Company: TVRD
Filing Date: 2025-01-27
Form Type: S-4/A
Source: 0001104659-25-006050
Chunk: 1015

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-01-27
Form: S-4/A
Chunk 1015
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(d) |

[ Signature pages follow]

A-65

IN WITNESS WHEREOF,the Parties have caused this Agreement to be executed as of the date first above written.

| ​ | CARA THERAPEUTICS, INC.         |                                                |
| ​ | ​                               |                                                |
| ​ | By:                             | /s/ Christopher Posner                         |
| ​ | ​                               | Name: Christopher Posner                       |
| ​ | ​                               | Title:   President and Chief Executive Officer |
| ​ | ​                               | ​                                              |
| ​ | CT CONVERGENCE MERGER SUB, INC. |                                                |
| ​ | ​                               |                                                |
| ​ | By:                             | /s/ Christopher Posner                         |
| ​ | ​                               | Name: Christopher Posner                       |
| ​ | ​                               | Title:   President and Chief Executive Officer |

A-66

IN WITNESS WHEREOF,the Parties have caused this Agreement to be executed as of the date first above written.

| ​ | TVARDI THERAPEUTICS, INC. |                                  |
| ​ | ​                         |                                  |
| ​ | By:                       | /s/ Imran Alibhai, Ph.D.         |
| ​ | ​                         | Name: Imran Alibhai, Ph.D.       |
| ​ | ​                         | Title:   Chief Executive Officer |

A-67

<div align='center'>EXHIBIT A

CERTAIN DEFINITIONS</div>

For purposes of this Agreement (including this Exhibit A):

“Acquisition Inquiry” means, with respect to a Party, an inquiry, indication of interest or request for information (other than an inquiry, indication of interest or request for information made or submitted by the Company or any of its Affiliates, on the one hand, or Parent or any of its Affiliates, on the other hand, to the other Party) that could reasonably be expected to lead to an Acquisition Proposal; provided, however, that the term “Acquisition Inquiry” shall not include the Merger or the other Contemplated Transactions or any transactions related to the Asset Dispositions.

“Acquisition Proposal” means, with respect to a Party, any offer or proposal, whether written or oral (other than an offer or proposal made or submitted by or on behalf of the Company or any of its Affiliates, on the one hand, or by or on behalf of Parent or any of its Affiliates, on the other hand,