Company: SCLXW
Filing Date: 2025-09-29
Form Type: 424B3
Source: 0001193125-25-221022
Chunk: 7

Company: Scilex Holding Co
Filing Date: 2025-09-29
Form: 424B3
Chunk 7
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 among the parties, written or oral, that may have related in any way to the subject matter of this Agreement. Any alterations or amendments to this Agreement (including any handwritten changes) will be null and void except by an instrument in writing, signed by both parties. [signature page follows] Page 2of 8

I NW ITNESSW HEREOF, this Agreement has been executed by the parties hereto through their duly authorized representatives as of the date first written above.

| SCILEX HOLDING COMPANY |     |                                       |     | INFORM LLC |     |                 |
| By:                    |     | /s/ Henry Ji                          |     | By:        |     | /s/ Jaisim Shah |
| Name:                  |     | Henry Ji                              |     | Name:      |     | Jaisim Shah     |
| Title:                 |     | Chief Executive Officer and President |     | Title:     |     | Consultant      |

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CONSULTING AGREEMENT TERMS AND CONDITIONS

T HESEC ONSULTINGA GREEMENTT ERMS ANDC ONDITIONS(the “Terms and Conditions”) are incorporated by reference into that certain Consulting Agreement (the “Agreement”) to which the Terms and Conditions are attached. All capitalized terms used but not defined
herein shall have the respective meanings as set forth in the Agreement.

1. S COPE OFS ERVICES.Consultant agrees to perform the Services in accordance with the Agreement.

2. C ONSULTANTR EPRESENTATIONS.Consultant represents and warrants that the following statements are true and correct as of the Effective Date and will continue to be true and correct for the duration of the Term: (a) Consultant and Consultant Key Person have the
requisite expertise and ability to perform the Services; (b) Consultant has full power, authority and right to enter into the Agreement, and perform its obligations thereunder, without the consent, approval or authorization of any third party,
such as Consultant Key Person’s employer; (c) Consultant is engaged as an independent contractor and has complied with all federal, state and local laws, including receipt of all applicable business permits and licenses required to
perform the Services; and (d) the execution, delivery and performance of the Agreement by Consultant does not constitute a breach of any contract, obligation or duty to which Consultant or Consultant Key Person is subject.

3. C ONFIDENTIALITY.Consultant agrees to (and will cause Consultant Key Person to