Company: AZN
Filing Date: 2025-09-29
Form Type: 6-K
Source: 0001104659-25-094039
Chunk: 17

Company: ASTRAZENECA PLC
Filing Date: 2025-09-29
Form: 6-K
Chunk 17
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 information regarding certain UK, US and Swedish taxation consequences of the Harmonised Listing Structure, including the termination of the existing ADR Programme and the Settlement System Migration. Shareholders who are in any doubt about their tax position are strongly recommended to consult an appropriately qualified independent professional adviser immediately.

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TABLE OF CONTENTS

### PART IIISETTLEMENT AND DEALINGS IN ASTRAZENECA SHARESFOLLOWING THE SETTLEMENT SYSTEM MIGRATION

#### Shareholders are advised to read this Part III (
**Settlement and Dealings in AstraZeneca Shares following the Settlement System Migration ) carefully to ensure that they understand the arrangements that will apply to them following the implementation of the Harmonised Listing Structure (including the Settlement System Migration).**

#### 1.
**Overview of existing arrangements in respect of AstraZeneca’s listed securities**

As at the date of this document, holders of AstraZeneca Shares traded on the London Stock Exchange (the

#### “London Listed Shares”
) have the option to hold interests in AstraZeneca Shares either directly in certificated form with the holder named on the Register of Members or in uncertificated form through CREST with trades settled through the CREST settlement system.

The Swedish Listed Shares are all currently held in uncertificated form within CREST by Euroclear Sweden as custodian on behalf of the relevant Shareholders, with trades settled through by way of local book entries within the Euroclear Sweden system.

American depositary shares representing uncertificated AstraZeneca Shares (the

#### “AstraZeneca ADSs”
) are currently traded on Nasdaq on a two for one basis pursuant to the ADR Programme. The AstraZeneca ADSs are evidenced by American depositary receipts (

#### “AstraZeneca ADRs”
). The AstraZeneca Shares underlying the AstraZeneca ADSs are currently held within CREST by Guaranty Nominees Limited, as nominee for the ADR Depositary.

The AstraZeneca US Bonds are currently traded on Nasdaq and settled through DTC.

#### 2.
**Changes to Settlement and Dealings in AstraZeneca Shares at the Effective Time

(a)**

#### DTC Eligible London Listed Shares

#### Issuance of AstraZeneca DIs
Following the Settlement System Migration, AstraZeneca Shares will no longer be capable of transfer or settlement directly through the CREST settlement system. For this reason, from the Effective Time