Company: PRME
Filing Date: 2025-04-22
Form Type: DEF 14A
Source: 0001628280-25-018704
Chunk: 2

Company: Prime Medicine, Inc.
Filing Date: 2025-04-22
Form: DEF 14A
Chunk 2
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 the Annual Meeting.

Thank you for your continued support of Prime Medicine, Inc.

By Order of the Board of Directors,

| /s/ Keith Gottesdiener                           |
| Keith Gottesdiener                               |
| President, Chief Executive Officer, and Director |
| April 22, 2025                                   |
| Cambridge, Massachusetts                         |

#### Table of Contents
|                                                                                             |     | Page |
| Proxy Statement for 2025Annual Meeting of Stockholders                                      |     |    1 |
| Important Information About the Annual Meeting and Voting                                   |     |    2 |
| Corporate Governance                                                                        |     |    7 |
| Proposal 1 - Election of Directors                                                          |     |   21 |
| Executive Officers                                                                          |     |   22 |
| Executive Compensation                                                                      |     |   24 |
| Report of the Audit Committee                                                               |     |   34 |
| Certain Relationships and Related Party Transactions                                        |     |   35 |
| Proposal2- Ratification of the Appointment of Independent Registered Public Accounting Firm |     |   38 |
| Security Ownership of Certain Beneficial Owners and Management                              |     |   40 |
| General Matters                                                                             |     |   43 |

#### PRIME MEDICINE, INC.

#### 60 First Street

#### Cambridge, MA 02141
<div align='center'>PROXY STATEMENT FOR 2025 ANNUAL MEETING OF STOCKHOLDERS</div>

#### To Be Held on June 4, 2025
The Board of Directors of Prime Medicine, Inc. (the “Board of Directors,” “Board,” or “our Board”) is soliciting proxies from stockholders for its use at the 2025 annual meeting of our stockholders (the “Annual Meeting”), and at any continuation, postponement, or adjournment of that meeting. The Annual Meeting is scheduled to be held on June 4, 2025, at 2:00 p.m., Eastern Time, in a virtual meeting format, which will be conducted via live webcast at www.virtualshareholdermeeting.com/PRME2025 .

In this proxy statement, “we,” “our,” “us,” the “Company,” and “Prime” refer to Prime Medicine, Inc. and, where appropriate, our subsidiary.

On or about April 22, 2025, we will commence sending the Notice of Internet Availability of Proxy Materials (the “Notice”) to all stockholders of record entitled to notice of, and to vote