Company: INTS
Filing Date: 2025-04-22
Form Type: S-1
Source: 0001628280-25-018892
Chunk: 6

Company: INTENSITY THERAPEUTICS, INC.
Filing Date: 2025-04-22
Form: S-1
Chunk 6
---
 Warrants and the Pre-Funded Warrants on Nasdaq, any other national securities exchange or any other trading system.

Investing in our securities involves risks. You should review carefully the risks and uncertainties described under the heading “

#### Risk Factors
” contained in this prospectus and under similar headings in the other documents that are incorporated by reference into this prospectus, as described beginning on page

#### 8

#### of this prospectus.
Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the securities to be issued under this prospectus or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

|                                    |     | Per Share of 
 Common Stock 
 and          
 Accompanying 
 Common       
 Warrants     |     | Per Pre-Funded 
 Warrant and    
 Accompanying   
 Common         
 Warrants       |     | Total |
|:-----------------------------------|:----|:-------------|:----|:---------------|:----|:------|
| Public offering price(1)           |     | $            |     | $              |     | $     |
| Placement Agents’ fees(2)          |     | $            |     | $              |     | $     |
| Proceeds to us, before expenses(3) |     | $            |     | $              |     | $     |

__________________

(1) The assumed combined public offering price is $1.88 per share of Common Stock and accompanying Common Warrants and $1.88 per Pre-Funded Warrant and accompanying Common Warrants.

(2) Represents a cash fee equal to seven percent (7.0%) of the aggregate purchase price paid by investors in this offering. See “Plan of Distribution” for additional disclosure regarding compensation payable to the Placement Agents.

(3) Does not include proceeds from the exercise of the Common Warrants and/or Pre-Funded Warrants in cash, if any.

Delivery of the securities is expected to be made on or about , 2025, subject to satisfaction of certain conditions.

<div align='center'>Lead Placement Agent</div>

#### A.G.P.
<div align='center'>Co-Placement Agent</div>

#### Brookline Capital Markets,
<div align='center'>a division of Arcadia Securities, LLC</div>

#### The date of this prospectus is , 2025

### TABLE OF CONTENTS
| ABOUT THIS PROSPECTUS                                    |     | ii |
| SPECIAL NOTE REGARDING