Company: MBIO
Filing Date: 2025-02-05
Form Type: CORRESP
Source: 0001104659-25-009409
Chunk: 0

Company: MUSTANG BIO, INC.
Filing Date: 2025-02-05
Form: CORRESP
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<div align='center'>Mustang Bio, Inc.

377 Plantation Street

Worcester, Massachusetts 01605</div>

VIA EDGAR

February 5, 2025

Securities and Exchange Commission

Division of Corporation Finance

Office of Life Sciences

100 F Street, N.E.

Washington, D.C. 20549

Attn: Tim Buchmiller

| Re: | Mustang Bio, Inc.                                        |
|     | Registration Statement on Form S-1 (Reg. No. 333-284299) |
|     | Request for Acceleration of Effective Date               |

Ladies and Gentlemen:

Pursuant to Rule 461 under
the Securities Act of 1933, as amended, Mustang Bio, Inc. (the “Company”) hereby requests that the Securities and Exchange
Commission (the “Commission”) accelerate the effective date of the above-referenced Registration Statement on Form
S-1 (the “Registration Statement”) so that the Registration Statement will be declared effective as of 5:15 p.m. Eastern
time, on February 5, 2025, or as soon as practicable thereafter. The Company hereby authorizes Rakesh Gopalan or Alexander Yarbrough,
both of whom are attorneys at the Company’s outside legal counsel, Troutman Pepper Locke LLP, to orally modify or withdraw this
request for acceleration.

Once the Registration Statement
has been declared effective, please orally confirm that event with Mr. Gopalan at (704) 916-2374 or Mr. Yarbrough at (704) 998-4077.

Thank you for your assistance
in this matter.

| Very truly yours,   |                                                 |
| Mustang Bio, Inc.   |                                                 |
| /s/ Manuel Litchman |                                                 |
| Name:               | Manuel Litchman, M.D.                           |
| Title:              | President, Chief Executive Officer and Director |

| cc (via email): | Rakesh Gopalan, Troutman Pepper Locke LLP         
 Alexander T. Yarbrough, Troutman Pepper Locke LLP 
 Robert F. Charron, Ellenoff Grossman & Schole LLP 
 John J. Hart, Ellenoff Grossman & Schole LLP      |