Company: SMNR
Filing Date: 2025-12-03
Form Type: S-8
Source: 0001193125-25-306962
Chunk: 4

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-12-03
Form: S-8
Chunk 4
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 resold under this
Reoffer Prospectus by each Selling Stockholder or other person with whom he or she is acting in concert for the purpose of selling shares of Common Stock, may not exceed, during any three-month period, the amount specified in Rule 144(e) under
the Securities Act.

Our Common Stock trades on the Pink Limited Market of the OTC Markets Group, Inc. under the symbol
“SMNR”. On December 2, 2025, the last reported sales price per share of our Common Stock was $9.00.

We are an
“emerging growth company” and a “smaller reporting company” as defined under the U.S. federal securities laws and, as such, we have elected to comply with certain reduced public company reporting requirements for this Reoffer
Prospectus and future filings with the Securities and Exchange Commission (the “Commission”).

We may amend or supplement this Reoffer Prospectus from time to time by filing amendments or
supplements as required. You should read this Reoffer Prospectus, together with additional information described under the heading “Where You Can Find More Information”, and any amendments or supplements carefully before you
invest in any of our securities.

Investing in our Common Stock involves substantial risk. You should review carefully the risks and uncertainties described under the heading “Risk Factors” beginning on page 7 of this Reoffer Prospectus.

Neither the Commission nor any other regulatory body has approved or disapproved of these securities or passed upon the accuracy or adequacy of this Reoffer Prospectus. Any representation to the contrary is a criminal offense.

The date of this Reoffer Prospectus is December 3, 2025.

TABLE OF CONTENTS Page

| About This Reoffer Prospectus                        |     |  1 |
| Where You Can Find More Information                  |     |  1 |
| Incorporation of Certain Information by Reference    |     |  1 |
| Cautionary Note Regarding Forward-Looking Statements |     |  3 |
| Summary of this Reoffer Prospectus                   |     |  5 |
| Risk Factors                                         |     |  7 |
| Determination of Offering Price                      |     |  7 |
| Use of Proceeds                                      |     |  7 |
| Description of Securities                            |     |  7 |
| Selling Stockholders                                 |     |  8 |
| Plan of Distribution                                 |     | 12 |
| Legal Matters                                        |     | 15 |
|