Company: SCLXW
Filing Date: 2025-11-24
Form Type: 424B3
Source: 0001193125-25-293873
Chunk: 11

Company: Scilex Holding Co
Filing Date: 2025-11-24
Form: 424B3
Chunk 11
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 on the date following the date hereof, the Company shall issue a press release disclosing the material terms of the transactions contemplated hereby
or, within the time required by the Exchange Act, file a Current Report on Form 8-K with the Commission disclosing all material terms of the transactions contemplated hereunder, including the filing with the
Commission of this letter agreement as an exhibit thereto. From and after the dissemination of such press release or Form 8-K, the Company represents to you that it shall have publicly disclosed all material, non-public information delivered to you by the Company, or any of its respective officers, directors, employees or agents in connection with the transactions contemplated hereunder. In addition, effective upon the
dissemination of such press release or Form 8-K, the Company acknowledges and agrees that any and all confidentiality or similar obligations under any agreement, whether written or oral, between the Company,
any of its Subsidiaries or any of their respective officers, directors, agents, employees or Affiliates on the one hand, and you and your Affiliates on the other hand, shall terminate. The Company represents, warrants and covenants that, upon
acceptance of this offer, the Warrant Shares shall be issued free of any legends or restrictions on resale by Holder.

No
later than the first (1) Trading Day following the date hereof, the closing (“”) shall occur at such location as the parties shall mutually agree. Unless otherwise
directed by Rodman & Renshaw LLC (the “”), settlement of the Warrant Shares shall occur via “Delivery Versus Payment” (“”) (i.e., on the Closing Date (as defined below),
the Company shall issue the Warrant Shares registered in the Holder’s name and address provided to the Company in writing and released by the Transfer Agent directly to the account(s) at the Placement Agent identified by the Holder; upon
receipt of such Warrant Shares, the Placement Agent shall promptly electronically deliver such Warrant Shares to the Holder, and payment therefor shall concurrently be made to the Company by the Placement Agent (or its clearing firm) by wire
transfer to the Company). The date of the Closing of the Warrant Exercise shall be referred to as the “”.

| Sincerely yours,       |     |                                       |
| SCILEX HOLDING COMPANY |     |                                       |
| By:                    |     | /s/ Henry Ji, Ph.D.                   |
| Name:                  |     | Henry Ji, Ph.D.