Company: CMA
Filing Date: 2025-08-05
Form Type: 424B5
Source: 0001193125-25-173600
Chunk: 76

Company: COMERICA INC
Filing Date: 2025-08-05
Form: 424B5
Chunk 76
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 subscription or other offer to purchase the depositary shares will be binding on us until received and accepted by us or any underwriter outside of Taiwan (the “Place of
Acceptance”), and the purchase/sale contract arising therefrom will be deemed a contract entered into in the Place of Acceptance.

S-51

LEGAL MATTERS

The validity of the depositary shares and shares of Series B Preferred Stock offered hereby and certain other legal matters relating to the
offering will be passed upon for us by Haynes and Boone, LLP, Dallas, Texas. Certain legal matters will be passed upon for the underwriters by Willkie Farr & Gallagher LLP, Chicago, Illinois.

EXPERTS

The consolidated financial statements of Comerica appearing in our Annual Report on Form 10-K for the
year ended December 31, 2024, and the effectiveness of Comerica’s internal control over financial reporting as of December 31, 2024, have been audited by Ernst & Young LLP, independent registered public accounting firm, as
set forth in their reports thereon, included therein, and incorporated herein by reference. Such consolidated financial statements are incorporated herein by reference in reliance upon such reports given on the authority of such firm as experts in
accounting and auditing.

S-52

PROSPECTUS

Comerica Incorporated

Common Stock

Preferred Stock

Depositary Shares

Debt Securities

Warrants to Purchase Common Stock, Preferred Stock and Debt Securities

Stock Purchase Contracts

Stock Purchase Units

The securities listed above may be offered and sold from time to time by Comerica, and also may be offered and sold, from time to time, by one or more selling
securityholders to be identified in the future. Comerica will provide the specific terms of these securities in supplements to this prospectus. You should read this prospectus and the applicable prospectus supplement carefully before you invest in
any of these securities.

Comerica’s common stock is traded on the New York Stock Exchange under the symbol “CMA.”

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

Investing in these securities involves risks. See “ Risk Factors” in this prospectus and in our Annual Report on Form 10-Kfor the year ended December 31, 2022, and in other documents that Comerica has subsequently filed with the Securities and Exchange Commission