Company: MIRM
Filing Date: 2025-04-14
Form Type: DEF 14A
Source: 0001759425-25-000022
Chunk: 2

Company: Mirum Pharmaceuticals, Inc.
Filing Date: 2025-04-14
Form: DEF 14A
Chunk 2
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| 3         |     | Approve, on an advisory basis, the compensation of the Company’s named executive officers, as disclosed herein (“Say on Pay Proposal”)                                                                                                                                               |     |   28 |     |                      |     | FOR                                          |

#### Mirum Pharmaceuticals2025 Proxy Statement3

### TABLE OF CONTENTS
| Questions and Answers About These Proxy Materials and Voting |

1. Why did I receive a notice regarding the availability of proxy materials on the internet?

Pursuant to rules adopted by the Securities and Exchange Commission (the “ SEC ”), we have elected to provide access to our proxy materials over the internet. Accordingly, we have sent you a Notice of Internet Availability of Proxy Materials (the “ Notice ”) because the Board of Directors (the “ Board ”) of Mirum Pharmaceuticals, Inc. (sometimes referred to as “ we ,” “ us ,” “ our ,” or the “ Company ”) is soliciting your proxy to vote at the 2025 Annual Meeting of Stockholders (the “Annual Meeting”), including at any one or more adjournments or postponements of the Annual Meeting. All stockholders will have the ability to access the proxy materials on the website referred to in the Notice or request to receive a printed set of the proxy materials. Instructions on how to access the proxy materials over the internet or to request a printed copy may be found in the Notice.

We intend to first mail the Notice and make this Proxy Statement and the form of proxy available on or about April 14, 2025 to all stockholders of record entitled to vote at the Annual Meeting.

2. Will I receive any other proxy materials by mail?

We may send you a proxy card, along with a second Notice, on or after April 24, 2025.

#### 3.

#### How do I attend the Annual Meeting?
Stockholders of record at the close of business as of April 3, 2025 (the “Record Date”) and holders of a valid proxy for the meeting may attend, vote and ask questions at the Annual Meeting in person at the Company’s headquarters located at 989 East Hillsdale Boulevard, Suite 300, Foster City, California 94404. If you are a beneficial owner of shares registered in the name of your broker, bank or other agent, follow the instructions from your broker or bank; you should contact the bank, broker or other institution where you hold your account well in advance of the meeting if you have questions