Company: PAYX
Filing Date: 2025-04-08
Form Type: 424B2
Source: 0001193125-25-075170
Chunk: 43

Company: PAYCHEX INC
Filing Date: 2025-04-08
Form: 424B2
Chunk 43
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 addresses of the persons entitled thereto as such addresses shall appear in the register of notes or by wire transfer of immediately available funds to the accounts
of the holders of such definitive notes if appropriate wire transfer instructions have been received in writing by the paying agent not less than 15 days prior to the applicable interest payment date. Notwithstanding the foregoing, we will make
payments of interest on any interest payment date (other than on the maturity date or any redemption date) to each registered holder of $5,000,000 or more in aggregate principal amount of definitive notes by wire transfer of immediately available
funds if the applicable registered holder has delivered appropriate wire transfer instructions in writing to the paying agent not less than 15 days prior to the applicable interest payment date. Any wire transfer instructions received by the paying
agent shall remain in effect until revoked by the applicable registered holder.

S-26

U.S. FEDERAL INCOME TAX CONSIDERATIONS The following are the material U.S. federal income tax consequences of ownership and disposition of the notes. This discussion applies only to notes that meet both of the following conditions:

| • |     | they are purchased by those initial holders who purchase notes at the “issue price,” which will equal                                                                                                                                            
 the first price to the public (not including bond houses, brokers or similar persons or organizations acting in the capacity of underwriters, placement agents or wholesalers) at which a substantial amount of the notes is sold for money; and |

| • |     | they are held as capital assets within the meaning of Section 1221 of the Internal Revenue Code of 1986, as 
 amended (the “Code”).                                                                                       |

This discussion does not describe all aspects of U.S. federal income taxes and does not deal with all of the tax consequences that may be relevant to holders in light of their particular circumstances or to holders subject to special rules such as:

| • |     | financial institutions; |

| • |     | insurance companies; |

| • |     | dealers or traders using a                             
 mark-to-market method of tax accounting for the notes; |

| • |     | persons holding notes as part of a hedge, “straddle” or integrated transaction; |

| • |     | U.S. Holders (as defined below) whose functional currency is not the U.S. dollar; |

| • |     | regulated investment companies or real estate investment trusts; |

| • |     | partnerships or other entities or arrangements classified as partnerships for U.S. federal income tax purposes