Company: CERO
Filing Date: 2025-01-07
Form Type: 424B3
Source: 0001213900-25-001661
Chunk: 1

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-01-07
Form: 424B3
Chunk 1
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 you should rely on this Prospectus Supplement.

Our common stock and public warrants are listed on Nasdaq Global Market
and Nasdaq Capital Market (collectively, “Nasdaq”) under the symbols “CERO” and “CEROW,” respectively.
On January 3, 2025, the last quoted sale price of our common stock as reported on Nasdaq was $0.0582 per share and the last quoted sale
price of our public warrants as reported on Nasdaq was $0.009 per warrant.

We are an “emerging growth company” under applicable federal securities laws and will be subject to reduced public company reporting requirements.

Investing in our securities involves a high degree of risk. Before buying any securities, you should carefully read the discussion of the risks of investing in our securities in “Risk Factors” beginning on page 31 of the Prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the securities to be issued under the Prospectus or determined if the Prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this Prospectus Supplement is January 7, 2025.

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or Section 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): December 2, 2024

CERO THERAPEUTICS HOLDINGS, INC.

(Exact name of registrant as specified in its charter)</div>

| Delaware                        |     | 001-40877               |     | 87-1088814            |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -Commission File Number |     | -I.R.S. Employer      
 Identification Number |

| 201 Haskins Way, Suite 230, South San Francisco, CA |     |     94080 |
| (Address of principal executive offices)            |     | -Zip Code |

<div align='center'>(650) 407-2376

Registrant’s telephone number, including area code

Not Applicable

(Former name or former address, if changed since last report)</div>

Check the appropriate box below if the Form 8-K
filing is intended to simultaneously satisfy the filing obligation of the registrant under any of