Company: ADPT
Filing Date: 2025-03-03
Form Type: 10-K
Source: 0000950170-25-030913
Chunk: 21

Company: Adaptive Biotechnologies Corp
Filing Date: 2025-03-03
Form: 10-K
Item: Item 1
Chunk 21
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 new drug (“IND”) for a cell therapy product candidate was secured by Genentech. This milestone established an important TCR-based cell therapy product candidate proof of concept that supports our antigen-specific TCR discovery approach. 

The IM business is also advancing a pipeline of potential immune-based therapies in autoimmune disorders such as MS and T1D, among other indications. In autoimmunity, the immune system attacks self-antigens, which are human proteins normally found in our body. Specifically, T cells lose their ability to distinguish ‘self’ from ‘non-self’ antigens which may cause disease. Both MS and T1D, for example, are T-cell mediated diseases that involve mostly unknown self-antigens for which current treatments lack specificity to disease-causing targets, leading to suboptimal efficacy and risk of significant side effects. In MS and T1D, we’ve successfully identified the subset of ‘autoreactive’ TCRs that are likely causing these devastating diseases. Therapeutically, our goal is to develop antibodies that directly eliminate or block the activation of these problem T cells and stop them from attacking healthy tissue. Functional characterization of select antibodies is ongoing with the goal of developing a robust preclinical data package, following which we aim to designate a therapeutic candidate.

IM Pharma Partnering

We are focused on partnering with major pharmaceutical and well-capitalized biotechnology companies to offer our sequencing services ("IM Pharma"). Specifically, we use our core immune repertoire sequencing capabilities to deliver to our customers rich immune receptor data that help to inform their drug development programs. A key application of our immune receptor data is to understand and monitor a patient’s immune response to a given drug in a clinical trial. Our datasets combined with our deep expertise in understanding the adaptive immune system enables us to support our partners in advancing their own pipeline of innovative medicines across indications and drug modalities. We use revenue from our IM Pharma partnerships to directly offset our own internal research and development investments in the drug discovery efforts of our IM business. 

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Our Competitive Strengths 

We harness the inherent biology of the adaptive immune system to develop clinical products and services that improve human health by leveraging our core competitive strengths. 

•Our clonoSEQ test is the only NGS based assay with broad reimbursement in the U.S. used to monitor MRD in multiple lymphoid malignancies that can obtain a sensitivity of detection of 1 in 1,000,000 cancer cells. This uniquely positions us to continue to gain clinical adoption in diagnostic testing for hematologic malignancies.