Company: INTS
Filing Date: 2025-06-12
Form Type: 424B5
Source: 0001628280-25-031040
Chunk: 45

Company: INTENSITY THERAPEUTICS, INC.
Filing Date: 2025-06-12
Form: 424B5
Chunk 45
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 sell our common stock in a public primary offering with a value exceeding more than one-third of our public float in any 12-month period so long as our public float remains below $75.0 million. As of July 2, 2024, the aggregate market value of our outstanding common stock held by non-affiliates, or public float, was approximately $47.1 million , based on 9,234,973 shares of our outstanding common stock that were held by non-affiliates on such date and a price of $5.10 per share, which was the price at which our common stock was last sold on The Nasdaq Capital Market on May 16, 2024 (a date within 60 days of the date hereof), calculated in accordance with General Instruction I.B.6 of Form S-3. As of the date of this prospectus, we have not offered or sold any securities pursuant to General Instruction I.B.6 of Form S-3 during the 12 calendar months prior to, and including, the date of this prospectus.

Investing in our securities involves a high degree of risk. You should review carefully the risks and uncertainties described under the heading “

#### Risk Factors

#### ” beginning on page

#### 5
of this prospectus and contained in the applicable prospectus supplement and any related free writing prospectus, and under similar headings in the other documents that are incorporated by reference into this prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.

This prospectus may not be used to consummate sales of securities unless it is accompanied by a prospectus supplement.

<div align='center'>The date of this prospectus is July 11 , 2024.</div>

### TABLE OF CONTENTS
| ABOUT THIS PROSPECTUS                              |     |  1 |
| ABOUT INTENSITY                                    |     |  2 |
| RISK FACTORS                                       |     |  5 |
| SPECIAL NOTE REGARDING FORWARD-LOOKING INFORMATION |     |  6 |
| USE OF PROCEEDS                                    |     |  8 |
| THE SECURITIES WE MAY OFFER                        |     |  9 |
| DESCRIPTION OF CAPITAL STOCK                       |     | 10 |
| DESCRIPTION OF DEBT SECURITIES                     |     | 14 |
| DESCRIPTION OF WARRANTS                            |