Company: JPC
Filing Date: 2025-06-12
Form Type: 424B3
Source: 0001999371-25-007638
Chunk: 190

Company: Nuveen Preferred & Income Opportunities Fund
Filing Date: 2025-06-12
Form: 424B3
Chunk 190
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 Securities & Income Opportunities Fund represented hereby will be voted as indicated or FOR the proposals if no choice is indicated.

| VOTE VIA THE INTERNET: www.proxy-direct.com 
 VOTE VIA THE TELEPHONE: 1-800-337-3503      |

<div align='center'>JPI_34517_050625

PLEASE SIGN, DATE ON THE REVERSE SIDE AND RETURN THE PROXY PROMPTLY USING THE ENCLOSED ENVELOPE.</div>

| xxxxxxxxxxxxxx | code |

<div align='center'>EVERY SHAREHOLDER’S VOTE IS IMPORTANT!

VOTE THIS PROXY CARD TODAY!

Important Notice Regarding the Availability of Proxy Materials for

Nuveen Preferred Securities & Income Opportunities Fund

for the Annual Meeting of Shareholders on July 25, 2025.

The Joint Proxy Statement/Prospectus for this meeting is available at:

https://www.nuveenproxy.com/Closed-End-Fund-Proxy-Information

IF YOU VOTE ON THE INTERNET OR BY TELEPHONE,

YOU NEED NOT RETURN THIS PROXY CARD

Please detach at perforation before mailing.</div>

THE BOARD OF TRUSTEES RECOMMENDS THAT YOU VOTE “FOR” THE PROPOSALS.

In their discretion, the proxy holders are authorized to vote upon such other matters as may properly come before the Annual Meeting or any adjournments or postponements thereof.

Properly executed proxies will be voted as specified. If no other specification is made, such shares will be voted “FOR” the proposals.

TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS SHOWN IN THIS EXAMPLE: X

| Proposals |

|     |                                                                                                                                              | FOR | AGAINST  | ABSTAIN |
| 1a. | To approve an                                                                                                                                
 Agreement and Plan of Merger pursuant to which Nuveen Preferred Securities & Income Opportunities Fund (“Target Fund”)                       
 would be merged with and into JPI Merger Sub, LLC, a Massachusetts limited liability company and wholly-owned subsidiary of Nuveen Preferred 
 & Income Opportunities Fund (“Acquiring Fund”), with the issued and outstanding common shares of the Target Fund being                       
 converted into newly issued common shares of the Acquiring Fund.                                                                             | ☐   | ☐        | ☐       |
| 2.  | Election of Board Members:                                                                                                                   | FOR | WITHHOLD | FOR ALL |
|     | Class I:                                                                                                                                     | ALL | ALL      | EXCEPT  |
|     | 01