Company: ARWR
Filing Date: 2025-12-11
Form Type: S-3ASR
Source: 0001193125-25-314755
Chunk: 42

Company: ARROWHEAD PHARMACEUTICALS, INC.
Filing Date: 2025-12-11
Form: S-3ASR
Chunk 42
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 statement of which it forms a part. S-14

Up to $500,000,000

Common Stock

Prospectus Supplement

December 10, 2025

Jefferies

PART II INFORMATION NOT REQUIRED IN PROSPECTUS Item 14. Other Expenses of Issuance and Distribution . The following table sets forth the costs and expenses, other than the underwriting discounts and commissions, payable by the registrant in connection with the issuance and distribution of the securities registered hereby.

| Item                             |     | Amount to 
 be paid   |     |    |
|:---------------------------------|:----|:----------|:----|:---|
| SEC registration fee             |     | $         |     | *  |
| Nasdaq listing fee               |     |           |     | ** |
| Printing and engraving expenses  |     |           |     | ** |
| Legal fees and expenses          |     |           |     | ** |
| Accounting fees and expenses     |     |           |     | ** |
| Transfer Agent fees and expenses |     |           |     | ** |
| Miscellaneous expenses           |     |           |     | ** |
| Total                            |     | $         |     | ** |

| * | The registrant is deferring payment of the registration fee in reliance on Rule 456(b) and Rule 457(r) under                                                                                              
 the Securities Act, other than the $69,050 of fees due in connection with the $500,000,000 of our common stock that may be issued and sold from time to time under the Sale Agreement with Jefferies LLC. |

| ** | Estimated expenses are not presently known. The foregoing sets forth the general categories of expenses (other                                                                                                                                           
 than underwriting discounts and commissions) that we anticipate we will incur in connection with the offering of securities under this registration statement. An estimate of the aggregate expenses in connection with the issuance and distribution of 
 the securities being offered will be included in the applicable prospectus supplement.                                                                                                                                                                   |

Item 15. Indemnification of Directors and Officers . The Certificate of Incorporation provides for the elimination of personal monetary liability of directors to the fullest extent permissible under Delaware law. Delaware law does not permit the elimination or limitation of director monetary liability for: (i) breaches of the director’s duty of loyalty to the corporation or its stockholders; (ii) acts or omissions not in good faith or involving intentional misconduct or knowing violations of law; (iii) the payment of