Company: TAK
Filing Date: 2025-06-26
Form Type: 424B5
Source: 0001395064-25-000101
Chunk: 19

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-26
Form: 424B5
Chunk 19
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 fully registered form without interest coupons in denominations of $200,000 and integral multiples of $1,000 in excess thereof. The Notes will be represented by one or more registered notes in global form without coupons and in certain circumstances may be represented by notes in definitive form.

The TUSFI Indenture (including the Guarantee) and the Notes do not contain any financial covenants or restrictions on the payment of dividends, the incurrence of indebtedness, including other senior indebtedness (other than as set forth under “Description of Senior Debt Securities and Guarantee—Negative Pledge” in the accompanying prospectus), or the issuance or repurchase of the Issuer’s securities. The TUSFI Indenture and the Notes do not contain any covenants or other provisions to afford protection to holders of the Notes in the event of a highly leveraged transaction or a change in control of the Issuer or the Guarantor.

The terms of the Notes and the Guarantee include those stated in the TUSFI Indenture and those made part of the TUSFI Indenture by reference to the Trust Indenture Act of 1939, as amended (the “Trust Indenture Act”). The Notes and the Guarantee are subject to all such terms, and holders of Notes should refer to the TUSFI Indenture and the Trust Indenture Act for a statement thereof.

#### Status of the Notes
The Notes will be the Issuer’s direct, unsecured and unsubordinated general obligations and will have the same rank in liquidation as all of the Issuer’s other unsecured and unsubordinated debt.

#### Principal and Maturity
The initial aggregate principal amount of the Notes is as follows:

• For the 2035 Notes, $ ; and

• For the 2055 Notes, $

The Notes will mature on the following dates:

• For the 2035 Notes, ●, 20 ; and

<div align='center'>S-14</div>

• For the 2055 Notes, ●, 20 .

Principal will be repaid at maturity at a price of 100% of the principal amount of the Notes. The Notes will not be redeemable prior to maturity, except as set forth below under “—Redemption,” and will not be subject to any sinking fund.

#### Interest
Interest on the Notes will accrue at the following rates:

• For the 2035 Notes: % per annum; and

• For the 2055 Notes: % per annum.

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