Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 80

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 80
---
 States, substantially all of the assets of TPC are located outside the United States. As a result, it may not be possible for investors to effect service of process within the United States or elsewhere outside Japan upon TPC or its directors and executive officers or to enforce against it or such persons judgments obtained in the United States courts or elsewhere, whether or not predicated upon the civil liability provisions of the United States securities laws or other laws of the United States or any state thereof. Nishimura & Asahi (Gaikokuho Kyodo Jigyo), our Japanese counsel, has advised us that, in original actions or in actions for enforcement of judgments of U.S. federal or state courts brought before Japanese courts, there is in general doubt as to the enforceability of liabilities based solely on U.S. federal and state securities laws.

TPC’s agent for service of process is Takeda Pharmaceuticals U.S.A., Inc. (or any successor thereto).

<div align='center'>-28-</div>

#### TPC’s REGISTERED HEAD OFFICE
<div align='center'>Takeda Pharmaceutical Company Limited

1-1, Doshomachi 4-chome

Chuo-ku, Osaka

540-8545, Japan</div>

### OUR LEGAL ADVISORS
| As to Japanese Law:                       |     | As to U.S. Law:            |
| Nishimura & Asahi (Gaikokuho Kyodo Jigyo) 
 Otemon Tower                              
 1-2, Otemachi 1-chome                     
 Chiyoda-ku, Tokyo 100-8124                
 Japan                                     |     | Sullivan & Cromwell LLP    
 Otemachi First Square      
 1-5-1 Otemachi             
 Chiyoda-ku, Tokyo 100-0004 
 Japan                      |

### LEGAL ADVISORS TO THE UNDERWRITERS
<div align='center'>As to U.S. Law:</div>

#### Simpson Thacher & Bartlett LLP
<div align='center'>Ark Hills Sengokuyama Mori Tower

9-10, Roppongi 1-chome

Minato-ku, Tokyo 106-0032

Japan

TRUSTEE, PAYING AGENT, TRANSFER AGENT AND REGISTRAR</div>

#### The Bank of New York Mellon
<div align='center'>240 Greenwich Street

New York, NY 10286</div>

### INDEPENDENT REGISTERED PUBLIC ACCOUNTING