Company: AGIO
Filing Date: 2025-04-25
Form Type: DEF 14A
Source: 0001193125-25-096719
Chunk: 12

Company: AGIOS PHARMACEUTICALS, INC.
Filing Date: 2025-04-25
Form: DEF 14A
Chunk 12
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 to serve on our board of directors as Class III directors, each for a three-year term; |

| • |     | FOR the approval, on an advisory (non-binding) basis, of the compensation of our named executive officers; |

| • |     | FOR the approval of an amendment to our 2023 Stock Incentive Plan to increase the number of shares of common stock available thereunder by 2,500,000 shares; and |

**Are there other matters to be voted on at the Annual Meeting? We do not know of any matters that may come before the Annual Meeting other than the election of our Class III directors, the approval, on an advisory basis, of the compensation of our named executive officers, the approval of an amendment to our 2023 Stock Incentive Plan and the ratification of the appointment of our independent registered public accounting firm. If any other matters are properly presented at the Annual Meeting, the persons named in the accompanying proxy intend to vote, or otherwise act, in accordance with their judgment on the matter. Who will count the votes? The votes will be counted, tabulated and certified by Mediant, a BetaNXT business. Will my vote be kept confidential? Your vote will be kept confidential and we will not disclose your vote, unless (1) we are required to do so by law (including in connection with the pursuit or defense of a legal or administrative action or proceeding), or (2) there is a contested election for the board of directors. The inspector of election will forward any written comments that you make on the proxy card to management without providing your name, unless you expressly request disclosure on the proxy card. How do I submit a question at the Annual Meeting? If you wish to submit a question, on the day of the Annual Meeting, beginning at 8:00 a.m., Eastern Time on Wednesday, June 18, 2025, you may log into the virtual meeting platform using the unique link provided to you via email following the completion of your registration at www.proxydocs.com/AGIO, and follow the instructions there. Our virtual meeting will be governed by our Rules of Conduct and Procedures, which will be posted at www.proxydocs.com/AGIOin advance of the meeting. The Rules of Conduct and Procedures will 7

govern the ability of stockholders to ask questions during the meeting, including rules on permissible topics, and rules for how questions and comments will be recognized and disclosed to meeting participants. All questions asked in accordance with the Rules of