Company: MDCXW
Filing Date: 2025-05-30
Form Type: 424B3
Source: 0001062993-25-010580
Chunk: 100

Company: Medicus Pharma Ltd.
Filing Date: 2025-05-30
Form: 424B3
Chunk 100
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Protocol P171016-1 R3 governs this process. |
| Fabrication of each fixture necessary for array production |     | Protocol P171016-1 R3 provides these parameters                                                                                                                                                                                                                                                     |

| In-Process Controls (Formulation)               |     | Limit                                                                                                                                                                         |
| Dissolution of all materials in gel formulation |     | Visual inspection                                                                                                                                                             |
| Viscosity of the gel                            |     | Verified by cone plate viscometer torque reading; Brookefield Viscometer DVII+ calibrated at every run                                                                        |
| pH of the gel                                   |     | A pH of between 4.5 and 5.1 is sufficiently acidic. Follow procedure for dilution of gel, use of pH probe, and calculation (Determination of the pH of SkinJect Formulations) |

| In-Process Controls (Array Fabrication) |     | Limit                                                                                                             |
| Deposition and centrifugation.          |     | Deposit approximately 0.5 ml per 2 x 5 production mold. The centrifuge is run for 30 minutes at 5,500 rpm at 15C. |
| Doxorubicin stability                   |     | Temperature maintained within centrifuge at 15C that impacts drying.                                              
 Refrigeration of arrays once fabricated at 2-8°C                                                                  |

The flow chart, below, describes in more detail the critical steps and manufacturing parameters. A summary narrative of the process is provided on subsequent pages.

<div align='center'>- 62 -

Figure 2. Manufacturing flow chart</div>

Manufacturing Process Equipment

The equipment used to fabricate the arrays is listed in the table below:

Equipment Used to Fabricate Arrays

| Description            |     | Supplier     |     | Model/Part Number/Print                           |
| Centrifuge             |     | Thermofisher |     | Sorvall Lynx 4000                                 |
| Rotor                  |     | Thermofisher |     | BioFlex HC (PN 75003000Q502807)                   |
| Rotor Bucket           |     | Thermofisher |     | BioFlex HC (PN 75003000Q502807)                   |
| Bucket Lid with Gasket |     | Thermofisher |     | BioFlex HC Lid (PN 75007309Q502807)               |
| Bucket Insert          |     | GFE LLC      |     | GFE Print "Lynx Square Tool Holder Rev R1"        |
| Casting Mask           |