Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063906
Chunk: 480

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 480
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2. (17)Reserved. (18)Incorporated by reference to our Current Report on Form 6 -Kfiled on December 9, 2022. (19)Incorporated by reference to our Annual Report on Form 20 -F/A filed on January 17, 2023. (20)Incorporated by reference to our Current Report on Form 6 -Kfiled on March 27, 2023. (21)Incorporated by reference to our annual report on Form 20 -Ffiled on April 28, 2023. (22)Incorporated by reference to our Current Report on Form 6 -Kfiled on September 11, 2023. (23)Incorporated by reference to our Current Report on Form 6 -Kfiled on June 30, 2023. (24)Incorporated by reference to our Current Report on Form 6 -Kfiled on January 7, 2025. (25)Incorporated by reference to our Annual Report on Form 20 -Ffiled on April 30, 2024. (26)To be filed via amendment. II-6

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S -4and has duly caused this proxy statement/prospectus to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New York, State of New York, on July14, 2025.

| Aptorum Group Limited |     |                                        |
| By:                   |     | /s/ Ian Huen                           |
|                       |     | Name: Ian Huen                         |
|                       |     | Title: Chief Executive Officer and     
 the Chairman of the Board of Directors |

Pursuant to the requirements of the Securities Act of 1933, as amended, this proxy statement/prospectus has been signed by the following persons in the capacities set forth below on July14, 2025.

| /s/ Ian Huen           |     | Chief Executive Officer and Chairman of the Board of Directors |
| Name: Ian Huen         |     | -principal executive officer                                   |
| /s/ K. K. Wong         |     | Head of Finance                                                |
| Name