Company: PACB
Filing Date: 2025-08-07
Form Type: S-8
Source: 0001299130-25-000158
Chunk: 0

Company: PACIFIC BIOSCIENCES OF CALIFORNIA, INC.
Filing Date: 2025-08-07
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on August 7, 2025</div>

#### Registration No. 333-

### UNITED STATES

### SECURITIES AND EXCHANGE COMMISSION

#### Washington, D.C. 20549
<div align='center'>________________________________________________________________________________</div>

#### Form S-8
<div align='center'>REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

________________________________________________________________________________</div>

#### Pacific Biosciences of California, Inc.
<div align='center'>(Exact name of registrant as specified in its charter)

________________________________________________________________________________</div>

| Delaware                                 |     | 16-1590339         |
| (State or other jurisdiction of          
 incorporation or organization)           |     | -I.R.S. Employer   
 Identification No. |
| 1305 O’Brien Drive                       
 Menlo Park, CA 94025                     |     |                    |
| (Address of principal executive offices) |     |                    |

<div align='center'>Pacific Biosciences of California, Inc. 2020 Equity Incentive Plan

(Full title of the plan)</div>

#### Christian O. Henry

#### Chief Executive Officer and President

#### 1305 O’Brien Drive

#### Menlo Park, CA 94025
<div align='center'>(Name and address of agent for service)

(650) 521-8000

(Telephone number, including area code, of agent for service)

Copies to:</div>

#### Andrew D. Hoffman

#### Zachary B. Myers

#### Wilson Sonsini Goodrich & Rosati, P.C.

#### 650 Page Mill Road

#### Palo Alto, CA 94304
<div align='center'>(650) 493-9300</div>

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

| Large accelerated filer |     | o |     | Accelerated filer         |     | x |
| Non-accelerated filer   |     | o |     | Smaller reporting company |     | o |
|                         |     |   |     | Emerging growth company   |