Company: SHPH
Filing Date: 2025-03-13
Form Type: 424B3
Source: 0001493152-25-010109
Chunk: 0

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-03-13
Form: 424B3
Chunk 0
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Filed pursuant to Section 424(b)(3)

Registration No. 333-284889

PROSPECTUS

<div align='center'>SHUTTLE PHARMACEUTICALS HOLDINGS, INC.

1,340,921 Shares of Common Stock

17,825,746 Pre-Funded Warrants to Purchase 17,825,746 Shares of Common Stock

17,825,746 Shares of Common Stock Underlying the Pre-Funded Warrants</div>

This is a firm commitment underwritten offering
of 1,340,921 shares (the “Shares”) of common stock, par value $0.00001 per share (“common stock”) and
17,825,746 pre-funded warrants to purchase shares common stock in lieu thereof (the “Pre-Funded Warrants”).

The public offering price for each share of common
stock or each Pre-Funded Warrant is $0.30.

We are offering Pre-Funded Warrants to certain purchasers whose purchase of shares of common stock in this offering would otherwise result in the purchaser, together with its affiliates and certain related parties, beneficially owning more than 4.99% (or, at the election of the purchaser, 9.99%) of our outstanding common stock immediately following the consummation of this offering, the opportunity to purchase, if any such purchaser so chooses, Pre-Funded Warrants, in lieu of shares of common stock. The public offering price of each Pre-Funded Warrant will be equal to the price at which one share of common stock is sold to the public in this offering, minus $0.001, and the exercise price of each Pre-Funded Warrant will be $0.001 per share. The Pre-Funded Warrants will be immediately exercisable and may be exercised at any time until all of the Pre-Funded Warrants are exercised in full. For each Pre-Funded Warrant we sell, the number of shares of common stock we are offering will be decreased on a one-for-one basis.

This prospectus also includes the shares of common stock issuable upon exercise of the Pre-Funded Warrants. See “Description of Securities We Are Offering” in this prospectus for more information.

Our common stock trades on the Nasdaq Capital Market under the symbol “SHPH.” On March 11, 2025, the last reported sale price of our common stock was $0.42 per share.

We have retained WestPark Capital, Inc. as the exclusive underwriter with respect to