Company: DNLI
Filing Date: 2025-02-27
Form Type: S-3ASR
Source: 0001628280-25-008647
Chunk: 0

Company: Denali Therapeutics Inc.
Filing Date: 2025-02-27
Form: S-3ASR
Chunk 0
---
<div align='center'>As filed with the Securities and Exchange Commission on February 27, 2025</div>

Registration No. 333-

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

#### FORM S-3
<div align='center'>REGISTRATION STATEMENT

Under

The Securities Act of 1933</div>

#### DENALI THERAPEUTICS INC.
<div align='center'>(Exact name of Registrant as specified in its charter)</div>

| Delaware                                                       |     | 46-3872213                          |
| (State or other jurisdiction of incorporation or organization) |     | -I.R.S. Employer Identification No. |

#### 161 Oyster Point Blvd.

#### South San Francisco, CA, 94080
<div align='center'>(650) 866-8547

(Address, including zip code, and telephone number, including area code, of Registrant's principal executive offices)</div>

#### Ryan J. Watts, Ph.D.

#### President and Chief Executive Officer

#### Denali Therapeutics Inc.

#### 161 Oyster Point Blvd.

#### South San Francisco, California 94080
<div align='center'>(650) 866-8547

(Name, address, including zip code, and telephone number, including area code, of agent for service)</div>

<div align='center'>Copies to:</div>

#### Tony Jeffries

#### Jennifer Knapp

#### Wilson Sonsini Goodrich & Rosati, P.C.

#### 650 Page Mill Road

#### Palo Alto, California 94304
<div align='center'>(650) 493-9300</div>

<div align='center'>APPROXIMATE DATE OF COMMENCEMENT OF PROPOSED SALE TO THE PUBLIC:

From time to time after the effective date of this Registration Statement.</div>

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. ☒

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement