Company: CNTB
Filing Date: 2025-06-10
Form Type: S-8
Source: 0001193125-25-138485
Chunk: 6

Company: Connect Biopharma Holdings Ltd
Filing Date: 2025-06-10
Form: S-8
Chunk 6
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 initial bona fide offering thereof.                                                                                                                                                                               |

| (c) | Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors,                                                                                                                                                
 officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities 
 Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the 
 successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been       
 settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. |

SIGNATURES Pursuant to the requirements of the Securities Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of San Diego, State of California, on June 10, 2025.

| CONNECT BIOPHARMA HOLDINGS LIMITED |     |                    |
| By:                                |     | /s/ Barry D. Quart |
| Name: Barry D. Quart, Pharm.D.     |     |                    |
| Title: Chief Executive Officer     |     |                    |

POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Barry D. Quart, Pharm.D. and Lisa Peraza, CPA and each of them, individually, as his or her true and lawful attorneys-in-factand agents, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead in any and all capacities, in connection with this registration statement, including to sign in the name and on behalf of the undersigned, this registration statement and any and all amendments thereto, including post-effective amendments, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the U