Company: SCLXW
Filing Date: 2025-02-14
Form Type: PRE 14A
Source: 0001193125-25-027244
Chunk: 8

Company: Scilex Holding Co
Filing Date: 2025-02-14
Form: PRE 14A
Chunk 8
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 to direct your broker, bank or other nominee, as applicable, on how to vote your shares. Street name stockholders should generally be able to vote by returning a voting instruction form or on the Internet. However, the availability of Internet voting will depend on the voting process of your broker, bank or other nominee. As discussed above, if you are a street name stockholder, you must obtain a legal proxy from your broker, bank or other nominee in order to vote your shares by remote communication in the Special Meeting. Can I change my vote or revoke my proxy? Yes, if you are a stockholder of record, you can change your vote or revoke your proxy any time before the Special Meeting by:

| • |     | entering a new vote by Internet; |

| • |     | completing and returning a later-dated proxy card; |

| • |     | notifying our Corporate Secretary, in writing, at Scilex Holding Company, 960 San Antonio Road, Palo Alto, CA 
 94303; or                                                                                                     |

| • |     | attending and voting electronically at the Special Meeting (although attendance at the Special Meeting will 
 not, by itself, revoke a proxy).                                                                            |

If you are a street name stockholder, your broker, bank or other nominee can provide you with instructions on how to change your vote. Will my vote be kept confidential? Yes, your vote will be kept confidential and not disclosed to the Company unless:

| • |     | required by law; |

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| • |     | you expressly request disclosure on your proxy; or |

| • |     | there is a proxy contest. |

Why isn’t the Special Meeting being held in-person? In order to provide expanded access to our stockholders, our Board has determined to hold a live audio webcast in lieu of an in-personmeeting. The virtual-only approach also lowers costs and aligns with our broader sustainability goals. Although no physical in-personmeeting will be held, we designed the format of the Special Meeting to ensure that our stockholders of record who attend the Special Meeting will be afforded similar rights and opportunities to participate as they would at an in-personmeeting. You will be able to vote and submit your questions during the meeting at www.virtualshareholdermeeting.com/SCLX2025SM. What do I need to do to attend the Special Meeting online? We will be hosting the Special Meeting via live audio webcast only. If you are a stockholder as of the Record Date and wish to virtually attend the Special Meeting