Company: SRPT
Filing Date: 2025-03-03
Form Type: S-3ASR
Source: 0001193125-25-044088
Chunk: 17

Company: Sarepta Therapeutics, Inc.
Filing Date: 2025-03-03
Form: S-3ASR
Chunk 17
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 or the trustee of a new certificate to the new holder. Global Debt Securities and Book-Entry System.Each global debt security representing book-entry debt securities will be deposited with, or on behalf of, the Depositary, and registered in the name of the Depositary or a nominee of the Depositary. Please see “Global Securities.” 11

Global Securities The debt securities of any series may be represented, in whole or in part, by one or more global securities. Each global security will:

| • |     | be registered in the name of a depositary, or its nominee, that we will identify in a prospectus supplement; |

| • |     | be deposited with the depositary or nominee or custodian; and |

| • |     | bear any required legends. |

No global security may be exchanged in whole or in part for debt securities registered in the name of any person other than the depositary or any nominee unless:

| • |     | the depositary has notified us that it is unwilling or unable to continue as depositary or has ceased to be 
 qualified to act as depositary;                                                                             |

| • |     | an event of default is continuing with respect to the debt securities of the applicable series; or |

| • |     | any other circumstance described in a prospectus supplement has occurred permitting or requiring the issuance of 
 any such security.                                                                                               |

As long as the depositary, or its nominee, is the registered owner of a global security, the depositary or nominee will be considered the sole owner and holder of the debt securities represented by the global security for all purposes under the indentures. Except in the above limited circumstances, owners of beneficial interests in a global security will not be:

| • |     | entitled to have the debt securities registered in their names; |

| • |     | entitled to physical delivery of certificated debt securities; or |

| • |     | considered to be holders of those debt securities under the indenture. |

Payments on a global security will be made to the depositary or its nominee as the holder of the global security. Some jurisdictions have laws that require that certain purchasers of securities take physical delivery of such securities in definitive form. These laws may impair the ability to transfer beneficial interests in a global security. Institutions that have accounts with the depositary or its nominee are referred to as “participants.” Ownership of beneficial interests in a global security will be limited to participants and to persons that may hold beneficial interests through participants. The depositary will credit,