Company: SHPH
Filing Date: 2025-02-27
Form Type: 424B3
Source: 0001493152-25-008478
Chunk: 150

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-02-27
Form: 424B3
Chunk 150
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,000 of RSUs and two of whom were granted $100,000 of RSUs. The RSUs vest over a two-year period in one third increments, with one-third vesting immediately upon signing and one-third vesting on each of the first and second anniversary of election. On December 23, 2024, each of the Directors were granted $150,000 of RSUs that vest over the next three calendar years. In addition, non-employee directors will also be reimbursed for out-of-pocket costs incurred in connection with attending meetings.

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Item 12. Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters

<div align='center'>PRINCIPAL STOCKHOLDERS</div>

The following table sets forth, as of the date of this Annual Report, the beneficial ownership of our common stock by each director and executive officer, by each person known by us to beneficially own 5% or more of our common stock and by directors and executive officers as a group. Unless otherwise stated, the address of the persons set forth in the table is c/o Shuttle Pharmaceuticals Holdings, Inc., 401 Professional Drive, Suite 260, Gaithersburg, MD 20879.

Beneficial ownership is determined in accordance with SEC rules and generally includes voting or investment power with respect to securities. Unless otherwise indicated, the stockholders listed in the table below have sole voting and investment power with respect to the shares indicated.

All share ownership figures include shares of our commons stock issuable upon securities convertible or exchangeable into shares of our common stock, whether or not convertible or exchangeable within 60 days of the effective date of this Annual Report. Such shares are deemed outstanding and beneficially owned by such person only for purposes of computing his or her percentage ownership, but not for purposes of computing the percentage ownership for any other person.

As of February 24, 2025, there were issued and outstanding 4,076,567 shares of common stock.

| Names and addresses                                 |     | Number of shares of common stock beneficially owned (#) |         |     | Percentage of shares of common stock beneficially owned (%) |       |   |
| Directors and Named Executive Officers:             |     |                                                         |         |     |                                                             |       |   |
| Anatoly Dritschilo, M.D.(1)                         |     |                                                         | 639,083 |     |                                                             |  15.7 | % |
| Timothy Lorber(2)