Company: PRGO
Filing Date: 2025-05-07
Form Type: S-8
Source: 0001193125-25-115086
Chunk: 1

Company: PERRIGO Co plc
Filing Date: 2025-05-07
Form: S-8
Chunk 1
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 shares, nominal value €0.001 per share (the “ Ordinary Shares”), of Perrigo Company plc (the “ Company” or “ Registrant”) to be offered under the Perrigo Company plc 2019 Long-Term Incentive Plan (the “ 2019 Plan”). The 2019 Plan was adopted as an amendment and restatement of the 2013 Long-Term Incentive Plan (the “ 2013 Plan”), which was adopted as an amendment and restatement of the 2008 Long-Term Incentive Plan (the “ 2008 Plan”), which was adopted as an amendment and restatement of the 2003 Long-Term Incentive Plan (the “ 2003 Plan”). The Company has earlier filed registration statements on Form S-8(File No. 333-277416and 333-270089and 333-261074)relating to the 2019 Plan as well as a Form S-8(File No. 333-192946)relating to the 2013 Plan, the 2008 Plan, the 2003 Plan (the “ Earlier Registration Statements”). Except as modified or superseded herein, the contents of the Earlier Registration Statements are incorporated herein by reference. This Registration Statement is being filed by the Company pursuant to General Instruction E for Form S-8to register the issuance of an additional 1,412,770 Ordinary Shares that have become available for delivery with respect to awards under the 2019 Plan pursuant to the share counting, share recycling and other terms and conditions of the 2019 Plan. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

| Item 8. | Exhibits. |

The following documents are filed or incorporated by reference as part of this Registration Statement.

| Exhibit 
 Number  |     | Description of Exhibit                                                                                                                               |
| 4.1     |     | Certificate of Incorporation of Perrigo Company plc (formerly known as Perrigo Company Limited) (incorporated by reference from Exhibit 4.1 to       
 the Company’s Registration Statement on Form S-8 filed December 19, 2013) (File No. 333-192946).                                                     |
| 4.2     |     | Memorandum and Articles of Association of Perrigo Company plc, as amended and restated (incorporated by reference from Exhibit 3.2                   
 to the Company’s Quarterly Report on Form 10-Q filed on May 7, 2025) (File No