Company: BDRX
Filing Date: 2025-05-08
Form Type: POS AM
Source: 0001214659-25-007201
Chunk: 75

Company: Biodexa Pharmaceuticals Plc
Filing Date: 2025-05-08
Form: POS AM
Chunk 75
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 or other taxes and other governmental charges, transfer or registration fees, a transaction fee per
cancellation request (including any cancellation request made through SWIFT, facsimile transmission or any other method of communication),
applicable delivery expenses or other such fees, charges or expenses), or otherwise prejudices any substantial existing right of ADR holders
or beneficial owners. Such notice need not describe in detail the specific amendments effectuated thereby, but must identify to ADR holders
and beneficial owners a means to access the text of such amendment. If an ADR holder or beneficial owner continues to hold an ADR or ADRs,
or an interest therein, after being so notified, such ADR holder and any beneficial owner are deemed to agree to such amendment and to
be bound by the Deposit Agreement as so amended. No amendment, however, will impair your right to surrender your Depositary Shares and
receive the underlying securities, except in order to comply with mandatory provisions of applicable law.

| 52 |

Any amendments
or supplements that (i) are reasonably necessary (as agreed by us and the depositary) in order for (a) the Depositary Shares to be registered
on Form F-6 under the Securities Act or (b) the Depositary Shares or Ordinary Shares to be traded solely in electronic book-entry form
and (ii) do not in either such case impose or increase any fees or charges to be borne by ADR holders, shall be deemed not to prejudice
any substantial rights of ADR holders or beneficial owners. Notwithstanding the foregoing, if any governmental body or regulatory body
should adopt new laws, rules or regulations that would require amendment or supplement of the Deposit Agreement or the form of ADR to
ensure compliance therewith, we and the depositary may amend or supplement the Deposit Agreement and the form of ADR (and all outstanding
ADRs) at any time in accordance with such changed laws, rules or regulations. Such amendment or supplement to the Deposit Agreement in
such circumstances may become effective before a notice of such amendment or supplement is given to ADR holders or within any other period
of time as required for compliance.

Notice of any amendment to the Deposit Agreement
or form of ADRs shall not need to describe in detail the specific amendments effectuated thereby, and failure to describe the specific
amendments in any such notice shall not render such notice invalid, provided, however, that, in each such case, the notice given to the
ADR holders identifies a means for ADR holders