Company: ARTL
Filing Date: 2025-09-30
Form Type: 424B5
Source: 0001640334-25-001749
Chunk: 0

Company: ARTELO BIOSCIENCES, INC.
Filing Date: 2025-09-30
Form: 424B5
Chunk 0
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Filed Pursuant to Rule 424(b)(5)

Registration No. 333-273153

This preliminary prospectus supplement relates to an effective registration statement under the Securities Act of 1933, as amended, but the information in this preliminary prospectus supplement is not complete and may be changed. This preliminary prospectus supplement and the accompanying base prospectus are not an offer to sell and are not soliciting an offer to buy these securities in any jurisdiction where the offer or sale is not permitted.

<div align='center'>SUBJECT TO COMPLETION, DATED SEPTEMBER 30, 2025</div>

PRELIMINARY PROSPECTUS SUPPLEMENT

(to Prospectus dated July 14, 2023)

<div align='center'>[ ] Shares of Common Stock

Pre-Funded Warrants to Purchase up to [ ] Shares of Common Stock</div>

Pursuant to this prospectus supplement and the accompanying prospectus, Artelo Biosciences, Inc. (the “Company,” “Artelo,” “Artelo Biosciences,” “we,” “us,” and “our”) is offering up to [ ] shares of our common stock, par value $0.001 per share, at a price of $[ ] per share. We are also offering [ ] pre-funded warrants (each a “Pre-funded Warrant”) to purchase up to [ ] shares of our common stock, exercisable at an exercise price of $0.001 per share, to those purchasers whose purchase of shares of common stock in this offering would otherwise result in the purchaser, together with its affiliates and certain related parties, beneficially owning more than 4.99% (or, at the election of the holder, 9.99%) of our outstanding shares of common stock immediately following the consummation of this offering. The purchase price of each Pre-funded Warrant is $[ ], which equals the price per share of common stock being sold to the public in this offering, minus $0.001. The Pre-funded Warrants will be immediately exercisable upon issuance until exercised in full.

Our common stock is listed on The Nasdaq Capital Market tier of The Nasdaq Stock Market LLC (“Nasdaq”) under the symbol “ARTL.” On September 29, 2025, the last reported sale price for our common stock on the Nasdaq Capital Market was $5.85 per share. There is no established trading market for the Pre-funded Warrants, and we do not intend to apply for listing