Company: AEMD
Filing Date: 2025-07-25
Form Type: DRS
Source: 0001683168-25-005397
Chunk: 0

Company: AETHLON MEDICAL INC
Filing Date: 2025-07-25
Form: DRS
Chunk 0
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<div align='center'>Confidential Treatment Requested by Aethlon Medical, Inc..
Pursuant to 17 C.F.R. Section 200.83

As submitted confidentially to the Securities and Exchange Commission on July 25, 2025.

This draft registration statement has not been publicly filed with the Securities and Exchange Commission, and all information herein remains strictly confidential.</div>

Registration Statement No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-1

REGISTRATION STATEMENT

Under

THE SECURITIES ACT OF 1933

AETHLON MEDICAL, INC.

(Exact name of registrant as specified in its charter)</div>

| Nevada                          |     |                         3826 |     | 13-3632859            |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -Primary Standard Industrial 
   Classification Code Number |     | -I.R.S. Employer      
 Identification Number |

<div align='center'>11555 Sorrento Valley Road, Suite 203

San Diego, CA 92121

(619) 941-0360

(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

James B. Frakes

Chief Executive Officer

Aethlon Medical, Inc.

11555 Sorrento Valley Road, Suite 203

San Diego, CA 92121

(619) 941-0360

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copies to:</div>

| Dennis Doucette, Esq.                   
 Procopio Cory Hargreaves & Savitch, LLP 
 12544 High Bluff Drive                  
 Suite 400                               
 San Diego, CA 92130                     
 Tel: (858) 720 6303                     |     | M. Ali Panjwani           
 Pryor Cashman LLP         
 7 Times Square            
 New York, NY 10036-6569   
 Telephone: (212) 326-0846 
 Fax: (212) 326-0806       |

Approximate date of commencement of proposed sale to public: As soon as practicable after this Registration Statement is declared effective.

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of