Company: GHRS
Filing Date: 2025-02-05
Form Type: 424B5
Source: 0001140361-25-003183
Chunk: 46

Company: GH Research PLC
Filing Date: 2025-02-05
Form: 424B5
Chunk 46
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us supplements will also describe the specific manner in which these securities will be offered and may also supplement, update or amend information contained in this prospectus. You should read this prospectus and any applicable prospectus supplement before you invest.

The securities covered by this prospectus may be offered through one or more underwriters, dealers and agents, or directly to purchasers. The names of any underwriters, dealers or agents, if any, the applicable commissions or discounts payable to them and the specific terms of the plan of distribution will be included in a supplement to this prospectus. For general information about the distribution of securities offered, please see “Plan of Distribution” beginning on page 36 .

Our ordinary shares are listed on the Nasdaq Global Market, or Nasdaq, under the symbol “GHRS”.

**We are an “emerging growth company” under the applicable Securities and Exchange Commission, or SEC, rules and have elected to comply with certain reduced public company reporting requirements for this prospectus and future filings.

Our business and investment in our securities involve significant risks. These risks are described under the caption “Risk Factors” beginning on page**

#### 5
**of this prospectus and, if applicable, any risk factors described in any applicable prospectus supplement and in our SEC filings that are incorporated by reference in this prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.**

<div align='center'>Prospectus dated March 17, 2023.</div>

TABLE OF CONTENTS

TABLE OF CONTENTS

|                                                           |     | Page |
| About this Prospectus                                     |     |    1 |
| Our Company                                               |     |    3 |
| Risk Factors                                              |     |    5 |
| Cautionary Statement Regarding Forward-Looking Statements |     |    6 |
| Use of Proceeds                                           |     |    7 |
| Description of Share Capital and Constitution             |     |    8 |
| Comparison of Irish Law and Delaware Law                  |     |   18 |
| Description of Debt Securities                            |     |   33 |
| Description of Warrants                                   |     |   33 |
| Description of Units                                      |     |   33 |
| Description of Subscription Rights                        |     |   33 |
| Forms of Securities                                       |     |   34 |
| Plan of Distribution                                      |     |