Company: MIRM
Filing Date: 2025-08-12
Form Type: S-3ASR
Source: 0001193125-25-178937
Chunk: 59

Company: Mirum Pharmaceuticals, Inc.
Filing Date: 2025-08-12
Form: S-3ASR
Chunk 59
---
 City, California 94404, or by telephoning us at (650) 667-4085. Any statement contained herein or in a document incorporated or deemed to be incorporated by reference into this document will be deemed to be modified or superseded for purposes of the document to the extent that a statement contained in this document or any other subsequently filed document that is deemed to be incorporated by reference into this document modifies or supersedes the statement. S-16

Up to $200,000,000 Common Stock PROSPECTUS SUPPLEMENT

| Leerink Partners |     | Cantor |

August 12, 2025

PART II INFORMATION NOT REQUIRED IN PROSPECTUS Item 14. Other Expenses of Issuance and Distribution The following table sets forth the estimated costs and expenses, other than underwriting discounts and commissions, payable by us in connection with the offering of the securities being registered. All the amounts shown are estimates, except for the SEC registration fee.

| SEC registration fee                |     | $ |     | *  |
| FINRA filing fee                    |     |   |     | ** |
| Accounting fees and expenses        |     |   |     | ** |
| Legal fees and expenses             |     |   |     | ** |
| Transfer agent fees and expenses    |     |   |     | ** |
| Trustee fees and expenses           |     |   |     | ** |
| Printing and miscellaneous expenses |     |   |     | ** |
| Total                               |     | $ |     | ** |

| * | Pursuant to Rules 456(b) and 457(r), we are deferring payment of all applicable registration fees. |

| ** | These fees are calculated based on the securities offered and the number of issuances and accordingly cannot be 
 estimated at this time.                                                                                         |

Item 15. Indemnification of Directors and Officers We are incorporated under the laws of the State of Delaware. Section 145 of the General Corporation Law of the State of Delaware, or the DGCL, empowers a Delaware corporation to indemnify any persons who are, or are threatened to be made, parties to any threatened, pending, or completed legal action, suit, or proceeding, whether civil, criminal, administrative, or investigative (other than an action by or in the right of such corporation), by reason of the fact that such person was an officer or director of such corporation, or is or was serving at the request of such corporation as a director, officer