Company: APM
Filing Date: 2025-10-14
Form Type: 424B5
Source: 0001213900-25-098635
Chunk: 50

Company: Aptorum Group Ltd
Filing Date: 2025-10-14
Form: 424B5
Chunk 50
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 such modified or new laws and regulations will have on Aptorum Group’s daily business operations, its ability to accept foreign investments and the listing of Aptorum Class A ordinary shares on a U.S. or other foreign exchange. If there is significant change to current political arrangements between mainland China and Hong Kong, the PRC government intervenes or influences operations of companies operated in Hong Kong like us, or exerts more control through change of laws and regulations over offerings conducted overseas and/or foreign investment in issuers like us, it may result in a material change in our operations and/or the value of the securities we are registering for sale or could significantly limit or completely hinder our ability to offer or continue to offer securities to investors and cause the value of Aptorum Class A ordinary shares to significantly decline or become worthless. (Please see the risk factor section, “Risks Related to our Corporate Structure” and “Risks Related to Doing Business in Hong Kong” for more information). Hong Kong Regulation The operations of laboratory in Hong Kong are subject to certain general laws and regulations. Waste Disposal Ordinance The Waste Disposal Ordinance (Chapter 354 of the Laws of Hong Kong) (“WDO”) and the Waste Disposal (Clinical Waste) (General) Regulation (Chapter 354O of the Laws of Hong Kong) (the “WDR”) provide for, among others, the control and regulation of the production, storage, collection, and disposal of clinical waste. Under the WDO, clinical waste means waste consisting of any substance, matter or thing generated in connection with:

| ● | a dental, medical, nursing or veterinary practice; |

| ● | any other practice, or establishment (howsoever described),                                                   
 that provides medical care and services for the sick, injured, infirm or those who require medical treatment; |

| ● | dental, medical, nursing, veterinary, pathological, or pharmaceutical 
 research; or                                                          |

| ● | a dental, medical, veterinary, or pathological laboratory 
 practice,                                                 |

and which consists wholly or partly of any of the materials specified in one or more of the groups listed below:

| ● | used or contaminated sharps; |

| ● | laboratory waste; |

| ● | human and animal tissues; |

| ● | infectious materials; |

| ● | dressings; and |

| ● | such other wastes as specified by the Director of the Environmental 
 Protection Department (“EPD”) of Hong Kong.                         |

Given the research works in our R&D Center may produce used or contaminated shar