Company: RVRC
Filing Date: 2025-10-03
Form Type: S-1/A
Source: 0001213900-25-096094
Chunk: 8

Company: Revium Rx.
Filing Date: 2025-10-03
Form: S-1/A
Chunk 8
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 the markets in which we operate is based on information
from independent industry and research organizations, other third-party sources (including industry publications, surveys and forecasts),
and management estimates. Management estimates are derived from publicly available information released by independent industry analysts
and third-party sources, as well as data from our internal research, and are based on assumptions made by us upon reviewing such data
and our knowledge of such industry and markets, which we believe to be reasonable. Although we believe the data from these third-party
sources is reliable, we have not independently verified any third-party information. In addition, projections, assumptions and estimates
of the future performance of the industry in which we operate and our future performance are necessarily subject to uncertainty and risk
due to a variety of factors, including those described in “Risk Factors” and “Cautionary Note Regarding Forward-Looking Statements.” These and other factors could cause results to differ materially from those expressed in the estimates made by
the independent parties and by us.

You should assume that
the information in this Prospectus is accurate only as of the date on the front of the document and that any information we have incorporated
by reference is accurate only as of the date of the document incorporated by reference, regardless of the time of delivery of this Prospectus
or any sale of securities.

<div align='center'>ii

GLOSSARY OF TECHNICAL TERMS USED</div>

The following are the meanings to be ascribed
to technical terms used throughout the prospectus.

“Antimicrobial Resistance (AMR)” is
the ability of microorganisms (bacteria, viruses, fungi, and parasites) to resist the effects of medications that once could successfully
treat them, leading to reduced treatment efficacy and increased health risks.

“Angiotensin II Type 1 Receptor (AT1)”
refers to a receptor involved in the renin-angiotensin system that regulates blood pressure and fluid balance; it also plays a role in
tumor biology and fibrosis.

“Ceramide Carbamoyl Spermine (CCS)”
is a synthetic cationic lipid composed of a ceramide backbone linked to a spermine-derived polyamine. CCS is used in advanced drug delivery
systems, particularly liposomal and nanoparticle formulations, for its ability to enhance cellular uptake and facilitate endosomal escape.
Its structure enables strong interaction with negatively charged cell membranes, making it especially effective for delivering nucleic
acids and other therapeutic payloads into target cells.

“BSL