Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 388

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 388
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 the registration statement of which this prospectus forms a part.

Legal Fee Assumption Letter Agreement

In connection with the Legal Fee Assumption in accordance with the Sorrento SPA, we and Sorrento entered into a letter agreement on
September 21, 2023, pursuant to which, among other things, we agreed to

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assume all of Sorrento’s obligations for certain legal fees and expenses in the aggregate amount of approximately $12.25 million.

Subsidiary Guarantee

On
September 21, 2023, in connection with the Scilex-Oramed SPA, we and each of our subsidiaries (collectively, the “Guarantors”) entered into a subsidiary guarantee (the “Subsidiary Guarantee”) with Oramed (together with its
successors and permitted assigns, the “Holder”) and the Agent, as the collateral agent for the holder of the Oramed Note, pursuant to which, the Guarantors have agreed to guarantee and act as surety for payment of the Oramed Note and any
additional notes issued by us after the closing date of the transactions contemplated by the Scilex-Oramed SPA in full or partial substitution of the Oramed Note (the “Additional Notes”).

In connection with the refinancing disclosed above under “Tranche B Securities Purchase Agreement”, our Company, the
Guarantors, Oramed and the Agent agreed to amend the Subsidiary Guarantee by entering into the Subsidiary Guarantee Amendment (the “Subsidiary Guarantee Amendment”), dated October 8, 2024, to reflect the refinancing arrangement as set
out below.

The foregoing summaries of the Subsidiary Guarantee and the Subsidiary Guarantee Amendment do not purport to be complete and
are qualified in their entirety by reference to the full text of the Subsidiary Guarantee and the Subsidiary Guarantee Amendment, a copy of each of which is filed as an exhibit to our Current Report on
Form 8-K filed on September 26, 2023 and October 8, 2024, respectively.

Amended and Restated Security Agreement

On September 21, 2023, we and the Guarantors entered into a security agreement (the
“Security Agreement”) with the Holder and the Agent, pursuant to which we and the Guarantors granted to the Agent (on behalf of and for the benefit of the holder of the Oramed Note and