Company: CRNX
Filing Date: 2025-05-20
Form Type: DEFA14A
Source: 0000950170-25-074707
Chunk: 0

Company: Crinetics Pharmaceuticals, Inc.
Filing Date: 2025-05-20
Form: DEFA14A
Chunk 0
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

| Filed by the Registrant   | Filed by a Party other than the Registrant   |

Check the appropriate box:

|  |     | Preliminary Proxy Statement                                                     |
|  |     | Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) |
|  |     | Definitive Proxy Statement                                                      |
|  |     | Definitive Additional Materials                                                 |
|  |     | Soliciting Material under §240.14a-12                                           |

Crinetics Pharmaceuticals, Inc. (Name of Registrant as Specified In Its Charter) (Name of Person(s) Filing Proxy Statement, if other than the Registrant) Payment of Filing Fee (Check all boxes that apply):

|  |     | No fee required                                                                                     |
|  |     | Fee paid previously with preliminary materials                                                      |
|  |     | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11 |

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6055 Lusk Boulevard

San Diego, CA 92121

SUPPLEMENT TO PROXY STATEMENT
FOR THE 2025 ANNUAL MEETING OF STOCKHOLDERS
TO BE HELD ON WEDNESDAY, JUNE 11, 2025</div>

On April 23, 2025, Crinetics Pharmaceuticals, Inc. (the “Company”) filed with the Securities and Exchange Commission (the “SEC”) and made available to stockholders its definitive proxy statement (the “Proxy Statement”) relating to the Company’s 2025 Annual Meeting of Stockholders (the “Annual Meeting”), to be held on June 11, 2025, at 8:00 a.m. Pacific Time.

The Company is filing this supplement to the Proxy Statement (this “Supplement”) in order to correct certain inadvertent clerical errors contained in the Proxy Statement, as set forth below:

The Proxy Statement correctly identified the Annual Meeting date as June 11, 2025; however, the day of the week was incorrectly stated on pages 1 and 2 of the Proxy