Company: TEM
Filing Date: 2025-02-25
Form Type: S-1
Source: 0001193125-25-034442
Chunk: 77

Company: Tempus AI, Inc.
Filing Date: 2025-02-25
Form: S-1
Chunk 77
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 undersigned registrant relating to the offering required to 
 be filed pursuant to Rule 424;                                                                              |

| (ii) | Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant 
 or used or referred to by the undersigned registrant;                                                       |

| (iii) | The portion of any other free writing prospectus relating to the offering containing material information      
 about the undersigned registrant or our securities provided by or on behalf of the undersigned registrant; and |

| (iv) | Any other communication that is an offer in the offering made by the undersigned registrant to the 
 purchaser.                                                                                         |

| (b) | Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to                                                                                                                                                 
 directors, officers and controlling persons of the undersigned pursuant to the foregoing provisions, or otherwise, the undersigned has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the    
 Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the undersigned of expenses incurred or paid by a director, officer or controlling person of the     
 undersigned in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the undersigned will, unless in the opinion of our counsel the 
 matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such 
 issue.                                                                                                                                                                                                                                                  |

II-8

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized in Chicago, Illinois, on this 25 thday of February, 2025.

| TEMPUS AI, INC. |     |                                               |
| By:             |     | /s/ Eric Lefkofsky                            |
|                 |     | Eric Lefkofsky                                
 Chief Executive Officer, Founder and Chairman |

KNOW ALL BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Eric Lefkofsky, James Rogers and Andrew Polovin, and each of them, as his or