Company: HURA
Filing Date: 2025-12-10
Form Type: 424B5
Source: 0001193125-25-313799
Chunk: 0

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-12-10
Form: 424B5
Chunk 0
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Filed pursuant to Rule 424(b)(5)
Registration No. 333-291239

PROSPECTUS SUPPLEMENT

(To Prospectus Dated November 22, 2025)

9,462,423 Shares of Common Stock

9,462,423 Series A Warrants to Purchase Shares of Common Stock

9,462,423 Series B Warrants to Purchase Shares of Common Stock

283,873 Placement Agent Warrants to Purchase Shares of Common Stock

19,208,719 Shares of Common Stock Issuable Upon the Exercise of Such Series A Warrants, Series B Warrants and Placement Agent Warrants

This is an offering of 9,462,423 shares of our Common Stock, par value $0.001 per share (the “Common Stock”) together with Series
A warrants (the “Series A Warrants”) to purchase up to 9,462,423 shares of Common Stock and Series B warrants (the “Series B Warrants”) to purchase up to 9,462,423 shares of Common Stock, with the Series A Warrants and the
Series B Warrants referred to herein collectively as the “Warrants.” The offering price for one share of Common Stock and accompanying Series A Warrant and Series B Warrant is $1.65. The shares of Common Stock and the Warrants will be
issued separately and will be immediately separable upon issuance but will be purchased together in this offering. The Warrants will have an exercise price of $1.95 per share and will not be exercisable until six months after the date of issuance.
The Series A Warrants will expire five and a half years after the first closing and the Series B Warrants will expire two years after the first closing of this offering. This prospectus supplement and the accompanying prospectus also registers the
shares of Common Stock issuable upon the exercise of the Warrants sold in this offering. This offering also relates to the shares of Common Stock issuable upon exercise of the Warrants and the Placement Agent Warrants (as defined below).

We and K&V Investment One LLC (“K&V”) entered into a side letter to the securities purchase agreement for the offering
whereby K&V has agreed to purchase $7 million shares of our Common Stock and accompanying Warrants in this offering at the offering price set forth below, but at two separate, delayed closings with K&V purchasing $5 million of our
securities at the second closing and $2 million of our securities at the third closing