Company: SCLXW
Filing Date: 2025-11-07
Form Type: DEF 14A
Source: 0001193125-25-272322
Chunk: 7

Company: Scilex Holding Co
Filing Date: 2025-11-07
Form: DEF 14A
Chunk 7
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 described at www.virtualshareholdermeeting.com/SCLX2025SM2.                                               |

If you plan to attend the Special Meeting, we recommend that you also vote by proxy so that your vote will be counted if you later decide not to attend the Special Meeting. If you are a street name stockholder, you will receive voting instructions from your broker, bank or other nominee. You must follow the voting instructions provided by your broker, bank or other nominee in order to direct your broker, bank or other nominee, as applicable, on how to vote your shares. Street name stockholders should generally be able to vote by returning a voting instruction form or on the Internet. However, the availability of Internet voting will depend on the voting process of your broker, bank or other nominee. As discussed above, if you are a street name stockholder, you must obtain a legal proxy from your broker, bank or other nominee in order to vote your shares by remote communication in the Special Meeting. Can I change my vote or revoke my proxy? Yes, if you are a stockholder of record, you can change your vote or revoke your proxy any time before the Special Meeting by:

| • |     | entering a new vote by Internet; |

| • |     | completing and returning a later-dated proxy card; |

| • |     | notifying our Corporate Secretary, in writing, at Scilex Holding Company, 960 San Antonio Road, Palo Alto, CA 
 94303; or                                                                                                     |

| • |     | attending and voting electronically at the Special Meeting (although attendance at the Special Meeting will not, 
 by itself, revoke a proxy).                                                                                      |

If you are a street name stockholder, your broker, bank or other nominee can provide you with instructions on how to change your vote. Will my vote be kept confidential? Yes, your vote will be kept confidential and not disclosed to the Company unless:

| • |     | required by law; |

| • |     | you expressly request disclosure on your proxy; or |

| • |     | there is a proxy contest. |

Why won’t there be an in-personmeeting? In order to provide expanded access to our stockholders, our Board has determined to hold a live audio webcast in lieu of an in-personmeeting. The virtual-only approach also lowers costs and aligns with our broader sustainability goals. Although no physical in-personmeeting will be held, we designed the format of the Special Meeting to ensure that our stockholders of record who attend the Special Meeting