Company: XXII
Filing Date: 2025-08-26
Form Type: 424B5
Source: 0001641172-25-025541
Chunk: 26

Company: 22nd Century Group, Inc.
Filing Date: 2025-08-26
Form: 424B5
Chunk 26
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 manner in which our securities may be offered using this prospectus. We will provide specific terms of the securities, including the offering prices, in one or more supplements to this prospectus. The supplements may also add, update or change information contained in this prospectus. You should read this prospectus and the prospectus supplement relating to the specific issue of securities carefully before you invest.

We may offer the securities for sale directly to the purchasers or through one or more underwriters, dealers and agents to be designated at a future date. The supplements to this prospectus will provide the specific terms of the plan of distribution.

Our common stock is listed on the Nasdaq Capital Market under the symbol “XXII.” The last reported sale price of the common stock on March 6, 2023 was $0.9356 per share. Each prospectus supplement will indicate if the securities offered thereby will be listed on any securities exchange.

Investing in our securities involves risk. Please read carefully the section entitled “Risk Factors” on Page 1 of this prospectus and any similar section contained in the applicable prospectus supplement and/or other offering material concerning factors you should consider before investing in our securities which may be offered hereby.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

<div align='center'>The date of this prospectus is March 31, 2023.</div>

<div align='center'>TABLE OF CONTENTS</div>

| ABOUT                            
 THIS PROSPECTUS                  |  1 |
| RISK                             
 FACTORS                          |  1 |
| “FORWARD-LOOKING”                
 INFORMATION                      |  1 |
| 22ND                             
 CENTURY GROUP, INC.              |  3 |
| USE                              
 OF PROCEEDS                      |  4 |
| DILUTION                         |  5 |
| SECURITIES                       
 TO BE OFFERED                    |  6 |
| DESCRIPTION                      
 OF DEBT SECURITIES               |  7 |
| DESCRIPTION                      
 OF CAPITAL STOCK                 | 13 |
| DESCRIPTION                      
 OF WARRANTS                      | 17 |
| DESCRIPTION                      
 OF SUBSCRIPTION RIGHTS           | 18 |
| DESCRIPTION                      
 OF SECURITIES PURCHASE CONTRACTS | 19 |
| DESCRIPTION                      
 OF UNITS                         | 20 |
| PLAN                             
 OF DISTRIBUTION                  | 21 |
| WHERE                            
 YOU CAN FIND MORE INFORMATION    |