Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 91

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 91
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 for a period of less than five years and who disposes of his or her Warrants/Pre-Funded Warrants and/or ADSs during that period of temporary non-residence may be liable to U.K. capital gains tax on a chargeable gain accruing on such disposal
on his or her return to the United Kingdom (or upon ceasing to be regarded as resident outside the United Kingdom for the purposes of double taxation relief) (subject to available exemptions or reliefs).

Non-UnitedKingdom Holders. The paragraphs below relating to the liability of non-U.K. Holders to U.K. tax on chargeable gains assume that the company does not (and will not) derive 75% or more of its gross asset value from U.K. land.

An individual holder who is not a U.K. Holder will not be liable to U.K. capital gains tax on capital gains realized on the disposal of his or
her Warrants/Pre-Funded Warrants and/or ADSs unless such holder carries on (whether solely or in partnership) a trade, profession or vocation in the United Kingdom through a permanent establishment in the
United Kingdom to which the Warrants/Pre-Funded Warrants and/or ADSs are attributable. In these circumstances, such holder may, depending on his or her individual circumstances, be chargeable to U.K. capital
gains tax on chargeable gains arising from a disposal of his or her ADSs.

A corporate holder of
Warrants/Pre-Funded Warrants and/or ADSs that is not a U.K. Holder will not be liable for U.K. corporation tax on chargeable gains realized on the disposal of its
Warrants/Pre-Funded Warrants and/or ADSs unless it carries on a trade in the United Kingdom through a permanent establishment to which the Warrants/Pre-Funded Warrants
and/or ADSs are attributable. In these circumstances, a disposal of Warrants/Pre-Funded Warrants and/or ADSs by such holder may give rise to a chargeable gain or an allowable loss for the purposes of U.K.
corporation tax.

Stamp Duty and Stamp Duty Reserve Tax

The statements below in relation to U.K. stamp duty and stamp duty reserve tax, or SDRT, apply irrespective of whether the relevant holder of Warrants/Pre-Funded Warrants and/or ADSs is resident in the United Kingdom.

Issue and Transfer of Ordinary Shares

Issue (including to a depositary or clearance service). No U.K. stamp duty