Company: GLPI
Filing Date: 2025-08-13
Form Type: 424B5
Source: 0001193125-25-179509
Chunk: 8

Company: Gaming & Leisure Properties, Inc.
Filing Date: 2025-08-13
Form: 424B5
Chunk 8
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 our ability to retain our key management personnel; |

| • |     | changes in the U.S. tax law and other federal, state or local laws or regulations, whether or not specific to 
 real estate, REITs or the gaming, lodging or hospitality industries;                                          |

| • |     | changes in accounting standards; |

| • |     | the impact of weather or climate events or conditions, natural disasters, acts of terrorism and other                                                           
 international hostilities, including war (including the current conflict between Russia and Ukraine and conflicts in the Middle East) or political instability; |

| • |     | the risk that the historical financial statements included and incorporated by reference herein do not reflect 
 what the business, financial position or results of operations of GLPI may be in the future; and               |

| • |     | other risks inherent in the real estate business, including potential liability relating to environmental matters 
 and illiquidity of real estate investments.                                                                       |

While forward-looking statements reflect our good faith beliefs, they are not guarantees of future performance. We expressly disclaim any obligation to publicly update or revise any forward-looking statement to reflect changes in underlying assumptions or factors, or new information, data or methods, future events or other changes. Accordingly, investors should use caution in relying on past forward-looking statements, which were based on results and trends at the time they were made, to anticipate future results or trends. For a further discussion of these and other factors that could impact our future results, performance or transactions, see the section of this prospectus supplement titled “Risk Factors”, as well as the risks incorporated by reference herein from our Annual Report on Form 10-K forthe year ended December 31, 2024 (“2024 10-K”) andother reports filed with the SEC. S-vi

PROSPECTUS SUPPLEMENT SUMMARY This summary highlights selected information contained elsewhere in this prospectus supplement, in the accompanying prospectus and in the documents incorporated by reference herein and therein, and does not contain all of the information that may be important to you. You should carefully read this entire prospectus supplement, the accompanying prospectus and the documents incorporated herein and therein by reference, including the “Risk Factors” section beginning on page S-[10] ofthis prospectus supplement, as well as the risks incorporated by reference from our 2024 10-K, beforemaking an investment decision regarding the notes. About the Company GLPI is a self-administered and self-managed REIT, the primary business of