Company: SFNC
Filing Date: 2025-07-23
Form Type: 424B5
Source: 0001193125-25-162761
Chunk: 36

Company: SIMMONS FIRST NATIONAL CORP
Filing Date: 2025-07-23
Form: 424B5
Chunk 36
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 any shares of our common stock or any securities convertible into or exchangeable or exercisable for shares of our                                                                        
 common stock, whether the common stock is owned on the date of this prospectus supplement or acquired after the date of this prospectus supplement, or file (with respect to the Company) or cause to be filed any registration statement relating to any 
 of the restricted activities;                                                                                                                                                                                                                             |

| • |     | enter into any swap, hedge or any other agreement or any transaction that transfers, in whole or in part, the                                                                                                                                             
 economic consequences of ownership of our common stock or any securities convertible into or exchangeable or exercisable for our common stock, whether the swap, hedge or transaction is to be settled by delivery of shares of our common stock or other 
 securities, in cash or otherwise; or                                                                                                                                                                                                                      |

| • |     | publicly disclose the intention to make any such offer, pledge, sale or disposition, or to enter into any such 
 swap, hedge, transaction or other arrangement.                                                                 |

These restrictions are expressly agreed to in order to preclude us, and our executive officers and directors, from engaging in any hedging or other transaction or arrangement that is designed to, or which reasonably could be expected to, lead to or result in a sale, disposition or transfer, in whole or in part, of any of the economic consequences of ownership of our common stock, whether such transaction would be settled by delivery of our common stock or other securities, in cash or otherwise. These restrictions are subject to customary exceptions, including:

| • |     | transfers as bona fide gifts or by will or intestate succession, |

| • |     | transfers to immediate family members or trusts for estate planning purposes, |

| • |     | transfers by operation of law (such as pursuant to a domestic relations order), |

| • |     | transfers pursuant to the exercise of stock options that have been granted by the Company prior to, and are                                                                                                                                                                                                                                                             
 outstanding as of, the date of the underwriting agreement, where the shares of Common Stock received upon any such exercise are held by such executive officer or director, individually or as fiduciary, in accordance with the terms of the lock-up agreement (except to the extent sold solely to pay, and in an amount not to exceed, the exercise price therefor), |

S-30

| • |     | transfers to the Company solely to satisfy tax withholding obligations in connection with the exercise or vesting 
 of equity awards,                                                                                                 |

|