Company: JPC
Filing Date: 2025-03-04
Form Type: DEF 14A
Source: 0001193125-25-045738
Chunk: 4

Company: Nuveen Preferred & Income Opportunities Fund
Filing Date: 2025-03-04
Form: DEF 14A
Chunk 4
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 United States. To vote by telephone, please call the toll-free number located on your proxy card and follow the recorded instructions, using your proxy card as a guide. To vote over the Internet, go to the Internet address provided on your proxy card and follow the instructions, using your proxy card as a guide.

Mark L. Winget

Vice President and Secretary

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| Joint Proxy Statement |     | 333 West Wacker Drive   
 Chicago, Illinois 60606 
 (800) 257-8787          |

March 4, 2025

This Joint
Proxy Statement is first being mailed to shareholders on or about March 7, 2025.

Nuveen Core Equity Alpha Fund (JCE)

Nuveen Core Plus Impact Fund (NPCT)

Nuveen Credit Strategies Income Fund (JQC)

Nuveen Dow 30 SMDynamic Overwrite Fund (DIAX)

Nuveen Floating Rate Income Fund (JFR)

Nuveen Global High Income Fund (JGH)

Nuveen Minnesota Quality Municipal Income Fund (NMS)

Nuveen Missouri Quality Municipal Income Fund (NOM)

Nuveen Mortgage and Income Fund (JLS)

Nuveen Multi-Asset Income Fund (NMAI)

Nuveen Multi-Market Income Fund (JMM)

Nuveen Municipal Credit Opportunities Fund (NMCO)

Nuveen NASDAQ 100 Dynamic Overwrite Fund (QQQX)

Nuveen Preferred & Income Opportunities Fund (JPC)

Nuveen Real Asset Income and Growth Fund (JRI)

Nuveen Real Estate Income Fund (JRS)

Nuveen S&P 500 Buy-WriteIncome Fund (BXMX)

Nuveen S&P 500 Dynamic Overwrite Fund (SPXX)

Nuveen Variable Rate Preferred & Income Fund (NPFD)

Nuveen Virginia Quality Municipal Income Fund (NPV)

1

General Information

This Joint Proxy Statement is furnished in connection with the solicitation by the Board of Trustees (each a “Board” and collectively, the “Boards,”
and each Trustee, a “Board Member” and collectively, the “Board Members”) of each of Nuveen Core Equity Alpha Fund (“Core Equity Alpha”), Nuveen Core Plus Impact Fund (“Core Plus Impact”), Nuveen Credit
Strategies Income Fund (“Credit Strategies”), Nuveen Dow 30 Dynamic Overwrite Fund (“Dow Dynamic Overwrite”), Nuveen Floating Rate Income Fund (“Floating Rate
Income”),