Company: TEM
Filing Date: 2025-08-08
Form Type: S-3ASR
Source: 0001193125-25-175993
Chunk: 62

Company: Tempus AI, Inc.
Filing Date: 2025-08-08
Form: S-3ASR
Chunk 62
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 use commercially reasonable efforts consistent with normal trading and sales practices, on mutually agreed terms between the sales agents and us. There is no arrangement for funds to be received in any escrow, trust or similar arrangement. The sales agents may also purchase shares of our Class A common stock as principal. The sales agents will be entitled to compensation at a commission rate of up to 3.0% of the gross sales price per share sold by the sales agents under the sales agreement. In connection with the sale of Class A common stock on our behalf, the sales agents may be deemed to be “underwriters” within the meaning of the Securities Act and the compensation of the sales agents will be deemed to be underwriting commissions or discounts. See “Plan of Distribution” beginning on page 8 for additional information regarding underwriting compensation. We have also agreed to provide indemnification and contributions to the sales agents against certain civil liabilities, including liabilities under the Securities Act. Investing in our Class A common stock involves a high degree of risk. You should review carefully the risks and uncertainties described in the section titled “ Risk Factors” on page 5 of this prospectus and under similar headings in the documents that are incorporated by reference into this prospectus. Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

| Morgan Stanley |     | Cantor |     | TD Securities |     | Allen & Company LLC |

The date of this prospectus is August 8, 2025.

TABLE OF CONTENTS

|                                                   |     | Page |     |
| ABOUT THIS PROSPECTUS                             |     |      |   i |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |      | iii |
| PROSPECTUS SUMMARY                                |     |      |   1 |
| RISK FACTORS                                      |     |      |   5 |
| USE OF PROCEEDS                                   |     |      |   7 |
| PLAN OF DISTRIBUTION                              |     |      |   8 |
| LEGAL MATTERS                                     |     |      |  10 |
| EXPERTS                                           |     |      |  10 |
| WHERE YOU CAN FIND MORE INFORMATION               |     |      |  10 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE |     |      |  11 |

ABOUT THIS PROSPECTUS

This prospectus is part