Company: TEM
Filing Date: 2025-08-08
Form Type: S-3ASR
Source: 0001193125-25-175993
Chunk: 45

Company: Tempus AI, Inc.
Filing Date: 2025-08-08
Form: S-3ASR
Chunk 45
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 carefully the risks and uncertainties described in the section titled “ Risk Factors” on page 4 of this prospectus and contained in any applicable prospectus supplement and in any free writing prospectuses we have authorized for use in connection with a specific offering, and under similar headings in the documents that are incorporated by reference into this prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is August 8, 2025.

TABLE OF CONTENTS

|                                                   |     | Page |     |
| ABOUT THIS PROSPECTUS                             |     |      |   i |
| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     |      | iii |
| PROSPECTUS SUMMARY                                |     |      |   1 |
| RISK FACTORS                                      |     |      |   4 |
| USE OF PROCEEDS                                   |     |      |   5 |
| SELLING STOCKHOLDERS                              |     |      |   6 |
| PLAN OF DISTRIBUTION                              |     |      |   8 |
| LEGAL MATTERS                                     |     |      |  11 |
| EXPERTS                                           |     |      |  11 |
| WHERE YOU CAN FIND MORE INFORMATION               |     |      |  11 |
| INCORPORATION OF CERTAIN INFORMATION BY REFERENCE |     |      |  12 |

ABOUT THIS PROSPECTUS

This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and
Exchange Commission (the “SEC”) utilizing a “shelf” registration process as a “well-known seasoned issuer” as defined in Rule 405 under the Securities Act of 1933, as amended (the “Securities Act”). Under this
shelf registration process, the selling stockholders may offer shares of our Class A common stock in one or more offerings. There is no limit on the aggregate number of shares of Class A common stock that the selling stockholders may offer
pursuant to the registration statement of which this prospectus is a part.

The selling stockholders listed under the heading
“Selling Stockholders” in this prospectus may offer and sell up to 2,439,155 shares of our Class A common stock pursuant to this prospectus. In addition, from time to time, selling stockholders to