Company: SCLXW
Filing Date: 2025-08-21
Form Type: 424B3
Source: 0001193125-25-184626
Chunk: 13

Company: Scilex Holding Co
Filing Date: 2025-08-21
Form: 424B3
Chunk 13
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 Agreement, that certain Intellectual Property Security Agreement, dated as of
July 28, 2023, by the Debtors in the Company’s favor, any other Loan Document (as defined in the Junior DIP Loan Agreement) and any other notes, security agreements, mortgages, pledge agreements, guarantees or other agreements, documents,
certificates or instruments related thereto automatically terminated, and all obligations thereunder were paid and discharged in full.

In connection with the Legal Fee Assumption in accordance with the Sorrento SPA, the Company and Sorrento entered into a
letter agreement on September 21, 2023, pursuant to which, among other things, the Company agreed to assume all of Sorrento’s obligations for certain legal fees and expenses in the aggregate amount of approximately $12.25 million.

On August 21, 2025, the Company issued a press release announcing, among other things, the management changes described in Item 5.02 of this Current
Report on Form 8-K. A copy of this press release is furnished with this report as Exhibit 99.1 and incorporated herein by reference.

Item 9.01. Financial Statements and Exhibits.

(d)
Exhibits.

6

| Exhibit 
 Number  
 99.1    |     | Description                                                                                           
 Press Release, dated August 21, 2025.                                                                 |
|:--------|:----|:------------------------------------------------------------------------------------------------------|
| 104     |     | Cover Page Interactive Data File, formatted in Inline Extensible Business Reporting Language (iXBRL). |

7

SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

| SCILEX HOLDING COMPANY |     |                                     |
| By:                    |     | /s/ Henry Ji                        |
| Name:                  |     | Henry Ji                            |
| Title:                 |     | Chief Executive Officer & President |

Date: August 21, 2025 8

Exhibit 99.1

Scilex Holding Company (Nasdaq: SCLX) Announces Its Majority-Owned Subsidiary, Semnur Pharmaceuticals, Inc. (“Semnur”), and Denali Capital Acquisition Corp. Have Entered into a Purchase Agreement with an Investor for a $20 Million Private Placement at $16.00 per share and Jaisim Shah, Scilex’s CEO and President, Will be Dedicated