Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:5:p3
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 5 (pt 3/4)
Character Range: 2519459–2523188

mg/kg/day associated liver and kidney effects in a rat study, and an uncertainty factor of 100.
ATSDR (1996)        Oral MRL = 0.0003 mg/kg/day  Chronic oral MRL based on a NOAEL of 0.025 mg/kg/day associated with CNS effects in a 2-year dog study, and an uncertainty factor of 100.
US EPA (IRIS 2012)  RfD = 0.0003 mg/kg/day       Oral RfD based on a NOAEL of 0.025 mg/kg/day associated with liver effects in a 2-year dog study, and an uncertainty factor of 100.

The above evaluations have identified consistent NOAEL values and oral TRVs for the assessment of endrin intakes. Hence the current Australian TRV of 0.0002 mg/kg/day has been adopted for the derivation of soil HILs. No inhalation or dermal data is available, hence it is recommended that all intakes associated with contaminated soil be assessed on the basis of the oral TRV.

5.4.3         Recommendation
On the basis of the discussion above, the following toxicity reference values (TRVs) have been adopted for endrin in the derivation of HILs:

5.5              Calculated HILs
On the basis of the above, the following HILs have been derived for endrin (refer to Appendix B for equations used to calculate the HILs and Appendix C for calculations):
HIL Scenario            HIL (mg/kg)                      Percentage Contribution from Exposure Pathways
Ingestion of Soil/Dust  Ingestion of Home-grown Produce  Dermal Absorption of Soil/Dust                  Inhalation (dust)
Residential A           10                               43                                              --                 57  <1
Residential B           20                               16                                              --                 84  <1
Recreational C          20                               27                                              --                 73  <1
Commercial D            100                              12                                              --                 88  <1

-- Pathway not included in derivation of HIL

5.6              References
ATSDR 1996, Toxicological Profile for Endrin, available from: http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=617&tid=114.
DEH 2006, Stockholm Convention on Persistent Organic Pollutants, Australia's National Implementation Plan, Department of Environment and Heritage, Commonwealth of Australia, Canberra, Australia.
FSANZ 2003, The 20th Australian Total Diet Survey, a total diet survey of pesticide residues and contaminants, Food Standards Australia and New Zealand.
FSANZ 2011, The 23rd Australian Total Diet Study, Food Standards Australia and New Zealand.
IARC 1987, Summaries & Evaluations, Endrin, International Agency for Research on Cancer, Supplement 7, p.63.
JMPR 1970, 1970 Evaluations of Some Pesticides in Food, The Monographs, Endrin, JMPR, available from: http://www.inchem.org/documents/jmpr/jmpmono/v070pr13.htm.
NEPC 1999, Schedule B (7a), Guideline on Health-Based Investigation Levels, National Environment Protection (Assessment of Site Contamination) Measure, National Environment Protection Council, Australia.
NHMRC 2011, National water quality management strategy, Australian drinking water guidelines, National Health and Medical Research Council, Australia.
OCS 2012, ADI List, Acceptable Daily Intakes for Agricultural and Veterinary Chemicals, current to 31 March 2012, Australian Government, Department of Health and Ageing, Office of Chemical Safety (OCS), available from: http://www.health.gov.au/internet/main/publishing.nsf/content/E8F4D2F95D616584CA2573D700770C2A/$File/ADI-apr12.pdf.
RIVM 2001, Re-evaluation of human-toxicological Maximum Permissible Risk levels, National Institute of Public Health and the Environment, Bilthoven, Netherlands,