Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 35

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 35
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 been authorized by the board of directors.

(b) Subject to the provisions of any
relevant legislation and provided that he or she has disclosed to the directors the nature and extent of any material interest of his or hers, a director may be a party to, or otherwise interested in, any transaction, contract or arrangement and
that director shall not, by reason of his or her office, be accountable to the company for any benefit that he or she derives from any such transaction or arrangement; and no such transaction or arrangement shall be liable to be voided on the ground
of any such interest or benefit.

(c) Except as provided in our articles of association, a director shall not vote at a meeting of the
directors in respect of any transaction or arrangement or any other proposal whatsoever in which he or she has an interest that is to his or her knowledge material (together with any person connected with him or her within the meaning of section 252
of the Companies Act 2006), other than (i) an interest in shares or debentures or other securities of the company, (ii) where permitted by the terms of any authorization of a conflict of interest, or (iii) in the circumstances set out
in paragraph (d) below, and shall not be counted in the quorum at a meeting in relation to any resolution on which he or she is not entitled to vote.

23

Confidential Treatment Requested by Nucana plc

Pursuant to 17 C.F.R. Section 200.83

(d) A director shall (in the absence of some material interest other than those indicated
below) be entitled to vote (and be counted in the quorum) in respect of any resolution concerning any of the following matters:

(i) the giving of any guarantee, security or indemnity to him or her in respect of money lent to or an obligation incurred by
him or her at the request of or for the benefit of us or any of our subsidiaries;

(ii) the giving to a third party of any
guarantee, security or indemnity in respect of a debt or obligation of ours or any of our subsidiaries for which he himself or she herself has assumed responsibility in whole or in part under a guarantee or indemnity or by the giving of security;

(iii) any proposal or contract concerning an offer of shares or debentures or other securities of or by the company or any
of its subsidiaries, if he or she takes part because he or she is or may be entitled to participate