Company: APM
Filing Date: 2025-10-14
Form Type: 424B5
Source: 0001213900-25-098635
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Company: Aptorum Group Ltd
Filing Date: 2025-10-14
Form: 424B5
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Filed pursuant to Rule 424(b)(5)

Registration No. 333-268873

<div align='center'>1,000,000 Class A Ordinary Shares

APTORUM GROUP LIMITED</div>

This is an offering of the securities of Aptorum
Group Limited (the “Company”, “we”, “our”, “us”, “APM”), a Cayman Islands
exempted company with limited liability.

We are offering 1,000,000 Class A Ordinary Shares
of par value of $0.00001 each (the “Class A Ordinary Shares”), to certain institutional investors pursuant to a securities
purchase agreement dated October 10, 2025 (the “Offering”). The purchase price of each Class A Ordinary Share is US$2.00.

In a concurrent private placement, we are also
selling to the investor warrants to purchase an aggregate of up to 2,000,000 of our Class A Ordinary Shares. The warrants are exercisable
immediately as of the date of issuance at an exercise price of $2.00 per Class A Ordinary Share and expire twenty-four months from the
effective date of a registration statement registering for resale the shares of Class A Ordinary Shares underlying such warrants. The
warrants and the Class A Ordinary Shares issuable upon the exercise of the warrants are not being registered under the Securities Act
of 1933, as amended, or the Securities Act, pursuant to the registration statement of which this prospectus supplement is a part and the
accompanying prospectus. The warrants and the Class A Ordinary Shares issuable upon the exercise of the warrants are being offered pursuant
to an exemption from the registration requirements of the Securities Act provided in Section 4(a)(2) of the Securities Act and/or Rule
506(b) of Regulation D.

The Class A Ordinary Shares are listed on the
Nasdaq Capital Market under the symbol “APM.” The last reported sale price of the Class A Ordinary Shares on October 13, 2025
was US$1.58 per Class A Ordinary Share.

We have retained H.C. Wainwright & Co., LLC
(the “Placement Agent” or “Wainwright”) as our placement agent to use its “reasonable best efforts”
to solicit offers to purchase our shares in this offering. The Placement Agent has no obligation to buy any of the securities from us
or to arrange for the purchase or sale of any specific number or dollar amount of securities.

We will pay all of the expense’s