Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119846
Chunk: 522

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 522
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 for the automatic annual increase on
January 1, 2024 pursuant to the Equity Incentive Plan.

Scilex Holding Company 2023 Inducement Plan

On January 17, 2023, the compensation committee of the Board of Directors of the Company adopted the Scilex Holding Company 2023 Inducement Plan (the
“Inducement Plan”). The Inducement Plan provides for the grant of equity-based awards in the form of non-statutory stock options, stock appreciation rights, restricted stock, restricted stock units,
and other awards solely to prospective employees of the Company or an affiliate of the Company, provided that certain criteria are met. The initial maximum number of shares available for grant under the Inducement Plan is 1,400,000 shares of Common
Stock (subject to adjustment for recapitalizations, stock splits, reorganizations and similar transactions). No awards were granted under the Inducement Plan during the years ended December 31, 2024 and 2023.

As of December 31, 2024, options to purchase 35,985,182 shares of Common Stock were outstanding under all equity incentive plans.

F-43

The following table summarizes stock option activity during the year ended December 31, 2024 (shares in thousands):

|                                                     |     | Options |        |   |     | Weighted-      
 Average        
 Exercise Price |      |     | Weighted-   
 Average     
 Remaining   
 Contractual 
 Life,       
 in years    |     |     | Aggregate 
 Intrinsic 
 Value     |       |
|:----------------------------------------------------|:----|:--------|-------:|:--|:----|:---------------|-----:|:----|:------------|----:|:----|:----------|------:|
| Outstanding as of December 31, 2023                 |     |         | 33,124 |   |     | $              | 4.38 |     |             | 7.5 |     | $         | 7,459 |
| Granted                                             |     |         |  4,515 |   |     | $              | 0.95 |     |             |     |     |           |       |
| Exercised                                           |     |         |   (154 | ) |     | $              | 1.48 |     |             |     |     |           |       |
| Forfeited/Cancelled                                 |     |         | (1,