Company: CSTL
Filing Date: 2025-02-27
Form Type: S-8
Source: 0001447362-25-000032
Chunk: 2

Company: CASTLE BIOSCIENCES INC
Filing Date: 2025-02-27
Form: S-8
Chunk 2
---
2019 Plan, incorporated by reference to Exhibit 10.7 to the Registrant’s Registration Statement on Form S-1 (File No. 333-232369), originally filed with the SEC on June 26, 2019, as amended.                                        |
| 99.3           |     | Forms of Restricted Stock Unit Grant Notice and Restricted Stock Unit Award Agreement under the 2019 Equity Incentive Plan, incorporated by reference to Exhibit 10.1 to the Registrant's Quarterly Report on Form 10-Q, filed with SEC on November 9, 2020.                                                                |
| 99.4           |     | Castle Biosciences, Inc. 2019 Employee Stock Purchase Plan, incorporated by reference to Exhibit 10.8 to the Registrant’s Registration Statement on Form S-1 (File No. 333-232369), originally filed with the SEC on June 26, 2019, as amended.                                                                             |
| 107*           |     | Filing Fee Table                                                                                                                                                                                                                                                                                                            |

__________________________________

* Filed herewith.

### SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Friendswood, State of Texas, on February 27, 2025.

| CASTLE BIOSCIENCES, INC. |     |                                       |
| By:                      |     | /s/ Derek J. Maetzold                 |
|                          |     | Derek J. Maetzold                     |
|                          |     | President and Chief Executive Officer |

### POWER OF ATTORNEY
KNOW ALL BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Derek J. Maetzold and Frank Stokes, and each of them, as his or her true and lawful attorneys-in-fact and agents, each with the full power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and