Company: NCNA
Filing Date: 2025-04-24
Form Type: F-1
Source: 0001193125-25-092131
Chunk: 114

Company: NuCana plc
Filing Date: 2025-04-24
Form: F-1
Chunk 114
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 under the Securities Act of 1933, and all post-effective amendments thereto, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-factand agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-factand agents, or their or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

| Signature             
 /s/ Hugh S. Griffith  
 Hugh S. Griffith      
 /s/ Ian Webster       
 Ian Webster           |     | Title                                        
 Chief Executive Officer and Director         
 (Principal Executive Officer)                
 Director of Finance                          
 (Principal Financial and Accounting Officer) |     | Date           
 April 23, 2025 
 April 23, 2025 |
|:----------------------|:----|:---------------------------------------------|:----|:---------------|
| /s/ Andrew Kay        
 Andrew Kay            |     | Chairman                                     |     | April 23, 2025 |
| /s/ Bali Muralidhar   
 Bali Muralidhar       |     | Director                                     |     | April 23, 2025 |
| /s/ Cyrille Leperlier 
 Cyrille Leperlier     |     | Director                                     |     | April 23, 2025 |
| /s/ Elliot Levy       
 Elliot Levy           |     | Director                                     |     | April 23, 2025 |
| /s/ Martin Mellish    
 Martin Mellish        |     | Director                                     |     | April 23, 2025 |

II-6

SIGNATURE OF AUTHORIZED U.S. REPRESENTATIVE OF THE REGISTRANT Pursuant to the Securities Act of 1933, the undersigned, the duly authorized representative in the United States of NuCana plc has signed this registration statement or amendment thereto on April 23, 2025.

| NUCANA, INC. |     |                              |
| By:          |     | /s/ Jeffrey Bloss, M.D.      |
|              |     | Name: Jeffrey Bloss, M.D