Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:2:p5
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 2 (pt 5/6)
Character Range: 2483509–2486964

for aldrin and dieldrin. It is not considered appropriate to quantify aldrin and dieldrin toxicity on the basis of a non-threshold approach.

All the key studies considered in the above reviews are dated (in the 1960s) and no new studies are available that suggest the evaluations provided and adopted in the Australian and WHO drinking water guidelines are not current. Hence the oral value adopted by NHMRC & NRMMC (2011) and WHO (2011) provide a suitable basis for the derivation of a soil HIL. No dermal or inhalation-specific studies or data are available. For the presence of aldrin and dieldrin in soil, it is considered appropriate to consider use of the available TRV for all pathways of exposures.

2.4.3         Recommendation
On the basis of the discussion above, the following toxicity reference values (TRVs) have been adopted for aldrin and dieldrin in the derivation of HILs:

2.5              Calculated HILs
On the basis of the above, the following HILs have been derived for aldrin and dieldrin (refer to Appendix B for equations used to calculate the HILs and Appendix C for calculations):
HIL Scenario            HIL (mg/kg)                      Percentage Contribution from Exposure Pathways
Ingestion of Soil/Dust  Ingestion of Home-grown Produce  Dermal Absorption of Soil/Dust                  Inhalation (dust)
Residential A           6                                43                                              --                 57  <1
Residential B           10                               16                                              --                 84  <1
Recreational C          10                               27                                              --                 73  <1
Commercial D            45                               12                                              --                 88  <1

-- Pathway not included in derivation of HIL

2.6              References
ATSDR 2002, Toxicological Profile for Aldrin/Dieldrin US Department of Health and Human Services, ATSDR, September 2002, available from http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=317&tid=56.
Di Marco, P 1993, 'The Assessment and Management of Organochlorine Termiticides', presented in the proceedings of the Second National Workshop on the Health Risk Assessment and Management of Contaminated Sites, Contaminated Sites Monograph Series, No. 2.
Feldmann, RJ & Maibach, HI 1974, 'Percutaneous penetration of some pesticides and herbicides in man', Toxicol. Appl. Pharmacol, vol. 28, pp. 126132.
Fitzhugh, OG & Nelson, AA 1963, Unpublished data from the US Food and Drug Administration, as cited in JMPR, 1967.
Fitzhugh, OG, Nelson, AA & Quaife, ML 1964, 'Chronic oral toxicity of aldrin and dieldrin in rats and dogs', Food Cosmet Toxicol, vol. 2, pp. 551562.
FSANZ 2003, The 20th Australian Total Diet Survey, A total diet survey of pesticide residues and contaminants, Food Standards Australia and New Zealand.
FSANZ 2011, The 23rd Australian Total Diet Study, Food Standards Australia and New Zealand.
IARC 1991, Summaries & Evaluations. DDT and Associated Compounds, vol. 53, (1991), p.179, International Agency for Research on Cancer.
NEPC 1999, Schedule B (7a), Guideline on Health-Based Investigation Levels, National Environment Protection (Assessment of Site Contamination) Measure, National Environment Protection Council, Australia.
NHMRC 2011, National water quality management strategy. Australian