Company: PSTV
Filing Date: 2025-06-18
Form Type: S-1
Source: 0001193125-25-142215
Chunk: 48

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-06-18
Form: S-1
Chunk 48
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 5.1 hereto).                                                  |     |                           |     |             |     |         |     |             |
| 24.1    |     | Power of Attorney.                                                                                                     |     |                           |     |             |     |         |     |             |
| 107     |     | Filing Fee Table                                                                                                       |     |                           |     |             |     |         |     |             |

| 

# | Indicates management contract or compensatory plan or arrangement. |
| + | Portions of this exhibit have been redacted pursuant to Item 601(b)(10)(iv). |

| * | To be filed by amendment. |

II-9

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Houston, State of Texas, on June 17, 2025.

| PLUS THERAPEUTICS, INC. |     |                                       |
| By:                     |     | /s/ Marc H. Hedrick                   |
|                         |     | Marc H. Hedrick, MD                   |
|                         |     | President and Chief Executive Officer |

POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Marc H. Hedrick, MD and Andrew Sims, and each of them, his or her true and lawful attorneys-in-factand agents, with full power of substitution and re-substitution,for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Registration Statement, and any registration statement relating to the offering covered by this Registration Statement and filed pursuant to Rule 462(b) under the Securities Act of 1933, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-factand agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully for all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys in fact and agents or their substitute or substitutes may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the