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Graph-Residual with ESM-2

This repository contains the ESM-2 Graph-Residual implementation and its verified ESM-2 backbone and ResidualV2 adapter checkpoint.

Contents

  • models/esm2/backbone/: ESM-2 8M backbone files and configuration.
  • models/esm2/residual/graph_residual_v2.pt: Graph-Residual ResidualV2 checkpoint.
  • src/: model, graph, training, and evaluation code.
  • configs/: portable ESM-2 and evaluation configurations.

The adapter uses 64-dimensional graph features, a 256-dimensional hidden layer, and 640-dimensional sequence outputs with residual fusion and LayerNorm. Raw datasets, graph databases, logs, and optimizer state are not included.

Intended use

Protein representation adaptation, relation-aware retrieval, and analysis of heterogeneous biological graph context.

Limitations

Compatible graph representation inputs are required. This release is not a universal protein predictor and is not a generic unseen-node inductive model.

Citation

Please cite the associated Graph-Residual / ESM2 V2 manuscript or preprint and the upstream ESM-2 model.

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