Company: RVRC
Filing Date: 2025-08-13
Form Type: S-1/A
Source: 0001213900-25-075747
Chunk: 9

Company: Revium Rx.
Filing Date: 2025-08-13
Form: S-1/A
Chunk 9
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infection occurring in individuals with neutropenia (abnormally low levels of neutrophils), commonly seen in immunocompromised patients
such as those undergoing chemotherapy.

“PEGylated nano-liposomes” are
nano-liposomes modified with polyethylene glycol (PEG), a polymer used to improve circulation time in the bloodstream, reduce immunogenicity,
and enhance drug accumulation in target tissues.

“Phagocytic Cells” are Immune
cells (such as macrophages and neutrophils) that engulf and digest pathogens and cellular debris.

“Pharmacokinetics” is the study
of how a drug is absorbed, distributed, metabolized, and eliminated by the body over time.

“Pharmacokinetic Profile” is a
characterization of the drug’s behavior in the body over time, typically including data on absorption, peak concentration, half-life,
metabolism, and excretion.

“PEGylated Liposomal Delivery”
A drug delivery system in which the active compound is encapsulated in liposomes (spherical lipid-based carriers) that are coated with
polyethylene glycol (PEG). PEGylation increases the circulation time of the liposomes in the bloodstream by reducing immune system recognition
and clearance, thereby enhancing drug stability, bioavailability, and targeted delivery to diseased tissues such as tumors or infection
sites.

“Reticuloendothelial System (RES) represents
a network of immune cells, primarily in the liver, spleen, and lymph nodes, that filters pathogens and foreign particles from the blood,
often responsible for clearing nanoparticles and liposomal drugs.

“Tumor Microenvironment (TME)”
are the complex environment surrounding a tumor, including blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular
matrix, all of which influence tumor growth and drug response.

“VRE (Vancomycin-Resistant Enterococcus)”
refers to strains of Enterococcus bacteria that are resistant to vancomycin, an antibiotic often used as a last resort for treating
severe infections. VRE typically affects hospitalized patients, particularly those with weakened immune systems, and can lead to infections
in the urinary tract, bloodstream, or wounds.

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PROSPECTUS SUMMARY</div>

This summary provides an overview of certain information contained elsewhere in this Prospectus and does not contain all of the information that you should consider or that may be important to you. Before making an investment decision, you should read the