Company: TEM
Filing Date: 2025-08-08
Form Type: S-3ASR
Source: 0001193125-25-175993
Chunk: 3

Company: Tempus AI, Inc.
Filing Date: 2025-08-08
Form: S-3ASR
Chunk 3
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 securities with respect to which this prospectus is being delivered, the names of such agents, underwriters or dealers and any applicable
fees, commissions, discounts and over-allotment options will be set forth in a prospectus supplement. The price to the public of such securities and the net proceeds we expect to receive from such sale will also be set forth in a prospectus
supplement.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is August 8, 2025.

TABLE OF CONTENTS

|                                                   |     | Page |     |
| ABOUT THIS PROSPECTUS                             |     |      |   i |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |      | iii |
| PROSPECTUS SUMMARY                                |     |      |   1 |
| RISK FACTORS                                      |     |      |   6 |
| USE OF PROCEEDS                                   |     |      |   7 |
| DESCRIPTION OF CAPITAL STOCK                      |     |      |   8 |
| DESCRIPTION OF DEBT SECURITIES                    |     |      |  14 |
| DESCRIPTION OF WARRANTS                           |     |      |  21 |
| LEGAL OWNERSHIP OF SECURITIES                     |     |      |  23 |
| PLAN OF DISTRIBUTION                              |     |      |  27 |
| LEGAL MATTERS                                     |     |      |  29 |
| EXPERTS                                           |     |      |  29 |
| WHERE YOU CAN FIND MORE INFORMATION               |     |      |  29 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE |     |      |  30 |

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and
Exchange Commission (the “SEC”) utilizing a “shelf” registration process as a “well-known seasoned issuer” as defined in Rule 405 under the Securities Act of 1933, as amended (the “Securities Act”). Under this
shelf registration process, we may offer and sell shares of our common stock and preferred stock, various series of debt securities and/or warrants to purchase any of such securities, either individually or in combination with other securities, in
one or more offerings. There is no limit on