Company: RPTX
Filing Date: 2025-03-03
Form Type: S-8
Source: 0001193125-25-044105
Chunk: 2

Company: Repare Therapeutics Inc.
Filing Date: 2025-03-03
Form: S-8
Chunk 2
---
SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in City of Montréal, Province of Québec, Canada, on this 3rd day of March, 2025.

| REPARE THERAPEUTICS INC. |     |                                              |
| By:                      |     | /s/ Lloyd M. Segal                           |
|                          |     | Name: Lloyd M. Segal                         |
|                          |     | Title: President and Chief Executive Officer |

POWER OF ATTORNEY KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Lloyd M. Segal and Steve Forte, and each of them, as his or her true and lawful attorneys-in-factand agents, each with the full power of substitution, for him or her and in his or her name, place or stead, in any and all capacities, to sign any and all amendments to this Registration Statement (including post-effective amendments), and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-factand agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-factand agents, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

| Name                        
 /s/ Lloyd M. Segal          
 Lloyd M. Segal              
 /s/ Steve Forte             
 Steve Forte                 |     | Position                                                                      
 President, Chief Executive Officer and Director (Principal Executive Officer) 
 Executive Vice President, Chief Financial Officer                             
 (Principal Financial Officer and Principal Accounting Officer)                |     | Date          
 March 3, 2025 
 March 3, 2025 |
|:----------------------------|:----|:------------------------------------------------------------------------------|:----|:--------------|
|