Company: NCNA
Filing Date: 2025-04-04
Form Type: DRS
Source: 0000950123-25-003335
Chunk: 100

Company: NuCana plc
Filing Date: 2025-04-04
Form: DRS
Chunk 100
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 provide you with different information. You should not assume that the information in this prospectus is accurate as of any date other than the date of this prospectus or the date of the documents incorporated by reference in this prospectus. As you read the above documents, you may find inconsistencies in information from one document to another. If you find inconsistencies between the documents and this prospectus, you should rely on the statements made in the most recent document. All information appearing in this prospectus is qualified in its entirety by the information and financial statements, including the notes thereto, contained in the documents incorporated by reference herein. We will provide you without charge, upon your written or oral request, a copy of any of the documents incorporated by reference in this prospectus, other than exhibits to such documents which are not specifically incorporated by reference into such documents. Please direct your written or telephone requests to NuCana plc, 3 Lochside Way, Edinburgh, EH12 9DT, United Kingdom. Our telephone number is +44 (0)131 357 111. You may also obtain information about us by visiting our website at https://www.nucana.com/. Except for the specific incorporated documents listed above, no information available on or through our website shall be deemed to be incorporated in this prospectus or the registration statement of which it forms a part. The SEC also maintains an internet site that contains reports, proxy and information statements, and other information regarding issuers that file electronically with the SEC (http://www.sec.gov). 71

Confidential Treatment Requested by Nucana plc

Pursuant to 17 C.F.R. Section 200.83

Up to American Depositary Shares Representing

Ordinary Shares

Up to Series A Warrants to Purchase up to American Depositary Shares Representing up to Ordinary Shares

Up to Series B Warrants to Purchase up to American Depositary Shares Representing up to Ordinary Shares

Up to Pre-FundedWarrants to Purchase American Depositary Shares Representing Ordinary Shares

Up to American Depositary Shares Underlying the Pre-FundedWarrants, Series A Warrants and Series B Warrants Representing up to Ordinary Shares

PRELIMINARY PROSPECTUS

, 2025

LAIDLAW & COMPANY (UK) LTD.

Confidential Treatment Requested by Nucana plc Pursuant to 17 C.F.R. Section 200.83 Part II INFORMATION NOT REQUIRED IN THE PROSPECTUS

| Item 6. | Indemnification