Company: CERO
Filing Date: 2025-06-16
Form Type: 424B3
Source: 0001213900-25-054769
Chunk: 6

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-06-16
Form: 424B3
Chunk 6
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 THERAPEUTICS HOLDINGS, INC.

(Exact name of registrant as specified in its charter)</div>

| Delaware                        |     | 001-40877               |     | 81-4182129             |
| (State or other jurisdiction of |     | -Commission File Number |     | (I.R.S. Employer       |
| incorporation or organization)  |     |                         |     | Identification Number) |

| 201 Haskins Way, Suite 230,              |     |           |
| South San Francisco, CA                  |     |     94080 |
| (Address of principal executive offices) |     | -Zip Code |

<div align='center'>(650) 407-2376

Registrant’s telephone number, including area code

Not applicable

(Former name or former address, if changed since last report)</div>

Check the appropriate box below if the Form 8-K filing
is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

| ☐ | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)                  |
| ☐ | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)                 |
| ☐ | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
| ☐ | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR               |

240.13e-4(c)) Securities registered pursuant to Section
12(b) of the Act:

| Title of each class                                                                  |     | Trading Symbol(s) |     | Name of each exchange on which registered |
| Common Stock, par value $0.0001 per share                                            |     | CERO              |     | Nasdaq Capital Market                     |
| Warrants, each warrant exercisable for one two-thousandth of a share of Common Stock |     | CEROW             |     | Nasdaq Capital Market                     |

Indicate by check mark whether the registrant is an
emerging growth company as defined in Rule 405 of the Securities Act of 1933 or Rule 12b-2 of the Securities Exchange Act of 1934.

Emerging growth company ☒

If an emerging growth company, indicate by check mark
if the registrant has