Company: NCNA
Filing Date: 2025-05-05
Form Type: CORRESP
Source: 0001193125-25-112629
Chunk: 0

Company: NuCana plc
Filing Date: 2025-05-05
Form: CORRESP
Chunk 0
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May 5, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549

| Re: | NuCana plc |

Registration Statement on Form F-1,as amended File No. 333-286737 Request for Acceleration of Effective Date Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended (the “ Securities Act”), Laidlaw & Company (UK) Ltd., as placement agent, hereby joins in the request of NuCana plc for acceleration of the effective date of the above-referenced registration statement on Form F-1,as amended (the “ Registration Statement”), so that it becomes effective as of 5:00 p.m. Eastern Time on Monday, May 5, 2025, or as soon thereafter as possible. Pursuant to Rule 460 of the General Rules and Regulations of the Securities Act, please be advised that there will be distributed to each placement agent, who is reasonably anticipated to be invited to participate in the distribution of the security, as many copies of the proposed form of preliminary prospectus as appears to be reasonable to secure adequate distribution of the preliminary prospectus. The undersigned has and will comply, and it has been informed or will be informed by any participating dealers that they have complied or will comply, with the requirements of Rule 15c2-8under the Securities Exchange Act of 1934, as amended. [Signature Page to Follow]

| Very truly yours,           |     |                         |
| LAIDLAW & COMPANY (UK) LTD. |     |                         |
| By:                         |     | /s/ Luke Kottke         |
| Name:                       |     | Luke Kottke             |
| Title:                      |     | Head of Capital Markets |

[Signature Page to Placement Agent’s Acceleration Request]