Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 26

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 26
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14 to
1-for-50, with such ratio to be determined ultimately by the Board. On April 3, 2025, the Board approved the Reverse Stock Split ratio of 1-for-35. The Company effected the Reverse Stock Split on April 15, 2025 in order to demonstrate compliance with Nasdaq’s Minimum Bid Price Requirement prior to the
end of the Compliance Period, in accordance with Nasdaq rules.

As a result of the Reverse Stock Split, the Company’s outstanding
Common Stock was reduced from approximately 243,312,885 shares to approximately 6,951,671 shares, based on the number of shares of Common Stock outstanding as of April 14, 2025. Unless indicated otherwise, all share and per share information
presented in this prospectus reflects the completion of the Reverse Stock Split. The Company’s historical financial statements included in this prospectus do not reflect the Reverse Stock Split. No fractional shares were issued in connection
with the Reverse Stock Split. Instead, each fractional share remaining after completion of the reverse share split that was less than a whole share was rounded down and canceled in exchange for an amount in cash (without interest or deduction) equal
to the fraction of one share to which such stockholder would otherwise be entitled multiplied by the closing price of the Common Stock on The Nasdaq Capital Market on the last trading day immediately preceding the effectiveness of the Reverse Stock
Split. The Reverse Stock Split was applied to all the Company’s outstanding Common Stock and therefore did not affect any shareholder’s ownership percentage of the shares, except for changes as a result of the elimination of fractional
shares. The Reverse Stock Split did not alter the voting rights attached to the shares. On April 30, 2025, the Company received notice from Nasdaq that it had regained compliance with the Minimum Bid Price Requirement under Nasdaq Listing Rule
5550(a)(2).

17

Emerging Growth Company We are an “emerging growth company,” as defined in Section 2(a) of the Securities Act, as modified by the JOBS Act. As an emerging growth company, we are eligible to take advantage of certain exemptions from various reporting requirements that are applicable to other public companies that are not emerging growth companies, including, but not limited to, not being required to comply with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act of 2002, as amended (the “Sarbanes-Oxley Act”), reduced disclosure obligations regarding executive compensation in