Company: SCLXW
Filing Date: 2025-05-07
Form Type: POS AM
Source: 0001193125-25-115095
Chunk: 420

Company: Scilex Holding Co
Filing Date: 2025-05-07
Form: POS AM
Chunk 420
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 securities as agent but may position and resell a portion of the block as principal to facilitate the transaction; |

260

| • |     | an over-the-counter distribution in accordance with the rules of Nasdaq; |

| • |     | through trading plans entered into by a Selling Securityholder pursuant to Rule 10b5-1 under the Exchange Act, that are in place at the time of an offering pursuant to this prospectus and any applicable prospectus supplement hereto that provide for periodic sales of their securities on the basis of parameters described in such trading plans; |

| • |     | through the distribution of the securities by any Selling Securityholder to its partners, members or stockholders; |

| • |     | through one or more underwritten offerings on a firm commitment or best efforts basis; |

| • |     | settlement of short sales entered into after the effective date of the registration statement of which this prospectus is a part; |

| • |     | agreements with broker-dealers to sell a specified number of the securities at a stipulated price per share or warrant; |

| • |     | in “at the market” offerings, as defined in Rule 415 under the Securities Act, at negotiated prices, at prices prevailing at the time of sale or at prices related to such prevailing market prices, including sales made directly on a national securities exchange or sales made through a market maker other than on an exchange or other similar offerings through sales agents; |

| • |     | in privately negotiated transactions; |

| • |     | in options transactions; |

| • |     | through a combination of any of the above methods of sale; or |

| • |     | any other method permitted pursuant to applicable laws. |

There can be no assurance that the Selling Securityholders will sell all or any of the securities offered by this prospectus. In addition, any shares that qualify for sale pursuant to Rule 144 may be sold under Rule 144 rather than pursuant to this prospectus. The Selling Securityholders have the sole and absolute discretion not to accept any purchase offer or make any sale of securities if they deem the purchase price to be unsatisfactory at any particular time. Subject to the terms of the agreement(s) governing the registration rights applicable to a Selling Securityholder’s shares of Common Stock, such Selling Securityholder may transfer shares of Common Stock to one or more “permitted transferees” in accordance with such agreements and, if so transferred, such permitted transferee(s) will be the selling beneficial