Company: CERO
Filing Date: 2025-06-06
Form Type: 424B3
Source: 0001213900-25-052185
Chunk: 5

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-06-06
Form: 424B3
Chunk 5
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 2025 |
|:------------|:----|:-----------------------------------------------------------------------------------------------------------------------|
| 104         |     | Cover Page Interactive Data File (embedded within the Inline XBRL document)                                            |

| * | Filed herewith.                                     |
| + | Indicates management contract or compensatory plan. |

<div align='center'>2

SIGNATURES</div>

Pursuant to the requirements of the Securities
Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

| Date: June 2, 2025 | cERO THERAPEUTICS HOLDINGS, Inc. |                         |
|:-------------------|:---------------------------------|:------------------------|
|                    | By:                              | /s/ Chris Ehrlich       |
|                    | Name:                            | Chris Ehrlich           |
|                    | Title:                           | Chief Executive Officer |

<div align='center'>3

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): June 5, 2025

CERO THERAPEUTICS HOLDINGS, INC.

(Exact name of Registrant as Specified in Its Charter)</div>

| Delaware                     |     | 001-40877   |     | 81-4182129         |
| (State or Other Jurisdiction 
 of Incorporation)            |     | -Commission 
 File Number |     | -IRS Employer      
 Identification No. |

| 201 Haskins Way, Suite 230               |     |           |
| South San Francisco, California          |     |     94080 |
| (Address of Principal Executive Offices) |     | -Zip Code |

<div align='center'>Registrant’s Telephone Number, Including Area Code: 650-407-2376

(Former Name or Former Address, if Changed Since Last Report)</div>

Check the appropriate box below if the Form 8-K filing is intended to simultaneously
satisfy the filing obligation of the registrant under any of the following provisions:

| ☐ | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |

| ☐ | Soliciting material pursuant to Rule 14a-12 under the Exchange