Company: TAK
Filing Date: 2025-06-26
Form Type: 424B5
Source: 0001395064-25-000101
Chunk: 18

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-26
Form: 424B5
Chunk 18
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       |
| Total equity                                                                     |     |                                                     5,177.2 |          |     |      5,683.5 |          |     |      6,354.7 |          |     |      7,274.0 |          |     |              |  6,936.0 |       |

<div align='center'>S-13</div>

### DESCRIPTION OF THE NOTES AND THE GUARANTEE
The following description supplements and, to the extent it is inconsistent, replaces the general description of the debt securities and the TUSFI Indenture contained in the accompanying prospectus under the caption “Description of Senior Debt Securities and Guarantee.” The following description of the Notes and the Guarantee is a summary of the detailed provisions of the Notes, the Guarantee and the TUSFI Indenture described herein. It does not purport to be complete. This summary is subject to and is qualified by reference to all the provisions of the Notes, the Guarantee and the TUSFI Indenture, including the definitions of certain terms used therein. You are urged to read those documents in their entirety because they, and not this description, define the rights of holders of the Notes. Capitalized terms used but not defined here or elsewhere in the prospectus supplement shall have the meaning prescribed to them in the TUSFI Indenture and the Notes. Whenever particular sections or defined terms of the TUSFI Indenture not otherwise defined herein are referred to, such sections or defined terms are incorporated herein by reference. The forms of the Notes, the Guarantee and the TUSFI Indenture have been filed as exhibits to the registration statement of which this prospectus supplement and the accompanying prospectus form a part. You may also request copies of those documents upon written request from the corporate trust office of the Trustee located at 240 Greenwich Street, New York, New York 10286.

The Notes (including the Guarantee) will be issued pursuant to the TUSFI Indenture to be dated on or around , 2025 among the Issuer, the Guarantor, The Bank of New York Mellon, a banking corporation organized under the laws of New York, as Trustee, The Bank of New York Mellon, London Branch, as London paying agent, and The Bank of New York Mellon SA/NV, Dublin Branch, as registrar. The Bank of New York Mellon will initially act as paying agent, transfer agent and registrar for the Notes.

#### General
The Notes will be issued only in