Company: CERO
Filing Date: 2025-12-02
Form Type: DEFA14A
Source: 0001213900-25-117250
Chunk: 0

Company: CERO THERAPEUTICS HOLDINGS, INC.
Filing Date: 2025-12-02
Form: DEFA14A
Chunk 0
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<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No. )</div>

Filed by the Registrant ☒

Filed by a Party other than the Registrant ☐

Check the appropriate box:

| ☐ | Preliminary Proxy Statement                                                     |
| ☐ | Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) |
| ☐ | Definitive Proxy Statement                                                      |
| ☒ | Definitive Additional Materials                                                 |
| ☐ | Soliciting Material Under §240.14a-12                                           |

<div align='center'>CERo Therapeutics Holdings, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)</div>

Payment of Filing Fee (Check all boxes that apply):

| ☒ | No fee required.                                                                                     |
| ☐ | Fee paid previously with preliminary materials.                                                      |
| ☐ | Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11. |

<div align='center'>CERO THERAPEUTICS HOLDINGS, INC.

201 Haskins Way, Suite 230

South San Francisco, CA 94080

SUPPLEMENT
TO THE
PROXY STATEMENT
FOR
2025 SPECIAL MEETING OF STOCKHOLDERS
To Be Held On December 19, 2025, at 9:00 a.m. Pacific Time

The date of this Supplement is December 2, 2025</div>

This supplement (the “Supplement”) amends and supplements
the definitive proxy statement on Schedule 14A (the “Proxy Statement”) filed by CERo Therapeutics Holdings, Inc. (the “Company”)
with the U.S. Securities and Exchange Commission (the “SEC”) on November 28, 2025, in connection with the Company’s
2025 Special Meeting of Stockholders (the “Special Meeting”) to be held on December 19, 2025 at 9:00 a.m. Pacific Time.

The purpose of this Supplement is solely to make updates to clarify
disclosure in the Proxy Statement regarding the