Company: SCLXW
Filing Date: 2025-05-15
Form Type: 424B3
Source: 0000950170-25-071904
Chunk: 3

Company: Scilex Holding Co
Filing Date: 2025-05-15
Form: 424B3
Chunk 3
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4.    | Controls and Procedures                                                               |   53 |
| PART II.   | OTHER INFORMATION                                                                     |   54 |
| Item 1.    | Legal Proceedings                                                                     |   54 |
| Item 1A.   | Risk Factors                                                                          |   55 |
| Item 2.    | Unregistered Sales of Equity Securities and Use of Proceeds                           |   68 |
| Item 3.    | Defaults Upon Senior Securities                                                       |   68 |
| Item 4.    | Mine Safety Disclosures                                                               |   68 |
| Item 5.    | Other Information                                                                     |   68 |
| Item 6.    | Exhibits                                                                              |   69 |
| Signatures |                                                                                       |   73 |

<div align='center'>i

SCILEX HOLDING COMPANY</div>

In this Quarterly Report on Form 10-Q, unless the context requires otherwise, references to the “Company”, “Scilex”, “we”, “us”, “our”, and similar terms refer to Scilex Holding Company, a Delaware corporation formerly known as Vickers Vantage Corp. I (“Vickers”), and its consolidated subsidiaries. References to “Legacy Scilex” refer to the private Delaware corporation that is now our wholly owned subsidiary and named Scilex, Inc. (formerly known as “Scilex Holding Company”).

On November 10, 2022, we consummated a business combination pursuant to the Agreement and Plan of Merger, dated as of March 17, 2022 (as amended, the “Merger Agreement”), by and among Vickers, Vantage Merger Sub Inc. (“Merger Sub”), a wholly owned subsidiary of Vickers, and Legacy Scilex. Pursuant to the terms of the Merger Agreement, the business combination (herein referred to as the “Business Combination” or “reverse recapitalization” for accounting purposes) between Vickers and Legacy Scilex was effected through the merger of Merger Sub with and into Legacy Scilex with Legacy Scilex surviving as Vickers’s wholly owned subsidiary. In connection with the Business Combination, Vickers changed its name from Vickers Vantage Corp. I to Scilex Holding Company.

Unless otherwise noted or the context requires otherwise, references to our “Common Stock” refer to our common stock, par value $0.0001 per share.

<div align='center'>CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS</