Company: SCLXW
Filing Date: 2025-07-23
Form Type: 424B3
Source: 0001193125-25-163077
Chunk: 158

Company: Scilex Holding Co
Filing Date: 2025-07-23
Form: 424B3
Chunk 158
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IN WITNESS WHEREOF, each of the undersigned have caused their respective signature page to this Agreement to be duly executed as of the date first written above.

| BPY LIMITED                  |     |                 |
| By:                          |     | /s/ James Keyes |
| Name:                        |     | James Keyes     |
| Title:                       |     | Director        |
| Address:                     |     |                 |
| Wessex House                 |     |                 |
| 3rd Floor                    |     |                 |
| Hamilton, HM 12              |     |                 |
| Bermuda                      |     |                 |
| Attention: Peter Poole       |     |                 |
| Email:                       |     |                 |
| jfenttiman@murchinsonltd.com |     |                 |
| pzogola@murchinsonltd.com    |     |                 |

[ Signature Page to Exchange Agreement]

IN WITNESS WHEREOF, each of the undersigned have caused their respective signature page to this Agreement to be duly executed as of the date first written above.

| SCILEX HOLDING COMPANY                       |     |                 |
| By:                                          |     | /s/ Jaisim Shah |
| Name: Jaisim Shah                            |     |                 |
| Title: Chief Executive Officer and President |     |                 |

[ Signature Page to Exchange Agreement]

Annex A

Form of New Tranche B Warrant

Exhibit 10.5

WARRANT EXCHANGE AGREEMENT

This W ARRANT E XCHANGEA GREEMENT (the
“Agreement”), dated as of July 22, 2025, is by and between Scilex Holding Company, a Delaware corporation with offices located at 960 San Antonio Road, Palo Alto, CA 94303 (the “Company”) and the undersigned (the
“Holder”). Capitalized terms used but not defined herein are used with the respective meanings assigned to them in the Tranche B SPA (as defined below).

WHEREAS, prior to the date hereof, the Company issued, severally, certain promissory notes (the “Tranche B Notes”) and warrants to purchase shares of common stock, par value $0.0001 per share, of the Company (“Common Stock”) in the initial aggregate amount of 7,500,000 shares (not taking into account the Company’s
subsequent 1-for-35 reverse stock split, which became effective on April 15, 202