Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 17

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 17
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isable at any time beginning on the Initial Exercise Date and will expire on the two and one-half (2.5)-year anniversary of the Initial Exercise Date.                   |

| This prospectus also relates to the offering of the ADSs issuable upon exercise of the Series B Warrants. Because we will issue a Series B Warrant for each ADS and for each 
 Pre-Funded Warrant sold in this offering, the number of Series B Warrants sold in this offering will not change as a result of a change in the mix of the ADSs and           
 Pre-Funded Warrants sold.                                                                                                                                                    |

| To better understand the terms of the Series B Warrants, including the cashless exercise option and “zero exercise price” option, you should carefully read the “Description of Securities We Are 
 Offering” section of this prospectus.                                                                                                                                                             |

| ADSs outstanding prior to this offering | 5,737,172 ADSs, each representing twenty-five ordinary shares. |

| ADSs outstanding after this offering | 18,234,940 ADSs, each representing twenty-five ordinary shares, assuming no Pre-Funded Warrants are issued and no Warrants are exercised. |

| Ordinary shares to be outstanding immediately after this offering | 464,338,974 ordinary shares (including those ordinary shares represented by ADSs), assuming no Pre-Funded Warrants are issued and no Warrants are exercised. |

| ADSs | Each ADS represents twenty-five ordinary shares, nominal value £0.0004 per ordinary share. |

| The depositary or its custodian, or a nominee of either, will hold the ordinary shares underlying your ADSs. As an ADS holder you will not be treated as one of our shareholders and you will not have shareholder rights.                        
 You will have rights as provided in the deposit agreement, as amended, or the deposit agreement. You may cancel your ADSs and withdraw the underlying ordinary shares as provided in the deposit agreement. We may amend or terminate the deposit 
 agreement without your consent. If you continue to hold your ADSs following an amendment, you agree to be bound by the terms of the deposit agreement then in effect.                                                                             |

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| Depositary | Citibank, N.A., or Citibank. |

| Shareholder approvals required for offering | Under English law, certain steps necessary for the completion of this offering require the approval of our shareholders by way of an ordinary resolution and a special resolution. We will receive all such required approvals prior to the 
 completion of this offering.