Company: GANX
Filing Date: 2025-04-17
Form Type: PRE 14A
Source: 0001558370-25-004958
Chunk: 1

Company: Gain Therapeutics, Inc.
Filing Date: 2025-04-17
Form: PRE 14A
Chunk 1
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ated Certificate of Incorporation to increase its authorized shares of common stock from 50,000,000 to 100,000,000. |

| 4. | To approve the adjournment of the Annual Meeting to a later date or dates, if necessary or appropriate, to permit further solicitation and vote of proxies in the event that there are insufficient votes for, or otherwise in connection with, the approval of Proposal 3. |

| 5. | To conduct any other business properly brought before the Annual Meeting. |

These items of business are more fully described in the Proxy Statement accompanying this notice. The record date for the Annual Meeting is April 25, 2025. Only stockholders of record at the close of business on that date may vote at the Annual Meeting or any adjournment or postponement thereof. A list of stockholders of record will be available for inspection by stockholders of record during normal business hours for ten days prior to the Annual Meeting for any legally valid purpose at our corporate headquarters located at 4800 Montgomery Lane, Suite 220, Bethesda, Maryland 20814. The stockholder list will also be available during the Annual Meeting. By Order of the Board of Directors,

| ​                       | ​ |
| ​                       | ​ |
| Gene Mack               | ​ |
| Chief Executive Officer | ​ |
| Bethesda, Maryland      | ​ |
| April [●], 2025         | ​ |

| ​                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
| You are cordially invited to attend the Annual Meeting in person. Whether or not you expect to attend the Annual Meeting, please vote over the telephone or the internet as instructed in these materials or, if you receive a paper proxy card, by completing and returning the proxy mailed to you, as promptly as possible in order to ensure your representation at the Annual Meeting. Even if you have voted by proxy, you may still vote in person if you attend the Annual Meeting. Please note, however, that if your shares are held of record by a broker, bank or other nominee and you wish to vote at the Annual Meeting, you must obtain a proxy issued in your name from that record holder. |

#### GAIN THERAPEUTICS, INC.
<div align='center'>4800 Montgomery Lane, Suite 220

Bethesda, Maryland 20814</div>

### PROXY STATEMENT

#### FOR THE 2025 ANNUAL MEETING OF STOCKHOLDERS
<div align='center'>To Be Held on June 24,