Company: HURA
Filing Date: 2025-12-10
Form Type: 424B5
Source: 0001193125-25-313799
Chunk: 24

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-12-10
Form: 424B5
Chunk 24
---
. The SEC maintains a web site, www.sec.gov, that contains reports, proxy and information statements and other information regarding issuers that file electronically with the SEC. You may review the registration statement and any other document we file on the SEC’s web site. Our SEC filings are also available to the public on our website, www.tuhurabio.com. The information on our website, however, is not, and should not be deemed to be, a part of this prospectus supplement. We are “incorporating by reference” specified documents that we file with the SEC, which means:

| • |     | incorporated documents are considered part of this prospectus supplement; |

| • |     | we are disclosing important information to you by referring you to those documents; and |

| • |     | information that we file with the SEC will automatically update and supersede information contained in this 
 prospectus supplement.                                                                                      |

We incorporate by reference into this prospectus supplement the documents listed below and any future filings we make with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (i) after the date of filing of the registration statement of which this prospectus supplement is a part and prior to the effectiveness of such registration statement and (ii) on or after the date of this prospectus supplement until the earlier of the date S-19

on which all of the securities registered hereunder have been sold or the registration statement of which this prospectus supplement is a part has been withdrawn:

Notwithstanding the foregoing, information furnished under Items 2.02 and 7.01 of any Current Report on Form 8-K,including the related exhibits under Item 9.01, is not incorporated by reference in this prospectus supplement. You may request a copy of any of these filings, at no cost, by request directed to us at the following address or telephone number: TuHURA Biosciences, Inc. 10500 University Center Drive, Suite 110 Tampa, Florida 33612 (813) 875-6600 Attention: Chief Financial Officer You should not assume that the information in this prospectus supplement, as well as the information we file or previously filed with the SEC that we incorporate by reference in this prospectus supplement, is accurate as of any date other than the respective date of such documents. Our business, financial condition, results of operations and prospects may have changed since that date. S-20

PROSPECTUS

$250