Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 23

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 23
---
 transfer agent or registrar.

#### Clearance and Settlement
The Notes have been accepted for clearance through DTC, Euroclear and Clearstream.

<div align='center'>S-17</div>

### TAXATION

#### Japanese Taxation
The following general description of certain aspects of Japanese taxation (limited to those regarding national taxes) is applicable to the Notes to be offered or sold outside Japan. It is not intended to constitute a complete analysis of all the tax consequences relating to the purchase, ownership and disposition of the Notes. Prospective purchasers should consult their own tax advisers as to the exact tax consequences of their particular situations.

The payment of principal and interest in respect of the Notes to an individual non-resident of Japan or a non-Japanese corporation will not, in general, be subject to any Japanese income tax or corporation tax, unless the receipt of the relevant payment is the income of such individual non-resident or non-Japanese corporation from sources in Japan and/or TPC is deemed to be an issuer of the Notes.

The tax treatment of interest and the redemption gain arising from the payment by TPC under the Guarantee to an individual non-resident of Japan or a non-Japanese corporation having no permanent establishment within Japan is unclear under Japanese law , especially when net proceeds from the offering of the Notes are used for TPC’s business in Japan (see “Use of Proceeds”). If the interest is considered to be from a source in Japan, the payment may be subject to Japanese withholding tax and to the Income Tax Act of Japan (Act No. 33 of 1965, as amended) and other applicable tax laws. Furthermore, if the redemption gain is considered to be from a source in Japan, income tax or corporate tax, as appropriate, other than by way of withholding, may be payable with respect to the redemption gain. For the additional amounts to be paid in the event that the payment under the Guarantee is subject to Japanese withholding tax, see “Description of Guaranteed Senior Debt Securities—Taxation and Additional Amounts.”

Gains derived from the sale of Notes outside Japan by an individual non-resident of Japan or a non-Japanese corporation having no permanent establishment within Japan are, in general, not subject to Japanese income tax or corporate tax.

No stamp, issue, registration or similar taxes or duties will, under current Japanese law, be payable in Japan by holders of the Notes in connection with the issue of the Notes.

Japanese inheritance tax or gift tax at progressive rates may be payable by an individual, wherever resident, who has acquired Notes