Company: GHRS
Filing Date: 2025-02-05
Form Type: 424B5
Source: 0001140361-25-003183
Chunk: 13

Company: GH Research PLC
Filing Date: 2025-02-05
Form: 424B5
Chunk 13
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 -10,620 |     |     -10,620 |
| Accumulated deficit                                                         |     |                   -97,644 |     |     -97,644 |
| Total equity                                                                |     |                   189,366 |     |     329,166 |
| Total capitalization                                                        |     |                  $189,366 |     |    $329,166 |

| (1) | While we have not finalized our financial closing procedures as of and for the year ended December 31, 2024, we expect to report that, as of December 31, 2024, we had cash, cash equivalents, other financial assets and marketable securities of $182.6 million. This amount is unaudited and preliminary and is subject to completion of financial closing procedures. As a result, this amount may differ from the amount that will be reflected in our audited consolidated financial statements as of and for the year ended December 31, 2024. Our audited consolidated financial statements as of and for the year ended December 31, 2024 will not be available until after this offering is completed, and consequently will not be available to you prior to investing in this offering. The preliminary cash, cash equivalents, other financial assets and marketable securities included in this prospectus supplement has been prepared by, and is the responsibility of, the Company’s management. PricewaterhouseCoopers has not audited, reviewed, examined, compiled nor applied agreed-upon procedures with respect to the preliminary financial data. Accordingly, PricewaterhouseCoopers does not express an opinion or any other form of assurance with respect thereto. |

S-11

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### DILUTION
Net tangible book value per ordinary share is determined by dividing our tangible net worth (defined as total assets, less intangible assets, less total liabilities) by the number of our ordinary shares issued and outstanding.

Our historical net tangible book value as of September 30, 2024 was $189.4 million, or $3.64 per ordinary share. After giving effect to this offering and after deducting the underwriting discount and estimated offering expenses payable by us, our as adjusted net tangible book value as of September 30, 2024 would have been $329.2 million and our as adjusted net tangible book value per share as of September 30, 2024 would have been $5.31 per ordinary share (in each case assuming no exercise of the underwriters’ option to