Company: RCUS
Filing Date: 2025-02-18
Form Type: 424B5
Source: 0001193125-25-028669
Chunk: 73

Company: Arcus Biosciences, Inc.
Filing Date: 2025-02-18
Form: 424B5
Chunk 73
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or replace such earlier statements. We will furnish without charge to each person, including any beneficial owner, to whom a prospectus is delivered, upon written or oral request, a copy of any or all of the documents incorporated by reference into
this prospectus but not delivered with the prospectus, including exhibits that are specifically incorporated by reference into such documents. You should direct any requests for documents to:

Arcus Biosciences, Inc.

Attn:
Corporate Secretary

3928 Point Eden Way

Hayward, CA 94545

(510) 694-6200

29

13,636,364 Shares Common Stock PROSPECTUS SUPPLEMENT

| Goldman Sachs & Co. LLC |     | Leerink Partners |     | Evercore ISI |

February 18, 2025