Company: PSTV
Filing Date: 2025-08-22
Form Type: S-8
Source: 0001193125-25-186490
Chunk: 3

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-08-22
Form: S-8
Chunk 3
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 the Commission of this Registration Statement under the Securities Act, including specifically but without limitation, power and authority to sign the name of the undersigned to such Registration Statement, and any amendments to such Registration Statement (including post-effective amendments), and to file the same with all exhibits thereto and other documents in connection therewith, with the Commission and any applicable securities exchange or securities regulatory body, to sign any and all applications, registration statements, notices or other documents necessary or advisable to comply with applicable securities laws, including without limitation state securities laws, and to file the same, together with other documents in connection therewith with the appropriate authorities, including without limitation state securities authorities, granting unto said attorney-in-factand agent, full power and authority to do and to perform each and every act and thing requisite or necessary to be done in and about the premises, as fully and to all intents and purposes as the undersigned might or could do in person, hereby ratifying and confirming all that said attorney-in-factand agent, or his substitute, may lawfully do or cause to be done by virtue hereof. This Power of Attorney may be signed in several counterparts. Pursuant to the requirements of the Securities Act, this Registration Statement has been signed by the following persons in the capacities set forth below on August 22, 2025.

| Signature                      
 /S/ MARC H. HEDRICK, M.D.      
 MARC H. HEDRICK, M.D.          
 /S/ ANDREW SIMS                
 ANDREW SIMS                    |     | Title                                           
 President, Chief Executive Officer and Director 
 (Principal Executive Officer)                   
 Chief Financial Officer                         
 (Principal Financial and Accounting Officer)    |     | Date            
 August 22, 2025 
 August 22, 2025 |
|:-------------------------------|:----|:------------------------------------------------|:----|:----------------|
| /S/ RICHARD J. HAWKINS         
 RICHARD J. HAWKINS             |     | Chair of the Board of Directors                 |     | August 22, 2025 |
| /S/ HOWARD CLOWES              
 HOWARD CLOWES                  |     | Director                                        |     | August 22, 2025 |
| /S/ AN VAN ES-JOHANSSON,       
 M.D. AN VAN ES-JOHANSSON, M.D. |     | Director                                        |     | August 22, 2025 |
| /S/ ROBERT