Company: PRME
Filing Date: 2025-11-07
Form Type: S-3ASR
Source: 0001628280-25-050428
Chunk: 49

Company: Prime Medicine, Inc.
Filing Date: 2025-11-07
Form: S-3ASR
Chunk 49
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 page S- 11for additional information regarding the compensation to be paid to Jefferies. We have also agreed to provide indemnification and contribution to Jefferies against certain liabilities, including liabilities under the Securities Act and the Securities Exchange Act of 1934, as amended (the “Exchange Act”).

We are an “emerging growth company” and a “smaller reporting company” under the federal securities laws and, as such, we have elected to comply with certain reduced public company reporting requirements for this prospectus and for future filings. See “Prospectus Summary—Implications of Being an Emerging Growth Company and a Smaller Reporting Company.”

Investing in our common stock involves a high degree of risk. See “

#### Risk Factors
” beginning on page S- 4of this prospectus and under similar headings in the other documents that are incorporated by reference into this prospectus concerning factors you should consider before investing in our common stock.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities, or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

#### Jefferies

#### The date of this prospectus is November 7, 2025.

### TABLE OF CONTENTS
|                                                   |     | Page |
| About This Prospectus                             |     | S-ii |
| Special Note Regarding Forward-Looking Statements |     | S-iv |
| Prospectus Summary                                |     | S-1  |
| Risk Factors                                      |     | S-4  |
| Use of Proceeds                                   |     | S-7  |
| Dilution                                          |     | S-8  |
| Dividend Policy                                   |     | S-10 |
| Plan of Distribution                              |     | S-11 |
| Legal Matters                                     |     | S-12 |
| Experts                                           |     | S-12 |
| Where You Can Find More Information               |     | S-12 |
| Incorporation of Certain Information by Reference |     | S-13 |

We are responsible for the information contained and incorporated by reference in this prospectus, in any accompanying prospectus, and in any related free writing prospectus we prepare or authorize. We have not authorized anyone to give you any other information, and we take no responsibility for any other information that others may give you. If you are in a jurisdiction where offers to sell, or solicitations of offers to purchase, the securities offered by this documentation