Company: XOMAP
Filing Date: 2025-10-03
Form Type: 424B5
Source: 0001193125-25-230393
Chunk: 61

Company: XOMA Royalty Corp
Filing Date: 2025-10-03
Form: 424B5
Chunk 61
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 the prospectus supplement related to such offering will set forth our intended use of the proceeds, if any, received from the sale of such securities.

5

DESCRIPTION OF SECURITIES WE MAY OFFER We may offer any combination of the following securities, with a total value of up to $200,000,000, from time to time in one or more offerings under this prospectus at prices and on terms to be determined at the time of any offering:

| • |     | common stock; |

| • |     | preferred stock; |

| • |     | depositary shares; |

| • |     | debt securities; |

| • |     | warrants to purchase common stock, preferred stock, depositary shares or debt securities, or; |

| • |     | subscription rights to purchase common stock, preferred stock, depositary shares or debt securities; |

| • |     | contingent value rights; |

| • |     | royalty certificates; and |

| • |     | units comprised of any combination of our common stock, preferred stock, depositary shares, debt securities, 
 warrants, subscription rights, contingent value rights and royalty certificates.                             |

This prospectus provides you with a general description of the securities we may offer. Each time we offer a type or series of securities under this prospectus, we will provide a prospectus supplement that will describe the specific amounts, prices and other important terms of the securities, including, to the extent applicable:

| • |     | designation or classification; |

| • |     | aggregate principal amount or aggregate offering price; |

| • |     | maturity date, if applicable; |

| • |     | original issue discount, if any; |

| • |     | rates and times of payment of interest or dividends, if any; |

| • |     | redemption, conversion, exercise, exchange or sinking fund terms, if any; |

| • |     | ranking; |

| • |     | restrictive covenants, if any; |

| • |     | voting or other rights, if any; |

| • |     | conversion or exchange prices or rates, if any, and, if applicable, any provisions for changes to or adjustments                  
 in the conversion or exchange prices or rates and in the securities or other property receivable upon conversion or exchange; and |

| • |     | a discussion of material United States federal income tax considerations, if any. |

The applicable prospectus supplement and any related free writing prospectus that we may authorize to be