Company: SHPH
Filing Date: 2025-11-18
Form Type: S-1
Source: 0001493152-25-024089
Chunk: 10

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-11-18
Form: S-1
Chunk 10
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the “June 2025 Purchase Agreement”), for the sale by the Company to the selling stockholder, in a private placement, of 21,924 shares of common stock of the Company and 1,158,953 pre-funded warrants, each to purchase one share of common stock of the Company at a purchase price of $3.599 and exercise price of $0.001 per pre-funded warrant (the “June 2025 Private Placement”). The June 2025 Private Placement closed on June 24, 2025 and we received gross proceeds of approximately $4.3 million before deducting fees and other offering expenses payable by us.

Other than the transactions described above and in “The Private Placement,” we have had no material relationships with the selling stockholder in the last three (3) years.

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<div align='center'>PLAN OF DISTRIBUTION</div>

The selling stockholder and any of its pledgees, assignees and successors-in-interest may, from time to time, sell any or all of its securities covered hereby on the Nasdaq Capital Market or any other stock exchange, market or trading facility on which the securities are traded or in private transactions. These sales may be at fixed or negotiated prices. The selling stockholder may use any one or more of the following methods when selling securities:

| ● | ordinary                                                                                                                          
 brokerage transactions and transactions in which the broker-dealer solicits purchasers;                                           |
| ● | block                                                                                                                             
 trades in which the broker-dealer will attempt to sell the securities as agent but may position and resell a portion of the block 
 as principal to facilitate the transaction;                                                                                       |
| ● | purchases                                                                                                                         
 by a broker-dealer as principal and resale by the broker-dealer for its account;                                                  |
| ● | an                                                                                                                                
 exchange distribution in accordance with the rules of the applicable exchange;                                                    |
| ● | privately                                                                                                                         
 negotiated transactions;                                                                                                          |

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| ● | settlement                                                                                                                                
 of short sales;                                                                                                                           |
| ● | in                                                                                                                                        
 transactions through broker-dealers that agree with the selling stockholder to sell a specified number of such securities at a stipulated 
 price per security;                                                                                                                       |
| ● | through                                                                                                                                   
 the writing or settlement of options or other hedging transactions, whether through an options exchange or otherwise;                     |
| ● | a                                                                                                                                         
 combination of any such methods of sale; or                                                                                               |
| ● | any                                                                                                                                       
 other method permitted pursuant to applicable law.