Company: SCLXW
Filing Date: 2025-12-16
Form Type: S-1
Source: 0001193125-25-319720
Chunk: 666

Company: Scilex Holding Co
Filing Date: 2025-12-16
Form: S-1
Chunk 666
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 policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

<div align='center'>II-17</div>

SIGNATURES Pursuant to the requirements of the Securities Act, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Palo Alto, State of California, on the 15th day of December 2025.

| Scilex Holding Company |     |                                              |
| By:                    |     | /s/ Henry Ji                                 |
|                        |     | Name: Henry Ji                               |
|                        |     | Title: Chief Executive Officer and President |

Each person whose signature appears below constitutes and appoints each of Henry Ji and Stephen Ma, acting alone or together with another attorney-in-fact,as his true and lawful attorney-in-factand agent, with full power of substitution and resubstitution, for such person and in his name, place and stead, in any and all capacities, to sign any or all further amendments (including post-effective amendments) to this registration statement (and any additional registration statement related hereto permitted by Rule 462(b) promulgated under the Securities Act of 1933, as amended (and all further amendments, including post-effective amendments thereto)), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-factand agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-factand agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

| Signature                                           
 /s/ Henry Ji, Ph.D. Henry Ji, Ph.D.                 
 /s/ Stephen Ma Stephen Ma                           |     | Title                                                                            
 Chief Executive Officer, President and Chairperson (Principal Executive Officer) 
 Chief Financial Officer (Principal Financial and Accounting Officer)             |     | Date              
 December 15, 2025 
 December 15, 2025 |
|:----------------------------------------------------|:----|:---------------------------------------------------------------------------------|:----|:----------------