Company: MTB-PJ
Filing Date: 2025-07-29
Form Type: 424B2
Source: 0001193125-25-167978
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Company: M&T BANK CORP
Filing Date: 2025-07-29
Form: 424B2
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 factors contained in our annual, quarterly and current reports filed with the Securities and Exchange Commission (the “SEC”) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), which are incorporated herein by reference. None of the Securities and Exchange Commission (the “SEC”), any state securities commission, the New York State Department of Financial Services or the Board of Governors of the Federal Reserve System or any other governmental agency has approved or disapproved of the notes passed upon the adequacy or accuracy of this pricing supplement or the accompanying prospectus. Any representation to the contrary is a criminal offense.

|                                      |     | Per Note |        |   |     | Total |             |
|:-------------------------------------|:----|:---------|-------:|:--|:----|:------|------------:|
| Price to Public                      |     |          | 100.00 | % |     | $     | 750,000,000 |
| Agents’ Discount                     |     |          |   0.13 | % |     | $     |     975,000 |
| Net Proceeds (Before Expenses) to Us |     |          |  99.87 | % |     | $     | 749,025,000 |

We expect to deliver the Notes to investors through the book-entry delivery system of The Depository Trust Company and its direct participants, including Euroclear Bank, SA/NV and Clearstream Banking, société anonyme, on or about July 30, 2025. Joint Book-Running Managers

| Barclays |     | J.P. Morgan |     | RBC Capital Markets |     | M&T Securities |

Co-Managers

| AmeriVet Securities |     | Blaylock Van, LLC |

July 28, 2025

RECENT DEVELOPMENTS

M&T Preliminary Second Quarter Results

On July 16, 2025, M&T reported its unaudited preliminary financial results for the quarter ended June 30, 2025. The preliminary
financial data included in this pricing supplement has been prepared by, and is the responsibility of, M&T’s management. PricewaterhouseCoopers LLP has not audited, reviewed, examined, compiled, nor applied agreed-upon procedures with
respect to the preliminary financial data. Accordingly, PricewaterhouseCoopers LLP does not express an opinion or any other form of assurance with respect thereto.

Diluted earnings per common share measured in accordance with generally accepted accounting