Company: SCLXW
Filing Date: 2025-07-23
Form Type: 424B3
Source: 0001193125-25-163077
Chunk: 246

Company: Scilex Holding Co
Filing Date: 2025-07-23
Form: 424B3
Chunk 246
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 evidenced thereby are hereby assigned to

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|                                |     | -Please Print |
| Address:                       |     |               |
|                                |     | -Please Print |
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| Email Address:                 |     |               |
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| Holder’s Signature:            |     |               |
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18

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 22, 2025 SCILEX HOLDING COMPANY (Exact name of registrant as specified in its charter)

| Delaware                     |     | 001-39852   |     | 92-1062542         |
| (State or other jurisdiction 
 of incorporation)            |     | -Commission 
 File Number |     | -IRS Employer      
 Identification No. |

960 San Antonio Road, Palo Alto, California, 94303 (Address of principal executive offices, including zip code) Registrant’s telephone number, including area code: (650) 516-4310 N/A (Former name or former address, if changed since last report) Check the appropriate box below if the Form 8-Kfiling is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

| ☐ | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |

| ☐ | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 
 CFR 240.14a-12)                                                        |

| ☐ | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |

| ☐ | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |

Securities registered pursuant to Section 12(b) of the Act

| Title of each class