Company: RVRC
Filing Date: 2025-08-13
Form Type: S-1/A
Source: 0001213900-25-075747
Chunk: 221

Company: Revium Rx.
Filing Date: 2025-08-13
Form: S-1/A
Chunk 221
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 for the
cancellation of their options without any claims, rights, obligations, damages and liabilities of any nature pursuant to the termination
of their terminated options.

<div align='center'>F-43

[RESALE PROSPECTUS ALTERNATE PAGE]</div>

The information in this Prospectus is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and is not soliciting an offer to buy these securities in any state or other jurisdiction where the offer or sale is not permitted.

| PRELIMINARY PROSPECTUS | SUBJECT       
 TO COMPLETION | DATED          
 AUGUST__, 2025 |

<div align='center'>REVIUM RX.

Up to 37,625,790 Shares of Common Stock</div>

This Resale Prospectus
relates to the resale, from time to time, of up to an aggregate of 37,625,790 shares of our Common Stock, including 6,372,265 shares of
Common Stock issuable upon exercise of Investor Warrants. by the Selling Stockholders identified in this Resale Prospectus under the caption
“Selling Stockholders.” We are not selling any shares of our Common Stock under this Resale Prospectus, and we will not receive
any proceeds from the sale of Shares of Common Stock offered hereby by the Selling Stockholders, although we may receive $7,413,436 from
the exercise of the outstanding Investor Warrants, if they are exercised for cash.

Investing in our securities involves a high degree of risk. See “Risk Factors” beginning on page 5 of this prospectus for a discussion of information that should be considered in connection with an investment in our securities.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is _______________,
2025.

TABLE OF CONTENTS</div>

|                         |     | Page   |
| About This Prospectus   |     | Alt-ii |
| Summary of the Offering |     | Alt-1  |
| Selling Stockholders    |     | Alt-2  |
| Use of Proceeds         |     | Alt-6  |
| Plan of Distribution    |     | Alt-7  |

<div align='center