Company: TAK
Filing Date: 2025-06-26
Form Type: 424B5
Source: 0001395064-25-000101
Chunk: 81

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-26
Form: 424B5
Chunk 81
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 OFFICE
<div align='center'>Takeda Pharmaceutical Company Limited

1-1, Doshomachi 4-chome

Chuo-ku, Osaka

540-8545, Japan</div>

### OUR LEGAL ADVISORS
| As to Japanese Law:                       |     | As to U.S. Law:            |
| Nishimura & Asahi (Gaikokuho Kyodo Jigyo) 
 Otemon Tower                              
 1-2, Otemachi 1-chome                     
 Chiyoda-ku, Tokyo 100-8124                
 Japan                                     |     | Sullivan & Cromwell LLP    
 Otemachi First Square      
 1-5-1 Otemachi             
 Chiyoda-ku, Tokyo 100-0004 
 Japan                      |

### LEGAL ADVISORS TO THE UNDERWRITERS
<div align='center'>As to U.S. Law:</div>

#### Simpson Thacher & Bartlett LLP
<div align='center'>Ark Hills Sengokuyama Mori Tower

9-10, Roppongi 1-chome

Minato-ku, Tokyo 106-0032

Japan

TRUSTEE, PAYING AGENT, TRANSFER AGENT AND REGISTRAR</div>

#### The Bank of New York Mellon
<div align='center'>240 Greenwich Street

New York, NY 10286</div>

### INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

### KPMG AZSA LLC
<div align='center'>AZSA Center Building

1-2, Tsukudo-cho

Shinjuku-ku, Tokyo 162-8551

Japan</div>

#### TAKEDA U.S. FINANCING, INC.
<div align='center'>$ % Guaranteed Notes due 2035

$ % Guaranteed Notes due 2055</div>

#### Fully and Unconditionally Guaranteed by

### TAKEDA PHARMACEUTICAL COMPANY LIMITED
<div align='center'>Joint Lead Managers and Joint Bookrunners</div>

| J.P. Morgan |     | SMBC NIKKO |