Company: PSTV
Filing Date: 2025-03-14
Form Type: PRE 14A
Source: 0001140361-25-008857
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Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-03-14
Form: PRE 14A
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

| ☑ | Filed by the Registrant |

| ☐ | Filed by a party other than the Registrant |

CHECK THE APPROPRIATE BOX:

| ☑ | Preliminary Proxy Statement |

| ☐ | Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) |

| ☐ | Definitive Proxy Statement |

| ☐ | Definitive Additional Materials |

| ☐ | Soliciting Material under §240.14a-12 |

PLUS THERAPEUTICS, INC. (Name of Registrant as Specified In Its Charter) (Name of Person(s) Filing Proxy Statement, if other than the Registrant) PAYMENT OF FILING FEE (CHECK ALL BOXES THAT APPLY):

| ☑ | No fee required |

| ☐ | Fee paid previously with preliminary materials |

| ☐ | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11 |

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### PRELIMINARY PROXY STATEMENT - SUBJECT TO COMPLETION
**In accordance with Rule 14a-6(d) under Regulation 14A of the Securities Exchange Act of 1934, as amended, please be advised that Plus Therapeutics, Inc. intends to release definitive copies of this Proxy Statement and Proxy on or about March [•], 2025.**

#### Notice of Special Meeting of Stockholders

#### and Proxy Statement

#### Virtual Special Meeting
<div align='center'>[Day], April [•], 2025

[9:00 a.m. Eastern Time]

www.virtualshareholdermeeting.com/PSTV2025

For further information, please contact Plus Therapeutics’ Investor Relations at https://ir.plustherapeutics.com/.</div>

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PLUS THERAPEUTICS, INC. 2710 Reed Rd, Suite 160, Houston, TX 77051 NOTICE OF SPECIAL MEETING OF STOCKHOLDERS To Be Held on [], 2025

| MEETING LOCATION:                          |
| www.virtualshareholdermeeting.com/PSTV2025 |

Dear Plus Therapeutics, Inc. Stockholder