Company: CSTL
Filing Date: 2025-04-09
Form Type: DEF 14A
Source: 0001447362-25-000054
Chunk: 105

Company: CASTLE BIOSCIENCES INC
Filing Date: 2025-04-09
Form: DEF 14A
Chunk 105
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AGAINST” and abstentions; and (iii) with respect to Proposals 3 and 4, votes “FOR” and “AGAINST,” abstentions and broker non-votes.

#### What are “broker non-votes”?
When a beneficial owner of shares held in “street name” does not give instructions to the brokerage firm, bank, dealer or other agent holding the shares as to how to vote on matters deemed to be non-routine under applicable NYSE rules, the broker or nominee cannot vote the shares. These unvoted shares are counted as “broker non-votes.”

| As a reminder, if you are a beneficial owner of shares held in street name, in order to ensure your shares are voted in the way you would prefer, youmustprovide voting instructions to your broker, bank or other agent by the deadline provided in the materials you receive from your broker, bank or other agent. |

#### 94Castle Biosciences 2025 Proxy Statement

#### Questions and Answers
How many votes are needed to approve each proposal?

The following table summarizes the minimum vote needed to approve each proposal and the effect of abstentions and broker non-votes:

| Proposal |     |   |     |                                                                                                                                                       |     | Vote Required for Approval                                                                                                                                                              |     | Effect of Abstentions |     | Effect of Broker Non-Votes |
|          |     | 1 |     | Election of Directors                                                                                                                                 |     | Nominees will be elected by a plurality of the votes of the shares present in person or represented by proxy at the meeting and entitled to vote generally on the election of directors |     | No effect             |     | No effect                  |
|          |     | 2 |     | Ratification of the selection of KPMG LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2025 |     | “FOR”votes from the holders of the majority of shares present in person, by remote communication, or represented by proxy and entitled to vote on the subject matter                    |     | Against               |     | Not applicable(1)          |
|          |     | 3 |     | Advisory approval of the compensation of our NEOs                                                                                                     |     | “FOR”votes from the holders of the majority of shares present in person, by remote communication, or represented by proxy and entitled to vote on the subject matter                    |     | Against               |     | No effect                  |
|          |     | 4 |     |