Company: SPRB
Filing Date: 2025-10-29
Form Type: S-3
Source: 0001193125-25-256662
Chunk: 0

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-10-29
Form: S-3
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on October 29, 2025</div>

Registration No. 333-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Spruce Biosciences, Inc. (Exact name of registrant as specified in its charter)

| Delaware                                                       |     | 81-2154263                             |
| (State or other jurisdiction of incorporation or organization) |     | -I.R.S. Employer Identification Number |

611 Gateway Boulevard, Suite 740 South San Francisco, California 94080 (415) 655-4168 (Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices) Javier Szwarcberg, M.D., MPH Chief Executive Officer Spruce Biosciences, Inc. 611 Gateway Boulevard, Suite 740 South San Francisco, California 94080 (415) 655-4168 (Name, address, including zip code, and telephone number, including area code, of agent for service) Copies to:

| Katherine DenbyAlexander GefterCooley LLP1333 2nd Street, Suite 400Santa Monica, CA  90401(310) 883-6400 | Samir GharibPresident and Chief Financial Officer611 Gateway Boulevard, Suite 740South San Francisco, California 94080 (415) 655-4168 |

From time to time after the effective date of this Registration Statement (Approximate date of commencement of proposed sale to the public) If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐ If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. ☒ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the