Company: PSTV
Filing Date: 2025-05-15
Form Type: NT 10-Q
Source: 0000950170-25-072596
Chunk: 1

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-05-15
Form: NT 10-Q
Chunk 1
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 will be filed on or before the fifth calendar day following the prescribed due date; and |
|   | -c | The accountant’s statement or other exhibit required by Rule 12b-25(c) has been attached if applicable.                                                                                                                                                                                                                                                                                                                                                                 |

PART III -- NARRATIVE State below in reasonable detail why Forms 10-K, 20-F, 11-K, 10-Q, 10-D, N-CEN, N-CSR, or the transition report or portion thereof, could not be filed within the prescribed time period. Plus Therapeutics, Inc. (the “Company”) is filing this Notification of Late Filing on Form 12b-25 with respect to its Quarterly Report on Form 10-Q for the quarter ended March 31, 2025 (the “Quarterly Report”). The Company requires additional time to finalize the accounting treatment in respect of common stock purchase warrants issued pursuant to that certain securities purchase agreement, dated March 4, 2025, among the Company and the purchasers signatory thereto (the “March 2025 PIPE Transaction”). As a result of the foregoing, the Company is unable, without unreasonable effort or expense, to file its Quarterly Report by the prescribed due date of May 15, 2025. The Company is working diligently to complete the Form 10-Q as soon as possible. 2

PART IV -- OTHER INFORMATION

| (1) | Name and telephone number of person to contact in regard to this notification |

| Marc H. Hedrick, M.D. |     |       -737 |     | 255-7194          |
| (Name)                |     | -Area Code |     | -Telephone Number |

| (2) | Have all other periodic reports required under Section 13 or 15(d) of the Securities Exchange Act of 1934 or Section 30 of the Investment Company Act of 1940 during the preceding 12 months or for such shorter period that the registrant was required to file such report(s) been filed? If answer is no, identify report(s). Yes ☒ No ☐ |

3

PLUS THERAPEUTICS, INC. (Name of Registrant as Specified in Charter) has caused this notification to be signed on its behalf by the undersigned hereunto duly authorized.

| Date | May 15, 2025 |     | By: | /s/ Marc H. Hedrick, M.D.                                |
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