Company: FENC
Filing Date: 2025-11-18
Form Type: S-8
Source: 0001104659-25-113660
Chunk: 1

Company: FENNEC PHARMACEUTICALS INC.
Filing Date: 2025-11-18
Form: S-8
Chunk 1
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If an emerging growth company, indicate by check mark if the
registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards
provided pursuant to Section 7(a)(2)(B) of the Securities Act. ¨

<div align='center'>PART I

INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS</div>

Item 1. Plan Information.*

Item 2. Registrant Information and Employee Plan Annual Information.*

*The documents containing
the information specified in this Part I will be sent or given to participants as specified by Rule 428(b)(1) under the
Securities Act of 1933, as amended (the “Securities Act”). In accordance with the rules and regulations of the U.S.
Securities and Exchange Commission (the “Commission”) and the instructions to Form S-8, such documents are not being
filed with the Commission either as part of this Registration Statement or as prospectuses or prospectus supplements pursuant to Rule 424
under the Securities Act. These documents and the documents incorporated by reference in the registrant statement pursuant to Item 3
of Part II of this Form S-8, taken together, constitute a prospectus that meets the requirements of Section 10(a) of
the Securities Act.

<div align='center'>PART II

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT</div>

Item 3. Incorporation of Documents by Reference.

The following documents,
which Fennec Pharmaceuticals Inc. (the “Company”, the “Registrant”, “Fennec”, “we”, “us”
or “our”) has filed with the Commission are incorporated herein by reference:

1. our Annual Report on Form 10-K for the year ended December 31, 2024 (the “Form 10-K”), filed with the Commission on March 26, 2025;

2. the information specifically
incorporated by reference into our Form 10-K from our Definitive Proxy Statement on Schedule 14A, filed with the Comission on April 25, 2025;

3. our Quarterly Reports
on Form 10-Q for the quarters ended March 31, 2025, June 30, 2025, and September 30, 2025, filed with the Commission on May 14, 2025, August 14, 2025, and November 13, 2025, respectively;

4. our Current Reports