Company: HURA
Filing Date: 2025-12-10
Form Type: 424B5
Source: 0001193125-25-313799
Chunk: 39

Company: TuHURA Biosciences, Inc./NV
Filing Date: 2025-12-10
Form: 424B5
Chunk 39
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 as “defeasance”; or                                                                                                                                                |

| • |     | we will no longer be under any obligation to comply with certain covenants under the applicable indenture as it               
 relates to that series, and some events of default will no longer apply to us, which is referred to as “covenant defeasance.” |

Unless the applicable prospectus supplement specifies otherwise and except as described below, the conditions to both defeasance and covenant defeasance are as follows:

| • |     | it must not result in a breach or violation of, or constitute a default or event of default under, the applicable                     
 indenture, or result in a breach or violation of, or constitute a default under, any other of our material agreements or instruments; |

| • |     | certain bankruptcy-related defaults or events of default with respect to us must not have occurred and be                                                       
 occurring during the period commencing on the date of the deposit of the trust funds to defease the debt securities and ending on the 91st day after that date; |

| • |     | we must deliver to the trustee an officer’s certificate and an opinion of counsel addressing compliance 
 with the conditions of the defeasance or covenant defeasance; and                                       |

| • |     | we must comply with any additional conditions to the defeasance or covenant defeasance that the applicable 
 indenture may impose on us.                                                                                |

In the event that government obligations deposited with the trustee for the defeasance of such debt securities decrease in value or default subsequent to their being deposited, we will have no further obligation, and the holders of the debt securities will have no additional recourse against us, for any decrease in value or default. If indicated in the prospectus supplement, in addition to obligations of the U.S. or an agency or instrumentality of the U.S., government obligations may include obligations of the government or an agency or instrumentality of the government issuing the currency in which debt securities of such series are payable. We may exercise our defeasance option for the debt securities even if we have already exercised our covenant defeasance option. If we exercise our defeasance option, payment of the debt securities may not be accelerated because of default or an event of default. If we exercise our covenant defeasance option, payment of the debt securities may not be accelerated because of default or an event of default with respect to the covenants to which the covenant defeasance is applicable. If, however, acceleration occurs,