Company: SNY
Filing Date: 2025-10-27
Form Type: 424B5
Source: 0001193125-25-250786
Chunk: 17

Company: Sanofi
Filing Date: 2025-10-27
Form: 424B5
Chunk 17
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 Law | New York. |

| Use of Proceeds | The net proceeds of the offering, after deduction of underwriting discounts and commissions and expenses, amount to approximately $   . |

| We intend to use the net proceeds for general corporate purposes. |

S-14

RISK FACTORS We urge you to carefully review the risks described below, together with the risks described in the documents incorporated by reference into this prospectus supplement and the attached prospectus to the extent supplemented or superseded by the risks described below before you decide to purchase the notes. In particular, you should review the risks relating to our business included in our 2024 Form 20-F,incorporated by reference herein, and any similar disclosure in any subsequent report. If any of these risks actually occur, our business, financial condition and results of operations could suffer, and the trading price and liquidity of the notes offered by this prospectus supplement and the attached prospectus could decline, in which case you may lose all or part of your investment. Risks relating to an investment in the notes We may incur substantially more debt in the future. We may incur substantial additional indebtedness in the future, including in connection with future acquisitions, some of which may be secured by our assets. The terms of the notes issuable hereunder and the indenture under which the notes are issued will not limit the amount of indebtedness we may incur. Any such incurrence of additional indebtedness could exacerbate the risks that holders of the notes currently face. At any point in time there may or may not be an active trading market for our notes. At any point in time there may or may not be an active trading market for our notes. We have not listed and do not intend to list the notes on any securities exchange or automated quotation system. In addition, underwriters, broker-dealers and agents that participate in the distribution of the notes may make a market in the notes as permitted by applicable laws and regulations but will have no obligation to do so, and any such market-making activities with respect to the notes may be discontinued at any time without notice. If any of the notes are traded after their initial issuance, they may trade at a discount from their initial offering price. Factors that could cause the notes to trade at a discount include, among others:

| • |     | an increase in prevailing interest rates; |

| • |     | a decline in our credit worthiness; |

| • |     | the time remaining to the maturity; |

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