Kir2.1
#1
by biotechnology - opened
The Kir2.1 inward-rectifier potassium ion channel is encoded by the KCNJ2 gene. A mutation in the KCNJ2 gene has been shown to cause short QT syndrome. Expression of Kir2.1 gene in human HEK293 cells induce a transient outward current, creating a steady membrane potential of around -70 mV.
Creative Bioarray currently provides manual patch clamp assay using acutely isolated animal cardiomyocytes or CHO-Kir2.1 cell line to test drug's inhibition or potentiating effect on Ik1 mainly contributed by Kir2.1 channels. This assay is one of the recommended preclinical cardiac safety assays in the pharmaceutical industry.