Company: SION
Filing Date: 2025-02-03
Form Type: S-1/A
Source: 0001193125-25-018825
Chunk: 121

Company: Sionna Therapeutics, Inc.
Filing Date: 2025-02-03
Form: S-1/A
Chunk 121
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 competitors and our industry, including competing product candidates and therapies; |

| • |     | existing regulations and regulatory developments in the U.S. and other jurisdictions; |

| • |     | expectations regarding future events under collaboration and licensing agreements, including potential future payments, as 
 well as our plans and strategies for entering into further collaboration and licensing agreements;                         |

| • |     | general economic, industry and market conditions, including rising interest rates and inflation; |

| • |     | our ability to attract and retain the continued service of our key personnel and to identify, hire and then retain 
 additional qualified personnel;                                                                                    |

| • |     | our expectations regarding the period during which we will qualify as an emerging growth company under the JOBS Act; and |

84

| • |     | our anticipated use of our existing cash, cash equivalents and investments in marketable securities and the proceeds from 
 this offering.                                                                                                            |

We have based these forward-looking statements largely on our current expectations and projections about our business, the industry in which we operate and financial trends that we believe may affect our business, financial condition, results of operations and prospects, and these forward-looking statements are not guarantees of future performance or development. These forward-looking statements speak only as of the date of this prospectus and are subject to a number of risks, uncertainties and assumptions described in “ Risk Factors” and elsewhere in this prospectus. Because forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified, you should not rely on these forward-looking statements as predictions of future events. The events and circumstances reflected in our forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in the forward-looking statements. Except as required by applicable law, we do not plan to publicly update or revise any forward-looking statements contained herein until after we distribute this prospectus, whether as a result of any new information, future events or otherwise. In addition, statements that “we believe” and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based upon information available to us as of the date of this prospectus, and while we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete, and our statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all potentially available relevant information. These statements are inherently uncertain, and you are cautioned not to unduly rely upon these statements. You should read this prospectus