Company: IMRX
Filing Date: 2025-08-13
Form Type: S-3
Source: 0001104659-25-077655
Chunk: 40

Company: Immuneering Corp
Filing Date: 2025-08-13
Form: S-3
Chunk 40
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4, as amended, or the Exchange Act. See “Plan of Distribution” for additional information regarding the compensation to be paid to Piper Sandler.

INVESTING IN OUR SECURITIES INVOLVES RISKS. SEE THE “RISK FACTORS” ON PAGE S-6OF THIS PROSPECTUS SUPPLEMENT AND IN THE DOCUMENTS INCORPORATED BY REFERENCE IN THIS PROSPECTUS SUPPLEMENT CONCERNING FACTORS YOU SHOULD CONSIDER BEFORE INVESTING IN OUR CLASS A COMMON STOCK.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.**

#### Piper Sandler
<div align='center'>The date of this prospectus supplement is , 2025.</div>

TABLE OF CONTENTS

TABLE OF CONTENTS

| ​ | ABOUT THIS PROSPECTUS SUPPLEMENT                                | ​ | ​ | ​ | ​ | S-1  | ​ | ​ |
| ​ | WHERE YOU CAN FIND MORE INFORMATION; INCORPORATION BY REFERENCE | ​ | ​ | ​ | ​ | S-2  | ​ | ​ |
| ​ | PROSPECTUS SUPPLEMENT SUMMARY                                   | ​ | ​ | ​ | ​ | S-4  | ​ | ​ |
| ​ | THE OFFERING                                                    | ​ | ​ | ​ | ​ | S-5  | ​ | ​ |
| ​ | RISK FACTORS                                                    | ​ | ​ | ​ | ​ | S-6  | ​ | ​ |
| ​ | CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS            | ​ | ​ | ​ | ​ | S-8  | ​ | ​ |
| ​ | USE OF PROCEEDS                                                 | ​ | ​ | ​ | ​ | S-10 | ​ | ​ |
| ​ | DIVIDEND POLICY                                                 | ​ | ​ | ​ | ​ | S-11 | ​ | ​ |
| ​ | DILUTION                                                        | ​ | ​ | ​ | ​ | S-12 | ​ | ​ |
| ​ | PLAN OF DISTRIBUTION                                            | ​ | ​ | ​ | ​ | S-13 | ​ | ​ |
| ​ | LEGAL MATTERS                                                   | ​ | ​ | ​ | ​ | S-15 | ​ | ​ |
| ​ | EXPERTS                                                         | ​ | ​ | ​ | ​ | S-15 | ​