Company: TVRD
Filing Date: 2025-11-13
Form Type: 424B3
Source: 0001104659-25-111336
Chunk: 1

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-11-13
Form: 424B3
Chunk 1
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 the section titled “Risk Factors” beginning on page 5 of the Prospectus and under similar headings in any amendments or supplements to the Prospectus.

Neither the Securities Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus supplement is November 13, 2025.</div>

Table of Contents

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

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​

FORM 10-Q

​</div>

(Mark One)

☒QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

<div align='center'>FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2025

OR</div>

☐TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

<div align='center'>COMMISSION FILE NUMBER 001-36279

TVARDI THERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)</div>

| ​                                                     |                  ​ |
| Delaware                                              |         75-3175693 |
| (State or other jurisdiction of                       
 incorporation or organization)                        |   -I.R.S. Employer 
 Identification No. |
| ​                                                     |                  ​ |
| 3 Sugar Creek Ctr. Blvd.                              |                  ​ |
| Suite 525                                             |                  ​ |
| Sugar Land, Texas                                     |              77478 |
| (Address of registrant’s principal executive offices) |          -Zip Code |
| ​                                                     |                  ​ |

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<div align='center'>Registrant’s telephone number, including area code: (713 )489-8654

​</div>

Securities registered pursuant to Section 12(b) of the Act:

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| Title of each class                      | Trading Symbol | Name of each exchange on which registered |
| Common Stock, par value $0.001 per share | TVRD           | The Nasdaq Stock Market LLC               |

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Indicate by check mark whether the registrant (1)
has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months