Company: DNLI
Filing Date: 2025-04-17
Form Type: DEF 14A
Source: 0001714899-25-000087
Chunk: 51

Company: Denali Therapeutics Inc.
Filing Date: 2025-04-17
Form: DEF 14A
Chunk 51
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 | $                 | 337,416 |
| Carole Ho, M.D.           |     | $                | 536,000 |     |                                 | 45 | % |     |                    | 140 | % |     | $                 | 337,416 |

Long-Term Incentives

In 2024 we granted our executives’ target equity compensation in the form of time-vesting RSUs and stock options. In determining the awards vehicles, the compensation committee considers the appropriate split of such equity awards, including the balancing of incentives and retention needs, stockholder dilution and equity plan share reserve management.

Equity granted to our executives in 2024 are detailed below and in the section "Grants of Plan-Based Awards":

| Executive                 |     | RSUs |     | Number Granted |        |     | Grant Date Fair Value |           |     | Options        
 Number Granted |         |     | Grant Date Fair Value |           |
|:--------------------------|:----|:-----|:----|:---------------|-------:|:----|:----------------------|----------:|:----|:---------------|--------:|:----|:----------------------|----------:|
| Ryan J. Watts, Ph.D.      |     |      |     |                | 89,520 |     | $                     | 1,819,942 |     |                | 268,560 |     | $                     | 3,405,851 |
| Alexander O. Schuth, M.D. |     |      |     |                | 53,720 |     | $                     | 1,092,128 |     |                | 161,160 |     | $                     | 2,043,815 |
| Carole Ho, M.D.           |     |      |     |                | 53,720 |     | $                     | 1,092,128 |     |                | 161,160 |     | $                     | 2,043,815 |

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#### Severance and Change in Control Protections
We maintain a Key Executive Change in Control and Severance Plan (the “Severance Plan”) in which our NEOs participate. The Severance Plan provides participants with severance in the event of certain qualifying terminations, including following a change in control of our Company, and certain change in control benefits. We believe that these protections are necessary to provide our valuable executives with incentives to