Company: SPRB
Filing Date: 2025-10-29
Form Type: S-3
Source: 0001193125-25-256662
Chunk: 3

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-10-29
Form: S-3
Chunk 3
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 comply with reduced public company reporting requirements in future filings.

Investing in our securities involves a high degree of risk. Before making an investment decision, you should review carefully the risks and uncertainties described under the heading “Risk Factors” on page5of this prospectus as well as those contained in the applicable prospectus supplement and in any free writing prospectuses we may authorize for use in connection with a specific offering, and under similar headings in the other documents that are incorporated by reference into this prospectus.

NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

The date of this prospectus is , 2025.

TABLE OF CONTENTS

|                                                        | Page |
| ABOUT THIS PROSPECTUS                                  |    i |
| PROSPECTUS SUMMARY                                     |    1 |
| RISK FACTORS                                           |    5 |
| SELECTED FINANCIAL DATA REFLECTING REVERSE STOCK SPLIT |    6 |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS      |    8 |
| USE OF PROCEEDS                                        |    9 |
| DESCRIPTION OF CAPITAL STOCK                           |   10 |
| DESCRIPTION OF DEBT SECURITIES                         |   14 |
| DESCRIPTION OF WARRANTS                                |   21 |
| LEGAL OWNERSHIP OF SECURITIES                          |   24 |
| PLAN OF DISTRIBUTION                                   |   28 |
| LEGAL MATTERS                                          |   31 |
| EXPERTS                                                |   31 |
| WHERE YOU CAN FIND MORE INFORMATION                    |   31 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE      |   31 |

This prospectus is a part of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission, or the SEC, utilizing a “shelf” registration process. Under this shelf registration process, we may offer and sell any combination of the securities described in this prospectus in one or more offerings up to a total aggregate offering price of $300,000,000. This prospectus provides you with a general description of the securities we may offer.

Each time we sell securities under this prospectus, we will provide a prospectus supplement that will contain specific information about the terms of that offering. We may also