Company: NCNA
Filing Date: 2025-05-02
Form Type: F-1/A
Source: 0001193125-25-110310
Chunk: 75

Company: NuCana plc
Filing Date: 2025-05-02
Form: F-1/A
Chunk 75
---
                                                                                        |

| d. | If the Trading Price is at least one hundred fifty percent (150%) above the Floor Price, the Daily Limit shall 
 be fifty percent (50%);                                                                                        |

| e. | If the Trading Price is at least two hundred percent (200%) above the Floor Price, the Daily Limit shall be 
 sixty percent (60%);                                                                                        |

| f. | If the Trading Price is at least two hundred fifty percent (250%) above the Floor Price, the Daily Limit shall 
 be seventy percent (70%);                                                                                      |

| g. | If the Trading Price is at least three hundred percent (300%) above the Floor Price, the Daily Limit shall be 
 eighty percent (80%);                                                                                         |

| h. | If the Trading Price is at least three hundred fifty percent (350%) above the Floor Price, the Daily Limit 
 shall be ninety percent (90%); and                                                                         |

| i. | If the Trading Price is at least four hundred percent (400%) above the Floor Price, there shall be no Daily                       
 Limit and all Series B Warrant holders shall be permitted to exercise its Series B Warrants in accordance with the terms thereof. |

Notwithstanding the foregoing, on any given day, the aggregate number of Warrant Shares permitted to be issued pursuant to the Daily Limit for such day shall be limited to the Series B Warrant holder’s pro rata portion of the Series B Warrants purchased by the Series B Warrant holder on the closing date of this offering relative to the total number of Series B Warrants sold by us on the closing date of this offering. For purposes of determining 52

the Daily Limit, the “Trading Price” shall mean the VWAP (as defined in the Series B Warrant) of the ADSs over the five consecutive trading days immediately preceding the applicable
date of exercise. Upon the expiration of the Lock-Up Period, there shall be no Daily Limit and the Series B Warrant holder shall be permitted to exercise its Series B Warrants in accordance with the terms thereof. We do not have any obligation to
monitor or enforce compliance by the Series B Warrant holder with the terms of the Lock-Up Agreement, including, without limitation, the volume-based daily issuance limitations set forth above, or to provide any notice of such information to the
Series B Warrant holder. We will not be liable to the Series B Warrant holder with respect to (i) any information regarding our securities or the volume-based daily issuance limitations set forth above provided by