Company: TVRD
Filing Date: 2025-10-20
Form Type: S-8
Source: 0001104659-25-100898
Chunk: 0

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-10-20
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on October 20, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

Tvardi Therapeutics, Inc.

(Exact name of registrant as specified in its charter)</div>

| Delaware                                 |     |         75-3175693 |
| (State or other jurisdiction of          
 incorporation or organization)           |     |   -I.R.S. Employer 
 Identification No. |
| 3 Sugar Creek Ctr. Blvd.                 
 Suite 525                                
 Sugar Land, Texas                        |     |              77478 |
| (Address of Principal Executive Offices) |     |          -Zip Code |

<div align='center'>2018 Stock Incentive Plan

2025 Equity Incentive Plan

2025 Employee Stock Purchase Plan

(Full titles of the plans)

Imran Alibhai, Ph.D.

President and Chief Executive Officer

3 Sugar Creek Ctr. Blvd., Suite 525

Sugar Land, Texas 77478

(713) 489-8654

(Name, address, including zip code, and telephone
number, including area code, of agent for service)

Copies to:</div>

| Divakar Gupta      
 Madison Jones      
 Cooley LLP         
 55 Hudson Yards    
 New York, NY 10001 
 (212) 479-6000     |

Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of
“large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth
company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer | ¨ | Accelerated Filer         | ¨ |
| Non-accelerated filer   | x | Smaller reporting company | x |
|                         |   | Emerging growth company   | ¨ |

If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant
to Section 7(a)(2)(B)