Company: SHPH
Filing Date: 2025-11-18
Form Type: S-1
Source: 0001493152-25-024089
Chunk: 2

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-11-18
Form: S-1
Chunk 2
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 issued to the selling stockholder in connection with a private placement we completed on November 4, 2025. We will not receive any of the proceeds from the sale by the selling stockholder of the shares.

The selling stockholder may sell or otherwise dispose of the shares covered by this prospectus in a number of different ways and at varying prices. We provide more information about how the selling stockholder may sell or otherwise dispose of the shares covered by this prospectus in the section entitled “ Plan of Distribution” on page 8. Discounts, concessions, commissions and similar selling expenses attributable to the sale of shares covered by this prospectus will be borne by the selling stockholder. We will pay all expenses (other than discounts, concessions, commissions and similar selling expenses) relating to the registration of the shares with the Securities and Exchange Commission, or the SEC.

You should carefully read this prospectus, together with the documents we incorporate by reference, before you invest in our common stock.

Our common stock is listed on The Nasdaq Capital Market under the symbol “SHPH.” On November 17, 2025, the last reported sale price for our common stock was $1.92 per share.

Investing in our common stock involves substantial risk. Please read “ Risk Factors” beginning on page 6 of this prospectus and in the documents we incorporate by reference.

Neither the SEC nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is ____, 2025</div>

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<div align='center'>TABLE OF CONTENTS</div>

| ABOUT THIS PROSPECTUS                                |  4 |
| SUMMARY                                              |  4 |
| RISK FACTORS                                         |  6 |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS |  6 |
| USE OF PROCEEDS                                      |  6 |
| SELLING STOCKHOLDER                                  |  7 |
| PLAN OF DISTRIBUTION                                 |  8 |
| LEGAL MATTERS                                        |  9 |
| EXPERTS                                              |  9 |
| INFORMATION INCORPORATED BY REFERENCE                | 10 |
| WHERE YOU CAN FIND MORE INFORMATION                  | 10 |

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<div align='center'>ABOUT THIS PROSPECTUS</div>

This prospectus is part of a registration statement that