Company: ACHV
Filing Date: 2025-01-10
Form Type: S-8
Source: 0000950170-25-004143
Chunk: 5

Company: ACHIEVE LIFE SCIENCES, INC.
Filing Date: 2025-01-10
Form: S-8
Chunk 5
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) is asserted by such director, officer or controlling person in connection with the securities being registered hereby, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

<div align='center'>SIGNATURES</div>

Pursuant to the requirements of the Securities Act, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Seattle, Washington, on this 10th day of January, 2025.

| ACHIEVE LIFE SCIENCES, INC. |     |                                 |
| By:                         |     | /s/ Mark Oki                    |
|                             |     | Mark OkiChief Financial Officer |

<div align='center'>POWER OF ATTORNEY</div>

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Richard Stewart and Mark Oki, and each of them, as his true and lawful attorney-in-fact and agent with full power of substitution, for him in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

| Name                               
 /s/ Richard StewartRichard Stewart 
 /s/ Mark OkiMark Oki               |     | Title                                                                  
 Chief Executive Officer and Director(Principal Executive Officer)      
 Chief Financial Officer(Principal Financial Officer)                   |     | Date             
 January 10, 2025 
 January 10,