Company: APM
Filing Date: 2025-12-05
Form Type: 424B5
Source: 0001213900-25-118752
Chunk: 7

Company: Aptorum Group Ltd
Filing Date: 2025-12-05
Form: 424B5
Chunk 7
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 by Nasdaq, and an act passed by the U.S. Senate and the U.S. House of Representatives, all call for additional and more stringent criteria to be applied to emerging market companies. These developments could add uncertainties to our offering, business operations, share price and reputation.”for more information.

The interpretation and enforcement of PRC laws
and regulations could limit the legal protection available to you and us, hinder our ability to offer or continue to offer the Class A
Ordinary Shares, result in a material adverse effect on our business operations, and damage our reputation, which might further cause
the Class A Ordinary Shares to significantly decline in value or become worthless. See “Risk Factors — Risks Related
to Doing Business in Hong Kong,” the section “Our Company” in the Prospectus Summary and “Permission Required
from the PRC Authorities” in the Regulation section.

Investing in our securities involves a high degree of risk. See “Risk Factors” beginning on page 23 of this prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is December 5, 2025

TABLE OF CONTENTS</div>

|                                                                         | Page |
| Special Note Regarding Forward-Looking Statements                       |   ii |
| Commonly Used Defined Terms                                             |  iii |
| Industry and Market Data                                                |  vii |
| Prospectus Summary                                                      |    1 |
| Offering Summary                                                        |   22 |
| Risk Factors Related to the DiamiR Merger and Aptorum                   |   23 |
| Trademarks, Service Marks and Tradenames                                |   96 |
| Use of Proceeds                                                         |   96 |
| Dividend Policy                                                         |   97 |
| Capitalization                                                          |   98 |
| Quantitative And Qualitative Disclosures About Market Risk              |   99 |
| Operating And Financial Review And Prospects                            |  100 |
| Company’s Business                                                      |  113 |
| DiamiR’s Business                                                       |  157 |
| Management                                                              |  191 |
| DiamiR’s Management                                                     |  197 |
| Transactions With Related Persons                                       |  207 |
| DiamiR’s Transactions with Related Persons                              |  209 |
| Security Ownership Of Certain Beneficial Owners And Management          |  209 |
|