Company: RGNX
Filing Date: 2025-03-13
Form Type: POSASR
Source: 0001193125-25-053917
Chunk: 22

Company: REGENXBIO Inc.
Filing Date: 2025-03-13
Form: POSASR
Chunk 22
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 this option); |

13

| • |     | any provisions for convertibility or exchangeability of the debt securities into or for any other securities; |

| • |     | any listing of the debt securities on any securities exchange; |

| • |     | any paying agents, authenticating agents, security registrars or other agents for debt securities, if other than 
 the trustee;                                                                                                     |

| • |     | any provisions relating to any security provided for the debt securities, including any provisions regarding the 
 circumstances under which collateral may be released or substituted;                                             |

| • |     | if applicable, a discussion of certain U.S. federal income tax considerations, including those related to 
 original issue discount, if applicable; and                                                               |

| • |     | any other material terms. |

Unless the prospectus supplement states otherwise, principal, interest and premium, if any, will be paid by us in immediately available funds. General Any debt securities we issue will be governed by a document called an “indenture,” the form of which is filed as an exhibit to the registration statement of which this prospectus forms a part. An indenture is a contract between us and a financial institution acting as trustee on behalf of the holders of the debt securities, and is subject to and governed by the Trust Indenture Act of 1939. The trustee has two main roles. First, the trustee can enforce holders’ rights against us if we default. There are some limitations on the extent to which the trustee acts on holders’ behalf, described in the second paragraph under “Description of Debt Securities—Events of Default.” Second, the trustee performs certain administrative duties, such as sending interest and principal payments to holders. The indenture provides that any debt securities proposed to be sold under this prospectus and the applicable prospectus supplement, including any debt securities issuable upon conversion or exchange of other offered securities, which we refer to as underlying debt securities, may be issued under the indenture in one or more series. For purposes of this prospectus, any reference to the payment of principal of, or interest or premium, if any, on, debt securities will include additional amounts if required by the terms of the debt securities. The indenture also provides that there may be more than one trustee thereunder, each with respect to one or more different series of securities issued thereunder. In the event that there is more than one trustee under the indenture, the powers and trust obligations of each trustee described in this prospectus will extend only to the