Company: KROS
Filing Date: 2025-02-26
Form Type: S-8
Source: 0001664710-25-000020
Chunk: 0

Company: Keros Therapeutics, Inc.
Filing Date: 2025-02-26
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on February 26, 2025</div>

#### Registration No. 333
#### -

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

#### FORM S-8

### REGISTRATION STATEMENT

#### UNDER

#### THE SECURITIES ACT OF 1933

#### Keros Therapeutics, Inc.
<div align='center'>(Exact name of Registrant as specified in its charter)</div>

| Delaware                                 |     |         81-1173868 |
| (State or other jurisdiction of          
 Incorporation or organization)           |     |   -I.R.S. Employer 
 Identification No. |
| 1050 Waltham Street, Suite 302           
 Lexington, Massachusetts                 |     |              02421 |
| (Address of principal executive offices) |     |          -Zip code |

#### 2020 Equity Incentive Plan

#### 2020 Employee Stock Purchase Plan
<div align='center'>(Full title of the plan)</div>

#### Jasbir Seehra

#### Chief Executive Officer

#### Keros Therapeutics, Inc.

#### 1050 Waltham Street, Suite 302

#### Lexington, Massachusetts 02421

#### Tel: (617) 314-6297
<div align='center'>(Name and address of agent for service) (Telephone number, including area code, of agent for service)</div>

<div align='center'>Copies to:</div>

| Marc A. Recht               
 Ryan S. Sansom              
 Brandon Fenn                
 Cooley LLP                  
 500 Boylston Street         
 Boston, Massachusetts 02116 
 (617) 937-2300              |     | Esther Cho                     
 General Counsel                
 Keros Therapeutics, Inc.       
 1050 Waltham Street, Suite 302 
 Lexington, Massachusetts 02421 
 (617) 314-6297                 |

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer |     | xo |     | Accelerated filer         |