Company: BFRG
Filing Date: 2025-12-01
Form Type: 424B3
Source: 0001493152-25-025570
Chunk: 1

Company: BullFrog AI Holdings, Inc.
Filing Date: 2025-12-01
Form: 424B3
Chunk 1
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Nasdaq”) under the symbol “BFRG”. The last reported sale price of our common stock on Nasdaq on November 25, 2025 was $1.01 per share.

Investing in our common stock is highly speculative and involves a significant degree of risk. Please consider carefully the specific factors set forth under“ Risk Factors” beginning on page 11 of this prospectus and in our filings with the Securities and Exchange Commission.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this Prospectus is November
25, 2025.</div>

<div align='center'>TABLE OF CONTENTS</div>

|                                                      |     | Page |
| ABOUT THIS PROSPECTUS                                |     |    1 |
| PROSPECTUS SUMMARY                                   |     |    2 |
| THE OFFERING                                         |     |   10 |
| RISK FACTORS                                         |     |   11 |
| CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |   14 |
| THE LINCOLN PARK TRANSACTION                         |     |   15 |
| USE OF PROCEEDS                                      |     |   21 |
| DILUTION                                             |     |   22 |
| SELLING STOCKHOLDER                                  |     |   23 |
| PLAN OF DISTRIBUTION                                 |     |   25 |
| DESCRIPTION OF SECURITIES TO BE REGISTERED           |     |   27 |
| LEGAL MATTERS                                        |     |   30 |
| EXPERTS                                              |     |   30 |
| WHERE YOU CAN FIND MORE INFORMATION                  |     |   30 |
| INCORPORATION OF DOCUMENTS BY REFERENCE              |     |   30 |

| i |

<div align='center'>ABOUT THIS PROSPECTUS</div>

The registration statement we filed with the Securities and Exchange Commission (the “SEC”) includes exhibits that provide more detail of the matters discussed in this prospectus. You should read this prospectus, the related exhibits filed with the SEC, and the documents incorporated by reference herein before making your investment decision. You should rely only on the information provided in this prospectus or any amendment thereto. In addition, this prospectus contains summaries of certain provisions contained in some of the documents described herein, but reference is made to the actual documents