Company: SRPT
Filing Date: 2025-08-06
Form Type: S-8
Source: 0001193125-25-174466
Chunk: 2

Company: Sarepta Therapeutics, Inc.
Filing Date: 2025-08-06
Form: S-8
Chunk 2
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 | Chief Executive Officer |

SIGNATURES AND POWERS OF ATTORNEY Each person whose signature appears below hereby constitutes and appoints Douglas S. Ingram, Ian M. Estepan and Cristin L. Rothfuss, and each of them singly, his or her true and lawful attorney-in-factand agent with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8of Sarepta Therapeutics, Inc., and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-factand agents full power and authority to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-factand agents, or their substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed below by the following persons in the capacities indicated below on the dates indicated:

| Signature                      
 /s/ Douglas S. Ingram          
 Douglas S. Ingram              
 /s/ Ryan H. Wong               
 Ryan H. Wong                   |     | Title                                             
 Chief Executive Officer, Director (Principal      
 Executive Officer)                                
 Executive Vice President, Chief Financial Officer 
 (Principal Financial and Accounting Officer)      |     | Date           
 August 6, 2025 
 August 6, 2025 |
|:-------------------------------|:----|:--------------------------------------------------|:----|:---------------|
| /s/ M. Kathleen Behrens, Ph.D. 
 M. Kathleen Behrens, Ph.D.     |     | Chairwoman of the Board                           |     | August 6, 2025 |
| /s/ Richard J. Barry           
 Richard J. Barry               |     | Director                                          |     | August 6, 2025 |
| /s/ Kathryn Boor, Ph.D.        
 Kathryn Boor, Ph.D.            |     | Director                                          |     | August 6, 2025 |
| /s/ Deirdre Connelly           
 Deirdre Connelly               |     | Director                                          |     | August 6, 2025 |
| /s/ Michael Chambers           
 Michael