Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063899
Chunk: 435

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 435
---
 amended,
the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form F-1 and has
duly caused this prospectus to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New York, State of
New York, on July 14, 2025.

| Aptorum Group Limited |                                        |
| By:                   | /s/ Ian Huen                           |
|                       | Name: Ian Huen                         |
|                       | Title: Chief Executive Officer and     
 the Chairman of the Board of Directors |

Pursuant to the requirements of the Securities Act of 1933, as amended,
this prospectus has been signed by the following persons in the capacities set forth below on July 14, 2025.

| /s/ Ian Huen           |     | Chief Executive Officer and Chairman of the Board of Directors 
 (principal                                                     |
| Name: Ian Huen         |     | executive officer)                                             |
| /s/                    
 K. K. Wong             |     | Head of Finance                                                |
| Name: K. K. Wong       |     |                                                                |
| /s/ Douglas Arner      |     | Director                                                       |
| Name: Douglas Arner    |     |                                                                |
| /s/ Charles Bathurst   |     | Director                                                       |
| Name: Charles Bathurst |     |                                                                |
| /s/ Mirko Scherer      |     | Director                                                       |
| Name: Mirko Scherer    |     |                                                                |
| /s/ Justin Wu          |     | Director                                                       |
| Name: Justin Wu        |     |                                                                |

<div align='center'>II-3

SIGNATURE OF AUTHORIZED REPRESENTATIVE IN THE UNITED STATES</div>

Pursuant to the requirements of the Securities Act of 1933, the Registrant’s
duly authorized representative has signed this prospectus on Form F-1 in the City of New York, State of New York, on July 14, 2025.

| By: | /s/ Louis Taubman                                     |
|     | Name: Louis Taubman                                   |
|     | Title: Authorized Representative in the United States |

<div align='center'>II-4

EXHIBIT INDEX</div>

(a) Exhibits.The following exhibits are included herein or
incorporated herein by reference:

The following documents are filed as part of this registration statement:

| Exhibit No. |