Company: XXII
Filing Date: 2025-11-04
Form Type: 424B5
Source: 0001493152-25-020754
Chunk: 11

Company: 22nd Century Group, Inc.
Filing Date: 2025-11-04
Form: 424B5
Chunk 11
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 required as a condition to close this offering, the actual total public offering amount, commissions and net proceeds to us, if any, are not determinable at this time.

We currently intend to use any net proceeds from this offering for general corporate purposes, including potentially expanding existing businesses, acquiring businesses and investing in other business opportunities, for expansion and acceleration of the launch of our VLN® reduced nicotine content tobacco cigarettes in additional markets, research and development expenses, procurement and development of additional intellectual property rights and working capital.

Our management will have broad discretion in the allocation of the net proceeds of this offering for any purpose, and investors will be relying on the judgment of our management with regard to the use of these net proceeds.

| S-8 |

<div align='center'>Dilution</div>

If you invest
in our common stock, your interest will be diluted to the extent of the difference between the price per share you pay in this offering
and the net tangible book value per share of our common stock immediately after this offering.

Our historical
net tangible book value as of September 30, 2025, was $14.9 million, or $2.13 per share of common stock based on 6,987,290 shares of
common stock outstanding as of September 30, 2025. Historical net tangible book value per share is calculated by subtracting our total
liabilities from our total tangible assets, which is total assets less intangible assets, and dividing this amount by the number of shares
of common stock outstanding as of such date.

After giving
effect to the sale of $25,000,000 of our common stock at an assumed offering price of $1.55 per share, the last reported sale price
of our common stock on the Nasdaq Capital Market on November 3, 2025, and after deducting commissions and estimated offering
expenses payable by us, the adjusted net tangible book value of our common stock as of September 30, 2025 would have been
approximately $39.0 million or $1.69 per share. The change represents an immediate increase (decrease) in net tangible book value
per share of our common stock of $(0.44) per share to existing stockholders and an immediate dilution (accretion) of $(0.14) per
share to new investors in this offering.

The following
table illustrates this per share dilution.

| Assumed offering price per share                                                      |     |   |       |   |