Company: EDSA
Filing Date: 2025-09-09
Form Type: 424B5
Source: 0001171843-25-005799
Chunk: 2

Company: Edesa Biotech, Inc.
Filing Date: 2025-09-09
Form: 424B5
Chunk 2
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 S-3.

Investing in our common shares involves a high degree of risk. Before making any decision to invest in our common shares, you should carefully consider the information disclosed in this this prospectus supplement and the accompanying prospectus, including the information under “ Risk Factors” beginning on page S-7 of this prospectus supplement, as well as the information, including the risk factors, incorporated by reference into this prospectus supplement and the accompanying prospectus as described under the heading “ Where You Can Find More Information.”

NEITHER THE SECURITIES AND EXCHANGE COMMISSION
NOR ANY STATE SECURITIES COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR PASSED UPON THE ADEQUACY OR ACCURACY OF THIS PROSPECTUS
SUPPLEMENT AND THE ACCOMPANYING PROSPECTUS. ANY REPRESENTATION TO THE CONTRARY IS A CRIMINAL OFFENSE.

THE SECURITIES OFFERED BY THIS PROSPECTUS SUPPLEMENT HAVE NOT BEEN QUALIFIED FOR DISTRIBUTION IN CANADA AND MAY NOT BE OFFERED OR SOLD IN CANADA EXCEPT PURSUANT TO AN EXEMPTION FROM THE PROSPECTUS REQUIREMENTS UNDER APPLICABLE CANADIAN SECURITIES LAWS. THE COMPANY HAS NOT FILED AND DOES NOT INTEND TO FILE A CANADIAN PROSPECTUS IN CONNECTION WITH THE SECURITIES OFFERED BY THIS PROSPECTUS SUPPLEMENT.**

<div align='center'>H.C. Wainwright & Co.

The date of this prospectus supplement is September 9, 2025.

TABLE OF CONTENTS</div>

|                                                 | Page |
| PROSPECTUS SUPPLEMENT                           |      |
| ABOUT THIS PROSPECTUS SUPPLEMENT                | S-1  |
| SPECIAL NOTE ON FORWARD-LOOKING STATEMENTS      | S-3  |
| SUMMARY                                         | S-5  |
| THE OFFERING                                    | S-6  |
| RISK FACTORS                                    | S-7  |
| USE OF PROCEEDS                                 | S-9  |
| DIVIDEND POLICY                                 | S-10 |
| DILUTION                                        | S-11 |
| CERTAIN TAX MATTERS                             | S-12 |
| PLAN OF DISTRIBUTION                            | S-21 |
| LEGAL MATTERS                                   | S-23 |
| EXPERTS                                         | S-24 |
| WHERE YOU CAN FIND MORE INFORMATION             | S-25 |
| INCORPORATION