Company: IMRX
Filing Date: 2025-05-05
Form Type: S-8
Source: 0001104659-25-044519
Chunk: 0

Company: Immuneering Corp
Filing Date: 2025-05-05
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on May 5, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT

UNDER

THE SECURITIES ACT OF 1933

Immuneering Corporation

(Exact name of Registrant as specified in its charter)</div>

| Delaware                        |     | 26-1976972         |
| (State or other jurisdiction of 
 Incorporation or organization)  |     | -I.R.S. Employer   
 Identification No. |

<div align='center'>245 Main Street, Second Floor

Cambridge, Massachusetts 02142

(Address of principal executive offices) (Zip code)

Immuneering Corporation 2021 Incentive Award Plan

Immuneering Corporation 2021 Employee Stock Purchase Plan

Immuneering Corporation 2025 Employment Inducement Award Plan

(Full title of the plans)

Benjamin J. Zeskind, Ph.D.

Chief Executive Officer

Immuneering Corporation

245 Main Street, Second Floor

Cambridge, Massachusetts 02142

(Name and address of agent for service)

(617) 500-8080

(Telephone number, including area code, of agent for service)

With copies to:

Evan Smith, Esq.

Ellen Smiley, Esq.

Latham & Watkins LLP

1271 Avenue of the Americas

New York, New York 10020

(212) 906-1200</div>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting
company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,”
“smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer ¨ |     | Accelerated filer ¨         |
| Non-accelerated filer x   |     | Smaller reporting company x |
|                           |     | Emerging growth company x   |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for comply
with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B