Company: AZN
Filing Date: 2025-06-26
Form Type: 11-K
Source: 0001683168-25-004771
Chunk: 15

Company: ASTRAZENECA PLC
Filing Date: 2025-06-26
Form: 11-K
Chunk 15
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,223 | ) |     | $ |    10,779,307 | ) |
| Net assets available for benefits per the Form 5500                                                                          |     | $ | 8,644,002,344 |   |     | $ | 7,599,332,410 |   |

The following is a reconciliation of the change in net assets
available for benefits for the year ended December 31, 2024, per the financial statements to the net income reported in the 2024
Form 5500:

| Net increase in net assets available for benefits per financial statements                                                                           |     | $ | 1,043,439,850 |   |
| Adjustment from contract value to fair value for fully-benefit responsive investment contracts held by the Stable Value Fund as of December 31, 2024 |     |   |    (9,549,223 | ) |
| Adjustment from contract value to fair value for fully-benefit responsive investment contracts held by the Stable Value Fund as of December 31, 2023 |     |   |  10,779,30730 |   |
| Net increase in net assets available for benefits per Form 5500                                                                                      |     | $ | 1,044,669,934 |   |

| 14 |

<div align='center'>ASTRAZENECA SAVINGS AND SECURITY PLAN

Notes to Financial Statements

December 31, 2024 and 2023

_______________</div>

| 11. | Subsequent Events: |

The
Plan has evaluated subsequent events through June 24, 2025, the date the financial statements were available to be issued, and noted
the following:

Plan
Amendment No. 4 was executed on December 17, 2024 to merge the assets for Neogene Therapeutics, Inc. and the participation of its employees
into the Plan effective January I, 2025. Effective on or about January 10, 2025, the portion of the Insperity 401(k) Plan attributable
to employees of Neogene Therapeutics, Inc. was merged into the Plan.

Plan Amendment No. 5 was executed on April 9, 2025 to merge the GraccellBio
401(k) Plan with and into the Plan effective on or about May 6, 2025.

| 15 |

<div align='center'>SUPPLEMENTAL SCHEDULE

ASTRAZENECA SAVINGS AND SECURITY PLAN

Schedule H