Company: PAYX
Filing Date: 2025-04-09
Form Type: 424B2
Source: 0001193125-25-076822
Chunk: 81

Company: PAYCHEX INC
Filing Date: 2025-04-09
Form: 424B2
Chunk 81
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 Report on Form 10-K for the
fiscal year ended May 31, 2024 from our definitive proxy statement on Schedule 14A, filed with the SEC on
August 30, 2024, for our 2024 annual meeting of stockholders;

3. Our Quarterly Reports on Form
10-Q for the quarter ended August31, 2024, filed with the SEC
October 1, 2024, for the quarter ended November30, 2024, filed with the SEC December 19,
2024 and for the quarter ended February 28, 2025, filed with the SEC March 26, 2025; and

4. Our Current Reports on Form 8-K filed with the SEC on June17, 2024, October11, 2024, January7, 2025 and February27, 2025.

You may obtain a copy of any or all of the documents referred to above which may have been or may be incorporated by reference into this
prospectus, except for exhibits to those documents (unless the exhibits are specifically incorporated by reference into those documents) at no cost to you by writing to us at the following address:

Paychex, Inc.

911 Panorama Trail
South

Rochester, New York 14625-2396

Attn: Corporate Secretary

Telephone: (585) 385-6666

19

$4,200,000,000 PAYCHEX, INC. $1,500,000,000 5.100% Notes due 2030 $1,500,000,000 5.350% Notes due 2032 $1,200,000,000 5.600% Notes due 2035 Prospectus Supplement Joint Book-Running Managers

| J.P. Morgan             |     | BofA Securities        |
| PNC Capital Markets LLC |     | Wells Fargo Securities |

Co-Managers

| BMO Capital Markets     |     | Truist Securities |     | Fifth Third Securities |
| KeyBanc Capital Markets |     | Mizuho            |     | M&T Securities         |
|                         |     | TD Securities     |     |                        |

April 8, 2025