Company: NCNA
Filing Date: 2025-08-01
Form Type: 6-K
Source: 0001193125-25-171672
Chunk: 1

Company: NuCana plc
Filing Date: 2025-08-01
Form: 6-K
Chunk 1
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Registration Statement on Form S-8(File No. 333-223476)and Registration Statement on Form S-8(File No. 333-248135). Forward Looking Statements This Form 6-Kcontains forward-looking statements. These statements are based on the current beliefs and expectations of the management of the Company and/or its affiliates. These forward-looking statements may include, but are not limited to, statements regarding the trading price of the Company’s ADSs. The Company’s estimates, projections and other forward-looking statements are based on management’s current assumptions and expectations of future events and trends, which affect or may affect the Company’s business, strategy, operations, or financial performance, and inherently involve significant known and unknown risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of many risks and uncertainties, which include, the impact of the ongoing, global political and economic conflicts on the Company’s business and the global economy; and general market conditions. Other factors that may cause actual results to differ from those expressed or implied in such forward-looking statements are described in the Company’s U.S. Securities and Exchange Commission (“SEC”) filings and reports (Commission File No. 001-38215),including the Company’s Annual Report on Form 20-Ffiled with the SEC on March 20, 2025 and the “Supplemental Risk Factors” filed with our Form 6-Ksfrom time to time. All statements other than statements of historical fact are forward-looking statements. The words “believe,” “may,” “might,” “could,” “will,” “aim,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “plan,” or the negative of those terms, and similar expressions that convey uncertainty of future events or outcomes are intended to identify estimates, projections, and other forward-looking statements. Estimates, projections, and other forward-looking statements speak only as of the date they were made, and, except to the extent required by law, the Company undertakes no obligation to update or review any estimate, projection, or forward-looking statement. Exhibits

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereto duly authorized.

| NuCana plc |     |                                            |
| By:        |     | /s/ Ian Webster                            |
| Name:      |     | Ian Webster