Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063906
Chunk: 334

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 334
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PCR technology. In this study, published in a peer -reviewedpublication and reported at several scientific meetings (below), DiamiR has demonstrated that the 24 miRNA biomarker candidates comprising CogniMIR ®panel, as well as additional miRNAs showing promise as RTT biomarker candidates, can be reliably and consistently detected in human plasma 199 samples with the methods implemented at DiamiR CLIA laboratory. While stem -loop -basedTaqMan and locked nucleic acid (LNA) -basedqPCR assays are shown to produce highly consistent results, Qiagen’s LNA -basedqPCR technology is better suited for a CAP/CLIA -certifiedclinical laboratory. (Diagnostics, 2023, 13:2170; Rett Syndrome Foundation Research Trust Conference, 2023, Boston MA, poster presentation; Alzheimer’s Association International Conference 2023, Amsterdam, Netherlands, poster presentation). Publications and Presentations During the last 12 years DiamiR has published a number of peer -reviewedpapers describing its technology for identification of miRNA biomarker pairs (the contents of these publications are not part of, and are not incorporated by reference into, this proxy statement/prospectus): 1.Analytical Validation of a Novel MicroRNA Panel for Risk Stratification of Cognitive Impairment. Arzu Kunwar, Kenny Kwabena Ablordeppey, Alidad Mireskandari, Kira Sheinerman, Michael Kiefer, Samuil Umansky and Gyanendra Kumar. Diagnostics 2023,13, 2170. https: // doi.org / 10.3390 / diagnostics13132170 2.Evaluation of long -termCOVID -19. Michael C. Kiefer and Samuil R. Umansky. Aging (Albany NY), 13(12): 15691 – 15693 (2021) 3.Brain -enrichedmicroRNAs circulating in plasma as novel biomarkers for Rett syndrome .Kira Sheinerman, Aleksandra Djukic, Vladimir G. Tsivinsky, and Samuil R. Umansky. PLOS ONE 14(7): e0218623 (2019) 4.Aging and aging -associateddiseases: a microRNA -basedendocrine regulation hypothesis .Samuil Umansky. Aging, Theory, 10(10): 2557 -2569(2018)