Company: CERO
Filing Date: 2025-07-28
Form Type: S-8
Source: 0001213900-25-068283
Chunk: 2

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-07-28
Form: S-8
Chunk 2
---
                                                                     |

| * | Filed herewith. |

<div align='center'>II-1

SIGNATURES</div>

Pursuant to the requirements of the Securities Act of 1933, the Registrant
certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the city of South San Francisco, State
of California, on July 28, 2025.

| CERO THERAPEUTICS HOLDINGS, INC. |                                                |
| By:                              | /s/ Chris Ehrlich                              |
| Name:                            | Chris Ehrlich.                                 |
| Title:                           | Chairman, Chief Executive Officer and Director |

<div align='center'>POWER OF ATTORNEY AND SIGNATURES</div>

KNOW ALL PERSONS BY THESE
PRESENTS, that each person whose signature appears below constitutes and appoints each of Chris Ehrlich and Andrew Kucharchuk as such
person’s true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for such person in such
person’s name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments)
to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto, and other documents in connection therewith,
with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority
to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and
purposes as such person might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any
of them, or any substitutes or substitute, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements
of the Securities Act of 1933, as amended, this registration statement has been signed below by the following person in the capacities
and on the dates indicated.

| Signature             
 /s/ Chris Ehrlich     |     | Title                                             
 Chairman and Chief Executive Officer and Director |     | Date          
 July 28, 2025 |
|:----------------------|:----|:--------------------------------------------------|:----|:--------------|
| Chris E