Company: PSTV
Filing Date: 2025-07-11
Form Type: PRE 14A
Source: 0001140361-25-025650
Chunk: 3

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-07-11
Form: PRE 14A
Chunk 3
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a) elect each board member nominee; and (b) vote to approve items (ii), (iii), (iv), and (v). In light of our successful virtual annual meetings of stockholders in the past four years, the Annual Meeting will be held only via live webcast again this year. We believe that the virtual meeting format also expands stockholder access, participation and improves communications, and we encourage you to attend online and participate.

TABLE OF CONTENTS

You will be able to attend and participate in the Annual Meeting online, vote your shares electronically, and submit your questions prior to and during the meeting by visiting: www.virtualshareholdermeeting.com/PSTV2025. To vote at the meeting, you must have your control number that is shown on your proxy card. There will not be a physical meeting location and you will not be able to attend the annual meeting in person. Only stockholders of record at the close of business on June 18, 2025, are entitled to notice of and to vote at the Annual Meeting. For ten (10) days prior to the Annual Meeting, a complete list of stockholders entitled to vote at the Annual Meeting will be available at the Corporate Secretary’s office at 2710 Reed Road Suite 160, Houston, TX 77002. We expect to commence mailing these proxy materials to our security holders on or about [ ], 2025. You are cordially invited to attend the Annual Meeting live via the Internet. It is important that your shares are represented at the Annual Meeting. Even if you plan to attend the Annual Meeting live via the Internet, we hope that you will promptly vote by dating, signing and returning the enclosed proxy card or vote via the Internet or by telephone. This will not limit your ability to attend or vote during the Annual Meeting. Plus Therapeutics, Inc.

| By Order of the Board,              |
| MARC H. HEDRICK                     |
| President & Chief Executive Officer |

Houston, Texas, USA July [•], 2025

TABLE OF CONTENTS

TABLE OF CONTENTS

|                                                                                                                                                                                                                   |     | Page |
| Questions and Answers About These Proxy Materials, Annual Meeting and Voting                                                                                                                                      |     |    2 |
| Corporate Governance                                                                                                                                                                                              |     |    9 |
| Director Candidates                                                                                                                                                                                               |     |    9 |
| Criteria for Board Membership                                                                                                                                                                                     |     |    9 |
| Biographical Information About Our Director Nominees                                                                                                                                                              |     |   10 |
|