Company: APM
Filing Date: 2025-10-14
Form Type: 424B5
Source: 0001213900-25-098635
Chunk: 106

Company: Aptorum Group Ltd
Filing Date: 2025-10-14
Form: 424B5
Chunk 106
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 securities; or |

| ● | reducing the percentage of debt securities, the holders of                          
 which are required to consent to any amendment, supplement, modification or waiver. |

Discharge

Each indenture provides that
we can elect to be discharged from our obligations with respect to one or more series of debt securities, except that the following obligations,
among others survive until the maturity date or the redemption date:

| ● | register the transfer or exchange of debt securities of the 
 series;                                                     |

| ● | replace stolen, lost or mutilated debt securities of the series; |

| ● | maintain paying agencies; |

| ● | hold monies for payment in trust; and |

| ● | appoint any successor trustee; |

and the following obligations
survive the maturity date or the redemption date:

| ● | recover excess money held by the debenture trustee; and |

| ● | compensate and indemnify the debenture trustee. |

<div align='center'>22</div>

As more fully set forth in
the indentures, in order to exercise our rights to be discharged, we must either deliver for cancellation all securities of a series to
the debenture trustee or must deposit with the debenture trustee money or government obligations sufficient to pay all the principal of,
any premium, if any, and interest on, the debt securities of the series on the dates payments are due.

Form, Exchange and Transfer

We will issue the debt securities
of each series only in fully registered form without coupons and, unless we otherwise specify in the applicable prospectus supplement,
in denominations of $1,000 and any integral multiple thereof. The indentures provide that we may issue debt securities of a series in
temporary or permanent global form and as book-entry securities that will be deposited with, or on behalf of, The Depository Trust Company,
New York, New York, known as DTC, or another depositary named by us and identified in a prospectus supplement with respect to that series.

At the option of the holder,
subject to the terms of the indentures and the limitations applicable to global securities described in the applicable prospectus supplement,
the holder of the debt securities of any series can exchange the debt securities for other debt securities of the same series, in any
authorized denomination and of like tenor and aggregate principal amount.

Subject to the terms of the
indentures and the limitations applicable to global securities set forth in the applicable prospectus supplement, holders of the debt
securities may present the debt securities