Company: PSTV
Filing Date: 2025-04-04
Form Type: S-3
Source: 0001193125-25-073481
Chunk: 2

Company: PLUS THERAPEUTICS, INC.
Filing Date: 2025-04-04
Form: S-3
Chunk 2
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 or “our”), which may be offered for sale from time to time by selling stockholders named herein. The shares of common stock covered in this prospectus consist of:

| • |     | up to 3,077,270 shares of common stock; |

| • |     | up to 19,650,000 shares of common stock issuable upon exercise of 
 pre-funded warrants (“Pre-Funded Warrants”);                      |

| • |     | up to 280,421,380 shares of common stock that as a result of certain adjustment provisions set forth in the Series                                                                           
 A common stock warrants (“Series A Common Stock Warrants”) and assumptions described elsewhere in this prospectus could become issuable upon exercise of Series A Common Stock Warrants; and |

| • |     | up to 1,261,896,210 shares of common stock that as a result of certain adjustment provisions set forth in the                                                                                                                    
 Series B common stock warrants (“Series B Common Stock Warrants”, and together with the Series A Common Stock Warrants, the “Common Warrants”) and assumptions described elsewhere in this prospectus could become issuable upon 
 exercise of Series B Common Stock Warrants.                                                                                                                                                                                      |

The shares of common stock, Pre-FundedWarrants and Common Warrants were issued pursuant to the Securities Purchase Agreement, dated March 4, 2025 (the “Purchase Agreement”), among us and certain accredited investors (the “Purchasers,” or “selling stockholders”). The shares of common stock are registrable for resale pursuant to the Registration Rights Agreement, dated March 4, 2025 (the “Registration Rights Agreement”), that we entered into with the Purchasers in connection with the Purchase Agreement. See the section entitled “Selling Stockholders” for additional information regarding the Purchasers. Our registration of the resale of the shares of common stock covered by this prospectus does not mean that the selling stockholders will offer or sell all or any of the shares of common stock. The selling stockholders may offer, sell or distribute all or portion of their shares of common stock from time to time directly or indirectly through one or more underwriters, broker-dealers or agents, and in one or more public or private transactions. The shares of common stock may be sold in one or more transactions at fixed prices, at prevailing market prices at the time of the sale, at varying prices determined at the time of sale or at negotiated prices. These sales may be effected in transactions, which may involve crosses or block