Company: SCLXW
Filing Date: 2025-05-07
Form Type: POS AM
Source: 0001193125-25-115088
Chunk: 35

Company: Scilex Holding Co
Filing Date: 2025-05-07
Form: POS AM
Chunk 35
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, refinancing, redemption or repurchase of indebtedness or capital stock. See “Use of Proceeds” elsewhere in this prospectus. |

| Market for our Common Stock | Our Common Stock is listed on the Nasdaq Capital Market under the symbol “SCLX”. |

| Risk factors | See “Risk Factors” beginning on page 23 and other information included in this prospectus for a discussion of factors you should carefully consider before deciding to invest in the securities being offered by this prospectus. |

| (1) | The number of shares of Common Stock outstanding assumes that an aggregate of 6,951,671 shares are outstanding immediately prior to the completion of this offering, which number is based on an aggregate of 6,951,671 shares outstanding as of December 31, 2024, taking into account the Reverse Stock Split, with |

21

| • |     | 18,665 shares of Common Stock issuable upon the exercise of stock options outstanding under the 2017 Scilex Pharmaceuticals Inc. Equity Incentive Plan (the “Scilex Pharma 2017 Plan”) with a weighted average exercise price of $26.95 per share; |

| • |     | 432,087 shares of Common Stock issuable upon the exercise of stock options outstanding under the 2019 Stock Option Plan of Scilex, Inc. (the “2019 Stock Option Plan”) with a weighted average exercise price of $60.55 per share; |

| • |     | 571,738 shares of Common Stock issuable upon the exercise of stock options outstanding under the Scilex Holding Company 2022 Equity Incentive Plan (the “Equity Incentive Plan”), with a weighted average exercise price of $200.55 per share; |

| • |     | up to 494,662 shares of Common Stock available for future issuance under the Equity Incentive Plan; |

| • |     | up to 118,350 shares of Common Stock available for future issuance under the Scilex Holding Company 2022 Employee Stock Purchase Plan (the “ESPP”); |

| • |     | up to 40,000 shares of Common Stock available for future issuance under the Scilex Holding Company 2023 Inducement Plan (the “Inducement Plan”); |

| • |     | up to 6,958,309 SPAC Warrants (as defined below on a pre-Reverse Stock Split basis), which are currently exercisable for