Company: SHPH
Filing Date: 2025-03-05
Form Type: S-1/A
Source: 0001493152-25-009106
Chunk: 66

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-03-05
Form: S-1/A
Chunk 66
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 the securities subject to this offering.

Subject to certain conditions, we have agreed to sell to the Underwriter such securities listed next to their names in the below table at the public offering price less the underwriting discounts and commissions set forth on the cover page of this prospectus.

We have agreed to indemnify the Underwriter against specified liabilities, including liabilities under the Securities Act, and to contribute to payments the Underwriter may be required to make in respect thereof.

| Underwriter            |     | Number    
 of Shares 
 of Common 
 Stock     |            |
| WestPark Capital, Inc. |     |           | 10,000,000 |
| Total                  |     |           | 10,000,000 |

Subject to the terms and conditions set
forth under the underwriting agreement, the underwriter has agreed to purchase 10,000,000 shares of common stock or Pre-Funded
Warrants offered by this prospectus.

The underwriter is offering the shares of common
stock, and Pre-Funded Warrants in lieu thereof, subject to various conditions and may reject all or part of any order. The Underwriter
has advised us that they propose initially to offer the shares of common stock to the public at the public offering price set forth on
the cover page of this prospectus and to dealers at a price less a concession not in excess of $[ ] per share of common stock,
or Pre-Funded Warrant in lieu thereof. After the shares of common stock and Pre-Funded Warrants are released for sale to the public,
the Underwriter may change the offering price, the concession, and other selling terms at various times.

Discounts and Commissions

The following table provides information regarding
the amount of the discounts and commissions to be paid to the Underwriter by us, before expenses.

|                                             |     | Per Share or per Pre-Funded Warrant |     | Total |
|:--------------------------------------------|:----|:------------------------------------|:----|:------|
| Public offering price                       |     | $                                   |     | $     |
| Underwriting discounts and commissions (4%) |     | $                                   |     | $     |
| Proceeds, before expenses, to us            |     | $                                   |     | $     |

The Company has agreed to pay
the Underwriter for: (i) reasonable aggregate expense allowance up to $80,000, and (ii) a non-accountable expense allowance equal to one percent (1%) of the gross proceeds received by