Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 403

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 403
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person and Mr. Shah, our former Chief                                                                                                                     
 Executive Officer and President, are not included in this table, as each of them was our employee during the year presented and therefore received no compensation for his service as a director. Dr. Ji’s and Mr. Shah’s 
 compensation as named executive officers are included in the section titled “Executive and Director Compensation — Summary Compensation Table” above.                                                                     |

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| (2) | As of December 31, 2024, each of our current non-employee                                                                                        
 directors held options to purchase the following number of shares of our Common Stock: Dr. Chun: 2,857; Mr. Followwill: 5,685; and Dr. Wu: 2,857 |

| (3) | Mr. Lemus resigned from our Board effective November 27, 2024. As of December 31, 2024, Lemus 
 held options to purchase 71 shares of our Common Stock.                                       |

| (4) | Dr. Navani was appointed to our Board on July 21, 2024 and resigned on September 26, 2025. As of 
 December 31, 2024, Dr. Navani held options to purchase 7,142 shares of our Common Stock.         |

Non-EmployeeDirector Compensation Pursuant to our Non-EmployeeDirector Compensation Policy for the compensation of our non-employeedirectors, during 2024, each of our non-employeedirectors received annual retainers, subject to proration, for service on our Board and its committees as follows:

| Annual Cash Compensation                                                                    |     | Amount |        |
|:--------------------------------------------------------------------------------------------|:----|:-------|-------:|
| Board Members                                                                               |     | $      | 82,500 |
| Chairs of the Audit Committee, Compensation Committee, Nominating and Corporate Governance  
 Committee and Commercialization and Transaction Committee                                   |     | $      | 37,500 |
| Members of the Audit Committee, Compensation Committee, Nominating and Corporate Governance 
 Committee and Commercialization and Transaction Committee                                   |     | $      | 15,000 |
| Equity Compensation                                                                         |     | Number |        |
| Initial Stock Options                                                                       |     |        |  7,142 |
| Annual Stock Options                                                                        |     |        |  2,857 |

All annual cash compensation amounts for our non-employeedirectors are payable in equal quarterly installments in arrears, following the end of