Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 2

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 2
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 to Purchase up to 12,497,768 American Depositary Shares Representing up to 312,444,200 Ordinary Shares

Series B Warrants to Purchase up to 12,497,768 American Depositary Shares Representing up to 312,444,200 Ordinary Shares

Pre-FundedWarrants to Purchase 12,497,768 American Depositary Shares Representing up to 312,444,200 Ordinary Shares

Up to 559,275,129 American Depositary Shares Underlying the Series A Warrants, the Series B Warrants (which Series B Warrants contain a “zero exercise price” option) and the Pre-Funded Warrants Representing up to 13,981,878,225 Ordinary Shares

This is a reasonable best efforts offering of up to 12,497,768 American Depositary Shares, or ADSs, together with Series A ADS purchase
warrants to purchase up to 12,497,768 ADSs, or the Series A Warrants, and Series B ADS purchase warrants to purchase up to 12,497,768 ADSs, or the Series B Warrants, and together with the Series A Warrants, the Warrants. Each ADS or a Pre-Funded Warrant (as defined below) in lieu thereof, is being sold together with a Series A Warrant to purchase one ADS and a Series B Warrant to purchase one ADS. The ADSs and Warrants are immediately separable
and will be issued separately in this offering, but must be purchased together in this offering. The assumed combined public offering price for each ADS and accompanying Warrants is $0.5601, which was the closing price of our ADSs on The Nasdaq
Capital Market on April 28, 2025. Each Series A Warrant will have an exercise price of equal to 125% of the combined public offering price, and will be exercisable beginning on the date on which each warrant is issued, or the Initial Exercise
Date. Each Series B Warrant will have an exercise price equal to 250% of the combined public offering price, and will be exercisable beginning on the Initial Exercise Date. The Series A Warrants will expire on the five-year anniversary of the
Initial Exercise Date and the Series B Warrants will expire on the two and one-half anniversary of the Initial Exercise Date.

Additionally, the Warrants contain exercise price adjustments, adjustments to increase the number of ADSs “issuable” upon exercise,
and in the case of the Series B