Company: ARWR
Filing Date: 2025-01-29
Form Type: DEF 14A
Source: 0001628280-25-002848
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Company: ARROWHEAD PHARMACEUTICALS, INC.
Filing Date: 2025-01-29
Form: DEF 14A
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Table of Contents

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box:

| ☐ |     | Preliminary Proxy Statement                                                |
| ☐ |     | Confidential, For Use of the Commission Only (as permitted by 14a-6(e)(2)) |
| ☒ |     | Definitive Proxy Statement                                                 |
| ☐ |     | Definitive Additional Materials                                            |
| ☐ |     | Soliciting Material Pursuant To §240.14a-12                                |

ARROWHEAD PHARMACEUTICALS, INC. (Name of Registrant as Specified in Its Charter) (Name of Person(s) Filing Proxy Statement if other than the Registrant) Payment of filing fee (Check all boxes that apply):

| ☒ |     | No fee required.                                                                                     |
| ☐ |     | Fee paid previously with preliminary materials.                                                      |
| ☐ |     | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11. |

#### Table of Contents
Table of Contents Notice of Annual Meeting of Stockholders To Be Held on Wednesday, March 12, 2025

| Your vote is important, whether or not you expect to attend the Annual Meeting of Stockholders. Stockholders of record are urged to vote via the Internet or telephone as instructed, or if you are voting by mail, to mark, sign and date and promptly return the proxy in the postage-prepaid return envelope provided. 
 Voting promptly will help avoid the additional expense of further solicitation to assure a quorum at the meeting.                                                                                                                                                                                                         
 Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to be Held on Thursday, March 12, 2025:                                                                                                                                                                                        
 You may access the following proxy materials atwww.proxyvote.com before the meeting and www.virtualshareholdermeeting.com/ARWR2025 during the meeting.                                                                                                                                                                    
 •Notice of the 2025 Annual Meeting of Stockholders;                                                                                                                                                                                                                                                                       
 •Company’s 2025 Proxy Statement;                                                                                                                                                                                                                                                                                          
 •Company’s Annual Report