Company: SCLXW
Filing Date: 2025-11-04
Form Type: 424B3
Source: 0001193125-25-264325
Chunk: 4

Company: Scilex Holding Co
Filing Date: 2025-11-04
Form: 424B3
Chunk 4
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 a five-percent (5%) royalty on net sales of the Product (as defined therein) during the applicable royalty term under the License Agreement. The License Agreement contains customary reciprocal indemnification obligations for Datavault and the Company and customary representations and warranties. The foregoing is a summary of the material terms of the License Agreement and does not purport to be complete and is qualified in its entirety by reference to the full text of the License Agreement, a copy of which is filed herewith as Exhibit 10.1 and is incorporated herein by reference. Item 7.01. Regulation FD Disclosure On November 4, 2025, the Company issued a press release announcing the entry into the License Agreement, a copy of which is attached as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference. The information furnished pursuant to Item 7.01 on this Current Report on Form 8-K, including Exhibit 99.1 attached hereto, shall not be deemed “filed” for purposes of Section 18 of the Exchange Act, or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act or the Exchange Act, except as expressly provided by specific reference in such a filing. Item 9.01. Financial Statements and Exhibits. (d) Exhibits.

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| 99.1 | Press release, dated November 4, 2025.                                                                |
|:-----|:------------------------------------------------------------------------------------------------------|
| 104  | Cover Page Interactive Data File, formatted in Inline Extensible Business Reporting Language (iXBRL). |

* Certain of the exhibits and schedules to this Exhibit have been omitted in accordance with Regulation S-K Item 601(a)(5). The Registrant agrees to furnish a copy of all omitted exhibits and schedules to the SEC upon its request.

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SIGNATURES Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

|                        | SCILEX HOLDING COMPANY |                                     |
|                        | By:                    | /s/ Henry Ji                        |
|                        | Name:                  | Henry Ji                            |
| Date: November 4, 2025 | Title:                 | Chief Executive Officer & President |

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EXCLUSIVE LICENSE AGREEMENT</div>

This License