Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 37

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 37
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 into an
ordinary share (nominal value £0.04 per share), immediately prior to this conversion, on October 2, 2017, we allotted to holders of series B convertible participating shares an additional nine series B convertible participating shares for
each series B convertible participating share held.

On October 2, 2017, we issued 7,596,505 ordinary shares pursuant to our initial
public offering.

During 2018 we issued 415,312 ordinary shares pursuant to the exercise of share options.

During 2019 we issued 252,187 ordinary shares pursuant to the exercise of share options.

On September 21, 2020, we issued 17,888,889 ordinary shares pursuant to our follow-on public
offering.

During 2020 we issued 774,511 ordinary shares pursuant to our
“at-the-market” (ATM) sales agreement.

During
2020 we issued 32,500 ordinary shares pursuant to the exercise of share options.

During 2021 we issued 1,005,434 ordinary shares pursuant
to the exercise of share options.

During 2022 we issued 192,908 ordinary shares pursuant to the exercise of share options.

During 2023 we issued 408,015 ordinary shares pursuant to our ATM sales agreement, and 79,433 ordinary shares pursuant to the exercise of
share options.

During 2024, we issued 89,027,545 ordinary shares pursuant to our ATM sales agreement, and 149,319 ordinary shares
pursuant to the exercise of share options.

Subsequent to December 31, 2024, we issued 9,857,575 ordinary shares pursuant to our ATM
sales agreement, and 29,123 ordinary shares pursuant to the exercise of share options.

On April 23, 2025, we subdivided and
redesignated the issued share capital of the 151,923,897 ordinary shares of £0.04 each into 151,923,897 ordinary shares and 15,040,465,803 deferred shares, in each case, of £0.0004 each.

21

Ordinary Shares

As of December 31, 2024, we had issued and outstanding 142,037,199 ordinary shares of £0.04 each. Each issued ordinary share is
fully paid.

Holders of ordinary shares are entitled to one vote for each share held of record on all matters submitted to a vote of
shareholders and do not have cumulative