Company: XXII
Filing Date: 2025-02-05
Form Type: S-3/A
Source: 0001493152-25-005039
Chunk: 0

Company: 22nd Century Group, Inc.
Filing Date: 2025-02-05
Form: S-3/A
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on February 5, 2025</div>

Registration No. 333-284644

<div align='center'>UNITED STATES
SECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549

Amendment No. 1 to

FORM S-3

REGISTRATION STATEMENT UNDER

THE SECURITIES ACT OF 1933

22nd CENTURY GROUP, INC.

(Exact name of registrant as specified in its charter)</div>

| Nevada                            
 (State                            
 or other jurisdiction             
 of incorporation or organization) |     | 98-0468420          
 (I.R.S.             
 Employer            
 Identification No.) |

<div align='center'>321 Farmington Rd

Mocksville, NC 27028

(336) 940-3769
(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

Daniel A. Otto

Chief Financial Officer

22nd Century Group, Inc.

321 Farmington Rd

Mocksville, NC 27028

(336) 940-3769

(Name, address, including zip code, and telephone number, including area code, of agent for service)

with a copy to:</div>

| John                          
 J. Wolfel, Esq.               
 Foley &                       
 Lardner LLP                   
 One                           
 Independent Drive, Suite 1300 
 Jacksonville,                 
 Florida 32202                 
 (904)                         
 359-2000                      | Jonathan            
 Staffeldt           
 General             
 Counsel             
 22nd                
 Century Group, Inc. 
 321                 
 Farmington Rd       
 Mocksville,         
 NC 27028            
 (336)               
 940-3769            |

Approximate date of commencement of proposed sale to the public:From time to time after this registration statement becomes effective.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, please check the following box. ☒

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement