Company: FITBI
Filing Date: 2025-11-05
Form Type: S-4
Source: 0001193125-25-267273
Chunk: 399

Company: FIFTH THIRD BANCORP
Filing Date: 2025-11-05
Form: S-4
Chunk 399
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 (copies of which are on file at the office of the Registrar) to all of which the holder of this certificate by acceptance hereof assents. This certificate is not valid until countersigned by the Registrar.

| 2 | To be included if the certificate is in global form, otherwise to be the name of the holder of the certificated 
 shares.                                                                                                         |

IN WITNESS WHEREOF, the Corporation has caused this certificate to be executed. Comerica Incorporated

| By:    |     |                                                             |
| Name:  |     | James J. Herzog                                             |
| Title: |     | Senior Executive Vice President and Chief Financial Officer |

D-10

REGISTRAR’S COUNTERSIGNATURE This is one of the certificates representing shares of the 6.875% Fixed-Rate Reset Non-CumulativePerpetual Preferred Stock, Series B, referred to in the within mentioned Certificate of Designations.

| Computershare Trust Company, N.A. |
| By:                               |
| Name:                             |
| Title:                            |
| Dated:                            |

REVERSE OF SECURITY COMERICA INCORPORATED The shares of 6.875% Fixed-Rate Reset Non-CumulativePerpetual Preferred Stock, Series B (the “ Series B Preferred Stock”) have the preferences and privileges, dividend rights, liquidation preferences and such other rights and qualifications, limitations and restrictions as provided in the Certificate of Designations relating to the Series B Preferred Stock (the “ Certificate of Designations”), in addition to those set forth in the Restated Certificate of Incorporation of the Corporation, as amended (the “ Certificate of Incorporation”), and the Corporation’s Amended and Restated Bylaws, copies of which shall be furnished by the Corporation to any holder without charge upon the request addressed to the Secretary of the Corporation at its principal office in Dallas, Texas or to the Registrar named on the face of this certificate. A statement of the rights, preferences, privileges and restrictions granted to or imposed upon the respective classes or series of stock of the Corporation, and upon the holders thereof as established by the Certificate of Incorporation, the Certificate of Designations or any other certificate of determination of preferences, and the number of shares constituting each series or class and the designations thereof, may be obtained by any stockholder of the Corporation upon request and without charge from the Secretary of the Corporation at the principal office of the Corporation, Comerica Bank Tower, 1717 Main Street, MC 6404,