Company: SNY
Filing Date: 2025-10-27
Form Type: 424B5
Source: 0001193125-25-250786
Chunk: 85

Company: Sanofi
Filing Date: 2025-10-27
Form: 424B5
Chunk 85
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 used to determine the amount of payment of principal of, premium, if any, and interest on the series of 
 debt securities;                                                                                                  |

| • |     | any amendment to or removal of the covenant to pay additional amounts for withholding taxes or other governmental 
 charges and the related right to an optional tax redemption for such a series;                                    |

| • |     | any additional events of default or covenants or other provisions applicable to the series of debt securities, or 
 any that are not applicable;                                                                                      |

| • |     | whether the series of debt securities will be issuable in whole or in part in the form of a global security as                          
 described under “Legal Ownership — Global Securities,” and the depositary or its nominee with respect to the series of debt securities; |

| • |     | a discussion of material U.S. federal income tax considerations; and |

| • |     | any terms and conditions of the series of debt securities, which may be different from those described in the 
 prospectus. (Section 301)                                                                                     |

12

In this description of debt securities “you” means direct holders and not street name or other indirect holders of debt securities. Indirect holders should read the section “Legal Ownership — Street Name and Other Indirect Holders.” Additional Mechanics Exchange and Transfer The debt securities will be issued:

| • |     | in fully registered form; |

| • |     | without interest coupons; and |

| • |     | in denominations that are indicated in the prospectus supplement. |

Unless otherwise specified in the prospectus supplement, the debt securities will be issued in the form of one or more global certificates in registered form that will be deposited with a depositary, such as The Depository Trust Company, Euroclear Bank S.A./N.V. or Clearstream Banking, société anonyme , as specified in the applicable prospectus supplement. See “Legal Ownership — Global Securities” for more information. Payment and Paying Agents We will pay interest to you if you are a direct holder listed in the trustee’s records at the close of business on a particular day in advance of each due date for interest, even if you no longer own the debt security on the interest due date. That particular day is called the regular record date and is stated in the prospectus supplement. ( Section 307) We will pay interest, principal and any other money due on the registered debt securities at the trustee’s corporate trust office. That office is currently located at Deutsche Bank Trust Company Americas