Company: JPC
Filing Date: 2025-06-10
Form Type: N-14 8C/A
Source: 0001999371-25-007489
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Company: Nuveen Preferred & Income Opportunities Fund
Filing Date: 2025-06-10
Form: N-14 8C/A
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<div align='center'>As filed with the Securities and Exchange Commission on June 9, 2025</div>

File No. 333-286736

<div align='center'>UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM N-14

REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933

☒ Pre-Effective
Amendment No. 1

☐ Post-Effective
Amendment No. __

NUVEEN PREFERRED & INCOME OPPORTUNITIES FUND

(Exact Name of Registrant as Specified in Charter)

333 West Wacker Drive
Chicago, Illinois 60606
(Address of Principal Executive Offices: Number, Street, City, State, Zip Code)

(800) 257-8787
(Area Code and Telephone Number)

Mark L. Winget
Vice President and Secretary
Nuveen Investments
333 West Wacker Drive
Chicago, Illinois 60606(Name and Address of Agent for Service)

Copies to:</div>

| Deborah Bielicke Eades   
 Vedder Price P.C.        
 222 North LaSalle Street 
 Chicago, Illinois 60601  | Eric F. Fess                       
 Chapman and Cutler LLP             
 320 South Canal Street, 27th Floor 
 Chicago, Illinois 60606            |

Approximate Date of Proposed Public Offering: As soon as practicable
after the effective date of this Registration Statement.

The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until this Registration Statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.

<div align='center'>IMPORTANT NOTICE TO SHAREHOLDERS OF
NUVEEN PREFERRED SECURITIES & INCOME OPPORTUNITIES FUND (JPI)
AND
NUVEEN PREFERRED & INCOME OPPORTUNITIES FUND (JPC)
(EACH, A “FUND” AND TOGETHER, THE “FUNDS”)

[●], 2025</div>

Although we recommend that you read the complete Joint Proxy Statement/Prospectus, for your convenience, we have provided a brief overview of the proposals to be voted