Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 95

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 95
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 |     | Total |
|:---------------------------------|:----|:-------------|:----|:-------------|:----|:------|
| Public Offering Price            |     | $            |     | $            |     | $     |
| Placement Agent Fees             |     | $            |     | $            |     | $     |
| Proceeds to Us (before expenses) |     | $            |     | $            |     | $     |

We have also agreed to reimburse the Placement Agent for (i) certain of its offering-related expenses, including for its legal fees and expenses and other out-of-pocketexpenses in an amount up to $120,000, and (ii) certain non-accountableexpenses in an amount up to $10,000. 66

Confidential Treatment Requested by Nucana plc

Pursuant to 17 C.F.R. Section 200.83

We estimate the total expenses of this offering payable by us, excluding the Placement
Agent’s fees, will be approximately $ .

Lock-upAgreements

We and each of our officers and directors have agreed with the Placement Agent to be subject to a
lock-up period of ninety (90) days following the date of closing of the offering pursuant to this prospectus. This means that, during the applicable lock-up period,
we may not issue, enter into any agreement to issue or announce the issuance or proposed issuance of any ADSs, ordinary shares or ordinary share equivalents, file any registration statement or amendment or supplement, or effect or enter into an
agreement to effect any issuance by us of ADSs, ordinary shares or ordinary share equivalents (as defined in the securities purchase agreement) (or a combination of units thereof) involving a variable rate transaction (as defined in the securities
purchase agreement), subject to customary exceptions. The Placement Agent and purchaser may waive the terms of this lock-up period in their discretion.

Additionally, our officers and directors may not offer, pledge, announce the intention to sell, sell, contract to sell, sell any option or
contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, make any short sale or otherwise transfer or dispose of, directly or indirectly, enter any swap or other arrangement that transfers, and
make any demand for or exercise any right with respect to the registration of any of our ordinary shares, ADSs or any securities convertible into, or exercisable or exchangeable for, our ordinary shares or ADSs, subject to