Company: TVRD
Filing Date: 2025-02-14
Form Type: S-4/A
Source: 0001104659-25-013053
Chunk: 0

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-02-14
Form: S-4/A
Chunk 0
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TABLE OF CONTENTS

As filed with the Securities and Exchange Commission on February 13, 2025 Registration No. 333-283900 UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549 AMENDMENT NO. 2 TO FORM S-4 REGISTRATION STATEMENT
Under
The Securities Act of 1933 CARA THERAPEUTICS, INC.
(Exact name of Registrant as specified in its charter)

| ​ | Delaware                                                       
 (State or Other Jurisdiction ofIncorporation or Organization)​ | ​ | ​ | 2834                                                     
 (Primary Standard IndustrialClassification Code Number)​ | ​ | ​ | 75-3175693                             
 (I.R.S. EmployerIdentification Number) | ​ |

400 Atlantic Street
Suite 500
Stamford, CT 06901
(203) 406-3700 (Address, including zip code, and telephone number, including area code, of Registrant’s principal executive offices) Christopher Posner
Chief Executive Officer
Cara Therapeutics, Inc.
400 Atlantic Street
Suite 500
Stamford, CT 06901
(203) 406-3700 (Name, address, including zip code, and telephone number, including area code, of agent for service) Please send copies of all communications to:

| ​ | Daniel A. BagliebterJeffrey P. SchultzKenneth R. KochMintz Levin Cohn FerrisGlovsky and Popeo, P.C.919 Third AvenueNew York, NY 10022(212) 935-3000 | ​ | ​ | Scott TerrillionGeneral CounselCara Therapeutics, Inc.400 Atlantic StreetSuite 500Stamford, CT 06901(203) 406-3700 | ​ | ​ | Divakar GuptaCarlos RamirezRama PadmanabhanAnitha AnneCooley LLP55 Hudson YardsNew York, NY 10001(212) 479-6000 | ​ |

Approximate date of commencement of proposed sale to the public: As soon as practicable after the effectiveness of this registration statement and the satisfaction or waiver of all other conditions under the Merger Agreement described herein. If the securities being registered on this Form are being offered in connection with the formation of a holding company and there is compliance with General Instruction G, please check the following box. ☐ If this Form is filed to register additional securities for an offering pursuant to