Company: TVRD
Filing Date: 2025-02-14
Form Type: S-4/A
Source: 0001104659-25-013053
Chunk: 1182

Company: Tvardi Therapeutics, Inc.
Filing Date: 2025-02-14
Form: S-4/A
Chunk 1182
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<div align='center'>E-12</div>

TABLE OF CONTENTS

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TABLE OF CONTENTS

### ANNEX F

### FORM OF

### CERTIFICATE OF AMENDMENT

#### TO

### AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

#### OF

#### CARA THERAPEUTICS, INC.
Cara Therapeutics, Inc. (the “

#### Company
”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “

#### DGCL
**”), does hereby certify that:

FIRST: The name of this corporation is Cara Therapeutics, Inc., and the date on which the Certificate of Incorporation of this corporation was originally filed with the Secretary of State of the State of Delaware was July 2, 2004, under the original name Cara Therapeutics, Inc.

SECOND:**

#### The Board of Directors of the Company (the “

#### Board
**”), acting in accordance with the provisions of Sections 141 and 242 of the DGCL, adopted resolutions amending its Certificate of Incorporation (the “**

#### Certificate of Incorporation
”), as follows:

Effective as of the effective time of [5:00 p.m.], Eastern Time, on [***DATE***] (1) (the “

#### Effective Time
”), each [•] shares of the Company’s Common Stock, par value $0.001 per share, issued and outstanding immediately prior to the Effective Time shall, automatically and without any action on the part of the Company or the respective holders thereof, be combined into one (1) share of Common Stock without increasing or decreasing the par value of each share of Common Stock (the “

#### Reverse Split
**”); provided, however, no fractional shares of Common Stock shall be issued as a result of the Reverse Split and, in lieu thereof, upon receipt after the Effective Time by the exchange agent selected by the Company of a properly completed and duly executed transmittal letter and, where shares are held in certificated form, the surrender of the stock certificate(s) formerly representing shares of pre-Reverse Split Common Stock, any stockholder who would otherwise be entitled to a fractional share of post-Reverse Split Common Stock as a result of the Reverse Split,