Company: NCNA
Filing Date: 2025-04-29
Form Type: F-1/A
Source: 0001193125-25-103135
Chunk: 112

Company: NuCana plc
Filing Date: 2025-04-29
Form: F-1/A
Chunk 112
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 acts or omissions while in the course of acting or purporting to act as our director or officer or which otherwise arises by virtue of such director or officer holding or having held such a position. We have also purchased and maintain directors’ and officers’ liability insurance to insure, for the period of their appointment, each of its directors and officers in respect of their appointments as our directors or officers. Under the Companies Act 2006, any provision (whether contained in a company’s articles of association or any contract or otherwise) that purports to exempt a director of a company, to any extent, from any liability that would otherwise attach to him in connection with any negligence, default, breach of duty or breach of trust in relation to the company is void. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers or persons controlling us pursuant to the foregoing provisions, we have been informed that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable. II-1

| Item 7. | Recent sales of unregistered securities |

None.

| Item 8. | Exhibits and Financial Statement Schedules |

(a) Exhibits

| Exhibit 
 Number  |     | Description of Exhibits                                                                                                                                                                                |
| 1.1^    |     | Form of Placement Agency Agreement.                                                                                                                                                                    |
| 3.1*    |     | Articles of Association of the registrant.                                                                                                                                                             |
| 4.1     |     | Form of certificate evidencing ordinary shares (incorporated by reference to Exhibit 4.1 of the Company’s Registration Statement on Form                                                               
 F-1/A, filed with the SEC on September 18, 2017).                                                                                                                                                      |
| 4.2     |     | Deposit Agreement, by and among the registrant and Citibank, N.A. and all Holders and Beneficial Owners of ADSs issued hereunder, dated as of                                                          
 October 2, 2017 (incorporated by reference to Exhibit 2.1 of the Company’s Annual Report on Form 20-F filed with the SEC on March 22, 2018).                                                           |
| 4.3*    |     | Amendment No. 1 to Deposit Agreement, by and among the registrant and Citibank, N.A. and all Holders and Beneficial Owners of ADSs issued hereunder,                                                   
 dated as of