Company: NDRA
Filing Date: 2025-10-30
Form Type: 424B5
Source: 0001213900-25-103705
Chunk: 45

Company: ENDRA Life Sciences Inc.
Filing Date: 2025-10-30
Form: 424B5
Chunk 45
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 the safe diagnosis and treatment of a number of significant medical conditions in circumstances
where expensive X-ray computed tomography (“CT”), magnetic resonance imaging (“MRI”) technology, or other diagnostic
technologies such as surgical biopsy, are unavailable or impractical.

Our TAEUS technology uses radio frequency (“RF”)
pulses to stimulate tissues, using a small fraction (less than 1%) of the amount of energy that would be transmitted into the body during
an MRI scan. The use of RF energy allows our TAEUS technology to penetrate deep into tissue, enabling the imaging of human anatomy at
depths equivalent to those of conventional ultrasound. The RF pulses are absorbed by tissue and converted into ultrasound signals, which
are detected by an external ultrasound receiver and a digital acquisition system that is part of the TAEUS system. The detected ultrasound
is processed into images and other forms of data using our proprietary software and algorithms and then displayed to complement conventional
gray-scale ultrasound images. The TAEUS imaging concept is illustrated below:

We believe that our TAEUS technology has the potential
to add a number of new capabilities to conventional ultrasound, and other types of capital medical equipment such as interventional thermo-ablation
systems, and thereby enhance the utility of those systems. Additionally, we believe that our technology can extend the use of ultrasound
technology to indications and clinical situations that currently require the use of expensive CT or MRI imaging systems, where imaging
is not practical using existing technology, or where other assessment tools such as surgical biopsy are required.

Our TAEUS platform is not intended to replace
CT or MRI systems, both of which are versatile imaging technologies with capabilities and uses beyond the focus of our business. These
systems, while versatile, are relatively expensive—a CT system can cost approximately $1 million and an MRI system can cost up to
approximately $3 million. In addition, and in contrast to ultrasound systems, due to their limited number and the fact that they are usually
fixed-in-place at major medical facilities, CT or MRI systems are frequently inaccessible to many patients. For example, CT or MRI systems
are generally less accessible to primary care practices, rural clinics, economically developing markets, and patient bedsides.

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Ultrasound systems are more broadly available
to patients than either CT or MRI systems. There are an estimated 1.6 million diagnostic ultrasound systems globally in use today. The
global diagnostic ultrasound device market is anticipated to expand at a CAGR of 4.