Company: SCLXW
Filing Date: 2025-05-14
Form Type: 424B3
Source: 0001193125-25-119831
Chunk: 30

Company: Scilex Holding Co
Filing Date: 2025-05-14
Form: 424B3
Chunk 30
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Risks Related to our Relationship with Sorrento

| • |     | Sorrento previously supported many of our important corporate functions. Accordingly, our historical consolidated                                                                                                                                         
 financial statements may not necessarily be indicative of the conditions that would have existed or our results of operations if we had been operated as an unaffiliated company of Sorrento, and we have and will continue to incur incremental costs as 
 a stand-alone public company.                                                                                                                                                                                                                             |

Risks Related to Ownership of our Common Stock

| • |     | If our operations and performance do not meet the expectations of investors or securities analysts, the market 
 price of our securities may decline.                                                                           |

| • |     | We are an emerging growth company, and we cannot be certain if the reduced reporting requirements applicable to 
 emerging growth companies will make our Common Stock less attractive to investors.                              |

| • |     | The Selling Stockholder acquired or may acquire the securities covered by this prospectus at a price that is              
 substantially below the current trading price of such securities and may therefore make substantial profits upon resales. |

Corporate Information We were incorporated under the name “Vickers Vantage Corp. I” on February 21, 2020 as a Cayman Islands exempted company for the purpose of effecting a merger, share exchange, asset acquisition, share purchase, reorganization or similar business combination with one or more businesses or entities. On November 9, 2022, we changed our jurisdiction of incorporation by deregistering as a Cayman Islands exempted company and continuing and domesticating as a corporation incorporated under the laws of the State of Delaware. On November 9, 2022, we changed our name to “Scilex Holding Company”. Our principal executive offices are located at 960 San Antonio Road, Palo Alto, California 94303, and our telephone number is (650) 516-4310.Our website address is www.scilexholding.com. Any information contained on, or that can be accessed through, our website is not incorporated by reference into, nor is it in any way part of this prospectus and should not be relied upon in connection with making any decision with respect to an investment in our securities. We are required to file annual, quarterly and current reports, proxy statements and other information with the SEC. You may obtain any of the documents filed by us with the SEC at no cost from the SEC’s website at http://www.sec.gov.

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THE OFFERING Resale of Common Stock

| Shares