Company: CSTL
Filing Date: 2025-04-09
Form Type: DEF 14A
Source: 0001447362-25-000054
Chunk: 56

Company: CASTLE BIOSCIENCES INC
Filing Date: 2025-04-09
Form: DEF 14A
Chunk 56
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 with revenues of approximately three-fourths (0.75x) to five times (5x) our then-projected revenue (when rounded, this resulted in a range of $150 million to $1.02 billion in revenue); and

#### Castle Biosciences 2025 Proxy Statement55

#### Compensation Discussion and Analysis
• with market value of approximately one-half (0.5x) to four times (4x) our market capitalization at the time (resulting in a range of between $200 million to $1.7 billion in market capitalization).

The 2024 Peer Group consists of the 17 companies listed in the table below. At the time the Compensation Committee approved the 2024 Peer Group, we were at approximately the 13th percentile for market capitalization among the 2024 Peer Group, approximately the 28th percentile for revenue and approximately the 79th percentile for annual revenue growth. The Compensation Committee considered this a reasonable balance and a good representation of companies that were of similar scope and complexity that are aligned with the potential growth of the Company.

The companies comprising the 2024 Peer Group selected by Aon and approved by the Compensation Committee are listed below:

| uAdaptive Biotechnologies Corporation (ADPT) |     | uCareDx, Inc. (CDNA)               |     | uMesa Laboratories, Inc. (MLAB)    |     | uPacific Biosciences of California, Inc. (PACB) |     | uVeracyte, Inc. (VCYT) |
| uADMA Biologics, Inc. (ADMA)                 |     | uGuardant Health, Inc. (GH)        |     | uNatera, Inc. (NTRA)               |     | uQuanterix Corporation (QTRX)                   |     |                        |
| uAxonics, Inc. (AXNX)                        |     | uInvitae Corporation (NVTAQ)       |     | uNeoGenomics, Inc. (NEO)           |     | uSilk Road Medical, Inc. (SILK)                 |     |                        |
| uBioCryst Pharmaceuticals, Inc. (BCRX)       |     | uiRhythm Technologies, Inc. (IRTC) |     | uOraSure Technologies, Inc. (OSUR) |     | uTwist Bioscience Corporation (TWST)            |     |                        |

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