Company: NCNA
Filing Date: 2025-05-02
Form Type: F-1/A
Source: 0001193125-25-110310
Chunk: 22

Company: NuCana plc
Filing Date: 2025-05-02
Form: F-1/A
Chunk 22
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arrants and Warrants, holders of Pre-Funded Warrants, Series A Warrants and Series B Warrants will have no rights with respect to the ADSs
underlying such Pre-Funded Warrants and Warrants. Upon exercise of the Pre-Funded Warrants, Series A Warrants and Series B Warrants, as applicable, the holders will be
entitled to exercise the rights of an ADS holder only as to matters for which the record date occurs after the exercise date.

The Pre-FundedWarrants, Series A Warrants and Series B Warrants are speculative in nature.

The Pre-Funded Warrants, Series A Warrants and Series B Warrants do not confer any rights of ADS ownership on their respective holders, such as voting rights or the right to receive dividends, but rather merely
represent the right to acquire ADSs at a fixed price.

Purchasers who purchase our securities in this offering pursuant to a securities purchase agreement may have rights not available to purchasers that purchase without the benefit of a securities purchase agreement.

In
addition to rights and remedies available to all purchasers in this offering under federal securities law and state law, the purchasers that enter into a securities purchase agreement will also be able to bring claims of

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breach of contract against us. The ability to pursue a claim for breach of contract provides those investors with the means to enforce the covenants uniquely available to them under the
securities purchase agreement including, but not limited to: (i) timely delivery of securities; (ii) agreement to not enter into any financings for 90 days from the date on which the aggregate trading volume of the ADSs (which aggregate
trading volume shall include pre-market, market and post-market trading volume) as reported by Bloomberg, LP on and subsequent to the date of the purchase agreement equals or exceeds 300% of the number of ADSs (including ADSs underlying Pre-Funded
Warrants) sold pursuant to the purchase agreement on the closing date of this offering (and if such date is not a Trading Day, the next Trading Day following such date), or the Liquidity Date, and certain variable rate transactions for 180 days from
the Liquidity Date; and (iii) indemnification for breach of contract.

The Series A Warrants and Series B Warrants may not have value.

The Series A Warrants being offered by us in this offering have an exercise price equal to 125% of the combined
public offering price, and expire on the five-year anniversary of the