Company: PAYX
Filing Date: 2025-04-08
Form Type: 424B2
Source: 0001193125-25-075170
Chunk: 64

Company: PAYCHEX INC
Filing Date: 2025-04-08
Form: 424B2
Chunk 64
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| • |     | Expertise in HR and payroll with our technology backed by approximately 250 compliance experts and over 650 HR 
 business professionals;                                                                                        |

| • |     | Streamlined workforce management that combines technology with flexible, tech-enabled support options; |

| • |     | Modern, mobile, and intuitive user experience with self-service capabilities; |

| • |     | Scalable and customizable platform that allows clients the ability to add services as they grow; |

| • |     | Software as a service, or “SaaS”, delivery model that reduces total cost of ownership for our clients; 
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| • |     | Advanced data analytics and artificial intelligence capabilities powered by large data sets. |

We market our solutions through a combination of direct and virtual sales forces and ecommerce solutions supported by various digital lead generation and multi-channel marketing initiatives. Over 50% of our revenues are from solutions other than payroll processing. We were incorporated in Delaware in 1979. Our principal executive offices are located at 911 Panorama Trail South, Rochester, New York 14625-2396and our principal website address is www.paychex.com. Information on or accessible through our website is not incorporated into this prospectus. 4

RISK FACTORS

Investing in our securities involves risks. You should not purchase our securities unless you understand these investment risks. Before
purchasing any our securities, you should consider carefully the information in this prospectus and carefully read the discussion under “Part I – Item 1A. Risk Factors” in our Annual Report on Form
10-K for the year ended May 31, 2024, as such discussion may be amended or updated in other reports filed by us with the SEC, as well as the “Risk Factors” section in the applicable prospectus
supplement.

5

USE OF PROCEEDS

Unless otherwise indicated in a prospectus supplement, the net proceeds from the sale of the securities will be used for general corporate
purposes.

6

DESCRIPTION OF DEBT SECURITIES

We have summarized below general terms and conditions of the debt securities that we will offer and sell pursuant to this prospectus. When we
offer to sell a particular series of debt securities, we will describe the specific terms and conditions of the series in a prospectus supplement to this prospectus. We will also indicate in the applicable prospectus supplement whether the general
terms and conditions described in this prospectus apply to the series of debt securities. The terms and conditions