Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 161

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 161
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 aggregate of up to 34,286 shares of Common Stock, the exercise price of
which is $43.75 per share.

On October 8, 2024, we issued the October 2024 Noteholder Warrants (as defined below) to purchase an
aggregate of 214,284 shares of Common Stock. On the same date, we also issued the October 2024 Placement Agent Warrants (as defined below) to purchase an aggregate of 104,848 shares of Common Stock, which became exercisable 180 days following the
date of issuance. The current exercise price of both the October 2024 Noteholder Warrants and the October 2024 Placement Agent Warrants is $36.40 per share. As described elsewhere in this prospectus, on July 22, 2025, we entered into the
Warrant Exchange Agreements with the Tranche B Investors, pursuant to which October 2024 Noteholder Warrants to purchase up to 107,142 shares of Common Stock were surrendered in exchange for the Exchange Warrants. Oramed waived its right to
participate in the exchange.

On December 13, 2024, we issued the December 2024 RDO
Pre-Funded Warrants (as defined below) to purchase an aggregate of 68,604 shares of Common Stock, which have been fully exercised as of the date of this prospectus. On the same date, we also issued the
December 2024 RDO Common Warrants (as defined below) to purchase an aggregate of 1,642,871 shares of Common Stock and the StockBlock Warrants (as defined below) to purchase an aggregate of 131,472 shares of Common Stock, which will become
exercisable 180 days following the date of issuance. The exercise price of both the December 2024 RDO Common Warrants and the StockBlock Warrants is $22.72 per share and $25.81 per share, respectively.

On September 30, 2025, we issued the September 2025 Warrants to purchase an aggregate of 275,000 shares of Common Stock, which are
currently exercisable for an aggregate of 275,000 shares of Common Stock, the exercise price of which is $20.00 per share.

On
November 25, 2025, we issued the November 2025 Investor Warrant to purchase an aggregate of 1,356,594 shares of Common Stock, which are currently exercisable