Company: RNLXY
Filing Date: 2025-07-30
Form Type: 424B3
Source: 0001193805-25-001128
Chunk: 0

Company: Renalytix plc
Filing Date: 2025-07-30
Form: 424B3
Chunk 0
---
Filed Pursuant to Rule 424(b)(3)

Registration Statement on Form F-6

Registration No. 333-239729

<div align='center'>[FORM OF ADR]</div>

| Number        | CUSIP NUMBER:  _______                                                                                                           |
| _____________ |                                                                                                                                  |
|               | American Depositary Shares (each American Depositary Share representing the right to receive two (2) fully paid ordinary shares) |

<div align='center'>AMERICAN DEPOSITARY RECEIPT

for

AMERICAN DEPOSITARY SHARES

representing

DEPOSITED ordinary shares

of

Renalytixplc

(Incorporated under the laws of England and Wales)</div>

CITIBANK, N.A., a national
banking association organized and existing under the laws of the United States of America, as depositary (the “Depositary”),
hereby certifies that _____________is the owner of ______________ American Depositary Shares (hereinafter “ADS”) representing
deposited ordinary shares, including evidence of rights to receive such ordinary shares (the “Shares”), of Renalytix plc,
a public limited company incorporated under the laws of England and Wales (the “Company”). As of the date of issuance of this
ADR, each ADS represents the right to receive two (2) Shares deposited under the Deposit Agreement (as hereinafter defined) with the Custodian,
which at the date of issuance of this ADR is Citibank, N.A. (London) (the “Custodian”). The ADS(s)-to-Share(s) ratio is subject
to amendment as provided in Articles IV and VI of the Deposit Agreement. The Depositary’s Principal Office is located at 388 Greenwich
Street, New York, New York 10013, U.S.A.

(1) The Deposit Agreement. This American Depositary Receipt is one of an issue of American Depositary Receipts (“ADRs”),
all issued and to be issued upon the terms and conditions set forth in the Deposit Agreement, dated as of July 21, 2020 (as amended and
supplemented from time to time, the “Deposit Agreement”), by and among the Company, the Depositary, and all Holders and Beneficial
Owners from time to time of ADSs issued thereunder. The Deposit Agreement sets forth the rights and obligations of Holders and Beneficial
Owners of ADSs and the rights and duties of the Depositary in respect