Company: NCNA
Filing Date: 2025-06-27
Form Type: 424B5
Source: 0001193125-25-151464
Chunk: 75

Company: NuCana plc
Filing Date: 2025-06-27
Form: 424B5
Chunk 75
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 the holder’s ADSs as follows:

| • |     | In the event of voting by show of hands, the depositary will vote (or cause the custodian to vote) all ordinary                                                    
 shares held on deposit at that time in accordance with the voting instructions received from a majority of holders of ADSs who provide timely voting instructions. |

| • |     | In the event of voting by poll, the depositary will vote (or cause the custodian to vote) the ordinary shares 
 held on deposit in accordance with the voting instructions received from the holders of ADSs.                 |

The depositary will not join in demanding a vote by poll. Securities for which no voting instructions have been received will not be voted (except as otherwise contemplated herein). If voting is by poll and the depositary does not receive timely voting instructions from a holder of ADSs, such holder shall be deemed to have instructed the depositary to give a discretionary proxy to a person designated by us to vote the deposited securities represented by such ADSs in any manner such person wishes, which may not be in your best interests; provided, however, that no such discretionary proxy shall be given with respect to any matter to be voted upon as to which we inform the depositary that (a) we do not wish such proxy to be given, (b) substantial opposition exists, or (c) the rights of holders of deposited securities may be adversely affected. Please note that the ability of the depositary to carry out voting instructions may be limited by practical and legal limitations and the terms of the securities on deposit. We cannot assure you that you will receive voting materials in time to enable you to return voting instructions to the depositary in a timely manner. Fees and Charges As an ADS holder, you will be required to pay the following fees under the terms of the deposit agreement:

| Service                                                                                                       |     | Fee                                                                                     |
| Issuance of ADSs (e.g., an issuance of ADS upon a deposit of ordinary shares or upon a change in              
 the ADS(s)-to-ordinary shares ratio), excluding ADS issuances as a result of distributions of ordinary shares |     | Up to $0.05 per ADS issued                                                              |
| Cancellation of ADSs (e.g., a cancellation of ADSs for delivery of deposited property or upon a               
 change in the ADS(s)-to-ordinary shares ratio)                                                                |     | Up to $0.05 per ADS cancelled                                                           |
| Distribution of cash dividends or other cash distributions (e.g., upon