Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 3

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 3
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3 |
| Description of Capital Stock                                      |     |      |     3 |
| Description of Depositary Shares                                  |     |      |     7 |
| Description of Debt Securities                                    |     |      |    10 |
| Description of the Warrants to Purchase Common Stock or Preferred 
 Stock                                                             |     |      |    17 |
| Description of the Warrants to Purchase Debt Securities           |     |      |    19 |
| Description of Stock Purchase Contracts and Stock Purchase        
 Units                                                             |     |      |    20 |
| Plan of Distribution                                              |     |      |    20 |
| ERISA Considerations                                              |     |      |    22 |
| Legal Matters                                                     |     |      |    24 |
| Experts                                                           |     |      |    24 |
| Where You Can Find More Information                               |     |      |    24 |

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ABOUT THIS PROSPECTUS SUPPLEMENT

This document consists of two parts. The first part is this prospectus supplement, which describes the specific terms of this offering of the
depositary shares and the Series B Preferred Stock represented by the depositary shares. The second part is the accompanying prospectus, which describes more general information, some of which may not apply to this offering. You should read both
this prospectus supplement and the accompanying prospectus, together with the additional information described under the heading “Where You Can Find More Information” below.

All references in this prospectus supplement to “Comerica,” the “Company,” “we,” “us,” “our”
or similar references mean Comerica Incorporated and its successors, but does not include our consolidated subsidiaries except where the context otherwise so requires.

If the information set forth in this prospectus supplement differs in any way from the information set forth in the accompanying prospectus,
you should rely on the information set forth in this prospectus supplement. If the information conflicts with any statement in a document which we have incorporated by reference, then you should only consider the statement in the more recent
document.

PRIIPs Regulation / Prohibition of Sales to EEA Retail Investors

The depositary shares are not intended to be offered, sold or otherwise made available to and should not be offered, sold or otherwise made
available to any retail investor in the European Economic Area (“EEA”). For these purposes, a retail investor means a person who is one (or more) of: (i) a retail client as defined in point (11) of Article