Company: PFSA
Filing Date: 2025-08-29
Form Type: S-1
Source: 0001213900-25-082672
Chunk: 391

Company: Profusa, Inc.
Filing Date: 2025-08-29
Form: S-1
Chunk 391
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 or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the shares of common stock being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. II-6

SIGNATURES Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this prospectus to be signed on its behalf by the undersigned, thereunto duly authorized.

| PROFUSA, INC.         
 Date: August 29, 2025 |     | By:    |     | /s/ Ben Hwang                               |
|:----------------------|:----|:-------|:----|:--------------------------------------------|
|                       |     | Name:  |     | Ben Hwang                                   |
|                       |     | Title: |     | Chairman of the Board and Chief Executive   |
|                       |     |        |     | -Principal Executive Officer                |
| Date: August 29, 2025 |     | By:    |     | /s/ Fred Knechtel                           |
|                       |     | Name:  |     | Fred Knechtel                               |
|                       |     | Title: |     | Chief Financial Officer                     |
|                       |     |        |     | -Principal Financial and Accounting Officer |

POWER OF ATTORNEY KNOW ALL MEN BY THESE PRESENTS, that the undersigned officers and directors of Profusa, Inc., a Delaware corporation, that is filing a registration statement on Form S -1with the Securities and Exchange Commission under the provisions of the Securities Act of 1933, as amended, hereby constitute and appoint Ben Hwang and Fred Knechtel their true and lawful attorneys -in-factand agents, with full power of substitution and re -substitution, for him and in his name, place and stead, in any and all capacities, to sign any or all amendments (including post -effectiveamendments, exhibits thereto and other documents in connection therewith) to the registration statement, any subsequent registration statement filed by the registrant pursuant to Rule 462(b) of the Securities Act of 1933