Company: TVRD
Filing Date: 2025-01-27
Form Type: S-4/A
Source: 0001104659-25-006050
Chunk: 890

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-01-27
Form: S-4/A
Chunk 890
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 Cara, $0.001 par value per share (Cara common stock) in the aggregate, based on a ratio calculated in accordance with the Merger Agreement (the Exchange Ratio) (ii) the outstanding Convertible Notes of Tvardi will be converted into shares of Cara common stock, pursuant to the terms of the Convertible Notes and assuming interest on the Convertible Notes is accrued through the anticipated Effective Time. At the Effective Time, subject to the terms and conditions of the Merger Agreement, Cara will assume outstanding and unexercised options to purchase shares of Tvardi common stock, and in connection with the Merger, they will be converted into options to purchase shares of Cara common stock based on the Exchange Ratio. As of the Effective Time, Cara’s stockholders will continue to own and hold their then existing shares of Cara common stock, subject to adjustment for a reverse stock split.The completion of the Merger is subject to customary closing conditions, including, among other things (i) approval by the stockholders of each party of the adoption and approval of the Merger Agreement and the transactions contemplated thereby, (ii) Nasdaq’s approval of the listing of shares of Cara common stock to be issued in connection with the Merger, (iii) the effectiveness of a registration statement filed with the SEC in connection with the Merger, and (iv) Cara net cash at the Effective Time of at least $18.0 million.​​​​

#### F-132

#### ANNEX AAGREEMENT AND PLAN OF MERGERAND REORGANIZATIONamong:CARA THERAPEUTICS, INC.a Delaware corporation;CT CONVERGENCE MERGER SUB, INC.,a Delaware corporation; andTVARDI THERAPEUTICS, INC.a Delaware corporationDated as of December 17, 2024​​
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TABLE OF CONTENTS

| ​                                                                  |                                                                 | ​ | Page |
| ​                                                                  |                                                                 | ​ | ​    |
| Section 1. DESCRIPTION OF TRANSACTION                              |                                                                 | ​ | A-2  |
| 1.1                                                                | The Merger                                                      | ​ | A-2  |
| 1.2                                                                | Effects of the Merger                                           | ​ | A-2  |
| 1.3                                                                | Closing; Effective Time                                         | ​ | A-2  |
| 1.4                                                                | Certificate of Incorporation and Bylaws; Directors and Officers | ​ | A-2  |
| 1.