Company: FITBI
Filing Date: 2025-11-05
Form Type: S-4
Source: 0001193125-25-267273
Chunk: 408

Company: FIFTH THIRD BANCORP
Filing Date: 2025-11-05
Form: S-4
Chunk 408
---
 is against public policy as expressed in the Securities Act of 1933 and is therefore unenforceable. In the event a claim of indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or
paid by a director, officer or controlling person of the Registrant in a successful defense of any action, suit or proceeding) is asserted by such director, officer, or controlling person in connection with the securities being registered, the
Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the
Securities Act of 1933 and will be governed by the final adjudication of such issue.

II-7

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cincinnati, State of Ohio, on November 5, 2025.

| FIFTH THIRD BANCORP |     |                                                        |
| (Registrant)        |     |                                                        |
| By:                 |     | /s/ Timothy N. Spence                                  |
|                     |     | Name: Timothy N. Spence                                |
|                     |     | Title: Chairman, Chief Executive Officer and President |

BE IT KNOWN BY THESE PRESENT: Each of the undersigned directors and officers has made, constituted, and appointed, and does hereby make, constitute, and appoint Timothy N. Spence and Christian Gonzalez, and each of them, with full power of substitution, his or her true and lawful attorneys-in-fact,for him or her and in his or her name, place and stead to affix his or her signature as director or officer or both, as the case may be, of the registrant, to any and all registration statements and amendments thereto (including post-effective amendments) and to file the same, with all exhibits thereto, and other documents in connection therewith, relating to the registration under the Securities Act of 1933 of the shares of common stock, without par value, and preferred stock, no par value, and depositary shares in respect thereof, of Fifth Third Bancorp issuable in connection with the acquisition of Comerica Incorporated by Fifth Third Bancorp, and to file with the Securities and Exchange Commission, granting unto such attorney-in-fact