Company: NCNA
Filing Date: 2025-06-18
Form Type: F-3/A
Source: 0001193125-25-142565
Chunk: 59

Company: NuCana plc
Filing Date: 2025-06-18
Form: F-3/A
Chunk 59
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 Soliciting Material The depositary will make available for your inspection at its office all communications that it receives from us as a holder of deposited securities that we make generally available to holders of deposited securities. Subject to the terms of the deposit agreement, the depositary will send you copies of those communications or otherwise make those communications available to you if we ask it to. Limitations on Obligations and Liabilities The deposit agreement limits our obligations and the depositary’s obligations to you. Please note the following:

| • |     | We and the depositary are obligated only to take the actions specifically stated in the deposit agreement without 
 negligence or bad faith.                                                                                          |

| • |     | The depositary disclaims any liability for any failure to carry out voting instructions, for any manner in which                        
 a vote is cast or for the effect of any vote, provided it acts in good faith and in accordance with the terms of the deposit agreement. |

| • |     | The depositary disclaims any liability for any failure to accurately determine the lawfulness or practicality of 
 any action, for the content of any document forwarded to you on our behalf or for the                            |

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| accuracy of any translation of such a document, for the investment risks associated with investing in ordinary shares, for the validity or worth of the ordinary shares, for any tax consequences                                                        
 that result from the ownership of ADSs or other deposited property, for the credit-worthiness of any third party, for allowing any rights to lapse under the terms of the deposit agreement, for the timeliness of any of our notices or for our failure 
 to give notice or for any act or omission of or information provided by DTC or any DTC participant.                                                                                                                                                      |

| • |     | The depositary shall not be liable for acts or omissions of any successor depositary in connection with any 
 matter arising wholly after the resignation or removal of the depositary.                                   |

| • |     | We and the depositary will not be obligated to perform any act that is inconsistent with the terms of the deposit 
 agreement.                                                                                                        |

| • |     | We and the depositary disclaim any liability if we or the depositary are prevented or forbidden from or subject                                                                                                                                           
 to any civil or criminal penalty or restraint on account of, or delayed in, doing or performing any act or thing required by the terms of the deposit agreement, by reason of any provision, present or future of any law or regulation, including        
 regulations of any stock exchange