Company: RCUS
Filing Date: 2025-10-31
Form Type: 424B5
Source: 0001193125-25-260836
Chunk: 70

Company: Arcus Biosciences, Inc.
Filing Date: 2025-10-31
Form: 424B5
Chunk 70
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 instead deal only with the depositary that holds the global security. If securities are issued only in the form of a global security, an investor should be aware of the following:

| • |     | an investor cannot cause the securities to be registered in his or her name, and cannot obtain non-global   
 certificates for his or her interest in the securities, except in the special situations we describe below; |

| • |     | an investor will be an indirect holder and must look to his or her own bank or broker for payments on the 
 securities and protection of his or her legal rights relating to the securities, as we describe above;    |

| • |     | an investor may not be able to sell interests in the securities to some insurance companies and to other 
 institutions that are required by law to own their securities in non-book-entry form;                    |

| • |     | an investor may not be able to pledge his or her interest in a global security in circumstances where                                                
 certificates representing the securities must be delivered to the lender or other beneficiary of the pledge in order for the pledge to be effective; |

| • |     | the depositary’s policies, which may change from time to time, will govern payments, transfers, exchanges 
 and other matters relating to an investor’s interest in a global security;                                |

| • |     | we and any applicable trustee have no responsibility for any aspect of the depositary’s actions or for its                    
 records of ownership interests in a global security, nor do we or any applicable trustee supervise the depositary in any way; |

| • |     | the depositary may, and we understand that DTC will, require that those who purchase and sell interests in a                                
 global security within its book-entry system use immediately available funds, and your broker or bank may require you to do so as well; and |

| • |     | financial institutions that participate in the depositary’s book-entry system, and through which an                                                          
 investor holds its interest in a global security, may also have their own policies affecting payments, notices and other matters relating to the securities. |

There may be more than one financial intermediary in the chain of ownership for an investor. We do not monitor and are not responsible for the actions of any of those intermediaries. Special Situations When a Global Security Will Be Terminated In a few special situations described below, the global security will terminate and interests in it will be exchanged for physical certificates representing those interests. After that exchange, the choice of whether to hold securities directly