Company: RGNX
Filing Date: 2025-03-13
Form Type: POS AM
Source: 0001193125-25-053998
Chunk: 3

Company: REGENXBIO Inc.
Filing Date: 2025-03-13
Form: POS AM
Chunk 3
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 you should carefully read and consider the risks we describe in this prospectus and in any accompanying prospectus supplement, as well as the risk factors that are incorporated by reference into this prospectus and in any accompanying prospectus supplement from our filings made with the Securities and Exchange Commission. See “ Risk Factors” beginning on page 3 of this prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

The date of this prospectus is , 2025

TABLE OF CONTENTS

| SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS |     | ii |
| ABOUT THIS PROSPECTUS                             |     |  1 |
| WHERE YOU CAN FIND MORE INFORMATION               |     |  1 |
| THE COMPANY                                       |     |  3 |
| RISK FACTORS                                      |     |  3 |
| USE OF PROCEEDS                                   |     |  3 |
| DESCRIPTION OF CAPITAL STOCK                      |     |  4 |
| DESCRIPTION OF WARRANTS                           |     | 10 |
| DESCRIPTION OF DEBT SECURITIES                    |     | 13 |
| DESCRIPTION OF RIGHTS                             |     | 21 |
| DESCRIPTION OF UNITS                              |     | 23 |
| PLAN OF DISTRIBUTION                              |     | 24 |
| LEGAL MATTERS                                     |     | 27 |
| EXPERTS                                           |     | 27 |

i

SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS This prospectus, each prospectus supplement and the information incorporated by reference in this prospectus and each prospectus supplement contain “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), which are subject to the safe harbor created by those sections for such statements. These statements express a belief, expectation or intention and are generally accompanied by words that convey projected future events or outcomes such as “anticipate,” “assume,” “believe,” “continue,” “could,” “design,” “estimate,” “expect,” “forecast,” “goal,” “intend,” “may,” “objective,” “plan,” “position,” “potential,” “predict,” “project,” “seek,” “should,” “will,” “would” or