Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 158

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 158
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 approval, dividend, or other rights or preferences superior to the rights of other stockholders; |

| • |     | provide for a classified board of directors with staggered three-year terms; |

| • |     | provide that directors may only be removed for cause, and only by the affirmative vote of holders of at least 66                          
 2/3% in voting power of all the then-outstanding shares of our capital stock entitled to vote thereon, voting together as a single class; |

| • |     | prohibit stockholder action by written consent; |

| • |     | provide that special meetings may only be called by or at the direction of the Chairperson of the Board, the 
 Board or the Chief Executive Officer;                                                                        |

| • |     | provide that any alteration, amendment or repeal, in whole or in part, of any provision of the Bylaws by our                                                                                                               
 stockholders will require the affirmative vote of the holders of at least 66 2/3% in voting power of all the then-outstanding shares of our capital stock entitled to vote thereon, voting together as a single class; and |

96

| • |     | establish advance notice requirements for nominations for elections to the Board and for proposing matters that 
 can be acted upon by stockholders at stockholder meetings.                                                      |

Section 203 of the DGCL generally prohibits a Delaware corporation from engaging in any of a broad range of business combinations with any interested stockholder for a period of three years following the date on which the stockholder became an interested stockholder. We are governed by Section 203 of the DGCL, except that the restrictions on business combinations of Section 203 of the DGCL will not apply to Sorrento or its current or future Affiliates (as defined in the Certificate of Incorporation) regardless of its percentage ownership of our Common Stock. These provisions could discourage, delay or prevent a transaction involving a change in control of the Company. These provisions could also discourage proxy contests and make it more difficult for our stockholders to elect directors of their choosing and cause us to take other corporate actions they desire, including actions that our stockholders may deem advantageous. In addition, because our Board is responsible for appointing the members of our management team, these provisions could in turn affect any attempt by our stockholders to replace current members of our management team. These anti-takeover provisions and other provisions in the Certificate of Incorporation, the Bylaws and Delaware law could make it more difficult for stockholders