Company: NCNA
Filing Date: 2025-06-18
Form Type: F-3/A
Source: 0001193125-25-142565
Chunk: 35

Company: NuCana plc
Filing Date: 2025-06-18
Form: F-3/A
Chunk 35
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 of any series of subordinated debt; |

| • |     | the place or places where payments will be payable; |

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| • |     | our right, if any, to defer payment of interest and the maximum length of any such deferral period; |

| • |     | the date, if any, after which, and the price at which, we may, at our option, redeem the series of debt 
 securities pursuant to any optional redemption provisions;                                              |

| • |     | the date, if any, on which, and the price at which we are obligated, pursuant to any mandatory sinking fund 
 provisions or otherwise, to redeem, or at the holder’s option to purchase, the series of debt securities;   |

| • |     | whether the indenture will restrict our ability to pay dividends, or will require us to maintain any asset ratios 
 or reserves;                                                                                                      |

| • |     | whether we will be restricted from incurring any additional indebtedness; |

| • |     | a discussion of any material or special U.S. federal income tax considerations applicable to a series of debt 
 securities;                                                                                                   |

| • |     | the denominations in which we will issue the series of debt securities, if other than denominations of $1,000 and 
 any integral multiple thereof; and                                                                                |

| • |     | any other specific terms, preferences, rights or limitations of, or restrictions on, the debt securities. We may                                                                                                                                      
 issue debt securities that provide for an amount less than their stated principal amount to be due and payable upon declaration of acceleration of their maturity pursuant to the terms of the indenture. We will provide you with information on the 
 federal income tax considerations and other special considerations applicable to any of these debt securities in the applicable prospectus supplement.                                                                                                |

C onversion or Exchange Rights We will set forth in the prospectus supplement the terms, if any, on which a series of debt securities may be convertible into or exchangeable for our ordinary shares or our other securities. We will include provisions as to whether conversion or exchange is mandatory, at the option of the holder or at our option. We may include provisions pursuant to which the number of ordinary shares or our other securities that the holders of the series of debt securities receive would be subject to adjustment. Consolidation, Merger or Sale; No Protection in Event of a Change of Control or Highly Leveraged Transaction The indentures do not contain any covenant that restricts our ability to merge or consolidate, or