Company: HURA
Filing Date: 2025-12-10
Form Type: 424B5
Source: 0001193125-25-313799
Chunk: 25

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-12-10
Form: 424B5
Chunk 25
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,000,000

Debt Securities

Common Stock

Preferred Stock

Warrants

Subscription Rights

Units

Purchase Contracts

4,570,629 Shares of Common Stock

Up to 4,750,916 Shares of Common Stock Issuable Upon Exercise of Warrants

We may offer and sell from time to time up to $250,000,000 of any combination of the securities described in this prospectus, in one or more
classes or series and in amounts, at prices and on terms that we will determine at the times of the offerings.

In addition, this
prospectus relates to the offer and sale from time to time of up to 9,321,545 shares of our Common Stock, comprising up to (i) 4,570,629 shares of our Common Stock and (ii) 4,750,916 shares of our Common Stock issuable upon the exercise of warrants
under this prospectus by the selling stockholders identified in the “Selling Stockholders” section of this prospectus or their permitted transferees, pledgees, donees or other successors in interest. The selling stockholders or their
permitted transferees, pledgees, donees or other successors in interest may sell the shares of Common Stock in a number of different ways and at varying prices. We provide more information about how the selling stockholders may sell the shares of
Common Stock in the section of this prospectus titled “Plan of Distribution - Selling Stockholders Plan of Distribution.” We will not receive any of the proceeds from the sale of our Common Stock by the selling stockholders. We have paid
or will pay the fees and expenses incident to the registration of the shares of Common Stock for sale by the selling stockholders. The selling stockholders will bear all discounts, concessions, commissions and stock transfer taxes, if any,
attributable to their sales of shares.

This prospectus describes the general manner in which our securities may be offered using this
prospectus. We will provide specific terms of the securities, including the offering prices, in one or more supplements to this prospectus. The supplements may also add, update, or change information contained in this prospectus. You should read
this prospectus and the prospectus supplement relating to the specific issue of securities carefully before you invest.

We or the selling
stockholders may offer the securities independently or together in any combination for sale directly to purchasers or through underwriters, dealers, or agents to be designated at a future date. The supplements to