Company: PSTV
Filing Date: 2025-06-17
Form Type: CORRESP
Source: 0001193125-25-142216
Chunk: 0

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-06-17
Form: CORRESP
Chunk 0
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June 17, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549

| Re: | Plus Therapeutics, Inc. |

| File No. 333- |

| Request for Acceleration of Effective Date |

Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended (the “ Securities Act”), Plus Therapeutics, Inc. hereby requests for acceleration of the effective date of the above-referenced registration statement on Form S-1,as amended (the “ Registration Statement”), so that it becomes effective as of 9:00 a.m. Eastern Time on Monday, June 23, 2025, or as soon thereafter as possible. [Signature Page to Follow]

| Very truly yours,       |     |                         |
| Plus Therapeutics, Inc. |     |                         |
| By:                     |     | /s/ Andrew Sims         |
| Name:                   |     | Andrew Sims             |
| Title:                  |     | Chief Financial Officer |

cc: Aaron M. Schleicher, Sullivan & Worcester LLP [Signature Page to Acceleration Request]