Company: APM
Filing Date: 2025-01-03
Form Type: 424B5
Source: 0001213900-25-000606
Chunk: 2

Company: Aptorum Group Ltd
Filing Date: 2025-01-03
Form: 424B5
Chunk 2
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 before you make your investment decision.

Neither the Securities and Exchange Commission, the Cayman Islands Monetary Authority, nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

|                                    |     | Per Class A Ordinary 
 Share                |      |     | Total |           |
|:-----------------------------------|:----|:---------------------|-----:|:----|:------|----------:|
| Public offering price              |     | $                    | 2.00 |     | $     | 3,070,000 |
| Placement Agent fees(1)            |     | $                    | 0.14 |     | $     |   214,900 |
| Proceeds to us, before expenses(2) |     | $                    | 1.86 |     | $     | 2,855,100 |

| (1) | We have agreed to pay the Placement Agent a cash fee equal to seven percent (7.0%) of the aggregate gross proceeds of 
 this offering.                                                                                                        |

| (2) | We have agreed to pay all expenses relating to the placement, which includes up to $50,000 for reasonable 
 legal fees and disbursements for Placement Agent’s counsel.                                               |

We expect that delivery of the Class A Ordinary
Shares being offered pursuant to this prospectus supplement and the accompanying prospectus will be made on or about January 3, 2025,
subject to customary closing conditions.

<div align='center'>Maxim Group LLC

The date of this prospectus supplement is January 2, 2025.

TABLE OF CONTENTS

Prospectus Supplement</div>

|                                                      | Page  |
| ABOUT THIS PROSPECTUS SUPPLEMENT                     | S-ii  |
| CAUTIONARY NOTE REGARDING FORWARD LOOKING STATEMENTS | S-iii |
| PROSPECTUS SUPPLEMENT SUMMARY                        | S-1   |
| THE OFFERING                                         | S-5   |
| RISK FACTORS                                         | S-6   |
| CAPITALIZATION                                       | S-8   |
| USE OF PROCEEDS                                      | S-9   |
| DILUTION                                             | S-9   |
| DESCRIPTION OF OUR SECURITIES WE ARE OFFERING        | S-10  |
| PLAN OF DISTRIBUTION                                 | S-11  |
| LEGAL MATTERS                                        | S-13  |
| EXPERTS