Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 10

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 10
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 listing for 
 the Pre-Funded Warrants on any securities exchange or other nationally recognized trading system. Without an active trading market, the liquidity of the Pre-Funded                                                                                                                                                                  
 Warrants will be limited.                                                                                                                                                                                                                                                                                                            |

| To better understand the terms of the Pre-Funded Warrants, you should carefully read the “Description of Securities We Are Offering” section of this prospectus. |

| Series A Warrants offered by us | Each ADS and each Pre-Funded Warrant to purchase one ADS is being sold together with a Series A Warrant to purchase one ADS. Each Series A Warrant will have an exercise price of $   per ADS, 
 will be exercisable at any time beginning on the Initial Exercise Date and will expire on the five-year anniversary of the Initial Exercise Date.                                              |

| This prospectus also relates to the offering of the ADSs issuable upon exercise of the Series A Warrants. Because we will issue a Series A Warrant for each ADS and for each 
 Pre-Funded Warrant sold in this offering, the number of Series A Warrants sold in this offering will not change as a result of a change in the mix of the ADSs and           
 Pre-Funded Warrants sold.                                                                                                                                                    |

| To better understand the terms of the Series A Warrants, you should carefully read the “Description of Securities We Are Offering” section of this prospectus. |

4

Confidential Treatment Requested by Nucana plc Pursuant to 17 C.F.R. Section 200.83

| Series B Warrants offered by us | Each ADS and each Pre-Funded Warrant to purchase one ADS is being sold together with a Series B Warrant to purchase one ADS. Each Series B Warrant will have an exercise price of $   per ADS, 
 will be exercisable at any time beginning on the Initial Exercise Date and will expire on the two and one-half (2.5)-year anniversary of the Initial Exercise Date.                            |

| This prospectus also relates to the offering of the ADSs issuable upon exercise of the Series B Warrants. Because we will issue a Series B Warrant for each ADS and for each 
 Pre-Funded Warrant sold in this offering, the number of Series B Warrants sold in this offering will not change as a result of a change in the mix of the ADSs and           
 Pre-Funded Warrants sold.                                                                                                                                                    |

| To better understand the terms of the Series B Warrants, you