Company: SHPH
Filing Date: 2025-02-13
Form Type: S-1
Source: 0001493152-25-006202
Chunk: 79

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-02-13
Form: S-1
Chunk 79
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 according to the American Cancer Society (ACS), more than 90% of colorectal cancer patients are individuals aged 50 years and older, with approximately 40% of all cases occurring in patients aged 75 years and over. The Colon Cancer Alliance estimates that 90% of new cases and 95% of deaths from colorectal cancers occur in people aged 50 or older. Also, the U.S. Census estimates that the age group of 65-84 will grow by 23% within the next five years, indicating a likely increase in the overall number of cancer patients in the U.S.

| 49 |

The table below details the number of cancers estimated in the United States in 2024:

<div align='center'>Estimated New Cancer Cases in the U.S.</div>

| Male                  |     |         |     |    |   |     | Female                |     |         |     |    |   |
| Prostate              |     | 299,010 |     | 27 | % |     | Breast                |     | 310,720 |     | 31 | % |
| Lung & bronchus       |     | 116,310 |     | 12 | % |     | Lung & bronchus       |     | 118,270 |     | 13 | % |
| Colon & rectum        |     |  81,540 |     |  8 | % |     | Colon & rectum        |     |  71,270 |     |  8 | % |
| Urinary bladder       |     | 118,330 |     |  6 | % |     | Uterine corpus        |     |  67,880 |     |  7 | % |
| Melanoma of the skin  |     |  59,170 |     |  6 | % |     | Melanoma of the skin  |     |  41,470 |     |  5 | % |
| Kidney & renal pelvis |     |  52,380 |     |  5 | % |     | Thyroid               |     |  31,520 |     |  3 | % |
| Non-Hodgkin lymphoma  |     |  44,590 |     |  4 | % |     | Non-Hodgkin lymphoma  |     |  36,030 |     |  4 |