Company: ZLAB
Filing Date: 2025-04-18
Form Type: CORRESP
Source: 0001628280-25-018396
Chunk: 4

Company: Zai Lab Ltd
Filing Date: 2025-04-18
Form: CORRESP
Chunk 4
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 required under the CSRC, the CAC, and other governmental agencies; an affirmative statement that no application for any such material license or permit has been denied; and the consequences to the Company and its investors if the Company and its subsidiaries do not receive or maintain such permissions or approvals or inadvertently conclude that such permissions or approvals are not required, or if applicable laws, regulations, or interpretations change and the Company is required to obtain such permissions or approvals in the future.

Page 5

Nonetheless, the Company respectfully submits that it will make the following updates in its future disclosures on Form 10-K (together with such additional updates that the Company deems appropriate due to the passage of time or changing circumstances):

We are required to obtain certain approvals and licenses from Chinese authorities to operate our Chinese subsidiaries.

The Chinese government has exercised, and may continue to exercise, substantial influence or control over virtually every sector of the Chinese economy through regulation and state ownership. For example, to conduct our business activities in mainland China, each of our Chinese subsidiaries is required to obtain a business license from the local counterpart of the SAMR. Our ability to operate in mainland China could be undermined if our Chinese subsidiaries are not able to obtain or maintain required approvals from Chinese authorities to operate in mainland China. Each of our Chinese subsidiaries has obtained a valid business license from the local counterpart of the SAMR, and no application for any such license has been denied. The central or local governments could impose new, stricter regulations or interpretations of existing regulations that could require additional expenditures and efforts on our part to comply with such regulations or interpretations. If in the future our Chinese subsidiaries do not receive or maintain required approvals, such as because we inadvertently conclude that approvals are not required or because of changes in applicable laws and regulations or interpretations of such laws and regulations, the operations of our Chinese subsidiaries, and as a result our business, results of operations, financial condition, and prospects, could be adversely affected , and the value of our securities could significantly decline or become worthless .

Thank you for your consideration in reviewing the above responses. Please contact Sara von Althann of Sidley Austin LLP at (202) 736-8715 with any questions or further comments regarding the responses to the Staff’s comments.

Sincerely,

/s/ Sara von Althann

Sara von Althann

cc: Yajing Chen

Bruce Blefeld

Aslynn Hogue