Company: PFSA
Filing Date: 2025-10-29
Form Type: 424B3
Source: 0001213900-25-103174
Chunk: 91

Company: Profusa, Inc.
Filing Date: 2025-10-29
Form: 424B3
Chunk 91
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on favorable terms.

Moreover, the uncertainty surrounding
the potential exercise of march-in rights creates a challenging business environment. It introduces regulatory risks and can complicate
strategic planning and investment decisions for Profusa, as Profusa must navigate the possibility of government intervention in its intellectual
property rights.

The invocation of March-in
rights by the government could lead to increased competition, revenue reduction, loss of control over intellectual property, and heightened
regulatory complexities, all of which could have a negative impact on Profusa’s business operations and financial performance.

Additionally, government support
may have implications for Profusa’s right to license the inventions covered by these patents/applications. For example, generally
when granting an exclusive license, the licensee must ensure that the invention will be “manufactured substantially” within
the United States.

Obtaining and maintaining our patent protection depends on compliance with various procedural requirements, document submission, fee payment and other requirements imposed by government patent agencies and our patent protection could be reduced or eliminated for non-compliance with these requirements.

Periodic maintenance fees,
renewal fees, annuity fees and various other government fees on patents and applications will be due to be paid to the USPTO and various
government patent agencies outside of the United States over the lifetime of our owned patents and applications. The USPTO and various
foreign government agencies require compliance with several procedural, documentary, fee payment and other similar provisions during the
patent application process. In some cases, an inadvertent lapse can be cured by payment of a late fee or by other means in accordance
with the applicable rules. There are situations, however, in which non-compliance can result in abandonment or lapse of the patent or
patent application, resulting in a partial or complete loss of patent rights in the relevant jurisdiction. In such an event, potential
competitors might be able to enter the market with similar or identical products or technology, which could have a material adverse effect
on our business, financial condition, results of operations and prospects.

Patent terms may be inadequate to protect our competitive position on products or product candidates for an adequate amount of time.

Patents have a limited lifespan.
In most countries, if all maintenance fees are timely paid, the natural expiration of a patent is generally 20 years from its earliest
national or international (i.e., PCT) filing date. Various extensions may be available, but the life of a patent, and the protection it
affords, is limited. After patents expire, we may