Company: SCLXW
Filing Date: 2025-12-16
Form Type: S-1
Source: 0001193125-25-319720
Chunk: 626

Company: Scilex Holding Co
Filing Date: 2025-12-16
Form: S-1
Chunk 626
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 Incentive Plan (the “Equity Incentive Plan”). As of September 30, 2025, atotal of 725,397 shares of Common Stock were available and have been reserved for future issuance under the Equity Incentive Plan. Scilex Holding Company 2023 Inducement Plan On January 17, 2023, the compensation committee of the Board adopted the Scilex Holding Company 2023 Inducement Plan (the “Inducement Plan”). The Inducement Plan provides for the grant of equity-based awards in the form of non-statutorystock options, stock appreciation rights, restricted stock, restricted stock units, and other awards solely to prospective employees of the Company or an affiliate of the Company provided that certain criteria are met. The initial maximum number of shares available for grant under the Inducement Plan is 40,000 shares of Common Stock (subject to adjustment for recapitalizations, stock splits, reorganizations and similar transactions). No awards were granted under the Inducement Plan during the nine months ended September 30, 2025 and 2024. As of September 30, 2025, options to purchase 1,000,626shares of Common Stock were outstanding under all equity incentive plans. F-9 7

The following table summarizes stock option activity during the nine months ended September 30, 2025 (in thousands, except for per share amounts and contractual life):

|                                                      |     | Options |       |   |     | Weighted-AverageExercise Price |        |     | Weighted-AverageRemainingContractual Life,in years |     |     | AggregateIntrinsic Value |    |
|:-----------------------------------------------------|:----|:--------|------:|:--|:----|:-------------------------------|-------:|:----|:---------------------------------------------------|----:|:----|:-------------------------|---:|
| Outstanding as of December 31, 2024                  |     |         | 1,028 |   |     | $                              | 138.23 |     |                                                    | 6.4 |     | $                        |  — |
| Granted                                              |     |         |     3 |   |     | $                              |  15.99 |     |                                                    |     |     |                          |    |
| Forfeited/Cancelled                                  |     |         |   (30 | ) |     | $                              |  95.21 |     |                                                    |