Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 162

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 162
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 for an aggregate of 1,356,594 shares of Common Stock. On the same date, we also issued
to StockBlock, Rodman & Renshaw LLC, or their respective designees the November 2025 Placement Agent Warrants to purchase up to an aggregate of 72,352 shares of Common Stock, which are currently exercisable for an aggregate of 72,352 shares
of Common Stock. The exercise price of both the November 2025 Investor Warrant and the November 2025 Placement Agent Warrants is $29.00 per share.

To the extent the SPAC Warrants, the Penny Warrants, the February 2024 BDO Firm Warrants, the February 2024 BDO Representative Warrants, the
Deposit Warrant, the Fee Warrant, the April 2024 RDO Common Warrants, the April 2024 RDO Placement Agent Warrants, the October 2024 Noteholder Warrants, the October 2024 Placement Agent Warrants, the December 2024 RDO Common Warrants, the StockBlock
Warrants, the Exchange Warrants, the September 2025 Warrants, the November 2025 Investor Warrant, and the November 2025 Placement Agent Warrants (collectively, the “Warrants”) are exercised, additional shares of our Common Stock will be
issued, which will result in dilution to the holders of our Common Stock and increase the number of shares eligible for resale in the public market. Sales of substantial numbers of such shares in the public market, or the fact that such Warrants may
be exercised, could adversely affect the prevailing market prices of our Common Stock. There is no guarantee that the Warrants will ever be in the money prior to their expiration, and as such, the Warrants may expire worthless. See below risk
factor, “The SPAC Warrants may never be in the money, they may expire worthless and the terms of the SPAC Warrants may be amended in a manner adverse to a holder if holders of a majority of the then-outstanding SPAC Warrants approve of such amendment. In addition, almost all of the other warrants to purchase shares of our Common Stock are out-of-the-moneyand may also expire worthless.”

100

The SPAC Warrants may never be in the money, they may expire worthless and the terms of the SPAC Warrants may be amended in a manner adverse to a holder if holders of a majority of the then-outstanding SPAC Warrants