Company: OSRH
Filing Date: 2025-04-22
Form Type: 10-K
Source: 0001213900-25-034116
Chunk: 35

Company: OSR Holdings, Inc.
Filing Date: 2025-04-22
Form: 10-K
Item: Item 1
Chunk 35
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 group. Additionally, when measuring the length of osteoid relative to the area of new bone, the AB204 (100µg) group showed the highest ratio.
     
    2014.06.
05 ~ 2014.
12.31
     
    Korea Animal
Medical Institute

    Mouse calvaria & Tibial defect fusion
     
    C3H Rats
     
    to evaluate the bone healing property of DRT-102 on Calvaria and Tibia osteotomy compared to rhBMP-2 in mouse.

    – DRT-102 facilitates the healing of the CSD (critical-sized defect)
    in the tibia of rats.
     
    – CT scans and histological analyses showed that only DRT-102 was
    effective in healing the segment.
     
    2011.10.
01 ~ 2014.
9.31
     
    JCB (joint center for biosciences)

    – Bone generated by BMP2 did not integrate well with the existing bone, with visible boundaries, whereas bone newly formed by DRT-102 completely fused with the existing bone without visible differences.

    – The fidelity of the newly formed bone was particularly observed in Villanueva-stained tissue slides, which showed osteoblasts and mineralized bone.

    In Vitro – Efficacy Test
     
    MC3T3-E1 cell
     
    To evaluate osteoinductivity of DRT-102 in MC3T3-E1 preosteblastic cells

    – DRT-102 was not toxic to the cells.
     
    – DRT-102 promoted calcium nodule formation three times
    more than BMP2
     
    – DRT-102 also increased ALP activity, another measure of
    osteogenic potential, by over 135% compared to BMP2
     
    2011.10.
01 ~ 2014.
09.31
     
    JCB (joint center for biosciences)

    Monkey fibular defect fusion
     
    Cynomolgus Monkey
     
    To evaluate the efficacy of DRT-102 on primates’ tibial bone defect
     
    – When 5 mg of AB204/DBM was administered, it produced more than twice the amount of mineralized tissue compared to the 5