Company: SHPH
Filing Date: 2025-02-27
Form Type: 424B3
Source: 0001493152-25-008478
Chunk: 89

Company: Shuttle Pharmaceuticals Holdings, Inc.
Filing Date: 2025-02-27
Form: 424B3
Chunk 89
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 reporting. As part of our audits, we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures include examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

/s/ Forvis Mazars, LLP

We have served as the Company’s auditor since 2023.

Atlanta, Georgia

February 26, 2025

| F-1 |

<div align='center'>Shuttle Pharmaceuticals Holdings, Inc.

Consolidated Balance Sheets</div>

| Assets                                                                                                                                                                                      
 Current assets                                                                                                                                                                              |     | 2024                     
 Years Ended December 31, 
 2024                     |             |   |     | 2023 
 2023 |             |   |
|:--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|:----|:-------------------------|------------:|:--|:----|:-----|------------:|:--|
| Cash and cash equivalents                                                                                                                                                                   |     | $                        |   1,920,144 |   |     | $    |   2,576,416 |   |
| Prepaid expenses                                                                                                                                                                            |     |                          |     290,773 |   |     |      |     114,473 |   |
| Marketable securities                                                                                                                                                                       |     |                          |           — |   |     |      |   2,887,215 |   |
| Accrued interest income                                                                                                                                                                     |     |                          |           — |   |     |      |      14,901 |   |
| Total current assets                                                                                                                                                                        |     |                          |   2,210,917 |   |     |      |   5,593,005 |   |
| Property and equipment, net                                                                                                                                                                 |     |                          |      19,364 |   |     |      |      24,827 |   |
| Operating lease right-of-use asset                                                                                                                                                          |     |                          |     276,009 |   |     |      |     333,904 |