Company: NCNA
Filing Date: 2025-05-02
Form Type: F-1/A
Source: 0001193125-25-110310
Chunk: 108

Company: NuCana plc
Filing Date: 2025-05-02
Form: F-1/A
Chunk 108
---
 expenses |     |        | 125,000 |
| Legal fees and expenses         |     |        | 519,000 |
| Accounting fees and expenses    |     |        |  69,000 |
| Miscellaneous costs             |     |        |  12,858 |
| Total                           |     | $      | 750,000 |

All amounts in the table are estimates except the SEC registration fee, the Nasdaq listing fee and the FINRA filing fee. 72

LEGAL MATTERS

We are being represented by Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. with respect to certain legal matters of U.S. federal
securities and New York State law. The validity of our ordinary shares underlying the ADSs and certain matters governed by English law will be passed on for us by Bristows LLP. Legal counsel for the Placement Agent is Sullivan & Worcester
LLP.

EXPERTS

The consolidated financial statements of NuCana plc appearing in NuCana plc’s Annual Report (Form
20-F) for the year ended December 31, 2024 have been audited by Ernst & Young LLP, independent registered public accounting firm, as set forth in their report thereon, included therein, and
incorporated herein by reference. Such consolidated financial statements are incorporated herein by reference in reliance upon such report given on the authority of such firm as experts in accounting and auditing.

The registered business address of Ernst & Young LLP is 144 Morrison Street, Edinburgh, EH3 8EX, United Kingdom.

ENFORCEMENT OF CIVIL LIABILITIES

We are a public limited company incorporated under the laws of England and Wales. Certain of our directors and executive officers and experts
named in this prospectus reside outside of the United States, and all or a substantial portion of our assets and the assets of such persons are located outside the United States. As a result, it may be difficult for an investor to serve process on
us or our directors and executive officers or to compel any of them to appear in Court in the United States or to enforce judgments obtained in U.S. courts against them or us, including judgments based on civil liability provisions of the securities
laws of the United States. In addition, awards of punitive damages in actions brought in the United States or elsewhere may be unenforceable in the United Kingdom. An award for monetary damages under the U.S. securities laws would be considered
punitive in the United Kingdom