Company: BDRX
Filing Date: 2025-01-17
Form Type: F-1
Source: 0001214659-25-000922
Chunk: 314

Company: Biodexa Pharmaceuticals Plc
Filing Date: 2025-01-17
Form: F-1
Chunk 314
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 may be closed at any time or from time to time, when deemed expedient
by the depositary.

The depositary will maintain
facilities for the delivery and receipt of ADRs.

Appointment

In the Deposit Agreement,
each registered holder of ADRs and each beneficial owner, upon acceptance of any Depositary Shares or ADRs (or any interest in any of
them) issued in accordance with the terms and conditions of the Deposit Agreement will be deemed for all purposes to:

| · | be a party to and bound by the terms of the Deposit Agreement and the applicable ADR or ADRs, |

| · | appoint the depositary its attorney-in-fact, with full power to delegate, to act on its behalf and to                                      
 take any and all actions contemplated in the Deposit Agreement and the applicable ADR or ADRs, to adopt any and all procedures necessary   
 to comply with applicable laws and to take such action as the depositary in its sole discretion may deem necessary or appropriate to carry 
 out the purposes of the Deposit Agreement and the applicable ADR and ADRs, the taking of such actions to be the conclusive determinant     
 of the necessity and appropriateness thereof; and                                                                                          |

| · | acknowledge and agree that (i) nothing in the Deposit Agreement or any ADR shall give rise to a partnership                                  
 or joint venture among the parties thereto, nor establish a fiduciary or similar relationship among such parties, (ii) the depositary,       
 its divisions, branches and affiliates, and their respective agents, may from time to time be in the possession of non-public information    
 about us, ADR holders, beneficial owners and/or their respective affiliates, (iii) the depositary and its divisions, branches and affiliates 
 may at any time have multiple banking relationships with us, ADR holders, beneficial owners and/or the affiliates of any of them, (iv)       
 the depositary and its divisions, branches and affiliates may, from time to time, be engaged in transactions in which parties adverse        
 to us, ADR holders, or beneficial owners may have interests, (v) nothing contained in the Deposit Agreement or any ADR(s) shall (A) preclude 
 the depositary or any of its divisions, branches or affiliates from engaging in any such transactions or establishing or maintaining any     
 such relationships, or (B) obligate the depositary or any of its divisions, branches or affiliates to disclose any such transactions or      
 relationships or to account for any