Company: RNLXY
Filing Date: 2025-07-25
Form Type: S-8 POS
Source: 0001213900-25-067774
Chunk: 1

Company: Renalytix plc
Filing Date: 2025-07-25
Form: S-8 POS
Chunk 1
---
 Registration Statement shall become effective upon filing in accordance with Rule 464 promulgated under the Securities Act of 1933, as amended.

<div align='center'>DEREGISTRATION OF SHARES</div>

Renalytix plc (the “Company”)
is filing this Post-Effective Amendment No. 1 to the Registration Statement on Form S-8 (File No. 333-274732) (the “Registration
Statement”), to deregister the offer of the ordinary shares, nominal value £0.0025 per ordinary share, of the Company, registered
under the Registration Statement that remain unissued under each of the Renalytix AI plc 2020 Employee Share Purchase Plan, and Renalytix
AI plc 2020 Equity Incentive Plan.

The Registration Statement is hereby amended,
as appropriate, to reflect the deregistration of such securities and the Company hereby terminates the effectiveness of the Registration
Statement.

<div align='center'>1

SIGNATURES</div>

The Registrant. Pursuant to the requirements
of the Securities Exchange Act of 1933, as amended, the Registrant certifies that is has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned,
thereunto duly authorized, in the City of London, United Kingdom, on July 25, 2025.

| RENALYTIX PLC        |                                      |
| /s/ James McCullough |                                      |
| Name:                | James McCullough                     |
| Title:               | Chief Executive Officer and Director |

No other person is required to sign this Post-Effective Amendment to the Registration Statement in reliance on Rule 478 of the Securities
Act of 1933, as amended.

<div align='center'>2</div>