Company: XXII
Filing Date: 2025-01-31
Form Type: S-3
Source: 0001493152-25-004469
Chunk: 2

Company: 22nd Century Group, Inc.
Filing Date: 2025-01-31
Form: S-3
Chunk 2
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 of Common Stock</div>

This prospectus relates to the resale from time to time by the selling stockholders named in this prospectus under the caption “Selling Stockholders,” or the Selling Stockholders, of up to 104,124 shares of our common stock, par value $0.00001 per share, or the shares. We will not receive any proceeds from the sale of shares being sold by the selling stockholders.

We have agreed to bear all of the expenses incurred in connection with the registration of these shares. The selling stockholders will pay or assume brokerage commissions and similar charges, if any, incurred for the sale of the shares. The selling stockholders identified in this prospectus may offer the shares from time to time through public or private transactions at fixed prices, at prevailing market prices, at varying prices determined at the time of sale, or at privately negotiated prices. We provide more information about how the selling stockholders may sell their shares of common stock in the section titled “Plan of Distribution” beginning on page 9 of this prospectus. We will not be paying any underwriting discounts or commissions in connection with any offering of shares under this prospectus.

Our common stock is listed on the Nasdaq Capital market under the symbol “XXII.” On January 30, 2025, the closing price of our common stock was $4.06 per share.

Investment in our common stock involves risks. Please read carefully the section entitled “Risk Factors” on page 1 of this prospectus, our most recent Annual Report on Form 10-K, subsequently filed Quarterly Reports on Form 10-Q and in any applicable prospectus supplement and/or other offering material for a discussion of certain factors which should be considered in an investment of the common stock which may be offered hereby.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is , 2025.</div>

<div align='center'>TABLE OF CONTENTS</div>

| About This Prospectus                           | ii |
| 22nd Century Group, inc.                        |  1 |
| Use of Proceeds                                 |  1 |
| Risk Factors                                    |  1 |
| Description of Capital Stock                    |  2 |
| Selling Stockholders                            |  7 |
| Plan of Distribution                            |  9 |
| Legal Matters