Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 102

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 102
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ification arrangements permitted by our articles of association, and intend to enter into indemnity agreements with any new directors and executive officers in the future. These indemnity agreements may require us, subject to the provisions of any relevant legislation, to indemnify our directors and such officers against all costs, charges, losses, expenses and liabilities incurred by such director or officer for negligence, default, breach of duty, breach of trust or otherwise in respect of such individual’s acts or omissions while in the course of acting or purporting to act as our director or officer or which otherwise arises by virtue of such director or officer holding or having held such a position. We have also purchased and maintain directors’ and officers’ liability insurance to insure, for the period of their appointment, each of its directors and officers in respect of their appointments as our directors or officers. Under the Companies Act 2006, any provision (whether contained in a company’s articles of association or any contract or otherwise) that purports to exempt a director of a company, to any extent, from any liability that would otherwise attach to him in connection with any negligence, default, breach of duty or breach of trust in relation to the company is void. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers or persons controlling us pursuant to the foregoing provisions, we have been informed that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable. II-1

Confidential Treatment Requested by Nucana plc Pursuant to 17 C.F.R. Section 200.83

| Item 7. | Recent sales of unregistered securities |

None.

| Item 8. | Exhibits and Financial Statement Schedules |

(a) Exhibits

| Exhibit 
 Number  
 1.1*    
 3.1     |     | Description of Exhibits                                                                                                                                                                                                        
 Placement Agency Agreement, by and between Laidlaw & Company (UK) Ltd., dated    , 2025.                                                                                                                                       
 Articles of Association of the registrant (incorporated by reference to Exhibit 3.1 of the Company’s Registration Statement on Form S-8 filed with the SEC on March 7,                                                         
 2018).                                                                                                                                                                                                                         |
|:--------|:----|:-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 4.1*    |     | Form of certificate evidencing ordinary shares.                                                                                                                                                                                |
|