Company: SCLXW
Filing Date: 2025-12-17
Form Type: 424B3
Source: 0001193125-25-321974
Chunk: 2

Company: Scilex Holding Co
Filing Date: 2025-12-17
Form: 424B3
Chunk 2
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ITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 16, 2025 _______________________ SCILEX HOLDING COMPANY (Exact name of registrant as specified in its charter) _______________________

| Delaware                     
 (State or other jurisdiction 
 of incorporation)            | 001-39852    
 (Commission  
 File Number) | 92-1062542          
 (IRS Employer       
 Identification No.) |

960 San Antonio Road, Palo Alto, California, 94303 (Address of principal executive offices, including zip code) (650) 516-4310 Registrant’s telephone number, including area code N/A (Former Name or Former Address, if Changed Since Last Report) _______________________ Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

| ☐ |     | Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)                  |
| ☐ |     | Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)                 |
| ☐ |     | Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
| ☐ |     | Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |

Securities registered pursuant to Section 12(b) of the Exchange Act:

| (Title of each class)                                                                | -Trading Symbol | -Name of exchange on which registered |
| Common Stock, par value $0.0001 per share                                            | SCLX            | The Nasdaq Stock Market LLC           |
| Warrants to purchase one share of common stock, each at an exercise price of $402.50 | SCLXW           | The Nasdaq Stock Market LLC           |

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter). Emerging growth company ☒ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with