Company: CERO
Filing Date: 2025-01-07
Form Type: 424B3
Source: 0001213900-25-001661
Chunk: 3

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-01-07
Form: 424B3
Chunk 3
---
 Events.

On December 6, 2024, the Company
issued a press release announcing Mr. Ehrlich’s appointment as the Chief Executive Officer. The full text of
the press release is attached as Exhibit 99.1 to this Current Report on Form 8-K and incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

The following exhibits are furnished herewith:

| Exhibit No. 
 99.1        |     | Description                                                                  
 Press release, dated December 6, 2024.                                       |
|:------------|:----|:-----------------------------------------------------------------------------|
| 104         |     | Cover Page Interactive Data File (embedded within the Inline XBRL document). |

<div align='center'>1

SIGNATURES</div>

Pursuant to the requirements
of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto
duly authorized.

| Date: December 6, 2024 | CERO THERAPEUTICS HOLDINGS, INC. |                         |
|:-----------------------|:---------------------------------|:------------------------|
|                        | By:                              | /s/ Chris Ehrlich       |
|                        | Name:                            | Chris Ehrlich           |
|                        | Title:                           | Chief Executive Officer |

<div align='center'>2

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or Section 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): January 6, 2025

CERO THERAPEUTICS HOLDINGS, INC.

(Exact name of registrant as specified in its charter)</div>

| Delaware                        |     | 001-40877               |     | 87-1088814            |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -Commission File Number |     | -I.R.S. Employer      
 Identification Number |

| 201 Haskins Way, Suite 230, South San Francisco, CA |     |     94080 |
| (Address of principal executive offices)            |     | -Zip Code |

<div align='center'>(650) 407-2376

Registrant’s telephone number, including area code

Not Applicable