Company: AZN
Filing Date: 2025-05-01
Form Type: 6-K
Source: 0001654954-25-004975
Chunk: 0

Company: ASTRAZENECA PLC
Filing Date: 2025-05-01
Form: 6-K
Chunk 0
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#### FORM 6-K
<div align='center'>SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Report of Foreign Issuer

Pursuant to Rule 13a-16 or 15d-16 of

the Securities Exchange Act of 1934

For the month of May 2025

Commission File Number: 001-11960</div>

#### AstraZeneca PLC
<div align='center'>1 Francis Crick Avenue

Cambridge Biomedical Campus

Cambridge CB2 0AA

United Kingdom

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F X Form 40-F __

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ______

Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes __ No X

If “Yes” is marked, indicate below the file number assigned to the Registrant in connection with Rule 12g3-2(b): 82-_____________</div>

#### AstraZeneca PLC
<div align='center'>INDEX TO EXHIBITS</div>

#### 1.

#### Director/PDMR Shareholding
1 May 2025

<div align='center'>**Transaction by Person Discharging Managerial Responsibilities**</div>

AstraZeneca PLC (the Company) announces that it was notified on 1 May 2025 that Karen Knudsen, Non-Executive Director, purchased 1,400 of the Company's American Depositary Shares (ADSs) on 30 April 2025, as set out below. Two ADSs are equivalent to one of the Company's ordinary shares of $0.25 each.

| PDMR          | Position               | Nature of the transaction | Quantity | Price per ADS |
| Karen Knudsen | Non-Executive Director | Purchase of ADSs          |    1,400 |       $71.655 |

Further details are set out in the attached notification, made in