Company: SPRB
Filing Date: 2025-10-29
Form Type: S-3
Source: 0001193125-25-256662
Chunk: 41

Company: SPRUCE BIOSCIENCES, INC.
Filing Date: 2025-10-29
Form: S-3
Chunk 41
---
eded for purposes of the document to the extent that a statement contained in this document or any other subsequently filed document that is deemed to be incorporated by reference into this document modifies or supersedes the statement.

<div align='center'>32

$300,000,000

Common Stock

Preferred Stock

Debt Securities

Warrants</div>

PART II INFORMATION NOT REQUIRED IN PROSPECTUS Item 14. Other Expenses of Issuance and Distribution The following table sets forth the estimated costs and expenses, other than underwriting discounts and commissions, payable by us in connection with the offering of the securities being registered. All the amounts shown are estimates, except for the SEC registration fee.

| SEC registration fee                |     | $ | 41,430 |     | -1 |
| FINRA filing fee                    |     |   |        |     | -2 |
| Accounting fees and expenses        |     |   |        |     | -2 |
| Legal fees and expenses             |     |   |        |     | -2 |
| Transfer agent fees and expenses    |     |   |        |     | -2 |
| Trustee fees and expenses           |     |   |        |     | -2 |
| Printing and miscellaneous expenses |     |   |        |     | -2 |
| Total(3)                            |     | $ | 41,430 |     |    |

(1) These fees comprise the registration fee for the registration of an aggregate amount of $300,000,000 of any combination of the securities described in this prospectus to be offered by the registrant. Please see the registration fee table contained in Exhibit 107 to this registration statement for more information. (2) These fees are calculated based on the securities offered and the number of issuances and accordingly cannot be estimated at this time. (3) Does not include any fees or expenses in connection with any subsequent underwritten offering and any supplements prepared in connection therewith. Item 15. Indemnification of Directors and Officers Section 145 of the Delaware General Corporation Law authorizes a court to award, or a corporation’s board of directors to grant, indemnity to directors and officers in terms sufficiently broad to permit such indemnification under certain circumstances for liabilities, including reimbursement for expenses incurred, arising under the Securities Act. Our amended and restated certificate of incorporation permits indemnification of our directors, officers, employees and other agents to the maximum extent permitted by the Delaware General Corporation Law, and our amended and rest