Company: PRME
Filing Date: 2025-04-22
Form Type: DEFA14A
Source: 0001628280-25-018706
Chunk: 0

Company: Prime Medicine, Inc.
Filing Date: 2025-04-22
Form: DEFA14A
Chunk 0
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy Statement ☒ Definitive Additional Materials ☐ Soliciting Material under §240.14a-12 PRIME MEDICINE, INC. (Name of Registrant as Specified in Its Charter) (Name of Person(s) Filing Proxy Statement if other than Registrant) Payment of Filing Fee (Check the appropriate box): ☒ No fee required. ☐ Fee paid previously with preliminary materials. ☐ Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

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# V70763-P28496 PRIME MEDICINE, INC. 60 FIRST STREET CAMBRIDGE, MA 02141 PRIME MEDICINE, INC. 2025 Annual Meeting Vote by June 3, 2025 11:59 PM ET You invested in PRIME MEDICINE, INC. and it’s time to vote! You have the right to vote on proposals being presented at the 2025 Annual Meeting. Important Notice Regarding the Availability of Proxy Materials for the 2025 Annual Meeting of Stockholders to be Held on June 4, 2025. Vote Virtually at the Meeting* June 4, 2025 2:00 PM ET Virtually at: www.virtualshareholdermeeting.com/PRME2025 Get informed before you vote View the Notice, Proxy Statement and 2024 Annual Report online at www.ProxyVote.com OR you can receive a free paper or email copy of the material(s) by requesting prior to May 21, 2025. If you would like to request a copy of the material(s) for this and/or future annual stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579