Company: LENZ
Filing Date: 2025-04-04
Form Type: S-3
Source: 0001628280-25-016822
Chunk: 2

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-04
Form: S-3
Chunk 2
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 securities, depositary shares, warrants, subscription rights, purchase contracts and/or units representing two or more of the foregoing securities; and

• a prospectus supplement covering the offering, issuance and sale by us of up to a maximum aggregate offering price of $150,000,000 of our Common Stock that may be issued and sold under a sales agreement (“Sales Agreement”) dated April 4, 2025 with TD Securities (USA) LLC (“TD Cowen”).

The base prospectus immediately follows this explanatory note. The Sales Agreement prospectus supplement immediately follows the base prospectus. The $ 150,000,000 of Common Stock that may be offered, issued and sold under the Sales Agreement prospectus supplement is included in the $ 500,000,000 of securities that may be offered, issued and sold by us under the base prospectus. Any portion of the $150,000,000 included in the Sales Agreement prospectus supplement that is not sold pursuant to the Sales Agreement will be available for sale in other offerings pursuant to the base prospectus and a corresponding prospectus supplement, and if no shares are sold under the Sales Agreement, the full $150,000,000 of securities may be sold in other offerings pursuant to the base prospectus and a corresponding prospectus supplement.

The information in this prospectus is not complete and may be changed. The securities may not be sold until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and it is not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.

#### Subject to Completion, dated April 4, 2025

#### PROSPECTUS

#### LENZ Therapeutics, Inc.
<div align='center'>$500,000,000</div>

#### Common Stock

#### Preferred Stock

#### Debt Securities

#### Depositary Shares

#### Warrants

#### Subscription Rights

#### Purchase Contracts

#### Units
We may issue securities from time to time in one or more offerings, in amounts, at prices and on terms determined at the time of offering. This prospectus describes the general terms of these securities and the general manner in which these securities will be offered. We will provide the specific terms of these securities in supplements to this prospectus, which will also describe the specific manner in which these securities will be offered and may also supplement, update or amend information contained in this prospectus. You should read this prospectus and any applicable prospectus supplement before