Company: NCNA
Filing Date: 2025-06-20
Form Type: 6-K
Source: 0001193125-25-143671
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Company: NuCana plc
Filing Date: 2025-06-20
Form: 6-K
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### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN PRIVATE ISSUER

PURSUANT TO RULE 13a-16 OR 15d-16

OF THE SECURITIES EXCHANGE ACT OF 1934

For the month of June 2025

(Commission File No. 001-38215)

### NUCANA PLC
(Translation of registrant’s name into English)

3 Lochside Way

Edinburgh EH12 9DT

United Kingdom

(Address of registrant’s principal executive office)

Indicate by check mark whether the registrant files or will file annual reports under cover Form 20-F or Form 40-F.

Form
20-F ☒ Form 40-F ☐

Indicate by check mark if the registrant is
submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101 (b) (1): ☐

Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101 (b) (7): ☐

Other Events

On June 18, 2025, NuCana plc (the “Company”) received a written notification (the “Notice”) from the Listing Qualifications Department
of The Nasdaq Stock Market, LLC (“Nasdaq”) notifying the Company that, for the preceding 30 consecutive trading days, the closing bid price of its American Depositary Shares (“ADSs”) was below the $1.00 per share minimum bid
price requirement for continued inclusion on The Nasdaq Capital Market pursuant to Nasdaq Listing Rule 5550(a)(2) (the “Bid Price Requirement”). This Notice has no immediate effect on the listing of the Company’s ADSs, which continue
to trade on The Nasdaq Capital Market under the symbol “NCNA”.

In accordance with Nasdaq Listing Rule 5810(c)(3)(A), the Company has until
December 15, 2025 (the “Compliance Date”) to regain compliance with the Bid Price Requirement. According to the Notice, if the closing bid price of the Company’s ADSs is least $1.00 per share for a minimum of 10 consecutive
business days before the Compliance Date, Nasdaq will provide written notification that the Company has achieved compliance with the Bid Price Requirement and its ADSs will continue to be eligible for listing on The Nasdaq Capital