Company: XXII
Filing Date: 2025-05-08
Form Type: S-3
Source: 0001641172-25-009301
Chunk: 3

Company: 22nd Century Group, Inc.
Filing Date: 2025-05-08
Form: S-3
Chunk 3
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 selling stockholders may sell their shares of common stock in the section titled “Plan of Distribution” beginning on page 11 of this prospectus. We will not be paying any underwriting discounts or commissions in connection with any offering of shares under this prospectus.

Our common stock is listed on the Nasdaq Capital market under the symbol “XXII.” On May 7, 2025, the closing price of our common stock was $1.25 per share.

Investment in our common stock involves risks. Please read carefully the section entitled “Risk Factors” on page 1 of this prospectus, our most recent Annual Report on Form 10-K, subsequently filed Quarterly Reports on Form 10-Q and in any applicable prospectus supplement and/or other offering material for a discussion of certain factors which should be considered in an investment of the common stock which may be offered hereby.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is , 2025.</div>

<div align='center'>TABLE OF CONTENTS</div>

| About This Prospectus                           | ii |
| 22nd Century Group, inc.                        |  1 |
| Use of Proceeds                                 |  1 |
| Risk Factors                                    |  1 |
| Description of Capital Stock                    |  2 |
| Selling Stockholders                            |  7 |
| Plan of Distribution                            |  9 |
| Legal Matters                                   | 11 |
| Experts                                         | 11 |
| Where You Can Find More Information             | 11 |
| Incorporation of Certain Documents by Reference | 11 |

| i |

<div align='center'>About This Prospectus</div>

Unless the context otherwise requires, references in this prospectus to “Company,” “22 ndCentury,” “we,” “us,” “our,” and “ours” refer to 22 ndCentury Group, Inc. and its subsidiaries where the context so requires.

This prospectus is part of a registration statement that we filed with the Securities and Exchange Commission, or SEC, using a “shelf” registration process. Under this shelf registration process, the selling stockholders may, from time to time, sell the shares of common stock described in this prospectus in one or more offerings. A prospectus supplement and/or other offering material may also add, update or change information contained in