Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:4:p4
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 4 (pt 4/5)
Character Range: 2509492–2513183

with liver effects in a dog study, and an uncertainty factor of 100.
US EPA (IRIS 2012)           RfD = 0.006 mg/kg/day       Oral RfD (last reviewed in 1994) is based on a NOAEL of 0.6/0.7 (M/F) mg/kg/day associated with kidney effects and aneurysms in a rat study, and an uncertainty factor of 100.

Based on the available reviews, a consistent oral TRV of 0.006 mg/kg/day is available and considered suitable for the derivation of soil HILs. No inhalation or dermal data is available hence it is recommended that all intakes associated with contaminated soil be assessed on the basis of the oral TRV.

4.4.3         Recommendation
On the basis of the discussion above, the following toxicity reference values (TRVs) have been adopted for endosulfan in the derivation of HILs:

4.5              Calculated HILs
On the basis of the above the following HILs have been derived for endosulfan (refer to Appendix B for equations used to calculate the HILs and Appendix C for calculations):
HIL Scenario            HIL (mg/kg)                      Percentage Contribution from Exposure Pathways
Ingestion of Soil/Dust  Ingestion of Home-grown Produce  Dermal Absorption of Soil/Dust                  Inhalation (dust)
Residential A           270                              43                                              --                 57  <1
Residential B           400                              16                                              --                 84  <1
Recreational C          340                              27                                              --                 73  <1
Commercial D            2000                             12                                              --                 88  <1

-- Pathway not included in derivation of HIL

4.6              References
APVMA 2005, The Reconsideration of Approval of Active Constituent Endosulfan, Registration of Products Containing Endosulfan and their Associated Labels, Final Review Report and Regulatory Decision Review Series 2, Australian Pesticide and Veterinary Medicines Authority Canberra, Australia.
ATSDR 2000, Toxicological Profile for Endosulfan, available on website at http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=609&tid=113.
FSANZ 2003, The 20th Australian Total Diet Survey, a total diet survey of pesticide residues and contaminants, Food Standards Australia and New Zealand.
FSANZ 2011, The 23rd Australian Total Diet Study, Food Standards Australia and New Zealand.
Marshall, I & Rutherford, S 2003, 'Health Investigation Level for Endosulfan in Soil', presented in the proceedings of the Fifth National Workshop on the Health Risk Assessment and Management of Contaminated Sites.
NEPC 1999, Schedule B (7a), Guideline on Health-Based Investigation Levels, National Environment Protection (Assessment of Site Contamination) Measure, National Environment Protection Council, Australia.
NHMRC 2011, National water quality management strategy, Australian drinking water guidelines, National Health and Medical Research Council, Australia.
NRA 1998, The NRA Review of Endosulfan, Volume 1, Existing Chemicals Review Program, National Registration Authority for Agricultural and Veterinary Chemicals, Commonwealth of Australia, ACT, Australia.
OCS 2012, ADI List, Acceptable Daily Intakes for Agricultural and Veterinary Chemicals, current to 31 March 2012, Australian Government, Department of Health and Ageing, Office of Chemical Safety (OCS), available from: http://www.health.gov.au/internet/main/publishing.nsf/content/E8F4D2F95D616584CA2573D700770C2A/$File/ADI-apr12.pdf.
US EPA 1995, Technical Guidance Manual, Assessing Dermal Exposure from Soil, US EPA Region 3,