Company: TAK
Filing Date: 2025-06-26
Form Type: 424B5
Source: 0001395064-25-000101
Chunk: 66

Company: TAKEDA PHARMACEUTICAL CO LTD
Filing Date: 2025-06-26
Form: 424B5
Chunk 66
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 of all other sums payable under the applicable indenture by it; and

(3) the issuer (or, if applicable, the Guarantor) has delivered to the trustee an officer’s certificate and an opinion of counsel, each stating that all conditions precedent herein provided for relating to the satisfaction and discharge of the applicable indenture have been complied with.

#### Modification and Waiver
Modification and amendment of the senior debt securities of any series and the Indentures may be made by the issuer, the Guarantor (if applicable) and the trustee with the written consent of the holders of not less than a majority of the aggregate principal amount of the outstanding senior debt securities of each affected series; provided,

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however, that no such modification or amendment may, without the consent of the holder of each outstanding senior debt security affected thereby:

(i) change the maturity date of the principal or payment date of any interest or change any obligation of the issuer (or, if applicable, the Guarantor) to pay any additional amounts;

(ii) reduce the principal amount of, or rate of interest on, any senior debt securities;

(iii) change the redemption date or price at which senior debt securities are redeemed;

(iv) affect the rights of holders of less than all the outstanding senior debt securities;

(v) change the place of payment where, or the coin or currency in which, any note or interest thereon is payable; or

(vi) impair the right of a holder to institute suit for the enforcement of any payment on or with respect to any senior debt securities on or after the date when due;

provided, further, that no such modification may, without the consent of the holders of all senior debt securities of the affected series outstanding at the time, alter the respective percentages of outstanding senior debt securities necessary, pursuant to the applicable indenture, to modify the terms of the senior debt securities, waive past defaults or accelerate the payment of the principal amount of the senior debt securities.

It shall not be necessary for any act of holders under the relevant section of the applicable indenture to approve the particular form of any proposed supplemental indenture, but it shall be sufficient if such act shall approve the substance thereof.

Notwithstanding the foregoing, without the consent of any affected holders of the senior debt securities, the issuer, the Guarantor (if applicable) and the trustee, at any time and from time to time, may enter into one or more indentures supplemental to the applicable indenture, in form satisfactory to the trustee,