Company: SHPH
Filing Date: 2025-01-22
Form Type: RW
Source: 0001493152-25-003122
Chunk: 0

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-01-22
Form: RW
Chunk 0
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<div align='center'>SHUTTLE PHARMACEUTICALS HOLDINGS, INC.

401 Professional Drive, Suite 260

Gaithersburg, MD 20879

(240) 430-4212</div>

January 21, 2025

Via EDGAR

Ms. Jessica Dickerson

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

| Re: | Shuttle                        
 Pharmaceuticals Holdings, Inc. |
|     | Registration                   
 Statement on Form S-1          |
|     | File                           
 No. 333-278535                 |

Dear Ms. Dickerson:

Pursuant to Rule 477 promulgated under the Securities Act of 1933, as amended, Shuttle Pharmaceuticals Holdings, Inc. (the “Company”) hereby respectfully requests that the Securities and Exchange Commission consent to the withdrawal of the Company’s registration statement on Form S-1 (File No. 333-278535), together with all exhibits thereto (collectively, the “Registration Statement”). The Registration Statement is not effective and no securities have been issued pursuant to the registration statement. We are withdrawing the registration statement because we have elected not to proceed with the form of offering set forth in the Registration Statement at this time. Accordingly, we respectfully request withdrawal of the Registration Statement as soon as reasonably practicable.

Please direct any comments or questions regarding this filing to our counsel, Megan J. Penick at Dorsey & Whitney LLP, who may be contacted at 212-415-9279 or penick.megan@dorsey.com.

| Very                           
 truly yours,                   |                                    |
| Shuttle                        
 Pharmaceuticals Holdings, Inc. |                                    |
| By:                            | /s/                                
 Anatoly Dritschilo                 |
| Name:                          | Anatoly                            
 Dritschilo                         |
| Title:                         | Chief                              
 Executive Officer and              
 Chairman of the Board of Directors |