Company: BDRX
Filing Date: 2025-01-21
Form Type: 424B3
Source: 0001214659-25-000936
Chunk: 7

Company: Biodexa Pharmaceuticals Plc
Filing Date: 2025-01-21
Form: 424B3
Chunk 7
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Exhibit 10.1

<div align='center'>SECURITIES PURCHASE AGREEMENT</div>

THIS SECURITIES PURCHASE AGREEMENT (the “”), dated as of January 17, 2025 (the “”), by and between
BIODEXA PHARMACEUTICALS PLC, a company incorporated under the laws of England and Wales (the “”), and
C/M CAPITAL MASTER FUND, LP, a Delaware limited partnership (the “”).

<div align='center'>WHEREAS:</div>

Subject to the terms and conditions
set forth in this Agreement, the Company wishes to sell to the Investor, and the Investor wishes to buy from the Company, from time to
time and as provided herein, up to Thirty-Five Million Dollars ($35,000,000) of the Company’s American Depositary Shares (the “”), each representing 10,000 of the Company’s ordinary shares, nominal value £0.00005 each (the “”). The Depositary Shares to be purchased hereunder are referred to herein as the “.”

NOW THEREFORE, in consideration
of the mutual covenants contained in this Agreement, and for other good and valuable consideration, the receipt and adequacy of which
are hereby acknowledged, the Company and the Investor, intending to be legally bound, hereby agree as follows:

1. CERTAIN DEFINITIONS.

For purposes of this Agreement,
the following terms shall have the following meanings:

(a) “” means, with respect to an Additional VWAP Purchase made pursuant to hereof, the Business
Day (i) that is the VWAP Purchase Date with respect to the corresponding VWAP Purchase referred to in clause (i) of the proviso in the
second sentence of hereof and (ii) on which the Investor receives, after 2:00 p.m., Eastern time, but prior to 4:00
p.m., Eastern time, on such Business Day, a valid Additional VWAP Purchase Notice for such Additional VWAP Purchase in accordance with
this Agreement.

(b) “” means, with respect to an Additional VWAP Purchase made pursuant to
hereof, eighty-five percent (85%) of the Closing Sale Price of the Depositary Shares on the Business Day immediately preceding the applicable
Additional VWAP Purchase Date with respect to such Additional VWAP Purchase.

(c) “” means, with respect to an Additional VWAP Purchase made pursuant to hereof, an irrevocable
written notice from the Company to