Company: APM
Filing Date: 2025-11-17
Form Type: F-1
Source: 0001213900-25-111548
Chunk: 290

Company: Aptorum Group Ltd
Filing Date: 2025-11-17
Form: F-1
Chunk 290
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 11/10/2020 Title: Circulating brain-enriched microRNAs as peripheral biomarkers of neurodegeneration. 177 The main goal of this project is to assess associations between circulating brain-enriched microRNAs and known AD markers in preclinical AD samples from A4 prevention study. NIH/NIA SBIR Phase II Grant Number 2R44AG044860-02 02/15/2015 – 01/31/2017 Title: Early detection of Alzheimer’s (MCI stage): Analysis of plasma cell-free miRNA. The goal of this Phase II study was to provide further validation for the MCI microRNA signature using plasma samples from well-characterized heterogeneous cohorts and to define microRNA biomarker signatures for predicting AD “progressors” and for differentiating AD from other neurodegenerative diseases. NIH/NIA SBIR Phase I Grant Number 1R43AG053116-01 06/01/2016 – 11/30/2016 Title: Circulating organ-enriched microRNAs as biomarkers of aging The goal of this study was to analyze brain-enriched microRNA signatures detectable in plasma in the context of normal aging; the study was conducted in collaboration with the New York Blood Center. Rett Syndrome Research Trust (2014 and 2015 awards) 12/01/2014 – 04/30/2016 Title: Analysis of circulating brain-enriched microRNAs as biomarkers for Rett Syndrome. The goal of this study was to assess brain-enriched microRNA biomarkers in plasma samples of Mecp2 deficient male and female mice and controls. NIH/NIA SBIR Phase I Grant Number 1R43AG044860-01 07/01/2013 – 12/31/2013 Title: Early detection of Alzheimer’s disease at MCI stage by analysis of cell-free miRNA in plasma. The goal of this study was to assess feasibility of detecting MCI patients who would progress to AD dementia and to identify microRNA biomarker candidates for differentiating Alzheimer’s disease from Parkinson’s disease. The Michael J. Fox Foundation for Parkinson’s Research Grant Number 9477 2014 Title: Analysis of circulating brain-enriched microRNAs as biomarkers for Parkinson’s disease. The goal of this study was to test microRNA biomarker candidates using plasma samples collected from Parkinson’s disease patients and age-matched controls from the BioFIND clinical study. IRS-QTDP