Company: XXII
Filing Date: 2025-06-20
Form Type: S-3
Source: 0001641172-25-015905
Chunk: 20

Company: 22nd Century Group, Inc.
Filing Date: 2025-06-20
Form: S-3
Chunk 20
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 are considered part of this                                        
 prospectus;                                                                               |
| ● | we are disclosing important information to you by referring                               
 you to those documents; and                                                               |
| ● | information we file with                                                                  
 the SEC will automatically update and supersede information contained in this prospectus. |

We incorporate by reference the documents listed below and any future filings we make with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act (in each case, other than information furnished under Item 2.02 or Item 7.01 of Form 8-K) (i) after the date of the registration statement on Form S-3 filed under the Securities Act with respect to securities offered by this prospectus and prior to the effectiveness of such registration statement and (ii) after the date of this prospectus and before the end of the offering of the securities pursuant to this prospectus:

| ● 
 ● | Our                                                                                                                                        
 Annual Report on Form 10-K for the fiscal year ended December 31, 2024 filed with the SEC on March 20, 2025, as amended on April 30, 2025; 
 Our Quarterly Reports on                                                                                                                   
 Form 10-Q for the periods ended March 31, 2025 filed with the SEC on May 13, 2025;                                                         |
|:--|:-------------------------------------------------------------------------------------------------------------------------------------------|
| ● | Our Current Reports on                                                                                                                     
 Form 8-K filed with the SEC on January 7, 2025, January 13, 2025, January 27, 2025, April 30, 2025, May 22, 2025, and June 16, 2025;       
 and                                                                                                                                        |

| 11 |

Information in this prospectus supersedes related information in the documents listed above, and information in subsequently filed documents supersedes related information in both this prospectus and the incorporated documents.

We will promptly provide, without charge to you, upon written or oral request, a copy of any or all of the documents incorporated by reference in this prospectus, other than exhibits to those documents, unless the exhibits are specifically incorporated by reference in those documents. Requests should be directed to:

<div align='center'>22nd Century Group, Inc.

321 Farmington Rd

Mocksville, NC 27028

(336) 940-3769</div>

You can also find these filings on our website at www.xxiicentury.com. We