Company: VRCA
Filing Date: 2025-12-23
Form Type: 424B3
Source: 0001193125-25-330986
Chunk: 1

Company: Verrica Pharmaceuticals Inc.
Filing Date: 2025-12-23
Form: 424B3
Chunk 1
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 if any Common Warrants are exercised for cash, the exercise price of $6.315 per share.

The selling stockholders may offer and sell or otherwise dispose of the Resale Shares described in this prospectus from time to time through
public or private transactions at prevailing market prices, at prices related to prevailing market prices or at privately negotiated prices. The selling stockholders will bear all underwriting fees, commissions and discounts, if any, attributable to
the sales of Resale Shares and any transfer taxes. We will bear all other costs, expenses and fees in connection with the registration of the Resale Shares. See “Plan of Distribution” for more information about how the selling
stockholders may sell or dispose of their Resale Shares and Warrant Shares.

Our common stock is listed on The Nasdaq Capital Market under
the trading symbol “VRCA.” On December 22, 2025, the closing price of our common stock was $7.91 per share.

Investing in our common stock involves a high degree of risk. Before making an investment decision, please read the information under “ Risk Factors” on page 4 of this prospectus and under similar headings in any amendment or supplement to this prospectus or in any filing with the Securities and Exchange Commission that is incorporated by reference herein.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is December 23, 2025.

TABLE OF CONTENTS

|                                                   |     | Page |    |
| ABOUT THIS PROSPECTUS                             |     |      | ii |
| PROSPECTUS SUMMARY                                |     |      |  1 |
| RISK FACTORS                                      |     |      |  4 |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |      |  5 |
| USE OF PROCEEDS                                   |     |      |  6 |
| SELLING STOCKHOLDERS                              |     |      |  7 |
| PLAN OF DISTRIBUTION                              |     |      | 12 |
| LEGAL MATTERS                                     |     |      | 15 |
| EXPERTS                                           |     |      | 15 |
| WHERE YOU CAN FIND ADDITIONAL INFORMATION         |     |      | 15 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE |     |      | 15 |

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