Company: RVRC
Filing Date: 2025-12-12
Form Type: S-1/A
Source: 0001213900-25-121070
Chunk: 105

Company: Revium Rx.
Filing Date: 2025-12-12
Form: S-1/A
Chunk 105
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 could reach $632 million to 1.26 billion annually. This reflects the premium pricing typical of targeted liposomal oncology
therapeutics, but also accounts for lower payer ability to reimburse outside the U.S. and greater variability in adoption and uptake
across geographies.

Estimated Market Opportunity Summary for Nano-Candesartan (Liposomal ARB) in Pancreatic Cancer

| Geography |     | Estimated               
 Annual Cases            |     | Assumed Pricing (per patient)                     |     | TAM (100%    
 Coverage)    |     | SOM                 
 (Realistic          
 Penetration)        |
| U.S.      |     | ~61,000 new PDAC cases  |     | ~$12,950–$25,900 (3.5 months PPPM: $3,700–$7,400) |     | ~$0.8B–$1.6B |     | ~$390M–$790M        
 at ~50% penetration |
| Global    |     | ~495,000 new PDAC cases |     | ~$12,950–$25,900 (same per-patient assumption)    |     | ~$3.2B–$6.3B |     | ~$0.6B–$1.3B        
 at ~20% penetration |

The assumed pricing profile is based on benchmarks from other liposomal oncology drugs. While its potential use in a high-mortality, high-cost indication supports commercial attractiveness and significant global revenue potential, these estimates reflect our assumptions that are illustrative only. Actual outcomes will depend on future clinical trial results, regulatory approvals, regimen.

This product candidate is still in preclinical
development and has not been approved by any regulatory authority. We do not yet know the final dosage, or number of injections required
per treatment course, and actual pricing will depend on multiple factors including clinical results, regulatory approval, reimbursement,
adoption, and competition.

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References

| 1. | American Cancer Society. Pancreatic Cancer Survival 
 Rates. https://www.cancer.org                       |

| 2. | GoodRx (2024). Gemzar and Abraxane Pricing Estimates. 
 https://www.goodrx.com                                |

| 3. | Drugs.com (2024). Candesartan Cost Data. https://www.drugs.com |

| 4. | SEER Cancer Statistics                                                       
 (2023). Pancreatic