Company: SCLXW
Filing Date: 2025-12-29
Form Type: 424B3
Source: 0001193125-25-335429
Chunk: 147

Company: Scilex Holding Co
Filing Date: 2025-12-29
Form: 424B3
Chunk 147
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 rules, we had 60 calendar days from receipt of such notice, or until January 20, 2025, to submit a plan to regain compliance with the Listing Rule. We regained compliance with Listing Rule 5250(c)(1) by filing the Q3 Form 10-Qon January 17, 2025. If, in the future, we are unable to maintain compliance with Nasdaq Listing Rules, Nasdaq could determine to delist our securities from trading on its exchange and if we are then unable to obtain listing on another national securities exchange, some or all of the following may occur, each of which could have a material adverse effect on our stockholders:

| • |     | causing our shares of Common Stock to be transferred to a more limited market than Nasdaq, which could affect the 
 market price, trading volume, liquidity and resale price of such shares;                                          |

| • |     | causing an event of default under our existing debt instruments; |

| • |     | reducing the number of investors, including institutional investors, willing to hold or acquire our Common Stock, 
 which could negatively impact our ability to raise equity;                                                        |

| • |     | decreasing the amount of news and analyst coverage relating to us; |

| • |     | reducing the availability of information concerning the trading prices and volume of our Common Stock |

| • |     | limiting our ability to issue additional securities, obtain additional financing or pursue strategic 
 restructuring, refinancing or other transactions; and                                                |

| • |     | impacting our reputation and, as a consequence, our business and operations. |

We completed a reverse stock split of our shares of common stock, which may reduce and may limit the market trading liquidity of the shares due to the reduced number of shares outstanding and may further decrease of total capitalization. On March 20, 2025, we held a special meeting at which our stockholders approved a reverse stock split at various ratios, after which our Board approved the Reverse Stock Split at a ratio of 1-for-35,which was effected on April 15, 2025. The liquidity of our Common Stock may be adversely affected by the Reverse Stock Split as a result of the reduced number of shares outstanding following the Reverse Stock Split. The Reverse Stock Split may be viewed negatively by the market and, consequently, could lead to a decrease in our overall market capitalization. If the per share market price of our Common Stock does not increase in proportion to the reverse stock split ratio, or following such increase does