Company: SCLXW
Filing Date: 2025-07-23
Form Type: 424B3
Source: 0001193125-25-163077
Chunk: 4

Company: Scilex Holding Co
Filing Date: 2025-07-23
Form: 424B3
Chunk 4
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 the Securities Act (17 CFR 230.425) |

| ☐ | Soliciting material pursuant to Rule 14a-12 under the Exchange Act 
 (17 CFR 240.14a-12)                                                |

| ☐ | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |

| ☐ | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |

Securities registered pursuant to Section 12(b) of the Act

| Title of each class                                                         |     | Trading   
 Symbol(s) |     | Name of each exchange       
 on which registered         |
| Common stock, par value $0.0001 per share                                   |     | SCLX      |     | The Nasdaq Stock Market LLC |
| Warrants to purchase common stock at an exercise price of $402.50 per share |     | SCLXW     |     | The Nasdaq Stock Market LLC |

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2of the Securities Exchange Act of 1934 (§240.12b-2of this chapter). Emerging growth company ☒ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☒

| Item 1.01. | Entry into a Material Definitive Agreement. |

Equity Line of Credit Common Stock Purchase Agreement On July 22, 2025, Scilex Holding Company (the “ Company”) entered into a Common Stock Purchase Agreement (the “ Purchase Agreement”) with Tumim Stone Capital, LLC, a Delaware limited liability company (the “ Investor”). Pursuant to the Purchase Agreement, the Company has the right, but not the obligation, to sell to the Investor up to the lesser of: (a) $100,000,000 of newly issued shares of the Company’s common stock, par value $0.0001 per share (the “ Common Stock”), and (b) the Exchange Cap (as defined below), from time to time, at the Company’s sole discretion (each