Company: TAK
Filing Date: 2025-06-26
Form Type: 424B5
Source: 0001395064-25-000101
Chunk: 2

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-26
Form: 424B5
Chunk 2
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| WHERE YOU CAN FIND MORE INFORMATION                       |     |  3 |
| DESCRIPTION OF ISSUERS                                    |     |  4 |
| OFFERING INFORMATION                                      |     |  5 |
| RISK FACTORS                                              |     |  5 |
| USE OF PROCEEDS                                           |     |  5 |
| CAPITALIZATION AND INDEBTEDNESS                           |     |  6 |
| DESCRIPTION OF SENIOR DEBT SECURITIES AND GUARANTEE       |     |  7 |
| TAXATION                                                  |     | 25 |
| PLAN OF DISTRIBUTION                                      |     | 26 |
| LEGAL MATTERS                                             |     | 28 |
| EXPERTS                                                   |     | 28 |
| ENFORCEMENT OF CIVIL LIABILITIES                          |     | 28 |

No dealer, salesperson or other person is authorized to give any information or to represent anything not contained in this prospectus supplement and the accompanying prospectus. You must not rely on any unauthorized information or representations. This prospectus supplement and the accompanying prospectus are an offer to sell only the securities they describe, but only under circumstances and in jurisdictions where it is lawful to do so. The information contained in this prospectus supplement is current only as of its date.

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#### NOTICE TO PROSPECTIVE INVESTORS IN JAPAN
— The Notes have not been and will not be registered under the Financial Instruments and Exchange Act of Japan (Act No. 25 of 1948, as amended), or the FIEA, and may not be offered or sold in Japan or to, or for the benefit of, any person resident in Japan, or to others for re-offering or resale, directly or indirectly, in Japan or to, or for the benefit of, a person resident in Japan for Japanese securities law purposes (including any corporation or other entity organized under the laws of Japan) except pursuant to an exemption from the registration requirements of, and otherwise in compliance with, the FIEA and any other applicable laws, regulations and governmental guidelines of Japan.

#### PROHIBITION OF SALES TO EEA INVESTORS
— The Notes are not intended to be offered, sold or otherwise made available to and should not be offered, sold or otherwise made available to any retail investor in the European Economic Area (the “EEA”). For these purposes, a retail investor means a person who is one (or more) of: