Company: TELO
Filing Date: 2025-02-04
Form Type: 10-K
Source: 0001493152-25-004872
Chunk: 275

Company: Telomir Pharmaceuticals, Inc.
Filing Date: 2025-02-04
Form: 10-K
Item: Item 1
Chunk 275
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metal overload, particularly of iron and copper, which are known to accelerate oxidative stress and contribute to telomere attrition.
By modulating ion levels and reducing oxidative damage, Telomir-1 may help preserve telomere integrity, restore cellular homeostasis,
and enhance overall cell resilience, potentially slowing down age-related degeneration. Additionally, by reversing oxidative stress, Telomir-1
may help mitigate the severity of viral infections such as bird flu by strengthening cellular defense mechanisms and improving immune
system function, potentially reducing disease progression and severity.

4

Our
focus is on addressing the effects of iron and copper overload while emphasizing the protective role of zinc. Excess iron can cause serious
health problems, such as liver fibrosis, liver failure, heart issues, and endocrine dysfunction. It is also linked to type 2 diabetes
mellitus (T2DM), as it disrupts insulin secretion, increases insulin resistance, and affects glucose production in the liver. In the
retina, iron buildup leads to oxidative stress and damage, contributing to Age-related Macular Degeneration (AMD).

Copper,
while essential for many physiological processes, becomes harmful when present in excess. High levels of copper increase oxidative stress,
damage retinal cells, and disrupt mitochondrial energy production, which can result in cell death and tissue degeneration. Copper overload
is particularly significant in Wilson’s disease, a rare genetic disorder that causes toxic copper accumulation in vital organs
like the liver and brain, leading to severe health complications.

In
contrast, zinc plays a protective role by reducing oxidative stress, regulating iron and copper levels, and restoring balance in cases
of imbalance or deficiency. This highlights zinc’s critical role in maintaining physiological health and equilibrium.

Our
objective is to investigate the molecular mechanisms of action of Telomir-1 through various biochemical methods. Additionally, we utilize
a range of animal models to evaluate the drug’s therapeutic potential and activity. As our research advances and our understanding
deepens, we may consider exploring alternative indications or adjusting our focus based on emerging insights or evolving circumstances.

Telomir-1
is currently undergoing preclinical investigation, with the goal of submitting an Investigational New Drug (IND) application and an Investigational
New Animal Drug (INAD) application to the FDA. If accepted, these submissions would enable progression to human and animal clinical trials.
Our research focuses on Telomir-1’s potential to interrupt, regulate, and prevent inflammatory pathways and enzymatic intracellular
processes responsible