Company: EVGN
Filing Date: 2025-03-27
Form Type: 20-F
Source: 0001178913-25-001092
Chunk: 73

Company: Evogene Ltd.
Filing Date: 2025-03-27
Form: 20-F
Item: Item 4
Chunk 73
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 demonstrate an effect on the pest of focus. Hits displaying confirmed activity in the initial validation screens, enter the Hit-to-Lead process, which includes computational optimization and additional, more advanced, validation experiments.
 
In addition, these capabilities can also be used independently of each other to discover new Hits for known targets, to optimize an existing Hit to Lead and to optimize a commercial molecule.
 
Product Development Cycle
 
The product development cycle for ag-chemical products is generally comprised of several stages, described as follows:
 
Discovery stage
 

◾   Identification of Targets – identification and validation of vital targets or proteins that when inhibited (for instance by
                                         a chemical), lead to weed, insect or fungi death.                                     
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◾           Identification of Hits – screening of chemical compounds for the identification of candidate Hits that potentially inhibit        
    identified vital targets and are capable of achieving the desired impact on the weeds, insects or fungi of interest. The discovery process
                                  includes in-silico as well as biological screening and validation activities.                               
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◾          Hit-to-Lead process – Hits displaying confirmed activity in the initial validation screens will enter the Hit-to-Lead process,      
    including several optimization cycles, each constructed of compound design (in our case, focusing on computational optimization), synthesis
            of compounds and validation experiments. This stage ends with a ‘Lead’ compound, which is a validated Hit that has confirmed       
                                activity in advanced validation screens proving field translation in initial trials.                           
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Lead optimization
 

◾     In this stage, multiple field trials are conducted in diverse geographies, as well as greenhouse experiments on resistant weed biotypes  
    and on commercial crops, and the compound structure and formulation are finalized. Lead optimization also entails initial toxicology tests,
                              process engineering on the molecule and a significantly detailed cost of goods analysis.                         
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Pre-development stage
 

◾   In this stage, field trials to validate all commercial cases are conducted, including testing product mixtures, as well as additional
                                      safety trials. This stage ends with a ‘Pre-Development’ compound.                                  
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Development, Regulation & Registration stage
 

◾     In the final development phases, new chemical products are registered with the proper regulatory authorities in relevant territories  
    and then launched for commercialization. We expect that these last stages of development will be conducted by our collaboration partners
                                                    or licensees of our product candidates.                                                 
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