Company: ARWR
Filing Date: 2025-03-07
Form Type: 424B7
Source: 0001193125-25-049889
Chunk: 13

Company: ARROWHEAD PHARMACEUTICALS, INC.
Filing Date: 2025-03-07
Form: 424B7
Chunk 13
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 in this prospectus and any
such prospectus supplement carefully before you invest. This prospectus may not be used to offer or sell any of the common stock, preferred stock, debt securities or warrants unless accompanied by a prospectus supplement.

Our common stock is traded on The Nasdaq Global Select Market (“Nasdaq”) under the symbol “ARWR.” On December 1,
2022, the closing sale price of our common stock on Nasdaq was $32.02 per share. Our principal executive offices are located at 177 E. Colorado Blvd, Suite 700, Pasadena, California 91105, and our telephone number is (626) 304-3400.

Investing in our securities involves a high degree of risk. You should carefully consider the risk and uncertainties referenced under the heading “ Risk Factors” beginning on page 4of this prospectus as well as those contained in the applicable prospectus supplement and any related free writing prospectus, and in the other documents that are incorporated by referenced into this prospectus or any accompanying prospectus supplement.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is December 5, 2022

TABLE OF CONTENTS

| ABOUT THIS PROSPECTUS                             |     |  1 |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |  2 |
| ABOUT THE COMPANY                                 |     |  3 |
| RISK FACTORS                                      |     |  4 |
| USE OF PROCEEDS                                   |     |  5 |
| DESCRIPTION OF SECURITIES                         |     |  6 |
| SELLING STOCKHOLDERS                              |     | 16 |
| PLAN OF DISTRIBUTION                              |     | 17 |
| EXPERTS                                           |     | 20 |
| LEGAL MATTERS                                     |     | 20 |
| WHERE YOU CAN FIND MORE INFORMATION               |     | 21 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE |     | 22 |

ABOUT THIS PROSPECTUS

This prospectus is part of an automatic shelf registration statement that we filed with the Securities and Exchange Commission (the
“SEC”), as a “well-known seasoned issuer” as defined in Rule 405 under the Securities Act of 1933, as amended (the “Securities Act”). Under this shelf registration