Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 80

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 80
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 and the impact of such a classification.

Information Reporting Requirements

If we are a PFIC for any taxable year during which a U.S. Holder holds the ADSs, the Pre-Funded
Warrants, or the Warrants, each such U.S. Holder generally will be required to file an annual information return on IRS Form 8621 containing such information as the U.S. Treasury Department may require. The failure to file IRS Form 8621 could result
in the imposition of penalties and the extension of the statute of limitations with respect to U.S. federal income tax.

The U.S. federal
income tax rules relating to PFICs are complex. U.S. Holders are urged to consult their tax advisors with respect to the purchase, ownership and disposition of the ADSs, the Pre-Funded Warrants, and the
Warrants, the availability of the mark-to-market election and whether making the election would be advisable in their particular circumstances, and the IRS information
reporting obligations with respect to the purchase, ownership and disposition of the ADSs, the Pre-Funded Warrants, and the Warrants.

Taxation of the ADSs and Pre-FundedWarrants

Dividends and Other Distributions on the ADSs and Pre-FundedWarrants

Subject to the discussion above under the heading “-Passive Foreign Investment Company Considerations”, generally the gross amount of
distributions made by us, if any, to a U.S. Holder with respect to the ADSs or the Pre-Funded Warrants, before reduction for any non-U.S. taxes withheld therefrom, will
be includable in gross income as a dividend to the extent that such distribution is paid out of our current or accumulated earnings and profits (as determined under U.S. federal income tax principles). To the extent, if any, that the amount of any
cash distribution exceeds our current and accumulated earnings and profits, it will be treated first as a tax-free return of such U.S. Holder’s tax basis in its ADSs or
Pre-Funded Warrants (as applicable), and to the extent the amount of the distribution exceeds such U.S. Holder’s tax basis, the excess will be taxed as capital gain. We do not intend to calculate our
earnings and profits under U.S. federal income tax principles. Therefore, a U.S. Holder should expect that a distribution will generally be treated as a dividend even if that distribution would otherwise be treated as a non-taxable return of capital or as capital gain under