Company: TAK
Filing Date: 2025-06-27
Form Type: 424B2
Source: 0001628280-25-033198
Chunk: 18

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-27
Form: 424B2
Chunk 18
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FI Indenture and the Trust Indenture Act for a statement thereof.

#### Status of the Notes
The Notes will be the Issuer’s direct, unsecured and unsubordinated general obligations and will have the same rank in liquidation as all of the Issuer’s other unsecured and unsubordinated debt.

#### Principal and Maturity
The initial aggregate principal amount of the Notes is as follows:

• For the 2035 Notes, $1,650,000,000; and

• For the 2055 Notes, $750,000,000.

The Notes will mature on the following dates:

• For the 2035 Notes, July 7, 2035; and

• For the 2055 Notes, July 7, 2055.

<div align='center'>S-14</div>

Principal will be repaid at maturity at a price of 100% of the principal amount of the Notes. The Notes will not be redeemable prior to maturity, except as set forth below under “—Redemption,” and will not be subject to any sinking fund.

#### Interest
Interest on the Notes will accrue at the following rates:

• For the 2035 Notes: 5.200% per annum; and

• For the 2055 Notes: 5.900% per annum.

The Issuer will pay interest on the Notes semi-annually in arrears on January 7 and July 7 of each year (each an interest payment date), beginning on January 7, 2026. The Issuer will pay interest to the holders of record of the Notes on the day ten business days preceding such interest payment date, as applicable. Interest on the Notes will be paid to but excluding the relevant interest payment date. Interest on the Notes will accrue from the date of original issuance or, if interest has already been paid, from the date it was most recently paid. Interest on the Notes will be computed on the basis of a 360-day year consisting of twelve 30-day months.

If any date for payment of principal or interest (or additional amounts, if any) falls on a day that is not a business day, then payment of principal or interest (or additional amounts, if any) need not be made on such date but may be made on the next succeeding business day. Any payment made on such next succeeding business day shall have the same force and effect as if made on the due date, and no interest shall accrue with respect to such payment