Company: HURA
Filing Date: 2025-12-10
Form Type: 424B5
Source: 0001193125-25-313799
Chunk: 38

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-12-10
Form: 424B5
Chunk 38
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 change the time for payment of principal or interest on any debt security; |

| • |     | reduce the principal of, or any installment of principal of, or interest on, any debt security; |

| • |     | reduce the amount of premium, if any, payable upon the redemption of any debt security; |

| • |     | reduce the amount of principal payable upon acceleration of the maturity of an original issue discount debt 
 security;                                                                                                   |

| • |     | impair the right to institute suit for the enforcement of any payment on or for any debt security; |

| • |     | reduce the percentage in principal amount of the outstanding debt securities of any series the consent of whose                                                            
 holders is required for modification or amendment of the indenture or for waiver of compliance with certain provisions of the indenture or for waiver of certain defaults; |

| • |     | modify the provisions relating to waiver of some defaults or any of the foregoing provisions; |

| • |     | change the currency of payment; |

| • |     | adversely affect the right to repayment of debt securities of any series at the option of the holders of those 
 debt securities; or                                                                                            |

| • |     | change the place of payment. |

Any supplemental indenture will be filed with the SEC as an exhibit to:

| • |     | a post-effective amendment to the registration statement of which this prospectus is a part; |

| • |     | an annual report on Form 10-K; |

| • |     | a quarterly report on Form 10-Q; or |

| • |     | a current report on Form 8-K. |

Defeasance and Covenant Defeasance When we use the term defeasance, we mean discharge from some or all of our obligations under an indenture. If we deposit with the trustee sufficient cash or government obligations to pay the principal, interest, any premium and any mandatory sinking fund or analogous payments due to the stated maturity or a redemption date of the debt securities of a particular series, then at our option:

| • |     | we will be discharged from our obligations for the debt securities of that series, the holders of the debt 
 securities of the affected series will no longer be entitled to the benefits of the indenture, except for  |

10

| registration of transfer and exchange of debt securities and replacement of lost, stolen or mutilated debt securities, and those holders may look only to the deposited funds or obligations for 
 payment, which is referred to