Company: FENC
Filing Date: 2025-11-18
Form Type: S-8
Source: 0001104659-25-113660
Chunk: 0

Company: FENNEC PHARMACEUTICALS INC.
Filing Date: 2025-11-18
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on November 18, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

FENNEC PHARMACEUTICALS INC.

(Exact Name of Registrant as Specified in Its Charter)</div>

| British                        
 Columbia, Canada               |     | 20-0442384         |
| (State                         
 or Other Jurisdiction of       
 Incorporation or Organization) |     | -I.R.S.            
 Employer           
 Identification No. |

<div align='center'>PO Box 13628, 68 TW Alexander Drive

Research Triangle Park, NC 27709

(Address of Principal Executive Offices) (Zip Code)

Fennec Pharmaceuticals Inc. 2020 Equity Incentive Plan

(Full Title of the Plans)

Jeff Hackman

Chief Executive Officer

PO Box 13628, 68 TW Alexander Drive

Research Triangle Park, NC 27709

(Name and Address of Agent for Service)

(919) 636-4530

(Telephone Number, including Area Code, of Agent for Service)

Copies to:</div>

| Garett Sleichter, Esq.         | Randy Taylor, Esq.          |
| Rutan & Tucker, LLP            | LaBarge Weinstein LLP       |
| 18575 Jamboree Road, 9th Floor | 515 Legget Drive, Suite 800 |
| Irvine, CA 92612               | Ottawa, ON K2K 3G4          |
| (714) 641-5100                 | (613) 599-9600              |

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer | ¨ | Accelerated filer         | ¨ |
| Non-accelerated filer   | x | Smaller reporting company | x |
|                         |   | Emerging growth company   | �