Company: SPRB
Filing Date: 2025-03-31
Form Type: NT 10-K
Source: 0000950170-25-047912
Chunk: 0

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-03-31
Form: NT 10-K
Chunk 0
---
<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 12b-25</div>

### NOTIFICATION OF LATE FILING
| (Check one): |     | ☒  Form 10-K  ☐  Form 20-F    ☐  Form 11-K  ☐  Form 10-Q☐  Form 10-D  ☐  Form N-CEN  ☐  Form N-CSR 
 For Period Ended: December 31, 2024                                                                |
|:-------------|:----|:---------------------------------------------------------------------------------------------------|
|              |     | ☐  Transition Report on Form 10-K                                                                  |
|              |     | ☐  Transition Report on Form 20-F                                                                  |
|              |     | ☐  Transition Report on Form 11-K                                                                  |
|              |     | ☐  Transition Report on Form 10-Q                                                                  |
|              |     | For the Transition Period Ended:                                                                   |

| Read Instruction (on back page) Before Preparing Form. Please Print or Type. Nothing in this Form shall be construed to imply that the Commission has verified any information contained herein. |

If the notification relates to a portion of the filing checked above, identify the Item(s) to which the notification relates:

# PART I — REGISTRANT INFORMATION
<div align='center'>Spruce Biosciences, Inc.

Full Name of Registrant

N/A

Former Name if Applicable

611 Gateway Boulevard, Suite 740

Address of Principal Executive Office (Street and Number)

South San Francisco, CA 94080

City, State and Zip Code

PART II — RULES 12b-25(b) AND (c)</div>

If the subject report could not be filed without unreasonable effort or expense and the registrant seeks relief pursuant to Rule 12b-25(b), the following should be completed. (Check box if appropriate)

| ☒ |    | -a |                                                                                                                                                                                                                                                                                                                                                                                                                                                                         | The reason described in reasonable detail in Part III of this form could not be eliminated without unreasonable effort or expense; |
|   | -b |    | The subject annual report, semi-annual report, transition report on Form 10-K, Form 20-F, Form 11-K, Form N-CEN or Form N-CSR, or portion thereof,