Company: NCNA
Filing Date: 2025-06-18
Form Type: F-3/A
Source: 0001193125-25-142565
Chunk: 42

Company: NuCana plc
Filing Date: 2025-06-18
Form: F-3/A
Chunk 42
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 construed in accordance with the laws of the State of New York, except to the extent that the Trust Indenture Act is applicable.

Subordination of Subordinated Debt Securities

Our obligations pursuant to any subordinated debt securities will be unsecured and will be subordinate and junior in priority of payment to
certain of our other indebtedness to the extent described in a prospectus supplement. The subordinated indenture does not limit the amount of senior indebtedness we may incur. It also does not limit us from issuing any other secured or unsecured
debt.

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DESCRIPTION OF WARRANTS General We may issue warrants to purchase our ordinary shares represented by ADSs and/or debt securities in one or more series together with other securities or separately, as described in the applicable prospectus supplement. Below is a description of certain general terms and provisions of the warrants that we may offer. Particular terms of the warrants will be described in the warrant agreements and the prospectus supplement relating to the warrants. The applicable prospectus supplement will contain, where applicable, the following terms of and other information relating to the warrants:

| • |     | the specific designation and aggregate number of, and the price at which we will issue, the warrants; |

| • |     | the currency or currency units in which the offering price, if any, and the exercise price payable; |

| • |     | the designation, amount and terms of the securities purchasable upon exercise of the warrants; |

| • |     | if applicable, the exercise price for our ADSs and the number of ADSs to be received upon exercise; |

| • |     | if applicable, the exercise price for our debt securities, the amount of debt securities to be received upon 
 exercise, and a description of that series of debt securities;                                               |

| • |     | the date on which the right to exercise the warrants will begin and the date on which that right will expire or,                             
 if you may not continuously exercise the warrants throughout that period, the specific date or dates on which you may exercise the warrants; |

| • |     | whether the warrants will be issued in fully registered form or bearer form, in definitive or global form or in                                                                    
 any combination of these forms, although, in any case, the form of a warrant included in a unit will correspond to the form of the unit and of any security included in that unit; |

| • |     | any applicable material U.S. federal income tax consequences and any applicable material U.K. tax consequences