Company: SCLXW
Filing Date: 2025-05-07
Form Type: POS AM
Source: 0001193125-25-115088
Chunk: 375

Company: Scilex Holding Co
Filing Date: 2025-05-07
Form: POS AM
Chunk 375
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 Initial Stock Options                                                                                                                                 |     |        |  7,142 |
| Annual Stock Options                                                                                                                                  |     |        |  2,857 |

All annual cash compensation amounts for our non-employeedirectors are payable in equal quarterly installments in arrears, following the end of each quarter in which the service occurred, pro-ratedfor any partial months of service. The equity compensation paid to our non-employeedirectors will vest monthly over a period of 48 months from the date of grant with respect to the initial stock option grants and over a period of 12 months from the date of grant with respect to the annual stock option grants, in each case, subject to continued service through each vesting date. Additionally, we will reimburse each outside director for reasonable travel expenses related to such director’s attendance at Board and committee meetings. Employee directors receive no additional compensation for their service as a director. 238

<div align='center'>**CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS**</div>

**The following is a summary of transactions since January 1, 2023 and any currently proposed transactions to which the Company was or is to be a participant in which the amount involved exceeded or will exceed $120,000 or one percent of the average of the Company’s total assets as of December 31, 2024 for the last two completed fiscal years, and in which any of the Company’s directors, executive officers or, to the Company’s knowledge, beneficial owners of more than 5% of the Company’s capital stock, or their immediate family members have had or will have a direct or indirect material interest, other than compensation and other arrangements that are described under the sections of this prospectus titled “Executive and Director Compensation.”

Stockholder Agreement with Sorrento

On September 12, 2022, Vickers entered into the Stockholder Agreement with Sorrento (the “Stockholder Agreement”).

Pursuant to the terms of the Stockholder Agreement, from and after the Effective Time, and for so long as Sorrento together with its affiliates, subsidiaries, successors and assigns (other than us and our subsidiaries) (the “Sorrento Group”) beneficially owns any shares of Series A Preferred Stock, among other things, (i) Sorrento had the right, but not the obligation, to designate each director to be nominated, elected or appointed to our Board (each, a “Stockholder Designee” and collectively, the “Stockholder Design