Company: ERAS
Filing Date: 2025-08-12
Form Type: S-3
Source: 0001193125-25-179038
Chunk: 41

Company: Erasca, Inc.
Filing Date: 2025-08-12
Form: S-3
Chunk 41
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; INCORPORATION BY 
 REFERENCE                                             |     | S-2  |
| PROSPECTUS SUMMARY                                    |     | S-4  |
| THE OFFERING                                          |     | S-5  |
| RISK FACTORS                                          |     | S-6  |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS  |     | S-8  |
| USE OF PROCEEDS                                       |     | S-9  |
| DILUTION                                              |     | S-10 |
| PLAN OF DISTRIBUTION                                  |     | S-11 |
| LEGAL MATTERS                                         |     | S-13 |
| EXPERTS                                               |     | S-13 |

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement that we filed on Form S-3 with the U.S. Securities and Exchange
Commission (the SEC), using a “shelf” registration process. By using a shelf registration statement, we may sell an unspecified amount of securities from time to time. Under this prospectus, we may offer and sell shares of our common
stock having an aggregate offering price of up to $200,000,000 from time to time through Jefferies acting as our agent at prices and on terms to be determined by market conditions at the time of the offering. The $200,000,000 of shares of our common
stock that may be sold under this prospectus are included in the $500,000,000 of shares of common stock that may be sold under the registration statement.

This prospectus relates to the offering of our common stock. Before buying any of the common stock that we are offering, we urge you to carefully read this
prospectus, together with the information incorporated by reference as described under the heading “Incorporation by Reference.” These documents contain important information that you should consider when making your investment decision.

This prospectus describes the specific details regarding this offering and also adds to and updates information contained in the documents incorporated
by reference into this prospectus. To the extent there is a conflict between the information contained in this prospectus, on the one hand, and the information contained in any document incorporated by reference in this prospectus, on the other
hand, you should rely on the information in this prospectus. If any statement in one of these documents is inconsistent with a statement in another document having a later date—for example, a document incorporated by reference into this
prospectus—the statement in the document