Company: CYTK
Filing Date: 2025-02-27
Form Type: S-3ASR
Source: 0001193125-25-039426
Chunk: 36

Company: CYTOKINETICS INC
Filing Date: 2025-02-27
Form: S-3ASR
Chunk 36
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 selling
securityholders or otherwise, information about such selling securityholders, their beneficial ownership of our securities and their relationship with us will be set forth in a prospectus supplement.

25

PLAN OF DISTRIBUTION We or selling securityholders may sell the securities from time to time pursuant to underwritten public offerings, direct sales to the public, “at the market” offerings, negotiated transactions, block trades or a combination of these methods. We or selling securityholders may sell the securities to or through one or more underwriters or dealers, through agents, or directly (acting as principal or agent) to one or more purchasers. We or selling securityholders may distribute securities from time to time in one or more transactions:

| • |     | at a fixed price or prices, which may be changed; |

| • |     | at market prices prevailing at the time of sale; |

| • |     | at prices related to such prevailing market prices; or |

| • |     | at negotiated prices. |

A prospectus supplement or supplements (and any related free writing prospectus that we may authorize to be provided to you) will describe the terms of the offering of the securities, including, to the extent applicable:

| • |     | the name or names of the underwriters, dealers or agents, if any; |

| • |     | the name or names of the selling securityholders, if any; |

| • |     | the purchase price of the securities or other consideration therefor, and the proceeds, if any, we will receive 
 from the sale;                                                                                                  |

| • |     | any options to purchase additional shares or other options under which underwriters may purchase additional 
 securities from us or any selling securityholders;                                                          |

| • |     | any agency fees or underwriting discounts and other items constituting agents’ or underwriters’ 
 compensation;                                                                                   |

| • |     | any public offering price; |

| • |     | any discounts or concessions allowed or reallowed or paid to dealers; and |

| • |     | any securities exchange or market on which the securities may be listed. |

Only underwriters named in the prospectus supplement will be underwriters of the securities offered by the prospectus supplement. Dealers and agents participating in the distribution of the securities may be deemed to be underwriters, and compensation received by them on resale of the securities may be deemed to be underwriting discounts. If such dealers or agents were deemed to be underwriters, they may be subject to statutory liabilities under