Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 8

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 8
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 systems or infrastructure, or those of third parties, could fail or be                                                                                
 breached, which could disrupt Comerica’s business and adversely impact the Company’s results of operations, liquidity and financial condition, as well as cause legal or reputational harm; |

S-iv

| • |     | the Company relies on other companies to provide certain key components of its delivery systems, and certain 
 failures could materially adversely affect operations;                                                       |

| • |     | legal and regulatory proceedings and related financial services industry matters, including those directly                    
 involving the Company and its subsidiaries, could adversely affect the Company or the financial services industry in general; |

| • |     | the Company may incur losses due to fraud; |

| • |     | controls and procedures may fail to prevent or detect all errors or acts of fraud; |

| • |     | changes in regulation or oversight, or changes in the Company’s status with respect to existing regulations 
 or oversight, may have a material adverse impact on the Company’s operations;                               |

| • |     | compliance with more stringent capital requirements may adversely affect the Company; |

| • |     | changes to tax law or regulations, or changes to administrative or judicial interpretations of tax law or 
 regulations, could adversely affect the Company;                                                          |

| • |     | damage to the Company’s reputation could damage its businesses; |

| • |     | the Company may not be able to utilize technology to develop, market and deliver new products and services to its 
 customers;                                                                                                        |

| • |     | competitive product and pricing pressures within the Company’s markets may change; |

| • |     | the introduction, implementation, withdrawal, success and timing of business initiatives and strategies may be 
 less successful or may be different than anticipated, which could adversely affect the Company’s business;     |

| • |     | management’s ability to maintain and expand customer relationships may differ from expectations; |

| • |     | management’s ability to retain key officers and employees may change; |

| • |     | any future strategic acquisitions or divestitures may present certain risks to the Company’s business and 
 operations;                                                                                               |

| • |     | general political, economic or industry conditions, either domestically or internationally, may be less favorable 
 than expected;                                                                                                    |

| • |     | inflation has impacted, and could continue to negatively impact, the Company’s business, profitability and 
 stock price;                                                                                               |

| • |     | methods of reducing risk exposures might not be effective;