Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 15

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 15
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 private issuer status. As long as we qualify as a foreign private issuer under the Exchange Act, we are exempt from certain provisions of the Exchange Act that are applicable to U.S. domestic public companies, including:

| • |     | the sections of the Exchange Act regulating the solicitation of proxies, consents or authorizations in 
 respect of a security registered under the Exchange Act;                                               |

| • |     | the sections of the Exchange Act requiring insiders to file public reports of their share ownership and   
 trading activities, and liability for insiders who profit from trades made in a short period of time; and |

| • |     | the rules under the Exchange Act requiring the filing with the SEC of quarterly reports on Form 10-Q containing unaudited financial and other specified information, or current reports on Form 8-K upon the occurrence of specified significant events. |

Foreign private issuers are also exempt from certain more stringent executive compensation disclosure rules. Thus, if we remain a foreign private issuer, we will continue to be exempt from the more stringent compensation disclosures required of companies that are not a foreign private issuer. As a consequence, we do not know if some investors will find our ADSs less attractive, which may result in a less active trading market for our ADSs or more volatility in the price of our ADSs.

4

THE OFFERING

| ADSs offered by us | Up to 12,497,768 ADSs, each representing twenty-five ordinary shares, based on an assumed combined public offering price of $0.5601 per ADS and accompanying Series A Warrant and Series B Warrant, which is the reported sale price of our ADSs 
 on The Nasdaq Capital Market on April 28, 2025.                                                                                                                                                                                                  |

| Pre-Funded Warrants offered by us | We are also offering to those purchasers, if any, whose purchase of the ADSs in this offering would result in such purchaser, together with its affiliates and certain related parties, beneficially owning more than 4.99% (or at the election of 
 the purchaser, 9.99%) of our outstanding ADSs immediately following consummation of this offering, the opportunity to purchase, if they so choose, Pre-Funded Warrants in lieu of the ADSs that would otherwise                                    
 result in ownership in excess of 4.99% (or 9.99%, as applicable) of our ADSs.                                                                                                                                                                      |

| The purchase price of each Pre-Funded Warrant and accompanying Warrants will equal the price