Company: SCLXW
Filing Date: 2025-09-29
Form Type: 424B3
Source: 0001193125-25-221018
Chunk: 67

Company: Scilex Holding Co
Filing Date: 2025-09-29
Form: 424B3
Chunk 67
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 as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing. Item 9.01. Financial Statements and Exhibits. (d) Exhibits.

| Exhibit 
 Number  
 10.1#   
 99.1    |     | Description                                                                                                          
 Securities Purchase Agreement, dated September 25, 2025, by and between Scilex Holding Company and Datavault AI Inc. 
 Press release dated September 25, 2025.                                                                              |
|:--------|:----|:---------------------------------------------------------------------------------------------------------------------|
| 99.2    |     | Press release dated September 26, 2025.                                                                              |
| 104     |     | Cover Page Interactive Data File, formatted in Inline Extensible Business Reporting Language (iXBRL).                |

| 

# | Certain of the exhibits and schedules to this Exhibit have been omitted in accordance with Regulation S-K Item 601. The Company agrees to furnish a copy of all omitted exhibits and schedules to the SEC upon its request. |
3

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

| SCILEX HOLDING COMPANY |     |                                       |
| By:                    |     | /s/ Henry Ji                          |
| Name:                  |     | Henry Ji                              |
| Title:                 |     | Chief Executive Officer and President |

Date: September 26, 2025 4

Exhibit 10.1

SECURITIES PURCHASE AGREEMENT

This Securities Purchase Agreement (this “”) is dated as of September 25, 2025, between
Datavault AI Inc., a Delaware corporation (the “”), and Scilex Holding Company, a Delaware corporation (including its successors and assigns, the “”).

WHEREAS, subject to the terms and conditions set forth in this Agreement and pursuant to an effective registration statement
under the Securities Act (as defined below), the Company desires to issue and sell to the Purchaser, and the Purchaser, severally and not jointly, desires to purchase from the Company, Shares (as defined below) and the
Pre-Funded Warrant (as defined below) of the Company as more fully described in this Agreement; and

WHEREAS, on the Initial Closing Date (as defined below) and as a condition and inducement to the Purchaser’s willingness
to enter into