Company: PFSA
Filing Date: 2025-10-29
Form Type: 424B3
Source: 0001213900-25-103174
Chunk: 46

Company: Profusa, Inc.
Filing Date: 2025-10-29
Form: 424B3
Chunk 46
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, insurance, health and safety protocols, and off-site storage of data. However,
a natural or man-made disaster, such as fire, flood, earthquake, act of terrorism, cyber-attack or other disruptive event, such as the
COVID-19 pandemic or another public health emergency, could cause substantial delays in our operations, damage, destroy or limit our manufacturing
equipment, inventory, or records and cause us to incur additional expenses. Earthquakes and fires are of particular significance since
our manufacturing facilities in California are located in an earthquake-prone area. In the event our existing manufacturing facilities
or equipment are affected by man-made or natural disasters, we may be unable to manufacture products for sale or meet customer demands
or sales projections. If our manufacturing operations were curtailed or ceased, it would seriously harm our business. The insurance we
maintain against fires, floods, earthquakes and other natural disasters and similar events may not be adequate to cover our losses in
any particular case. Further, insurance coverage may not be available or successfully secured for loss profits or business interruption
relating to the COVID-19 pandemic and its impacts.

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Customer or third-party complaints or negative reviews or publicity about our company or our products could harm our reputation and brand.

We expect to rely on customers
who use our products to provide good reviews and word-of-mouth recommendations to contribute to our future growth. Customers who are dissatisfied
with their experiences with our products or services may post negative reviews. We may also be the subject of blog, forum or other media
postings that include inaccurate statements and create negative publicity. Any negative reviews or publicity, whether real or perceived,
disseminated by word-of-mouth, by the general media, by electronic or social networking means or by other methods, could harm our reputation
and brand and could severely diminish consumer confidence in our products.

The size and expected growth of our addressable market has not been established with precision, and may be smaller than we estimate.

Our estimates of the addressable
market for our current products and future products are based on a number of internal and third-party estimates and assumptions, including
the prevalence of diabetes across income levels and demographic profiles. While we believe our assumptions and the data underlying our
estimates are reasonable, these assumptions and estimates may not be correct. In addition, the statements in this prospectus relating
to, among other things, the expected growth in the market for our products, are based on a number of internal