Company: CERO
Filing Date: 2025-10-23
Form Type: 424B3
Source: 0001213900-25-101650
Chunk: 10

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-10-23
Form: 424B3
Chunk 10
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 part on representations made by the PIPE Investors. The securities may not be offered
or sold in the United States absent registration or an applicable exemption from registration requirements. Neither this Current Report
on Form 8-K, nor the exhibits attached hereto, is an offer to sell or the solicitation of an offer to buy the securities described herein.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

The following exhibits are being filed herewith:

| Exhibit No. 
 3.1†        
 10.1*†      |     | Document                                                                                                                                          
 Form of Certificate of Designation of Preferences, Rights and Limitations of the Series E Convertible Preferred Stock.                            
 Securities Purchase Agreement, dated as of October 14, 2025, by and between CERo Therapeutics Holdings, Inc. and the investors signatory thereto. |
|:------------|:----|:--------------------------------------------------------------------------------------------------------------------------------------------------|
| 10.2*       |     | Form of Registration Rights Agreement by and between CERo Therapeutics Holdings, Inc. and the investors signatory thereto.                        |
| 104         |     | Cover Page Interactive Data File (embedded within the Inline XBRL document).                                                                      |

| * | Schedules and exhibits have been omitted pursuant to Item                                                             
 601(a)(5) of Regulation S-K. A copy of any omitted schedule and/or exhibit will be furnished to the SEC upon request. |

| † | Certain portions of this document that constitute confidential                
 information have been redacted pursuant to Item 601(b)(10) of Regulation S-K. |

<div align='center'>4</div>

Forward-Looking Statements

This Current Report on Form 8-K contains statements
that are forward-looking and as such are not historical facts. This includes, without limitation, statements regarding (i) the expected
cash proceeds of the Private Placement and the timing of the closing of the Private Placement, and (ii) financial position, business strategy
and the plans and objectives of management for future operations of the Company, and the implementation of its proposed plan of compliance
with Nasdaq continued listing standards. These statements constitute projections, forecasts and forward-looking statements, and are not
guarantees of performance. Such statements can be identified by the fact that they do not relate strictly to historical or current facts.
When used in this communication, words such as “anticipate,” “believe,” “continue,” “could,”
“estimate,” “expect,” “int