Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:3:p5
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 3 (pt 5/6)
Character Range: 2429727–2433512

PCP in the derivation of HILs:

3.5              Calculated HILs
On the basis of the above, the following HILs have been derived for PCP (refer to Appendix B for equations used to calculate the HILs and Appendix C for calculations):
HIL Scenario            HIL (mg/kg)                      Percentage Contribution from Exposure Pathways
Ingestion of Soil/Dust  Ingestion of Home-grown Produce  Dermal Absorption of Soil/Dust                  Inhalation (dust)
Residential A           100                              24                                              --                 76  <1
Residential B           130                              7                                               --                 93  <1
Recreational C          120                              13                                              --                 87  <1
Commercial D            660                              5                                               --                 95  <1

-- Pathway not included in derivation of HIL

3.6              References
ATSDR 2001, Toxicological profile for Pentachlorophenol, Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, Georgia, USA.
Cooper, GS & Jones, S 2008, 'Pentachlorophenol and cancer risk: focusing the lens on specific chlorophenols and contaminants'. Environmental Health Perspectives, vol. 116, pp. 10011008.
IARC 1991, - Summaries & Evaluations, Pentachlorophenol, vol. 53 (1991), p. 371, International Agency for Research on Cancer, Lyon, France.
McAllister, KA, Lee, H & Trevore, JT 1996, 'Microbial degradation of pentachlorophenol', Biodegradation, vol. , pp. 140.
Mecler, F 1996, Fifty-two week repeated dose chronic oral study of pentachlorophenol administered via capsule to dogs, Study conducted by TSI Mason Laboratories, Worcester, MA, TSI Report #ML-PTF-J31-95-94. Submitted to the Pentachlorophenol Task Force, c/o SRA International, Inc., Washington, DC. U.S. Environmental Protection Agency, Washington, DC; MRID 439827-01, unpublished report.
MfE 2011, Toxicological intake values for priority contaminants in soil, New Zealand Ministry for the Environment, Wellington, New Zealand.
NEPC 1999, Schedule B (7a), Guideline on Health-Based Investigation Levels, National Environment Protection (Assessment of Site Contamination) Measure, National Environment Protection Council, Australia.
NHMRC 2010, Cancer Risk Assessment Methodology:  A Review and Recommendations, September 2010, report prepared by NHMRC for NEPC, Adelaide, Australia.
NHMRC 2011, National water quality management strategy. Australian drinking water guidelines, National Health and Medical Research Council, Australia.
RIVM 2001, Re-evaluation of human-toxicological Maximum Permissible Risk levels, National Institute of Public Health and the Environment, Bilthoven, Netherlands, available from: http://www.rivm.nl/bibliotheek/rapporten/711701025.html.
US EPA (IRIS 2012), Data and information available from the Integrated Risk Information System, an online database, available from http://www.epa.gov/iris/.
US EPA 2004, Risk Assessment Guidance for Superfund, Volume I: Human Health Evaluation Manual (Part E, Supplemental Guidance for Dermal Risk Assessment), Final, EPA/540/R-99/005, OSWER 9285.7-02EP.
Wester, RC, Maibach, HI, Sedik, L, Melendres, J, Wade, M & Dizio, S 1993, 'Percutaneous Absorption of Pentachlorophenol from Soil', Fundamental & Applied Toxicology, vol. 20, No. 1, pp. 6871.
WHO 1987, Environmental Health Criteria No 71, Pentachlorophenol. World Health Organisation, Geneva.
WHO 2011, Guidelines for drinking-water quality, 4th edition, World Health Organisation, Geneva, available from http://www.who.int/water_sanitation_health/dwq/chemicals/en/index.html.