Company: DRTSW
Filing Date: 2025-03-12
Form Type: 20-F
Source: 0001213900-25-023187
Chunk: 149

Company: Alpha Tau Medical Ltd.
Filing Date: 2025-03-12
Form: 20-F
Item: Item 4
Chunk 149
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orption of the alpha-emitting
decay chain.

Our Applicators and Accessories

Our applicators

The Alpha DaRT applicator
is composed of a needle or tube (with an attached hub) with the Alpha DaRT sources placed inside for deployment into a tumor, and a stylet
(with an attached hub) which functions like a plunger in the needle or tube to eject the source(s) towards the appropriate location within
the tumor. A protective cap is attached to the needle to prevent inadvertent damage or loss of a source, and a safety screw is used to
fasten the needle and the stylet firmly together. Additionally, the sources are encapsulated with glycerin, a biocompatible material which
is designed to act as a sealant to trap the decay product Radon-220 gas from release until it is ejected into the tumor by the applicator.
Each applicator can hold multiple sources, often up to six in one applicator, for deployment in a single injection.

We have developed seven applicators
designed to cover a range of potential applications, including the treatment delivery method, the duration of the sources’ implantation,
and on the location of the tumor.

For the temporary implantation
of sources into superficial tumors, we have developed the following three categories of applicators:

  Alpha DaRT Needle Applicator                                                                                                         

  Alpha DaRT Flex Applicator                                                                                                             
  - designed for difficult geometry insertions. This applicator is in the form of a flexible (Kapton) tube, wherein the sources are      
  strung upon a biocompatible suture and loaded inside the tube. The Flex Applicator is designed to be used in conjunction with a rigid  
  hypodermic needle, which may be straight or curved, depending upon the specific geometry of the patient’s tumor and the physician’s    
  preference; and                                                                                                                        
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  Alpha DaRT Template Applicator                                                                                                            

All of the foregoing applicators
are designed to be supplied preloaded, sealed and ready for immediate use in the procedure room.

We have also developed a number
of applicators for implantation of sources into tumors inside the body:

  Alpha DaRT Plant Applicator                                                                                                            

  Alpha DaRT Scope Applicator                                                                                                               

  Loading Device - designed                                                                                                                      

  Radial Applicator - designed                                                                                                              

Below are images of several