Company: XXII
Filing Date: 2025-08-15
Form Type: S-8
Source: 0001641172-25-024491
Chunk: 0

Company: 22nd Century Group, Inc.
Filing Date: 2025-08-15
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on August 15, 2025.</div>

File No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

22nd CENTURY GROUP, INC.

(Exact Name of Registrant as Specified in Its Charter)</div>

| Nevada                            |     | 98-0468420         |
| (State or Other Jurisdiction      
 of Incorporation or Organization) |     | -I.R.S. Employer   
 Identification No. |

<div align='center'>321 Farmington Road, Mocksville North Carolina 27028 (Address of Principal Executive Office)( Zip Code)

AMENDED AND RESTATED 22nd CENTURY GROUP, INC. 2021 OMNIBUS INCENTIVE PLAN

(Full title of the plan)

Jonathan Staffeldt

General Counsel

22nd Century Group, Inc.

321 Farmington Road, Mocksville

North Carolina 27028

(Name and address of agent for service)

(336) 940-3769

(Telephone Number, including area code, for agent for service)

Copy to:

John J. Wolfel, Esq.

Foley & Lardner LLP

One Independent Drive, Suite 1300

Jacksonville, Florida 32202

(904) 359-2000</div>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large               
 accelerated filer ☐ | Accelerated         
 filer ☐             |
| Non-accelerated     
 filer ☒             | Smaller             
 reporting company ☒ |
|                     | Emerging            
 growth company ☐    |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided under Section 7(a)(2)(B) of the Securities Act. ☐

<div align='center'>REGISTRATION OF ADDITIONAL SECURITIES

PURSUANT TO