Company: SMNR
Filing Date: 2025-08-08
Form Type: S-4/A
Source: 0001193125-25-177097
Chunk: 505

Company: Semnur Pharmaceuticals, Inc.
Filing Date: 2025-08-08
Form: S-4/A
Chunk 505
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 treatment-by-week interaction. |

| (3) | The analysis uses an ANCOVA model with fixed effects for treatment (SP-102 or placebo), site, Pain Catastrophizing Scale group (<30 or ≥30), and baseline score. |

ANCOVA: analysis of covariance; ANOVA: analysis of variance; BPI-SF:Brief Pain Inventory – Short Form; CI: confidence interval; ITT: intent-to-treat(randomized population); LSM: least-squares mean; MMRM: mixed model for repeated measures; NPRS: numeric pain rating scale; REML: restricted maximum likelihood; SE: standard error Patient Global Impression of Change (PGIC) and Clinical Global Impression of Change (CGIC) – ITT Population

|                                                                                                    |     | SP-102            
 N=202             |     | Placebo    
 N=199      |
| PGIC Responders (number of patients who responded with “very much improved” or “much improved”)(1) |     | 71 (35.1%)        |     | 39 (19.6%) |
| Chi-Square                                                                                         |     | P<0.001           |     |            |
| Logistic regression (odds ratio [95% CI])(2)                                                       |     | 2.25 (1.42, 3.54) 
 P<0.001           |     |            |
| CGIC Responders (number of patients assessed as “very much improved” or “much improved”)(1)        |     | 76 (37.6%)        |     | 39 (19.6%) |
| Chi-Square                                                                                         |     | P<0.001           |     |            |
| Logistic regression (odds ratio [95% CI])(2)                                                       |     | 2.49 (1.58, 3.91) 
 P<0.001           |     |            |

302

| (1) | 7-point scale rating patient’s overall improvement. Patient change is rated from “very much improved”, “much improved”, “minimally improved”, “no change”, “minimally worse”, “much worse” or “very much worse”. |

| (2) | Logistic regression models with treatment (SP-102 or placebo), site, and Pain Catastrophizing Scale group (<30 or ≥30) as factors. |

CI: confidence interval; ITT: intent-to-treat(random