Company: CMND
Filing Date: 2025-01-22
Form Type: 20-F
Source: 0001213900-25-005490
Chunk: 115

Company: Clearmind Medicine Inc.
Filing Date: 2025-01-22
Form: 20-F
Item: Item 4
Chunk 115
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is not limited to these substances. Compulsive consumption of food, shopping, gambling, sex, television, and technology, many of which
increased in prevalence during the recent pandemic, can all be destructive when their use cannot be managed and all can potentially be
treated by MEAI.

Alcohol Use Disorder

The Diagnostic and Statistical Manual of Mental
Disorders, 5th Edition (DSM-5) criteria of AUD are as follows:

  A maladaptive pattern of substance use leading to clinically significant impairment or distress, as manifested by 2 or more of the following, occurring at any time in the same 12-month period:  
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  Alcohol is often taken in larger amounts or over a longer period than was intended.  
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  There is a persistent desire or unsuccessful efforts to cut down or control alcohol use.  

  A great deal of time is spent in activities necessary to obtain alcohol, use alcohol, or recover from its effects.  

  Craving, or a strong desire or urge to use alcohol.  

  Recurrent alcohol use resulting in a failure to fulfill major role obligations at work, school, or home.  

  Continued alcohol use despite having persistent or recurrent social or interpersonal problems caused or exacerbated by the effects of alcohol.  

  Important social, occupational, or recreational activities are given up or reduced because of alcohol use.  

  Recurrent alcohol use in situations in which it is physically hazardous.  

  Alcohol use is continued despite knowledge of having a persistent or recurrent physical or psychological problem that is likely to have been caused or exacerbated by alcohol.  

  Tolerance, as defined by either of the following:  

  o       A need for markedly increased amounts of alcohol to achieve intoxication or desired effect.  
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  o       A markedly diminished effect with continued use of the same amount of alcohol.  

Excessive alcohol use is costly, as described by
the graphic below:

“ Excessive Drinking is Draining the U. S.
Economy:”

According to the CDC, the cost of excessive alcohol
uses in the United States reached $249 billion in 2010, which equates to about $2.05 per drink consumed, and $807 per person.

There are limited pharmacological agents