Company: SXTPW
Filing Date: 2025-02-06
Form Type: 424B5
Source: 0001213900-25-010772
Chunk: 0

Company: 60 DEGREES PHARMACEUTICALS, INC.
Filing Date: 2025-02-06
Form: 424B5
Chunk 0
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Filed Pursuant to Rule 424(b)(5)
Registration No. 333-280796

PROSPECTUS SUPPLEMENT

(To Prospectus dated July 12, 2024)

<div align='center'>1,503,500 Shares of Common Stock

60 Degrees Pharmaceuticals, Inc.</div>

We are offering 1,503,500 shares of our common
stock, par value $0.0001 per share, directly to certain institutional investors pursuant to this prospectus supplement and the accompanying
prospectus. The offering price is $0.715 per share.

Our common stock is listed on The Nasdaq Capital
Market under the symbol “SXTP.” On February 4, 2025, the last reported sale price of our common stock on The Nasdaq Capital
Market was $0.59.

In addition, we are offering 1,503,500 warrants
(the “Private Placement Warrants”) in a concurrent private placement, with each Warrant having the right to purchase one (1)
share of common stock. The Private Placement Warrants are exercisable immediately upon issuance and will expire twenty-four (24) months
from the issuance date. The Private Placement Warrants have an exercise price of $0.59 per share. The Private Placement Warrants and the
shares of common stock issuable upon the exercise of such warrants are not being registered under the Securities Act of 1933, as amended
(the “Securities Act”), and are not being offered pursuant to this prospectus supplement and the accompanying prospectus and
are being offered pursuant to an exemption from the registration requirements of the Securities Act provided in Section 4(a)(2) of the
Securities Act and Rule 506 of Regulation D promulgated thereunder.

The aggregate market value of our outstanding
shares of common stock held by non-affiliates, or public float, was approximately $12,355,544.24 based on 5,861,054 outstanding shares
of common stock as of February 5, 2025, of which approximately 5,590,744 shares are held by non-affiliates, and a per share price of $2.21,
based on the last sale price of our common stock on December 11, 2024, a date that is within 60 days of the date of this prospectus supplement.
During the 12 calendar months prior to and including the date of this prospectus supplement (but excluding this offering), we have sold
securities with