Company: TEM
Filing Date: 2025-02-25
Form Type: S-1
Source: 0001193125-25-034442
Chunk: 3

Company: Tempus AI, Inc.
Filing Date: 2025-02-25
Form: S-1
Chunk 3
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| MANAGEMENT                                                                 |     |   7 |
| EXECUTIVE COMPENSATION                                                     |     |  16 |
| CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS                       |     |  30 |
| PRINCIPAL STOCKHOLDERS                                                     |     |  34 |
| SELLING STOCKHOLDER                                                        |     |  37 |
| CERTAIN MATERIAL U.S. FEDERAL INCOME TAX CONSEQUENCES FOR NON-U.S. HOLDERS |     |  39 |
| PLAN OF DISTRIBUTION                                                       |     |  43 |
| LEGAL MATTERS                                                              |     |  45 |
| EXPERTS                                                                    |     |  45 |
| WHERE YOU CAN FIND MORE INFORMATION                                        |     |  46 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE                          |     |  47 |

You should rely only on the information contained in this prospectus. No one has been authorized to provide you with information that is different from that contained in this prospectus. This prospectus is dated as of the date set forth on the cover hereof. You should not assume that the information contained in this prospectus is accurate as of any date other than that date. i

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement on Form S-1 that we filed with the
Securities and Exchange Commission, or the SEC, using the “shelf” registration process. Under this shelf registration process, the selling stockholder may, from time to time (after the expiration of any applicable lock-up period described herein), sell the Shares offered by them described in this prospectus. We will not receive any proceeds from the sale by the selling stockholder of the Shares offered by them described in
this prospectus. We are registering the resale of the Shares as required by the Purchase Agreement.

Neither we nor the
selling stockholder have authorized anyone to provide you with any information or to make any representations other than those contained or incorporated by reference in this prospectus or any applicable prospectus supplement or any free writing
prospectuses prepared by or on behalf of us or to which we have referred you. Neither we nor the selling stockholder take responsibility for, or provide any assurance as to the reliability of, any other information that others may give you. Neither
we nor the selling stockholder will make an offer to sell these securities in any jurisdiction where the offer or sale is not permitted.

We may also provide a prospect