Company: APM
Filing Date: 2025-10-14
Form Type: 424B5
Source: 0001213900-25-098635
Chunk: 105

Company: Aptorum Group Ltd
Filing Date: 2025-10-14
Form: 424B5
Chunk 105
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 respect to specific matters, including:

| ● | to fix any ambiguity, defect or inconsistency in the indenture; |

| ● | to comply with the provisions described above under “Consolidation, 
 Merger or Sale”;                                                    |

| ● | to comply with any requirements of the SEC in connection with             
 the qualification of any indenture under the Trust Indenture Act of 1939; |

| ● | to evidence and provide for the acceptance of appointment 
 by a successor trustee;                                   |

| ● | to provide for uncertificated debt securities and to make 
 all appropriate changes for such purpose;                 |

| ● | to add to, delete from, or revise the conditions, limitations                                                                          
 and restrictions on the authorized amount, terms or purposes of issuance, authorization and delivery of debt securities or any series, 
 as set forth in the indenture;                                                                                                         |

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| ● | to provide for the issuance of and establish the form and                                                                                
 terms and conditions of the debt securities of any series as provided under “General” to establish the form of any certifications        
 required to be furnished pursuant to the terms of the indenture or any series of debt securities, or to add to the rights of the holders 
 of any series of debt securities;                                                                                                        |

| ● | to add to our covenants such new covenants, restrictions,                                                                                 
 conditions or provisions for the protection of the holders, to make the occurrence, or the occurrence and the continuance, of a default   
 in any such additional covenants, restrictions, conditions or provisions an event of default, or to surrender any of our rights or powers 
 under the indenture; or                                                                                                                   |

| ● | to change anything that does not materially adversely affect  
 the interests of any holder of debt securities of any series. |

In addition, under the indentures,
the rights of holders of a series of debt securities may be changed by us and the debenture trustee with the written consent of the holders
of at least a majority in aggregate principal amount of the outstanding debt securities of each series that is affected. However, we and
the debenture trustee may only make the following changes with the consent of each holder of any outstanding debt securities affected:

| ● | extending the fixed maturity of the series of debt securities; |

| ● | reducing the principal amount, reducing the rate of or extending                                                
 the time of payment of interest, or reducing any premium payable upon the redemption of any debt