Company: RGNX
Filing Date: 2025-03-13
Form Type: S-8
Source: 0000950170-25-038862
Chunk: 1

Company: REGENXBIO Inc.
Filing Date: 2025-03-13
Form: S-8
Chunk 1
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 the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.

<div align='center'>EXPLANATORY NOTE</div>

This Registration Statement on Form S-8 (the “Registration Statement”) is filed by REGENXBIO Inc. (the “Company”) for the purpose of registering additional shares of its common stock, par value $0.0001 per share (the “Common Stock”), under the Company’s 2015 Equity Incentive Plan (the “Incentive Plan”).

The number of shares of Common Stock available for issuance under the Incentive Plan is subject to an automatic annual increase as of the first business day of the Company’s fiscal year equal to the lower of (a) 4.0% of the total number of shares of Common Stock outstanding on December 31 of the prior year or (b) a number of shares of Common Stock determined by the Company’s Board of Directors (the “Incentive Plan Provision”). Accordingly, the number of shares of Common Stock available for issuance under the Incentive Plan was increased by 1,981,975 shares effective January 2, 2025. This Registration Statement registers the offer and sale of the 1,981,975 additional shares of Common Stock that are available for issuance under the Incentive Plan as a result of the Incentive Plan Provision.

Of the 17,928,064 shares of Common Stock currently authorized by the Incentive Plan, in addition to the shares, the offer and sale of which are being registered hereby, the Company has previously registered the offer and sale of: (a) 2,952,100 shares of Common Stock pursuant to the Company’sRegistration Statement on Form S-8 filed on September 17, 2015(Commission File No. 333-206984), (b) 1,052,538 shares of Common Stock pursuant to the Company’sRegistration Statement on Form S-8 filed on March 3, 2016(Commission File No. 333-209899), (c) 1,059,065 shares of Common Stock pursuant to the Company’sRegistration Statement on Form S-8 filed on March 7, 2017(Commission File No. 333-216508), (d) 1,251,810 shares of Common Stock pursuant to the Company’sRegistration Statement on Form S-