Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 239

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 239
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| Cash Flow Data:                                          |     |              |         |   |     |              |         |   |     |              |         |   |     |               |         |   |
| Net cash proceeds from operating activities              |     | $            |  19,349 |   |     | $            | (20,707 | ) |     | $            |  21,287 |   |     | $             |  16,815 |   |
| Net cash used for investing activities                   |     |              |  (2,675 | ) |     |              |    (330 | ) |     |              |    (700 | ) |     |               |  (2,480 | ) |
| Net cash used for financing activities                   |     |              | (18,131 | ) |     |              |  25,582 |   |     |              | (22,981 | ) |     |               | (10,948 | ) |
| Net change in cash, cash equivalents and restricted cash |     | $            |  (1,457 | ) |     | $            |   2,545 |   |     | $            |  (2,394 | ) |     | $             |   3,387 |   |

Cash Flows from Operating Activities For the year ended December 31, 2024, net cash proceeds from operating activities was approximately $19.3 million, attributable to non-cashreconciling items of $27.3 million related to allocated expense for financial instruments at fair value, stock-based compensation, change in fair value of debt and liability instruments, allowances for expected credit losses, depreciation and amortization, non-cashoperating lease cost and gain on derivative liabilities, and changes in operating assets and liabilities that provided $64.8 million of cash, partially offset by our net loss of $72.8 million. 158

For the year ended December 31, 2023, net cash used for operating activities was
approximately $20.7 million, attributable to our net loss of $114.3 million, partially offset by other non-cash reconciling items of $27.9 million related to loss on derivative liabilities,
stock-based compensation, change in fair value of debt and liability instruments, depreciation and amortization and non-cash operating lease cost, and changes in operating assets and liabilities that provided
$65.7 million