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CRLM desmoplastic status and survival prediction

Slide-level prediction of desmoplastic histopathological growth pattern (dHGP) status and overall survival (OS) for colorectal liver metastases (CRLM) from hematoxylin and eosin whole slide images (WSI).

Method

The WSI is compressed with the MTDP ResNet50 encoder at spacing 2.0 into a 2048-channel feature map (neural image compression). A gated-attention network then predicts a slide-level output (attention-based multiple instance learning).

Contents

  • paper_models/: 5-fold desmoplastic classifier (No-HGP vs HGP), validation AUC 0.94 to 0.95, plus the shared encoder resnet50-mh-best-191205-141200.pth.
  • os_models/: 5-fold overall survival model, validation c-index 0.63 to 0.67.

Both ensembles share the single MTDP ResNet50 encoder bundled in paper_models/.

Intended use

Research use only. Not a medical device. Not for clinical decision making.

Links

Citation

Confirm the correct paper and MTDP encoder citation with the authors before use.

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