Company: TEM
Filing Date: 2025-03-07
Form Type: 424B3
Source: 0001193125-25-049935
Chunk: 42

Company: Tempus AI, Inc.
Filing Date: 2025-03-07
Form: 424B3
Chunk 42
---
Us will vest for each full three months of continuous service elapsed from the first 
 anniversary of the vesting start date, subject to the participant’s continuous service.                                                                                                                                                          |

| • |     | If the Liquidity Event Date occurred after the second anniversary of the vesting start date, then 1/16th of                                                                                                                                           
 the RSUs will vest on the Liquidity Event Date for each full three months that has elapsed since the vesting start date and thereafter an additional 1/16th of the RSUs will vest for each full three months that occurs from the vesting start date, 
 subject to the participant’s continuous service.                                                                                                                                                                                                      |

We have also granted PSUs, which included both a Liquidity Event vesting requirement and a performance-vesting condition. Like the RSU awards, the Liquidity Event requirement of the PSUs was satisfied on the effective date of the IPO. The performance-vesting condition of the PSUs, which was based on the company’s total enterprise valuation being at least $6 billion as of the Liquidity Event Date, was removed by our board of directors in July 2023. Accordingly, the PSUs are treated as RSUs as the terms of such PSUs are consistent with those of our outstanding RSUs. Transferability.Awards are generally not transferable other than by will or the laws of descent and distribution. The board, in its discretion, may allow certain transfers of options as set forth in an award agreement and subject to certain securities law restrictions. Adjustments. In the event of certain corporate events or changes in our capitalization, the board will make adjustments to one or more of the number and kind of shares that may be delivered under the 2015 Plan or 27

covered by each outstanding award, the ISO share reserve under the 2015 Plan and the exercise or purchase price per share of outstanding awards in order to prevent dilution or enlargement of the participants’ rights under the 2015 Plan. Change in Control. Upon a change in control, without the consent of any participant, the board may provide for any one or more of the following:

| • |     | accelerate the time of exercisability, vesting and/or settlement of an award, |

| • |     | the assumption or substitution of outstanding award by a surviving, continuing, successor or purchasing 
 corporation or other business entity (or any parent thereof); or                                        |

| • |     | awards to be cancelled, to the extent not vested or exercised before the transaction,