Company: APM
Filing Date: 2025-10-14
Form Type: 424B5
Source: 0001213900-25-098635
Chunk: 77

Company: Aptorum Group Ltd
Filing Date: 2025-10-14
Form: 424B5
Chunk 77
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 to or through underwriters or dealers. For additional information
on the methods of sale, you should refer to the section entitled “Plan of Distribution” in this prospectus. If any underwriters
are involved in the sale of any securities with respect to which this prospectus is being delivered, the names of such underwriters and
any applicable commissions or discounts will be set forth in a prospectus supplement. The price to the public of such securities and the
net proceeds we expect to receive from such sale will also be set forth in a prospectus supplement.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is December 19, 2022.

TABLE OF CONTENTS</div>

|                                                | Page |
| About this Prospectus                          |   ii |
| Commonly Used Defined Terms                    |  iii |
| Note Regarding Forward-Looking Statements      |  vii |
| Our Business                                   |    1 |
| Risk Factors                                   |    4 |
| Use Of Proceeds                                |    5 |
| Dilution                                       |    6 |
| Description of Share Capital                   |    7 |
| Description of Warrants                        |   13 |
| Description of Units                           |   16 |
| Description of Debt Securities                 |   17 |
| Plan of Distribution                           |   25 |
| Selling Shareholders                           |   27 |
| Selling Shareholder Plan of Distribution       |   29 |
| Legal Matters                                  |   31 |
| Experts                                        |   31 |
| Financial Information                          |   31 |
| Information Incorporated By Reference          |   31 |
| Where You Can Find More Information            |   32 |
| Enforceability of Civil Liabilities            |   33 |
| Indemnification For Securities Act Liabilities |   33 |

<div align='center'>i

ABOUT THIS PROSPECTUS</div>

This prospectus is part of
a registration statement that we filed with the Securities and Exchange Commission, or the SEC, under the Securities Act of 1933, as amended,
or the Securities Act, using a “shelf” registration process. Under this shelf registration process, we may from time to time
sell Class A Ordinary Shares, preferred shares, warrants to purchase Class A Ordinary Shares or preferred shares, debt