Company: NCNA
Filing Date: 2025-06-27
Form Type: 424B5
Source: 0001193125-25-151464
Chunk: 17

Company: NuCana plc
Filing Date: 2025-06-27
Form: 424B5
Chunk 17
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 to be an “at the market offering” as defined in Rule
415(a)(4) under the Securities Act, including sales made directly on The Nasdaq Stock Market, on any other existing trading market for our ADSs or to or through a market maker.

Each time that we wish to issue and sell our ADSs under the Sales Agreement, we will provide the Sales Agents with a placement notice
describing the amount of shares to be sold, the time period during which sales are requested to be made, any limitation on the amount of ADSs that may be sold in any single day, any minimum price below which sales may not be made or any minimum
price requested for sales in a given time period and any other instructions relevant to such requested sales. Upon receipt of a placement notice, the Sales Agents will use commercially reasonable efforts, consistent with their normal trading and
sales practices and applicable state and federal laws, rules and regulations and the rules of The Nasdaq Stock Market, to sell our ADSs under the terms and subject to the conditions of the placement notice and the Sales Agreement. We or the Sales
Agents may suspend the offering of ADSs pursuant to a placement notice upon notice and subject to other conditions.

Settlement for sales
of ADSs, unless the parties agree otherwise, will occur on the first trading day following the date on which any sales are made in return for payment of the net proceeds to us. There are no arrangements to place any of the proceeds of this offering
in an escrow, trust or similar account. Sales of our ADSs as contemplated in this prospectus supplement will be settled through the facilities of The Depository Trust Company or by such other means as we and the Sales Agents may agree upon.

We will pay the Sales Agents commissions for their services in acting as our sales agent in the sale of our ADSs pursuant to the Sales
Agreement. The Sales Agents will be entitled to compensation at a fixed commission rate of 3.0% of the gross proceeds from the sale of our ADSs on our behalf pursuant to the Sales Agreement. We have also agreed to reimburse the Sales Agents for
their reasonable and documented out-of-pocket expenses (including but not limited to the reasonable and documented fees and expenses of their legal counsel) in an amount
not to exceed $55,000.

We estimate that the total expenses for this offering, excluding compensation payable to the Sales Agents and
certain expenses reimbursable to the Sales Agents under the terms of the Sales Agreement, will be approximately $425