Company: ARWR
Filing Date: 2025-03-07
Form Type: 424B7
Source: 0001193125-25-049889
Chunk: 6

Company: ARROWHEAD PHARMACEUTICALS, INC.
Filing Date: 2025-03-07
Form: 424B7
Chunk 6
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. is a wholly-owned subsidiary of Sarepta Therapeutics, Inc. The address of each of Sarepta Therapeutics Investments, Inc. and Sarepta Therapeutics, Inc. is 215 First Street, Cambridge, MA 02142. |

S-7

PLAN OF DISTRIBUTION We are registering the Shares issued to the Selling Stockholder to permit the resale of these Shares by the holder of the Shares from time to time after the date of this prospectus supplement. We will not receive any of the proceeds from the sale by the Selling Stockholder of the Shares. We will, or will procure to, bear all fees and expenses incident to our obligation to register the Shares. The Selling Stockholder may sell all or a portion of the Shares beneficially owned by them and offered hereby from time to time directly or through one or more underwriters, broker-dealers or agents. As used in this prospectus supplement, “Selling Stockholder” includes donees, pledgees, transferees or other successors in interest selling securities received from the Selling Stockholder as a gift, pledge, partnership distribution or other transfer. If the Shares are sold through underwriters or broker-dealers, the Selling Stockholder will be responsible for underwriting discounts or commissions or agent’s commissions. The Shares may be sold on any national securities exchange or quotation service on which the securities may be listed or quoted at the time of sale, in the over-the-counter marketor in transactions otherwise than on these exchanges or systems or in the over-the-counter marketand in one or more transactions at fixed prices, at prevailing market prices at the time of the sale, at varying prices determined at the time of sale, or at negotiated prices. These sales may be effected in transactions, which may involve crosses or block transactions or distributions in kind for no consideration. The Selling Stockholder may use any one or more of the following methods when selling Shares:

| • |     | distributions to members, partners, stockholders or other equityholders of the Selling Stockholder; |

| • |     | ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers; |

| • |     | block trades in which the broker-dealer will attempt to sell the shares as agent but may position and resell a 
 portion of the block as principal to facilitate the transaction;                                               |

| • |     | purchases by a broker-dealer as principal and resale by the broker-dealer for its account; |

| • |     | an exchange distribution in accordance with the rules