Company: CRNX
Filing Date: 2025-02-27
Form Type: S-8
Source: 0000950170-25-029087
Chunk: 1

Company: Crinetics Pharmaceuticals, Inc.
Filing Date: 2025-02-27
Form: S-8
Chunk 1
---
| Non-accelerated filer ¨   |     | Smaller reporting company ¨ |
|                           |     | Emerging growth company ¨   |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.¨

Proposed sales to take place as soon after the effective date of the Registration Statement as awards granted under the above-named plans are granted, exercised and/or distributed.

<div align='center'>EXPLANATORY NOTE</div>

This Registration Statement on Form S-8 is being filed for the purpose of registering an aggregate of 7,575,584 additional shares of common stock of Crinetics Pharmaceuticals, Inc. (the “Registrant”) issuable or which may become issuable pursuant to awards that may be granted under the Crinetics Pharmaceuticals, Inc. 2018 Incentive Award Plan (the “2018 Plan”) and the Crinetics Pharmaceuticals, Inc. 2018 Employee Stock Purchase Plan (the “2018 ESPP”), in each case, pursuant to the evergreen provisions of such plans, and the Crinetics Pharmaceuticals, Inc. 2021 Employment Inducement Incentive Award Plan (the “Inducement Plan”).

Pursuant to General Instruction E of Form S-8, the contents of the prior registration statements on Form S-8, File No. 333-226234, File No. 333-254883, File No. 333-264005, File No. 333-268328, File No. 333-270125, File No. 333-275366, and File No. 333-277484 previously filed with respect to the 2018 Plan, the 2018 ESPP and the Inducement Plan, are incorporated into this Registration Statement by reference to the extent not modified or superseded hereby or by any subsequently filed document, which is incorporated by reference herein or therein.

<div align='center'>PART II

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

In this Registration Statement, Crinetics Pharmaceuticals, Inc. is sometimes referred to as “Registrant,” “we,” “us” or “our.”</div>

Item 3. Incorporation of Documents by Reference

The Securities and Exchange Commission (“SEC”) allows us to “incorporate by reference” the information we file