Company: MTB-PJ
Filing Date: 2025-10-30
Form Type: 424B5
Source: 0001193125-25-257002
Chunk: 2

Company: M&T BANK CORP
Filing Date: 2025-10-30
Form: 424B5
Chunk 2
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 |     |      | S-30  |
| CERTAIN ERISA CONSIDERATIONS                         |     |      | S-34  |
| UNDERWRITING (CONFLICTS OF INTEREST)                 |     |      | S-36  |
| VALIDITY OF SECURITIES                               |     |      | S-42  |
| EXPERTS                                              |     |      | S-43  |

Prospectus

| ABOUT THIS PROSPECTUS               |     | 1 |
| ABOUT M&T BANK CORPORATION          |     | 1 |
| FORWARD-LOOKING STATEMENTS          |     | 2 |
| WHERE YOU CAN FIND MORE INFORMATION |     | 3 |
| RISK FACTORS                        |     | 5 |
| USE OF PROCEEDS                     |     | 5 |
| VALIDITY OF SECURITIES              |     | 5 |
| EXPERTS                             |     | 5 |

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ABOUT THIS PROSPECTUS SUPPLEMENT

You should read this prospectus supplement, the accompanying prospectus and the additional information described under the headings
“Where You Can Find Additional Information” and “Incorporation of Certain Information By Reference” before you make a decision to invest in the depositary shares. In particular, you should review the information under the
heading “Risk Factors” beginning on page S-6 of this prospectus supplement and the information under the heading “Risk Factors” included in our Annual Report on Form 10-K for the year ended December 31, 2024. Neither we nor the underwriters have authorized any other person to provide you with any information other than that contained or incorporated by
reference in this prospectus supplement, the accompanying prospectus or in any free writing prospectus that we prepare or distribute. Neither we nor the underwriters take any responsibility for, or provide any assurance as to the reliability of, any
other information that others may give you. You should assume that the information contained in this prospectus supplement and the accompanying prospectus is accurate only as of the date on the front of this prospectus supplement. Our business,
financial condition, results of operations and prospects may have changed since that date.

We are not, and the underwriters are not,
making an offer to sell the depositary shares in any jurisdiction where the offer or sale is not permitted. Neither this prospectus supplement nor the accompanying prospectus constitutes an offer of, or an invitation on our behalf or on behalf of
the underwriters