Company: FITBI
Filing Date: 2025-11-05
Form Type: S-4
Source: 0001193125-25-267273
Chunk: 46

Company: FIFTH THIRD BANCORP
Filing Date: 2025-11-05
Form: S-4
Chunk 46
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 to serve as the president and chief executive officer of 
 Fifth Third;                                                                                                                                                                                                                                            |

| • |     | While the first merger will not constitute a change in control for purposes of Fifth Third’s compensation                                                                      
 and benefit plans, the existing severance plans with respect to Fifth Third’s executive officers will continue to govern each officer’s entitlement to severance benefits; and |

| • |     | Fifth Third may have discussions with certain of its executive officers regarding post-closing roles for such                                                                                                                                      
 executive officers within the combined company and may enter into agreements outlining separation entitlements for those officers who are not expected to stay with the combined company following the closing. As of the date of this joint proxy 
 statement/prospectus, no such arrangements with Fifth Third executive officers have been entered into.                                                                                                                                             |

The Fifth Third board of directors was aware of and considered these respective interests when deciding to adopt the merger agreement. For more information, see the section entitled “ The Mergers — Interests of Certain Fifth Third Directors and Executive Officers in the First Merger” beginning on page 107. Interests of Comerica’s Directors and Executive Officers in the First Merger (page 109) In considering the recommendation of the Comerica board of directors to vote to approve the Comerica merger agreement proposal, the Comerica compensation proposal and the Comerica adjournment proposal, Comerica stockholders should be aware that the directors and executive officers of Comerica may have interests in the mergers that are different from, or in addition to, the interests of Comerica stockholders generally and that may create potential conflicts of interest. These interests include, among others, the following:

| • |     | Each of Comerica’s executive officers holds unvested Comerica Stock Options, Comerica RSU Awards and 
 Comerica PSU Awards, which will be converted into the Assumed Options and Assumed                    |

24

| RSU Awards adjusted based on the exchange ratio, and otherwise subject to the same vesting terms and conditions (except that any performance goals are deemed earned based on the greater of target 
 and actual performance measured through the latest practicable date prior to the effective time);                                                                                                   |

| • |     | Comerica’s executive officers are party to change-in-control agreements that provide for severance payments                
 and benefits in connection with a termination of employment without cause or for good reason following the effective time; |

| • |     | Fifth Third entered into a letter agreement