Company: CMA
Filing Date: 2025-10-06
Form Type: 425
Source: 0001193125-25-230871
Chunk: 1

Company: COMERICA INC
Filing Date: 2025-10-06
Form: 425
Chunk 1
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 Securities Exchange Act of 1934 (17 CFR 240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

ITEM 8.01 OTHER EVENTS. On October 6, 2025, Comerica Incorporated and Fifth Third Bancorp issued a joint press release announcing the execution of a definitive merger agreement pursuant to which, on the terms and subject to the conditions set forth therein, (i) Comerica Incorporated will merge with Fifth Third Financial Corporation, a wholly owned subsidiary of Fifth Third Bancorp, with Fifth Third Financial Corporation as the surviving corporation in the merger and (ii) immediately thereafter, Comerica Holdings Incorporated will merge with and into Fifth Third Financial Corporation, with Fifth Third Financial Corporation as the surviving corporation in the merger. A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-Kand is incorporated herein by reference. ITEM 9.01 FINANCIAL STATEMENTS AND EXHIBITS. (d) Exhibits

| 99.1 |     | Joint Press Release of Comerica Incorporated and Fifth Third Bancorp, dated October 6, 
 2025.                                                                                  |
|:-----|:----|:---------------------------------------------------------------------------------------|
| 104  |     | Cover Page Interactive Data File (embedded within the Inline XBRL document)            |

FORWARD-LOOKING STATEMENTS This communication contains statements that constitute “forward-looking statements” within the meaning of, and subject to the protections of, Section 27A of the Securities Act, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as “achieve,” “anticipate,” “assume,” “believe,” “could,” “deliver,” “drive,” “enhance,” “estimate,” “expect,” “focus,” “future,” “goal,” “grow,” “guidance,” “intend,” “may,” “might,” “plan,” “position,” “potential,” “predict,” “project,” “opportunity,” “outlook,” “should,” “strategy,” “target,” “trajectory,” “trend,” “will