Company: SPRB
Filing Date: 2025-10-29
Form Type: S-3
Source: 0001193125-25-256662
Chunk: 43

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-10-29
Form: S-3
Chunk 43
---
ended 2025 Pre-Funded Warrant to Purchase Common Stock.                      | 10-Q | 001-39594                 |     4.2 | August 14, 2025  |
| 4.2     |     | Form of Pre-Funded Warrant to Purchase Common Stock.                                   | 8-K  | 001-39594                 |     4.1 | October 8, 2025  |
| 4.3     |     | Form of Common Stock Certificate.                                                      | S-1  | 333-248924                |     4.1 | October 5, 2020  |
| 4.4

#    |     | Form of Indenture, by and between the Registrant and one or more trustees to be named. |      |                           |         |                  |
| 4.5*    |     | Form of Certificate of Designation of Preferred Stock.                                 |      |                           |         |                  |
| 4.6*    |     | Form of Debt Security.                                                                 |      |                           |         |                  |
| 4.7

#    |     | Form of Common Stock Warrant Agreement and Warrant Certificate.                        |      |                           |         |                  |
| 4.8

#    |     | Form of Preferred Stock Warrant Agreement and Warrant Certificate.                     |      |                           |         |                  |
| 4.9

#    |     | Form of Debt Securities Warrant Agreement and Warrant Certificate.                     |      |                           |         |                  |
| 5.1

#    |     | Opinion of Cooley LLP.                                                                 |      |                           |         |                  |
| 23.1

#   |     | Consent of independent registered public accounting firm.                              |      |                           |         |                  |
| 23.2    |     | Consent of Cooley LLP (included in Exhibit 5.1).                                       |      |                           |         |                  |
| 24.1    |     | Power of Attorney (included on signature page hereto).                                 |      |                           |         |                  |
| 25.1**  |     | Statement of Eligibility of Trustee under the Indenture.                               |      |                           |         |                  |
| 107     |     | Filing Fee Table.                                                                      |      |                           |         |                  |

* To be filed by amendment or