Company: DNLI
Filing Date: 2025-02-27
Form Type: S-8
Source: 0001714899-25-000068
Chunk: 7

Company: Denali Therapeutics Inc.
Filing Date: 2025-02-27
Form: S-8
Chunk 7
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 Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on the 27th day of February 2025.

| DENALI THERAPEUTICS INC. |     |                                       |
| By:                      |     | /s/ Ryan J. Watts                     |
|                          |     | Ryan J. Watts, Ph.D.                  |
|                          |     | President and Chief Executive Officer |

### POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS , that each person whose signature appears below hereby constitutes and appoints Ryan J. Watts, Ph.D. and Alexander O. Schuth, M.D., and each of them, as such individual's true and lawful attorney-in-fact and agent with full power of substitution, for such individual in any and all capacities, to sign any and all amendments to this registration statement on Form S-8 (including post-effective amendments), and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorney-in-fact, proxy and agent full power and authority to do and perform each and every act and thing requisite and necessary to be done in connection therewith, as fully for all intents and purposes as such individual might or could do in person, hereby ratifying and confirming all that said attorney-in-fact, proxy and agent, or the individual's substitute, may lawfully do or cause to be done by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this registration statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.

Pursuant to the requirements of the Securities Act of 1933, this registration statement on Form S-8 has been signed by the following persons in the capacities and on the dates indicated.

| Signature                   
 /s/ Ryan J. Watts           |     | Title                                           
 President, Chief Executive Officer and Director 
 (Principal Executive Officer)                   |     | Date              
 February 27, 2025 |
|:----------------------------|:----|:------------------------------------------------|:----|:------------------|
| Ryan J. Watts, Ph.D.        |     |                                                 |     |                   |
| /s/ Alexander O. Schuth     |     | Chief Operating and Financial Officer           
 (Principal Financial and Accounting Officer)