Company: TEM
Filing Date: 2025-08-08
Form Type: S-3ASR
Source: 0001193125-25-175993
Chunk: 71

Company: Tempus AI, Inc.
Filing Date: 2025-08-08
Form: S-3ASR
Chunk 71
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 at which our Class A common stock is sold in this offering and the total amount of sales of Class A common stock in this offering.      |

| Plan of Distribution | “At the market offering” that may be made from time to time through or to Morgan Stanley, Cantor, TD Securities and/or Allen as sales agent or principal. See “Plan of Distribution.” |

| Use of Proceeds | We intend to use the net proceeds from the sale of the securities under this prospectus for general corporate purposes, which may include acquisitions or strategic investments in complementary businesses or technologies, working capital, 
 operating expenses and capital expenditures. See “Use of Proceeds.”                                                                                                                                                                           |

| Risk Factors | Investing in our Class A common stock involves a high degree of risk. Before deciding whether to invest in our Class A common stock, please read the information contained under the heading “Risk Factors” and in the section title           
 “Risk Factors” contained in our most recent Annual Report on Form 10-K and subsequent Quarterly Reports on Form 10-Q, as well as any amendments thereto reflected in subsequent filings with the SEC, which are incorporated by reference into 
 this prospectus in their entirety.                                                                                                                                                                                                             |

3

| Nasdaq Global Select Trading Symbol | “TEM” |

The number of shares of Class A common stock and Class B common stock that will be outstanding immediately after this offering is based on 168,580,827 shares of Class A common stock and 5,043,789 shares of Class B common stock outstanding as of June 30, 2025 and excludes:

| • |     | 3,122,720 shares of Class A common stock issuable on the vesting and settlement of restricted stock units 
 outstanding as of June 30, 2025 under our 2015 Equity Incentive Plan (“2015 EIP”);                        |

| • |     | 3,693,885 shares of Class A common stock issuable on the vesting and settlement of restricted stock units and  
 restricted stock awards outstanding as of June 30, 2025 under our 2024 Equity Incentive Plan (the “2024 EIP”); |

| • |     | 6,355,699 shares of our Class A common stock reserved for future issuance under the 2024 EIP; |

| • |     | 3,000,000 shares of Class A common stock reserved for future issuance under our 2024 Employee Stock Purchase Plan 
 (“2024 ESPP”);