Company: GANX
Filing Date: 2025-12-03
Form Type: S-8
Source: 0001104659-25-118118
Chunk: 2

Company: Gain Therapeutics, Inc.
Filing Date: 2025-12-03
Form: S-8
Chunk 2
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 therein; provided, however, that
documents or information deemed to have been furnished and not filed in accordance with SEC rules shall not be deemed incorporated
by reference into this Registration Statement. Any statement contained in a document incorporated or deemed to be incorporated by reference
herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained
in any subsequently filed document, which also is deemed to be incorporated by reference herein, modifies or supersedes such statement.

| Item 8. | Exhibits. |

| Exhibit 
 No.     |     | Exhibit Description                                                                                                                 |
| 3.1     |     | Amended                                                                                                                             
 and Restated Certificate of Incorporation of Gain Therapeutics, Inc. (incorporated by reference to Exhibit 3.1 (File No. 001-40237) 
 on Form 8-K filed with the Commission on March 22, 2021).                                                                           |
| 3.2     |     | Certificate                                                                                                                         
 of Amendment of Amended and Restated Certificate of Incorporation of Gain Therapeutics, Inc. filed with the Secretary of State      
 of the State of Delaware on June 24, 2025 (incorporated by reference to Exhibit 3.1 (File No. 001-40237) on Form 8-K                
 filed with the Commission on June 24, 2025).                                                                                        |
| 3.3     |     | Amended                                                                                                                             
 and Restated Bylaws of Gain Therapeutics, Inc. (incorporated by reference to Exhibit 3.2 on Form 8-K (File No. 001-40237)           
 filed with the Commission on March 22, 2021).                                                                                       |
| 5.1*    |     | Opinion                                                                                                                             
 of Lowenstein Sandler LLP.                                                                                                          |
| 10.1    |     | Gain                                                                                                                                
 Therapeutics, Inc. 2022 Equity Incentive Plan (incorporated by reference to Exhibit 4.6 to the Company’s Registration               
 Statement on Form S-8 (File No. 333-266142), filed with the Commission on July 15, 2022).                                           |
| 10.2    |     | Form of                                                                                                                             
 2022 Equity Incentive Plan Restricted Stock Unit Agreement (incorporated by reference to Exhibit 4.8 to the Company’s               
 Registration Statement on Form S-8 (File