Company: APM
Filing Date: 2025-12-05
Form Type: 424B5
Source: 0001213900-25-118752
Chunk: 0

Company: Aptorum Group Ltd
Filing Date: 2025-12-05
Form: 424B5
Chunk 0
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Filed pursuant to Rule 424(b)(5)

Registration No. 333-291593

<div align='center'>APTORUM GROUP LIMITED

December 5, 2025

Up to 2,060,000 Class A Ordinary Shares Upon Exercise of Certain Warrants</div>

Aptorum Group Limited (the “Company”), a holding company
incorporated in the Cayman Islands with its operations conducted by its subsidiaries is filing this prospectus for the offer and sale
from time to time by the selling securityholders named in this prospectus (and any of their pledgees, assignees, transferees and successors-in-interest)
(the “Selling Securityholders”) of up to 2,060,000 shares of its Class A Ordinary Shares, par value of $0.00001 each (the
“Class A Ordinary Shares”), issuable upon the exercise of (i) Ordinary Share Purchase Warrants to purchase up to 2,000,000
Class A Ordinary Shares (“Investor Warrant Shares”) at an original exercise price of $2.00 per share, subject to adjustment
(the “October 2025 Warrants”), issued by us to certain accredited investors on October 14, 2025 in a concurrent private placement
and registered direct transaction pursuant to a securities purchase agreement, dated as of October 10, 2025 (the “Purchase Agreement”)
and (ii) placement agent ordinary share purchase warrants (the “Placement Agent Warrants,” together with the October 2025
Warrants, the “2025 Warrants”) to purchase an aggregate of 60,000 Class A Ordinary Shares (the “Placement Agent Warrant
Shares,” together with the Investor Warrant Shares, the “2025 Warrant Shares”) issued to H.C. Wainwright & Co.,
LLC or its designees, as exclusive placement agent (the “Placement Agent”), at an exercise price of $2.50 per share. The Investor
Warrants are exercisable immediately and expire on the 5-year anniversary of the effective date of this registration statement. The Placement
Agent Warrants were exercisable immediately upon issuance on October 10, 2025, and expire on the earlier of 24 months from the effective
date of this registration statement or October 10, 2030.

We will not receive any proceeds
from the sale of shares of Class A Common Stock by the Selling Securityholders pursuant to this prospectus. We will, however, receive
the exercise price