Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:5:p8
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 5 (pt 8/9)
Character Range: 2162685–2166175

Calculated HILs
On the basis of the above (and using the assumptions presented in this document) an HIL A has been derived at 80 mg/kg, essentially the same (with consideration of uncertainties and accuracy of HIL calculations) as the existing HIL of 100 mg/kg. There is no new data available that suggests that the existing HIL is not adequately protective and therefore, given the level of uncertainty in the calculation of any HIL (including consideration of other oral TRVs available that are less conservative than the TRV adopted), the existing HIL A has been retained. HILs B, C and D have been calculated on the basis of the parameters referenced above.

On the basis of the above, the following HILs have been derived for Cr VI (refer to Appendix B for equations used to calculate the HILs and Appendix C for calculations):

HIL Scenario            HIL (mg/kg)                      Percentage Contribution from Exposure Pathways
Ingestion of Soil/Dust  Ingestion of Home-grown Produce  Dermal Absorption of Soil/Dust                  Inhalation (dust)
Residential A           100                              58                                              41                 --  1
Residential B           500                              97                                              --                 --  3
Recreational C          300                              99                                              --                 --  1
Commercial D            3600                             94                                              --                 --  6

-- Pathway not included in derivation of HIL

5.6              References
ATSDR 1997, Toxicological Profile for Chromium, Agency for Toxic Substances and Disease Registry.
ATSDR 2008, Draft Toxicological Profile for Chromium, Agency for Toxic Substances and Disease Registry. Available from http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=62&tid=17.
APVMA 2005, The Reconsideration of Registrations of Arsenic Timber Treatment Products (CCA and Arsenic Trioxide) and their Associated Labels, Report of Review Findings and Regulatory Outcomes, Summary Report, Review Series 3, Australian Pesticides &Veterinary Medicines Authority, Canberra, Australia.
Baars, AJ, Theelan, RMC, Janssen, PJCM, Hesse, JM, van Apeldoorn, ME, Meijerink, MCM, Verdam, L, Zeilmaker, MJ 2001, Re-evaluation of Human Toxicological Maximum Permissible Risk Levels, RIVM report 711701025, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
De Flora, S, Camoirana, A, Bagnasco, M et al. 1997, 'Estimates of the chromium(VI) reducing capacity in human body compartments as a mechanism for attenuating its potential toxicity and carcinogenicity', Carcinogenesis, vol. 18(3), pp. 531537.
DEFRA & EA 2002, Contaminants in Soil: Collation of Toxicological and Intake Data for Humans: Chromium, Department for Environment, Food and Rural Affairs and the Environment Agency, Bristol, UK.
FSANZ 2008, The 22nd Australian Total Diet Study, Food Standards Australia and New Zealand.
Guy, RH, Hostynek, JJ, Hinz, RS & Lorence, CR 1999, Metals and the Skin: Topical Effects and Systemic Absorption, Marcel Dekker, New York, USA.
Health Canada 2004, Contaminated Sites Program, Federal Contaminated Site Risk Assessment in Canada, Part I: Guidance of Human Health Preliminary Quantitative Risk Assessment (PQRA), September 2004.
IARC 2012, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans,