Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 106

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 106
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 (or a combination of units thereof) involving a variable rate transaction (as defined in the securities
purchase agreement), subject to customary exceptions. The Placement Agent and purchaser may waive the terms of this lock-up period in their discretion.

Additionally, our officers and directors may not offer, pledge, announce the intention to sell, sell, contract to sell, sell any option or
contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, make any short sale or otherwise transfer or dispose of, directly or indirectly, enter any swap or other arrangement that transfers, and
make any demand for or exercise any right with respect to the registration of any of our ordinary shares, ADSs or any securities convertible into, or exercisable or exchangeable for, our ordinary shares or ADSs, subject to customary exceptions. The
Placement Agent may waive the terms of these lock-up agreements in its discretion.

Tail

We have also agreed to pay the Placement Agent a tail fee equal to the 8% cash fee on total gross proceeds in an offering, if any investor, who
was introduced by the Placement Agent to us during the term of its engagement, provides us with capital in any public or private offering or other financing or capital raising transaction during the twelve (12) month period following expiration
or termination of our engagement of the Placement Agent.

Regulation M

The Placement Agent may be deemed to be an underwriter within the meaning of Section 2(a)(11) of the Securities Act, and any commissions
received by it and any profit realized on the resale of the securities sold by it while acting as principal might be deemed to be underwriting discounts or commissions under the Securities Act. As an underwriter, the Placement Agent would be
required to comply with the requirements of the Securities Act and the Exchange Act, including, without limitation, Rule 10b-5 and Regulation M under the Exchange Act. These rules and regulations may limit the
timing of purchases and sales of our securities by the Placement Agent acting as principal. Under these rules and regulations, the Placement Agent (i) may not engage in any stabilization activity in connection with our securities and
(ii) may not bid for or purchase any of our securities or attempt to induce any person to purchase any of our securities, other than as permitted under the Exchange Act, until it has completed its participation in the distribution.

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Indemnification

We have agreed to indemnify the Placement Agent against certain liabilities, including certain liabilities arising under the