Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 83

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 83
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 exceed one vote per share, or without voting powers, and with such designations, preferences and relative, participating, optional or other special rights, and qualifications, limitations or
restrictions thereof, as the Board of Directors may determine.

Prior to the issuance of any series of preferred stock, the board of directors of Comerica
will adopt resolutions creating and designating the series as a series of preferred stock, and the resolutions will be filed in a certificate of designations as an amendment to the Certificate of Incorporation. The term “board of directors of
Comerica” includes any duly authorized committee.

4

The rights of holders of the preferred stock offered may be adversely affected by the rights of holders of any shares of preferred stock that may be issued in the future. The board of directors may cause shares of preferred stock to be issued in public or private transactions for any proper corporate purpose. Examples of proper corporate purposes include issuances to obtain additional financing in connection with acquisitions or otherwise and issuances to officers, directors and employees of Comerica and its subsidiaries pursuant to benefit plans or otherwise. Shares of preferred stock issued by Comerica may have the effect of rendering more difficult or discouraging an acquisition of Comerica deemed undesirable by the board of directors of Comerica. Under regulations adopted by the Federal Reserve, if the holders of any series of preferred stock are or become entitled to vote for the election of directors, such series will be deemed a “class of voting securities” and a company holding 25% or more of the series, or 5% or more if it otherwise has the ability to exercise a “controlling influence” over us, may then be subject to regulation as a bank holding company in accordance with the Bank Holding Company Act of 1956, as amended. In addition, at the time the series is deemed a class of voting securities,

| • |     | any other bank holding company may be required to obtain the approval of the Federal Reserve (or any successor                         
 bank regulatory authority that may become our applicable federal banking agency) to acquire or retain more than 5% of that series; and |

| • |     | any other persons other than a bank holding company may be required to obtain the                                                                                                        
 non-objection of the Federal Reserve (or any successor bank regulatory authority that may become our applicable federal banking agency) to acquire or retain 10% or more of that series. |

Before exercising its option to redeem any shares of preferred stock, Comerica will obtain the approval