Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:12:p4
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 12 (pt 4/7)
Character Range: 2300397–2303703

ADWG (NHMRC 2011)    ADI = 0.24 mg/day or 0.003 mg/kg/day for 70 kg adult                                                        The ADWG (NHMRC 2011) derived a health-based guideline of 0.01 mg/L based on an ADI of 0.24 mg/day derived from review of toxic effects from a 2-year study on 140 people (1991 study). For an adult this is equivalent to an ADI of 0.003 mg/kg/day.
FSANZ (2003 & 2008)  TL = 0.0125 mg/kg/day                                                                                       Tolerable limit (TL) for selenium considered in the evaluation of dietary exposures to selenium in 20th ATDS (FSANZ 2003).
                     UL (infants) = 0.007 mg/kg/day                                                                              Upper limit for infants and adults considered in the 22nd ATDS (FSANZ 2008) based on the evaluation provided by NHMRC (2006). Also note RDI and AI noted below from NHMRC (2006).
                     UL (adults) = 0.4 mg/day equivalent to 0.006 mg/kg/day for 70 kg adult
NHMRC (2006)         AI = 0.0120.015 mg/day for infants                                                                         Upper limit (UL) for infants based on a NOAEL from studies showing human milk concentrations are not associated with adverse effects, and an uncertainty factor of 1. There is no evidence of increased toxicity in older children and adolescents and hence the UL derived for infants is adopted for these age groups.
                     RDI = 0.0250.06 mg/day for children
                     UL = 0.0450.06 mg/day for infants and 0.090.4 mg/day for infants and children, based on 0.007 mg/kg/day.  UL for adults is based on a NOAEL of 0.8 mg/kg/day associated with brittleness and loss of hair and nails, gastrointestinal disturbances, skin rash, fatigue and effects on the nervous system from a population study, and an uncertainty factor of 2 to address sensitive individuals and because of data gaps.
                     RDI = 0.0650.075 mg/day for adults
                     UL = 0.4 mg/day for adults (including pregnant women) equivalent to 0.006 mg/kg/day for 70 kg adult
International
WHO (2011)           UL = 0.4 mg/day                                                                                             The WHO (2011) review has derived a provisional guideline of 0.04 mg/L based on an upper tolerable intake of 0.4 mg/day. The guideline is considered to be provisional due to uncertainties in the scientific database,  however the review notes that it is important to balance recommended intakes with undesirable intakes in setting any guideline level.
CCME (2007)          UL = 0.0055 mg/kg/day for infants                                                                           For potential risks posed at contaminated sites in Canada by exposure to contaminants that are also considered to be essential trace elements, Health Canada recommends the use of 'Tolerable Upper Intake Levels' (ULs) as the reference exposure levels for risk assessment. Since selenium is an essential trace element in human health and selenium compounds do not appear to be carcinogenic, the ULs for all life stage groups are proposed for use in the derivation of the human health soil quality guidelines for selenium. The UL noted here is the