Company: WSBC
Filing Date: 2025-09-11
Form Type: 424B5
Source: 0001193125-25-201360
Chunk: 15

Company: WESBANCO INC
Filing Date: 2025-09-11
Form: 424B5
Chunk 15
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 and Computershare Trust Company, N.A. will serve jointly as depositary for the depositary shares. Computershare Trust Company, N.A. will serve as transfer agent and registrar for the Series B Preferred Stock and the depositary 
 shares.                                                                                                                                                                                                                                               |

| Calculation Agent | Wesbanco’s affiliate, Wesbanco Bank, will be the calculation agent for the Series B Preferred Stock. |

S-10

| Risk Factors | Investing in the depositary shares representing interests in the Series B Preferred Stock involves certain risks. Before investing in the depositary shares, you should carefully consider the information in this prospectus supplement and the      
 accompanying prospectus, including any information incorporated herein or in the accompanying prospectus by reference, and any final term sheet, if any describing the terms of the depositary shares or Series B Preferred Stock. In particular, you 
 should consider carefully the risk factors described in “Risk Factors” beginning on page S-12 of this prospectus supplement.                                                                                                                          |

S-11

RISK FACTORS

An investment in the depositary shares involves certain risks. Before making an investment decision, you should carefully consider the risks and uncertainties described below related to the offering as well as the risk factors and other information included in our Annual Report on Form 10-Kfor the fiscal year ended December 31, 2024, and in other documents that we subsequently filed with the SEC, all of which are incorporated by reference into this prospectus supplement and the accompanying prospectus. Additional risks and uncertainties of which management is not aware or that management currently deems immaterial may also impair our business operations. See also the discussion under the heading “Disclosure About Forward-Looking Statements.” This prospectus supplement and the accompanying prospectus are qualified in their entirety by these risk factors. If any of these risks actually occurs, our financial condition and results of operations could be materially and adversely affected. If this were to happen, the value of our securities could decline significantly, and you could lose all or part of your investment.

You are making an investment decision with regard to the depositary shares as well as the Series B Preferred Stock.

As described in this prospectus supplement and the accompanying prospectus, we are issuing
depositary shares representing fractional interests in shares of Series B Preferred Stock. Accordingly, the depositary will rely on the payments it receives on the Series B Preferred Stock to fund all payments on the depositary shares. You should
carefully review the information in this prospectus supplement and the accompanying prospectus