Company: SCLXW
Filing Date: 2025-11-14
Form Type: 424B3
Source: 0001193125-25-283329
Chunk: 5

Company: Scilex Holding Co
Filing Date: 2025-11-14
Form: 424B3
Chunk 5
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 and enhance our corporate reputation and brand;

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anticipated regulatory and legal developments in the United States and foreign countries in which we may seek regulatory
approval for our product candidates in the future;

the impact from future regulatory, judicial and legislative changes in our industry;

our ability to obtain and maintain regulatory approval of any of our product candidates;

our ability to research, discover and develop additional product candidates;

our ability to grow and manage growth profitably;

our ability to obtain and maintain intellectual property protection and not infringe on the rights of others;

our ability to execute our business plans and strategy;

our ability to prevent, respond to, and recover from a cybersecurity incident;

the effect of any geopolitical conflicts or new or increased international tariffs, including mitigation efforts and economic effects, on any of the foregoing or other aspects of our business operations, including but not limited to our clinical studies and clinical trials;

the effect of global economic and political developments, including the conflicts in Ukraine and Israel;

regulatory developments related to crypto assets and crypto asset markets;

a determination that we are an investment company under the Investment Company Act of 1940 (the “1940 Act”);

our ability successfully adopt and execute on our new cryptocurrency treasury strategy;

any changes in the accounting treatment of cryptocurrency holdings;

general volatility in the cryptocurrency market; and

other factors detailed under the section titled “Risk Factors” in the Annual Report on Form 10-K, as updated by the risk factors described in the section of this Quarterly Report on Form 10-Q titled “ Risk Factors. ”

Should one or more of these risks or uncertainties materialize or should any of the assumptions made by our management prove incorrect, actual results may vary in material respects from those projected in these forward-looking statements. There may be additional risks that we consider immaterial or which are unknown. It is not possible to predict or identify all such risks. We do not undertake any obligation to update, add or to otherwise correct any forward-looking statements contained herein to reflect events or circumstances after the date they were made, whether as a result of new information, future events, inaccuracies that become apparent after the date hereof or otherwise, except as may be required under applicable securities laws.

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PART I—FIN ANCIAL INFORMATION Item 1. Fin ancial Statements SCILEX HOLDING COMPANY CONDENSED CONSOLIDATED BALANCE SHEETS (In thousands, except for par value and share amounts) (Unaudited)

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