Company: SMNR
Filing Date: 2025-12-03
Form Type: S-8
Source: 0001193125-25-306969
Chunk: 1

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-12-03
Form: S-8
Chunk 1
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Item 1. Plan Information.

The
document(s) containing the information specified in Part I will be sent or given to participants as specified by Rule 428(b)(1) of the Securities Act. Such documents are not being filed with the Securities and Exchange Commission (the
“Commission”) either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424 of the Securities Act. Such documents and the documents incorporated by reference in this Registration
Statement pursuant to Item 3 of Part II hereof, taken together, constitute a prospectus that meets the requirements of Section 10(a) of the Securities Act.

PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE. The following documents filed by the Registrant with the Commission are hereby incorporated by reference into this Registration Statement:

| 1. | The Registrant’s prospectus filed with the Commission under Rule 424(b)(3) of the Securities Act on August 13, 2025; |

| 4. | The description of the Registrant’s Common Stock contained in Exhibit 4.1 to the Registrant’s                                                                                    
 Current Report on Form 8-K filed with the Commission on December                                                                                                                 
 3, 2025, which updates the description of the Registrant’s Common Stock contained in the Registration Statement on Form 8-A                                                      
 (File No. 001-41351) filed with the Commission on April 6, 2022, pursuant to Section 12(b) of the Exchange Act, and any amendments or reports filed for the purpose of updating, 
 amending, or otherwise modifying such description.                                                                                                                               |

All other reports and other documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities then remaining unsold, shall be deemed to be incorporated by reference into this Registration Statement and to be a part of this Registration Statement from the date of the filing of such reports and documents, except as to any portion of any future annual or quarterly report to stockholders or document or current report furnished under Items 2.02 or 7.01 of Form 8-Kthat is not deemed filed under such provisions. For the purposes of this Registration Statement, any statement contained in a document incorporated or deemed to be incorporated by