Company: NCNA
Filing Date: 2025-04-24
Form Type: F-1
Source: 0001193125-25-092131
Chunk: 98

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-1
Chunk 98
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 to U.K. capital gains tax on the disposal of a Warrant/Pre-Funded Warrant or an ADS, the current applicable rate is 24%.
For a U.K. Individual Holder who is subject to U.K. income tax at the basic rate and, after all allowable deductions, liable to U.K. capital gains tax on such disposal, the current applicable rate is 18%, save to the extent that any capital gains
exceed the unused basic rate tax band. In that case, the current rate applicable to the excess is 24%.

A U.K. Individual Holder who
ceases to be resident in the United Kingdom (or who fails to be regarded as resident in a territory outside the United Kingdom for the purposes of double taxation relief) for a period of less than five years and who disposes of his or her Warrants/Pre-Funded Warrants and/or ADSs during that period of temporary non-residence may be liable to U.K. capital gains tax on a chargeable gain accruing on such disposal
on his or her return to the United Kingdom (or upon ceasing to be regarded as resident outside the United Kingdom for the purposes of double taxation relief) (subject to available exemptions or reliefs).

Non-UnitedKingdom Holders. The paragraphs below relating to the liability of non-U.K. Holders to U.K. tax on chargeable gains assume that the company does not (and will not) derive 75% or more of its gross asset value from U.K. land.

An individual holder who is not a U.K. Holder will not be liable to U.K. capital gains tax on capital gains realized on the disposal of his or
her Warrants/Pre-Funded Warrants and/or ADSs unless such holder carries on (whether solely or in partnership) a trade, profession or vocation in the United Kingdom through a permanent establishment in the
United Kingdom to which the Warrants/Pre-Funded Warrants and/or ADSs are attributable. In these circumstances, such holder may, depending on his or her individual circumstances, be chargeable to U.K. capital
gains tax on chargeable gains arising from a disposal of his or her Warrants/Pre-Funded Warrants and/or ADSs.

A corporate holder of Warrants/Pre-Funded Warrants and/or ADSs that is not a U.K. Holder will not be liable for U.K. corporation tax on chargeable gains realized on the disposal of its
Warrants/Pre-Funded Warrants