Company: TEM
Filing Date: 2025-08-08
Form Type: S-3ASR
Source: 0001193125-25-175993
Chunk: 40

Company: Tempus AI, Inc.
Filing Date: 2025-08-08
Form: S-3ASR
Chunk 40
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 sell the securities to or through one or more underwriters or dealers (acting as principal or agent), through agents, or directly to one or more purchasers. We may distribute securities from time to time in one or more transactions:

| • |     | at a fixed price or prices, which may be changed; |

| • |     | at market prices prevailing at the time of sale; |

| • |     | at prices related to such prevailing market prices; or |

| • |     | at negotiated prices. |

We may also sell equity securities covered by this registration statement in an “at the market offering” as defined in Rule 415(a)(4) under the Securities Act. Such offering may be made into an existing trading market for such securities in transactions at other than a fixed price, either:

| • |     | on or through the facilities of the Nasdaq Global Select Market or any other securities exchange or quotation or                                             
 trading service on which such securities may be listed, quoted or traded at the time of sale; and/or at market prices prevailing at the time of sale; and/or |

| • |     | to or through a market maker other than on the Nasdaq Global Select Market or such other securities exchanges or 
 quotation or trading services.                                                                                   |

Such at-the-marketofferings, if any, may be conducted by underwriters acting as principal or agent. A prospectus supplement or supplements (and any related free writing prospectus that we may authorize to be provided to you) will describe the terms of the offering of the securities, including, to the extent applicable:

| • |     | the name or names of the underwriters, dealers or agents, if any; |

| • |     | the purchase price of the securities or other consideration therefor, and the proceeds, we will receive from the 
 sale;                                                                                                            |

| • |     | any over-allotment or other options under which underwriters may purchase additional securities from us; |

| • |     | any agency fees or underwriting discounts and other items constituting agents’ or underwriters’ 
 compensation;                                                                                   |

| • |     | any public offering price; |

| • |     | any discounts or concessions allowed or reallowed or paid to dealers; and |

| • |     | any securities exchange or market on which the securities may be listed. |

Only underwriters named in the prospectus supplement will be underwriters of the securities offered by the prospectus supplement. Dealers and agents participating in the distribution of