Company: PSTV
Filing Date: 2025-08-22
Form Type: S-8
Source: 0001193125-25-186490
Chunk: 1

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-08-22
Form: S-8
Chunk 1
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Registration Statement”) registers an aggregate of 20,075,000 additional shares of common stock, par value $0.001 per share (the “Common Stock”) of Plus Therapeutics, Inc. (the “Registrant”), consisting of (i) 20,000,000 shares of Common Stock issuable pursuant to the Fifth Amended and Restated Plus Therapeutics, Inc. 2020 Stock Incentive Plan (the “2020 Stock Incentive Plan”), representing an increase of 20,000,000 shares of Common Stock reserved for issuance under the 2020 Stock Incentive Plan, as a result of an amendment thereto, which was adopted by the board of directors (the “Board”) of the Registrant on July 17, 2025 and approved by the Registrant’s stockholders at the Annual Meeting of Stockholders held on August 7, 2025; and (ii) 75,000 shares of Common Stock issuable pursuant to the Plus Therapeutics, Inc. 2015 New Employee Incentive Plan (as amended, the “2015 Plan”), representing an increase of 75,000 shares of Common Stock reserved for issuance under the 2015 Plan, as a result of an amendment thereto, which was adopted by the Board on June 6, 2024. Pursuant to General Instruction E to Form S-8under the Securities Act of 1933, as amended, the contents of the Registrant’s registration statements on Form S-8filed with the U.S. Securities and Exchange Commission (the “Commission”) on March 15, 2016 (Registration No. 333-210211),March 9, 2018 (Registration No. 333-223566),June 30, 2020 (Registration No. 333-239548)and on August 23, 2024 (Registration No. 333-281758) are incorporated by reference and made part of this Registration Statement. Any items in such registration statements not expressly changed hereby shall be as set forth in such registration statements. PART II INFORMATION REQUIRED IN THE REGISTRATION STATEMENT Item 3. Incorporation of Documents by Reference. The following documents filed by Registrant with the Commission are hereby incorporated by reference in this Registration Statement:

| (b) | all other reports filed by the Registrant pursuant to Section 13(a) or 15(d) of the Securities Exchange                                                                                     
 Act of 1934 (the “Exchange Act”)