Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 96

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 96
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 customary exceptions. The
Placement Agent may waive the terms of these lock-up agreements in its discretion.

Right of First Refusal

From the date of this prospectus until the eighteen (18) month anniversary from the closing of the offering, if we or any of our
subsidiaries decide to raise funds by means of a public offering, a private placement or any other capital-raising financing of equity, equity linked or debt securities with (i) gross proceeds equal to or exceeding $20,000,000, the Placement
Agent shall have the right to act as co-lead book-running manager with minimum economics of 35% of the gross proceeds of such placement, and (ii) gross proceeds less than $20,000,000 the Placement Agent
shall have the right to act as the lead book-running manager, underwriter or placement agent.

Tail

We have also agreed to pay the Placement Agent a tail fee equal to the 8% cash fee on total gross proceeds in an offering, if any investor, who
was introduced by the Placement Agent to us during the term of its engagement, provides us with capital in any public or private offering or other financing or capital raising transaction during the twelve (12) month period following expiration
or termination of our engagement of the Placement Agent.

Regulation M

The Placement Agent may be deemed to be an underwriter within the meaning of Section 2(a)(11) of the Securities Act, and any commissions
received by it and any profit realized on the resale of the securities sold by it while acting as principal might be deemed to be underwriting discounts or commissions under the Securities Act. As an underwriter, the Placement Agent would be
required to comply with the requirements of the Securities Act and the Exchange Act, including, without limitation, Rule 10b-5 and Regulation M under the Exchange Act. These rules and regulations may limit the
timing of purchases and sales of our securities by the Placement Agent acting as principal. Under these rules and regulations, the Placement Agent (i) may not engage in any stabilization activity in connection with our securities and
(ii) may not bid for or purchase any of our securities or attempt to induce any person to purchase any of our securities, other than as permitted under the Exchange Act, until it has completed its participation in the distribution.

67

Confidential Treatment Requested by Nucana plc

Pursuant to 17 C.F.R. Section 200.83

Indemnification

We have agreed to indemnify the