Company: SCLXW
Filing Date: 2025-07-23
Form Type: 424B3
Source: 0001193125-25-163077
Chunk: 176

Company: Scilex Holding Co
Filing Date: 2025-07-23
Form: 424B3
Chunk 176
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 of this Agreement shall be, without any further action by the Holder or the Company,
automatically amended and modified in an economically and legally equivalent manner such that the Holder shall receive the benefit of the more favorable terms and/or conditions (as the case may be) set forth in such Specified Agreement, provided
that upon written notice to the Company at any time the Holder may elect not to accept the benefit of any such amended or modified term or condition, in which event the term or condition contained in this Agreement shall apply to the Holder as it
was in effect immediately prior to such amendment or modification as if such amendment or modification never occurred with respect to the Holder. The provisions of this shall apply similarly and equally to each
Specified Agreement.

(f) . The Company shall reimburse Kelley Drye & Warren, LLP (counsel to the lead
Holder) in an aggregate non-accountable amount of $50,000 (the “Legal Fee Amount”) for costs and expenses incurred by it in connection with drafting and negotiation of this Agreement. Each
party to this Agreement shall bear its own expenses in connection with the structuring, documentation, negotiation and closing of the transactions contemplated hereby, except as provided in the previous sentence and except that the Company shall be
responsible for the payment of any placement agent’s fees, financial advisory fees, transfer agent fees, Depository Trust Company fees relating to or arising out of the transactions contemplated hereby.

(g) . Article 9 of the Tranche B SPA (as amended hereby) is hereby incorporated by reference herein,
mutatis mutandis.

[Remainder of Page Intentionally Left Blank]

12

IN WITNESS WHEREOF, each of the undersigned have caused their respective signature page to this Agreement to be duly executed as of the date first written above.

| 3i, LP                     |     |                             |
| By:                        |     | /s/ Maier J. Tarlow         |
| Name:                      |     | Maier J. Tarlow             |
| Title:                     |     | Manager on Behalf of the GP |
| Address:                   |     |                             |
| 2 Wooster Street           |     |                             |
| 2nd Floor                  |     |                             |
| New York, NY 10013         |     |                             |
| Telephone: (646) 845-0040  |     |                             |
| Attention: Maier J. Tarlow |     |                             |
| Email:                     |     |                             |