Company: CNTB
Filing Date: 2025-06-10
Form Type: S-8
Source: 0001193125-25-138485
Chunk: 0

Company: Connect Biopharma Holdings Ltd
Filing Date: 2025-06-10
Form: S-8
Chunk 0
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As filed with the Securities and Exchange Commission on June 10, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Connect Biopharma Holdings Limited (Exact Name of Registrant as Specified in Its Charter)

| Cayman Islands                  |     | Not Applicable     |
| (State or Other Jurisdiction of 
 Incorporation or Organization)  |     | -IRS Employer      
 Identification No. |

3580 Carmel Mountain Road, Suite 200 San Diego, California 92130, USA (Address of Principal Executive Offices and Zip Code) Connect Biopharma Holdings Limited 2021 Stock Incentive Plan Connect Biopharma Holdings Limited 2024 Employment Inducement Incentive Award Plan (Full Title of the Plans) Barry D. Quart, Pharm.D. 3580 Carmel Mountain Road, Suite 200 San Diego, California 92130, USA (Name and Address of Agent for Service) (858) 727-1040 (Telephone Number, including Area Code, of Agent for Service) Copies to: Michael E. Sullivan, Esq. Latham & Watkins LLP 12670 High Bluff Drive San Diego, California 92130 (858) 523-5400 Jeff Cohn, Esq. General Counsel and Corporate Secretary Connect Biopharma Holdings Limited 3580 Carmel Mountain Road, Suite 200 San Diego, California 92130, USA (858) 727-1040 Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-acceleratedfiler, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2of the Exchange Act.

| Large accelerated filer |     | ☐ |     | Accelerated filer         |     | ☐ |
| Non-accelerated filer   |     | ☒ |     | Smaller reporting company |     | ☒ |
|                         |     |   |     | Emerging growth company   |     | ☒ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided