Company: APM
Filing Date: 2025-12-05
Form Type: 424B5
Source: 0001213900-25-118752
Chunk: 145

Company: Aptorum Group Ltd
Filing Date: 2025-12-05
Form: 424B5
Chunk 145
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:

| ● | Regulatory Changes and Governmental Control: The PRC government                                                                       
 has significant authority to intervene in the operations of businesses, and any changes in laws, regulations, or enforcement policies 
 could adversely impact our operations in Hong Kong and any future opportunities in the region.                                        |

| ● | Geopolitical and Economic Instability: Ongoing tensions between                                                                            
 the PRC and other countries, particularly the U.S., may affect trade policies, tariffs, and overall market conditions, which could disrupt 
 our supply chain or future business in Hong Kong.                                                                                          |

| ● | Currency and Capital Flow Restrictions: The PRC government imposes                                                                      
 controls on the movement of funds into and out of the country, which could limit our ability to repatriate funds or invest in remaining 
 operations.                                                                                                                             |

| ● | Hong Kong’s Evolving Legal Environment: The integration                                                                   
 of certain aspects of Hong Kong’s governance with the PRC’s legal framework has created uncertainties regarding autonomy, 
 regulatory consistency, and legal protections.                                                                            |

Any adverse developments related
to our operations in Hong Kong could have a material adverse effect on our business, financial condition, and results of operations.

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Uncertainties with respect to the legal system of the People’s Republic of China (the “PRC”) and tax regime, including uncertainties regarding the enforcement of laws, and sudden or unexpected changes in policies, laws, and regulations in the PRC could adversely affect us.

We are subject to certain legal
and operational risks associated with having operations in Hong Kong. The PRC legal system is based in part on government policies
and internal rules, some of which are not published on a timely basis, or at all, and may have retroactive effect. As a result, we may
not be aware of our violation of any of these policies and rules until sometime after the violation. Such unpredictability towards our
contractual, property and procedural rights and any failure to quickly respond to changes in the regulatory environment in the PRC could
adversely affect our business, financial condition, and results of operations, and impede our ability to continue our operations in Hong Kong.

The PRC government may intervene
or influence our operations at any time as the PRC government deems appropriate to further regulatory, political and societal goals, which
may potentially result in a material adverse effect on our operations. We cannot rule out the possibility that it will in the future release
regulations or policies regarding our industry