Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 7

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 7
---
 then-outstanding SPAC Warrants approve of such amendment”.

Neither we nor the Selling Securityholders have authorized anyone to provide you with any information or to make any representations other
than those contained in this prospectus or any applicable prospectus supplement, any post-effective amendment or any free writing prospectuses prepared by or on behalf of us or to which we have referred you. Neither we nor the Selling
Securityholders take responsibility for, and can provide no assurance as to the reliability of, any other information that others may give you. Neither we nor the Selling Securityholders will make an offer to sell these securities in any
jurisdiction where the offer or sale is not permitted.

We may also provide a prospectus supplement or post-effective amendment to the
registration statement to add information to, or update or change information contained in, this prospectus. You should read both this prospectus and any applicable prospectus supplement or post-effective amendment to the registration statement
together with the additional information to which we refer you in the section of this prospectus titled “Where You Can Find More Information.”

On November 10, 2022, we consummated the Business Combination pursuant to the Merger Agreement, by and among us, Merger Sub and Legacy
Scilex. Pursuant to the terms of the Merger Agreement, we effected a deregistration under the Cayman Islands Companies Act (as revised) and a domestication under Section 388 of the Delaware General Corporation Law, as amended (the
“DGCL”), pursuant to which our jurisdiction of incorporation was changed from the Cayman Islands to the State of Delaware (the “Domestication”), and, on the terms and subject to the conditions set forth in the Merger Agreement
and in accordance with the DGCL, Merger Sub merged with and into Legacy Scilex (the “Merger”), with Legacy Scilex surviving as our wholly owned subsidiary. In connection with the Business Combination, we changed our name from Vickers
Vantage Corp. I to Scilex Holding Company.

Unless the context indicates otherwise, references in this prospectus to the
“Company,” “Scilex,” “we,” “us,” “our,” and similar terms refer to Scilex Holding Company, a Delaware corporation formerly known as Vickers Vantage Corp. I, and its consolidated subsidiaries.
References to “Legacy Scilex” refer to the private Delaware corporation that is now our wholly owned subsidiary, named Scilex, Inc. (formerly known as Scilex