Company: DMAC
Filing Date: 2025-08-12
Form Type: S-3
Source: 0001437749-25-026273
Chunk: 0

Company: DiaMedica Therapeutics Inc.
Filing Date: 2025-08-12
Form: S-3
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on August 12, 2025.</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-3

REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

DIAMEDICA THERAPEUTICS INC.

(Exact name of registrant as specified in its charter)</div>

| British Columbia, Canada        
 (State or other jurisdiction of 
 incorporation or organization)  |     | Not Applicable         
 (I.R.S. Employer       
 Identification Number) |

<div align='center'>301 Carlson Parkway, Suite 210

Minneapolis, Minnesota 55305

(763) 496-5454

(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

Rick Pauls

President and Chief Executive Officer

DiaMedica Therapeutics Inc.

301 Carlson Parkway, Suite 210

Minneapolis, Minnesota 55305

(763) 496-5454

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copies to:</div>

| Matthew W. Mamak           
 Alston & Bird LLP          
 90 Park Avenue, 14th Floor 
 New York, New York 10016   
 (212) 210-1256             | Keith Inman               
 Pushor Mitchell LLP       
 301 - 1665 Ellis Street   
 Kelowna, British Columbia 
 Canada V1Y 2B3            
 (250) 762-2108            |

Approximate date of commencement of proposed sale to the public:From time to time after the effective date of this registration statement.

If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box: ☐

If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box: ☒

If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this Form is a