Company: TEM
Filing Date: 2025-02-25
Form Type: S-1
Source: 0001193125-25-034442
Chunk: 57

Company: Tempus AI, Inc.
Filing Date: 2025-02-25
Form: S-1
Chunk 57
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                    |           |     | % |     |     | Number  |   |     | % |   |     | Number               |           |     | %                         |   |     | Number  |   |     | % |   |     |   |
| REALM IDx, Inc.(1)          |     |                           | 4,843,136 |     |   | 2.9 |     |         | — |     |   | — |     |                      | 4,843,136 |     |                           | — |     |         | — |     |   | — |     | — |

| (1) | KMI, a publicly traded corporation organized under the laws of Japan and traded on the Tokyo Stock Exchange,                                                                                                                                              
 is the ultimate parent of, and may be deemed to have voting, investment and dispositive control over the Shares held by, REALM IDx, Inc. KMI is governed by its board of directors which consists of nine persons, none of which has beneficial ownership 
 over the Shares. The registered address of REALM IDx, Inc. is c/o Konica Minolta, 1900 S State College Blvd, Suite 600, Anaheim, California 92806.                                                                                                        |

38

CERTAIN MATERIAL U.S. FEDERAL INCOME TAX CONSEQUENCES FOR NON-U.S.HOLDERS The following summary describes certain material U.S. federal income tax consequences to Non-U.S.Holders (as defined below) of the ownership, and disposition of our Class A common stock acquired in this offering. For the avoidance of doubt, this discussion does not address U.S. federal income tax consequences of the issuance or receipt of our Class A Common Stock as stock consideration in connection with our acquisition of Ambry, as more fully described above in “Prospectus Summary—Acquisition of Ambry Genetics Corporation.” This discussion is not a complete analysis of all potential U.S. federal income tax consequences relating thereto, and does not address non-U.S.,state, and local tax consequences that may be relevant to Non-U.S.Holders in light of their particular circumstances, nor does it address U.S. federal tax consequences (such as gift and estate taxes) other than income taxes. This discussion is limited to Non-U.S.Holders that hold our Class A common stock as a “capital asset” within the meaning of Section 1221 of the Code (generally, property held for investment). This discussion does not address all U.S. federal