Company: INTS
Filing Date: 2025-06-27
Form Type: S-8
Source: 0001567264-25-000060
Chunk: 0

Company: INTENSITY THERAPEUTICS, INC.
Filing Date: 2025-06-27
Form: S-8
Chunk 0
---
<div align='center'>As filed with the Securities and Exchange Commission on June 27, 2025</div>

#### Registration No. 333-

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

#### FORM S-8

### REGISTRATION STATEMENT

#### UNDER

#### THE SECURITIES ACT OF 1933

#### Intensity Therapeutics, Inc.
<div align='center'>(Exact name of registrant as specified in its charter)</div>

| Delaware                        |     | 46-1488089         |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -I.R.S. Employer   
 Identification No. |

#### 1 Enterprise Drive, Suite 430

#### Shelton, CT 06484

#### Telephone: (203) 221-7381
<div align='center'>(Address of principal executive offices) (Zip code)

Intensity Therapeutics, Inc. 2024 Employee Stock Purchase Plan

Intensity Therapeutics, Inc. 2021 Stock Incentive Plan

(Full title of the plans)</div>

#### Lewis H. Bender

#### Chief Executive Officer

#### 1 Enterprise Drive, Suite 430

#### Shelton, CT 06484
<div align='center'>(Name and address of agent for service)

(203) 221-7381

(Telephone number, including area code, of agent for service)

Copy to:</div>

#### Jeffrey P. Schultz
<div align='center'>Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.</div>

#### 919 Third Avenue

#### New York, New York 10022
<div align='center'>(212) 935-3000</div>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer |     | o |     | Accelerated filer         |     | o |
| Non-accelerated filer   |     | x |     | Smaller reporting company |     | x |
|                         |     |   |     | Emerging