Company: BCDRF
Filing Date: 2025-10-31
Form Type: 424B5
Source: 0001193125-25-260533
Chunk: 73

Company: Banco Santander, S.A.
Filing Date: 2025-10-31
Form: 424B5
Chunk 73
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 CUSIP number for the
2030 Fixed Rate Notes is 05971KAR0 and the ISIN is US05971KAR05. The initial CUSIP number for the 2035 Fixed Rate Notes is 05971KAS8 and the ISIN is US05971KAS87.

It is expected that delivery of the Notes will be made against payment on or about November 6, 2025, which will be the fifth New York
business day following the date of pricing of the Notes (such settlement cycle being referred to as “T+5”). Trades in the secondary market generally are required to settle in one business day, unless the parties to any such trade
expressly agree otherwise. Accordingly, purchasers who wish to trade Notes prior to the business day preceding the settlement date will be required, by virtue of the fact that the Notes initially will settle in T+5, to specify an alternate
settlement cycle at the time of any such trade to prevent a failed settlement. Such purchasers should consult their own advisors.

No Sales of Similar Securities

From the date of this prospectus supplement, and continuing to and including November 6, 2025, we have agreed that we
will not, without the prior written consent of the Underwriters, offer, sell, contract to sell or otherwise dispose of, in the United States, any material amount of dollar-denominated debt securities issued or guaranteed by us which mature in more
than one year and which are substantially similar to the Notes.

Stabilization Transactions and Short Sales

In connection with the offering, the Underwriters, with the exception of Santander US Capital Markets LLC, may purchase and sell Notes in the
open market. These transactions may include short sales, stabilizing transactions and purchases to cover positions created by short sales. Short sales involve the sale by the Underwriters of a greater aggregate principal amount of Notes than they
are required to purchase from us in the offering. Stabilizing transactions consist of certain bids or purchases made for the purpose of preventing or retarding a decline in the market price of the Notes while the offering is in progress.

The Underwriters may also impose a penalty bid. This occurs when a particular Underwriter repays to the Underwriters a portion of the
underwriting discount received by it because the Underwriters have repurchased Notes sold by or for the account of such Underwriter in stabilizing or short-covering transactions.

S-45

These activities by the Underwriters may stabilize, maintain or otherwise affect the