Company: CSTL
Filing Date: 2025-03-28
Form Type: PRE 14A
Source: 0001447362-25-000050
Chunk: 39

Company: CASTLE BIOSCIENCES INC
Filing Date: 2025-03-28
Form: PRE 14A
Chunk 39
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 discretion to abandon the Officer Exculpation Amendment and not implement it at any time before it becomes effective. If the stockholders do not approve this proposal, the amendment and restatement of the Restated Certificate to reflect the Officer Exculpation Amendment will not be filed with the Delaware Secretary of State and will not become effective.

#### Vote Required for Adoption
Approval and adoption of the amendment and restatement of the Restated Certificate to reflect the Officer Exculpation Amendment, and of this proposal, requires the affirmative vote of the holders of a majority of the outstanding shares of our common stock entitled to vote thereon.

| FOR |     | The Board of Directors Recommends a Vote“FOR”Approval of the Officer Exculpation Amendment. |

#### 41Castle Biosciences 2025 Proxy Statement
| Security Ownership of Certain Beneficial Owners and Management |

The following table sets forth certain information regarding the ownership of the Company’s common stock as of March 21, 2025 by (i) each of our directors; (ii) each of our NEOs; (iii) all of our current executive officers and directors as a group; and (iv) all those known by the Company to be beneficial owners of more than 5% of its common stock. Applicable percentages are based on 28,839,188 shares outstanding on March 21, 2025, adjusted as required by rules promulgated by the SEC. Except as otherwise noted below, the address for each person or entity listed in the table is c/o Castle Biosciences, Inc., 505 S. Friendswood Drive, Suite 401, Friendswood, Texas 77546.

We have determined beneficial ownership in accordance with the rules of the SEC. These rules generally attribute beneficial ownership of securities to persons who possess sole or shared voting power or investment power with respect to those securities. In addition, the rules include shares of common stock issuable pursuant to the exercise of stock options or RSUs that are either immediately exercisable or settleable or exercisable or settleable on or before May 20, 2025, which is 60 days after March 21, 2025. These shares are deemed to be outstanding and beneficially owned by the person holding those options or RSUs for the purpose of computing the percentage ownership of that person, but they are not treated as outstanding for the purpose of computing the percentage ownership of any other person. Unless otherwise indicated, the persons or entities identified in this table have sole voting and