Company: BFRG
Filing Date: 2025-11-07
Form Type: 424B5
Source: 0001493152-25-021283
Chunk: 0

Company: BullFrog AI Holdings, Inc.
Filing Date: 2025-11-07
Form: 424B5
Chunk 0
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Filed pursuant to Rule 424(b)(5)

Registration No. 333-281341

PROSPECTUS SUPPLEMENT

(To the Prospectus dated August 21, 2024 and Prospectus Supplement dated April 25, 2025)

<div align='center'>BullFrog AI Holdings, Inc.

Up to $2.0 million

Of Shares of Common Stock</div>

This prospectus supplement (this “Prospectus Supplement No. 2”) amends and supplements certain information in our prospectus, dated August 21, 2024 (the “Base Prospectus”) and the prospectus supplement, dated April 25, 2025 (the “Prospectus Supplement No. 1”, and together with the Base Prospectus, the “ATM Prospectus”), both filed with the U.S. Securities and Exchange Commission as part of our registration statement on Form S-3 (333-281341), relating to the offer and sale of shares of our common stock, $0.00001 par value per share, from time to time pursuant to the terms of the At-the-Market Sales Agreement, or the Sales Agreement, with BTIG, LLC, or the sales agent. This Prospectus Supplement No. 2 should be read in conjunction with the ATM Prospectus, and is qualified by reference thereto, except to the extent that the information herein amends or supersedes the information contained in the ATM Prospectus. This Prospectus Supplement No. 2 is not complete without, and may only be delivered or utilized in connection with, the ATM Prospectus, and any future amendments or supplements thereto.

Our common stock is listed on the Nasdaq Capital Market under the symbol “BFRG.” On November 6, 2025, the last reported sale price of our common stock was $0.96 per share. As of November 6, 2025, the aggregate market value of our outstanding common stock held by non-affiliates (the “Public Float”) was approximately $14.0 million based on 11,400,405 total shares of outstanding common stock, of which approximately 9.0 million shares were held by non-affiliates, and a price of $1.56 per share, which was the closing price of our common stock on the Nasdaq Capital Market on October 8, 2025, the highest closing sale price of our common stock on the Nasdaq Capital Market within 60 days prior to the date of this