Company: SXTPW
Filing Date: 2025-09-05
Form Type: 424B5
Source: 0001213900-25-085050
Chunk: 2

Company: 60 DEGREES PHARMACEUTICALS, INC.
Filing Date: 2025-09-05
Form: 424B5
Chunk 2
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| Where You Can Find More Information                  | S-26  |
| Information Incorporated by Reference                | S-27  |

<div align='center'>Prospectus</div>

| ABOUT THIS PROSPECTUS                                |  ii |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS | iii |
| MARKET, INDUSTRY AND OTHER DATA                      |  iv |
| PROSPECTUS SUMMARY                                   |   1 |
| RISK FACTORS                                         |  18 |
| USE OF PROCEEDS                                      |  19 |
| DIVIDEND POLICY                                      |  19 |
| THE SECURITIES WE MAY OFFER                          |  20 |
| DESCRIPTION OF CAPITAL STOCK                         |  21 |
| DESCRIPTION OF WARRANTS                              |  23 |
| DESCRIPTION OF DEBT SECURITIES                       |  24 |
| DESCRIPTION OF UNITS                                 |  30 |
| LEGAL OWNERSHIP OF SECURITIES                        |  31 |
| PLAN OF DISTRIBUTION                                 |  34 |
| LEGAL MATTERS                                        |  35 |
| EXPERTS                                              |  35 |
| WHERE YOU CAN FIND MORE INFORMATION                  |  35 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE    |  36 |

<div align='center'>S-i

ABOUT THIS PROSPECTUS SUPPLEMENT</div>

This prospectus supplement
and the accompanying base prospectus form part of a registration statement on Form S-3 that we filed with the Securities and Exchange
Commission, or SEC, utilizing a “shelf” registration process, on July 12, 2024, which was declared effective by the SEC on
July 18, 2024.

This document contains two
parts. The first part consists of this prospectus supplement, which provides you with specific information about this offering. The second
part, the accompanying base prospectus, provides more general information, some of which may not apply to this offering. Generally, when
we refer only to the “prospectus,” we are referring to both parts combined. This prospectus supplement may add, update or
change information contained in the accompanying base prospectus. To the extent that any statement we make in this prospectus supplement
is inconsistent with statements made in the accompanying base prospectus or any documents incorporated by reference herein or therein,
the statements made in this prospectus supplement will be deemed to modify or supersede those made in the accompanying base