Company: MTB-PJ
Filing Date: 2025-10-30
Form Type: 424B5
Source: 0001193125-25-257002
Chunk: 4

Company: M&T BANK CORP
Filing Date: 2025-10-30
Form: 424B5
Chunk 4
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 services industry, including industry conditions; |

| • |     | changes in interest rates, spreads on earning assets and interest-bearing liabilities, and interest rate 
 sensitivity;                                                                                             |

| • |     | prepayment speeds, loan originations, loan concentrations by type and industry, credit losses and market values 
 on loans, collateral securing loans, and other assets;                                                          |

| • |     | sources of liquidity; |

| • |     | levels of client deposits; |

| • |     | ability to contain costs and expenses; |

| • |     | changes in our credit ratings; |

| • |     | domestic or international political developments and other geopolitical events, including trade and tariff 
 policies and international conflicts and hostilities;                                                      |

| • |     | changes and trends in the securities markets; |

| • |     | common shares outstanding and common stock price volatility; |

| • |     | fair value of and number of stock-based compensation awards to be issued in future periods; |

| • |     | the impact of changes in market values on trust, brokerage, and investment management-related revenues; |

| • |     | federal, state or local legislation and/or regulations affecting the financial services industry, or M&T and 
 its subsidiaries individually or collectively, including tax policy;                                         |

| • |     | regulatory supervision and oversight, including monetary policy and capital requirements; |

| • |     | governmental and public policy changes; |

| • |     | political conditions, either nationally or in the states in which M&T and its subsidiaries do business; |

S-iii

| • |     | the initiation and outcome of potential, pending and future litigation, investigations and governmental 
 proceedings, including tax-related examinations and other matters;                                      |

| • |     | operational risk events, including loss resulting from fraud by employees or persons outside M&T and breaches 
 in data and cybersecurity;                                                                                    |

| • |     | changes in accounting policies or procedures as may be required by the Financial Accounting Standards Board, 
 regulatory agencies or legislation;                                                                          |

| • |     | increasing price, product and service competition by competitors, including new entrants; |

| • |     | technological developments and changes; |

| • |     | the ability to continue to introduce competitive new products and services on a timely, cost-effective basis; |

| • |     | the mix of products and services; |

| • |     | protection and validity of intellectual property rights; |

| • |     | reliance on large customers; |