Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 78

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 78
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“Where You Can Find More Information.”

Statements in this prospectus about the terms or contents of any agreement or other document included as
an exhibit to the registration statement of which this prospectus is a part are not necessarily complete. Refer to such agreement or document itself for a complete description of these matters.

You should rely only on the information contained or incorporated by reference in this prospectus or any supplement. Comerica has not authorized anyone else
to provide you with different information. Comerica is offering these securities only in states where the offer is permitted. You should not assume that the information in this prospectus or any supplement is accurate as of any date other than the
date on the front of such a document. Comerica’s business, financial condition, results of operations and prospects may have changed since that date.

In the prospectus, unless the context requires otherwise, references to Comerica, we, us or our are to Comerica Incorporated and its consolidated
subsidiaries.

FORWARD-LOOKING STATEMENTS

This prospectus and the documents incorporated by reference in this prospectus include forward-looking statements as defined in the Private Securities
Litigation Reform Act of 1995. All statements regarding Comerica’s future financial position, strategies and growth prospects, as well as competitive, economic or market conditions are forward-looking statements. Words such as anticipates,
believes, contemplates, feels, expects, estimates, seeks, strives, plans, intends, outlook, forecast, position, target, mission, assume, achievable, potential, strategy, goal, aspiration, opportunity, initiative, outcome, continue, remain, maintain,
on track, trend, objective, looks forward, projects, models, will, would, should, could,” might, can, may and similar expressions, and variations of such words and similar expressions, identify forward-looking statements. These include,
among other things, descriptions of plans and objectives of Comerica’s management for future or past operations, products or services, and forecasts of Comerica’s revenue, earnings or other measures of economic performance, including
statements of profitability, business segments and subsidiaries, as well as estimates of credit trends and global stability. Comerica makes these forward-looking statements on its management’s beliefs and assumptions as of the date of this
prospectus and do not speak as of any other date. They are also subject to risks and uncertainties, and Comerica’s actual results could materially differ.

Risks that could cause or contribute to such