Company: LENZ
Filing Date: 2025-04-04
Form Type: S-3
Source: 0001628280-25-016822
Chunk: 3

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-04
Form: S-3
Chunk 3
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 you invest. The aggregate offering price of the securities we sell pursuant to this prospectus will not exceed $500,000,000.

The securities may be sold directly to you, through agents or through underwriters and dealers. If agents, underwriters or dealers are used to sell the securities, we will name them and describe their compensation in a prospectus supplement. The price to the public of those securities and the net proceeds we expect to receive from that sale will also be set forth in a prospectus supplement.

Our Common Stock is listed on the Nasdaq Global Select Market under the symbol “LENZ.” Each prospectus supplement will indicate whether the securities offered thereby will be listed on any securities exchange.

We are an “emerging growth company” and a “smaller reporting company” as defined under the federal securities laws, and, as such, may elect to comply with certain reduced public company reporting requirements for this and future filings. We will provide information in any applicable prospectus supplement regarding any listing of securities other than shares of our common stock on any securities exchange.

Investing in our securities involves risks. Please carefully read the information under the headings “

#### Risk Factors

#### ” beginning on page

#### 4
of this prospectus and “Item 1A – Risk Factors” of our most recent report on Form 10-K or 10-Q that is incorporated by reference in this prospectus before you invest in our securities.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is , 2025.</div>

### TABLE OF CONTENTS
|                                     |     | Page |
| About this Prospectus               |     |   ii |
| Prospectus Summary                  |     |    1 |
| Risk Factors                        |     |    4 |
| Forward‑Looking Statements          |     |    5 |
| Use of Proceeds                     |     |    6 |
| Description of Capital Stock        |     |    7 |
| Description of Debt Securities      |     |    8 |
| Description of Depositary Shares    |     |   16 |
| Description of Warrants             |     |   19 |
| Description of Subscription Rights  |     |   20 |
| Description of Purchase Contracts   |     |   21 |
| Description of Units                |