Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:3:p4
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 3 (pt 4/5)
Character Range: 2496832–2500388

hepatic necrosis in a 104-week mouse study, and 300-fold uncertainty factor.
                    RfC = 0.0007 mg/m3              RfC based on hepatic effects in a subchronic rat inhalation study. The evaluation was last reviewed in 1998. In addition, US EPA has also derived an oral cancer slope factor and an inhalation unit risk (based on the oral evaluation). It is not considered appropriate to quantify chlordane toxicity on the basis of a non-threshold approach.

Based on the available data above, there is general agreement on the consideration of an oral TRV of 0.0005 mg/kg/day. Limited inhalation data is available, with the US EPA RfC essentially equivalent to the oral TRV; hence it is recommended that all intakes associated with contaminated soil be assessed on the basis of the oral TRV.

3.4.3         Recommendation
On the basis of the discussion above, the following toxicity reference values (TRVs) have been adopted for chlordane in the derivation of HILs:

3.5              Calculated HILs
On the basis of the above, the following HILs have been derived for chlordane (refer to Appendix B for equations used to calculate the HILs and Appendix C for calculations):
HIL Scenario            HIL (mg/kg)                      Percentage Contribution from Exposure Pathways
Ingestion of Soil/Dust  Ingestion of Home-grown Produce  Dermal Absorption of Soil/Dust                  Inhalation (dust)
Residential A           50                               65                                              --                 35  <1
Residential B           90                               32                                              --                 68  <1
Recreational C          70                               48                                              --                 52  <1
Commercial D            530                              25                                              --                 75  <1

-- Pathway not included in derivation of HIL

3.6              References
ATSDR 1994, Toxicological Profile for Chlordane, US Department of Health and Human Services, ATSDR, available from http://www.atsdr.cdc.gov/ToxProfiles/tp.asp?id=355&tid=62.
Di Marco, P 1993 'The Assessment and Management of Organochlorine Termiticides', presented in the proceedings of the Second National Workshop on the Health Risk Assessment and Management of Contaminated Sites, Contaminated Sites Monograph Series, No. 2, 1993.
EFSA 2007, 'Chlordane as undesirable substance in animal feed, Scientific Panel on contaminants in the Food Chain', The EFSA Journal, vol. 582, pp. 152, European Food Safety Authority, adopted 7 November 2007.
FSANZ 2003, The 20th Australian Total Diet Survey, A total diet survey of pesticide residues and contaminants, Food Standards Australia and New Zealand.
FSANZ 2011, The 23rd Australian Total Diet Study, Food Standards Australia and New Zealand.
IARC 2001, Summaries & Evaluations, Chlordane and Heptachlor, Vol. 79, p.411, International Agency for Research on Cancer.
NEPC 1999, Schedule B (7a), Guideline on Health-Based Investigation Levels, National Environment Protection (Assessment of Site Contamination) Measure, National Environment Protection Council, Australia.
NHMRC 2011, National water quality management strategy, Australian drinking water guidelines, National Health and Medical Research Council, Australia.
OCS 2012, ADI List, Acceptable Daily Intakes for Agricultural and Veterinary Chemicals, current to 31 March 2012, Australian Government, Department of Health and Ageing,