Company: AZN
Filing Date: 2025-06-26
Form Type: 11-K
Source: 0001683168-25-004771
Chunk: 2

Company: ASTRAZENECA PLC
Filing Date: 2025-06-26
Form: 11-K
Chunk 2
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 error or fraud.

Our audits included performing
procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures
that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the
financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management,
as ,veil as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for
our opinion.

Supplemental Information

The supplemental Schedule H, line
4i - Schedule of Assets (Held at End of Year) as of December 31, 2024 has been subjected to audit procedures performed in conjunction
with the audit of the Plan’s financial statements. The supplemental schedule is the responsibility of the Plan’s management. Our audit
procedures included determining whether the supplemental schedule reconciles to the financial statements or the underlying accounting
and other records, as applicable, and performing procedures to test the completeness and accuracy of the information presented in the
supplemental schedule. In forming our opinion on the supplemental schedule, we evaluated whether the supplemental schedule, including
its form and content, is presented in conformity with the Department of Labor’s Rules and Regulations for Reporting and Disclosure under
the Employee Retirement Income Security Act of 1974. In our opinion, the supplemental schedule is fairly stated, in all material respects,
in relation to the financial statements as a whole.

/s/ PricewaterhouseCoopers
LLP

New York, NY

June 24, 2025

We have served as the Plan’s auditor since 2018.

PricewaterhouseCoopers
LLP, 300 Madison Avenue, New York, New York 10017

T: (646) 4713000, www.pwc.com/us

| 3 |

<div align='center'>ASTRAZENECA SAVINGS AND SECURITY PLAN

Statements of Net Assets Available for Benefits

December 31, 2024 and 2023

____________</div>

| ASSETS                                                                          
 Investments:                                                                    |     | 2024 |               |     | 2023 |               |
|:--------------------------------------------------------------------------------|:----|:-----|--------------:|:----|:-----|--------------:|
| Investments at fair value                                                       |     | $    | 8,334,643,410 |     | $    | 7,250,832,374 |
| Investments in fully