Company: FITBI
Filing Date: 2025-11-05
Form Type: S-4
Source: 0001193125-25-267273
Chunk: 5

Company: FIFTH THIRD BANCORP
Filing Date: 2025-11-05
Form: S-4
Chunk 5
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 meeting of Fifth Third voting shareholders will be held
virtually via the Internet on January 6, 2026 at www.virtualshareholdermeeting.com/FITB2026SM, at 9:00 a.m., Eastern Standard Time. The special meeting of holders of Comerica common stock will be held virtually via the Internet on
January 6, 2026 at www.meetnow.global/MPJJCLF, at 9:00 a.m., Eastern Standard Time.

Each of our boards of directors unanimously recommends that holders of voting stock vote “FOR” each of the proposals to be considered at the respective special meetings. We strongly support this combination of our companies and join our boards in their recommendations.

This joint proxy statement/prospectus provides you with detailed information about the merger agreement and the mergers. It also contains or references
information about Fifth Third and Comerica and certain related matters. You are encouraged to read this joint proxy statement/prospectus, including the related annexes and information incorporated herein by reference, carefully. In particular, you should read the “Risk Factors” section beginning on page50 for a discussion of the risks you should consider in evaluating the proposed mergers and how they will affect you. You can also obtain information about Fifth Third and Comerica

from documents that have been filed with the Securities and Exchange Commission that are incorporated into this joint proxy statement/prospectus by reference. On behalf of Fifth Third and Comerica, thank you for your prompt attention to this important matter.

| Timothy N. Spence Chairman, Chief Executive 
 Officer and President Fifth Third Bancorp   |     | Curtis C. Farmer Chairman, Chief Executive  
 Officer and President Comerica Incorporated |

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the securities to be issued in connection with the first merger or determined if this document is accurate or complete. Any representation to the contrary is a criminal offense. The securities to be issued in the first merger are not savings or deposit accounts or other obligations of any bank or non-banksubsidiary of either Fifth Third or Comerica, and they are not insured by the Federal Deposit Insurance Corporation or any other governmental agency. The accompanying joint proxy statement/prospectus is dated [ ], 2025, and is first being mailed to Fifth Third voting shareholders and Comerica stockholders on or about [ ], 2025.

ADDITIONAL INFORMATION This joint proxy statement/prospectus incorporates important business and financial information about Fifth