Company: SHPH
Filing Date: 2025-04-21
Form Type: DEFR14A
Source: 0001641172-25-005474
Chunk: 48

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-04-21
Form: DEFR14A
Chunk 48
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 guest.

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What is the difference between holding shares as a sTOCKholder of record and as a beneficial owner?

Stockholders of Record (shares registered in your name):

You hold your shares directly and may vote your shares in accordance with the instructions on your proxy card.

Beneficial Owners (shares registered in the name of your broker, bank or other nominee):

You hold your shares through a brokerage firm and will have to provide instructions to your broker to vote your shares for you.

How do I vote and what are the voting deadlines?

Stockholders of Record (shares registered in your name):

| VIA                 
 THE INTERNET        
 BY                  
 TELEPHONE           |     | VOTE                                                                                                                                       
 BY INTERNET - www.proxyvote.com or scan the QR Barcode available on your proxy card. Use the Internet to transmit your voting instructions 
 and for electronic delivery of information. Vote by 11:59 P.M. ET on May 8, 2025. Have your proxy card in hand when you access the         
 web site and follow the instructions to obtain your records and to create an electronic voting instruction form.                           
 VOTE                                                                                                                                       
 BY PHONE - 1 - 800 - 690 - 6903 - Use any touch-tone telephone to transmit your voting instructions. Vote by 11:59 P.M. ET on May          
 8, 2025. Have your proxy card in hand when you call and then follow the instructions.                                                      |
|:--------------------|:----|:-------------------------------------------------------------------------------------------------------------------------------------------|
| BY                  
 MAIL                |     | VOTE                                                                                                                                       
 BY MAIL - Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, 
 c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.                                                                                       |
| AT                  
 THE VIRTUAL MEETING |     | Attend                                                                                                                                     
 the virtual meeting by going to www.virtualshareholdermeeting.com/SHPH2025 and logging in using the information contained on your          
 proxy card.                                                                                                                                |
| DEADLINE            |     | In                                                                                                                                         
 order for your vote to count, you must vote by May 8, 2025 at 11:59 P.M. ET. After that, the only way to cast your vote will be            
 by attending the meeting on May 9, 2025 at 12 pm EST.                                                                                      |

Can I change my vote or revoke my proxy?

Stockholders of Record (shares registered in your name