Company: PFSA
Filing Date: 2025-10-29
Form Type: 424B3
Source: 0001213900-25-103174
Chunk: 1

Company: Profusa, Inc.
Filing Date: 2025-10-29
Form: 424B3
Chunk 1
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 Securities through ordinary brokerage transactions, in underwritten offerings, directly to market makers of our securities
or through any other means described in the section entitled “Plan of Distribution” herein. In connection with any
sales of Resale Securities offered hereunder, the Selling Stockholders, any underwriters, agents, brokers or dealers participating in
such sales may be deemed to be “underwriters” within the meaning of the Securities Act, or the Exchange Act. We are registering
the Resale Securities for resale by the Selling Stockholders, or their donees, pledgees, transferees, distributees or other successors-in-interest
selling our Common Stock received after the date of this prospectus from the Selling Stockholders as a gift, pledge, partnership distribution
or other transfer.

The Selling Stockholders may
sell the shares of our common stock offered by this prospectus from time to time on terms to be determined at the time of sale through
ordinary brokerage transactions or through any other means described in this prospectus under the caption “Plan of Distribution.”
The shares of common stock may be sold at fixed prices, at market prices prevailing at the time of sale, at prices related to prevailing
market price or at negotiated prices.

We will pay the expenses incurred
in registering under the Securities Act the offer and sale of the shares of Common Stock to which this prospectus relates by the Selling
Stockholders, including legal and accounting fees. See “Plan of Distribution — Offer and Resale of Common Stock by the Selling Stockholders” beginning on page 145.

Our common stock is listed
on the Nasdaq Global Market under the symbol “PFSA.” On October 7, 2025, the last sale price for our common stock as reported
on the Nasdaq Global Market was $0.33 per share.

We are a “smaller reporting
company” as defined under the federal securities laws and, as such, have elected to comply with certain reduced public company reporting
requirements for this prospectus and may elect to do so in future filings.

Investing in our securities involves a high degree of risk. See the section entitled“ Risk Factors” appearing on page 5 of this prospectus for a discussion of information that should be considered in connection with an investment in our securities.

Neither the Securities and Exchange Commission nor any other regulatory body has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.

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