Company: DMAC
Filing Date: 2025-11-13
Form Type: S-8
Source: 0001437749-25-034866
Chunk: 0

Company: DiaMedica Therapeutics Inc.
Filing Date: 2025-11-13
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on November 13, 2025.</div>

Registration No.

### UNITED STATESSECURITIES AND EXCHANGE COMMISSION
<div align='center'>Washington, D. C. 20549

Form S-8

REGISTRATION STATEMENT UNDER THE
SECURITIES ACT OF 1933</div>

| DIAMEDICA THERAPEUTICS INC.                            |
| (Exact Name of Registrant as Specified in its Charter) |

| British Columbia, Canada                 |     |     Not Applicable |
| (State or other jurisdiction of          
 incorporation or organization)           |     |   -I.R.S. Employer 
 Identification No. |
| 301 Carlson Parkway, Suite 210           
 Minneapolis, Minnesota                   |     |              55305 |
| (Address of Principal Executive Offices) |     |          -Zip Code |

<div align='center'>DiaMedica Therapeutics Inc.
2021 Employment Inducement Plan

(Full Title of the Plan)</div>

| Rick Pauls                              
 President and Chief Executive Officer   
 DiaMedica Therapeutics Inc.             
 301 Carlson Parkway, Suite 210          
 Minneapolis, Minnesota 55305            
 (Name and Address of Agent for Service) |

<div align='center'>Telephone number, including area code, of agent for service:(763) 496-5454

Copies to:</div>

| Jonathan R. Zimmerman             
 Joshua L. Colburn                 
 Faegre Drinker Biddle & Reath LLP 
 2200 Wells Fargo Center           
 90 South Seventh Street           
 Minneapolis, Minnesota 55402‑3901 | Keith Inman               
 Pushor Mitchell LLP       
 301 – 1665 Ellis Street   
 Kelowna, British Columbia 
 Canada                    
 V1Y 2B3                   |

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non‑accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large Accelerated Filer ☐ | Accelerated Filer ☐         |
| Non‑accelerated Filer ☑   | Smaller Reporting Company ☑ |
|                           | Emerging Growth Company ☐   |

If an emerging growth company, indicate by check mark if