Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 7

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 7
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 based on information known to Comerica’s management as of the date of this prospectus supplement, the date of the accompanying prospectus and the date of the documents incorporated by reference, as applicable, and do not purport to speak as of any other date. Forward-looking statements may include descriptions of plans and objectives of Comerica’s management for future or past operations, products or services and forecasts of Comerica’s revenue, earnings or other measures of economic performance, including statements of profitability, business segments and subsidiaries as well as estimates of credit trends and global stability. Such statements reflect the view of Comerica’s management as of this date with respect to future events and are subject to risks and uncertainties. Should one or more of these risks materialize or should underlying beliefs or assumptions prove incorrect, Comerica’s actual results could differ materially from those discussed. Factors that could cause or contribute to such differences include:

| • |     | changes in customer behavior may adversely impact the Company’s business, financial condition and results of 
 operations;                                                                                                  |

| • |     | unfavorable developments concerning credit quality could adversely affect the Company’s financial results; |

| • |     | declines in the businesses or industries of the Company’s customers could cause increased credit losses or 
 decreased loan balances, which could adversely affect the Company;                                         |

| • |     | governmental monetary and fiscal policies may adversely affect the financial services industry, and therefore 
 impact the Company’s financial condition and results of operations;                                           |

| • |     | fluctuations in interest rates and their impact on deposit pricing could impact the Company’s net interest 
 income and balance sheet;                                                                                  |

| • |     | the Company must maintain adequate sources of funding and liquidity to meet regulatory expectations, support its 
 operations and fund outstanding liabilities;                                                                     |

| • |     | reduction in the Company’s credit ratings could adversely affect the Company and/or the holders of its 
 securities;                                                                                            |

| • |     | the soundness of other financial institutions could adversely affect the Company; |

| • |     | security risks, including denial of service attacks, hacking, social engineering attacks targeting the                                                                                                                                           
 Company’s colleagues, customers and partners, malware intrusion or data corruption attempts, and identity theft, could result in the disclosure of confidential information, adversely affect its business or reputation, and create significant 
 legal and financial exposure;                                                                                                                                                                                                                    |

| • |     | cybersecurity and data privacy are areas of heightened legislative and regulatory focus; |

| • |     | the Company’s operational or security