Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 50

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 50
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 issue the depositary shares. Listing the depositary shares on the NYSE does not guarantee that a trading market will develop or, if a trading market does develop, the depth of that market or the ability of
holders to sell their depositary shares easily. We do not expect that there will be any separate public trading market for the shares of the Series B Preferred Stock except as represented by the depositary shares.

S-33

Form of Depositary Shares

The depositary shares will be issued in book-entry form through DTC, as described in “Book-Entry Issuance.” The Series B Preferred
Stock will be issued in registered form to the depositary as described in “Description of the Series B Preferred Stock.”

Miscellaneous

Upon our written instruction, the depositary will forward to holders of our depositary receipts any reports and communications from us
that are received by the depositary with respect to the Series B Preferred Stock.

Neither we nor the depositary will be liable if we are
prevented from or delayed in, by law or any circumstances beyond our control, performing our obligations under the deposit agreement. The depositary will not be subject to liability under the deposit agreement other than for its gross negligence,
willful misconduct or bad faith and will not be liable for special, punitive, incidental, indirect or consequential losses or damages. The depositary will not be obligated to, but may, prosecute or defend any legal proceeding in respect of any
depositary receipts, depositary shares or the Series B Preferred Stock represented by the depositary shares subject to the provision of indemnity satisfactory to the depositary. The depositary may rely on written advice of counsel or accountants, or
information provided by persons presenting Series B Preferred Stock represented by the depositary shares for deposit, holders of depositary receipts or other persons, satisfactory to the depositary, to give such information, and on documents
believed to be genuine and signed by a proper party.

S-34

BOOK-ENTRY ISSUANCE

DTC will act as securities depositary for all of the depositary shares. We will issue the depositary shares only as fully-registered
securities registered in the name of Cede & Co. (DTC’s nominee). We will issue and deposit with DTC one or more fully-registered global certificates for the depositary shares representing, in the aggregate, the total number of the
depositary shares to be sold in this offering.

DTC has advised us that it is a limited purpose trust company organized