Company: CERO
Filing Date: 2025-07-28
Form Type: S-8
Source: 0001213900-25-068283
Chunk: 0

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-07-28
Form: S-8
Chunk 0
---
<div align='center'>As filed with the Securities and Exchange Commission on July 28, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT

Under

The Securities Act of 1933

CERO THERAPEUTICS HOLDINGS, INC.

(Exact name of registrant as specified in its charter)</div>

| Delaware                        |     | 81-4182129            |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -I.R.S. Employer      
 Identification Number |

<div align='center'>201 Haskins Way, Suite 230

South San Francisco, CA 94080

(215) 731-9450

(Address of Principal Executive Offices)

CERo Therapeutics Holdings, Inc. 2024 Equity Incentive Plan

CERo Therapeutics Holdings, Inc. 2024 Employee Stock Purchase Plan

(Full Title of the Plans)

Chris Ehrlich

Chief Executive Officer

CERo Therapeutics Holdings, Inc.

201 Haskins Way, Suite 230

South San Francisco, CA 94080

Telephone: (215) 731-9450

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copies to:

Stephen M. Davis

Jeffrey A. Letalien

Goodwin Procter LLP

The New York Times Building

620 Eighth Avenue

New York, New York 10018

(212) 813-8800</div>

Indicate by check mark whether the registrant is a large accelerated
filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of
“large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth
company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer | ☐ | Accelerated filer         | ☐ |
| Non-accelerated filer   | ☒ | Smaller reporting company | ☒ |
|                         |   | Emerging growth company   | ☒ |

If an emerging growth company, indicate by check mark if the registrant
has elected not to use the extended transition period for complying with any new or revised