Company: PRME
Filing Date: 2025-07-14
Form Type: DEF 14A
Source: 0001193125-25-158716
Chunk: 1

Company: Prime Medicine, Inc.
Filing Date: 2025-07-14
Form: DEF 14A
Chunk 1
---
 the “2022 Plan”) (the “Option Repricing Proposal” or “Proposal 1”);                                                                                 |

| 2. | To approve a proposal to adjourn the Special Meeting to a later date, if necessary or appropriate, to permit                                                                                                                                
 further solicitation and vote of additional proxies in the event that there are insufficient votes for, or otherwise in connection with, the approval of the Option Repricing Proposal at the time of the Special Meeting (the “Adjournment 
 Proposal” or “Proposal 2”); and                                                                                                                                                                                                             |

| 3. | To transact such other business as may properly come before the Special Meeting or any continuations, 
 adjournments, and postponements thereof.                                                              |

The foregoing items of business are more fully described in the proxy statement (the “Proxy Statement”) accompanying this Notice of Special Meeting. Our Board of Directors has established the close of business on July 9, 2025 as the “record date” for the Special Meeting. This means that you are entitled to notice of, and to vote at, the Special Meeting or any continuations, adjournments, and postponements thereof if our stock records show that you owned our common stock at that time. A list of stockholders entitled to vote at the Special Meeting will be available for inspection at our principal executive offices, during normal business hours, by any stockholder for any purpose germane to the Special Meeting, for a period of ten (10) days prior to the Special Meeting. In accordance with the rules of the Securities and Exchange Commission (the “SEC”), we have elected to provide our proxy materials to our stockholders using the “full set delivery option” in connection with the Special Meeting, pursuant to Rule 14a-16(n)under the Securities Exchange Act of 1934, as amended (the “Exchange Act”). As a result, we are delivering to our stockholders paper copies of the accompanying Proxy Statement and form of proxy card (collectively, the “Proxy Materials”) by mail. In addition to delivery of the Proxy Materials to our stockholders, we will post the Proxy Materials on a publicly accessible website and provide information to our stockholders about how to access the website. The Proxy Statement is dated July 14, 2025 and is first being mailed to stockholders on or about July 14, 2025.

Please see the “Information About the Special Meeting and Voting” section of the Proxy Statement that accompanies this notice for more details regarding the logistics of the virtual Special Meeting