Company: REVB
Filing Date: 2025-05-20
Form Type: S-1
Source: 0001213900-25-045828
Chunk: 102

Company: REVELATION BIOSCIENCES, INC.
Filing Date: 2025-05-20
Form: S-1
Chunk 102
---
 serious cases, dialysis may be needed to help replace kidney function until kidneys can recover. The main treatment is to address what is causing the acute kidney injury. Prevention and Treatment of Chronic Kidney Disease In April 2021, The FDA approved the use of Farxiga (Dapagliflozin) to reduce the risk of kidney function decline, kidney failure, cardiovascular death and hospitalization for heart failure in adults who are at risk of disease progression. Farxiga was originally approved in 2014 for diabetic control in adults in addition to diet and exercise. In addition to the approved drug, other treatments include lifestyle changes to control health and weight, medications to control associated diseases such as high blood pressure or high cholesterol and for later stages, filtering the blood with a machine known as dialysis. Avoiding conditions or exposures that can harm the kidneys like certain medications or kidney infections is also beneficial. Still, at this time, there is a significant unmet need for therapies that slow disease progression and improve outcomes of patients with chronic kidney disease. Prevention of Post Surgical Infection There are no approved therapies currently available for the prevention of infection outside of pre- and post-surgical administration of antibiotics and commonly recommended procedures for the preventing the transmission of bacteria including hand washing, mask wearing, and cleaning the surgical site pre- and post-surgery. In the case of antibiotic pretreatment, the typical course of treatment may require an initial empiric broad-spectrum antibiotic, later targeted to an organism if detected, with consideration for the presence of multidrug resistant pathogens, specifically MRSA. Antibiotic resistance has become a major consideration in the need for pretreatment of yet-to-be diagnosed infections, as the number of antibiotic resistant strains have increased, and the over prescription of antibiotics further contributes to resistance. Prevention of Post Burn Infection For smaller burn wounds (e.g., those not requiring hospitalization), the wound can be cleaned out with soap and water, significantly reducing the likelihood of any significant infection. The current standard of care for severe burn incorporates aggressive fluid resuscitation, alleviation of the hypermetabolic response, adequate and effective surgical grafting and coverage of burn wounds, pulmonary hygiene and ventilation, nutritional support, and infection control measures. It is common practice to treat all burn wounds with topical antimicrobial ointment to reduce infection. While the use of topical antimicrobials is common practice for burn wounds, it is not clear if the topical antimicrobials prevent infection or simply select out more resistant organisms. More importantly, multiple studies have