Company: TEM
Filing Date: 2025-08-08
Form Type: S-3ASR
Source: 0001193125-25-175993
Chunk: 84

Company: Tempus AI, Inc.
Filing Date: 2025-08-08
Form: S-3ASR
Chunk 84
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 of Attorney (included on the signature page hereto).                                                 |          |                           |         |           |             |      |     |                |
| 25.1*** |           | Statement of Eligibility of Trustee for Indenture under the Trust Indenture Act of 1939, as amended.       |          |                           |         |           |             |      |     |                |
| 107*    |           | Filing Fee Table                                                                                           |          |                           |         |           |             |      |     |                |

| * | Filed herewith. |

| ** | To be filed by amendment or by a report filed under the Exchange Act, and incorporated herein by reference, if 
 applicable.                                                                                                    |

| *** | To be filed, if applicable, in accordance with the requirements of Section 305(b)(2) of the Trust 
 Indenture Act of 1939, as amended, and Rule 5b-3 thereunder.                                      |

II-3

Item 17. Undertaking

(a) The undersigned registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

(i) to include any prospectus required by Section 10(a)(3) of the Securities Act;

(ii) to reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities
offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the
Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20% change in the maximum aggregate offering price set forth in the “Filing Fee Table” in the exhibit to the effective
registration statement; and

(iii) to include any material information with respect to the plan of distribution not previously disclosed
in the registration statement or any material change to such information in the registration statement;

provided, however, that
paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) do not