Company: RPTX
Filing Date: 2025-03-03
Form Type: S-8
Source: 0001193125-25-044105
Chunk: 1

Company: Repare Therapeutics Inc.
Filing Date: 2025-03-03
Form: S-8
Chunk 1
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 indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

REGISTRATION OF ADDITIONAL SHARES PURSUANT TO GENERAL INSTRUCTION E Pursuant to General Instruction E of Form S-8,Repare Therapeutics Inc. (the “ Registrant”) is filing this Registration Statement with the Securities and Exchange Commission (the “ Commission”) to register (i) 2,125,535 additional common shares, no par value (the “ Common Shares”), of the Registrant under the 2020 Equity Incentive Plan (the “ 2020 Plan”), pursuant to the provisions of the 2020 Plan providing for an automatic increase in the number of Common Shares reserved and available for issuance under the 2020 Plan on January 1, 2025 and (ii) 425,107 additional Common Shares under the 2020 Employee Share Purchase Plan (the “ ESPP”), pursuant to the provisions of the ESPP providing for an automatic increase in the number of Common Shares reserved and available for issuance under the ESPP on January 1, 2025. In accordance with the instructional note to Part I of Form S-8as promulgated by the Commission, the information specified by Part I of the Form S-8has been omitted from this Registration Statement. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

| ITEM 3. | INCORPORATION OF DOCUMENTS BY REFERENCE |

The following documents filed by the Registrant with the Commission are incorporated by reference into this Registration Statement: (a) The contents of the Registrant’s Registration Statements on Form S-8(File Nos. 333-239400, 333-255048 , 333-263469, 333-270170and 333-277451) filed with the Commission on June 24, 2020, April 6, 2021, March 11, 2022, March 1, 2023 and February 28, 2024, respectively. (b) The Registrant’s Annual Report on Form 10-Kfor the fiscal year ended December 31, 2024, filed with the Commission on March 3, 2025. (c) The Registrant’s Current Report on Form 8-Kfiled with the Commission on February25, 2025. (d) The description of the