Document ID: chunk:federal_register_of_legislation:F2018L00556:reg:1:p1
Version: federal_register_of_legislation:F2018L00556
Segment Type: reg
Provision Reference: reg 1 (pt 1/2)
Character Range: 6055–10299

1               Definitions
In this instrument:
                                  adrenal neoplasm means a primary neoplasm, either benign (adenoma) or malignant (carcinoma), arising from the adrenal gland.
                                  Cushing syndrome—see subsection 7(2).
                               equivalent glucocorticoid therapy means a glucocorticoid in the following table, at the doses specified in the table, or a therapeutically equivalent dose of another glucocorticoid:

 Glucocorticoid      Minimum cumulative  Minimum average
                     dose (milligram)    rate (milligram/day)
 betamethasone       45                  1.5
 cortisone           1 875               62.5
 dexamethasone       55                  1.8
 methylprednisolone  300                 10
 paramethasone       150                 5
 prednisolone        375                 12.5
 prednisone          375                 12.5
 triamcinolone       300                 10

                               equivalent inhaled glucocorticoid means:
         (a)          2 000 micrograms of beclometasone;
         (b)          1 600 micrograms of ciclesonide;
         (c)          2 500 micrograms of fluticasone propionate;
         (d)          1 000 micrograms of fluticasone furoate;
         (e)          10 000 micrograms of triamcinolone; or
         (f)           a therapeutically equivalent dose of another inhaled glucocorticoid.
                               glucocorticoid therapy as specified means:
         (a)          applying a high or very high potency topical glucocorticoid to at least 30% of total skin surface area, daily, for at least six months; or
         (b)           inhaling at least 4 000 micrograms of budesonide, or equivalent inhaled glucocorticoid, daily, for at least six months; or
         (c)           taking:
            (i)             hydrocortisone, orally or by injection:
                (A)         to a cumulative dose of at least 1 500 milligrams; and
                (B)         at a minimum dose rate averaging 50 milligrams per day, or
            (ii)         equivalent glucocorticoid therapy, orally or by injection; or
         (d)           using a glucocorticoid concurrently with a drug, daily, for at least 4 weeks, where that drug can inhibit the activity of the metabolising enzyme cytochrome P450 3A4 by at least 30% (moderate to strong inhibition); or
         (e)                                       using a glucocorticoid concurrently with a drug from the specified list of drugs, daily, for at least four weeks; or
         (f)            using a clobetasol containing oral preparation, daily, for at least four weeks; or
         (g)          using glucocorticoid containing enemas, daily, for at least six months.
        Note: equivalent glucocorticoid therapy, equivalent inhaled glucocorticoid, high or very high potency topical glucocorticoid and specified list of drugs are also defined in the Schedule 1 – Dictionary.
                               high or very high potency topical glucocorticoid means:
         (a)          betamethasone dipropionate 0.05%;
         (b)          betamethasone valerate 0.1%;
         (c)          clobetasol proprionate 0.05%;
         (d)          diflucortolone valerate 0.1%;
         (e)          fluocinolone acetonide 0.025%;
         (f)           methylprednisolone 0.1%;
         (g)          mometasone 0.1%;
         (h)          triamcinolone acetonide 0.5%; or
         (i)            another topical glucocorticoid of equivalent potency.
                                  MRCA means the Military Rehabilitation and Compensation Act 2004.
                                  neuroendocrine neoplasm means a non-pituitary neoplasm that secretes polypeptides functionally equivalent to adrenocorticotrophic hormone (ACTH) or corticotropin-releasing hormone (CRH), and includes oat cell or small cell lung carcinoma, carcinoid tumour, islet cell tumour, tumours of the thymus, medullary carcinoma of the thyroid, and phaeochromocytoma.
                                  relevant service means:
         (a)          eligible war service (other than operational service) under the VEA;
         (b)          defence service