Company: PSTV
Filing Date: 2025-06-09
Form Type: DRS
Source: 0000950123-25-005986
Chunk: 52

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-06-09
Form: DRS
Chunk 52
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 Form of First Amendment to Securities Purchase and Exchange Agreement, dated as of March 4, 2025                                                                       |     | 8-K                       |     | 001-34375   |     |    10.3 |     | 03/04/2025  |
| 23.1*   |     | Consent of Independent Registered Public Accounting Firm.                                                                                                              |     |                           |     |             |     |         |     |             |
| 23.2*   |     | Consent of Sullivan & Worcester LLP (included in Exhibit 5.1 hereto).                                                                                                  |     |                           |     |             |     |         |     |             |
| 24.1    |     | Power of Attorney.                                                                                                                                                     |     |                           |     |             |     |         |     |             |
| 107*    |     | Filing Fee Table                                                                                                                                                       |     |                           |     |             |     |         |     |             |

| 

# | Indicates management contract or compensatory plan or arrangement. |
| + | Portions of this exhibit have been redacted pursuant to Item 601(b)(10)(iv). |

| * | To be filed by amendment. |

II-9

Confidential Treatment Requested by Plus Therapeutics, Inc. Pursuant to 17 C.F.R. Section 200.83 SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Houston, State of Texas, on [ ], 2025.

| PLUS THERAPEUTICS, INC. |     |                                       |
| By:                     |     |                                       |
|                         |     | Marc H. Hedrick, MD                   |
|                         |     | President and Chief Executive Officer |

POWER OF ATTORNEY KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints Marc H. Hedrick, MD and Andrew Sims, and each of them, his or her true and lawful attorneys-in-factand agents, with full power of substitution and re-substitution,for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Registration Statement, and any registration statement relating to the offering covered by this Registration Statement and filed pursuant to Rule