Company: SCLXW
Filing Date: 2025-10-02
Form Type: 424B3
Source: 0001193125-25-227263
Chunk: 6

Company: Scilex Holding Co
Filing Date: 2025-10-02
Form: 424B3
Chunk 6
---
 The Registrant agrees to furnish a copy of all omitted exhibits and schedules to the SEC upon its request.

<div align='center'>3</div>

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

|                       | SCILEX HOLDING COMPANY |                         |
|                       | By:                    | /s/ Stephen Ma          |
|                       | Name:                  | Stephen Ma              |
| Date: October 1, 2025 | Title:                 | Chief Financial Officer |

<div align='center'>4</div>

Exhibit 10.1

<div align='center'>WARRANT EXERCISE AGREEMENT</div>

This Warrant Exercise Agreement (this “Agreement”) is dated as of September 30, 2025 (the “Effective Date”), among Scilex Holding Company, a Delaware corporation with offices located at 960 San Antonio Road, Palo Alto, CA 94303 (the “Company”) and the undersigned investor (the “Holder”). Capitalized terms not defined herein shall have the meaning as set forth in the New Warrant (as defined below).

Whereas, prior to the date hereof, pursuant to that certain Securities Purchase Agreement, dated December 11, 2024 (the “December 2024 Securities Purchase Agreement”), by and among the Company and the investors party thereto (including the Holder), among other things, the Company issued to the Holder certain warrants the (“Existing Warrants”) to purchase shares (the “Existing Warrant Shares”) of Common Stock, par value $0.0001 per share (the “Common Stock”);

WHEREAS, the Company desires that the Holder exercise, in full, the remaining unexercised Existing Warrants into such aggregate number of Existing Warrant Shares as set forth on the signature page of the Holder attached hereto;

WHEREAS, prior to the date hereof, the Company issued a Senior Secured Convertible Note (the “Tranche B Note”) to the Holder pursuant to that certain Securities Purchase Agreement, dated as of October 7, 2024 (the “October 2024 Securities Purchase Agreement”), by and among the Company and the investors party thereto (including the Holder);

WHEREAS, pursuant to the amortization schedule included in the Tranche B Note, the Company is required to pay an amortization payment to the Holder on October 1, 202