Company: SNY
Filing Date: 2025-10-29
Form Type: 424B5
Source: 0001193125-25-255563
Chunk: 4

Company: Sanofi
Filing Date: 2025-10-29
Form: 424B5
Chunk 4
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. Business overview” of our 2024 Annual Report on Form 20-F,as defined herein, and other documents incorporated by reference in this prospectus supplement. Examples of such forward-looking statements include:

| • |     | projections of operating revenues, net income, business net income, earnings per share, business earnings per                                                    
 share, capital expenditures, cost savings, restructuring costs, positive or negative synergies, dividends, capital structure or other financial items or ratios; |

| • |     | statements of our profit forecasts, trends, business strategies, plans, objectives or goals, including those 
 relating to products, clinical studies, regulatory approvals and competition; and                            |

| • |     | statements about our future events and economic performance or that of France, the United States or any other 
 countries in which we operate.                                                                                |

This information is based on data, assumptions and estimates considered as reasonable by Sanofi as at the date of this prospectus supplement and undue reliance should not be placed on such statements. Words such as “believe,” “anticipate,” “can,” “contemplate,” “could,” “plan,” “expect,” “intend,” “is designed to,” “may,” “might,” “potential,” “objective,” “target,” “estimate,” “project,” “predict,” “forecast,” “ambition,” “guideline,” “seek,” “should,” “will,” “goal,” or the negative of these and similar expressions are intended to identify forward-looking statements but are not the exclusive means of identifying such statements. Forward-looking statements involve inherent, known and unknown risks, uncertainties and assumptions associated with the regulatory, economic, political, financial and competitive environment, and other factors, including changes in tariffs, pricing and other matters, that could cause actual future results to differ materially from those expressed or implied in the forward-looking statements. These risks, uncertainties and assumptions include risk factors that could also affect future results and cause actual results to differ materially from those contained in any forward-looking statements, and that include those discussed under “Item 3. Key Information—D. Risk Factors” of our 2024 Form 20-F(as defined herein). Additional risks, not currently known or that are currently considered immaterial by the Group, may have the same unfavorable effect and investors may lose all or part of their investment. As a result of these factors, we cannot assure you that the forward-looking statements in this prospectus supplement and the attached prospectus will prove to be accurate. Furthermore, if our forward-looking