Company: RGNX
Filing Date: 2025-06-23
Form Type: CORRESP
Source: 0001193125-25-144857
Chunk: 0

Company: REGENXBIO Inc.
Filing Date: 2025-06-23
Form: CORRESP
Chunk 0
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June 23, 2025 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549

| Attn: | Doris Stacey Gama |

| Re: | REGENXBIO Inc. (the “Company”) |

| Registration Statement Filed on Form S-3 (the “Registration 
 Statement”)                                                 |

| File No. 333-288053 |

Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933, as amended, the Company hereby respectfully requests that the effective date for the above-referenced Registration Statement be accelerated to 4:00 p.m., Eastern Time, on June 25, 2025, or as soon as practicable thereafter. Please contact Matthew C. Franker of Covington & Burling LLP at (202) 662-5895or mfranker@cov.com with any questions you may have regarding this request. In addition, please notify Mr. Franker by telephone when this request for acceleration has been granted.

| Respectfully,  |     |                                       |
| REGENXBIO Inc. |     |                                       |
| By:            |     | /s/ Patrick Christmas                 |
| Name:          |     | Patrick Christmas                     |
| Title:         |     | Executive Vice President, Chief Legal 
 Officer                               |

| cc: | Matthew C. Franker, Covington & Burling LLP |