Company: NCNA
Filing Date: 2025-06-27
Form Type: 424B5
Source: 0001193125-25-151464
Chunk: 18

Company: NuCana plc
Filing Date: 2025-06-27
Form: 424B5
Chunk 18
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,000. The remaining sales proceeds, after deducting any expenses payable by us and any transaction fees imposed by any governmental,
regulatory, or self-regulatory organization in connection with the sales, will equal our net proceeds for the sale of such ADSs.

Because
there are no minimum sale requirements as a condition to this offering, the actual total public offering price, commissions and net proceeds to us, if any, are not determinable at this time. The actual dollar amount and number of ADSs we sell
through this prospectus supplement will be dependent, among other things, on market conditions and our capital raising requirements.

We
will report at least quarterly the number of shares of ADSs sold through the Sales Agents under the Sales Agreement, the net proceeds to us and the compensation paid by us to the Sales Agents in connection with the sales of ADSs under the Sales
Agreement.

In connection with the sale of the ADSs on our behalf, each of the Sales Agents will be deemed to be an
“underwriter” within the meaning of the Securities Act, and the compensation of the Sales Agents will be deemed to be underwriting commissions or discounts. We have agreed to provide indemnification and contribution to the Sales Agents
against certain civil liabilities, including liabilities under the Securities Act.

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The Sales Agents will not engage in any market making activities involving our ADSs while
the offering is ongoing under this prospectus supplement if such activity would be prohibited under Regulation M or other anti-manipulation rules under the Securities Act. The Sales Agents will not engage in any transactions that stabilizes our
ADSs.

The offering pursuant to the Sales Agreement will terminate upon the earlier of (i) the sale of all shares of ADSs subject to
the Sales Agreement and (ii) termination of the Sales Agreement as permitted therein. We may terminate the Sales Agreement in our sole discretion at any time by giving 5 days’ prior notice to the Sales Agents. The Sales Agents may
terminate the Sales Agreement under the circumstances specified in the Sales Agreement and in their sole discretion at any time by giving 5 days’ prior notice to us.

The Sales Agents and/or their affiliates have provided, and may in the future provide, various investment banking and other financial services
for us, for which services they have received and may in the future receive customary fees.

This prospectus supplement in electronic
format may be made available on a website maintained by the Sales Agents and the Sales Agents may distribute this prospectus supplement electronically.

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