Company: OSRH
Filing Date: 2025-06-27
Form Type: 424B3
Source: 0001213900-25-058551
Chunk: 0

Company: OSR Holdings, Inc.
Filing Date: 2025-06-27
Form: 424B3
Chunk 0
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Filed Pursuant to Rule 424(b)(3)

Registration No. 333-287626

PROSPECTUS SUPPLEMENT NO.1

(to Prospectus dated June 20, 2025)

<div align='center'>OSR Holdings, Inc.

Up to 15,410,000 Shares of Common Stock</div>

This prospectus supplement (this “Supplement”)
is being filed to update and supplement the information contained in the prospectus dated June 20, 2025 (as supplemented or amended from
time to time, the “Prospectus”). Each of the Prospectus and this Supplement form a part of our Registration Statement on Form
S-1 (Registration No. 333-287626) declared effective by the Securities and Exchange Commission (the “SEC”) on June 17,
2025 (the “Registration Statement”).

This Supplement updates and supplements the information
in the Registration Statement and Prospectus, and is not complete without, and may not be delivered or utilized except in combination
with, the Registration Statement and the Prospectus, including any amendments or supplements thereto. This Supplement should be read in
conjunction with the Registration Statement and the Prospectus and if there is any inconsistency between the information in the Registration
Statement or Prospectus and this Supplement, you should rely on the information in this Supplement.

We are not selling any securities under the Prospectus
or this Supplement and will not receive any of the proceeds from the sale of shares of common stock by White Lion Capital LLC dba White
Lion GBM Innovation Fund (“White Lion” or the “Selling Stockholder”). We may receive up to $83.9 million in aggregate
gross proceeds from White Lion in connection with sales of our securities to White Lion pursuant to the Issuance Agreements, which include
that certain common stock equity line agreement, consisting of a Common Stock Purchase Agreement and a Registration Rights Agreement,
both dated as of February 25, 2025 and amended and restated as of May 6, 2025 (collectively, the “ELOC Agreement”), the Common
Stock Purchase Warrant dated May 6, 2025 (the “Warrant Agreement”), and the Note Purchase Agreement dated May 6, 2025 (the
“Note Purchase Agreement”), each by and between the OSR Holdings, Inc. (the “Company”) and White Lion. However,
the actual proceeds from White Lion may be less than this amount depending on the number of shares of