Company: SCLXW
Filing Date: 2025-08-04
Form Type: S-1
Source: 0001193125-25-172703
Chunk: 8

Company: Scilex Holding Co
Filing Date: 2025-08-04
Form: S-1
Chunk 8
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 |     | our ability to execute our business plans and strategy; |

| • |     | our ability to prevent, respond to, and recover from a cybersecurity incident; |

| • |     | the effect of any geopolitical conflicts or new or increased international tariffs, including mitigation efforts and economic effects, on any of the foregoing or other aspects of our business operations, including but not limited to our clinical studies and clinical trials; |

| • |     | the effect of global economic and political developments, including the conflicts in Ukraine and Israel; and |

| • |     | other factors detailed under the section of this prospectus titled “Risk Factors.” |

Should one or more of these risks or uncertainties materialize or should any of the assumptions made by our management prove incorrect, actual results may vary in material respects from those projected in these forward-looking statements. There may be additional risks that we consider immaterial or which are unknown. It is not possible to predict or identify all such risks. We do not undertake any obligation to update, add or to otherwise correct any forward-looking statements contained herein to reflect events or circumstances after the date they were made, whether as a result of new information, future events, inaccuracies that become apparent after the date hereof or otherwise, except as may be required under applicable securities laws. 3

CERTAIN DEFINED TERMS

| • |     | “April 2024 RDO Common Warrants” means the warrants to purchase up to an aggregate of 428,572 shares of our Common Stock at an exercise price of $38.50 per share, issued to the investor named in and pursuant to the April 2024 RDO Purchase Agreement. |

| • |     | “April 2024 RDO Placement Agent Warrants” means the warrants to purchase up to an aggregate of 34,286 shares of our Common Stock at an exercise price of $43.75 per share, issued to the Placement Agents pursuant to the April 2024 RDO Purchase Agreement. |

| • |     | “April 2024 RDO Warrants” means the April 2024 RDO Common Warrants and the April 2024 RDO Placement Agent Warrants. |

| • |     | “B. Riley” means B. Riley Principal Capital II, LLC. |

| • |     | “Board” means the board of directors of the Company. |

| • |     | “Business Combination” means the merger contemplated by the Merger Agreement. |

| • |     | “Closing