Company: HRTX
Filing Date: 2025-09-19
Form Type: DEF 14A
Source: 0001193125-25-209064
Chunk: 1

Company: HERON THERAPEUTICS, INC. /DE/
Filing Date: 2025-09-19
Form: DEF 14A
Chunk 1
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 Convertible Preferred Stock ”) held by several non-affiliated holders, which could, under certain circumstances that may occur in the future, exceed 19.99% of the number of shares of the Company’s Common Stock issued and outstanding prior to such issuance.

Stockholders will be able to attend the Special Meeting and vote electronically and submit questions during the Special Meeting, all by visitingwww.virtualshareholdermeeting.com/HRTX2025SM .To participate in the Special Meeting, stockholders of record will need the 16-digit control number included on their proxy card. If your shares are held in street name and your voting instruction form indicates that you may vote those shares through thehttp://www.proxyvote.comwebsite, then you may access, participate in, and vote electronically during the Special Meeting with the 16-digit access code indicated on that voting instruction form. Otherwise, stockholders who hold their shares in street name should contact their broker, bank, or other agent (preferably at least five days before the Special Meeting) and obtain a “legal proxy” in order to be able to attend, participate in, or vote at the Special Meeting. The Special Meeting will begin promptly at 9:00 a.m. Eastern Time. We encourage you to access the Special Meeting webcast prior to the start time. Online check-in will begin at 8:45 a.m. Eastern Time, and you should allow ample time for the check-in procedures.

Only stockholders of record at the close of business on September 11, 2025 (the “Record Date”) will be entitled to notice of, and to vote at, the Special Meeting.

BY ORDER OF THE BOARD OF DIRECTORS

/s/ Ira Duarte

Cary, North Carolina

September 19, 2025

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YOUR VOTE IS IMPORTANT</div>

You are cordially invited to attend the Special Meeting. Instructions on how to participate in the Special Meeting and demonstrate proof of stock ownership are included in the accompanying Proxy Statement and posted atwww.virtualshareholdermeeting.com/HRTX2025SM .The webcast of the Special Meeting will be archived for one year after the date of the Special Meeting atwww.virtualshareholdermeeting.com/HRTX2025SM.You will not be able to attend the Special Meeting in person. Whether or not you expect to virtually attend the Special Meeting, you are urged to cast your vote as soon as possible. You may vote your shares via the Internet or via a toll-free telephone number by