Company: ERAS
Filing Date: 2025-08-12
Form Type: S-3
Source: 0001193125-25-179038
Chunk: 53

Company: Erasca, Inc.
Filing Date: 2025-08-12
Form: S-3
Chunk 53
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 provide written confirmation to us before the open of the Nasdaq Global Select Market on the day following each day on which our shares of
common stock are sold under the Sale Agreement. Each confirmation will include the number of shares sold on that day, the aggregate gross proceeds of such sales and the proceeds to us.

In connection with the sale of the shares of common stock on our behalf, Jefferies will be deemed to be an “underwriter” within the meaning of the
Securities Act, and the compensation of Jefferies will be deemed to be underwriting commissions or discounts. We have agreed to indemnify Jefferies against certain civil liabilities, including liabilities under the Securities Act. We have also
agreed to contribute to payments Jefferies may be required to make in respect of such liabilities.

The offering of our shares of common stock will
terminate upon termination of the Sale Agreement as permitted therein.

This summary of the material provisions of the Sale Agreement does not purport to
be a complete statement of its terms and conditions. A copy of the Sale Agreement is filed as an exhibit to the registration statement of which this prospectus forms a part.

S-11

Jefferies and its affiliates have provided, and may in the future provide, various investment banking,
commercial, banking, financial advisory and other financial services for us and our affiliates for which services they may in the future receive customary fees. In the course of its business, Jefferies may actively trade our securities for its own
account or for the accounts of customers, and, accordingly, Jefferies may at any time hold long or short positions in such securities.

This prospectus
and the accompanying base prospectus in electronic format may be made available on a website maintained by Jefferies, and Jefferies may distribute this prospectus and accompanying base prospectus electronically.

S-12

LEGAL MATTERS

Latham & Watkins LLP, San Diego, California, will pass upon certain legal matters relating to the issuance and sale of the securities offered hereby
on behalf of Erasca, Inc. Latham & Watkins LLP and certain attorneys in the firm who have rendered, and will continue to render, legal services to us, own shares of our common stock representing in the aggregate less than one percent of the
shares of our common stock outstanding. Jefferies LLC is being represented in connection with this offering by Cooley LLP, New York, New York.

EXPERTS

The
consolidated financial statements of Erasca, Inc. as of December