Company: NOTV
Filing Date: 2025-08-29
Form Type: S-3
Source: 0001628280-25-041413
Chunk: 58

Company: Inotiv, Inc.
Filing Date: 2025-08-29
Form: S-3
Chunk 58
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                     |     | $ |   3.44 |     |   |       |
| As-adjusted net tangible book value (deficit) per share after giving effect to the offering(1) |     |   |        |     | $ | -2.37 |
| Dilution in net tangible book value (deficit) per share to new investors                       |     |   |        |     | $ | -4.11 |

__________________

(1) Assuming a purchase price of $1.74, which was the closing price of our common shares on Nasdaq on August 26, 2025.

The foregoing table excludes the following:

• 1,409,268 common shares issuable upon the exercise of stock options outstanding as of June 30, 2025 at a weighted-average exercise price of $2.47 per common share;

• 914,941 common shares reserved for future issuance under our 2024 Equity Incentive Plan as of June 30, 2025;

• 1,700,940 common shares reserved for issuance upon the vesting of restricted stock units outstanding as of June 30, 2025;

• 2,859,306 common shares reserved for issuance as of June 30, 2025 upon the conversion of our outstanding 3.25% Convertible Senior Notes due 2027; and

• 3,034,124 common shares reserved for issuance upon the exercise of warrants outstanding as of June 30, 2025.

<div align='center'>S-9</div>

### PLAN OF DISTRIBUTION
We have entered into a sales agreement with Jefferies, under which we may offer and sell up to $50.0 million of our common shares from time to time through Jefferies acting as agent. Sales of our common shares, if any, under this prospectus supplement and the accompanying prospectus will be made by any method that is deemed to be an “at the market offering” as defined in Rule 415(a)(4) under the Securities Act or in privately negotiated transactions.

Each time we wish to issue and sell our common shares under the sales agreement, we will notify Jefferies of the number of shares to be issued, the dates on which such sales are anticipated to be made, any limitation on the number of shares to be sold in any one day and any minimum price below which sales may not be made. Once we have so instructed Jefferies, unless Jefferies declines to accept the terms