Company: CRNX
Filing Date: 2025-02-27
Form Type: S-8
Source: 0000950170-25-029087
Chunk: 0

Company: Crinetics Pharmaceuticals, Inc.
Filing Date: 2025-02-27
Form: S-8
Chunk 0
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<div align='center'>As filed with the Securities and Exchange Commission on February 27, 2025</div>

Registration No. 333-

<div align='center'>UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM S-8

REGISTRATION STATEMENT UNDER

THE SECURITIES ACT OF 1933

CRINETICS PHARMACEUTICALS, INC.

(Exact Name of Registrant as Specified in its Charter)</div>

| Delaware                          |     | 26-3744114                          |
| (State or Other Jurisdiction      |     | -I.R.S. Employer Identification No. |
| of Incorporation or Organization) |     |                                     |

<div align='center'>6055 Lusk Boulevard

San Diego, California 92121

(Address of principal executive offices) (Zip code)

Crinetics Pharmaceuticals, Inc. 2018 Incentive Award Plan

Crinetics Pharmaceuticals, Inc. 2018 Employee Stock Purchase Plan

Crinetics Pharmaceuticals, Inc. 2021 Employment Inducement Incentive Award Plan

(Full title of the plans)

R. Scott Struthers

President and Chief Executive Officer

Crinetics Pharmaceuticals, Inc.

6055 Lusk Boulevard

San Diego, California 92121

(885) 450-6464

(Name, address, and telephone number, including area code, of agent for service)

Copies to:</div>

| James Krenn, Esq.       
 Morrison & Foerster LLP 
 12531 High Bluff Drive  
 San Diego, CA 92130     
 (858) 720-5100          | G. Scott Lesmes, Esq.Emily K. Beers, Esq.Morrison & Foerster LLP2100 L Street NW, Suite 900Washington, D.C. 20037(202) 887-1500 |

<div align='center'>Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act. (Check one):</div>

| Large accelerated filer ý |     | Accelerated filer ¨         |