Company: APM
Filing Date: 2025-10-06
Form Type: S-4
Source: 0001213900-25-096656
Chunk: 368

Company: Aptorum Group Ltd
Filing Date: 2025-10-06
Form: S-4
Chunk 368
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 can be reliably and consistently detected in human plasma 210 samples with the methods implemented at DiamiR CLIA laboratory. While stem -loop-basedTaqMan and locked nucleic acid (LNA) -basedqPCR assays are shown to produce highly consistent results, Qiagen’s LNA -basedqPCR technology is better suited for a CAP/CLIA -certifiedclinical laboratory. (Diagnostics, 2023, 13:2170; Rett Syndrome Foundation Research Trust Conference, 2023, Boston MA, poster presentation; Alzheimer’s Association International Conference 2023, Amsterdam, Netherlands, poster presentation). Publications and Presentations During the last 12 years DiamiR has published a number of peer -reviewedpapers describing its technology for identification of miRNA biomarker pairs (the contents of these publications are not part of, and are not incorporated by reference into, this proxy statement/prospectus): 1.Analytical Validation of a Novel MicroRNA Panel for Risk Stratification of Cognitive Impairment. Arzu Kunwar, Kenny Kwabena Ablordeppey, Alidad Mireskandari, Kira Sheinerman, Michael Kiefer, Samuil Umansky and Gyanendra Kumar. Diagnostics 2023,13, 2170. https://doi.org/10.3390/ diagnostics13132170 2.Evaluation of long -termCOVID -19. Michael C. Kiefer and Samuil R. Umansky. Aging (Albany NY), 13(12): 15691 – 15693 (2021) 3.Brain -enrichedmicroRNAs circulating in plasma as novel biomarkers for Rett syndrome .Kira Sheinerman, Aleksandra Djukic, Vladimir G. Tsivinsky, and Samuil R. Umansky. PLOS ONE 14(7): e0218623 (2019) 4.Aging and aging -associateddiseases: a microRNA -basedendocrine regulation hypothesis .Samuil Umansky. Aging, Theory, 10(10): 2557 -2569(2018) 5.Age- and sex -dependentchanges in levels of circulating brain -enrichedmicroRNAs during normal aging .Kira Sheinerman, Vladimir Tsivinsky, Aabhas Mathur, Debra Kessler, Beth Shaz and Samuil Umansky. Aging, Research, 10(10):