Company: EDSA
Filing Date: 2025-07-25
Form Type: S-3
Source: 0001171843-25-004721
Chunk: 43

Company: Edesa Biotech, Inc.
Filing Date: 2025-07-25
Form: S-3
Chunk 43
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, officer or controlling person in connection with the securities being       
 registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to        
 a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act         
 and will be governed by the final adjudication of such issue.                                                                                |
| (8) | The undersigned hereby undertakes to file an application for the purpose of determining the eligibility                                      
 of the trustee to act under subsection (a) of Section 310 of the Trust Indenture Act in accordance with the rules and regulations prescribed 
 by the SEC under Section 305(b)(2) of the Act.                                                                                               |

| II-5 |

<div align='center'>SIGNATURES</div>

Pursuant to the requirements
of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the
requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the city of Markham, Ontario, on July 25, 2025.

| EDESA BIOTECH, INC. |                                                           |
| By:                 | /s/ Pardeep Nijhawan                                      |
|                     | Pardeep Nijhawan                                          |
|                     | Director, Chief Executive Officer and Corporate Secretary |

KNOW ALL MEN BY THESE PRESENTS, that we, the undersigned officers and directors Edesa Biotech, Inc. (the “ Company”), do hereby constitute and appoint each Pardeep Nijhawan and Peter Weiler as his or her true and lawful attorney-in-fact and agent, with full power of substitution and re-substitution, for him or her and in his or her name, place, and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments, exhibits thereto and other documents in connection therewith) to this registration statement and any subsequent registration statement filed by the registrant pursuant to Rule 462(b) of the Securities Act of 1933, as amended, which relates to this registration statement, and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto each said attorney-in-fact and agent full power and authority to do and perform each and every act and thing