Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 11

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 11
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 all the risks of an investment in the Notes. Prospective investors should consult their own financial and legal advisers about risks associated with investment in the Notes and the suitability of investing in the Notes in light of their particular circumstances.

This prospectus supplement and the accompanying prospectus also contain forward-looking statements that involve risks and uncertainties. Takeda’s actual results could differ materially from those anticipated in these forward-looking statements as a result of various factors, including the risks described below, elsewhere in this prospectus supplement and in “Item 3. Key Information—D. Risk Factors” of Takeda’s most recent annual report on Form 20-F, which is incorporated herein by reference.

#### Risks Relating to Our Business
For information on risks relating to our business, see “Item 3. Key Information—D. Risk Factors” in Takeda’s most recent annual report on Form 20-F and similar information in any other documents incorporated by reference herein.

#### Risks Relating to the Notes and the Guarantee
The Notes and Guarantee are unsecured obligations.

Because the Notes and the Guarantee are unsecured obligations, their repayment may be compromised if:

• TUSFI or TPC enter into bankruptcy, liquidation, rehabilitation or other winding-up proceedings;

• TUSFI or TPC default in payment under our secured indebtedness or other unsecured indebtedness; or

• any of the indebtedness of TUSFI or TPC is accelerated.

If any of these events occurs, the assets of Takeda may not be sufficient to pay amounts due on the Notes.

The Notes and the Guarantee will be structurally subordinated to indebtedness and other liabilities of TPC’s subsidiaries other than the Issuer.

The Notes are obligations of the Issuer and are guaranteed exclusively by the Guarantor. The subsidiaries of TPC other than the Issuer are separate and distinct legal entities and have no obligation to pay any amounts due on the Notes or the Guarantee or to provide the Issuer or Guarantor with funds for the payment obligations under the Notes or the Guarantee.

In addition, there is no restriction under the TUSFI Indenture on the amount of debt or preferred equity that TPC’s subsidiaries may incur or issue. To the extent such debt or preferred equity of TPC’s subsidiaries other than the Issuer is incurred or issued to third parties, the claims of such third parties have priority as to the assets of such subsidiaries over the claims of TPC as a common equity holder of such subsidiaries. Consequently, in the event