Company: RCUS
Filing Date: 2025-02-25
Form Type: S-8
Source: 0001724521-25-000042
Chunk: 0

Company: Arcus Biosciences, Inc.
Filing Date: 2025-02-25
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on February 25, 2025</div>

#### Registration No. 333-

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### WASHINGTON, D.C. 20549

#### FORM S-8

### REGISTRATION STATEMENT

#### Under

#### The Securities Act of 1933

#### Arcus Biosciences, Inc.
<div align='center'>(Exact name of Registrant as specified in its charter)</div>

| Delaware                        |     | 47-3898435         |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -IRS Employer      
 Identification No. |

#### 3928 Point Eden Way

#### Hayward, CA 94545
<div align='center'>(Address of Principal Executive Offices, Zip Code)</div>

<div align='center'>ARCUS BIOSCIENCES, INC. 2018 EQUITY INCENTIVE PLAN

ARCUS BIOSCIENCES, INC. 2018 EMPLOYEE STOCK PURCHASE PLAN

(Full title of plan)</div>

#### Terry Rosen, Ph.D.

#### Chief Executive Officer

#### Arcus Biosciences, Inc.

#### 3928 Point Eden Way

#### Hayward, CA 94545
<div align='center'>(Name and address of agent for service)

(510) 694-6200

(Telephone number, including area code, of agent for service)

Please send copies of all communications to:</div>

#### Mark V. Roeder

#### John C. Williams

#### Latham & Watkins LLP

#### 140 Scott Drive

#### Menlo Park, CA 94025
<div align='center'>(650) 328-4600

(650) 328-4600</div>

Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer |     | ☒ |     | Accelerated filer         |     | ☐ |
| Non-accelerated filer   |     | ☐ |     | Smaller reporting company |     | ☐ |
|                         |     |