Company: NCNA
Filing Date: 2025-04-24
Form Type: F-1
Source: 0001193125-25-092131
Chunk: 8

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-1
Chunk 8
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ATION                                          |     | 55 |
| PLAN OF DISTRIBUTION                              |     | 68 |
| EXPENSES                                          |     | 71 |
| LEGAL MATTERS                                     |     | 72 |
| EXPERTS                                           |     | 72 |
| ENFORCEMENT OF CIVIL LIABILITIES                  |     | 72 |
| WHERE YOU CAN FIND MORE INFORMATION               |     | 72 |
| INCORPORATION OF DOCUMENTS BY REFERENCE           |     | 73 |

No action is being taken in any jurisdiction outside the United States to permit a public offering of the ADSs or possession or distribution of this prospectus in that jurisdiction. Persons who come into possession of this prospectus in jurisdictions outside the United States are required to inform themselves about and to observe any restrictions as to this offering and the distribution of the prospectus applicable to that jurisdiction. We are incorporated under the laws of England and Wales and a majority of our outstanding securities are owned by non-U.S.residents. Under the rules of the SEC, we are currently eligible for treatment as a “foreign private issuer.” As a foreign private issuer, we will not be required to file periodic reports and financial statements with the SEC as frequently or as promptly as domestic registrants whose securities are registered under the Securities Exchange Act of 1934, as amended, or the Exchange Act. i

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement that we have filed with the SEC. You should rely only on the information contained in this
prospectus or incorporated by reference in this prospectus or any related prospectus supplement. We have not authorized anyone to provide you with different information. If anyone provides you with different or inconsistent information, you should
not rely on it. The information contained in this prospectus is accurate only on the date of this prospectus. Our business, financial condition, results of operations and prospects may have changed since such date. Other than as required under the
federal securities laws, we undertake no obligation to publicly update or revise such information, whether as a result of new information, future events or any other reason. This prospectus contains summaries of certain provisions contained in some
of the documents described herein, but reference is made to the actual documents for complete information. All of the summaries are qualified in their entirety by the actual documents. Copies of some of the documents referred to herein have been
filed, will be filed, or will be or have been incorporated by reference as exhibits to