Company: INTS
Filing Date: 2025-04-25
Form Type: 424B4
Source: 0001628280-25-020056
Chunk: 3

Company: INTENSITY THERAPEUTICS, INC.
Filing Date: 2025-04-25
Form: 424B4
Chunk 3
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%) of the aggregate purchase price paid by investors in this offering. See “Plan of Distribution” for additional disclosure regarding compensation payable to the Placement Agents.

(3) Does not include proceeds from the exercise of the Common Warrants in cash, if any.

Delivery of the securities is expected to be made on or about April 28, 2025, subject to satisfaction of certain conditions.

<div align='center'>Lead Placement Agent</div>

#### A.G.P.
<div align='center'>Co-Placement Agent</div>

#### Brookline Capital Markets,
<div align='center'>a division of Arcadia Securities, LLC</div>

#### The date of this prospectus is April 24, 2025

### TABLE OF CONTENTS
| ABOUT THIS PROSPECTUS                                    |     | ii |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS        |     |  1 |
| PROSPECTUS SUMMARY                                       |     |  3 |
| THE OFFERING                                             |     |  6 |
| RISK FACTORS                                             |     |  8 |
| USE OF PROCEEDS                                          |     | 12 |
| MARKET FOR COMMON STOCK AND DIVIDEND POLICY              |     | 13 |
| DESCRIPTION OF OUR CAPITAL STOCK                         |     | 16 |
| DESCRIPTION OF SECURITIES TO BE REGISTERED               |     | 20 |
| MATERIAL UNITED STATES FEDERAL INCOME TAX CONSIDERATIONS |     | 23 |
| PLAN OF DISTRIBUTION                                     |     | 30 |
| LEGAL MATTERS                                            |     | 33 |
| EXPERTS                                                  |     | 33 |
| WHERE YOU CAN FIND ADDITIONAL INFORMATION                |     | 33 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE        |     | 34 |

<div align='center'>i</div>

### ABOUT THIS PROSPECTUS
You should rely only on the information that we have provided or incorporated by reference in this prospectus. We have not authorized anyone to provide you with different or additional information. If anyone provides you with different or additional information, you should not rely on it. You should assume that the information in this prospectus is accurate only as of the date on the cover of the document and that any information we have incorporated by reference is accurate only as of the date of the document incorporated by reference, regardless of the time of delivery of this prospectus or any sale of a security. Our business, financial condition, results of operations