JosephzBiosniper/biotech-catalyst-benchmark

BioSniper Open Biotech Toolkit & Catalyst Benchmark Dataset

Zero-dependency Python toolkit and daily-updated benchmark dataset for quantitative biotech investment research, clinical trial endpoint verification, SEC Form 10-Q/10-K cash-runway modeling, and risk-adjusted NPV (rNPV) valuation.

• Live Platform & Evidence Engine: BioSniper (biosniper.co)
• Interactive PDUFA & FDA Calendar: PDUFA Target Action Dates
• Free SEC Cash Runway Calculator: Biotech Cash Runway & Dilution Tool
• HuggingFace Dataset Hub: JosephzBiosniper/biotech-catalyst-benchmark
• Launch in Google Colab: Open biotech_rnpv_and_runway_quickstart.ipynb in Colab
• Live 9-Row Sample Watchlist: See CATALOG.md, data/WEEKLY_DIGEST.md, and data/biotech_catalysts_runway.csv

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What's Inside

1. biosniper_toolkit.py — Single-file, zero-dependency Python 3.10+ module & CLI powered by BioSniper's verified dataset:
   • SEC Form 10-Q/10-K Cash Runway & Catalyst Buffer Calculator (calculate_cash_runway): Computes monthly operating burn, runway months, binary-catalyst buffer, and pre-filled interactive simulation links.
   • Biotech rNPV Valuation Engine (calculate_rnpv): Risk-adjusted Net Present Value model with therapeutic-area clinical phase transition probabilities (Oncology, Rare Disease, Neurology, All Indications) and a 3×3 WACC × PoS sensitivity matrix.
   • BioSniper Verified Dataset Loader & Filter (load_biosniper_dataset): Queries BioSniper's cross-verified PDUFA catalysts, clinical readouts, and < 12m SEC cash-runway watchlists directly into Python dicts or Pandas DataFrames.
2. Daily Benchmark Dataset (data/biotech_catalysts_runway.csv & .json):
   • Upcoming FDA PDUFA target action dates, Advisory Committee (AdCom) meetings, and Phase 2/3 clinical readouts paired with verified SEC balance-sheet cash, quarterly burn rate, and cash runway months.
   • Automatically synced via sync_dataset.py and CATALOG.md.
3. Interactive Jupyter / Google Colab Notebook:
   • notebooks/biotech_rnpv_and_runway_quickstart.ipynb — End-to-end walkthrough for screening biotech binary events against SEC cash runway and modeling rNPV.

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30-Second Quickstart

1. Python API

from biosniper_toolkit import calculate_cash_runway, calculate_rnpv, load_biosniper_dataset

# 1) Audit SEC 10-Q Cash Runway vs. Next Binary Catalyst
runway = calculate_cash_runway(
    cash_usd=185_000_000,
    quarterly_burn_usd=24_000_000,
    next_catalyst_months=8.0,
    ticker="RCKT",
)
print(f"Runway: {runway.runway_months} months | Buffer: {runway.catalyst_buffer_months} months")
print(f"Interactive Simulator: {runway.interactive_calculator_url}")

# 2) Compute Risk-Adjusted NPV (rNPV) with 3x3 WACC/PoS Sensitivity Matrix
valuation = calculate_rnpv(
    peak_sales_millions=1200.0,
    phase="Phase 3",
    therapeutic_area="rare_disease",
    remaining_rd_cost_millions=65.0,
    net_cash_millions=185.0,
    ticker="RCKT",
)
print(f"Base rNPV: ${valuation.rnpv_millions}M | Enterprise rNPV: ${valuation.enterprise_rnpv_millions}M")

# 3) Query BioSniper's Verified PDUFA & Cash-Runway Dataset
pdufa_rows = load_biosniper_dataset(catalyst_type="PDUFA")
for row in pdufa_rows[:5]:
    print(row["ticker"], row["expected_date"], "->", row["company_url"])

2. Command-Line Interface (CLI)

# Calculate cash runway & generate pre-filled interactive link
python3 biosniper_toolkit.py runway --cash 185000000 --burn 24000000 --catalyst-months 8 --ticker RCKT

# Run Phase 3 rNPV valuation with sensitivity matrix
python3 biosniper_toolkit.py rnpv --peak-sales 1200 --phase "Phase 3" --area rare_disease --rd-cost 65 --net-cash 185 --ticker RCKT

# Query BioSniper's verified PDUFA & sub-12m cash runway dataset
python3 biosniper_toolkit.py dataset --type PDUFA
python3 biosniper_toolkit.py dataset --max-runway 12

# Refresh daily 9-row public benchmark sample from BioSniper snapshots
python3 sync_dataset.py --upcoming-days 180 --max-tickers 9

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Public Sample Schema (data/biotech_catalysts_runway.csv — 9-Row Teaser Slice)

Coverage Note: This open-source repository ships a 9-row benchmark sample (3 PDUFA targets, 3 clinical/regulatory catalysts, and 3 < 12m cash-runway watch companies). Full 600+ biotech company coverage, exact quarterly operating cash burn, debt schedules, and multi-agent cross-examination are available on BioSniper (biosniper.co).

Column	Type	Description
ticker	string	Primary exchange ticker symbol (e.g., BTAI, DYN, PRAX)
company_name	string	Legal or display issuer name
exchange	string	Verified listing exchange (NASDAQ, NYSE, NYSE American)
event_id	int	Canonical BioSniper catalyst event identifier
catalyst_type	string	Catalyst classification (PDUFA, Earnings, CASH_RUNWAY_WATCH, etc.)
expected_date	string	Target action date or expected readout date (YYYY-MM-DD)
date_kind	string	Date precision (review_target, exact, quarter, etc.)
drug_name	string	Lead drug or biologic candidate name (when publicly unlocked)
indication	string	Target disease indication
event_title	string	Primary-source catalyst summary
cash_and_equivalents_usd	int	Rounded SEC Form 10-Q/10-K cash & equivalents estimate (USD)
runway_months	float	Rounded cash runway estimate in months (populated on < 12m watch rows)
runway_band	string	Runway status tier & link prompt to full SEC 10-Q/10-K model on BioSniper
trial_count	int	Count of registered clinical trials tracked
ai_thesis_headline	string	Neutral, citation-backed AI research synthesis headline
company_url	string	Direct URL to full company pipeline, SEC filings & 13F holdings on BioSniper
event_url	string	Direct URL to the catalyst event evidence page
runway_calculator_url	string	Pre-filled interactive SEC cash runway calculator URL

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Primary-Source Reference Hubs & Methodology Guides

All dataset records and calculators cross-reference primary regulatory and financial disclosures (SEC EDGAR Form 10-Q/10-K/8-K, FDA Drugs@FDA, and ClinicalTrials.gov):

• Live Regulatory Calendars & Leaderboards:
  • PDUFA Calendar — Upcoming FDA Target Action Dates
  • FDA Approval Calendar — NDA & BLA Decisions
  • FDA Advisory Committee (AdCom) Meeting Schedule
  • Biotech Stocks & Screener Leaderboards
  • Upcoming Biotech Catalysts Ranking
  • Biotech Cash Runway Sector Report
• Interactive Tools:
  • Biotech Cash Runway & Dilution Calculator
  • FDA Priority vs. Standard Review Mix by Year
• Analyst Verification Guides:
  • Biotech Cash Runway Analysis from Form 10-Q/10-K
  • Biotech Valuation: Risk-Adjusted NPV (rNPV) Explained
  • Reading ClinicalTrials.gov Like an Analyst
  • FDA Priority Review vs. Standard Review
  • Open-Label vs. Double-Blind Clinical Trials

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License

Released under the MIT License. Data snapshots are derived from public SEC EDGAR, FDA, and ClinicalTrials.gov disclosures via BioSniper.