Company: TXG
Filing Date: 2025-04-14
Form Type: DEF 14A
Source: 0001770787-25-000018
Chunk: 0

Company: 10x Genomics, Inc.
Filing Date: 2025-04-14
Form: DEF 14A
Chunk 0
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### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549
#### ______________________

#### SCHEDULE 14A

#### Proxy Statement Pursuant to Section 14(a) of the

#### Securities Exchange Act of 1934
#### ______________________

| Filed by the Registrant |     | x |     | Filed by a Party other than the Registrant |     | o |

| Check the appropriate box: |     |                                                                                 |
| o                          |     | Preliminary Proxy Statement                                                     |
| o                          |     | Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) |
| x                          |     | Definitive Proxy Statement                                                      |
| o                          |     | Definitive Additional Materials                                                 |
| o                          |     | Soliciting Material Pursuant to §240.14a-12                                     |

#### 10x Genomics, Inc.
<div align='center'>(Name of Registrant as Specified In Its Charter)</div>

| Payment of Filing Fee (Check the appropriate box): |     |                                                                                                   |
| x                                                  |     | No fee required.                                                                                  |
| o                                                  |     | Fee paid previously with preliminary materials.                                                   |
| o                                                  |     | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i) and 0-11. |

April 14, 2025

To Stockholders of 10x Genomics, Inc.:

Our 2025 Annual Meeting of Stockholders (“2025 Annual Meeting”) will be held on Tuesday, June 3, 2025 at 1:30 p.m. PDT. The 2025 Annual Meeting will be conducted exclusively online via a live webcast. You will be able to attend the meeting, submit your questions online during the meeting and vote your shares electronically at the meeting by visiting https://web.lumiconnect.com/213535898. Because the meeting is completely virtual and being conducted via the internet, stockholders will not be able to attend the meeting physically in person. The attached notice and proxy statement describe the formal business to be transacted at the meeting.

Whether or not you attend the virtual 2025 Annual Meeting, it is important that your shares be represented and voted at the meeting. Therefore, I urge you to vote promptly and submit your proxy via regular mail, online or by telephone. The 2025 Annual Meeting