Company: PSTV
Filing Date: 2025-04-23
Form Type: S-3/A
Source: 0001193125-25-091456
Chunk: 7

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-23
Form: S-3/A
Chunk 7
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 the sources of such revenue; |

| • |     | our ability to effectively manage our gross profit margins; |

| • |     | our potential need for additional financing and the availability thereof; |

| • |     | our ability to continue as a going concern; |

| • |     | our ability to remain listed on Nasdaq; |

| • |     | our estimates regarding expenses, capital requirements, and needs for additional financing and our ability to 
 obtain additional capital;                                                                                    |

| • |     | our ability to repay or refinance some or all of our outstanding indebtedness and our ability to raise capital in 
 the future;                                                                                                       |

| • |     | our ability to integrate into our business and operations, develop, fully utilize and monetize acquired assets; |

| • |     | our ability to transfer the drug product manufacturing to a contract drug manufacturing organization; |

| • |     | the potential enhancement of our cash position through development, marketing, and licensing arrangements; |

| • |     | the implementation of our business model, strategic plans for our business, and product candidates; |

| • |     | our ability to contract with third-party suppliers and manufacturers and their ability to perform adequately; |

| • |     | our ability to prevent or timely detect a material security breach or cyber security attack affecting our 
 operations and property;                                                                                  |

| • |     | our use of the proceeds from any exercise of the Warrants; and |

| • |     | other factors detailed under the section entitled “Risk Factors” in this prospectus. |

We have based these forward-looking statements largely on our current expectations and projections about future events and financial trends that we believe may affect our business, financial condition and results of operations. Forward-looking statements are not guarantees of future performance, conditions or results, and are subject to risks, uncertainties and assumptions that are difficult to predict. Therefore, actual results may differ materially and adversely from those anticipated in any forward-looking statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this prospectus. While we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete, and our statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all potentially available relevant information. We undertake no obligation to update or revise any forward-looking statements contained in this prospectus, whether as a result of new information, future events or otherwise. iv

PROSPECT