Company: SNY
Filing Date: 2025-10-29
Form Type: 424B5
Source: 0001193125-25-255563
Chunk: 32

Company: Sanofi
Filing Date: 2025-10-29
Form: 424B5
Chunk 32
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,000 3.750% Notes due 2027 (the “2027 fixed rate notes”), (iv) the $400,000,000 3.800% Notes due 2028 (the “2028 fixed rate notes”), and (v) the $1,200,000,000 4.200% Notes due 2032 (the
“2032 fixed rate notes” and, together with the 2027 fixed rate notes and the 2028 fixed rate notes, the “Fixed Rate Notes”). In this section, we refer to the Floating Rate Notes and the Fixed Rate Notes collectively as the
“Notes.”

Fixed Rate Notes

The 2027 fixed rate notes, 2028 fixed rate notes and the 2032 fixed rate notes will mature at par on November 3, 2027, November 3,
2028 and November 3, 2032, respectively.

The 2027 fixed rate notes will bear interest from November 3, 2025, at a fixed rate of
3.750% per annum. The 2028 fixed rate notes will bear interest from November 3, 2025, at a fixed rate of 3.800% per annum. The 2032 fixed rate notes will bear interest from November 3, 2025, at a fixed rate of 4.200% per annum. Interest on

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the Fixed Rate Notes will be payable on May 3 and November 3 of each year (each, an “Interest Payment Date”), commencing on May 3, 2026, to the holders in whose name
the Fixed Rate Notes are registered at the close of business on April 18 and October 19, as applicable (which are the regular record dates), immediately preceding the related Interest Payment Date.

We will pay interest on the Fixed Rate Notes on the Interest Payment Dates stated above and at maturity. Each payment of interest due on an
Interest Payment Date or at maturity or redemption will include interest accrued from and including the last date to which interest has been paid or made available for payment, or from the issue date, if none has been paid or made available for
payment, to but excluding the relevant payment date. We will compute interest on the Notes on the basis of a 360-day year of twelve 30-day months.

If any payment is due on the Fixed Rate Notes on a day that is not a business day, we will make the payment on the day that is the