Company: FITBI
Filing Date: 2025-11-05
Form Type: S-4
Source: 0001193125-25-267273
Chunk: 368

Company: FIFTH THIRD BANCORP
Filing Date: 2025-11-05
Form: S-4
Chunk 368
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 hereto or the fact that any signature or
agreement or instrument was transmitted or communicated through the use of a facsimile machine or e-mail delivery of a “.pdf” format data file as a defense to the formation of a contract and each
party hereto forever waives any such defense.

[Signature Page Follows]

A-61

IN WITNESS WHEREOF, each party has caused this Agreement to be executed by their respective officers thereunto duly authorized as of the date first above written.

| FIFTH THIRD BANCORP. |     |                                       |
| By:                  |     | /s/ Timothy N. Spence                 |
| Name:                |     | Timothy N. Spence                     |
| Title:               |     | President and Chief Executive Officer |

| FIFTH THIRD FINANCIAL CORPORATION |     |                                       |
| By:                               |     | /s/ Timothy N. Spence                 |
| Name:                             |     | Timothy N. Spence                     |
| Title:                            |     | President and Chief Executive Officer |

| COMERICA INCORPORATED |     |                         |
| By:                   |     | /s/ Curtis C. Farmer    |
| Name:                 |     | Curtis C. Farmer        |
| Title:                |     | Chairman, President and |
|                       |     | Chief Executive Officer |

| COMERICA HOLDINGS INCORPORATED |     |                                       |
| By:                            |     | /s/ Curtis C. Farmer                  |
| Name:                          |     | Curtis C. Farmer                      |
| Title:                         |     | President and Chief Executive Officer |

A-62

Exhibit A

Bank Merger Agreement

AGREEMENT AND PLAN OF MERGER OF

COMERICA BANK

AND

COMERICA BANK & TRUST, NATIONAL ASSOCIATION

WITH AND INTO

FIFTH THIRD BANK, NATIONAL ASSOCIATION

This Agreement and Plan of Merger (this “”), dated as of October
[●], 2025, is made by and among Fifth Third Bank, National Association, a national bank, Comerica Bank, a Texas state-chartered bank, and Comerica Bank & Trust, National Association, a national bank.

WITNESSETH:

WHEREAS, Fifth Third Bank, National Association is a national banking association duly organized and existing under the laws of the
United States, with its main office located in Cincinnati, Ohio, all the issued and outstanding capital stock of