Company: PTHS
Filing Date: 2025-09-19
Form Type: S-3/A
Source: 0001753926-25-001541
Chunk: 0

Company: Pelthos Therapeutics Inc.
Filing Date: 2025-09-19
Form: S-3/A
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on September 19, 2025</div>

Registration No. 333-289916

<div align='center'>UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM S-3/A

(Amendment No. 1)

REGISTRATION STATEMENT UNDER THE
SECURITIES ACT OF 1933

PELTHOS THERAPEUTICS INC.

(Exact name of registrant as specified in its charter)</div>

| Nevada                         |     | 86-3335449         |
| (State                         
 or other jurisdiction of       
 incorporation or organization) |     | -I.R.S.            
 Employer           
 Identification No. |

<div align='center'>Pelthos Therapeutics Inc.
4020 Stirrup Creek Drive, Suite 110

Durham, NC 27703
(919) 908-2400
(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

Nevada Agency and Transfer Company
50 West Liberty Street, Suite 880

Reno, NV 89501
(775) 322-0626
(Name, address including zip code, and telephone number, including area code, of agent for service)

With copies to:

David E. Danovitch, Esq.
Charles E. Chambers Jr., Esq.
Sullivan & Worcester LLP
1251 Avenue of the Americas, 19 thFloor
New York, NY 10020
(212) 660-3060</div>

Approximate date of commencement of proposed sale to the public: From time to time after the effective date of this registration statement.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box. ☒

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a post-effective amendment filed pursuant to Rule 462(c) under