Company: SHPH
Filing Date: 2025-03-05
Form Type: S-1/A
Source: 0001493152-25-009106
Chunk: 2

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-03-05
Form: S-1/A
Chunk 2
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000 Shares of Common Stock

Up to 10,000,000 Pre-Funded Warrants to Purchase up to 10,000,000 Shares of Common Stock

Up to 10,000,000 Shares of Common Stock Underlying the Pre-Funded Warrants</div>

This is a firm commitment underwritten offering
of up to 10,000,000 shares (the “Shares”) of common stock, par value $0.00001 per share (“common stock”)
or pre-funded warrants to purchase shares common stock in lieu thereof (the “Pre-Funded Warrants”).

The assumed public offering price for each share
of common stock or each Pre-Funded Warrant is $0.60, which is the last reported sale price per share of our common stock on the
Nasdaq Capital Market, or the Nasdaq, on February 26, 2025. The final public offering price per share or per Pre-Funded Warrant
will be determined through negotiation between us and the Underwriter (as defined hereinafter) based upon a number of factors, including
our history and our prospects, the industry in which we operate and other market conditions at the time of pricing and may be at a discount
to the then current market price of our common stock. Therefore, the recent market price of our common stock referenced throughout this
prospectus may not be indicative of the final offering price per share.

We are offering Pre-Funded Warrants to certain purchasers whose purchase of shares of common stock in this offering would otherwise result in the purchaser, together with its affiliates and certain related parties, beneficially owning more than 4.99% (or, at the election of the purchaser, 9.99%) of our outstanding common stock immediately following the consummation of this offering, the opportunity to purchase, if any such purchaser so chooses, Pre-Funded Warrants, in lieu of shares of common stock. The public offering price of each Pre-Funded Warrant will be equal to the price at which one share of common stock is sold to the public in this offering, minus $0.001, and the exercise price of each Pre-Funded Warrant will be $0.001 per share. The Pre-Funded Warrants will be immediately exercisable and may be exercised at any time until all of the Pre-Funded Warrants are exercised in full. For each Pre-Funded Warrant we sell, the number of shares of common stock we are offering will be decreased on a one