. HPCD encapsulates the active pharmaceutical ingredient within
its hydrophobic cavity, improving its dissolution and systemic absorption while minimizing irritation and toxicity. It is widely used
in injectable, oral, and topical drug delivery systems.

“Hydroxypropyl-Beta-Cyclodextrin (HPCD)
is a water-soluble derivative of cyclodextrin used to improve the solubility and stability of poorly water-soluble drugs.

“Isolates” are Specific strains of
microorganisms (such as bacteria or fungi) that have been cultured and identified, often used in susceptibility testing.

“MRSA (Methicillin-Resistant Staphylococcus aureus)”is a type of Staphylococcus aureus bacteria that has developed resistance to methicillin and related
antib