Company: DNLI
Filing Date: 2025-02-27
Form Type: S-3ASR
Source: 0001628280-25-008647
Chunk: 45

Company: Denali Therapeutics Inc.
Filing Date: 2025-02-27
Form: S-3ASR
Chunk 45
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 4.2 above. |     |       |     |            |     |         |     |                |
| 107.1          |     | Filing Fee Table.                                                                                                                                      |     | —     |     | —          |     |       — |     | Filed herewith |

________________________

| *  |     | To be filed by amendment or incorporated by reference in connection with the offering of the securities.                                                                                    |
| ** |     | To be filed pursuant to Section 305(b)(2) of the Trust Indenture Act of 1939.                                                                                                               |
| 

#  |     | Certain confidential information contained in this exhibit has been omitted because it is both (i) not material and (ii) is the type that the Registrant treats as private or confidential. |
<div align='center'>II - 6</div>

### SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of South San Francisco, State of California, on the 27th day of February, 2025.

| DENALI THERAPEUTICS INC. |     |                                       |
| By:                      |     | /s/ Ryan J. Watts                     |
|                          |     | Ryan J. Watts, Ph.D.                  |
|                          |     | President and Chief Executive Officer |

### POWER OF ATTORNEY
KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Ryan J. Watts, Ph.D. and Alexander O. Schuth, M.D. or either of them, as his or her true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to file and sign any and all amendments, including post-effective amendments and any registration statement for the same offering that is to be effective under Rule 462(b) of the Securities Act, as amended, to this registration statement, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, full power and authority to do and perform each and every act and thing requisite and necessary to be done