Company: SHPH
Filing Date: 2025-04-21
Form Type: DEFR14A
Source: 0001641172-25-005474
Chunk: 54

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-04-21
Form: DEFR14A
Chunk 54
---
,000,000 shares;

WHEREAS,
Section 18(a) of the Plan permits the Board to amend the Plan, subject, in the case of amendments requiring shareholder approval under
the rules of any securities exchange on which the shares may then be listed, to the approval by the Company’s shareholders of such
amendment;

WHEREAS,
this amendment shall be submitted to the Company’s shareholders for approval and, contingent on such approval, shall become effective
as of the date on which the Company’s shareholders approve such amendment (the “Effective Date”);

WHEREAS,
if the Company’s shareholders fail to approve this amendment, the existing Plan shall continue in full force and effect;

NOW, THEREFORE, BE IT RESOLVED, pursuant to Section 18(a) of the Plan, provided the Company’s shareholders approve this amendment,
the Plan shall be amended as follows, effective as of the Effective Date:

| 1. | Section                                    
 3(a) is hereby amended to read as follows: |

“(a) Subject to the provisions
of Section 14 hereof, the maximum aggregate number of Shares that may be awarded and sold under the Plan (the “Share Authorization”)
shall be equal to the sum of (i) five million (5,000,000) Shares; plus (ii) three million (3,000,000) Shares, which is the number of
shares that were authorized for grant under the Plan as originally adopted. The Shares may be authorized, but unissued, or reacquired
Common Stock.”

| 2. | Except                                                                                 
 as specifically set forth herein, the terms of the Plan shall be and remain unchanged. |

<div align='center'>[Signature Page Follows]</div>

IN WITNESS THEREOF, the undersigned has executed this Amendment No. 1 to the Shuttle Pharmaceuticals Holdings, Inc. 2018 Equity Incentive Plan.

| By:    |                         |
| Name:  | Christopher             
 Cooper                  |
| Title: | Interim                 
 Chief Executive Officer |
| Date:  | _________________,      
 2025                    |