Company: INMB
Filing Date: 2025-06-16
Form Type: S-8
Source: 0001213900-25-054427
Chunk: 1

Company: Inmune Bio, Inc.
Filing Date: 2025-06-16
Form: S-8
Chunk 1
---
 Act. ☐

<div align='center'>EXPLANATORY NOTE</div>

This Registration Statement on Form S-8 (this
“Registration Statement”) also includes a prospectus (the “reoffer prospectus”) prepared in accordance with General
Instruction C of Form S-8 and in accordance with the requirements of Part I of Form S-3. This reoffer prospectus for shares
granted under the Second Amended and Restated INmune Bio Inc. 2021 Stock Incentive Plan (the “2021 Plan”) may be used for
the reoffer and resale of shares of common stock on a continuous or delayed basis that may be deemed to be “restricted securities”
and/or “control securities” within the meaning of the Securities Act of 1933, as amended (the “Securities Act”),
and the rules and regulations promulgated thereunder, that are issuable to certain of our executive officers, employees, consultants and
directors identified in the reoffer prospectus. The number of shares of common stock included in the reoffer prospectus represents
shares of common stock issuable to the selling stockholders pursuant to equity awards, including stock options and restricted stock grants,
granted to the selling stockholders and does not necessarily represent a present intention to sell any or all such shares of common stock.

Pursuant to the Registration Statement (the “Prior Registration
Statement”) on Form S-8 filed by INmune Bio Inc. (the “Company”) on June 20, 2023 (Registration No. 333-272770),
the Company previously registered an aggregate of 4,000,000 shares of its common stock. The additional shares of common
stock being registered by this Registration Statement are of the same class as those securities registered on the Prior Registration Statement
and represent an increase in the total shares available for issuance under the 2021 Plan by 2,500,000. Pursuant to General Instruction
E to Form S-8, the registrant incorporates by reference into this Registration Statement the contents of the Prior Registration Statement,
including all exhibits filed therewith or incorporated therein by reference, except as expressly modified herein.

<div align='center'>PART I

INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>

This Registration Statement relates to two separate
prospectuses.

: Items 1 and 2,
from this page, and the documents incorporated by reference pursuant to Part II, Item 3 of this prospect