Company: PRME
Filing Date: 2025-02-28
Form Type: S-8
Source: 0001628280-25-008885
Chunk: 0

Company: Prime Medicine, Inc.
Filing Date: 2025-02-28
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on February 28, 2025</div>

#### Registration No. 333-

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549

#### FORM S-8

### REGISTRATION STATEMENT

#### Under

#### The Securities Act of 1933

#### Prime Medicine, Inc.
<div align='center'>(Exact name of registrant as specified in its charter)</div>

| Delaware                        |     | 84-3097762            |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -I.R.S. Employer      
 Identification Number |

#### 60 First Street

#### Cambridge, MA 02141
<div align='center'>(617) 465-0013

(Address of Principal Executive Offices)

Prime Medicine, Inc. 2022 Stock Option and Incentive Plan

(Full Title of the Plan)</div>

#### Keith Gottesdiener, M.D.

#### President and Chief Executive Officer

#### Prime Medicine, Inc.

#### 60 First Street

#### Cambridge, MA 02141
<div align='center'>(617) 465-0013

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copies to:</div>

#### Kingsley L. Taft, Esq.

#### Marishka DeToy, Esq.

#### Goodwin Procter LLP

#### 100 Northern Avenue

#### Boston, Massachusetts 02210
<div align='center'>(617) 570-1000</div>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer |     | ☐ |     | Accelerated 
 filer       |     | ☐ |     | Non-accelerated filer |     | ☒ |     | Smaller reporting company |     | ☒ |     | Emerging growth company |     | ☒ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new