Company: PRTA
Filing Date: 2025-03-28
Form Type: DEF 14A
Source: 0001559053-25-000017
Chunk: 58

Company: PROTHENA CORP PUBLIC LTD CO
Filing Date: 2025-03-28
Form: DEF 14A
Chunk 58
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 the total outstanding ordinary shares. The subsidiaries holding the shares reported herein are BlackRock Life Limited; BlackRock Advisors, LLC; Aperio Group, LLC; BlackRock (Netherlands) B.V.; BlackRock Institutional Trust Company, National Association; BlackRock Asset Management Ireland Limited;

| 2025 PROXY STATEMENT |     | 33 |

TABLE OF CONTENTS

| SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT |

BlackRock Financial Management, Inc.; BlackRock Japan Co., Ltd; BlackRock Asset Management Schweiz AG; BlackRock Investment Management, LLC; BlackRock Investment Management (UK) Limited; BlackRock Asset Management Canada Limited; BlackRock Investment Management (Australia) Limited; BlackRock Fund Advisors; and BlackRock Fund Managers Ltd. According to BlackRock’s most recent Form 13F filed with the SEC on February 7, 2025, reporting the securities it held as of December 31, 2024, BlackRock reported ownership of 4,122,376 ordinary shares (or 7.7% of our outstanding shares as of March 3, 2025). The address for the beneficial owner is 55 East 52nd Street, New York, New York 10055, USA.

(11) Includes 2,845 ordinary shares held by Dr. Selkoe and 1,363 ordinary shares held by Dr. Selkoe's spouse.

| Delinquent Section 16(a) Reports |

Section 16(a) of the Securities Exchange Act of 1934, as amended, requires our executive officers and directors, and persons who own more than 10% of our ordinary shares, to file reports of ownership and changes in ownership electronically with the SEC. Based on a review of such forms filed electronically with the SEC and our officers’ and directors’ written representations, we believe that each person who, at any time during fiscal year 2024, was an executive officer, director, or beneficial owner of more than 10% of our ordinary shares, complied with all filing requirements in a timely fashion, except for one Form 4 for Tran B. Nguyen reporting one transaction on April 8, 2020, which was filed on February 14, 2025.

| 34 |     | 2025 PROXY STATEMENT |

#### TABLE OF CONTENTS

### COMPENSATION DISCUSSION AND ANALYSIS
In this section we provide an explanation and analysis of the material elements of the compensation provided to our chief executive