Company: PSTV
Filing Date: 2025-08-12
Form Type: S-1
Source: 0001193125-25-178940
Chunk: 16

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-08-12
Form: S-1
Chunk 16
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 refusal, participation rights, penalties or liquidated damages in the Purchase Agreement or Registration Rights Agreement, other than a
prohibition on any “equity line of credit”, “at-the-market offering” or other similar continuous offering in which we may offer, issue or sell
shares of our common stock or securities convertible into shares of our common stock (or any combination of units thereof) at a future determined price, subject to customary exceptions. Lincoln Park may not assign or transfer its rights and
obligations under the Purchase Agreement.

As consideration for Lincoln Park’s commitment to purchase shares of our common stock
upon the terms of and subject to satisfaction of the conditions set forth in the Purchase Agreement, we intend to issue 1,612,903 shares of our common stock with a per share value of $0.31 as the Initial Commitment Shares. The Initial Commitment
Shares must be included in a registration statement to be filed with and declared effective by the SEC on or prior to the date the Initial Commitment Fee is due registering under the Securities Act the resale by Lincoln Park of such Initial
Commitment Shares. We have also agreed to pay an Additional Commitment Fee of $500,000, which we may elect to pay in cash, shares of our common stock or any combination thereof, upon our receipt of $25.0 million aggregate gross proceeds from
sales of common stock to Lincoln Park under the Purchase Agreement. Through August 8, 2025, approximately $2.8 million of common stock have been sold under the Prior Registration Statement. In the event that part or all of the Additional
Commitment Fee is paid in

8

Additional Commitment Shares, such Additional Commitment Shares must be included in a registration statement to be filed with and declared effective by the SEC on or prior to the date the
Additional Commitment Fee is due registering under the Securities Act the resale by Lincoln Park of such Additional Commitment Shares.

As
of August 8, 2025, there were 99,264,526 shares of our common stock outstanding, of which 98,785,360 shares of our common stock were held by non-affiliates. If all of the 33,000,000 shares offered by
Lincoln Park under this prospectus were issued and outstanding, such shares would represent approximately 25% of the total number of shares of our common stock outstanding and approximately 25.0% of the total number of outstanding shares held by non-affiliates, in each case as of August