Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 40

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 40
---
 underwriters, dealers or agents will be included in a prospectus supplement or free writing prospectus. If any underwriters, dealers or agents are involved in the sale of any securities, the applicable prospectus supplement will set forth any applicable commissions or discounts.

The applicable prospectus supplement will contain information, where applicable, as to any listing on any securities exchange of the senior debt securities covered by the prospectus supplement.

You should carefully consider the information contained under the heading “Item 3.D. Key Information—Risk Factors” in our most recent annual report on Form 20-F filed with the U.S. Securities and Exchange Commission (the “SEC”) and any additional risk factors incorporated by reference into this prospectus or contained in any applicable prospectus supplement(s) before you invest in any of the senior debt securities.

NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

<div align='center'>The date of this prospectus is June 25, 2025.</div>

### TABLE OF CONTENTS
| ABOUT THIS PROSPECTUS                                     |     |  1 |
| CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS |     |  2 |
| WHERE YOU CAN FIND MORE INFORMATION                       |     |  3 |
| DESCRIPTION OF ISSUERS                                    |     |  4 |
| OFFERING INFORMATION                                      |     |  5 |
| RISK FACTORS                                              |     |  5 |
| USE OF PROCEEDS                                           |     |  5 |
| CAPITALIZATION AND INDEBTEDNESS                           |     |  6 |
| DESCRIPTION OF SENIOR DEBT SECURITIES AND GUARANTEE       |     |  7 |
| TAXATION                                                  |     | 25 |
| PLAN OF DISTRIBUTION                                      |     | 26 |
| LEGAL MATTERS                                             |     | 28 |
| EXPERTS                                                   |     | 28 |
| ENFORCEMENT OF CIVIL LIABILITIES                          |     | 28 |

You should rely only on the information contained in or incorporated by reference into this prospectus, in any prospectus supplement or in any free writing prospectus. We have not authorized anyone to provide you with information different from that contained in or incorporated