Company: TYRA
Filing Date: 2025-05-08
Form Type: S-3
Source: 0001193125-25-116008
Chunk: 26

Company: Tyra Biosciences, Inc.
Filing Date: 2025-05-08
Form: S-3
Chunk 26
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 U.S. federal income tax purposes as a result of the deposit, defeasance and discharge and will be subject to U.S. federal income tax on the same amounts and in the same manner and at the same times as would have been the case if the deposit, defeasance and discharge had not occurred. (Section 8.3) Defeasance of Certain Covenants. The indenture provides that, unless otherwise provided by the terms of the applicable series of debt securities, upon compliance with certain conditions:

| • |     | we may omit to comply with the covenant described under the heading “Consolidation, Merger and Sale of                                                                  
 Assets” and certain other covenants set forth in the indenture, as well as any additional covenants which may be set forth in the applicable prospectus supplement; and |

| • |     | any omission to comply with those covenants will not constitute a Default or an Event of Default with respect to 
 the debt securities of that series (“covenant defeasance”).                                                      |

The conditions include:

| • |     | depositing with the trustee money and/or U.S. government obligations or, in the case of debt securities                                                                                                                                                   
 denominated in a single currency other than U.S. Dollars, government obligations of the government that issued or caused to be issued such currency, that, through the payment of interest and principal in accordance with their terms, will provide     
 money in an amount sufficient in the opinion of a nationally recognized firm of independent public accountants or investment bank to pay and discharge each installment of principal of, premium and interest on, and any mandatory sinking fund payments 
 in respect of, the debt securities of that series on the stated maturity of those payments in accordance with the terms of the indenture and those debt securities; and                                                                                   |

| • |     | delivering to the trustee an opinion of counsel to the effect that the holders of the debt securities of that                                                                                                                                       
 series will not recognize income, gain or loss for United States federal income tax purposes as a result of the deposit and related covenant defeasance and will be subject to United States federal income tax on the same amounts and in the same 
 manner and at the same times as would have been the case if the deposit and related covenant defeasance had not occurred. (Section 8.4)                                                                                                             |

No Personal Liability of Directors, Officers, Employees or Securityholders None of our past, present or future directors, officers, employees or securityholders, as such