Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 81

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 81
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 the Warrants are urged to consult their own tax advisers. The discussion below of the U.S. federal income tax consequences to “U.S. Holders” will apply to an investor that is a beneficial owner of ADSs, Pre-FundedWarrants, or Warrants and that is, for U.S. federal income tax purposes,

| • |     | an individual who is a citizen or resident of the United States; |

| • |     | a corporation (or other entity taxable as a corporation for U.S. federal income tax purposes) organized under the 
 laws of the United States, any state therein or the District of Columbia;                                         |

| • |     | an estate whose income is subject to U.S. federal income taxation regardless of its source; or |

| • |     | a trust that (i) is subject to the primary supervision of a court within the United States and subject to                                                                               
 the control of one or more U.S. persons for all substantial decisions or (ii) has a valid election in effect under applicable U.S. Treasury Regulations to be treated as a U.S. person. |

For U.S. federal income tax purposes, a beneficial owner of ADSs generally will be treated as the owner of the underlying ordinary shares represented by such ADSs. Accordingly, deposits or withdrawals of the underlying ordinary shares for ADSs generally will not be subject to U.S. federal income tax. The discussion below assumes that the representations contained in the deposit agreement are true and that the obligations in the deposit agreement and any related agreement will be complied with in accordance with their terms. U.S. Treasury has expressed concerns that parties to whom ADSs are released before shares are delivered to the depositary or 56

intermediaries in the chain of ownership between the U.S. Holder of an ADS and the issuer of the security underlying the ADS may be taking actions that are inconsistent with the claiming of
foreign tax credits by U.S. Holders of ADSs. These actions would also be inconsistent with the claiming of the reduced rate of tax, described below, applicable to dividends received by certain noncorporate U.S. Holders. As a result, the
creditability of non-U.S. withholding taxes (if any), and the availability of the reduced tax rate for dividends received by certain non-corporate U.S. Holders, each
described below, could be affected by actions taken by such parties or intermediaries. Accordingly, U.S. persons considering an investment in ADSs or Pre-Funded