Company: SCLXW
Filing Date: 2025-09-29
Form Type: 424B3
Source: 0001193125-25-221020
Chunk: 16

Company: Scilex Holding Co
Filing Date: 2025-09-29
Form: 424B3
Chunk 16
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ED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 23, 2025 SCILEX HOLDING COMPANY (Exact name of registrant as specified in its charter)

| Delaware                     |     | 001-39852   |     | 92-1062542         |
| (State or other jurisdiction 
 of incorporation)            |     | -Commission 
 File Number |     | -IRS Employer      
 Identification No. |

960 San Antonio Road, Palo Alto, California, 94303 (Address of principal executive offices, including zip code) (650) 516-4310 Registrant’s telephone number, including area code N/A (Former Name or Former Address, if Changed Since Last Report) Check the appropriate box below if the Form 8-Kfiling is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

| ☐ | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |

| ☐ | Soliciting material pursuant to Rule 14a-12 under the Exchange Act 
 (17 CFR 240.14a-12)                                                |

| ☐ | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |

| ☐ | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |

Securities registered pursuant to Section 12(b) of the Exchange Act:

| (Title of each class)                                                                |     | -Trading 
 Symbol   |     | -Name of exchange           
 on which registered         |
| Common Stock, par value $0.0001 per share                                            |     | SCLX     |     | The Nasdaq Stock Market LLC |
| Warrants to purchase one share of common stock, each at an exercise price of $402.50 |     | SCLXW    |     | The Nasdaq Stock Market LLC |

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2of