Company: SCLXW
Filing Date: 2025-05-07
Form Type: POS AM
Source: 0001193125-25-115095
Chunk: 565

Company: Scilex Holding Co
Filing Date: 2025-05-07
Form: POS AM
Chunk 565
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 to be done in and about the premises, as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorney-in-factand agent, or his substitute or substitutes, may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act, this Post-Effective Amendment No. 3 to the registration statement has been signed by the following persons in the capacities and on the dates indicated.

| Signature                                           
 /s/ Jaisim Shah Jaisim Shah                         
 /s/ Stephen Ma Stephen Ma                           |     | Title                                                                         
 Chief Executive Officer, President and Director (Principal Executive Officer) 
 Chief Financial Officer                                                       
 (Principal Financial and Accounting Officer)                                  |     | Date        
 May 7, 2025 
 May 7, 2025 |
|:----------------------------------------------------|:----|:------------------------------------------------------------------------------|:----|:------------|
| /s/ Henry Ji, Ph.D. Henry Ji, Ph.D.                 |     | Executive Chairperson and Director                                            |     | May 7, 2025 |
| /s/ Dorman Followwill Dorman Followwill             |     | Director                                                                      |     | May 7, 2025 |
| /s/ Yue Alexander Wu, Ph.D. Yue Alexander Wu, Ph.D. |     | Director                                                                      |     | May 7, 2025 |
| /s/ Jay Chun, M.D., Ph.D. Jay Chun, M.D., Ph.D.     |     | Director                                                                      |     | May 7, 2025 |
| /s/ Annu Navani, M.D. Annu Navani, M.D.             |     | Director                                                                      |     | May 7, 2025 |

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