Company: SHPH
Filing Date: 2025-02-27
Form Type: 424B3
Source: 0001493152-25-008474
Chunk: 3

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-02-27
Form: 424B3
Chunk 3
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 ☒ | Smaller           
 reporting company | ☒ |
|                   |   | Emerging          
 growth company    | ☒ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☐

If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements. ☐

Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b). ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes ☐ No ☒

The aggregate market value of the registrant’s common stock, par value $0.00001 per share, held by non-affiliates of the registrant, as computed by reference to the June 30, 2024 closing price reported by Nasdaq, was approximately $4,100,953.

The number of shares outstanding of the registrant’s common stock on February 24, 2025, was 4,076,567.

<div align='center'>Shuttle Pharmaceuticals Holdings, Inc.

TABLE OF CONTENTS</div>

|            |                                                                                                              |     | Page 
  No. |
|            | PART I                                                                                                       |     |      |
| Item       
 1.         | Business                                                                                                     |     |    4 |
| Item       
 1A.        | Risk Factors                                                                                                 |     |   21 |
| Item       
 1B.        | Unresolved Staff Comments                                                                                    |     |   52 |
| Item       
 1C.        | Cybersecurity                                                                                                |     |   53 |
| Item       
 2.         | Properties                                                                                                   |     |