Company: CYTK
Filing Date: 2025-02-27
Form Type: S-3ASR
Source: 0001193125-25-039426
Chunk: 3

Company: CYTOKINETICS INC
Filing Date: 2025-02-27
Form: S-3ASR
Chunk 3
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 options to purchase additional shares will be set forth in a prospectus supplement. The price to the public of such securities and
the net proceeds we expect to receive from such sale will also be set forth in a prospectus supplement. Unless the applicable prospectus supplement provides otherwise, we will not receive any proceeds from the sale of securities by selling
securityholders.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is February 27, 2025

TABLE OF CONTENTS

|                                                   |     | Page |    |
| ABOUT THIS PROSPECTUS                             |     |      | ii |
| PROSPECTUS SUMMARY                                |     |      |  1 |
| RISK FACTORS                                      |     |      |  5 |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |      |  6 |
| USE OF PROCEEDS                                   |     |      |  8 |
| DESCRIPTION OF CAPITAL STOCK                      |     |      |  9 |
| DESCRIPTION OF DEBT SECURITIES                    |     |      | 13 |
| DESCRIPTION OF WARRANTS                           |     |      | 20 |
| LEGAL OWNERSHIP OF SECURITIES                     |     |      | 22 |
| SELLING SECURITYHOLDERS                           |     |      | 25 |
| PLAN OF DISTRIBUTION                              |     |      | 26 |
| LEGAL MATTERS                                     |     |      | 28 |
| EXPERTS                                           |     |      | 28 |
| WHERE YOU CAN FIND MORE INFORMATION               |     |      | 29 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE |     |      | 30 |

i

ABOUT THIS PROSPECTUS

This prospectus is part of an automatic registration statement on Form S-3 that we filed
with the Securities and Exchange Commission, or the SEC, utilizing a “shelf” registration process as a “well-known seasoned issuer,” as defined in Rule 405 under the Securities Act of 1933, as amended, or the Securities Act.
Under this shelf registration statement, we or selling securityholders may offer and sell shares of our common stock and preferred stock, various series of debt securities and/or warrants to purchase any of such securities, either individually or in
combination with other securities, in one or more