Company: CLM
Filing Date: 2025-04-21
Form Type: 424B3
Source: 0001398344-25-007380
Chunk: 2

Company: Cornerstone Strategic Investment Fund, Inc.
Filing Date: 2025-04-21
Form: 424B3
Chunk 2
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 $            | 6.61 |     |           | None |     | $              | 556,907,892 |

| (1) | Because the Subscription                                                                                                 
 Price will not be determined until after printing and distribution of this prospectus, the “Estimated Subscription       
 Price” above is an estimate of the subscription price based on the Fund’s per-Share NAV and market price at the close of 
 trading on April 17, 2025. See “The Offering - Subscription Price” and “The Offering - Payment for                       
 Shares.”                                                                                                                 |

| (2) | Proceeds to the Fund are                                                                                                               
 before deduction of expenses incurred by the Fund in connection with the Offering, such expenses are estimated to be approximately     
 $636,000 or approximately $0.002 per Share, if fully subscribed. The calculation of the per Share amount does not take into account    
 the Over-Subscription Shares. Funds received prior to the final due date of this Offering will be deposited in a segregated account    
 pending allocation and distribution of Shares. Interest, if any, on subscription monies will be paid to the Fund regardless of whether 
 Shares are issued by the Fund; interest will not be used as credit toward the purchase of Shares.                                      |

| (3) | Fees and expenses incurred                                                                                                         
 by the Fund in connection with the Offering are estimated to be approximately $636,000 or approximately $0.002 per Share, if fully 
 subscribed. Proceeds to the Fund, after deduction of such fees and expenses incurred by the Fund in connection with the Offering,  
 are estimated to be approximately $556,271,979 or approximately $1.65 per Share, if fully subscribed. The calculation of the per   
 Share amounts indicated above do not take into account the Over-Subscription Shares.                                               |

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is April 21, 2025.</div>

The Fund’s Shares are listed on the NYSE American
under the ticker symbol “CLM.”

Investment Adviser.Cornerstone Advisors,
LLC (the “Investment Adviser”) acts as the Fund’s investment adviser. See “Management of the Fund.” As
of December 31, 2024, the Investment Adviser managed one other closed-end fund with combined assets with the Fund of approximately