Company: PRME
Filing Date: 2025-05-19
Form Type: DEFA14A
Source: 0001193125-25-122158
Chunk: 10

Company: Prime Medicine, Inc.
Filing Date: 2025-05-19
Form: DEFA14A
Chunk 10
---
 furnished herewith.    |
|:--------|:----|:----------------------------------------------------------------------------|
| 99.3    |     | Presentation, dated May 2025, furnished herewith.                           |
| 104     |     | Cover Page Interactive Data File (embedded within the Inline XBRL document) |

SIGNATURE Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. Date: May 19, 2025

| Prime Medicine, Inc. |     |                         |
| By:                  |     | /s/ Allan Reine         |
| Name:                |     | Allan Reine, M.D.       |
| Title:               |     | Chief Executive Officer |