Company: XXII
Filing Date: 2025-11-04
Form Type: 424B5
Source: 0001493152-25-020754
Chunk: 4

Company: 22nd Century Group, Inc.
Filing Date: 2025-11-04
Form: 424B5
Chunk 4
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,” “us,” “our,” and “ours” refer to 22nd Century Group, Inc. and its subsidiaries where the context so requires, unless otherwise indicated or the context otherwise requires.

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<div align='center'>“Forward-Looking Information”</div>

This prospectus supplement and the information incorporated by reference in this prospectus supplement include “forward-looking statements” within the meaning of Section 27A of the Securities Act and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). All statements, other than statements of historical fact, included or incorporated by reference herein regarding our expectations, beliefs, plans, objectives, prospects, financial condition, assumptions or future events are forward-looking statements. You can identify these statements by words such as “aim,” “anticipate,” “assume,” “believe,” “could,” “due,” “estimate,” “expect,” “goal,” “intend,” “may,” “objective,” “plan,” “potential,” “positioned,” “predict,” “should,” “target,” “will,” “would” and other similar expressions that are predictions of or indicate future events and future trends. These forward-looking statements are based on current expectations, estimates, forecasts and projections about our business and the industry in which we operate and our management’s beliefs and assumptions. These statements are not guarantees of future performance or development and involve known and unknown risks, uncertainties and other factors that are in some cases beyond our control. All forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from those that we expected, including the following summary of risk factors:

| ● | We                                                                                                                                
 have had a history of losses and negative cash flows, and we may be unable to achieve and sustain profitability and positive cash 
 flows from operations.                                                                                                            |

| ● | Our                                     
 ability to continue as a going concern. |

| ● | Our                                                                  
 ability to maintain compliance with the NASDAQ listing requirements. |

| ● | Our                                                                                                                                
 competitors generally have, and any future competitors may have, greater financial resources and name recognition than we do, and  
 they may therefore develop products or other technologies similar or superior to ours, or otherwise compete more successfully than 
 we do.                                                                                                                             |

| ● | Our                                                                                                                                   
 research and development process may not develop marketable products, which would result in loss of our investment into such process. |

| ● | The                                                                                                                                  
 failure of our information systems to function as