Company: PCRX
Filing Date: 2025-08-05
Form Type: S-8
Source: 0001396814-25-000105
Chunk: 3

Company: Pacira BioSciences, Inc.
Filing Date: 2025-08-05
Form: S-8
Chunk 3
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| Exhibit No. |     | Description                                                                                                                                                                                |
| 5.1         |     | Opinion of Perkins Coie LLP.                                                                                                                                                               |
| 23.1        |     | Consent of KPMG LLP.                                                                                                                                                                       |
| 23.2        |     | Consent of Perkins Coie LLP (included in Exhibit 5.1).                                                                                                                                     |
| 24.1        |     | Power of Attorney (see signature page of this Registration Statement).                                                                                                                     |
| 99.1        |     | Pacira BioSciences, Inc. Amended and Restated 2011 Stock Incentive Plan (incorporated by reference to Exhibit 10.1 of the registrant’s Current Report on Form 8-K filed on June 13, 2025). |
| 107         |     | Filing Fee Table.                                                                                                                                                                          |

### SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Brisbane, State of California, on August 5, 2025.

| PACIRA BIOSCIENCES, INC.             |
| /s/ FRANK D. LEE                     |
| Frank D. Lee                         
 Chief Executive Officer and Director |

### POWER OF ATTORNEY
Each person whose individual signature appears below hereby authorizes Frank D. Lee, Shawn M. Cross and Kristen Williams, or any of them, as attorneys-in-fact, with full power of substitution, to execute in the name and on the behalf of each person, individually and in each capacity stated below, and to file, any and all amendments to this registration statement, including any and all post-effective amendments.

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities indicated and on August 5, 2025.

| Principal Executive Officer          |     | Directors                   |     |                                 |
| /s/ FRANK D. LEE                     |     | /s/ MARCELO BIGAL           |     | /s/ ABRAHAM CEESAY              |
| Frank D. Lee                         |     | Marcelo Bigal               |     | Abraham Ceesay