Company: FITBI
Filing Date: 2025-10-09
Form Type: 425
Source: 0001193125-25-234729
Chunk: 11

Company: FIFTH THIRD BANCORP
Filing Date: 2025-10-09
Form: 425
Chunk 11
---
 Change in Ownership on Form 4 filed with the SEC, which
are available at https://www.sec.gov/edgar/browse/?CIK=35527&owner=exclude, and at https://www.sec.gov/edgar/browse/?CIK=28412&owner=exclude.

Other information regarding the participants in the proxy solicitation and a description of their direct and indirect interests, by security
holdings or otherwise, will be contained in the Proxy Statement and other relevant materials to be filed with the SEC when they become available. You may obtain free copies of these documents through the website maintained by the SEC at
https://www.sec.gov.

NO OFFER OR SOLICITATION

This communication does not constitute an offer to sell or the solicitation of an offer to buy any securities or a solicitation of any
vote or approval, nor shall there be any sale of securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. No offer of
securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933, as amended.

| Date: October 8, 2025 |     | FIFTH THIRD BANCORP          
 (Registrant)                 
 /s/ Bryan D. Preston         |
|:----------------------|:----|:-----------------------------|
|                       |     | Bryan D. Preston             |
|                       |     | Executive Vice President and |
|                       |     | Chief Financial Officer      |

Exhibit 2.1

AGREEMENT AND PLAN OF MERGER

by and among

FIFTH THIRD BANCORP,

FIFTH THIRD FINANCIAL CORPORATION,

COMERICA INCORPORATED

and

COMERICA HOLDINGS INCORPORATED

Dated as of October 5, 2025

TABLE OF CONTENTS

| ARTICLE I THE MERGERS                                 |     |                                                    |     |  1 |
| 1.1.                                                  |     | Merger                                             |     |  1 |
| 1.2.                                                  |     | Time and Place of Closing                          |     |  2 |
| 1.3.                                                  |     | Effective Time                                     |     |  2 |
| 1.4.                                                  |     | Conversion of Common Stock                         |     |  2 |
| 1.5.                                                  |     | Conversion of