Company: BIVIW
Filing Date: 2025-07-11
Form Type: S-1/A
Source: 0001520138-25-000205
Chunk: 88

Company: BIOVIE INC.
Filing Date: 2025-07-11
Form: S-1/A
Chunk 88
---
 to agree to disclose and assign
to us all inventions conceived during the workday, using our property, or which relate to our business. Despite any measures taken to
protect our intellectual property (IP), unauthorized parties may attempt to copy aspects of our products or to obtain and use information
that we regard as proprietary.

BIV201 was awarded Orphan Drug Designations in
the U.S. for the treatment of hepatorenal syndrome on November 21, 2018 and treatment of ascites due to all etiologies except cancer on
September 8, 2016. We also filed a PCT application covering our novel liquid formulations of terlipressin (international patent application
PCT/US2020/034269, published as WO2020/237170) and are seeking patent protection in U.S., Europe, China, Japan and other jurisdictions.
To date patents have been granted in India (Patent No. 540813) and Chile (Patent No. 68965). Also, we own U.S. Patent 11,364,277, and
European patent EP3347032, which is directed to a method of treating ascites with BIV201, and we are pursuing additional patent coverage
in U.S., Japan, Europe, and China.

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Bezisterim (NE3107) and related compounds

As of July 11, 2025, we have thirteen (13) issued
U.S. patents, five (5) pending U.S. patent applications, three (3) pending U.S. PCT applications, four (4) issued foreign patents and
eight (8) pending foreign patent applications directed to protecting NE3107 and related compounds and methods of making and using thereof.
The U.S. patents and pending patent applications and their projected expiration dates are provided below.

| Title                                                                       |     | Patent Application |     |            | Patent |     | Projected Expiration |           |
|                                                                             |     | Number             |     |            | Number |     | Date                 |           |
| Unsaturated Steroid Compounds                                               |     | 13/030,326         |     |  8,586,770 |        |     |                      | 6/2/2026  |
| Solid State Forms of a Pharmaceutical                                       |     | 12/418,559         |     |  8,252,947 | *      |     |                      | 4