Company: LCTX
Filing Date: 2025-11-24
Form Type: 8-K
Source: 0001193125-25-291979
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Company: Lineage Cell Therapeutics, Inc.
Filing Date: 2025-11-24
Form: 8-K
Item: Item 8.01
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Item 8.01 Other Events.

As previously reported, in December 2021, Lineage Cell Therapeutics, Inc. (“we,” “us,” “our,” the “ Company,” or “ Lineage”), entered into a collaboration and license agreement with Genentech, Inc. and F. Hoffmann-La Roche Ltd. (the “ Roche Agreement”) under which our lead cell therapy program known as OpRegen® (also known as RG6501) is being developed for the treatment of ocular disorders, including geographic atrophy (“ GA”) secondary to age-related macular degeneration (“ AMD”). OpRegen is currently being evaluated in a Phase 2a multicenter clinical trial, known as “ GAlette”, in patients with GA secondary to AMD.

On November 20, 2025, the first development milestone under the Roche Agreement was achieved based on manufacturing and clinical advancements related to the OpRegen cell therapy program. This event triggered a $5 million milestone payment to Lineage, which is expected to be received by us within 30 days.

As previously reported, approximately 24.1% and 21.5% of the milestone payment will be paid to the Israel Innovation Authority and to Hadasit Medical Research and Development Ltd. (“ Hadasit”), respectively, in accordance with the Israeli Encouragement of Research, Development and Industrial Initiative Technology Law, 5744-1984, as amended, and in accordance with agreements between our subsidiary, Cell Cure Neuroscience Ltd., and Hadasit, respectively.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

                                                Lineage Cell Therapeutics, Inc.          
  Date:      November 24, 2025      By:         /s/ George A. Samuel III                 
                                    Name:       George A. Samuel III