Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 339

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 339
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 and Nonqualified Deferred Compensation

We maintain a defined contribution 401(k) plan available to eligible employees. Employee contributions are voluntary and are determined on an
individual basis, limited to the maximum amount allowable under federal tax regulations. We made matching contributions to the 401(k) plan totaling $0.6 million and $0.5 million for each of the years ended December 31, 2024 and 2023,
respectively.

Mr. Shah, Dr. Ji and Mr. Ma participate in our tax-qualified
Section 401(k) plan and we provide a 4% matching contribution up to an annual compensation limit ($345,000 in 2024).

We do not
provide any other pension plan for our employees, and none of our named executive officers participated in a nonqualified deferred compensation plan during the year ended December 31, 2024.

217

Outstanding Equity Awards at Fiscal Year-End2024 The following table presents certain information concerning outstanding equity awards held by each of our named executive officers as of December 31, 2024. Following the Business Combination, each outstanding equity award with respect to our Common Stock reflected in the table below was equitably adjusted in accordance with the terms of the Merger Agreement and the 2019 Stock Option Plan.

| Name            |     | Option     
 Grant Date |            |     | Vesting      
 Commencement 
 Date         |            |    |     | Option Awards(1)(2) 
 Number of           
 Securities          
 Underlying          
 Unexercised Options 
 (#) Exercisable     |         |     | Number of           
 Securities          
 Underlying          
 Unexercised Options 
 (#) Unexercisable   |         |     | Option             
 Exercise Price Per 
 Share ($)          |        |     | Option     
 Expiration 
 Date       |            |
|:----------------|:----|:-----------|:-----------|:----|:-------------|:-----------|---:|:----|:--------------------|--------:|:----|:--------------------|--------:|:----|:-------------------|-------:|:----|:-----------|:-----------|
| Jaisim Shah     |     |            | 6/6/2019   |     |              | 3/18/2019  | -3 |     |                     | 232,195 |     |                     |       — |     | $                  |  60.55 |     |            | 6/6/2029