Company: APM
Filing Date: 2025-12-05
Form Type: 424B5
Source: 0001213900-25-118752
Chunk: 295

Company: Aptorum Group Ltd
Filing Date: 2025-12-05
Form: 424B5
Chunk 295
---
 handled in the lab without 
 degradation concerns                                             |

Thus, miRNAs from the brain
can be interrogated using a routine blood sample.

Early, Specific Detection of MCI and AD

MCI and AD

Both the number of AD patients
and the number of people at risk for developing AD are growing rapidly, especially in the developed countries, in part due to increased
lifespan.

Early diagnosis and intervention
are keys to developing more effective treatment, or potentially prevention, of AD. Alzheimer’s Association Report: 2025 Alzheimer’s
Disease Facts and Figures (https://www.alz.org/media/documents/alzheimers-facts-and-figures.pdf) provides the following statistics:

| ● | An estimated 7.2 million Americans age 65 and older are                    
 living with Alzheimer’s in 2025. Seventy-four percent are age 75 or older. |

| ● | About 1 in 9 people age 65 and older (11%) has Alzheimer’s. |

| ● | Almost two-thirds of Americans with Alzheimer’s are 
 women.                                              |

| ● | Older Black Americans are about twice as likely to have Alzheimer’s 
 or other dementias as older Whites.                                 |

| ● | Older Hispanics are about one and one-half times as likely 
 to have Alzheimer’s or other dementias as older Whites.    |

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| ● | People younger than 65 can also develop Alzheimer’s                                                                             
 dementia. Although prevalence studies are limited, researchers believe about 110 of every 100,000 people age 30 to 64 years, or 
 about 200,000 Americans in total, have younger-onset dementia.                                                                  |

| ● | Someone in the US develops AD every 67 seconds and by 2050                           
 one new case of AD is expected to develop every 33 seconds (~1M new cases per year); |

| ● | Deaths due to Alzheimer’s disease between 2000 and 2019 
 have more than doubled, increasing 145%.                |

| ● | Among people aged 70, 61% of those with Alzheimer’s                                                   
 dementia are expected to die before age 80, compared with 30% of people without Alzheimer’s dementia. |

| ● | This results in a significant cost burden to families, and 
 payors such as Medicare and Medicaid:                      |

| ● | In 2025, total payments for all individuals with Alzheimer’s                                
 disease or other dementias are estimated at