Company: HRTX
Filing Date: 2025-09-09
Form Type: S-3
Source: 0000950170-25-113830
Chunk: 3

Company: HERON THERAPEUTICS, INC. /DE/
Filing Date: 2025-09-09
Form: S-3
Chunk 3
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 this prospectus any similar section contained in the applicable prospectus supplement and in any free writing prospectuses we have authorized for use in connection with a specific offering, and under similar headings in the documents that are incorporated by reference into this prospectus. You should carefully read this prospectus, the applicable prospectus supplement and any related free writing prospectus, as well as the documents incorporated by reference herein and therein, before you invest in any of our securities.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is , 2025</div>

TABLE OF CONTENTS

|                                                   |     | Page |
| About this Prospectus                             |     |   ii |
| Forward-looking Statements                        |     |    1 |
| Prospectus Summary                                |     |    4 |
| Risk Factors                                      |     |   15 |
| Use of Proceeds                                   |     |   16 |
| Selling Stockholders                              |     |   17 |
| Plan of Distribution                              |     |   19 |
| Description of Capital Stock                      |     |   21 |
| Where You Can Find More Information               |     |   26 |
| Incorporation of Certain Information by Reference |     |   27 |
| Legal Matters                                     |     |   28 |
| Experts                                           |     |   28 |

<div align='center'>i

ABOUT THISPROSPECTUS</div>

This prospectus is part of a registration statement on Form S-3 that we filed with the U.S. Securities and Exchange Commission (the “SEC”), using a “shelf” registration process. Under a shelf registration process, the Selling Stockholders may from time to time sell the shares of Common Stock described in this prospectus in one or more offerings.

This prospectus provides you with a general description of the securities that may be sold by the Selling Stockholders. Each time the Selling Stockholders sell the securities, to the extent required by law, a prospectus supplement will be provided that will contain specific information about the terms of the offering. One or more free writing prospectuses may also be provided to you in connection with the offering. The prospectus supplement and any related free writing prospectus may add, update or change information contained in this prospectus. This prospectus does not contain all of the information included in the registration