Company: DNLI
Filing Date: 2025-04-17
Form Type: DEF 14A
Source: 0001714899-25-000087
Chunk: 0

Company: Denali Therapeutics Inc.
Filing Date: 2025-04-17
Form: DEF 14A
Chunk 0
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### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549
<div align='center'>________________________________________</div>

#### SCHEDULE 14A

#### PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE

#### SECURITIES EXCHANGE ACT OF 1934
<div align='center'>________________________________________</div>

Filed by the Registrant x

Filed by a Party other than the Registrant ¨

Check the appropriate box:

| ¨ |     | Preliminary Proxy Statement                                                     |
| ¨ |     | Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) |
| x |     | Definitive Proxy Statement                                                      |
| ¨ |     | Definitive Additional Materials                                                 |
| ¨ |     | Soliciting Material Pursuant to §240.14a‑12                                     |

#### Denali Therapeutics Inc.
<div align='center'>(Name of Registrant as Specified In Its Charter)</div>

Payment of Filing Fee (Check all boxes that apply):

| x |     | No fee required                                                                                     |
| ¨ |     | Fee paid previously with preliminary materials                                                      |
| ¨ |     | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11 |

#### DENALI THERAPEUTICS INC.
Dear Stockholder:

I am pleased to invite you to attend the 2025 Annual Meeting of Stockholders (the “Annual Meeting”) of Denali Therapeutics Inc. (“Denali”), which will be held virtually via live webcast on June 3, 2025 at 10:00 a.m. Pacific Time. You can attend the virtual Annual Meeting via the Internet at www.virtualshareholdermeeting.com/DNLI2025, where you will be able to vote and submit questions electronically during the Annual Meeting.

The attached Notice of Annual Meeting of Stockholders and proxy statement contain details of the business to be conducted at the Annual Meeting.

Whether or not you attend the virtual Annual Meeting, it is important that your shares be represented and voted at the meeting. Therefore, I urge you to promptly vote and submit your proxy via the Internet, by phone or by mail. If you decide to attend the virtual Annual Meeting, you will be able to vote electronically, even if you have previously submitted your proxy.

On behalf of the board of