Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 0

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 0
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#### Filed Pursuant to Rule 424(b)(2)

#### Registration No. 333-288301 and 333-288301-01

#### PROSPECTUS SUPPLEMENT

#### to Prospectus dated June 25, 2025.

#### TAKEDA U.S. FINANCING, INC.
<div align='center'>$1,650,000,000 5.200% Guaranteed Notes due 2035

$750,000,000 5.900% Guaranteed Notes due 2055</div>

#### Fully and Unconditionally Guaranteed by

### TAKEDA PHARMACEUTICAL COMPANY LIMITED
Takeda U.S. Financing, Inc., a Delaware corporation (“TUSFI” or the “Issuer”), will issue the above-listed notes (the “Notes”) pursuant to an indenture, to be dated on or around July 2, 2025 (the “TUSFI Indenture”). The Notes due 2035 are referred to herein as the “2035 Notes.” The Notes due 2055 are referred to herein as the “2055 Notes.” The Notes will bear interest at the fixed rates listed above in the manner described herein. TUSFI will pay interest on each series of the Notes semi-annually in arrears on January 7 and July 7 of each year, beginning on January 7, 2026.

Each series of the Notes will be TUSFI’s direct, unsecured and unsubordinated general obligations and will have the same rank in liquidation as all of its other current and future unsecured and unsubordinated obligations. Payment of the principal of and interest on the Notes is fully guaranteed (the “Guarantee”) by Takeda Pharmaceutical Company Limited (“TPC” or the “Guarantor”). The Guarantee will be the direct, unsecured and unsubordinated general obligation of TPC and will have the same rank in liquidation as all of its other current and future unsecured and unsubordinated obligations.

The Issuer may redeem a series of the Notes, in whole or in part, at any time prior to the applicable Par Call Date (as defined herein) at the applicable make-whole price determined in the manner described herein. The Issuer may also redeem some or all of each series of the Notes, in whole or in part, at any time on or after the applicable Par Call Date at a price equal to 100% of the respective principal amounts being redeemed plus accrued and unpaid interest to, but excluding,