Company: HCWB
Filing Date: 2025-08-18
Form Type: 10-Q
Source: 0000950170-25-109642
Chunk: 2

Company: HCW Biologics Inc.
Filing Date: 2025-08-18
Form: 10-Q
Item: Item 2
Chunk 2
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 with Senescence-Associated Phenotype (“SASP”) proinflammatory factors has been implicated as a major source of chronic sterile inflammation leading to many aging-related pathologies.  SASP factors, including proinflammatory cytokines, chemokines, and proteinases, drive an inflammation cycle.  Senescence is considered a stress response and can be induced by a wide range of intrinsic and extrinsic insults.  Over time, these insults cause normal tissue cells to enter a senescent state of irreversible growth arrest accompanied by the release of SASP factors. The inflammation cycle promoted by SASP factors also activates immune cells.  Similar to senescent cells, prolonged activation of immune cells promotes the release of highly proinflammatory cytokines. Unresolved activation of immune cells leads to chronic low-grade inflammation, which perpetuates this cycle.