Company: TVRD
Filing Date: 2025-11-13
Form Type: 424B3
Source: 0001104659-25-111336
Chunk: 204

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-11-13
Form: 424B3
Chunk 204
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 the Securities and
Exchange Commission on the date hereof (the "Report"), Imran Alibhai, Chief Executive Officer of the Company, and Dan Conn,
Chief Financial Officer of the Company, each hereby certifies, pursuant to the requirement set forth in Rule 13a-14(b) of the Securities
Exchange Act of 1934, as amended, (the “Exchange Act”) and Section 1350 of Chapter 63 of Title 18 of the United States Code
(18 U.S.C. §1350), that, to the best of his knowledge, based upon a review of the Report:

| (1) | The Report fully complies with the requirements of Section 13(a) or 15(d) of the Exchange Act; and |

| (2) | The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company. |

| ​                                  | ​ |
| /s/ IMRAN ALIBHAI                  | ​ |
| Name:   Imran Alibhai              | ​ |
| Title:     Chief Executive Officer 
 (Principal Executive Officer)      | ​ |
| Date:     November 13, 2025        | ​ |

​

| ​                                  | ​ |
| /s/ DAN CONN                       | ​ |
| Name:   Dan Conn                   | ​ |
| Title:     Chief Financial Officer 
 (Principal Financial Officer)      | ​ |
| Date: November 13, 2025            
 ​                                  
 ​                                  | ​ |
| ​                                  | ​ |

This certification accompanies the Form 10-Q to which
it relates, is not deemed filed with the Securities and Exchange Commission and is not to be incorporated by reference into any filing
of Tvardi Therapeutics, Inc. under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended (whether
made before or after the date of the Form 10-Q), irrespective of any general incorporation language contained in such filing.