Company: CERO
Filing Date: 2025-02-07
Form Type: 424B3
Source: 0001213900-25-011071
Chunk: 69

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-02-07
Form: 424B3
Chunk 69
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 materials to support clinical or commercial manufacturing.

In addition, some of our
raw materials are currently available from a single supplier, or a small number of suppliers. For example, the type of cell culture media
and cryopreservation buffer that we currently use in our manufacturing process for the CER-T cells are available from multiple suppliers,
but each version may perform differently, requiring us to characterize them and modify our protocols if we change suppliers. Disruption
of our cell manufacturing process may affect product health, fitness, and potentially anti-tumor activity and clinical responses. In
addition, the cell processing equipment and tubing that we use in our current manufacturing process is only available from a single supplier.
We also use certain biologic materials, including certain activating antibodies, that are available from multiple suppliers, but each
version may perform differently, requiring us to characterize them and potentially modify some of our protocols if we change suppliers.
We cannot be sure that these suppliers will remain in business, or that they will not be purchased by one of our competitors or another
company that is not interested in continuing to produce these materials for our intended purpose. If we are required to change suppliers,
the materials may only be available from another supplier on terms that are less favorable to us than the terms under which we currently
obtain the materials. Accordingly, if we no longer have access to these suppliers, we may experience delays in our clinical or commercial
manufacturing which could harm our business or results of operations.

If we or our third-party suppliers use hazardous, non-hazardous, biological or other materials in a manner that causes injury or violates applicable law, we may be liable for damages.

Our R&D activities involve
the controlled use of potentially hazardous substances, including chemical and biological materials. We and our suppliers are subject
to federal, state and local laws and regulations in the United States governing the use, manufacture, storage, handling and disposal
of medical and hazardous materials. Although we believe that we and our suppliers’ procedures for using, handling, storing and
disposing of these materials comply with legally prescribed standards, we and our suppliers cannot completely eliminate the risk of contamination
or injury resulting from medical or hazardous materials. As a result of any such contamination or injury, we may incur liability or local,
city, state or federal authorities may curtail the use of these materials and interrupt our business operations. In the event of an accident,
we could be held liable for damages or penalized with fines, and the liability could exceed our resources. We do not