Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 10

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 10
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 Form 10-Kfor the year ended December 31, 2024 and the other documents we incorporate by reference, before you determine whether an investment in the depositary shares is appropriate for you. About Comerica Incorporated Comerica is a financial services company, incorporated under the laws of the State of Delaware in 1973, and headquartered in Dallas, Texas. Based on total assets, as of June 30, 2025, it was among the 25 largest commercial United States financial holding companies. As of June 30, 2025, Comerica owned directly or indirectly all the outstanding common stock of two active banking subsidiaries (Comerica Bank, a Texas banking association, and Comerica Bank & Trust, National Association) as well as non-bankingsubsidiaries. At June 30, 2025, Comerica had total assets of approximately $78.0 billion, total deposits of approximately $60.0 billion, total loans of approximately $51.2 billion and shareholders’ equity of approximately $6.9 billion. Comerica has strategically aligned its operations into three major business segments: the Commercial Bank, the Retail Bank, and Wealth Management. In addition to the three major business segments, the Finance and Other categories include items not directly associated with the business segments.

| • |     | The Commercial Bank meets the needs of small and middle market businesses, multinational corporations and                                                                                                                                                
 governmental entities by offering various products and services including commercial loans and lines of credit, deposits, cash management, payment solutions, card services, capital market products, international trade finance and letters of credit. |

| • |     | The Retail Bank includes a full range of personal financial services, consisting of consumer lending, consumer                                                                                                                                           
 deposit gathering and mortgage loan origination. This business segment offers a variety of consumer products, including deposit accounts, installment loans, credit cards, home equity lines of credit and residential mortgage loans. In addition, this 
 business segment offers products and services to small businesses who are serviced through a team of dedicated small business bankers and our branch network.                                                                                            |

| • |     | Wealth Management provides products and services to affluent,                                                                                                                        
 high-net worth and ultra-high-net-worth individuals and families, business owners and executives, and institutional clients,                                                         
 including comprehensive financial planning, trust and fiduciary services, investment management and advisory, brokerage, private banking, and business transition planning services. |

Comerica operates in five primary geographic markets — Texas, California, Michigan