Company: NDRA
Filing Date: 2025-11-06
Form Type: S-3
Source: 0001213900-25-107232
Chunk: 0

Company: ENDRA Life Sciences Inc.
Filing Date: 2025-11-06
Form: S-3
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on November 6, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-3

REGISTRATION STATEMENT UNDER THE SECURITIES
ACT OF 1933

ENDRA Life Sciences Inc.

(Exact name of registrant as specified in its
charter)</div>

| Delaware               |     | 26-0579295         |
| (State or jurisdiction 
 of incorporation or    
 organization)          |     | -I.R.S. Employer   
 Identification No. |

<div align='center'>3600 Green Court, Suite 350

Ann Arbor, MI 48105-1570

(734) 335-0468

(Address, including zip code, and telephone number,
including area code, of registrant’s principal executive offices)</div>

| Alexander Tokman                             
 Chief Executive Officer                      
 ENDRA Life Sciences Inc.                     
 3600 Green Court, Suite 350                  
 Ann Arbor, MI 48105-1570                     
 (734) 335-0468                               
 (Name, address and telephone number of agent 
 for service)                                 |     | Copy to:                        
 Mark R. Busch, Esq.             
 Coleman Wombwell, Esq.          
 K&L Gates LLP                   
 300 South Tryon St., Suite 1000 
 Charlotte, NC 28202             
 (704) 331-7400                  |

Approximate date of commencement of proposed
sale to the public: From time to time on or after the effectiveness of this Registration Statement, as determined by market conditions
and other factors.

If the only securities being registered on this
Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐

If any of the securities being registered on
this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities
offered only in connection with dividend or interest reinvestment plans, check the following box: ☒

If this Form is filed to register additional
securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act
registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a post-effective amendment filed