Company: SHPH
Filing Date: 2025-01-15
Form Type: S-1
Source: 0001493152-25-002253
Chunk: 80

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-01-15
Form: S-1
Chunk 80
---
 estimated that the number of cancer patients needing radiation therapy will increase by 22% in the next 10 years. ( See “The Future of Radiation Oncology in the United States From 2010 to 2020: Will Supply Keep Pace With Demand?” Benjamin D. Smith, Bruce G. Haffty, Lynn D. Wilson, Grace L. Smith, Akshar N. Patel, and Thomas A. Buchholz Journal of Clinical Oncology 2010 28:35, 5160-5165).

The American Society of Clinical Oncology (ASCO) estimates more than 80% of cancers in the U.S. occur in people in the age group of 50 and above with over 60% of cancers occurring in those 65 and over. ( See, 2018 Clinical Cancer Advances Report, American College of Clinical Oncology, 2018). For example, according to the American Cancer Society (ACS), more than 90% of colorectal cancer patients are individuals aged 50 years and older, with approximately 40% of all cases occurring in patients aged 75 years and over. The Colon Cancer Alliance estimates that 90% of new cases and 95% of deaths from colorectal cancers occur in people aged 50 or older. Also, the U.S. Census estimates that the age group of 65-84 will grow by 23% within the next five years, indicating a likely increase in the overall number of cancer patients in the U.S.

| 55 |

The table below details the number of cancers estimated in the United States in 2024:

<div align='center'>Estimated New Cancer Cases in the U.S.</div>

| Male                  |     |         |     |    |   |     | Female                |     |         |     |    |   |
| Prostate              |     | 299,010 |     | 27 | % |     | Breast                |     | 310,720 |     | 31 | % |
| Lung & bronchus       |     | 116,310 |     | 12 | % |     | Lung & bronchus       |     | 118,270 |     | 13 | % |
| Colon & rectum        |     |  81,540 |     |  8 | % |     | Colon & rectum        |     |  71,270 |     |  8 | % |
| Urinary bladder       |     |