Company: SCLXW
Filing Date: 2025-05-15
Form Type: 424B3
Source: 0000950170-25-071904
Chunk: 121

Company: Scilex Holding Co
Filing Date: 2025-05-15
Form: 424B3
Chunk 121
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 of Jaisim Shah, Principal Executive Officer, and Stephen Ma, Principal Financial Officer, pursuant to Section 906 of the Sarbanes-Oxley Act of 2002. |
| 101.INS+       | Inline XBRL Instance Document.                                                                                                                                     |
| 101.SCH+       | Inline XBRL Taxonomy Extension Schema Document.                                                                                                                    |
| 101.CAL+       | Inline XBRL Taxonomy Extension Calculation Linkbase Document.                                                                                                      |
| 101.DEF+       | Inline XBRL Taxonomy Extension Definition Linkbase Document.                                                                                                       |
| 101.LAB+       | Inline XBRL Taxonomy Extension Labels Linkbase Document.                                                                                                           |
| 101.PRE+       | Inline XBRL Taxonomy Extension Presentation Linkbase Document.                                                                                                     |
| 104+           | Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101).                                                                          |

+ Filed herewith. ++ Furnished herewith. ^ Certain identified information has been omitted pursuant to Item 601(b)(10) of Regulation S-K because such information is both (i) not material and (ii) information that the Registrant treats as private or confidential. The Registrant hereby undertakes to furnish supplemental copies of the unredacted exhibit upon request by the SEC. 

# Certain of the exhibits and schedules to this Exhibit have been omitted in accordance with Regulation S-K Item 601. The Registrant agrees to furnish a copy of all omitted exhibits and schedules to the SEC upon its request.
<div align='center'>72</div>

SIGNAT URES Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

| May 14, 2025 | Scilex Holding Company |                                                                     |
|:-------------|:-----------------------|:--------------------------------------------------------------------|
|              | By:                    | /s/ Jaisim Shah                                                     |
|              |                        | Jaisim Shah                                                         
 Chief Executive Officer and President (Principal Executive Officer) |

| May 14, 2025 |     |                                                      |
|:-------------|:----|:-----------------------------------------------------|
|              | By: | /s/ Stephen Ma                                       |
|              |     | Stephen Ma                                           
 Chief Financial Officer(Principal Financial Officer) |

<div align='center'>73</div>

Exhibit 31.1 CERTIFICATION