Company: NCNA
Filing Date: 2025-04-24
Form Type: F-6
Source: 0001193805-25-000556
Chunk: 2

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-6
Chunk 2
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 accordingly, files certain
reports with, and submits certain reports to, the United States Securities and Exchange Commission (the “”).
These reports can be retrieved from the Commission’s internet website (www.sec.gov), and can be inspected and copied at the public
reference facilities maintained by the Commission at 100 F Street, N.E., Washington D.C. 20549.

<div align='center'>I-2</div>

The Prospectus consists of the proposed form
of American Depositary Receipt included as to the Form of Amended and Restated Deposit Agreement filed as Exhibit (a)(i)
to this Registration Statement on Form F-6 and is incorporated herein by reference.

<div align='center'>I-3

PART II

INFORMATION NOT REQUIRED IN PROSPECTUS</div>

| Item 3. | EXHIBITS |

| (a) | (i) Form of Amended and Restated Deposit Agreement, by and among NuCana plc (the “Company”),                          
 Citibank, N.A., as depositary (the “Depositary”), and all Holders and Beneficial Owners of American Depositary Shares 
 issued thereunder (“Deposit Agreement”). ___ Filed herewith as Exhibit (a)(i).                                        |

(ii) Amendment No. 1 to Deposit Agreement,
dated as of April 16, 2024, by and among the Company, the Depositary, and all Holders and Beneficial Owners of American Depositary Shares
issued thereunder. Filed herewith as Exhibit (a)(ii).

(iii) Deposit Agreement, dated as of October
2, 2017, by and among the Company, the Depositary, and all Holders and Beneficial Owners of American Depositary Shares issued thereunder.
Previously filed as Exhibit (a)(ii) to the Post-Effective Amendment No. 1 to the Registration Statement on Form F-6, Reg.
No. 333-220392, filed on March 27, 2024, and incorporated herein by reference.

| (b) | (i) At-the-Market Program Letter Agreement, dated as of April 6, 2020, by and between the Company and                      
 the Depositary. ___ Previously filed as Exhibit (b)(i) to the Post-Effective Amendment No. 1 to the Registration Statement 
 on Form F-6, Reg. No. 333-220392, filed on March 27, 2024, and incorporated herein by reference.                           |

(ii) Restricted