Company: SCLXW
Filing Date: 2025-07-23
Form Type: 424B3
Source: 0001193125-25-163077
Chunk: 254

Company: Scilex Holding Co
Filing Date: 2025-07-23
Form: 424B3
Chunk 254
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 subject matter hereof and thereof and supersedes all prior

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and contemporaneous understandings and agreements related thereto (whether written or oral), all of which are merged herein. In the event of a conflict between the terms of the Merger Agreement
and this Amendment, the terms of this Amendment shall prevail solely as to the subject matter contained herein.

6.
. This Amendment may be executed in counterparts, each of which shall constitute an original, but all of which shall constitute one agreement. This Amendment shall become effective upon delivery to each party of an executed
counterpart or the earlier delivery to each party of original, photocopied, or electronically transmitted signature pages that together (but need not individually) bear the signatures of all other parties.

[The remainder of this page is intentionally left blank; signature pages to follow]

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IN WITNESS WHEREOF the parties hereto have caused this Amendment to be duly executed as of the day and year first written above.

| DENALI CAPITAL ACQUISITION CORP. |     |                                |
| By:                              |     | /s/ Lei Huang                  |
|                                  |     | Name: Lei Huang                |
|                                  |     | Title: Chief Executive Officer |
| DENALI MERGER SUB INC.           |     |                                |
| By:                              |     | /s/ Peter Xu                   |
|                                  |     | Name: Peter Xu                 |
|                                  |     | Title: President               |
| SEMNUR PHARMACEUTICALS, INC.     |     |                                |
| By:                              |     | /s/ Jaisim Shah                |
|                                  |     | Name: Jaisim Shah              |
|                                  |     | Title: Chief Executive Officer |