Company: PRME
Filing Date: 2025-07-02
Form Type: PRE 14A
Source: 0001193125-25-155000
Chunk: 3

Company: Prime Medicine, Inc.
Filing Date: 2025-07-02
Form: PRE 14A
Chunk 3
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PRIME MEDICINE, INC.

60 First Street

Cambridge, MA 02141

PROXY STATEMENT FOR THE 2025 SPECIAL MEETING OF STOCKHOLDERS

To Be Held on August 1, 2025

The Board of Directors of Prime Medicine, Inc. (the “Board of Directors,” “Board,” or “our Board”) is soliciting
proxies from stockholders for its use at the 2025 special meeting of our stockholders (the “Special Meeting”), and at any continuation, postponement, or adjournment of that meeting. The Special Meeting is scheduled to be held on
August 1, 2025, at 1:00 p.m., Eastern Time, in a virtual meeting format, which will be conducted via live webcast at www.virtualshareholdermeeting.com/PRME2025SM. In this proxy statement, “we,” “our,” “us,”
the “Company,” “Prime,” “Prime Medicine,” and similar designations refer to Prime Medicine, Inc. and, where appropriate, our subsidiary. The mailing address of our principal executive offices is Prime Medicine, Inc., 60
First Street, Cambridge, MA 02141.

Please see the “Information About the Special Meeting and Voting” section of this proxy
statement for more details regarding the logistics of the virtual Special Meeting, including the ability of stockholders to submit questions during the Special Meeting, and technical details and support related to accessing the virtual platform.
There is no physical location for the Special Meeting. You will not be able to attend the Special Meeting in person.

All properly
submitted proxies will be voted in accordance with the instructions contained in those proxies. If no instructions are specified, the proxies will be voted in accordance with the recommendation of the Board of Directors with respect to each of the
matters set forth in the accompanying proxy card. You may revoke your proxy at any time before it is exercised at the meeting by giving our Corporate Secretary written notice to that effect.

On or about July , 2025, we will commence mailing this proxy statement and form of proxy card to all stockholders of record entitled to
notice of, and to vote at, the Special Meeting.

IMPORTANT NOTICE REGARDING THE AVAILABILITY OF PROXY MATERIALS FOR THE 2025 SPECIAL STOCKHOLDER MEETING TO BE HELD ON AUGUST 1, 2025

This proxy statement and the accompanying proxy card are available for viewing, printing and downloading atwww