Company: PSTV
Filing Date: 2025-08-12
Form Type: S-1
Source: 0001193125-25-178940
Chunk: 50

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-08-12
Form: S-1
Chunk 50
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 Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to 
 be the initial bona fide offering thereof.                                                                                                                                                                                                               |

| (6) | Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to                                                                                                                                                  
 directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public   
 policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer 
 or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the  
 opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be       
 governed by the final adjudication of such issue.                                                                                                                                                                                                        |

II-5

EXHIBIT INDEX

|         |     |                                                                                                            |     | Incorporated by Reference |      |     |             |           |     |         |      |     |             |            |
| Exhibit 
 Number  |     | Description                                                                                                |     | Form                      |      |     | File Number |           |     | Exhibit |      |     | Filing Date |            |
| 3.1     |     | Composite Certificate of Incorporation.                                                                    |     |                           | 10-K |     |             | 001-34375 |     |         |  3.1 |     |             | 03/11/2016 |
| 3.2     |     | Certificate of Amendment to Amended and Restated Certificate.                                              |     |                           | 8-K  |     |             | 001-34375 |     |         |  3.1 |     |             | 05/10/2016 |
| 3.3     |     | Certificate of Amendment to Amended and Restated Certificate.                                              |     |                           |