Company: WSBC
Filing Date: 2025-09-11
Form Type: 424B5
Source: 0001193125-25-201360
Chunk: 1

Company: WESBANCO INC
Filing Date: 2025-09-11
Form: 424B5
Chunk 1
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 other restrictions as described elsewhere in this prospectus supplement.

Dividends on the Series B Preferred Stock will not be cumulative. This means that if we do not declare a dividend on Series B Preferred Stock
for any dividend payment date, then that dividend will not accrue or be payable. In other words, if we have not declared a dividend before the dividend payment date for any dividend period, we will have no obligation to pay dividends for that
dividend period, whether or not dividends on the Series B Preferred Stock are declared for any future dividend period.

We may, at our
option and subject to any required regulatory approvals, redeem the Series B Preferred Stock (i) in whole or in part, from time to time, on any dividend payment date on or after October 1, 2030 or (ii) in whole, but not in part, at
any time within 90 days following a “regulatory capital treatment event,” as defined herein, in each case at a redemption price equal to $1,000 per share (equivalent to $25 per depositary share), plus any declared and unpaid dividends.

The Series B Preferred Stock will not have voting rights, except as set forth under “Description of the Series B Preferred
Stock — Voting Rights” beginning on page S-30.

Currently no public market exists for
the depositary shares. Application will be made to list the depositary shares on the Nasdaq Global Select Market (“Nasdaq”) under the symbol “WSBCPB”. If the application is approved, trading of the depositary shares on the
Nasdaq is expected to commence within a 30-day period after the initial delivery of the depositary shares.

Neither the Series B Preferred Stock nor the depositary shares are savings accounts, deposits or other obligations of any of our bank or non-banksubsidiaries and will not be insured by the Federal Deposit Insurance Corporation or any other governmental agency or instrumentality.

Investing in the depositary shares involves a high degree of risk. Before buying any shares, you should read the discussion of risks of investing in our depositary shares in “ Risk Factors” beginning on page S-12of this prospectus supplement. None of the Securities and Exchange Commission, any state securities commission, the Federal Deposit Insurance Corporation (“FDIC”), the Board of Governors of the Federal Reserve System or any other regulatory body has approved or disapproved these securities or determined that this prospectus supplement or the accompanying prospectus is truthful or complete. Any representation to the contrary is a