Company: SCLXW
Filing Date: 2025-09-29
Form Type: 424B3
Source: 0001193125-25-221018
Chunk: 19

Company: Scilex Holding Co
Filing Date: 2025-09-29
Form: 424B3
Chunk 19
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, 2025, the Company issued a press release announcing the execution of the Biconomy Resale SPA. A copy of the press release is attached as Exhibit 99.1 to this Current Report on Form 8-Kand is incorporated herein by reference. The information in Item 7.01 of this Current Report on Form 8-K (including Exhibit99.1 attached hereto) is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall they be deemed incorporated by reference into any filing by the Company, under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such filing. Item 8.01. Other Events. In connection with the Biconomy Resale SPA and related transactions described herein, the Company is filing certain updated risk factors disclosure applicable to its business for the purpose of supplementing and updating disclosures contained in the Company’s prior public filings, including those discussed under the heading “Item 1A. Risk Factors” in the Company’s Annual Report on Form 10-Kfor the year ended December 31, 2024, filed with the SEC on March 31, 2025 (as amended). The supplemental updated risk factors are filed herewith as Exhibit 99.2 and are incorporated herein by reference. Item 9.01. Financial Statements and Exhibits. (d) Exhibits.

| Exhibit 
 Number  
 10.1#   
 99.1    |     | Description                                                                                                                                              
 Securities Purchase Agreement, dated September 23, 2025, by and among Scilex Holding Company, Scilex, Inc., Semnur Pharmaceuticals and Biconomy PTE.LTD. 
 Press release dated September 23, 2025.                                                                                                                  |
|:--------|:----|:---------------------------------------------------------------------------------------------------------------------------------------------------------|
| 99.2    |     | Supplemental Risk Factors.                                                                                                                               |
| 104     |     | Cover Page Interactive Data File, formatted in Inline Extensible Business Reporting Language (iXBRL).                                                    |

| 

# | Certain of the exhibits and schedules to this Exhibit have been omitted in accordance with Regulation S-K Item 601. The Company agrees to furnish a copy of all omitted exhibits and schedules to the SEC upon its request. |
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SIGNATURES Pursuant to the requirements