Company: SCLXW
Filing Date: 2025-08-04
Form Type: S-1
Source: 0001193125-25-172703
Chunk: 624

Company: Scilex Holding Co
Filing Date: 2025-08-04
Form: S-1
Chunk 624
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 a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue. II-16

SIGNATURES Pursuant to the requirements of the Securities Act, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Palo Alto, State of California, on the 4th day of August 2025.

| Scilex Holding Company |     |                                              |
| By:                    |     | /s/ Jaisim Shah                              |
|                        |     | Name: Jaisim Shah                            |
|                        |     | Title: Chief Executive Officer and President |

Each person whose signature appears below constitutes and appoints each of Jaisim Shah and Stephen Ma, acting alone or together with another attorney-in-fact, as his true and lawful attorney-in-fact and agent, with full power of substitution and resubstitution, for such person and in his name, place and stead, in any and all capacities, to sign any or all further amendments (including post-effective amendments) to this registration statement (and any additional registration statement related hereto permitted by Rule 462(b) promulgated under the Securities Act of 1933, as amended (and all further amendments, including post-effective amendments thereto)), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-fact and agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act, this registration statement has been signed by the following persons in the capacities and on the dates indicated.

| Signature                                           
 /s/ Jaisim Shah Jaisim Shah                         
 /s/ Stephen Ma Stephen Ma                           |     | Title                                                                         
 Chief Executive Officer, President and Director (Principal Executive Officer) 
 Chief Financial Officer (Principal Financial and Accounting Officer)          |     | Date           
 August 4, 2025 
 August 4, 2025 |
|:----------------------------------------------------|:----