Company: TEM
Filing Date: 2025-08-27
Form Type: 424B7
Source: 0001193125-25-189854
Chunk: 14

Company: Tempus AI, Inc.
Filing Date: 2025-08-27
Form: 424B7
Chunk 14
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 us in making decisions with respect to the timing, manner and size of each sale. Such sales may be made on one or more exchanges, markets, trading facilities or in the over-the-countermarket or otherwise, at fixed prices, at prevailing market prices at the time of sale, at prices related to the prevailing market price, at varying prices determined at the time of sale or at negotiated prices. The selling stockholders may sell or otherwise dispose of their securities by one or more of, or a combination of, the following methods:

| • |     | through one or more underwriters in a public offering, pursuant to which underwriters may resell the shares in                                       
 one or more transactions, including in negotiated transactions at a fixed public offering price or at varying prices determined at the time of sale; |

| • |     | purchases by a broker-dealer as principal and resale by such broker-dealer for its own account pursuant to this 
 prospectus supplement;                                                                                          |

| • |     | ordinary brokerage transactions and transactions in which the broker solicits purchasers; |

| • |     | transactions in which the broker-dealer solicits purchasers on a best efforts basis; |

| • |     | block trades in which the broker-dealer so engaged will attempt to sell the shares as agent but may position and 
 resell a portion of the block as principal to facilitate the transaction;                                        |

| • |     | an over-the-counter distribution                         
 in accordance with the rules of the Nasdaq Stock Market; |

| • |     | through trading plans entered into by a selling stockholder pursuant to Rule                                                                                                                                      
 10b5-1 under the Exchange Act, that are in place at the time of an offering pursuant to this prospectus supplement that provide for periodic sales of its securities on the basis of parameters described in such 
 trading plans;                                                                                                                                                                                                    |

| • |     | short sales or through the settlement of short sales (including short sales “against the box”), 
 subject to compliance with the Securities Act and other applicable securities laws;             |

| • |     | distribution to employees, members, limited partners or stockholders of a selling stockholder; |

| • |     | through the writing or settlement of standardized or over-the-counter options, swaps or other hedging or derivative transactions, whether through an options exchange or otherwise; |

| • |     | in other ways not involving market makers or established trading markets, including direct sales to purchasers or 
 sales effected through agents;                                                                                    |

| • |     | by pledge