Company: HURA
Filing Date: 2025-05-06
Form Type: S-4/A
Source: 0001193125-25-113920
Chunk: 498

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-05-06
Form: S-4/A
Chunk 498
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, TuHURA cannot forecast which product candidates may be subject to future collaborations, when such arrangements will be secured, if at all, and to what degree such arrangements would affect TuHURA’s development plans and capital requirements. TuHURA’s future clinical development costs may vary significantly based on factors such as:

| • |     | per-patient trial costs; |

| • |     | the number of trials required for regulatory approval; |

| • |     | the number of sites included in the trials; |

| • |     | the countries in which the trials are conducted; |

| • |     | the length of time required to enroll eligible patients; |

| • |     | the number of patients that participate in the trials; |

| • |     | the number of doses that patients receive; |

| • |     | the drop-out or discontinuation rates of patients; |

| • |     | potential additional safety monitoring requested by regulatory agencies; |

| • |     | the phase of development of the product candidate; and |

| • |     | the efficacy and safety profile of the product candidate. |

Acquired In-ProcessResearch and Development (“IPR&D”) Acquired in-processresearch and development expenses consist of existing research and development projects at the time of the acquisition. Projects that qualify as IPR&D assets represent those that have not yet reached technological feasibility and have no alternative future use. TuHURA acquisitions of assets have included IPR&D assets that had not yet reached technological feasibility and had no alternative future use, which resulted in a write-offof these IPR&D assets to acquired in-processresearch and development expenses in TuHURA’s consolidated statement of operations. 307

General and Administrative Expenses General and administrative expenses consist primarily of salaries and employee-related costs, including stock-based compensation, for personnel in TuHURA’s executive, finance, and other administrative functions. Other significant costs include facility related costs, legal fees relating to intellectual property and corporate matters, professional fees for accounting and consulting services and insurance costs. TuHURA anticipates that its general and administrative expenses will increase in the future to support TuHURA’ continued research and development activities, and, if any product candidates receive marketing approval, commercialization activities. TuHURA also anticipates increased expenses related to audit, legal, regulatory, and tax-relatedservices associated with maintaining compliance with exchange listing and SEC requirements, director and officer insurance premiums and investor relations costs associated with operating as a public company. Other Income (Expense) Other income (expense