Company: AZN
Filing Date: 2025-06-26
Form Type: 11-K
Source: 0001683168-25-004771
Chunk: 1

Company: ASTRAZENECA PLC
Filing Date: 2025-06-26
Form: 11-K
Chunk 1
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 |       3 |
| Financial Statements:                                          |         |
| Statements of Net Assets Available for Benefits                |       4 |
| Statement of Changes in Net Assets Available for Benefits      |       5 |
| Notes to Financial Statements                                  |       6 |
| Supplemental Schedule:                                         |         |
| Schedule H, line 4i - Schedule of Assets (Held at End of Year) |      16 |
| Signatures                                                     |      18 |
| Index to Exhibit                                               |      19 |

Other supplemental schedules required
by Section 2520.103.10 of the Department of Labor’s Rules and Regulations for Reporting and Disclosure under the Employee Retirement Income
Security Act of 1974 (“ERISA”), as amended, have been omitted because they are not required or are not applicable.

| 2 |

<div align='center'>Report of Independent Registered Public Accounting Firm</div>

To the Administrator and Plan Participants of AstraZeneca Savings and Security Plan

Opinion on the Financial Statements

We have audited the accompanying statements
of net assets available for benefits of AstraZeneca Savings and Security Plan (the “Plan”) as of December 31, 2024 and 2023
and the related statement of changes in net assets available for benefits for the year ended December 31, 2024, including the related
notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly,
in all material respects, the net assets available for benefits of the Plan as of December 31, 2024 and 2023, and the changes in net
assets available for benefits for the year ended December 31, 2024 in conformity with accounting principles generally accepted in the
United States of America.

Basis for Opinion

These financial statements are the responsibility
of the Plan’s management. Our responsibility is to express an opinion on the Plan’s financial statements based on our audits.
We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (PCAOB) and are required
to be independent with respect to the Plan in accordance with the U.S. federal securities laws and the applicable rules and regulations
of the Securities and Exchange Commission and the PCAOB.

We conducted our audits of these financial statements
in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance
about whether the financial statements are free of material misstatement, whether due to