Company: SXTPW
Filing Date: 2025-09-05
Form Type: 424B5
Source: 0001213900-25-085050
Chunk: 4

Company: 60 DEGREES PHARMACEUTICALS, INC.
Filing Date: 2025-09-05
Form: 424B5
Chunk 4
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 may obtain copies of those documents as described
in this prospectus supplement under the heading “Where You Can Find More Information.”

<div align='center'>S-ii

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS</div>

This prospectus supplement, the accompanying base prospectus and the
documents incorporated herein by reference contain forward-looking statements (including within the meaning of Section 21E of the United
States Securities Exchange Act of 1934, as amended, and Section 27A of the United States Securities Act of 1933, as amended), contain
forward-looking statements. These statements relate to future events or to our future financial performance and involve known and unknown
risks, uncertainties and other factors that may cause our actual results to be materially different from any future results expressed
or implied by the forward-looking statements. In some cases, you can identify forward-looking statements by the use of words such as “believe,”
“anticipate,” “intend,” “plan,” “estimate,” “may,” “could,” “anticipate,”
“predict,” or “expect” and similar expressions. You should not place undue reliance on forward-looking statements
since they involve known and unknown risks, uncertainties and other factors that are, in many cases, beyond our control. Forward-looking
statements are not guarantees of future performance. Actual events or results may differ materially from those discussed in the forward-looking
statements as a result of various factors. Except as required by applicable law, we do not undertake any obligation to publicly update
any forward-looking statements, whether as a result of new information, future developments or otherwise.

Important factors that could
cause actual results to differ materially from those reflected in our forward-looking statements include, among others:

| ● | Our ability to effectively operate our business segments; |

| ● | Our ability to manage our research, development, expansion, 
 growth and operating expenses;                              |

| ● | Our ability to evaluate and measure our business, prospects 
 and performance metrics;                                    |

| ● | Our ability to compete, directly and indirectly, and succeed 
 in a highly competitive and evolving industry;               |

| ● | Our ability to respond and adapt to changes in technology 
 and customer behavior;                                    |

| ● | Our ability to protect our intellectual property and to develop, 
 maintain and enhance a strong brand; and                         |

| ● | other factors (including the risks contained in the section of this                                                        
 prospectus supplement and the accompanying base prospectus titled “Risk