Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:6:p4
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 6 (pt 4/5)
Character Range: 2532034–2535596

LOAEL of 0.03 mg/kg/day associated with developmental immunological and neurological effects in rats (study also considered by WHO 2006), and an uncertainty factor of 300.
US EPA (IRIS 2012)  RfD = 0.0005 mg/kg/day      Oral RfD (last reviewed in 1987) based on a NOEL of 0.15 mg/kg/day associated with liver weight increases in a 2-year feeding study in rats and an uncertainty factor of 300. The US EPA has also derived non-threshold oral and inhalation values which are not presented here as they are not considered relevant.

Based on the available reviews, the oral TRVs derived are generally consistent with the value adopted in the ADWG (NHMRC 2011) considered to be suitable for the derivation of soil HILs. No inhalation or dermal data is available, hence it is recommended that all intakes associated with contaminated soil be assessed on the basis of the oral TRV.

6.4.3         Recommendation
On the basis of the discussion above, the following toxicity reference values (TRVs) have been adopted for heptachlor in the derivation of HILs:

6.5              Calculated HILs
On the basis of the above, the following HILs have been derived for heptachlor (refer to Appendix B for equations used to calculate the HILs and Appendix C for calculations):
HIL Scenario            HIL (mg/kg)                      Percentage Contribution from Exposure Pathways
Ingestion of Soil/Dust  Ingestion of Home-grown Produce  Dermal Absorption of Soil/Dust                  Inhalation (dust)
Residential A           6                                43                                              --                 57  <1
Residential B           10                               16                                              --                 84  <1
Recreational C          10                               27                                              --                 73  <1
Commercial D            50                               12                                              --                 88  <1

-- Pathway not included in derivation of HIL

6.6              References
ATSDR 2007, Toxicological Profile for Heptachlor and Heptachlor Epoxide, US Department of Health and Human Services, ATSDR, available from http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=746&tid=135.
Di Marco, P 1993, 'The Assessment and Management of Organochlorine Termiticides', presented in the proceedings of the Second National Workshop on the Health Risk Assessment and Management of Contaminated Sites, Contaminated Sites Monograph Series, No. 2.
FSANZ 2003, The 20th Australian Total Diet Survey, a total diet survey of pesticide residues and contaminants, Food Standards Australia andNew Zealand.
FSANZ 2011, The 23rd Australian Total Diet Study, Food Standards Australia and New Zealand.
IARC 2001, Summaries & Evaluations, Chlordane and Heptachlor, Vol 79, p. 411, International Agency for Research on Cancer.
JMPR (various), JMPR – Monographs and Evaluations for Heptachlor, available from http://www.inchem.org/pages/jmpr.html.
NEPC 1999, Schedule B (7a), Guideline on Health-Based Investigation Levels, National Environment Protection (Assessment of Site Contamination) Measure, National Environment Protection Council, Australia.
NHMRC 2011, National water quality management strategy, Australian drinking water guidelines, National Health and Medical Research Council, Australia.
OCS 2012, ADI List, Acceptable Daily Intakes for Agricultural and Veterinary Chemicals, current to 31 March 2012, Australian Government, Department of Health and Ageing, Office