Company: NOTV
Filing Date: 2025-08-29
Form Type: S-3
Source: 0001628280-25-041413
Chunk: 48

Company: Inotiv, Inc.
Filing Date: 2025-08-29
Form: S-3
Chunk 48
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 and incorporated herein by reference. Such consolidated financial statements have been incorporated herein by reference in reliance upon such reports given on the authority of such firm as experts in accounting and auditing.

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$350,000,000</div>

#### Common Shares

#### Preferred Shares

#### Debt Securities

#### Share Purchase Contracts

#### Warrants

#### Rights

#### Units

### PROSPECTUS

#### , 2025

#### PROSPECTUS SUPPLEMENT

#### Up to $50,000,000

#### INOTIV, INC.

#### Common Shares
We have entered into an Open Market Sale Agreement SM (the “Sales Agreement”), with Jefferies LLC (“Jefferies”), relating to common shares offered by this prospectus supplement. In accordance with the terms of the Sales Agreement, we may offer and sell common shares having an aggregate offering price of up to $50.0 million from time to time through Jefferies acting as our agent.

Our common shares are listed on the Nasdaq Capital Market (“Nasdaq”), under the symbol “NOTV.” On August 26, 2025, the last reported sale price of our common shares as reported on the Nasdaq was $1.74 per share.

Sales of our common shares, if any, under this prospectus supplement and the accompanying prospectus may be made in transactions that are deemed to be “at the market offerings” as defined in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended, or the Securities Act, including sales made directly on Nasdaq or sales made into any other existing trading market of our common shares. Jefferies is not required to sell any specific amount of securities, but will act as our sales agent using commercially reasonable efforts consistent with its normal trading and sales practices, on mutually agreed terms between Jefferies and us. There is no arrangement for funds to be received in any escrow, trust or similar arrangement.

The compensation to Jefferies for sales of common shares sold pursuant to the Sales Agreement will be an amount up to 3.0% of the gross proceeds of any common shares sold under the Sales Agreement. See “

#### Plan of Distribution
” below for additional information regarding the compensation to be paid to Jefferies. In connection with the sale of the common shares on our behalf, Jefferies will be deemed to be an “underwriter” within the meaning of the Securities Act and the compensation of Jefferies will be