Company: NCNA
Filing Date: 2025-04-24
Form Type: F-1
Source: 0001193125-25-092131
Chunk: 4

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-1
Chunk 4
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 cash exercise.

Notwithstanding the foregoing, including but not limited to the cashless exercise provisions of the Warrants and
Pre-Funded Warrants and the “zero exercise price” option provision of the Series B Warrant, under no circumstances shall the Warrants or Pre-Funded Warrants be exercised for an exercise price that is less than the product of (i) the number
of ordinary shares represented by each Warrant Share subject to delivery upon submission of any notice of exercise under the Warrants or Pre-Funded Warrants, multiplied by (ii) the nominal value per ordinary share, or the Mandatory Nominal Exercise
Price.

Because a purchaser’s purchase of ADSs in this offering could otherwise result in the purchaser, together with its affiliates
and certain related parties, beneficially owning more than 4.99% (or at the election of the purchaser, 9.99%) of our outstanding ADSs immediately following consummation of this offering, we are offering to the purchasers pre-funded warrants to purchase up to 16,049,383 ADSs, or the Pre-Funded Warrants, in lieu of ADSs. Each Pre-Funded Warrant will be
exercisable for one ADS. The purchase price of each Pre-Funded Warrant and accompanying Warrants is equal to the price per ADS and accompanying Warrants at which the ADSs and accompanying Warrants are being
sold to the public in this offering, minus the United States dollar equivalent of £0.01, based on the exchange rate on the date of pricing, and the exercise price of each Pre-Funded Warrant will be equal
to the United States dollar equivalent of £0.01, based on the exchange rate on the date of exercise. For each Pre-Funded Warrant that we sell, the number of ADSs offered will be decreased on a one-for-one basis. This offering also relates to the ADSs issuable upon exercise of the Warrants, or the Warrant Shares, and the ADSs issuable upon exercise of the Pre-Funded Warrants, or the Pre-Funded Warrant Shares.

Offering and ADSs Issuable in the Offering

This prospectus registers up to 16,049,383 ADSs, together with Series A Warrants to purchase up to 16,049,383
ADSs and Series B Warrants to purchase up to 16,049,383 ADSs. Each ADS, or Pre-Funded Warrant in lieu thereof, is being sold together with a Series A W