Company: NCNA
Filing Date: 2025-06-27
Form Type: 424B5
Source: 0001193125-25-151464
Chunk: 6

Company: NuCana plc
Filing Date: 2025-06-27
Form: 424B5
Chunk 6
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 under our equity incentive plans as of 
 June 20, 2025 at a weighted average exercise price of £0.0013 per ordinary share and (ii) 1,487,027,625 ordinary shares underlying ADSs issuable upon exercise of outstanding Series A Warrants as of June 26, 2025.            |

| Ordinary shares to be outstanding immediately after this offering | 34,540,891,147 ordinary shares (including those ordinary shares represented by ADSs), assuming no Series A ADS Purchase Warrants, or Series A Warrants, are exercised. |

| Nasdaq Capital Market Symbol | “NCNA” |

S-5

RISK FACTORS

An investment in our ADSs involves a high degree of risk. Before deciding whether to invest in our ADSs, you should consider carefully the risks described below and discussed under the sections captioned “Risk Factors” contained in our most recent Annual Report on Form 20-F,which is incorporated by reference herein in their entirety, together with other information in this prospectus supplement, the information and documents incorporated by reference in this prospectus supplement, including, for the avoidance of doubt, any “Supplemental Risk Factors” filed with our Form 6-Ksfrom time to time, and in any free writing prospectus that we have authorized for use in connection with this offering. If any of these risks actually occurs, our business, financial condition, results of operations or cash flow could be seriously harmed. This could cause the trading price of our ADSs to decline, resulting in a loss of all or part of your investment.

Our business, financial condition or results of operations could be materially adversely affected by any of these risks. The trading price of our securities could decline due to any of these risks, and you may lose part or all of your investment. This prospectus supplement and the incorporated documents also contain forward-looking statements that involve risks and uncertainties. Our actual results could differ materially from those anticipated in these forward-looking statements as a result of certain factors, including the risks mentioned below. Forward-looking statements included in this prospectus supplement are based on information available to us on the date hereof, and all forward-looking statements in documents incorporated by reference are based on information available to us as of the date of such documents. We disclaim any intent to update any forward-looking statements.

Risks Related to This Offering

Our management will have broad discretion over the use of the net proceeds from this offering, and you may not agree with how we use the proceeds