Company: SHPH
Filing Date: 2025-08-05
Form Type: S-1
Source: 0001641172-25-022101
Chunk: 9

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-08-05
Form: S-1
Chunk 9
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ly owned by the selling stockholder, except as otherwise set forth in the footnotes to the table.

(2) Represents the amount of shares that will be held by the selling stockholder after completion of this offering based on the assumptions that (a) all shares of common stock offered for resale under this prospectus will be sold and (b) no other shares of common stock are acquired or sold by the selling stockholder prior to completion of this offering. However, the selling stockholder may sell all, some or none of such shares offered pursuant to this prospectus.

(3) Based on 1,070,773 shares of common stock outstanding as of August 1, 2025.

(4) Connor Yuen has voting and dispositive power over the shares. The address of the selling stockholder is 850 New Burton Road, Suite 201, Dover, DE 19904.

(5) Includes 1,158,953 shares issuable upon exercise of pre-funded warrants. The pre-funded warrants cannot be exercised to the extent such exercise would result in the holder beneficially owning more than 4.99% of the Company’s common stock. The ownership amount in the table does not give effect to such beneficial ownership limitation.

<div align='center'>PLAN OF DISTRIBUTION</div>

The selling stockholder and any of its pledgees, assignees and successors-in-interest may, from time to time, sell any or all of its securities covered hereby on the Nasdaq Capital Market or any other stock exchange, market or trading facility on which the securities are traded or in private transactions. These sales may be at fixed or negotiated prices. The selling stockholder may use any one or more of the following methods when selling securities:

| ● | ordinary                                                                                
 brokerage transactions and transactions in which the broker-dealer solicits purchasers; |

| ● | block                                                                                           
 trades in which the broker-dealer will attempt to sell the securities as agent but may position 
 and resell a portion of the block as principal to facilitate the transaction;                   |

| ● | purchases                                                                        
 by a broker-dealer as principal and resale by the broker-dealer for its account; |

| ● | an                                                                             
 exchange distribution in accordance with the rules of the applicable exchange; |

| ● | privately                
 negotiated transactions; |

| 7 |

| ● | settlement      
 of short sales; |

| ● | in                                                                                              
 transactions through broker-dealers that agree with the selling stockholder to sell a specified 
 number of such securities at a stip