Company: PSTV
Filing Date: 2025-08-04
Form Type: DRS
Source: 0000950123-25-006916
Chunk: 20

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-08-04
Form: DRS
Chunk 20
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 or                                                                                                                                          
 market price thresholds specified in the Purchase Agreement are crossed on the applicable Accelerated Purchase date, which is defined as the next business day following the purchase date for the corresponding Regular Purchase, the portion of the 
 normal trading hours on the applicable Accelerated Purchase date prior to such time that any one of such thresholds is crossed, which period of time on the applicable Accelerated Purchase date we refer to as the Accelerated Purchase Measurement  
 Period; and                                                                                                                                                                                                                                           |

| • |     | 300% of the number of purchase shares purchased pursuant to the corresponding Regular Purchase. |

The purchase price per share for each such Accelerated Purchase will be equal to 96.5% of the lower of:

| • |     | the volume weighted average price of our common stock during the Accelerated Purchase Measurement Period on the 
 applicable Accelerated Purchase date; and                                                                       |

| • |     | the closing sale price of our common stock on the applicable Accelerated Purchase date. |

We may also direct Lincoln Park, not later than 1:00 p.m., Eastern time, on a business day on which an Accelerated Purchase has been completed and all of the shares of our common stock to be purchased thereunder (and under the corresponding Regular Purchase) have been properly delivered to Lincoln Park in accordance with the Purchase Agreement prior to such time on such business day, to purchase an additional amount of our common stock, which we refer to as an Additional Accelerated Purchase, of up to the lesser of:

| • |     | 30% of the aggregate number of shares of our common stock traded during a certain portion of the normal trading                                                                                  
 hours on such Accelerated Purchase date as determined in accordance with the Purchase Agreement, which period of time we refer to as the Additional Accelerated Purchase Measurement Period; and |

| • |     | 300% of the number of purchase shares purchased pursuant to the Regular Purchase corresponding to the Accelerated                       
 Purchase that was completed on such Accelerated Purchase date on which an Additional Accelerated Purchase notice was properly received. |

We may, in our sole discretion, submit multiple Additional Accelerated Purchase notices to Lincoln Park prior to 1:00 p.m., Eastern time, on a single Accelerated Purchase date, provided that all prior Accelerated Purchases and Additional Accelerated Purchases (including those that have occurred earlier on the same day) have been completed and all of the shares of our common stock to be purchased thereunder (and under the corresponding Regular Purchase) have been properly delivered to Lincoln Park in