Company: SMNR
Filing Date: 2025-08-12
Form Type: S-4/A
Source: 0001193125-25-178821
Chunk: 1089

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-08-12
Form: S-4/A
Chunk 1089
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 to the requirements of the Securities Act, the co-registranthas duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, on the 12th day of August, 2025.

| Semnur Pharmaceuticals, Inc. |     |                                              |
| By:                          |     | /s/ Jaisim Shah                              |
|                              |     | Name: Jaisim Shah                            |
|                              |     | Title: Chief Executive Officer and President |

POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Henry Ji, Ph.D. and Jaisim Shah, and each of them acting individually, as his or her true and lawful attorneys-in-factand agents, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments to this Registration Statement on Form S-4,and to file the same, with all exhibits thereto, and other documents in connection therewith, with the United States Securities and Exchange Commission, granting unto said attorney-in-factand agent, full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorney-in-factand agent, or his substitutes or substitute, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

| Signature                           
 /s/ Jaisim Shah Jaisim Shah         
 /s/ Henry Ji, Ph.D. Henry Ji, Ph.D. |     | Title                                 
 Chief Executive Officer and President 
 (Principal Executive Officer)         
 Treasurer, Secretary and Director     |     | Date            
 August 12, 2025 
 August 12, 2025 |
|:------------------------------------|:----|:--------------------------------------|:----|:----------------|
| /s/ Stephen Ma Stephen Ma           |     | Principal Financial Officer           |     | August 12, 2025 |

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