Company: IPSC
Filing Date: 2025-03-20
Form Type: S-8
Source: 0001104659-25-025838
Chunk: 1

Company: Century Therapeutics, Inc.
Filing Date: 2025-03-20
Form: S-8
Chunk 1
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 the Securities Act. ¨                  |             |                 |                      |                  |

<div align='center'>EXPLANATORY NOTE</div>

This Registration Statement is being filed for
the purpose of (i) registering an additional 4,291,821 shares of common stock, $0.0001 par value per share (the “”), of Century Therapeutics, Inc. (the “”) that were added to the shares authorized for
issuance under the Century Therapeutics, Inc. 2021 Equity Incentive Plan (the “”) for which a Registration
Statement on Form S-8 relating to the same employee benefit plan is effective.

The Registrant previously filed Registration Statements on Form S-8 (File Nos. 333-257644, 333-263666, 333-270649 and 333-277930) with
the Securities and Exchange Commission (the “Commission”) to register 14,370,995 shares of Common Stock that were authorized
for issuance under the 2021 Plan. Upon the effectiveness of this Registration Statement, an aggregate of 18,662,816 shares of Common Stock
will be registered for issuance from time to time under the 2021 Plan. Pursuant to General Instruction E to Form S-8, the contents of
the Registration Statement on Form S-8 (File Nos. 333-257644, 333-263666 and 333-270649 and 333-277930) filed with the Commission on July 2, 2021, March 17, 2022, March 17, 2023 and March 14, 2024, respectively, are incorporated herein by reference except to the extent supplemented,
amended or superseded by the information set forth herein. Only those items of Form S-8 containing new information not contained in the
earlier registration statement are presented herein.

<div align='center'>PART I
INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>

| Item 1. | Plan Information. |

The information specified in Part I of Form S-8
is omitted from this filing in accordance with the provisions of Rule 428 under the Securities Act and the introductory note to Part I
of the Form S-8 instructions. The documents containing the information specified in Part I will be delivered to the participants
in the 2021 Plan as required by Rule 428(b)(1) under the Securities Act.

<div align='center'>PART II