Company: BDRX
Filing Date: 2025-12-08
Form Type: F-1/A
Source: 0001214659-25-017719
Chunk: 140

Company: Biodexa Pharmaceuticals Plc
Filing Date: 2025-12-08
Form: F-1/A
Chunk 140
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 The failure to file IRS Form 8621 could result in the imposition of penalties and the extension of the
statute of limitations with respect to United States federal income tax.

The United States federal
income tax rules relating to PFICs are complex. U.S. Holders are urged to consult their tax advisors with respect to the purchase, ownership
and disposition of the Depositary Shares, the Pre-Funded Warrants, and the Series L Warrants, the availability of the mark-to-market election
and whether making the election would be advisable in their particular circumstances, and the IRS information reporting obligations with
respect to the purchase, ownership and disposition of the Depositary Shares, the Pre-Funded Warrants, and the Series L Warrants.

Taxation of the Depositary Shares and Pre-Funded Warrants

Dividends and Other Distributions on the Depositary Shares and Pre-Funded Warrants. Subject to the discussion above under the heading “-Passive Foreign Investment Company Considerations”, generally the gross amount of distributions made by us, if any, to a U.S. Holder with respect
to the Depositary Shares or the Pre-Funded Warrants, before reduction for any non-U.S. taxes withheld therefrom, will
be includable in gross income as a dividend to the extent that such distribution is paid out of our current or accumulated earnings and
profits (as determined under United States federal income tax principles). To the extent, if any, that the amount of any cash distribution
exceeds our current and accumulated earnings and profits, it will be treated first as a tax-free return of such U.S. Holder’s
tax basis in its Depositary Shares or Pre-Funded Warrants (as applicable), and to the extent the amount of the distribution
exceeds such U.S. Holder’s tax basis, the excess will be taxed as capital gain. We do not intend to calculate our earnings and profits
under United States federal income tax principles. Therefore, a U.S. Holder should expect that a distribution will generally be treated
as a dividend even if that distribution would otherwise be treated as a non-taxable return of capital or as capital gain under
the rules described above. A dividend in respect of the Depositary Shares or Pre-Funded Warrants (as applicable) will not be
eligible for the dividends-received deduction allowed to corporations in respect of dividends received from other United States corporations. Non-corporate U.S.
Holders may qualify for the lower rates of taxation with respect to