Company: WSBC
Filing Date: 2025-09-11
Form Type: 424B5
Source: 0001193125-25-201360
Chunk: 106

Company: WESBANCO INC
Filing Date: 2025-09-11
Form: 424B5
Chunk 106
---
 Pennsylvania. Certain legal matters will be passed upon for any agents, dealers or underwriters by counsel named in the applicable
prospectus supplement. Denise Knouse-Snyder is a member of Phillips, Gardill, Kaiser & Altmeyer, PLLC and is also a member of the board of directors of Wesbanco. As of February 15, 2023, the members of Phillips, Gardill, Kaiser &
Altmeyer, PLLC beneficially owned 45,554 shares of Wesbanco common stock. Each of Phillips, Gardill, Kaiser & Altmeyer, PLLC and K&L Gates LLP from time to time performs legal services for Wesbanco.

EXPERTS

The consolidated financial statements of Wesbanco appearing in Wesbanco’s Annual Report (Form
10-K) for the year ended December 31, 2022, and the effectiveness of Wesbanco’s internal control over financial reporting as of December 31, 2022, have been audited by Ernst & Young
LLP, independent registered public accounting firm, as set forth in their reports thereon, included therein, and incorporated herein by reference. Such consolidated financial statements are incorporated herein by reference in reliance upon such
reports given on the authority of such firm as experts in accounting and auditing.

23

9,200,000 Depositary Shares

Each Representing a 1/40th Interest in a Share of

7.375% Fixed-Rate Reset Non-CumulativePerpetual Preferred Stock, Series B

PROSPECTUS SUPPLEMENT

Joint Book-Running Managers

Keefe Bruyette & Woods

A Stifel Company

RBC Capital Markets

Raymond James

Co-Manager

D.A. Davidson & Co.

September 10, 2025