Company: SNSE
Filing Date: 2025-03-28
Form Type: S-8
Source: 0000950170-25-046346
Chunk: 1

Company: Sensei Biotherapeutics, Inc.
Filing Date: 2025-03-28
Form: S-8
Chunk 1
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 emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.¨

<div align='center'>EXPLANATORY NOTE</div>

This Registration Statement on Form S-8 is being filed for the purpose of registering an additional (i) 1,007,223 shares of Common Stock of Sensei Biotherapeutics, Inc. to be issued pursuant to the 2021 Equity Incentive Plan (“2021 EIP”) and (ii) 251,805 shares of Common Stock of Sensei Biotherapeutics, Inc. (the “Registrant”) to be issued pursuant to the 2021 Employee Stock Purchase Plan (the “2021 ESPP”), pursuant to the provisions of the 2021 EIP and 2021 ESPP providing for automatic increases in the number of shares of Common Stock reserved and available for issuance under the 2021 EIP and 2021 ESPP on January 1, 2025. In accordance with the instructional note to Part I of Form S-8 as promulgated by the Securities and Exchange Commission (the “Commission”), the information specified by Part I of the Form S-8 has been omitted from this Registration Statement.

PART II ITEM 3. INCORPORATION OF DOCUMENTS BY REFERENCE

The contents of the earlier registration statement relating to (i) the 2018 Stock Incentive Plan, (ii) the 2021 EIP and (iii) the 2021 ESPP, previously filed with the Commission on February 10, 2021 (File No. 333-252954) are incorporated herein by reference and made a part of this Registration Statement.

ITEM 8. EXHIBITS Incorporated by Reference

| ExhibitNumber | Description                                                                                                    | ScheduleForm | File Number | Exhibit | Filing Date |
| 4.1           | Amended and Restated Certificate of Incorporation.                                                             | 8-K          | 001-39980   |     3.1 | 02/11/2021  |
| 4.2           | Amended and Restated Bylaws.                                                                                   | 8-K          | 001-39980   |     3.2 | 02/11/2021  |
| 4.3           | Certificate of Designations of the Series A Junior Participating