Company: NCNA
Filing Date: 2025-07-16
Form Type: F-6 POS
Source: 0001193805-25-001028
Chunk: 2

Company: NuCana plc
Filing Date: 2025-07-16
Form: F-6 POS
Chunk 2
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 is subject to
the periodic reporting requirements of the United States Securities Exchange Act of 1934, as amended, and, accordingly, files certain
reports with, and submits certain reports to, the United States Securities and Exchange Commission (the “”).
These reports can be retrieved from the Commission’s internet website (www.sec.gov), and can be inspected and copied at the public
reference facilities maintained by the Commission at 100 F Street, N.E., Washington D.C. 20549.

<div align='center'>I-2</div>

The Prospectus consists of the proposed form
of American Depositary Receipt included as to the Form of Amendment No. 1 to the Amended and Restated Deposit Agreement
filed as Exhibit (a)(i) to this Post-Effective Amendment No. 1 to the Registration Statement on Form F-6 and is incorporated herein by
reference.

<div align='center'>I-3

PART II

INFORMATION NOT REQUIRED IN PROSPECTUS</div>

| Item 3. | EXHIBITS |

| (b) | (i) At-the-Market Program Letter Agreement, dated as of April 6, 2020, by and between the Company and                                  
 the Depositary. ___ Previously filed as Exhibit (b)(i) to the Post-Effective Amendment No. 1 to the Registration Statement             
 on Form F-6, Reg. No. 333-220392, filed on March 27, 2024, and incorporated herein by reference.                                       |
|     | (ii) Restricted ADS                                                                                                                    
 Letter Agreement, dated as of July 31, 2018, by and between the Company and the Depositary. ___ Previously filed as Exhibit            
 (b)(ii) to the Post-Effective Amendment No. 1 to the Registration Statement on Form F-6, Reg. No. 333-220392, filed on March 27, 2024, 
 and incorporated herein by reference.                                                                                                  |

| (c) | Every material contract relating to the deposited securities between the Depositary and the issuer of 
 the deposited securities in effect at any time within the last three years. ___ None.                 |

| (d) | Opinion of counsel for the Depositary as to the legality of the securities to be registered. ___                                      
 Previously filed as Exhibit (d) to Registration Statement on Form F-6 (Reg. No. 333-286737) with the Commission on April 24,