Company: CERO
Filing Date: 2025-07-25
Form Type: 424B3
Source: 0001213900-25-067733
Chunk: 4

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-07-25
Form: 424B3
Chunk 4
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1 to the Company’s Current Report on Form 8-K (File No. 001-40877) filed on April 25, 2025).         |
| 10.1†   |     | Securities Purchase Agreement, dated of April 21, 2025, by and among CERo Therapeutics Holdings, Inc., and the investors signatory thereto (incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K (File No. 001-40877) filed on April 22, 2025). |
| 10.2†   |     | Form of Amendment to the Securities Purchase Agreement (incorporated by reference to Exhibit 10.2 of the Company’s Current Report on Form 8-K (File No. 001-40877) filed on June 30, 2025).                                                                                      |
| 104     |     | Cover Page Interactive Data File-the cover                                                                                                                                                                                                                                       
 page XBRL tags are embedded within the Inline XBRL document.                                                                                                                                                                                                                     |

| † | Certain                                                                                                                              
 portions of this document that constitute confidential information have been redacted pursuant to Item 601(b)(10) of Regulation S-K. |
| * | Filed                                                                                                                                
 herewith.                                                                                                                            |

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SIGNATURES</div>

Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

| Date: July 18, 2025 | CERO THERAPEUTICS HOLDINGS, INC. 
 By:                              | /s/ Chris Ehrlich       |
|:--------------------|:---------------------------------|:------------------------|
|                     |                                  | Chris Ehrlich           |
|                     |                                  | Chief Executive Officer |

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