Company: PFSA
Filing Date: 2025-05-09
Form Type: S-4/A
Source: 0001213900-25-041151
Chunk: 301

Company: Profusa, Inc.
Filing Date: 2025-05-09
Form: S-4/A
Chunk 301
---
Profusa’s forecasts and key performance indicators are based on a number of assumptions, internal and third -partyestimates in published literature, and other business data, including assumptions and estimates relating to Profusa’s ability to manage operating expenses of, invest in, develop and generate revenue from Profusa’s in vivo sensing platforms and related services in the future. 17While Profusa believes its assumptions and the data underlying Profusa’s estimates and key performance indicators are reasonable, there are inherent challenges in measuring or forecasting such information. As a result, these assumptions and estimates may not be correct and the conditions supporting Profusa’s assumptions or estimates may change at any time, thereby reducing the predictive accuracy of these underlying factors and metrics. Consequently, Profusa’s estimates of the total addressable markets and Profusa’s forecasts of market growth for Profusa’s novel in vivo sensing platform and differentiated product candidates may prove to be incorrect. For example, if the annual total addressable markets or the potential market growth for Profusa’s Lumee Oxygen product is smaller than Profusa has estimated or if the key business metrics Profusa utilized to forecast commercial opportunities are inaccurate, it may have an adverse effect on Profusa’s business, financial condition, results of operations and prospects. ____________ 10https://journals.viamedica.pl/clinical_diabetology/article/view/61700 11https://www.health.com/condition/type -2-diabetes/12 -myths-about-insulin-and-type-2-diabetes 12https://accisstoolkit.haiweb.org/wp -content/uploads/2020/10/Estimate -of-Insulin-Use-in-Type-2-Diabetes1.pdf 13https://www.liebertpub.com/doi/epdf/10.1089/dia.2021.0271 14https://www.census.gov/topics/population.html — This source shows the massive health and wellness market which does not require reimbursement 15https://ec.europa.eu/urostat/web/population -demography/population -housing-censuses/database — only population 18 and over was considered 16https://www.cdc.gov/diabetes/basics/prediabetes.html#:~:text=What%20Is%20Prediabetes%3F,t%20know%20they
%20have%20it. 17https://www.cdc.gov/diabetes/basics/prediabetes.html#:~:text=What%20Is%20Prediabetes