Company: TEM
Filing Date: 2025-08-27
Form Type: 424B7
Source: 0001193125-25-189854
Chunk: 15

Company: Tempus AI, Inc.
Filing Date: 2025-08-27
Form: 424B7
Chunk 15
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 of securities for any loan or obligation (including obligations associated with derivative                                                                                                                                                 
 transactions), including pledges to brokers or dealers who may from time to time effect distributions of securities, and in the case of any collateral call or default on such loan or obligation, pledges or sales of securities by such pledgee or 
 secured parties;                                                                                                                                                                                                                                     |

| • |     | delayed delivery arrangements providing for payment and delivery on a specified date in the future; |

| • |     | in “at the market” offerings, as defined in Rule 415 under the Securities Act, at negotiated prices,                                                                                                                                                      
 at prices prevailing at the time of sale or at prices related to such prevailing market prices, including sales made directly on a national securities exchange or sales made through a market maker other than on an exchange or other similar offerings 
 through sales agents;                                                                                                                                                                                                                                     |

| • |     | in privately negotiated transactions; |

| • |     | through dividends or other distributions made by a selling stockholder to its partners, members or stockholders; |

| • |     | in options transactions; |

| • |     | through a combination of any of the above methods of sale; or |

| • |     | any other method permitted pursuant to applicable law. |

S-11

In addition, any securities that qualify for sale pursuant to Rule 144 or another exemption
from registration under the Securities Act or other such exemption may be sold under Rule 144 rather than pursuant to this prospectus supplement or the accompanying prospectus. Further, the selling stockholders may enter into derivative transactions
with broker-dealers, other financial institutions or third parties or sell securities not covered by this prospectus supplement or the accompanying prospectus to third parties in privately negotiated or registered transactions. These transactions
may involve the sale of shares of Class A common stock by the selling stockholders by forward sale or by an offering (directly or by entering into derivative transactions with broker-dealers, other financial institutions or third parties) of
options, swaps, rights, warrants or other securities that are offered with, convertible into or exchangeable for shares of Class A common stock.

The selling stockholders may elect to make an in-kind distribution of the shares of Class A
common stock to its members, partners or shareholders. In such event, we may file a prospectus supplement to the extent required by law in order to permit the distributees to use the prospectus to resell the shares of Class A common stock
acquired in the distribution.

To the extent required, this