Company: FITBI
Filing Date: 2025-10-09
Form Type: 425
Source: 0001193125-25-234729
Chunk: 5

Company: FIFTH THIRD BANCORP
Filing Date: 2025-10-09
Form: 425
Chunk 5
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 Agreement or such other date as is specified in the Merger Agreement. Moreover, information concerning the subject matter of the representations and warranties may
change

after the date of the Merger Agreement, which subsequent information may or may not be fully reflected in the parties’ public disclosures. Accordingly, the Merger Agreement is included with this filing only to provide investors with information regarding the terms of the Merger Agreement, and not to provide investors with any other factual information regarding Fifth Third, Comerica, their respective affiliates or their respective businesses. The Merger Agreement should not be read alone, but should instead be read in conjunction with the other information regarding Fifth Third, Comerica, their respective affiliates or their respective businesses, the Merger Agreement, the Mergers and the Bank Mergers that will be contained in, or incorporated by reference into, the Registration Statement on Form S-4that will include a joint proxy statement of Fifth Third and Comerica and a prospectus of Fifth Third, as well as in the Annual Reports on Form 10-K,Quarterly Reports on Form 10-Q,Current Reports on Form 8-Kand other filings that each of Fifth Third and Comerica makes with the Securities and Exchange Commission (the “SEC”). The foregoing description of the Merger Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Merger Agreement, which is attached hereto as Exhibit 2.1 and is incorporated herein by reference. Item 9.01 Financial Statements and Exhibits. (d) Exhibits

| Exhibit No. 
 2.1*        |     | Description                                                                                                                                                                               
 Agreement and Plan of Merger, dated as of October 5, 2025, by and among Fifth Third Bancorp, Fifth Third Financial Corporation, Comerica Incorporated and Comerica Holdings Incorporated. |
|:------------|:----|:------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 104         |     | Cover Page Interactive Data File (embedded within the Inline XBRL document).                                                                                                              |

| * | Schedules have been omitted pursuant to Item 601(a)(5) of Regulation                                                                                                                                                                                                           
 S-K. A copy of any omitted schedule will be furnished supplementally to the SEC upon request; provided, however, that the parties may request confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934, as amended, for any document so furnished. |

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