Company: PSTV
Filing Date: 2025-06-18
Form Type: S-1
Source: 0001193125-25-142215
Chunk: 23

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-06-18
Form: S-1
Chunk 23
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,272 shares of common stock issuable upon exercise of stock options outstanding under our equity incentive 
 plans, with a weighted-average exercise price of $3.79 per share;                                               |

| • |     | 7,668 shares of common stock reserved for future issuance under our 2015 New Employee Incentive Plan; |

| • |     | 1,219,497 shares of common stock reserved for future issuance under our 2020 Stock Incentive Plan; |

| • |     | 398 and 27,792 shares of common stock issuable upon conversion of 1,014 shares of Series B Convertible Preferred 
 Stock and 938 shares of Series C Preferred Stock, respectively; and                                              |

| • |     | 19,396,099 shares of common stock issuable upon exercise of pre-funded or zero strike price warrants to purchase 
 common stock; and                                                                                                |

| • |     | 115,310,549 shares of common stock warrants that can be exercised into 454,415,621 shares of common stock, with a 
 range of exercise prices of $1.32 to $1.98 per share.                                                             |

14

THE SELLING STOCKHOLDER This prospectus relates to the possible resale by the selling stockholder, Lincoln Park, of shares of our common stock that have been and may be issued to Lincoln Park pursuant to the Purchase Agreement. We are filing the registration statement that includes this prospectus pursuant to the provisions of the Registration Rights Agreement, which we entered into with Lincoln Park on June 17, 2025, concurrently with our execution of the Purchase Agreement, in which we agreed to provide certain registration rights with respect to sales by Lincoln Park of the shares of our common stock that have been and may be issued to Lincoln Park under the Purchase Agreement. Lincoln Park, as the selling stockholder, may, from time to time, offer and sell pursuant to this prospectus up to 17,000,000 shares of our common stock that we may have issued or may sell to Lincoln Park under the Purchase Agreement. The selling stockholder may sell some, all, or none of its shares of common stock. We do not know how long the selling stockholder will hold the shares of our common stock before selling them, and we currently have no agreements, arrangements or understandings with the selling stockholder regarding the sale of any of the shares of common stock. See “Plan of Distribution”. The table below sets forth, to our knowledge, information concerning the beneficial ownership of