Company: WHWK
Filing Date: 2025-03-28
Form Type: S-8
Source: 0001193125-25-067200
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Company: Whitehawk Therapeutics, Inc.
Filing Date: 2025-03-28
Form: S-8
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As filed with the Securities and Exchange Commission on March 28, 2025 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT Under The Securities Act of 1933 WHITEHAWK THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter)

| Delaware                        |     | 61-1547850         |
| (State or other jurisdiction of 
 incorporation or organization)  |     | -I.R.S. Employer   
 Identification No. |

2 Headquarters Plaza East Building, 11th Floor Morristown, NJ 07960 (Address of Principal Executive Offices, including zip code) Amended and Restated 2021 Equity Incentive Plan 2021 Employee Stock Purchase Plan (Full title of the plan) David J. Lennon Chief Executive Officer 2 Headquarters Plaza East Building, 11th Floor Morristown, NJ 07960 (551) 321-2234 (Name, address and telephone number, including area code, of agent for service) Copies to: Dan Koeppen, Esq. Robert L. Wernli, Jr., Esq. Wilson Sonsini Goodrich & Rosati, P.C. 12235 El Camino Real San Diego, California 92130 Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-acceleratedfiler, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2of the Exchange Act.

| Large accelerated filer |     | ☐ |     | Accelerated filer         |     | ☐ |
| Non-accelerated filer   |     | ☒ |     | Smaller reporting company |     | ☒ |
|                         |     |   |     | Emerging growth company   |     | ☐ |

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

EXPLANATORY NOTE This Registration Statement on Form S-8(the “ Registration Statement”) is filed by Whitehawk Therapeutics, Inc. (the “