Company: DRTSW
Filing Date: 2025-04-28
Form Type: 424B5
Source: 0001213900-25-035799
Chunk: 53

Company: Alpha Tau Medical Ltd.
Filing Date: 2025-04-28
Form: 424B5
Chunk 53
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 of this prospectus supplement unless the information specifically indicates that
another date applies. You should read all information supplementing this prospectus supplement.

<div align='center'>S-33

PROSPECTUS

$200,000,000

Ordinary Shares

Warrants to Purchase Ordinary Shares

Debt Securities

Subscription Rights and/or Units

Offered by the Company</div>

We may offer and sell to the
public from time to time in one or more series or issuances up to $200,000,000 in the aggregate of ordinary shares, warrants, debt securities,
subscription rights and/or units consisting of two or more of these classes or series of securities.

We refer to the ordinary shares,
warrants, subscription rights and units collectively as “securities” in this prospectus.

Each time we sell securities
pursuant to this prospectus, we will provide a supplement to this prospectus that contains specific information about the offeror, the
offering and the specific terms of the securities offered. This prospectus may not be used to consummate a sale of securities by us unless
accompanied by the applicable prospectus supplement. You should read this prospectus and the applicable prospectus supplement carefully
before you invest in our securities.

We may, from time to time,
offer to sell the securities, through public or private transactions, directly or through underwriters, agents or dealers, on or off the
Nasdaq Capital Market, as applicable, at prevailing market prices or at privately negotiated prices. If any underwriters, agents or dealers
are involved in the sale of any of these securities, the applicable prospectus supplement will set forth the names of the underwriter,
agent or dealer and any applicable fees, commissions or discounts. For general information about the distribution of securities offered,
please see “Plan of Distribution” beginning on page 22 of this prospectus.

Our ordinary shares and warrants
are listed on the Nasdaq Capital Market under the trading symbols “DRTS” and “DRTSW,” respectively. On March 30,
2023, the closing prices for our ordinary shares and warrants on the Nasdaq Capital Market were $2.90 per ordinary share and $0.3267 per
warrant.

We are an “emerging
growth company” and a “foreign private issuer” as defined under the U.S. Securities and Exchange Commission, or the
SEC, and, as such, we have elected to comply with certain reduced public company reporting requirements for this prospectus and