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[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...
[ { "role": "system", "content": "You are solving a task in the \"ACMG Variant Classification\" domain.\n\nThink step by step inside a <reasoning> ... </reasoning> block, then output your\nfinal answer as a single JSON object inside a <decision> ... </decision> block.\n\nThe JSON object MUST contain:\n - \"c...

AmberTrace — ACMG Variant Classification

Clinical variant classification over ACMG evidence criteria. Features and prompts only — classifications are obtained live from AmberTrace.

AT = gold — this dataset ships no answers

The AmberTrace verifier is the answer. Every certified-answer column (gold / oracle / decision / triage_reason / undecidable) has been stripped from these files: a public (features → certified decision) map would give the decision function away and let any leaderboard be gamed. Score live by submitting the prompts/features to AmberTrace and reading the certificate at eval time — the verifier is the oracle, not a static key.

Files

File Rows Fields Notes
features.csv 384 null_variant_in_disease_gene, functional_studies_damaging, computational_predicts_damaging, common_in_population, functional_studies_benign, computational_predicts_benign Feature-only evidence table (already answer-free).
train.jsonl 45 prompt GRPO training prompts; the gold ACMG label is stripped.
eval.jsonl 18 prompt Eval prompts; the gold ACMG label is stripped.

Provenance

These platforms were agent-authored via the AmberTrace SDK and acceptance-gated; the prompt/feature files are generated reproducibly from the source repo. See ambertrace-rlvr and its data/ + examples/gen_*.py generators.

Reproduce / score

License

MIT (see the source repo).

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