Company: TAK
Filing Date: 2025-10-30
Form Type: 6-K
Source: 0001395064-25-000154
Chunk: 15

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-10-30
Form: 6-K
Chunk 15
---
 decrease was mainly due to

cost reductions from the termination of certain development programs, the appreciation of the Japanese yen, and cost savings under the enterprise-wide efficiency program. This decrease was partially offset by incremental investments in late-stage pipelines.

<div align='center'>- 9 -</div>

Translation for reference purpose only

#### Core Net Profit for the Period
Core Net Profit for the Period was JPY 438.7 billion ( JPY -50.5 billion and -10.3% AER, -11.1% CER) and Core Net Profit attributable to owners of the Company was JPY 438.6 billion (JPY -50.5 billion and -10.3% AER, -11.1% CER) and are calculated from Core Operating Profit as below:

|                                                                                  |     |           |     |            |        |     |           |     |          |        |     |     |     |          |       |     |       |   |     |     |       | Billion JPY or percentage |
|                                                                                  |     | FY2024 H1 |     |            |        |     | FY2025 H1 |     |          |        |     | AER |     |          |       |     |       |   | CER |     |       |                           |
|                                                                                  |     |           |     | JPY Change |        |     |           |     | % Change |        |     |     |     | % Change |       |     |       |   |     |     |       |                           |
| Core operating profit                                                            |     |           |     |            |  719.9 |     |           |     |          |  639.2 |     |     |     |          | -80.7 |     | -11.2 | % |     |     |  -8.8 | %                         |
| Core finance income and (expenses), net                                          |     |           |     |            |  -73.3 |     |           |     |          |  -67.1 |     |     |     |          |   6.2 |     |  -8.4 | % |     |     |  -7.1 | %                         |
| Core share of profit (loss) of investments accounted for using the equity method |     |           |     |            |    1.6 |     |           |     |          |   -0.6