Company: USCB
Filing Date: 2025-11-07
Form Type: S-4
Source: 0001193125-25-272361
Chunk: 0

Company: USCB FINANCIAL HOLDINGS, INC.
Filing Date: 2025-11-07
Form: S-4
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As filed with the Securities and Exchange Commission on November 7, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-4 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 USCB FINANCIAL HOLDINGS, INC. (Exact Name of Registrant as Specified in Its Charter)

| Florida                         |     |                         6022 |     | 87-4070846            |
| (State or Other Jurisdiction of 
 Incorporation or Organization)  |     | -Primary Standard Industrial 
   Classification Code Number |     | -IRS Employer         
 Identification Number |

2301 N.W. 87 thAvenue Doral, FL 33172 (305) 715-5200 (Address, Including Zip Code, and Telephone Number, Including Area Code, of Registrant’s Principal Executive Offices) Robert Anderson Executive Vice President and Chief Financial Officer USCB Financial Holdings, Inc. 2301 NW 87 thAvenue Doral, FL 33172 (305) 715-5200 (Name, Address, Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service) Copies to: James J. Barresi, Esq. Squire Patton Boggs (US) LLP 201 E. Fourth Street, Suite 1900 Cincinnati, OH 45202 Telephone: (513) 361-1200 Approximate date of commencement of proposed sale to the public:As soon as practicable after this registration statement becomes effective. If the securities being registered on this Form are being offered in connection with the formation of a holding company and there is compliance with General Instruction G, check the following box: ☐ If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “small