Company: PSTV
Filing Date: 2025-04-23
Form Type: S-3/A
Source: 0001193125-25-091456
Chunk: 25

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-23
Form: S-3/A
Chunk 25
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 of this prospectus entitled “ Selling Stockholders,” together with any additional selling stockholders listed in a subsequent amendment to this prospectus, and their respective donees, pledgees, assignees, transferees or other successors-in-interestselling shares of common stock or interests in shares of common stock received after the date of this prospectus from a selling stockholder as a gift, pledge, partnership distribution or other transfer, may, from time to time, sell, transfer or otherwise dispose of any or all of their shares of common stock or interests in shares of common stock on any stock exchange, market or trading facility on which the shares are traded or in private transactions. These dispositions may be at fixed prices, at prevailing market prices at the time of sale, at prices related to the prevailing market price, at varying prices determined at the time of sale, or at negotiated prices. The selling stockholders may use any one or more of the following methods when disposing of their shares of common stock or interests therein:

| • |     | on any national securities exchange or quotation service on which the shares of common stock may be listed or 
 quoted at the time of sale;                                                                                   |

| • |     | in the over-the-counter market; |

| • |     | ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers; |

| • |     | block trades in which the broker-dealer will attempt to sell the shares of common stock as agent but may position 
 and resell a portion of the block as principal to facilitate the transaction;                                     |

| • |     | through brokers, dealers or underwriters that may act solely as agents; |

| • |     | purchases by a broker-dealer as principal and resale by the broker-dealer for its account; |

| • |     | an exchange distribution in accordance with the rules of the applicable exchange; |

| • |     | privately negotiated transactions; |

| • |     | delivery of shares in settlement of short sales; |

| • |     | in transactions through broker-dealers that agree with the selling stockholders to sell a specified number of 
 such shares of common stock at a stipulated price per security;                                               |

| • |     | through the writing or settlement of options or other hedging transactions, whether through an options exchange 
 or otherwise;                                                                                                   |

| • |     | a combination of any such methods of disposition; or |

| • |     | any other method permitted pursuant to applicable law. |

The selling stockholders may