Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 408

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 408
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 Stock Acquisition JV LLC                                   |     |              | 1,472,281 |  -9 |     |        | 21.14 | % |     |                          | 29,057,097 |     |           | 100.00 | % |     |       | 30.36 | % |
| Oramed Pharmaceuticals Inc.                                     |     |              |   732,717 | -10 |     |        |  9.99 | % |     |                          |          — |     |           |      — |   |     |       |  8.87 | % |

| * | Less than 1%. |

| (1) | Unless otherwise indicated, the business address of each of the following individuals is 960 San Antonio Road, 
 Palo Alto, CA 94303.                                                                                           |

255

| (2) | Represents 307,909 shares subject to options exercisable within 60 days of March 31, 2025, 3,980 shares                        
 held directly and an aggregate of 4,453 shares held by family trusts for the benefit of Mr. Shah, his spouse and his children. |

| (3) | Represents 210,139 shares subject to options exercisable within 60 days of March 31, 2025, 9,147 shares                                                                                                                               
 held directly, an aggregate of 1,794 shares held through an entity owned by Dr. Ji, 161 shares held by Dr. Ji’s spouse and an aggregate of 8,350 shares held by family trusts for the benefit of Dr. Ji, his spouse and his children. |

| (4) | Represents 10,840 shares subject to options exercisable within 60 days of March 31, 2025 and 652 shares 
 held directly.                                                                                          |

| (5) | Represents 3,874 shares subject to options exercisable within 60 days of March 31, 2025 and 3,214 shares 
 held directly.                                                                                           |

| (6) | Represents 6,905 shares subject to options exercisable within 60 days of March 31, 2025 and 65 shares held 
 directly.                                                                                                  |

| (7) | Represents 1,339 shares subject to options exercisable within 60 days of March 31, 2025. |

| (8) | Represents 15,420 shares subject to options exercisable within 60 days of March 31, 202