Company: SPRB
Filing Date: 2025-06-06
Form Type: DEFA14A
Source: 0000950170-25-083045
Chunk: 4

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-06-06
Form: DEFA14A
Chunk 4
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5 be replaced in its entirety with the following:

“To be considered for inclusion in next year’s proxy materials, your proposal must be submitted in writing by February 6, 2026, to 611 Gateway Boulevard, Suite 740, South San Francisco, California 94080, Attention: Corporate Secretary. If you wish to submit a proposal (including a director nomination) at the meeting that is not to be included in next year’s proxy materials, you must do so between March 24, 2026 and April 23, 2026. In addition, stockholders who intend to solicit proxies in support of director nominees other than the Company’s nominees must also comply with the additional requirements of Rule 14a-19(b). You are also advised to review the Company’s amended and restated bylaws, which contain additional requirements relating to advance notice of stockholder proposals and director nominations. The timely submission of a proposal (including a director nomination) does not guarantee its inclusion in the Company’s proxy materials.”

The response under “How many votes are needed to adopt or approve each proposal and how will votes be counted?” on page 6 be replaced in its entirety with the following:

“The following table summarizes the minimum vote needed to approve each proposal and the effect of abstentions and broker non-votes.

| ProposalNumber |     | Proposal Description          |     | Vote Required for Approval                                                                                                                                                                                                              |     | Voting Options                                                    |     | Effect ofAbstentions or Withhold Votes, as applicable |     | Effect ofBroker Non-Votes |
| 1              |     | Director Election Proposal    |     | Directors shall be elected by a plurality of the votes of the shares present in person, by remote communication, if applicable, or represented by proxy at the meeting and entitled to vote generally on the election of director.      |     | FOR or WITHHOLD with respect to each of the two director nominees |     | No effect                                             |     | No effect                 |
| 2              |     | Auditor Ratification Proposal |     | Affirmative vote of the majority of shares present in person, by remote communication, if applicable, or represented by proxy at the meeting and entitled to vote generally on the subject matter shall be the act of the stockholders. |     | FOR, AGAINST, or ABSTAIN                                          |     | Against                                               |     | Not applicable (1)        |
| 3              |     | Reverse Stock Split Proposal  |     | Affirmative vote of the majority of shares outstanding