RAL Datasets
Collection
Datasets for Reinforced Adversarial Learning: training reasoning models from reference answers alone. • 5 items • Updated
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values | doi stringlengths 31 55 | source_url stringlengths 31 55 | openalex_id stringlengths 32 32 | publication_date stringdate 2000-01-01 00:00:00 2026-04-29 00:00:00 |
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Making Chatbots more human: deep reasoning large language models in ophthalmology | Recent advances in deep-reasoning large language models (LLMs)—including OpenAI’s GPT series and open-source DeepSeek models—have expanded their potential applications in ophthalmology. In ophthalmology, image interpretation continues to rely primarily on conventional computer vision and vision language model pipelines... | [
"Xuanqiao Lin",
"Yizhou Yang",
"Yuecheng Ren"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Frontiers in Medicine | 2296-858X | Frontiers Media | gold | https://doi.org/10.3389/fmed.2025.1741888 | https://doi.org/10.3389/fmed.2025.1741888 | https://openalex.org/W7122538226 | 2026-01-12 |
Improvement of Lower Facial Shape after Treatment with OnabotulinumtoxinA: Secondary Results from a Phase 2 Dose Escalation Study | Masseter muscle prominence (MMP) contributes to a widened lower facial shape, considered aesthetically undesirable to some individuals. This study assessed lower facial shaping improvements with onabotulinumtoxinA. In a phase 2, randomized, placebo-controlled study, onabotulinumtoxinA (24, 48, 72, or 96 U) or placebo w... | [
"Steven Liew",
"Jason Keller Rivers",
"Shannon D. Humphrey",
"JEAN D. A. CARRUTHERS",
"Shyi-Gen Chen",
"Beta Bowen",
"Elisabeth Lee",
"Mitchell F. Brin"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Plastic & Reconstructive Surgery | 0032-1052 | Lippincott Williams & Wilkins | hybrid | https://doi.org/10.1097/prs.0000000000012345 | https://doi.org/10.1097/prs.0000000000012345 | https://openalex.org/W4413112216 | 2025-08-13 |
Machine learning assessment of retinal blood flow links metabolic dysfunction and accelerated microvascular aging | Microvascular aging impairs tissue perfusion and contributes to age-related organ dysfunction; however, direct approaches to assess microvascular aging remain limited. Here, we developed machine learning models to estimate chronological age from retinal blood flow data acquired by laser speckle flowgraphy (LSFG) in 1,0... | [
"Shigeyuki Magi",
"Takahiro Maruyama",
"Seiji T. Takagi",
"Atsuhiko T. Naito",
"Yuichi Hori"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Scientific Reports | 2045-2322 | Nature Portfolio | gold | https://doi.org/10.1038/s41598-025-32776-3 | https://doi.org/10.1038/s41598-025-32776-3 | https://openalex.org/W7118557888 | 2026-01-07 |
TLR7 inhibition limits cardiac ischemic injury by disrupting ITGAM-dependent immune–endothelial interaction | Percutaneous coronary intervention (PCI) limits ischemic myocardial infarction but also triggers ischemia-reperfusion (I/R) injury in part driven by innate immune activation. Here, we identify Tolllike receptor 7 (TLR7), an endosomal sensor of single-stranded RNA, as a mediator of postischemic inflammation and myocardi... | [
"Yijia Li",
"Yang Yang",
"Chanhee Park",
"Boyang Ren",
"Ruoxing Li",
"Amol Shetty",
"Brittney Williams",
"Ziyi Li",
"Lin Zou",
"Wei Chao"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | JACC Basic to Translational Science | 2452-302X | Elsevier BV | gold | https://doi.org/10.1016/j.jacbts.2026.101626 | https://doi.org/10.1016/j.jacbts.2026.101626 | https://openalex.org/W7168249168 | 2026-01-21 |
OPPORTUNITIES FOR AI IN DISEASE SURVEILLANCE | Infectious disease surveillance in LMICs faces persistent gaps in data timeliness, quality, and coverage. Artificial Intelligence (AI) tools including machine learning (ML) and generative AI (Gen AI) offer new opportunities to strengthen early detection, analysis, and decision-making across the entire surveillance life... | [
"Courage O Idahor",
"Ena-Jane O Esomu",
"Ndidiamaka Ogbonna",
"Zaafirah Momoh",
"Omo A Ogbeide",
"Osamagbe Ikhu-Omoregbe",
"Augustina Adigwe",
"Osayuwamen M Erhabor",
"Osamagbe Osaghae",
"Nosa Orons"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cureus | 2168-8184 | Cureus, Inc. | diamond | https://doi.org/10.7759/cureus.93929 | https://doi.org/10.7759/cureus.93929 | https://openalex.org/W4414861152 | 2025-10-06 |
Key Challenges in Screening Blood Donors for Hepatitis B Virus | Technological advancements in blood donor screening have significantly improved blood safety. However, certain testing challenges and limitations continue to face blood banks in donor screening for the hepatitis B virus, resulting in occasional cases of transfusion transmission. These cases are mostly related to donors... | [
"Maha A. Badawi",
"Maha A. Badawi",
"Sahar Eldakhakhny",
"Mohamed Ali",
"Mazen Abdulrazak Badawi",
"Mazen Abdulrazak Badawi",
"Jaffar Khiariy",
"Yagoub Y. Bin-Taleb",
"Salwa Hindawi"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Viruses | 1999-4915 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/v18010023 | https://doi.org/10.3390/v18010023 | https://openalex.org/W7116827273 | 2025-12-23 |
Comparative infection risk in CAR T vs bispecific antibodies in B-cell lymphoma: a systematic review and meta-analysis | CD3xCD20 bispecific antibody (BsAb) therapy and CD19-directed chimeric antigen receptor T-cell therapy (CAR T) are novel immunotherapies that have shown impressive efficacy in B-cell lymphomas, but also come with significant morbidity and mortality, including infections. This meta-analysis compares rates of infections ... | [
"Herman J. van Besien",
"Neela Easwar",
"Michelle R. Demetres",
"Michelle Pasciolla",
"Tsiporah B. Shore",
"John Paul Leonard",
"Juliet N. Barker",
"Peter Martin",
"Samuel Yamshon"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Blood Advances | 2473-9529 | Elsevier BV | gold | https://doi.org/10.1182/bloodadvances.2025016291 | https://doi.org/10.1182/bloodadvances.2025016291 | https://openalex.org/W4411874373 | 2025-07-01 |
Segmental body BIA device development for fracture detection | Bone fractures are a major health issue worldwide, often requiring diagnostic tools like X-rays or CT scans, which, despite their effectiveness, present drawbacks such as radiation exposure, high cost, and limited accessibility. To address these limitations, this study introduces a novel, low-cost, portable, and non-in... | [
"Km. Brajesh",
"Mahmood Aldobali",
"Kirti Pal",
"Munna Khan"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Scientific Reports | 2045-2322 | Nature Portfolio | gold | https://doi.org/10.1038/s41598-025-28403-w | https://doi.org/10.1038/s41598-025-28403-w | https://openalex.org/W4417213283 | 2025-12-11 |
Designing a regional clinical service for people with early-onset type 2 diabetes in England | Aims: To design a regional clinical service for people with early-onset type 2 diabetes (EOT2D) in Leicester, Leicestershire and Rutland (England). Methods: A literature search was undertaken to identify important considerations. A working group of key stakeholders was formed to design a triage system and service pathw... | [
"Jonathan Goldney",
"Victoria Alabraba",
"Priscilla Sarkar",
"Harriet Morgan",
"Malak Hamza",
"Michael Skarlatos",
"Tommy Slater",
"Jack Alistair Sargeant",
"Rhys O'Callaghan",
"Michelle Hadjiconstantinou",
"Julia Burdon",
"Azhar Farooqi",
"Samuel Iddrisu Seidu",
"Claire L. Meek",
"Mela... | cc-by | https://creativecommons.org/licenses/by/4.0/ | Diabetic Medicine | 0742-3071 | Wiley | hybrid | https://doi.org/10.1111/dme.15479 | https://doi.org/10.1111/dme.15479 | https://openalex.org/W4404729843 | 2024-11-25 |
Potential Therapeutic Targets and Emerging Strategies to Promote Hematoma Resolution in Intracerebral Hemorrhage | Intracerebral hemorrhage (ICH) is a devastating stroke subtype with high morbidity and mortality. Beyond primary injury from blood extravasation, secondary injury driven by erythrocyte lysis and its toxic degradation products exacerbates inflammation, oxidative stress, and neuronal damage. Accelerating endogenous hemat... | [
"Shuling Wan",
"Xunming Ji",
"Ran Meng",
"Min null Li"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Revista de Neurología | 0210-0010 | Viguera Publishers | hybrid | https://doi.org/10.31083/rn46121 | https://doi.org/10.31083/rn46121 | https://openalex.org/W7117716486 | 2025-12-22 |
Endoscopic and Hybrid Approaches for Gastric Subepithelial Tumors: Expanding the Frontiers of Minimally Invasive Therapy | Per-oral flexible endoscopy has expanded minimally invasive options for the management of gastric subepithelial tumors (G-SETs). This narrative review appraises conventional and advanced endoscopic resections alongside hybrid laparoscopic–endoscopic procedures, within a size- and layer-based clinical framework. Endosco... | [
"Francesco Bombaci",
"Angelo Bruni",
"Michele Dota",
"Massimo Del Gaudio",
"Giuseppe Dell’Anna",
"Francesco Vito Mandarino",
"Francesco Azzolini",
"E. Sinagra",
"Lorenzo Fuccio",
"Rocco Maurizio Zagari",
"Giovanni Barbara",
"Paolo Cecinato"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Gastroenterology Insights | 2036-7414 | PAGEPress (Italy) | gold | https://doi.org/10.3390/gastroent17010013 | https://doi.org/10.3390/gastroent17010013 | https://openalex.org/W7128504800 | 2026-02-10 |
A viral glycoprotein targets IgG[+] memory B cells to mediate humoral immune evasion | Virus infections elicit long-term IgG antibody and memory responses. Human cytomegalovirus (HCMV) is widespread in humans and disseminates despite the presence of virus-specific antibodies. Here, we report that the HCMV Fcγ-binding glycoprotein 34 modulates humoral immunity by binding to IgG⁺ memory B cells. gp34–B cel... | [
"Precious Cramer",
"Stefan F. H. Neys",
"Manuela Fiedler",
"Raquel Lorenzetti",
"Henrike Reinhard",
"Iga Janowska",
"Julian Staniek",
"Ann-Katrin Kohl",
"Petra Hadlová",
"Magdalena Huber",
"Bodo Plachter",
"Clarissa Read",
"Valeria Falcone",
"Jens von Einem",
"Katja Hoffmann",
"Tihana ... | cc-by | https://creativecommons.org/licenses/by/4.0/ | EMBO Molecular Medicine | 1757-4676 | Springer Nature | gold | https://doi.org/10.1038/s44321-026-00372-1 | https://doi.org/10.1038/s44321-026-00372-1 | https://openalex.org/W7124851713 | 2026-01-20 |
Historic Real-World Outcomes and Future Benchmarks for Patients with Diffuse Large B-Cell Lymphoma Receiving First- and Second-Line in Austria – a Therapy Large Single-Center Experience | Background: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin-lymphoma. Although it can be cured in many patients, a significant proportion of patients fail the primary treatment and require second-line treatment. Currently, only limited data on real-world outcomes with standard therapies in ... | [
"Michael Leisch",
"Dominik Kiem",
"Christoph Grabmer",
"Anton Kugler",
"Gianfranco Pocobelli",
"Mayer Marie-Christina",
"Bernd Schöpf",
"Alexander Egle",
"Richard Greil",
"Thomas Melchardt"
] | cc-by-nc | https://creativecommons.org/licenses/by-nc/4.0/ | Technology in Cancer Research & Treatment | 1533-0338 | SAGE Publishing | gold | https://doi.org/10.1177/15330338251410356 | https://doi.org/10.1177/15330338251410356 | https://openalex.org/W7119521091 | 2026-01-01 |
Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer | Cachexia is a wasting disorder associated with high morbidity and mortality in patients with cancer. Tumour–host interaction and maladaptive metabolic reprogramming are substantial, yet poorly understood, contributors to cachexia. Here we present a comprehensive overview of the spatio-temporal metabolic reprogramming d... | [
"Pauline Morigny",
"Michaela Vondráčková",
"Honglei Ji",
"Kristýna Brejchová",
"Monika Krakovkova",
"Konstantinos Makris",
"Radka Trubacova",
"Tuna Felix Samanci",
"Doris Kaltenecker",
"Su-Ping Ng",
"Vignesh Karthikaisamy",
"Sophia E. Chrysostomou",
"Anna Bidovec",
"Mariana Ponce-de-Leon",... | cc-by | https://creativecommons.org/licenses/by/4.0/ | Nature Metabolism | 2522-5812 | Nature Portfolio | hybrid | https://doi.org/10.1038/s42255-025-01434-3 | https://doi.org/10.1038/s42255-025-01434-3 | https://openalex.org/W7124262000 | 2026-01-15 |
Multicompartment hydrogel microcapsules for creating spatially patterned cell co-cultures | There is increasing clinical evidence that pancreatic dysfunction in diabetes needs to be viewed in the context of crosstalk with the liver as well as other organs. Our goal for this study was to develop a pancreas-liver co-culture system suited for mechanistic and therapy testing studies in the context of multi-organ ... | [
"Sungwoo Cho",
"Quoc Huynh Nguyen",
"José M. de Hoyos‐Vega",
"Ananya Bharath",
"Alan M. Gonzalez‐Suarez",
"Kianna M. Nguyen",
"Quang Tuan Che",
"Kihak Gwon",
"Aleksey V. Matveyenko",
"Gulnaz Stybayeva",
"Alexander Revzin"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Microsystems & Nanoengineering | 2055-7434 | Springer Nature | gold | https://doi.org/10.1038/s41378-025-01140-w | https://doi.org/10.1038/s41378-025-01140-w | https://openalex.org/W7119525083 | 2026-01-09 |
Proteomic Study of Diffuse Large B-Cell Lymphoma Identifying Proteins Associated with R-CHOP Response | Diffuse large B-cell lymphoma (DLBCL) is a molecularly and pathogenically heterogenous disease with varying clinical outcomes, as reflected by the significant number of patients who develop relapse/refractory disease (rrDLBCL) following standard treatment with the combined R-CHOP regimen. The molecular background of rr... | [
"Hulda Haraldsdóttir",
"Rasmus Froberg Brøndum",
"Marie Beck Enemark",
"Bent Honoré",
"Maja Ludvigsen",
"Christopher Aboo",
"Allan Stensballe",
"Judit Meszaros Jørgensen",
"Hanne Due",
"Karen Dybkær"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Biomedicines | 2227-9059 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/biomedicines13112709 | https://doi.org/10.3390/biomedicines13112709 | https://openalex.org/W4415908963 | 2025-11-04 |
The Long‑Term Cost‑Effectiveness of Tirzepatide 5 mg versus Dulaglutide 0.75 mg for the Treatment of People with Type 2 Diabetes in Japan | This analysis aimed to evaluate the long-term cost-effectiveness of tirzepatide 5 mg versus dulaglutide 0.75 mg (both administered once weekly) in people not achieving glycemic control on metformin, based on the results of the head-to-head SURPASS J-mono trial from a Japanese healthcare payer perspective. A cost-utilit... | [
"Toshihiko Aranishi",
"Ataru Igarashi",
"Kazuo Hara",
"Beatrice Osumili",
"Zhihong Cai",
"Aska Mizogaki",
"Manaka Sato",
"Masakazu Takeuchi",
"Alice Minghetti",
"Barnaby Hunt",
"Takashi Kadowaki"
] | cc-by-nc | https://creativecommons.org/licenses/by-nc/4.0/ | Diabetes Therapy | 1869-6953 | Adis, Springer Healthcare | gold | https://doi.org/10.1007/s13300-024-01675-7 | https://doi.org/10.1007/s13300-024-01675-7 | https://openalex.org/W4405673223 | 2024-12-21 |
Biology and evolving management of resectable dMMR/MSI‑H cancers: current status and future perspectives | Mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) tumors represent a biologically and immunologically distinct subset of solid malignancies. Defective DNA mismatch repair mechanisms in these tumors lead to the accumulation of insertion-deletion mutations, a hypermutated phenotype, and abundant... | [
"Tokiyoshi Tanegashima",
"Masaki Shiota",
"Kayo Toyosaki",
"Kouta Funakoshi",
"Masatoshi Eto"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cancer Immunology Immunotherapy | 0340-7004 | Springer Science+Business Media | gold | https://doi.org/10.1007/s00262-025-04223-9 | https://doi.org/10.1007/s00262-025-04223-9 | https://openalex.org/W4415958882 | 2025-11-06 |
Gene Expression Profiling Provides an Improved Characterization of CD79B-Mutated Diffuse Large B-Cell Lymphomas | Diffuse large B-cell lymphomas (DLBCLs) are heterogeneous neoplasms. CD79B and MYD88 mutations are associated with the activated B-cell-like (ABC) subtype of DLBCL and often co-occur and lead to constitutive activation of the NF-κB pathway. Several different genetic classifications to date have recognized CD79B- and MY... | [
"Luis Grossmann",
"Wolfgang Jagla",
"Marcus Bettstetter",
"Simone Bertz",
"Stephan Schwarz‐Furlan",
"Thomas Richter",
"Tobias Nicolaas Dechow",
"Thomas W. Decker",
"Martin H. Dreyling",
"Karl Sotlar",
"Harald S. Bartsch",
"Arndt Hartmann",
"Julius Honecker",
"Andreas K.A. Gaumann"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Journal of Personalized Medicine | 2075-4426 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/jpm15110548 | https://doi.org/10.3390/jpm15110548 | https://openalex.org/W4416074221 | 2025-11-10 |
Machine learning based on systemic inflammation response index and risk of cardiovascular disease in gout: a retrospective study and clinical validation | Gout is a chronic inflammatory disease, and cardiovascular disease (CVD) is regarded as one of its complications. The aim of our study was to explore the association between systemic inflammation response index (SIRI) and the risk of CVD in gout. Six cycles of NHANES data were analyzed. Machine learning algorithms were... | [
"Qiang Zhang",
"Xuan-hua Yu",
"Weizhen Zhang",
"Xue-bing Lyu",
"Hu-han Lin",
"Shan-ting Zeng",
"Changquan Liu",
"Huijuan Huang",
"Wei-zhe Deng"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Clinical Rheumatology | 0770-3198 | Springer Science+Business Media | hybrid | https://doi.org/10.1007/s10067-025-07750-z | https://doi.org/10.1007/s10067-025-07750-z | https://openalex.org/W4416345681 | 2025-11-18 |
Long Term Follow Up of Neoadjuvant Enzalutamide Plus Androgen Deprivation Therapy in Localized Prostate Cancer: A Secondary Analysis of a Neoadjuvant Feasibility Trial | Introduction: Neoadjuvant intense androgen deprivation therapy (ADT) with androgen receptor signaling inhibitors (ARSIs) has shown pathologic complete responses (pCR) in prostate cancer (PCa), but long‐term survival outcomes remain unclear. This study evaluates the durability of response following neoadjuvant ADT plus ... | [
"Braden Millan",
"Nikhil Pramod",
"Rubén Blachman-Braun",
"Jaskirat Saini",
"Lauren Loebach",
"Milan H. Patel",
"Sandeep Gurram",
"Barış Türkbey",
"Fatima H. Karzai",
"Peter A. Pinto"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | The Prostate | 0270-4137 | Wiley | hybrid | https://doi.org/10.1002/pros.70093 | https://doi.org/10.1002/pros.70093 | https://openalex.org/W4416263133 | 2025-11-16 |
Mechanism of the traditional Chinese medicine SMBJ alleviates diabetes mellitus-induced Leydig cell dysfunction in rats testes | Simiao Biejia Decoction (SMBJ), a traditional Chinese herbal formula, has been clinically applied to treat diabetes mellitus (DM)-induced male dysfunction due to its kidney-tonifying, heat-clearing, and blood-enriching properties. However, the precise molecular mechanisms and therapeutic targets through which SMBJ conf... | [
"Wenxiu Zhang",
"Yuanyuan Liu",
"Li Tong",
"Yihan Jin",
"Chao Gao",
"Yugui Cui",
"Baofang Jin",
"Dalin Sun"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Scientific Reports | 2045-2322 | Nature Portfolio | gold | https://doi.org/10.1038/s41598-025-23251-0 | https://doi.org/10.1038/s41598-025-23251-0 | https://openalex.org/W4416149740 | 2025-11-12 |
Design and rationale of the eLym[™] System for Decompensation of Excess Lymphatic Fluid via the Thoracic Duct in Acute Heart Failure (DELTA-HF) | The interstitial space is the major compartment in which the excess fluid is located, forming peripheral congestion in acute decompensated heart failure (ADHF). The lymphatic system is responsible for the constant drainage of the compartment. In ADHF, the inefficiency of this system causes extravascular fluid accumulat... | [
"Jan Biegus",
"JoAnn Lindenfeld",
"Gary Michael Felker",
"George L. Bakris",
"Michael Jonas",
"Anuradha Lala",
"Zviad Kereselidze",
"George Khabeishvili",
"Irakli Gogorishvili",
"Julio E. Núñez",
"Antoni Bayés‐Genís",
"Piotr P. Ponikowski",
"William T. Abraham"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | ESC Heart Failure | 2055-5822 | Wiley | gold | https://doi.org/10.1002/ehf2.15192 | https://doi.org/10.1002/ehf2.15192 | https://openalex.org/W4405761841 | 2024-12-24 |
Interplay Between Glutamine Metabolism and Other Cellular Pathways: A Promising Hub in the Treatment of HNSCC | Head and neck squamous cell carcinoma (HNSCC) is the most common and aggressive histologic subtype of head and neck cancer (HNC), difficult to treat effectively. Here, we discuss several studies on human and mouse HNSCC cell lines arising from the mucosal epithelium of various anatomical sites, as well as recent studie... | [
"Teresa Stefania Dell’Endice",
"Francesca Posa",
"Giuseppina Storlino",
"Lorenzo Sanesi",
"Lucio Lo Russo",
"Giorgio Mori"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cells | 2073-4409 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/cells14241962 | https://doi.org/10.3390/cells14241962 | https://openalex.org/W7113896064 | 2025-12-10 |
Targeting Cardiac Fibroblast Plasticity for Antifibrotic and Regenerative Therapy in Heart Failure | Cardiac fibrosis is a major component of heart failure (HF) and develops when reparative wound healing becomes chronic, leading to excessive extracellular matrix accumulation. Cardiac fibroblasts (CFs), the main regulators of matrix remodeling, are heterogeneous in developmental origins, regional localizations, and act... | [
"Suchandrima Dutta",
"Sophie Chen",
"Waqas Ahmad",
"Wei Chieh Huang",
"Jialiang Liang",
"Yigang Wang"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cells | 2073-4409 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/cells15020112 | https://doi.org/10.3390/cells15020112 | https://openalex.org/W7119526780 | 2026-01-08 |
Integrating binary classification and clustering for multi-class dysarthria severity level classification: a two-stage approach | Dysarthria, a motor speech disorder, poses challenges in accurate severity assessment. Recent research has excelled in classifying dysarthria based on severity levels, primarily utilizing annotated datasets and achieving high accuracies. However, these classification-based approaches may not readily translate to real-w... | [
"Afnan Al-Ali",
"Raseena M. Haris",
"Younes Akbari",
"Moutaz Saleh",
"Somaya Ali Al-Maadeed",
"Rajesh Kumar M"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cluster Computing | 1386-7857 | Springer Science+Business Media | hybrid | https://doi.org/10.1007/s10586-024-04748-1 | https://doi.org/10.1007/s10586-024-04748-1 | https://openalex.org/W4404761309 | 2024-11-27 |
The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications | This review explores the critical function of the evolutionarily conserved ChaClike enzyme family as central regulators of intracellular glutathione (GSH) homeostasis, focusing on the mammalian isoforms CHAC1 and CHAC2. We detail how these γ-glutamylcyclotransferases degrade GSH, thereby modulating cellular redox balan... | [
"Emma Schröder",
"Tida Viola Jalilvand",
"Kahl Janina",
"Charlotte Sophia Kaiser",
"Eva Liebau"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Frontiers in Molecular Biosciences | 2296-889X | Frontiers Media | gold | https://doi.org/10.3389/fmolb.2025.1724944 | https://doi.org/10.3389/fmolb.2025.1724944 | https://openalex.org/W4417447982 | 2025-12-18 |
Dual human lung models reveal compartment-specific activity of anti-tuberculosis drugs and host-directed therapies | Tuberculosis (TB) remains a major global health challenge that requires new therapeutic strategies to improve drug efficacy, shorten treatment duration, prevent drug resistance, and limit Mycobacterium tuberculosis (Mtb) persistence. Here, we established complementary in vitro human lung models integrating alveolar mac... | [
"Caio César Barbosa Bomfim",
"Natacha Faivre",
"Thomas Benoist",
"Manon Popis",
"Bastien Suire",
"David Péricat",
"José Manuel Sánchez-López",
"Beatriz Melissa Aponte-Castillo",
"Emmanuelle Näser",
"Pénélope Viana",
"Nicolas Marie Guibert",
"Romain Verge",
"Julien Mazières",
"Arnaud Métais... | cc-by | https://creativecommons.org/licenses/by/4.0/ | Microbiology Spectrum | 2165-0497 | American Society for Microbiology | gold | https://doi.org/10.1128/spectrum.03729-25 | https://doi.org/10.1128/spectrum.03729-25 | https://openalex.org/W4416119758 | 2025-11-11 |
Tank-binding kinase 1 regulates inflammation and autophagy in glaucoma | TANK-binding kinase (TBK1) copy number variations have been identified as a monogenic cause of familial normal tension glaucoma (NTG). While elevated intraocular pressure (IOP) is a common risk factor in primary open angle glaucoma (POAG), NTG develops in the absence of IOP elevation. The current available standard of ... | [
"Autumn B. Morgan",
"Denise M. Inman"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Frontiers in Neuroscience | 1662-453X | Frontiers Media | gold | https://doi.org/10.3389/fnins.2025.1735403 | https://doi.org/10.3389/fnins.2025.1735403 | https://openalex.org/W7118696679 | 2026-01-06 |
Canonical NF-κB Pathway as a Central Regulator of Obesity-Associated Inflammation: A Narrative Review | Obesity is characterized by a chronic inflammation driven primarily by sustained activation of the canonical NF-κB signaling pathway. This persistent inflammatory state originates in hypertrophic adipose tissue and progressively affects multiple organ systems, contributing to systemic metabolic dysfunction. This review... | [
"Flavia Medana Anghel",
"Sergiu-Ciprian Matei",
"Gheorghe‐Emilian Olteanu",
"Robert Alexandru Barna",
"Cătălin Marian"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Biomedicines | 2227-9059 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/biomedicines13123050 | https://doi.org/10.3390/biomedicines13123050 | https://openalex.org/W4417244812 | 2025-12-11 |
Wearable Electrochemical Biosensors for Monitoring and Management of Chronic Wounds | Chronic wounds constitute a major global public health challenge, characterized by a high risk of infection, prolonged healing times, and frequent recurrence. Conventional wound assessment methods, which primarily rely on visual clinical inspection and laboratorybased analyses, are limited by inherent subjectivity, del... | [
"Lingxia Zuo",
"Yinbing Liu",
"Jianrong Zhang",
"Linlin Wang",
"Jun-Jie Zhu"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Biosensors | 2079-6374 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/bios15120785 | https://doi.org/10.3390/bios15120785 | https://openalex.org/W4417056948 | 2025-12-01 |
Adapting to living with systemic autoimmune rheumatic diseases; a qualitative exploration of patient and clinician perspectives | Systemic autoimmune rheumatic diseases (SARDs) have widespread symptoms and negatively impact lives in multiple domains. This study explores self-management and coping strategies, and patient and clinician perspectives on adapting to living with a SARD. Semi-structured, in-depth interviews were conducted with patients ... | [
"Alice Tunks",
"Martha Piper",
"Sean Humfrey",
"Ellie Dalby",
"Lucy Calderwood",
"Kaira Naidu",
"Sydnae Taylor",
"R. Li",
"Shihab Ahmed",
"Wendy Diment",
"Michael Bosley",
"Miranda Van Emmenis",
"Felix Naughton",
"Sam Norton",
"Mandy Cousins",
"David P. D’Cruz",
"Melanie Sloan"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Rheumatology International | 0172-8172 | Springer Science+Business Media | hybrid | https://doi.org/10.1007/s00296-025-06033-9 | https://doi.org/10.1007/s00296-025-06033-9 | https://openalex.org/W4417361530 | 2025-12-15 |
The real-world relationship between naltrexone/bupropion treatment and weight loss in Canada: A retrospective chart review | This study examined the change in weight at 6 months of naltrexone/bupropion (NB), a combination pharmacological therapy for weight management, in real-world practice in Canada. The study was conducted through an observational, retrospective, single-arm chart review of adult patients who attended the Wharton Medical Cl... | [
"Sean Wharton",
"Elham Kamran",
"Lehana Thabane",
"Peter Yin",
"Rebecca A. G. Christensen"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Clinical Obesity | 1758-8103 | Wiley | hybrid | https://doi.org/10.1111/cob.12724 | https://doi.org/10.1111/cob.12724 | https://openalex.org/W4404936516 | 2024-12-01 |
Feasibility and Preliminary Efficacy of Enhanced Midwifery Care to Support Women Experiencing Subclinical Depression: A Pilot Randomised Controlled Trial | This study investigated the feasibility and preliminary effects of enhanced midwifery care in reducing subclinical depression symptoms among women in ethnically diverse areas of the South Western Sydney Local Health District (SWSLHD). A pilot randomised controlled trial was conducted among pregnant women attending the ... | [
"James Rufus John",
"Wendy Pickup",
"Antonio Mendoza Diaz",
"Sara Cibralic",
"Aleisha Heys",
"Virginia A. Schmied",
"Bryanne E. W. Barnett",
"Valsamma Eapen"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | International Journal of Environmental Research and Public Health | 1660-4601 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/ijerph22121835 | https://doi.org/10.3390/ijerph22121835 | https://openalex.org/W4417124808 | 2025-12-08 |
Real-world efficacy and safety of dupilumab in the treatment of head and neck atopic dermatitis: a retrospective cohort study | Background: Head and neck atopic dermatitis (HNAD) is a clinically common subtype of AD. While dupilumab is widely used in AD treatment, its efficacy in HNAD is debatable. Objective: This study aimed to evaluate the real-world efficacy and safety of dupilumab in HNAD. Methods: A retrospective study included 29 individu... | [
"Zifan Li",
"Junsheng Peng",
"Ruoxi Yu",
"Ying‐Chi Lin"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Frontiers in Medicine | 2296-858X | Frontiers Media | gold | https://doi.org/10.3389/fmed.2025.1705374 | https://doi.org/10.3389/fmed.2025.1705374 | https://openalex.org/W4416772109 | 2025-11-27 |
The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications | GLP-1 receptor agonist (GLP-1RA) medications have transformed the treatment of type 2 diabetes (T2D) and obesity, with robust evidence for cardiovascular and renal benefits. Nevertheless, GLP-1RA therapy is associated with a pattern of adverse events affecting their safety and tolerability. Here, we delineate mechanism... | [
"Ryan J. Jalleh",
"Nicholas Joseph Talley",
"Michael Horowitz",
"Michael Albrecht Nauck"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Journal of Clinical Investigation | 0021-9738 | American Society for Clinical Investigation | gold | https://doi.org/10.1172/jci194740 | https://doi.org/10.1172/jci194740 | https://openalex.org/W7128962556 | 2026-02-15 |
Moderate to Severe Acute Migraine Attacks: An Opinion Paper on the Use of Triptans and Triptan‑NSAIDs Combinations in Individualized Treatment Plans | This opinion paper on the acute treatment of migraine addresses the definition and recognition of acute migraine attacks, highlighting the variety of symptoms and manifestations. It describes the available treatments and guidelines, noting significant country-specific variations. The paper also discusses the prescriber... | [
"Peter James Goadsby",
"Alexandra Jean Sinclair",
"Shazia K. Afridi",
"Christian Lucas",
"Jérôme Mawet",
"Michel Lantéri‐Minet",
"Xavier Moisset",
"Hans‐Christoph Diener",
"Charly Gaul",
"Tim Patrick Jürgens",
"Marja‐Liisa Sumelahti",
"Margarita Sánchez del Río",
"Patricia Pozo‐Rosich",
"A... | cc-by-nc | https://creativecommons.org/licenses/by-nc/4.0/ | Neurology and Therapy | 2193-6536 | Adis, Springer Healthcare | gold | https://doi.org/10.1007/s40120-025-00874-z | https://doi.org/10.1007/s40120-025-00874-z | https://openalex.org/W4417449086 | 2025-12-18 |
Unraveling the Association Between Fibromyalgia and Irritable Bowel Syndrome: A Systematic Review | Fibromyalgia (FM) and irritable bowel syndrome (IBS) often occur together. Patients with FM and IBS present similar symptoms, such as pain and fatigue; this leads to a delay in diagnosis and management. This systematic review explored the shared pathophysiology of these conditions in adults, focusing on the roles of im... | [
"Roshitha S Bheemaneni",
"Priyanka Sakarkar",
"Aahana Nigam",
"Evangeline C Nwachukwu",
"Sandeep Sekar Lakshmisai",
"Lubna Mohammed"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cureus | 2168-8184 | Cureus, Inc. | diamond | https://doi.org/10.7759/cureus.96801 | https://doi.org/10.7759/cureus.96801 | https://openalex.org/W4416194045 | 2025-11-13 |
Longitudinal Proteomics Analysis of Cerebrospinal Fluid in Survivors of Childhood Acute Lymphoblastic Leukemia | Mass spectrometry-based proteomic profiling of cerebrospinal fluid (CSF) in large patient cohorts, particularly among childhood cancer survivors, remains scarce, limiting opportunities for benchmarking, method development, and validation. Here, we present a longitudinal CSF proteomics dataset from survivors of childhoo... | [
"Mingming Niu",
"Him K. Shrestha",
"Hong Wang",
"Xusheng Wang",
"Kevin R. Krull",
"Junmin Peng"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Scientific Data | 2052-4463 | Nature Portfolio | gold | https://doi.org/10.1038/s41597-026-07326-9 | https://doi.org/10.1038/s41597-026-07326-9 | https://openalex.org/W7158658962 | 2026-04-29 |
Data-Driven Patient Engagement to Improve Medication Adherence: A Narrative Review of Targeted Outreach Across Health Systems | Medication nonadherence undermines chronic disease control and generates avoidable morbidity, mortality, and costs. Between 2010 and 2020, globally, approximately 27% to 40% of patients prescribed antihypertensive therapy were not adherent; poor adherence was associated with 38% higher hospitalization ‐ and mortality r... | [
"Chibuzo O Onah",
"Okoye Augustine Chukwuemeka",
"Taofeek Adeshina Yusuff",
"Edidiong E Abraham",
"Mwidy Sava Mounange-Badimi",
"Tosin Ayodeji Oladosu",
"Izuchukwu F. Okpalanwaka"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cureus | 2168-8184 | Cureus, Inc. | diamond | https://doi.org/10.7759/cureus.95928 | https://doi.org/10.7759/cureus.95928 | https://openalex.org/W4415772308 | 2025-11-02 |
Toward AI-Ready Medical Imaging Data | Medical imaging data plays a vital role in disease diagnosis, monitoring, and clinical research discovery. However, the complexity of medical imaging data, along with site-specific variations in data acquisition and metadata handling, presents challenges for multi-institutional collaboration and downstream analysis. Bi... | [
"Milen Nikolov",
"Edilberto Amorim",
"John Harry Caufield",
"Nayoon Gim",
"Nomi L. Harris",
"Jared Houghtaling",
"Xiang Li",
"Danielle Morrison",
"Anaïs Rameau",
"Jamie Shaffer",
"Hari Trivedi",
"Monica C. Muñoz-Torres"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | arXiv (Cornell University) | 2331-8422 | Cornell University | green | https://doi.org/10.48550/arxiv.2512.03541 | http://arxiv.org/abs/2512.03541 | https://openalex.org/W4417030001 | 2025-12-03 |
Osmolality of oral liquid medications intended for neonates and infants: a laboratory‑based study | Oral liquid medications (OLMs) for neonatal use are recommended to have an osmolality of ≤ 450 mOsm/kg to minimize gastrointestinal risks, specifically necrotizing enterocolitis. However, manufacturers and compounders rarely provide osmolality values. This study measured the osmolality of OLMs commonly used in neonatal... | [
"Dotan Shaniv",
"Shay Teitlboim",
"Hilla Kramer-Haimovich",
"Yael Goldwaser",
"Ilan Matok",
"Amichai Perlman",
"Calanit Hershkovich–Shporen"
] | cc-by-nc | https://creativecommons.org/licenses/by-nc/4.0/ | Drugs & Therapy Perspectives | 1172-0360 | Adis, Springer Healthcare | hybrid | https://doi.org/10.1007/s40267-025-01205-w | https://doi.org/10.1007/s40267-025-01205-w | https://openalex.org/W4415872449 | 2025-11-04 |
Laboratory Evaluation of Peripheral Blood Involvement in Mycosis Fungoides and Sézary Syndrome: Evolution of Flow Cytometry and Morphology Quantification and Interpretation | Mycosis fungoides (MF) and Sézary syndrome (SS) are cutaneous T-cell lymphomas (CTCLs) with variable clinical outcomes. Peripheral blood (PB) involvement in MF/SS is an independent predictor of prognosis. Accurate laboratory determination of PB involvement by MF/SS cells, however, is an ongoing challenge. Both flow cyt... | [
"Lucy Fu",
"Payton Fors Trimark",
"Yijie Liu",
"Hamza Tariq",
"Qing Ching Chen",
"Yi-Hua Chen",
"Juehua Gao",
"Barina Aqil",
"Joan Guitart",
"Kristy Lucile Wolniak"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cancers | 2072-6694 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/cancers18030434 | https://doi.org/10.3390/cancers18030434 | https://openalex.org/W7126042498 | 2026-01-29 |
Statistical and qualitative analysis of ChatGPT and human raters in preservice teachers’ writing assessment | Teachers spend a significant amount of time providing feedback. This study compared expert and ChatGPT assessments and feedback on written texts to determine the suitability of AI for writing skill assessments that are time-consuming to assess and provide feedback. Three experts and ChatGPT graded 14 Turkish undergradu... | [
"Bahadır GÜLDEN",
"Huzeyfe Bilge",
"Pınar Kanık Uysal"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | International Journal of Assessment Tools in Education | 2148-7456 | International Journal of Assessment Tools in Education | diamond | https://doi.org/10.21449/ijate.1678002 | https://doi.org/10.21449/ijate.1678002 | https://openalex.org/W7118891778 | 2026-01-02 |
Unplanned Cesarean for Abnormal or Indeterminate Fetal Heart Tracing Varies Significantly by Race and Ethnicity | The US maternity care system achieves worse outcomes for birthing people identifying as Black versus White. Assessment of fetal well-being in labor is an area of perinatal care subject to significant interobserver variability and therefore may be at particular risk of medical racism influencing care. Statewide collabor... | [
"Elizabeth Suzanne Langen",
"Althea Bourdeau",
"Jessi Ems",
"Eliza Wilson‐Powers",
"Lisa Kane Low"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Journal of Midwifery & Women s Health | 1526-9523 | Wiley | hybrid | https://doi.org/10.1111/jmwh.13720 | https://doi.org/10.1111/jmwh.13720 | https://openalex.org/W4405545067 | 2024-12-18 |
Mesenchymal stem cell therapy for an pulmonary hypertension: update | Pulmonary Hypertension (PH) is a life-threatening condition characterized by pulmonary vascular remodeling. Without treatment, it may progress to right heart failure, the main cause of death in such cases. Although traditional drugs can slow PH progression, their efficacy is often limited, underscoring an urgent need f... | [
"Renmei Tian",
"Shangfu Xu",
"Chan Liu",
"Yuying Wang",
"Yutong Wu",
"Lisheng Li",
"Juan Liu"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Frontiers in Bioengineering and Biotechnology | 2296-4185 | Frontiers Media | gold | https://doi.org/10.3389/fbioe.2025.1692396 | https://doi.org/10.3389/fbioe.2025.1692396 | https://openalex.org/W4416676774 | 2025-11-25 |
Case report of fatal myocarditis with toripalimab and axitinib combination therapy | Cardiac immune-related adverse events (irAEs) are rare but potentially life-threatening complications of immune checkpoint inhibitor (ICI) therapy, with myocarditis associated with particularly high mortality even under aggressive treatment. A 65-year-old male with advanced clear cell renal cell carcinoma and liver met... | [
"Zhengxin Liu",
"Jinyu Tian",
"Shengjie Zeng",
"Chuan Liu"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Medicine | 0025-7974 | Wolters Kluwer | gold | https://doi.org/10.1097/md.0000000000046439 | https://doi.org/10.1097/md.0000000000046439 | https://openalex.org/W7117307469 | 2025-12-26 |
Beyond the Black Box: Theory and Mechanism of Large Language Models | The rapid emergence of Large Language Models (LLMs) has precipitated a profound paradigm shift in Artificial Intelligence, delivering monumental engineering successes that increasingly impact modern society. However, a critical paradox persists within the current field: despite the empirical efficacy, our theoretical u... | [
"Zeyu Gan",
"Ruifeng Ren",
"Wei Yao",
"Xiaolin Hu",
"Gengze Xu",
"Chen Qian",
"Huayi Tang",
"Zixuan Gong",
"Xinhao Yao",
"Peng Tang",
"Z. L. Dou",
"Yong Liu"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | arXiv (Cornell University) | 2331-8422 | Cornell University | green | https://doi.org/10.48550/arxiv.2601.02907 | http://arxiv.org/abs/2601.02907 | https://openalex.org/W7119206146 | 2026-01-06 |
Effects of aquatic exercise on arterial stiffness and endothelial function in adults: A systematic review and meta-analyses | Objective: To evaluate the effects of aquatic exercise compared with non-exercise controls and land-based exercise on arterial stiffness and endothelial function. Design: Systematic review and meta-analyses of randomized controlled trials assessed using the Cochrane risk-of-bias tool and Grading of Recommendations Asse... | [
"Emily Dunlap",
"Yanbing Zhou",
"Manny M. Y. Kwok",
"Billy C. L. So",
"Hirofumi Tanaka"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | PLoS ONE | 1932-6203 | Public Library of Science | gold | https://doi.org/10.1371/journal.pone.0338929 | https://doi.org/10.1371/journal.pone.0338929 | https://openalex.org/W4417304310 | 2025-12-12 |
Targetable Vulnerabilities in MYC‐Driven B Cell Lymphomas Resistant to BCR Extinction | Polatuzumab vedotin, an antibody‐drug conjugate (ADC) targeting the B cell receptor (BCR) signaling subunit CD79B, has recently entered frontline therapy for diffuse large B cell lymphoma (DLBCL) and high‐grade B cell lymphoma (HGBCL), achieving encouraging clinical results. However, MYC‐driven B cell lymphomas, partic... | [
"Silvia Brambillasca",
"Nicara C. Parr",
"Adriana Palmeri",
"Adrian Andronache",
"Hiroshi Arima",
"Giovanni Fagà",
"Brian Leuzzi",
"Laura Perucho",
"Michela Robusto",
"Maurizio Pasi",
"Federica Mainoldi",
"Daniele Fancelli",
"Mario Varasi",
"Gabriele Varano",
"Ciro Mercurio",
"Stefano ... | cc-by | https://creativecommons.org/licenses/by/4.0/ | Hematological Oncology | 0278-0232 | Wiley | hybrid | https://doi.org/10.1002/hon.70175 | https://doi.org/10.1002/hon.70175 | https://openalex.org/W7128519001 | 2026-02-11 |
Fruquintinib saddles tumor immune tolerance by curbing pro-tumoral immature myeloid cell populations | Myeloid-derived cells, particularly immature populations and tumor-associated macrophages, play a pivotal role in establishing immune tolerance and suppressing antitumor responses, thereby promoting cancer progression. Macrophage-derived lymphatic endothelial cell progenitors (MLECP) are a population of VEGFR3/FLT4/CD3... | [
"Lucía Suárez",
"María Martínez-Azcona",
"Irantzu Serrano-Mendioroz",
"Leticia Fernández",
"Maria Esperanza Rodriguez-Ruiz",
"Ana Rouzaut"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Frontiers in Immunology | 1664-3224 | Frontiers Media | gold | https://doi.org/10.3389/fimmu.2025.1699980 | https://doi.org/10.3389/fimmu.2025.1699980 | https://openalex.org/W4417221641 | 2025-12-11 |
Improving retinal vessel assessment precision by integrating deep learning with interactive editing and graphical modeling | We present the SEoul Retinal Vessel Assessment Library (SERVAL), a novel software platform for precise quantitative measurement of vascular structures in fundus images. SERVAL integrates deep learning-based automatic artery and vein mask initialization, subpixel vessel centerline and boundary refinement, and interactiv... | [
"Sojung Go",
"Jaemin Chae",
"Uichan Kim",
"Jongsoo Lim",
"Joo‐Young Kim",
"Stephen Hogg",
"Emanuele Trucco",
"Sang Jun Park",
"Soochahn Lee"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Scientific Reports | 2045-2322 | Nature Portfolio | gold | https://doi.org/10.1038/s41598-025-25421-6 | https://doi.org/10.1038/s41598-025-25421-6 | https://openalex.org/W4416594361 | 2025-11-24 |
Investigation of the relationship of sleep disorder occurring in fibromyalgia with central nervous system and pineal gland volume | Objective: Mechanisms of sleep disorders in fibromyalgia (FM) patients, such as insomnia, early morning awakenings and poor quality sleep, have not yet been proven and no consistent and effective treatment is yet available. The aim of this study was to investigate the pineal gland volume and the relationship between to... | [
"Fatih Çiçek",
"İlyas Uçar",
"Turgut Seber",
"Fatma Gül Ülkü Demir",
"Ali Türker ÇİFTÇİ"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Acta Neuropsychiatrica | 0924-2708 | Cambridge University Press | hybrid | https://doi.org/10.1017/neu.2024.49 | https://doi.org/10.1017/neu.2024.49 | https://openalex.org/W4404220839 | 2024-11-11 |
Surgery for intracerebral hemorrhage: new evidence and changing perspectives | Spontaneous intracerebral hemorrhage (ICH) remains the most devastating form of stroke, with limited evidence supporting surgical intervention. Traditional craniotomy has shown no clear benefit in improving long-term outcomes, largely due to procedural invasiveness, delayed timing, and heterogeneous patient selection. ... | [
"Airton Leonardo de Oliveira Manoel",
"Ali Msheik",
"Sophie Schuind",
"Ghaya Al Rumaihi",
"Fabio Silvio Taccone"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Critical Care | 1364-8535 | BioMed Central | gold | https://doi.org/10.1186/s13054-025-05763-3 | https://doi.org/10.1186/s13054-025-05763-3 | https://openalex.org/W4416839663 | 2025-12-01 |
Exploring perceptions of alternative assessment and grading in graduate anatomy education | Alternative assessment approaches, such as pass/fail and feedback-based designs, aim to reduce academic stress and foster deeper learning. Few studies have examined feedback-based evaluation in formative settings in medical education, but none among graduate anatomy students. This exploratory study investigated the i... | [
"E Dietrich",
"Sean C. McWatt"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Anatomical Sciences Education | 1935-9772 | Wiley | hybrid | https://doi.org/10.1002/ase.2550 | https://doi.org/10.1002/ase.2550 | https://openalex.org/W4405948503 | 2024-12-31 |
Multi-kingdom gut microbiota characterization in Chinese patients with idiopathic inflammatory myopathies | Idiopathic inflammatory myopathies (IIMs) are systemic autoimmune disorders with unknown etiology. Despite the established link between gut microbes and immunity, the roles of gut bacteriome, mycobiome, and virome in IIM are unexplored. We performed shotgun metagenomic sequencing on fecal samples from 34 IIM patients a... | [
"Changli Liu",
"Yida Xing",
"Jinwen Su",
"Yiping Liu",
"Yuemeng Dou",
"Zheng Wang",
"Shanshan Sha",
"Qiulong Yan",
"Mingxi Xu",
"Lin Zhao",
"Yi Tian",
"Guorui Xing",
"Shenghui Li",
"Jian Kang",
"Xiaodan Kong"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Scientific Reports | 2045-2322 | Nature Portfolio | gold | https://doi.org/10.1038/s41598-025-33939-y | https://doi.org/10.1038/s41598-025-33939-y | https://openalex.org/W7118642059 | 2026-01-07 |
The role of external-beam radiotherapy for differentiated thyroid cancer | The treatment options for differentiated thyroid cancer (DTC) are surgery, thyroid stimulating hormone suppression, radioactive iodine, and multitargeted tyrosine kinase inhibitors. The role of external-beam radiotherapy (EBRT) for DTC is controversial because of the lack of randomized controlled trials, but prospectiv... | [
"Terufumi Kawamoto",
"Naoto Shikama",
"Naoki Nakamura",
"Takashi Mizowaki"
] | cc-by-nc | https://creativecommons.org/licenses/by-nc/4.0/ | Japanese Journal of Clinical Oncology | 0368-2811 | Oxford University Press | hybrid | https://doi.org/10.1093/jjco/hyae158 | https://doi.org/10.1093/jjco/hyae158 | https://openalex.org/W4404054008 | 2024-11-05 |
Accuracy is not enough: explainable boosting machine model and identification of candidate biomarkers for real-time sepsis risk assessment in the emergency department | Sepsis poses a significant threat in emergency settings, necessitating tools for early and interpretable risk assessment. This study aimed to develop a robust explainable boosting machine (EBM) model, one of the explainable artificial intelligence (XAI) technologies, to construct a predictive model that balances high a... | [
"Fatma Hilal Yağın",
"Umran Aygun",
"Cemil Çolak",
"Amal Khalifa Alkhalifa",
"Sarah A. Alzakari",
"Mohammadreza Aghaei"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | BMC Emergency Medicine | 1471-227X | BioMed Central | gold | https://doi.org/10.1186/s12873-025-01402-w | https://doi.org/10.1186/s12873-025-01402-w | https://openalex.org/W4416789332 | 2025-11-28 |
Sexually dimorphic responses in androgen metabolism and signalling in the non-human primate placenta to moderate maternal undernutrition | Maternal nutrient restriction (MNR) can increase maternal androgen concentrations during pregnancy and cause placental dysfunction leading to reduced fetal growth, especially in males. Placental androgen metabolism, as well as differential expression and subcellular localisation of androgen receptor (AR) variants, modu... | [
"Ashley S. Meakin",
"Peter W. Nathanielsz",
"Cun Li",
"Vicki Lee Clifton",
"Hillary F. Huber",
"Michael David Wiese",
"Janna Leigh Morrison"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Biology of Sex Differences | 2042-6410 | BioMed Central | gold | https://doi.org/10.1186/s13293-025-00771-y | https://doi.org/10.1186/s13293-025-00771-y | https://openalex.org/W4415996745 | 2025-11-07 |
Beyond pediatric nutritional diagnosis and care | In Mexico, the National Health and Nutrition Surveys (ENSANUT) have highlighted key trends in childhood malnutrition, dietary habits, the role of family members in nutrition, and the nutritional status of hospitalized children. According to the 2023 ENSANUT reported a prevalence of chronic malnutrition of 13.9% in chil... | [
"Jimena Fuentes-Cummings",
"Viridiana Montsserrat Mendoza-Martínez",
"Nallely Bueno-Hernández"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Revista Médica Del Hospital General De México | 0185-1063 | Elsevier BV | diamond | https://doi.org/10.24875/hgmx.25000042 | https://doi.org/10.24875/hgmx.25000042 | https://openalex.org/W4414764358 | 2025-10-02 |
Ultrasonographic Measurement of Skin to Lumbar Epidural Space Depth in Pregnant Women Undergoing Elective Cesarean Section: An Observational Study | Neuraxial anesthesia is commonly used during cesarean delivery and is preferred for its effectiveness and minimal risks. Accurate identification of the depth of the lumbar epidural space is crucial to ensure successful block and minimize complications. However, this can be challenging in pregnant women due to physiolog... | [
"Sushila Lama Moktan",
"Milan Kumar Thapa",
"Ujma Shrestha",
"Prabin Subedi"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Journal of Nepal Medical Association | 0028-2715 | Nepal Medical Association | diamond | https://doi.org/10.31729/jnma.8861 | https://doi.org/10.31729/jnma.8861 | https://openalex.org/W4405956382 | 2024-12-31 |
Disrupting CDK9 activity suppresses triple-negative breast cancer and is enhanced by EGFR Inhibition | CDK9, in complex with cyclin T1 or T2, is essential for mRNA transcription by enabling paused RNA polymerase II to proceed into elongation. Increasing evidence highlights CDK9’s involvement in transcriptional addiction in cancer. Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype for which effe... | [
"Vera E. van der Noord",
"Ronan P. McLaughlin",
"Jessica S. Karuntu",
"Jichao He",
"A. Mieke Timmermans",
"Sunita K. C. Basnet",
"Yi Long",
"Sarah Al Haj Diab",
"Solomon Asmamaw Tadesse",
"Natalie Proost",
"Bastiaan van Gerwen",
"Bjørn Siteur",
"Marieke van de Ven",
"Chantal Pont",
"Sylv... | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cellular Oncology | 1570-5870 | Springer Nature | gold | https://doi.org/10.1007/s13402-025-01154-6 | https://doi.org/10.1007/s13402-025-01154-6 | https://openalex.org/W7119479357 | 2026-01-08 |
Large Language Models and Innovative Work Behavior in Higher Education Curriculum Development | The growth of generative artificial intelligence (GAI), remarkably, Large Language Models (LLMs) such as ChatGPT, converts the educational environment by empowering intelligent, data-driven education and curriculum design innovation. This study aimed to assess the integration of LLMs into higher education to foster cur... | [
"Ibrahim Abdelhamid Elshaer",
"Chokri Kooli",
"Alaa M. S. Azazz",
"Mansour Abdullah Alyahya"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Administrative Sciences | 2076-3387 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/admsci16010056 | https://doi.org/10.3390/admsci16010056 | https://openalex.org/W7125582670 | 2026-01-22 |
Hevin Promotes Aging-Related Cardiac Dysfunction via Facilitating Cardiac Inflammation in Male Mice | As individuals age, there is a gradual increase in the levels of inflammation in the body, with macrophages, essential immune cell types, assuming a critical role in modulating inflammatory responses and eliminating senescent cells. Prolonged inflammatory reactions can result in tissue damage, the advancement of diseas... | [
"Sicong Huang",
"Yu‐Jie Chen",
"Yu‐Xin Hu",
"Jia‐Chen Liu",
"Min Hu"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Aging Cell | 1474-9718 | Wiley | gold | https://doi.org/10.1111/acel.70369 | https://doi.org/10.1111/acel.70369 | https://openalex.org/W7122693482 | 2026-01-11 |
Brentuximab Vedotin in Advanced-Stage Mycosis Fungoides/Sézary Syndrome with Low CD30 Expression: Real-World Data from the German Cutaneous Lymphoma Network | Background/Objectives: Advanced-stage mycosis fungoides (MF) and Sézary syndrome (SS) are aggressive forms of cutaneous T-cell lymphoma (CTCL) for which treatment options are limited and prognosis is poor. Brentuximab vedotin (BV), an anti-CD30 antibody–drug conjugate, has demonstrated high response rates in patients w... | [
"Christoph Blazejak",
"Mathias Oymanns",
"René Stranzenbach",
"Uwe Hillen",
"Christina Mitteldorf",
"Jan Peter Nicolay",
"Marion Wobser",
"Philipp Schrüfer",
"Janika Gosmann",
"Ulrike Wehkamp",
"Nina Booken",
"Alexander Kreuter",
"Edgar Dippel",
"Claus‐Detlev Klemke",
"Maria Weyermann",
... | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cancers | 2072-6694 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/cancers18010097 | https://doi.org/10.3390/cancers18010097 | https://openalex.org/W7117461707 | 2025-12-28 |
Machine Learning-Based Prediction of Decompensation in Hepatitis B Virus-Related Cirrhosis | Fatality of cirrhotic patients greatly increases when they progress to the decompensated state. Only a few studies to date have applied machine learning (ML) methods to predict decompensation in cirrhosis patients. In the present study, we attempted to apply self-developed ML models for validating their capability of p... | [
"Hsueh-Chun Lin",
"M.-Y. Hsieh",
"Mengyu Liu",
"Chin‐Chi Kuo",
"Shwn‐Huey Shieh",
"Ming‐Shun Hsieh",
"Vivian Chia‐Rong Hsieh"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Diagnostics | 2075-4418 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/diagnostics15212790 | https://doi.org/10.3390/diagnostics15212790 | https://openalex.org/W4415870719 | 2025-11-04 |
The effects of short- and long-duration Kangaroo Mother Care and conventional care on improving weight gain in low birth weight infants: a systematic review and meta-analysis | Kangaroo Mother Care (KMC) is a cornerstone intervention in neonatal care, widely recognized for its capacity to reduce morbidity and mortality in vulnerable newborns. Its simplicity, low cost, and adaptability make it especially valuable in resource-limited settings, where conventional neonatal intensive care may not ... | [
"Zhijia Gong",
"Jiao He",
"Li Zhang"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | BMC Pediatrics | 1471-2431 | BioMed Central | gold | https://doi.org/10.1186/s12887-025-06267-3 | https://doi.org/10.1186/s12887-025-06267-3 | https://openalex.org/W4416070185 | 2025-11-10 |
Genetic and functional analyses of SPTLC1 in juvenile amyotrophic lateral sclerosis | Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of the motor system. Pathogenic variants in SPTLC1, encoding a subunit of serine palmitoyltransferase, cause hereditary sensory and autonomic neuropathy type 1 (HSAN1), and have recently been associated with juvenile ALS. SPTLC1 variants as... | [
"Susumu OKUBO",
"Hiroya Naruse",
"Hiroyuki Ishiura",
"Atsushi Sudo",
"Kayoko Esaki",
"Jun Mitsui",
"Takashi Matsukawa",
"Wataru Satake",
"Peter Greimel",
"Nanoka Shingai",
"Yasushi Oya",
"Takeo Yoshikawa",
"Shoji Tsuji",
"Tatsushi Toda"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Journal of Neurology | 0012-1037 | Springer Science+Business Media | hybrid | https://doi.org/10.1007/s00415-024-12776-5 | https://doi.org/10.1007/s00415-024-12776-5 | https://openalex.org/W4405323671 | 2024-12-12 |
Correction of profound hyponatraemia following rapid bolus therapy: effectiveness of the Barsoum–Levine formula based on the Edelman equation | Background. The optimal treatment for profound hyponatraemia remains uncertain. Recent clinical studies have demonstrated that a standardized bolus of hypertonic saline is effective, but relying solely on this approach may not fully address the individual variability of hyponatraemia among patients. We evaluated the ef... | [
"Koya Nagase",
"Takahiro Imaizumi",
"Atsushi Yamamori",
"Yuna Hiramatsu",
"Minori Kambe",
"Youngjoo Kang",
"Yukari Kishima",
"Yoshiaki Kozaki",
"Fumika N. Nagase",
"Keita Iwasaki",
"Yuuki Ito",
"Hiroki Ikai",
"Mari Yamamoto",
"Yukari Murai",
"Waka Yokoyama-Kokuryo",
"Naoho Takizawa",
... | cc-by-nc | https://creativecommons.org/licenses/by-nc/4.0/ | Clinical Kidney Journal | 2048-8505 | Oxford University Press | gold | https://doi.org/10.1093/ckj/sfae402 | https://doi.org/10.1093/ckj/sfae402 | https://openalex.org/W4405390817 | 2024-12-13 |
C9orf72-ALS mutation drives basal mitophagy impairments in iNeurons | Introduction: ALS is a neurodegenerative disorder characterized by progressive upper and lower motor neuron loss. A GGGGCC hexanucleotide repeat expansion (HRE) in the C9orf72 gene is the most common mutation found in populations of European descent. Mitochondrial dysfunction has been observed in C9orf72-ALS patients a... | [
"James A. K. Lee",
"Chloé Moutin",
"Sarah M. Granger",
"Katie Roome",
"Allan Christian Shaw",
"Scott P. Allen",
"Laura Ferraiuolo",
"Pamela J. Shaw",
"Heather Mortiboys"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Frontiers in Cellular Neuroscience | 1662-5102 | Frontiers Media | gold | https://doi.org/10.3389/fncel.2026.1731669 | https://doi.org/10.3389/fncel.2026.1731669 | https://openalex.org/W7128592576 | 2026-02-11 |
Transforming Gastric Biopsy Diagnostics: Integrating Omics Technologies and Artificial Intelligence | Gastric biopsy remains central to diagnosing Helicobacter pylori infection, autoimmune gastritis, intestinal metaplasia, dysplasia, and gastric cancer. However, morphology-based assessment is limited by interobserver variability, sampling constraints, and an incomplete ability to capture molecular heterogeneity and pre... | [
"Nasar Alwahaibi"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Biomedicines | 2227-9059 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/biomedicines14020407 | https://doi.org/10.3390/biomedicines14020407 | https://openalex.org/W7128590215 | 2026-02-11 |
Molecular Mechanisms of Rotator Cuff Degeneration Identified by Spatial Transcriptomics and Multiplex Immunofluorescence | Rotator cuff tear (RCT) is a prevalent age‐related condition whose underlying mechanisms remain poorly understood. This study employed spatial transcriptomics and multiplex immunofluorescence (mIF) to investigate gene expression and spatial heterogeneity in rotator cuff tissues from elderly RCT patients compared to age... | [
"Shiyi Yao",
"Renhao Yang",
"Shifeng Ling",
"Gen Li",
"Hao Wang",
"Renxuan Li",
"Yang Xu",
"Yin Zhang",
"Chengyu Zhuang",
"Lei Wang"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Journal of Orthopaedic Research® | 0736-0266 | Wiley | hybrid | https://doi.org/10.1002/jor.70163 | https://doi.org/10.1002/jor.70163 | https://openalex.org/W7132851095 | 2026-02-27 |
Non-Neoformans Cryptococcal Infections in the Post-Coronavirus Disease-19 (COVID-19) Era: Are We Ready to Face the Emerging Challenge? | Coronaviruses are a large group of viruses that infect animals as well as humans, while it is also suggested that, rarely, coronaviruses that infect animals can evolve and infect humans. Current evidence suggests that severe acute respiratory syndrome (SARS) coronavirus-2 leads to coronavirus disease-19 (COVID-19), the... | [
"Umayra Fatima",
"Hina Nabi Ahmed",
"Gautam Singh",
"Kolli Yada Giri",
"Md. Sania Azmi",
"Archana Meenakshi",
"Suresh Babu Jandrajupalli",
"Swarnalatha Chandolu",
"Abhishek Singh Nayyar"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Asian Journal of Neurosurgery | 1793-5482 | Thieme Medical Publishers (Germany) | hybrid | https://doi.org/10.1055/s-0044-1791998 | https://doi.org/10.1055/s-0044-1791998 | https://openalex.org/W4404026997 | 2024-11-04 |
Association between average triglyceride glucose-body mass index and risk of hypertension in middle-aged and elderly Chinese: A study based on Chinese CHARLS cohort data | This study aimed to investigate the relationship between cumulative average triglyceride glucose-body mass index (TyG-BMI) and the risk of developing hypertension among middle-aged and elderly population. Data were sourced from the 2012 and 2015 China Health and Retirement Longitudinal Study. The population was stratif... | [
"Chuanlei Zheng",
"Yanhong Liu",
"Shaobo Zeng",
"Sisi Xie",
"Xuanning Luo",
"Qingfeng Wu"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | PLoS ONE | 1932-6203 | Public Library of Science | gold | https://doi.org/10.1371/journal.pone.0337710 | https://doi.org/10.1371/journal.pone.0337710 | https://openalex.org/W4417004397 | 2025-12-04 |
Advances in Cell-Mediated Drug Delivery for Dermatologic Diseases: Mechanisms and Current Applications | Cell-mediated drug delivery systems represent a promising frontier in dermatologic therapy by offering enhanced targeting precision, prolonged drug release, and reduced systemic toxicity. These systems leverage the intrinsic properties of immune cells, stem cells, and skin-resident cells to migrate toward inflamed or d... | [
"Lara Shqair",
"Iyla Draw",
"Tala Maya",
"Christopher G. Bunick",
"Hossein Akbarialiabad",
"Todd E. Schlesinger",
"Giovanni Battista Damiani",
"Mahmoud Afif Ghannoum",
"Ayman A. Grada"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Pharmaceutics | 1999-4923 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/pharmaceutics17111438 | https://doi.org/10.3390/pharmaceutics17111438 | https://openalex.org/W4415990504 | 2025-11-07 |
Dynamic regulation and targeted intervention of neutrophils in hepatic ischemia‑reperfusion injury (Review) | Ischemia‑reperfusion injury (IRI) is a complex pathophysiological process characterized by oxidative stress, inflammatory response and cell death during tissue reperfusion, leading to organ dysfunction. In liver transplantation, hepatic ischemia‑reperfusion injury (HIRI) can result in irreversible liver failure and sub... | [
"Sen Lu",
"Jiale Tong",
"Jing Jiang",
"Qin Zhang",
"Youjin Huang"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | International Journal of Molecular Medicine | 1107-3756 | Spandidos Publishing | hybrid | https://doi.org/10.3892/ijmm.2026.5780 | https://doi.org/10.3892/ijmm.2026.5780 | https://openalex.org/W7133301833 | 2026-03-03 |
Postbiotics as microbial-derived therapeutics for wound healing disorders: from molecular mechanisms to future application | Skin microbiota emerged as an important factor in modulating all aspects of the wound healing process, with the potential utilization of residing microbes as biological therapeutics. Commensal or probiotic bacteria represent a first layer of the cutaneous barrier protection, inhibiting detrimental effects of pathogens ... | [
"Miroslav Dinić",
"Tammy Gonzalez",
"Melissa Hernandez",
"Dušan Radojević",
"Lauren Fernandez",
"Nataša Golić",
"Irena Pastar"
] | cc-by-nc-nd | https://creativecommons.org/licenses/by-nc-nd/4.0/ | Cell Communication and Signaling | 1478-811X | BioMed Central | gold | https://doi.org/10.1186/s12964-025-02494-4 | https://doi.org/10.1186/s12964-025-02494-4 | https://openalex.org/W4416571215 | 2025-11-24 |
A risk-stratified model for predicting endometrial atypical hyperplasia and cancer to guide biopsy decisions in asymptomatic postmenopausal women | Background: Endometrial atypical hyperplasia (EAH) and endometrial cancer (EC) are increasingly detected in asymptomatic postmenopausal women. This often leads to delayed treatment. Risk stratification remains challenging, and single-factor models may not accurately identify high-risk individuals. This study aimed to d... | [
"Shanshan Wu",
"Xu Zhang",
"Suhan Lai",
"Xiaohui Yang",
"Jing Wan"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Frontiers in Medicine | 2296-858X | Frontiers Media | gold | https://doi.org/10.3389/fmed.2025.1707883 | https://doi.org/10.3389/fmed.2025.1707883 | https://openalex.org/W4417018203 | 2025-12-05 |
A lipid nanoparticle encapsulated CPA-CTD mRNA vaccine provides protection against Clostridium perfringens-driven diseases | Clostridium perfringens (C. perfringens), a ubiquitous Grampositive bacterium in the environment and mammalian gut flora, is a leading cause of enterotoxemia in animals, necrotizing enteritis in humans and animals, and gas gangrene in both, attributed to its diverse exotoxin profile. Alpha-toxin, a pivotal virulence fa... | [
"Qi Jia",
"Haoyu Xiang",
"Ting Le",
"Jing Wang",
"Jitao Chang",
"Fang Wang",
"Chao Sun",
"Wanbo Tai",
"Zhigang Jiang",
"Xin Yin"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Frontiers in Immunology | 1664-3224 | Frontiers Media | gold | https://doi.org/10.3389/fimmu.2025.1748171 | https://doi.org/10.3389/fimmu.2025.1748171 | https://openalex.org/W7118997847 | 2026-01-08 |
The Emerging Role of Transcription-Associated Cyclin-Dependent Kinases in Gastrointestinal Tumors | Transcription‐associated cyclin‐dependent kinases (tCDKs) precisely control the gene transcription process (initiation, elongation, and termination) by mediating RNA polymerase II phosphorylation. In several cancers, disrupted transcriptional control is emerging as a hallmark. In this review we summarize research studi... | [
"Dipti Athavale",
"David Pulipati",
"Curt Balch",
"Junsong Zhao",
"Yan-ting Yann Zhang",
"Xiaodan Yao",
"Shumei Song"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Cancers | 2072-6694 | Multidisciplinary Digital Publishing Institute | gold | https://doi.org/10.3390/cancers18060979 | https://doi.org/10.3390/cancers18060979 | https://openalex.org/W7138837411 | 2026-02-05 |
Structural determinants of HIV inequities in South Africa: Policy analysis of the national strategic plan for HIV 2023–2028 | Background: South Africa continues to experience the world’s highest HIV burden despite major progress in antiretroviral therapy (ART) scale-up. Persistent disparities across gender, geography, and socioeconomic status reveal that structural and political inequities shape vulnerability, access, and outcomes. This paper... | [
"Aqilah A. Julaihi"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | Health Policy OPEN | 2590-2296 | Elsevier BV | gold | https://doi.org/10.1016/j.hpopen.2025.100154 | https://doi.org/10.1016/j.hpopen.2025.100154 | https://openalex.org/W4416420281 | 2025-11-20 |
The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust | The novel South London and Maudsley Brain Health Clinic (SLaM BHC) leverages advances in remote consultations and biomarkers to provide a timely, cost-efficient and accurate diagnosis in mild cognitive impairment (MCI). The SLaM BHC provides a highly acceptable and safe clinical model for remote assessments and lumbar ... | [
"Ashwin V. Venkataraman",
"Pooja Kandangwa",
"Roos Lemmen",
"Rutvi Savla",
"Mazda Beigi",
"Devon Hammond",
"Daniel Harwood",
"Justin Sauer",
"Latha Velayudhan",
"Clive G. Ballard",
"Anna‐Katharine Brem",
"Chris Kalafatis",
"Dag Aarsland"
] | cc-by | https://creativecommons.org/licenses/by/4.0/ | BJPsych Open | 2056-4724 | Cambridge University Press | gold | https://doi.org/10.1192/bjo.2024.829 | https://doi.org/10.1192/bjo.2024.829 | https://openalex.org/W4405604410 | 2024-12-19 |
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