Company: VERA
Filing Date: 2025-12-10
Form Type: 424B5
Source: 0001193125-25-314244
Chunk: 45

Company: Vera Therapeutics, Inc.
Filing Date: 2025-12-10
Form: 424B5
Chunk 45
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icept met its primary endpoint with statistically significant reductions in urine protein creatinine ratio, or UPCR, on atacicept 150 mg, and stable estimated glomerular filtration rate, or eGFR, was
observed for participants on atacicept, with clinically meaningful and statistically significant difference versus placebo. Participants treated with atacicept demonstrated reductions in galactose-deficient IgA1, or
Gd-IgA1, the autoantigen produced by B cells in patients with IgAN, and a reduction in hematuria. The improvements in Gd-IgA1, hematuria, UPCR and eGFR represent the
quartet of findings consistent with IgAN disease modification. The 72-week and 96-week open label extension results showed consistent, and sustained reductions in Gd-IgA1, hematuria, UPCR and continued eGFR stabilization. Additionally, atacicept’s safety profile was comparable to placebo. We advanced atacicept 150 mg in a pivotal Phase 3 clinical trial in IgAN in the
second quarter of 2023, and we expect to report topline results in the second quarter of 2025. The Phase 2 portion of the ORIGIN clinical trial has been completed. We believe that atacicept has pipeline in a molecule potential, with potential
application in multiple diseases. We will be testing atacicept in non-IgAN autoimmune kidney diseases including primary membranous nephropathy, or pMN, focal segmental glomerulosclerosis, or FSGS, and minimal change disease, or MCD, in the Phase 2
PIONEER clinical trial, initiating in 2025. It is estimated that there are approximately 35,000 patients in the United States with pMN, and an additional 35,000 U.S. patients combined with either FSGS or MCD. Additional potential future indications
include, but are not limited to, several rheumatologic diseases such as systemic lupus erythematosus, or SLE, and Sjogren’s disease, and hematologic diseases including idiopathic thrombocytopenic purpura, or ITP, and autoimmune hemolytic
anemia, or AIHA. We also hold worldwide, exclusive development and commercial rights to MAU868, a potentially first-in-class monoclonal antibody to treat reactivated BK
virus, or BKV, infections,