Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 53

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 53
---
 by the plaintiff to obtain the action the plaintiff                                          
 desires from the directors and the reasons for the plaintiff’s failure to obtain the action; or                                            
 •  state the reasons for not making the effort.                                                                                            
 Additionally, the plaintiff must remain a stockholder through the duration of the                                                          
 derivative suit. The action will not be dismissed or compromised without the approval of the Delaware Court of Chancery.                   |

37

DESCRIPTION OF AMERICAN DEPOSITARY SHARES

American Depositary Shares

Citibank has
agreed to act as the depositary for the ADSs. Citibank’s depositary offices are located at 388 Greenwich Street, New York, New York 10013. ADSs represent ownership interests in securities that are on deposit with the depositary. ADSs may
be represented by certificates that are commonly known as American Depositary Receipts, or ADRs. The depositary typically appoints a custodian to safekeep the securities on deposit. In this case, the custodian is Citibank, N.A., London Branch.

We have appointed Citibank as depositary pursuant to a deposit agreement dated October 2, 2017, as amended on April 16, 2024, or the deposit
agreement. A copy of the deposit agreement is on file with the SEC under cover of the Post-Effective Amendment No. 1 to the registration statement on Form F-6, as filed with the SEC on
March 27, 2024. You may obtain a copy of the deposit agreement from the SEC’s website (www.sec.gov).

We are providing
you with a summary description of the material terms of the ADSs and of your material rights as an owner of ADSs. Please remember that summaries by their nature lack the precision of the information summarized and that the rights and obligations of
an owner of ADSs will be determined by reference to the terms of the deposit agreement and not by this summary. We urge you to review the deposit agreement in its entirety. The portions of this summary description that are italicized describe
matters that may be relevant to the ownership of ADSs but that may not be contained in the deposit agreement.

Each ADS represents the
right to receive, and to exercise the beneficial ownership interests in, twenty-five ordinary shares that is on deposit with the depositary or custodian. An ADS also represents the right to receive, and to exercise the beneficial interests in, any
other property received by the depositary or the