Company: APM
Filing Date: 2025-07-15
Form Type: DRS
Source: 0001213900-25-063906
Chunk: 336

Company: Aptorum Group Ltd
Filing Date: 2025-07-15
Form: DRS
Chunk 336
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 microRNA biomarkers for detection of mild cognitive impairment. Kira S. Sheinerman, Vladimir G. Tsivinsky, Fiona Crawford, Michael J. Mullan, Laila Abdullah, and Samuil R. Umansky. Aging, 4: 590 -607(2012) DiamiR’s data was also presented at numerous scientific and industry conferences, most recently: Child Neurology Society, October 2023, Vancouver, Canada, Rett Syndrome Foundation Research Trust Conference, September 2023, Boston MA, Alzheimer’s Association International Conference 2023, Amsterdam, Netherlands, 15 THClinical Trials on Alzheimer’s Disease (CTAD), San Francisco, CA, Alzheimer’s Association International Conference 2022, San Diego, CA. Grants and Awards Since its inception, DiamiR has raised over $9.7 million grant funding from government agencies and disease foundations. On October 1, 2020, DiamiR announced that it received two grants from the National Institutes of Health (NIH) in the total amount of approximately $3.86 million. The National Institute on Aging (NIA) awarded DiamiR approximately $3.36 million in a Commercialization Readiness Pilot (CRP) grant as part of its Small Business Innovation Research (SBIR) program. The award builds upon earlier studies conducted by DiamiR in collaboration with leading academic centers and continues to support development of CogniMIR ®, DiamiR’s lead diagnostic product candidate for early detection and monitoring of mild cognitive impairment and AD. The second award of $498,572 was granted to DiamiR by the National Institute for Neurological Disorders and Stroke (NINDS) for a project entitled “Circulating Organ -enrichedmicroRNAs as biomarkers of Rett Syndrome.” 201 DiamiR has received non -dilutivefunding to support its work. Below is a summary of DiamiR’s awards to date: ____________ *indicates grants from the National Institutes of Health (NIH). NIH/NIA SBIR CRP Grant Number 2R44AG044860 -0709/01/2020 – 04/30/2024 Title: Brain -enrichedmicroRNAs detectable in plasma as biomarkers of Alzheimer’s disease Analytical validation of CogniMIR ®miRNA panel, and other studies supporting commercialization of the test within a CLIA/CAP laboratory. NIH/NINDS SBIR Phase I