Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 189

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 189
---
 Net loss                                               |     | $                       | (72,807 | ) |     | $ | (114,331 | ) |     | $ |  41,524 |   |

Comparison of the Years Ended December 31, 2024 and 2023 Net Revenue The following table summarizes net revenue by product for the years ended December 31, 2024 and 2023 (in thousands):

|                   |     | Year Ended December 31, |   2024 |     |   |   2023 |     |   |   Increase 
 (Decrease) |
|:------------------|:----|:------------------------|-------:|:----|:--|-------:|:----|:--|-----------:|
| ZTlido            |     |                         |        |     |   |        |     |   |            |
| Net Revenue       |     | $                       | 52,094 |     | $ | 46,300 |     | $ |      5,794 |
| ELYXYB            |     |                         |        |     |   |        |     |   |            |
| Net Revenue       |     |                         |  4,258 |     |   |    443 |     |   |      3,815 |
| GLOPERBA          |     |                         |        |     |   |        |     |   |            |
| Net Revenue       |     |                         |    238 |     |   |      — |     |   |        238 |
| Total Net Revenue |     | $                       | 56,590 |     | $ | 46,743 |     | $ |      9,847 |

Net revenue for the years ended December 31, 2024 and 2023 was $56.6 million and $46.7 million, respectively. The increase of $9.9 million was comprised of $5.8 million, $3.8 million and $0.2 million increase in net product sales of ZTlido, ELYXYB and GLOPERBA, respectively, with GLOPERBA sales commencing in June 2024. The increase in net sales of ZTlido and ELYXYB was driven by an increase in gross sales by 118

approximately 6% and 49%, respectively, as a result of an increase in the sales volume due to higher demand and a standard industry annual