Company: OSRH
Filing Date: 2025-01-24
Form Type: S-4/A
Source: 0001213900-25-006139
Chunk: 283

Company: OSR Holdings, Inc.
Filing Date: 2025-01-24
Form: S-4/A
Chunk 283
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0. 2The forecasted market size and growth are limited due to a dearth of treatment options available. Hepatocellular Cancer (HCC) Market Hepatocellular carcinoma (HCC) is the most common form of liver cancer and accounts for ~90% of all primary liver cancers, making it the third leading cause of cancer mortality worldwide. 3OSR Holdings’ research indicates that the prevalence of hepatocellular carcinoma was highest in China, followed by the US and Japan in 2023. The increasing prevalence of HCC is driving hepatocellular carcinoma treatment market growth. According to estimates, more than 1 million people will be affected with hepatocellular carcinoma annually by 2025. 4 Nexavar, approved in 2007, is the only available targeted treatment option for patients with advanced HCC, and, since its launch, has dominated the HCC market in the seven major markets (7MM: US, France, Germany, Italy, Spain, UK, and Japan). Nexavar’s patent protection in the 7MM market expired in December 2022, and generic sorafenib has entered the market. ____________ 1Stupp, R., et al. (2005). “Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma.” New England Journal of Medicine, 352(10), 987 -996 2 https://www.biospace.com/article/glioblastoma -multiforme-treatment-market-size-to-hit-10-2-bn-by-2030 3Villanueva, A. (2019). “Hepatocellular Carcinoma.” New England Journal of Medicine, 380(15), 1450 -1462 4 https://www.arizton.com/market -reports /hepatocellular -carcinoma-treatment-market 168 The global HCC treatment market is projected to be valued at $14.18 billion by 2031, from $3.87 billion in 2023 at a CAGR of 17.61%. 5 Metastatic Colorectal Cancer (mCRC) Market The market for global metastatic colorectal cancer is projected to grow at a CAGR of 3.58% for the period 2024 -2031, growing from USD 3.91 billion in 2023 to USD 5.18 billion in 2031. 6The increasing prevalence of colore