Company: APM
Filing Date: 2025-04-30
Form Type: 20-F
Source: 0001213900-25-037669
Chunk: 148

Company: Aptorum Group Ltd
Filing Date: 2025-04-30
Form: 20-F
Item: Item 4
Chunk 148
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  human and animal tissues;  

  infectious materials;  

  dressings; and  

  such other wastes as specified by the Director of the Environmental Protection Department (“ EPD”) of Hong Kong.  

Given the research works in
our R& D Center may produce used or contaminated sharps such as syringes and needles as well as dressings, we are subject to WDO, WDR
and the Code of Practice.

Rest of the World Regulation

For other countries in the
world, the requirements governing the conduct of clinical trials, medical product licensing, pricing and reimbursement vary from country
to country. In all cases if clinical trials are required, they must be conducted in accordance with cGCP requirements and the applicable
regulatory requirements and the ethical principles having their origin in the Declaration of Helsinki.

If we fail to comply with
applicable foreign regulatory requirements, we may be subject to, among other things, fines, suspension or withdrawal of regulatory approvals,
product recalls, seizure of products, operating restrictions and criminal prosecution.

C. Our Structure

See “ Item 4. Information
on the Company - A. History and Development of the Company.”

D. Property, plants and equipment

We have an operating lease
for laboratory in Hong Kong, with 2,021 square feet lab space under a lease that commenced in March 2020, renewed in March 2023 and expires
in March 2026. The monthly rent ranges from $6,348 to $9,068. Payments under operating leases are expensed on a straight-line basis over
the periods of the respective leases, and the terms of the leases do not contain contingent rent and renewal or purchase options.

We believe our current facilities
are sufficient to meet our needs.

Item 4A. UNRESOLVED STAFF COMMENTS