Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063899
Chunk: 0

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 0
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<div align='center'>As confidentially submitted to the Securities and Exchange Commission on July 14, 2025

This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains strictly confidential</div>

Registration No. [ ]

<div align='center'>UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM F-1

REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

APTORUM GROUP LIMITED

(Exact Name of Registrant as Specified in its Charter)</div>

| Cayman Islands                  |     |                         2834 |     | Not Applicable     |
| (State or Other Jurisdiction of 
 Incorporation or Organization)  |     | -Primary Standard Industrial 
   Classification Code Number |     | -I.R.S. Employer   
 Identification No. |

<div align='center'>17 Hanover Square

London W1S 1BN, United Kingdom

Telephone: +44 20 80929299

(Address, including zip code, and telephone number, including area code, of Registrant’s principal executive offices)

Copies to:</div>

| Louis Taubman, Esq.             | Jonathan Deblinger, Esq.       
 John                           
 J. Hart, Esq.                  |
| Hunter Taubman Fischer & Li LLC | Ellenoff Grossman & Schole LLP |
| 950 Third Avenue, 19th Floor    | 1345 Avenue of the Americas    |
| New York, NY 10022              | New York, NY 10105-0302        |
| Tel: 917.512.0827               | Tel: (212) 370-1300            |
| Fax: 212.202.6380               |                                |

Approximate date of commencement of proposed sale to the public: As soon as practicable after effectiveness of this registration statement.

If any of the securities being registered on this
Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box.
☒

If this Form is filed to register additional securities
for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement
number of the earlier effective registration statement for the same offering. ☐

If this Form is a post-effective amendment filed
pursuant to Rule 462(c)