Company: BDRX
Filing Date: 2025-11-24
Form Type: 424B3
Source: 0001214659-25-017136
Chunk: 78

Company: Biodexa Pharmaceuticals Plc
Filing Date: 2025-11-24
Form: 424B3
Chunk 78
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 mandatory provisions of applicable law.

Any amendments
or supplements that (i) are reasonably necessary (as agreed by us and the depositary) in order for (a) the Depositary Shares to be registered
on Form F-6 under the Securities Act or (b) the Depositary Shares or Ordinary Shares to be traded solely in electronic book-entry form
and (ii) do not in either such case impose or increase any fees or charges to be borne by ADR holders, shall be deemed not to prejudice
any substantial rights of ADR holders or beneficial owners. Notwithstanding the foregoing, if any governmental body or regulatory body
should adopt new laws, rules or regulations that would require amendment or supplement of the Deposit Agreement or the form of ADR to
ensure compliance therewith, we and the depositary may amend or supplement the Deposit Agreement and the form of ADR (and all outstanding
ADRs) at any time in accordance with such changed laws, rules or regulations. Such amendment or supplement to the Deposit Agreement in
such circumstances may become effective before a notice of such amendment or supplement is given to ADR holders or within any other period
of time as required for compliance.

| 43 |

Notice of any amendment to the Deposit
Agreement or form of ADRs shall not need to describe in detail the specific amendments effectuated thereby, and failure to describe the
specific amendments in any such notice shall not render such notice invalid, provided, however, that, in each such case, the notice given
to the ADR holders identifies a means for ADR holders and beneficial owners to retrieve or receive the text of such amendment (i.e.,upon retrieval from the SEC’s, the depositary’s or our website or upon request from the depositary).

How may the Deposit Agreement be terminated?

The depositary
may at any time, and shall at our written direction, terminate the Deposit Agreement and the ADRs by mailing notice of such termination
to the registered holders of ADRs at least thirty (30) days prior to the date fixed in such notice for such termination; provided, however,
if the depositary shall have (i) resigned as depositary under the Deposit Agreement, notice of such termination by the depositary shall
not be provided to registered ADR holders unless a successor depositary shall not be operating under the Deposit Agreement within sixty
(60) days of the date of such resignation, and (ii) been removed as depositary under the Deposit Agreement, notice of such termination