Company: NDRA
Filing Date: 2025-10-30
Form Type: 424B5
Source: 0001213900-25-103705
Chunk: 2

Company: ENDRA Life Sciences Inc.
Filing Date: 2025-10-30
Form: 424B5
Chunk 2
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                            | S-20 |
| PLAN OF DISTRIBUTION                | S-21 |
| LEGAL MATTERS                       | S-23 |
| EXPERTS                             | S-23 |
| WHERE YOU CAN FIND MORE INFORMATION | S-23 |
| INCORPORATION BY REFERENCE          | S-24 |

Base Prospectus

| ABOUT THIS PROSPECTUS                                                                           |  1 |
| FORWARD-LOOKING STATEMENTS                                                                      |  2 |
| THE COMPANY                                                                                     |  4 |
| RISK FACTORS                                                                                    |  7 |
| USE OF PROCEEDS                                                                                 |  8 |
| DESCRIPTION OF SECURITIES WE MAY OFFER                                                          |  8 |
| DESCRIPTION OF COMMON STOCK WE MAY OFFER                                                        |  9 |
| DESCRIPTION OF PREFERRED STOCK WE MAY OFFER                                                     | 10 |
| DESCRIPTION OF DEBT SECURITIES WE MAY OFFER                                                     | 11 |
| DESCRIPTION OF WARRANTS WE MAY OFFER                                                            | 19 |
| DESCRIPTION OF UNITS WE MAY OFFER                                                               | 20 |
| CERTAIN PROVISIONS OF DELAWARE LAW AND OF THE COMPANY’S CERTIFICATE OF INCORPORATION AND BYLAWS | 21 |
| PLAN OF DISTRIBUTION                                                                            | 23 |
| LEGAL MATTERS                                                                                   | 25 |
| EXPERTS                                                                                         | 25 |
| WHERE YOU CAN FIND MORE INFORMATION                                                             | 25 |
| INCORPORATION BY REFERENCE                                                                      | 26 |

<div align='center'>S-i

ABOUT THIS PROSPECTUS SUPPLEMENT</div>

This document is in two parts. The first part
is this prospectus supplement, which describes the specific terms of the offering and common stock and the method of distribution of shares
of common stock sold in the offering. The second part is the accompanying prospectus, which gives more general information, some of which
may not apply to the offering or shares of common stock sold therein. Both documents contain important information you should consider
when making your investment decision.

This prospectus supplement and the accompanying
base prospectus forms part of a registration statement on Form S-3 that we filed with the U.S. Securities and Exchange Commission, or
the SEC, utilizing a “shelf” registration process. Under this shelf process, we may from time to time sell any combination
of securities described in this prospectus in one or more offerings.

In this prospectus supplement, the terms “ENDRA,”
“we,” “us,” “