Company: PTHS
Filing Date: 2025-09-29
Form Type: 424B3
Source: 0001753926-25-001561
Chunk: 0

Company: Pelthos Therapeutics Inc.
Filing Date: 2025-09-29
Form: 424B3
Chunk 0
---
| Filed Pursuant to Rile 424(b)(3) |
| Registration No. 333-289916      |

PROSPECTUS

<div align='center'>UP TO 8,137,868 Common Shares

Pelthos Therapeutics Inc.</div>

This prospectus relates to the resale,
from time to time, of up to 8,137,868 shares of common stock, par value $0.0001 per share (the “Common Stock”) of Pelthos
Therapeutics Inc. (the “Company”, “we”, “us” or “our”), a Nevada corporation, by
the certain investors (collectively, the “Selling Stockholders”) signatory to that certain Securities Purchase Agreement
(as amended, modified or waived from time to time, the “Securities Purchase Agreement”) dated April 16, 2025, by and
among the Company, LNHC, Inc., a Delaware corporation (“LNHC”) and such investors, which include Nomis Bay Ltd (“Nomis
Bay”) and Ligand Pharmaceuticals Incorporated (“Ligand”), a Delaware corporation.

The Selling Stockholders may sell or otherwise
dispose of the shares of Common Stock described in this prospectus in a number of different ways and at varying prices. If any
underwriters, dealers, or agents are involved in the sale of any of the shares of Common Stock, their names and any applicable
purchase price, fee, commission, or discount arrangement between or among them will be set forth, or will be calculable from the
information set forth, in any applicable prospectus supplement. We will pay the expenses incurred in registering under the Securities
Act the offer and sale of the shares of Common Stock to which this prospectus relates by the Selling Stockholder, including our
legal and accounting fees. See the sections “About this Prospectus” on page 1 and “Plan of Distribution”
on page 46 of this prospectus for more information. No shares of Common Stock may be sold without delivery of this prospectus
and any applicable prospectus supplement describing the method and terms of the offering of such shares of Common Stock. You should
carefully read this prospectus and any applicable prospectus supplement before you invest in our securities.

Our Common Stock is currently listed
on the NYSE American LLC (the “NYSE American”) under the symbol “PTHS”. On September 24, 2025, the last reported
sale price of our Common Stock on NYSE American was $33.