Company: SCLXW
Filing Date: 2025-07-23
Form Type: 424B3
Source: 0001193125-25-163077
Chunk: 177

Company: Scilex Holding Co
Filing Date: 2025-07-23
Form: 424B3
Chunk 177
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| operations@3ifund.com      |     |                             |

[ Signature Page to Exchange Agreement]

IN WITNESS WHEREOF, each of the undersigned have caused their respective signature page to this Agreement to be duly executed as of the date first written above.

| SCILEX HOLDING COMPANY                       |     |                 |
| By:                                          |     | /s/ Jaisim Shah |
| Name: Jaisim Shah                            |     |                 |
| Title: Chief Executive Officer and President |     |                 |

[ Signature Page to Exchange Agreement]

Annex A

Form of New Tranche B Warrant

Exhibit 10.6

[FORM OF WARRANT]

THE NUMBER OF SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE OF THIS WARRANT MAY BE LESS THAN THE AMOUNTS SET FORTH ON THE FACE HEREOF PURSUANT TO SECTION 1(a) OF THIS WARRANT.

S CILEXH OLDINGC OMPANY

W ARRANTT OP URCHASEC OMMONS TOCK

Warrant No.:

Date of Issuance:
October 8, 2024 (“Issuance Date”)

Date of Exchange: _________ 2025 (“Exchange Date”)

Scilex Holding Company, a Delaware corporation (the “Company”), hereby certifies that, for good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, [BUYER], the registered holder hereof or its permitted assigns (the “Holder”), is entitled, subject to the terms set forth below, to purchase from the
Company, at the Exercise Price (as defined below) then in effect, upon exercise of this Warrant to Purchase Common Stock (including any Warrants to Purchase Common Stock issued in exchange, transfer or replacement hereof, the
“Warrant”), at any time or times on or after the Issuance Date, but not after 11:59 p.m., New York time, on the Expiration Date (as defined below), _________________ (subject to adjustment as provided herein) fully paid and non-assessable shares of Common Stock (as defined below)(the “Warrant Shares”, and such number of Warrant Shares, the “Warrant Number”). Except as otherwise defined herein,
capitalized terms in this Warrant shall have the meanings set forth in Section 19. This Warrant is one of a series of Warrants to Purchase Common Stock (the “New Tranche B Warrants”) that has been issued pursuant