Company: PSTV
Filing Date: 2025-08-12
Form Type: S-1
Source: 0001193125-25-178940
Chunk: 53

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-08-12
Form: S-1
Chunk 53
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 |     | Form of Side Letter between Plus Therapeutics, Inc. and certain holders of warrants, dated as of June 17, 2025.              |     |                           | 8-K |     |             | 001-34375  |     |         |  10.1 |     |             | 06/17/2025 |
| 10.41   |     | Form of Support Letter, dated July 11, 2025, by and between Plus Therapeutics, Inc. and certain holders                      |     |                           |     |     |             |            |     |         |       |     |             |            |
| 23.1    |     | Consent of Independent Registered Public Accounting Firm.                                                                    |     |                           |     |     |             |            |     |         |       |     |             |            |
| 23.2    |     | Consent of Sullivan & Worcester LLP (included in Exhibit 5.1 hereto).                                                        |     |                           |     |     |             |            |     |         |       |     |             |            |
| 24.1    |     | Power of Attorney.                                                                                                           |     |                           |     |     |             |            |     |         |       |     |             |            |
| 107     |     | Filing Fee Table                                                                                                             |     |                           |     |     |             |            |     |         |       |     |             |            |

| 

# | Indicates management contract or compensatory plan or arrangement. |
| + | Portions of this exhibit have been redacted pursuant to Item 601(b)(10)(iv). |

II-9

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Houston, State of Texas, on August 12, 2025.

| PLUS THERAPEUTICS, INC. |     |                                       |
| By:                     |     | /s/ Marc H. Hedrick, MD               |
|                         |     | Marc H. Hedrick, MD                   |
|                         |     | President and Chief Executive Officer |

POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Marc H. Hedrick, MD and Andrew Sims, and each of them