Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 190

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 190
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| GLOPERBA          |     |                         |        |     |   |        |     |   |            |
| Net Revenue       |     |                         |    238 |     |   |      — |     |   |        238 |
| Total Net Revenue |     | $                       | 56,590 |     | $ | 46,743 |     | $ |      9,847 |

Net revenue for the years ended December 31, 2024 and 2023 was $56.6 million and $46.7 million, respectively. The increase of $9.9 million was comprised of $5.8 million, $3.8 million and $0.2 million increase in net product sales of ZTlido, ELYXYB and GLOPERBA, respectively, with GLOPERBA sales commencing in June 2024. The increase in net sales of ZTlido and ELYXYB was driven by an increase in gross sales by 119

approximately 6% and 49%, respectively, as a result of an increase in the sales volume due to higher demand and a standard industry annual price increase, partially offset by an increase in rebates. The commercial launch of ELYXYB has been met with a strong response from the prescribing community since its commercial launch in April 2023 and continued to show growth during 2024, the first full year of commercialization. Cost of Revenue The following table summarizes cost of revenue by product for the years ended December 31, 2024 and 2023 (in thousands):

|                             |     |   | Year Ended December 31, 
                    2024 |     |   |   2023 |     |   |   Increase 
 (Decrease) |   |
|:----------------------------|:----|:--|------------------------:|:----|:--|-------:|:----|:--|-----------:|:--|
| ZTlido                      |     |   |                         |     |   |        |     |   |            |   |
| Cost of Revenue             |     | $ |                   6,249 |     | $ |  6,631 |     | $ |       (382 | ) |
| Cost of Revenue - Royalties |     |   |                   9,854 |     |   |  8,544 |     |   |      1,310 |   |
| Other