Company: LENZ
Filing Date: 2025-04-04
Form Type: POS AM
Source: 0001628280-25-016813
Chunk: 3

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-04
Form: POS AM
Chunk 3
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 the section titled “ Use of Proceeds ” appearing elsewhere in this prospectus.

The selling securityholders may sell the securities described in this prospectus in a number of different ways and at varying prices. We provide more information about how the selling securityholders may sell their securities in the section titled “ Plan of Distribution ” appearing elsewhere in this prospectus.

The selling securityholders may sell any, all or none of the securities and we do not know when or in what amount the selling securityholders may sell their securities hereunder following the effective date of this registration statement.

Our Common Stock is listed on The Nasdaq Global Select Market (“Nasdaq”) under the symbol “LENZ.” On April 3, 2025, the last quoted sale price for our Common Stock as reported on Nasdaq was $23.00.

We are an “emerging growth company,” as defined under the federal securities laws, and, as such, may elect to comply with certain reduced public company reporting requirements for future filings.

Investing in our securities involves a high degree of risk. Before buying any securities, you should carefully read the discussion of the risks of investing in our securities in the section titled “

#### Risk Factors

#### ” beginning on page

#### 6
of this prospectus and under similar headings in any amendments or supplements to this prospectus and the documents incorporated herein by reference.

You should rely only on the information contained in this prospectus or any prospectus supplement or amendment hereto. We have not authorized anyone to provide you with different information.

Neither the Securities Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is , 2025.</div>

### TABLE OF CONTENTS
|                                                      |     | Page |
| About This Prospectus                                |     |   ii |
| Market and Industry Data                             |     |  iii |
| Trademarks                                           |     |   iv |
| The Company                                          |     |    1 |
| The Offering                                         |     |    3 |
| Risk Factors Summary                                 |     |    4 |
| Risk Factors                                         |     |    6 |
| Cautionary Note Regarding Forward-Looking Statements |     |    7 |
| Use of Proceeds                                      |     |    9 |
| Selling Securityholders                              |     |   10 |
| Description of Securities                            |