Company: SCLXW
Filing Date: 2025-10-28
Form Type: PRE 14A
Source: 0001193125-25-253884
Chunk: 0

Company: Scilex Holding Co
Filing Date: 2025-10-28
Form: PRE 14A
Chunk 0
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box:

| ☒ | Preliminary Proxy Statement |

| ☐ | Confidential, for Use of the Commission Only (as permitted by 
 Rule 14a-6(e)(2))                                             |

| ☐ | Definitive Proxy Statement |

| ☐ | Definitive Additional Materials |

| ☐ | Soliciting Material under §240.14a-12 |

SCILEX HOLDING COMPANY (Name of Registrant as Specified In Its Charter) N/A (Name of Person(s) Filing Proxy Statement, if other than the Registrant) Payment of Filing Fee (Check the appropriate box):

| ☒ | No fee required. |

| ☐ | Fee paid previously with preliminary materials. |

| ☐ | Fee computed on table in exhibit required by Item 25(b) per Exchange Act 
 Rules 14a-6(i)(1) and 0-11.                                              |

SCILEX HOLDING COMPANY 960 San Antonio Road Palo Alto, CA 94303 NOTICE OF SPECIAL MEETING OF STOCKHOLDERS To Be Held at 9:00 a.m. Pacific Time on Thursday, December 11, 2025 Dear Stockholders of Scilex Holding Company: We cordially invite you to attend a Special Meeting of Stockholders (the “Special Meeting”) of Scilex Holding Company, a Delaware corporation (the “Company”, “Scilex”, “we”, “us” or “our”), which will be held virtually on Thursday, December 11, 2025 at 9:00 a.m. Pacific Time via live audio webcast on the Internet at www.virtualshareholdermeeting.com/SCLX2025SM2for the following purpose, as more fully described in the accompanying proxy statement for the Special Meeting (the “Proxy Statement”):

| (1) | To approve the repricing of certain stock options issued under the Scilex Holding Company 2022 Equity Incentive                       
 Plan, as amended (the “2022 Plan”), that are held by eligible service providers of the Company (the “Option Repricing Proposal”); and |

| (2) | To approve the adjournment of