Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 4

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 4
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, certain of
the Selling Securityholders purchased shares of our Common Stock at prices that are well below the current trading price of our Common Stock. The

1,594,207 shares that may be resold into the public markets pursuant to this prospectus represent approximately 22.8% of the shares of our Common Stock outstanding as of March 31, 2025
(assuming the exercise of all outstanding SPAC Warrants for which underlying shares are registered for resale hereunder). The Selling Securityholders will be able to sell all of such shares and any SPAC Warrants registered for resale hereunder for
so long as the registration statement of which this prospectus forms a part is available for use.

The sale of all the securities being
offered in this prospectus could result in a significant decline in the public trading price of our securities. Despite such decline in the public trading price, some of the Selling Securityholders may still experience a positive rate of return on
the securities they purchased due to the difference in the purchase prices described above. Based on the closing price of our Common Stock of $5.43 and of our Public Warrants of $0.075 per Public Warrant, in each case on May 5, 2025, the Sponsors
may experience a potential profit of $5.19 per share of our Common Stock based on the Sponsor’s initial purchase price of $0.245 per share, and SCLX JV may experience a potential profit of up to $0.075 per SPAC Warrant given such warrants
were acquired by SCLX JV at no cost.

No underwriter or other person has been engaged to facilitate the sale of the shares of our Common
Stock or the SPAC Warrants in these offerings. The Selling Securityholders may be deemed to be “underwriters” within the meaning of the Securities Act of 1933, as amended (the “Securities Act”) of the Resale Shares and the
Private Warrants that they are offering pursuant to this prospectus. We will bear all costs, expenses and fees in connection with the registration of the shares of our Common Stock and SPAC Warrants hereunder. The Selling Securityholders will bear
all commissions and discounts, if any, attributable to their respective sales of the Resale Shares and the Private Warrants.

Our Common
Stock is listed on the Nasdaq Capital Market under the symbol “SCLX”. On May 13, 2025, the last reported sales price per share of our Common