Company: CERO
Filing Date: 2025-10-23
Form Type: 424B3
Source: 0001213900-25-101651
Chunk: 10

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-10-23
Form: 424B3
Chunk 10
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01 with respect
to the issuance of the shares of Series E Preferred Stock pursuant to the Securities Purchase Agreement is incorporated herein by reference.
All such securities will not be registered under the Securities Act in reliance on the exemption from registration provided by Section
4(a)(2) of the Securities Act and/or Rule 506 of Regulation D promulgated thereunder, or under any state securities laws. The Company
relied on this exemption from registration in entering into the Securities Purchase Agreement and the Company will rely upon this exemption
from registration in issuing such securities based in part on representations made by the PIPE Investors. The securities may not be offered
or sold in the United States absent registration or an applicable exemption from registration requirements. Neither this Current Report
on Form 8-K, nor the exhibits attached hereto, is an offer to sell or the solicitation of an offer to buy the securities described herein.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

The following exhibits are being filed herewith:

| Exhibit No. 
 3.1†        
 10.1*†      |     | Document                                                                                                                                          
 Form of Certificate of Designation of Preferences, Rights and Limitations of the Series E Convertible Preferred Stock.                            
 Securities Purchase Agreement, dated as of October 14, 2025, by and between CERo Therapeutics Holdings, Inc. and the investors signatory thereto. |
|:------------|:----|:--------------------------------------------------------------------------------------------------------------------------------------------------|
| 10.2*       |     | Form of Registration Rights Agreement by and between CERo Therapeutics Holdings, Inc. and the investors signatory thereto.                        |
| 104         |     | Cover Page Interactive Data File (embedded within the Inline XBRL document).                                                                      |

| * | Schedules and exhibits have been omitted pursuant to Item                                                             
 601(a)(5) of Regulation S-K. A copy of any omitted schedule and/or exhibit will be furnished to the SEC upon request. |

| † | Certain portions of this document that constitute confidential                
 information have been redacted pursuant to Item 601(b)(10) of Regulation S-K. |

<div align='center'>4</div>

Forward-Looking Statements

This Current Report on Form 8-K contains statements
that are forward-looking and as such are not historical facts. This includes, without limitation, statements regarding (i) the expected
cash proceeds of the Private Placement and the timing of the closing of the Private Placement, and (