Company: TELO
Filing Date: 2025-02-04
Form Type: 10-K
Source: 0001493152-25-004872
Chunk: 274

Company: Telomir Pharmaceuticals, Inc.
Filing Date: 2025-02-04
Form: 10-K
Item: Item 1
Chunk 274
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Overview

Telomir-1 is a novel oral small molecule metal
ion regulator designed to extend telomere caps, maintain cellular balance, and combat oxidative stress, a key driver of aging and disease
progression. By modulating essential metal ions such as iron, and copper, Telomir-1 may help protect against age-related conditions,
including Progeria (a rare genetic disorder that causes rapid aging in children), Wilson’s disease (a genetic disorder leading to
toxic copper buildup in the body), and Age-related Macular Degeneration (AMD), as well as Type 2 Diabetes, cancer, and Alzheimer’s
disease.

Oxidative stress also
plays a critical role in the propagation and severity of viral infections like bird flu, where the virus triggers an imbalance between increased production of reactive oxygen species (ROS) and reduced antioxidant
host responses that leads to increased redox stress, a process which ultimately excessive weakens
immune defenses, increases inflammation, and enables enhanced viral replication. By reversing oxidative stress, Telomir-1 may help
strengthen immune resilience and reduce disease severity, offering broad therapeutic potential across both age-related and
infectious diseases.

Telomeres
are repetitive DNA sequences at the end of chromosomes that protect the chromosomes from becoming frayed or tangled. Each time a cell
divides, the telomeres become slightly shorter, and eventually they become so short that the cell can no longer divide, with the result
being that the cell dies. Effectively, telomeres protect the ends of our chromosomes by forming a cap, much like the plastic tip on shoelaces,
thereby allowing the chromosome to be replaced properly during cell division. If demonstrated by future clinical trials and approved
by the U.S. Food and Drug Administration, or FDA, we believe Telomir-1 may protect variable cells by elongating and stimulating the telomeres
to sustain self-renewal and longevity.

Based on our preclinical studies, we have
gathered experimental evidence suggesting that Telomir-1 may act as a regulator of essential metal ions such as iron, zinc, and copper.
While these trace elements are critical for various physiological functions, imbalances—whether due to excess or deficiency—can
drive oxidative stress, leading to cellular damage, telomere shortening, and accelerated aging. This oxidative burden is also linked to
age-related conditions and certain cancers.

We believe Telomir-1 has the potential to protect cells in situ by mitigating