Company: LENZ
Filing Date: 2025-04-14
Form Type: 424B5
Source: 0001628280-25-017695
Chunk: 54

Company: LENZ Therapeutics, Inc.
Filing Date: 2025-04-14
Form: 424B5
Chunk 54
---
 Report on Form 10-K for the year ended December 31, 2024, filed with the SEC on March 19, 2025 ; and

• our Item 1.01 and 9.01 Current Report on Form 8-K filed with the SEC on April 4, 2025 ; and

• the description of our Common Stock contained in the Annual Report on Form 10-K filed on March 19, 2025 .

You may request a copy of these filings, at no cost, by writing or telephoning us at the following address and telephone number:

<div align='center'>LENZ Therapeutics, Inc.

201 Lomas Santa Fe Dr., Suite 300

Solana Beach, California 92075

Attn: Investor Relations

(858) 925-7000

26</div>

#### Up to $150,000,000

#### Common Stock

### PROSPECTUS SUPPLEMENT
| TD Cowen |

#### April 14, 2025