Document ID: chunk:federal_register_of_legislation:F2016L00424:front:0:p21
Version: federal_register_of_legislation:F2016L00424
Segment Type: other
Provision Reference: 
Character Range: 56863–59799

is recommended that the SDS take
a precautionary approach to health effects from exposure.

Exposure levels and health effects
The SDS should provide information on the dose, concentration or conditions of exposure that may cause adverse health effects. Where appropriate, doses should be linked to symptoms and effects, including the period of exposure likely to cause harm. For example, "10 ppm respiratory irritation, 250-300 ppm difficulty in breathing, 500 ppm unconsciousness leading to death after 30 minutes". Where exposure levels are not known, the SDS should take a precautionary approach to exposure levels or include links to potential health effects, if available.

Interactive effects
If known, information on interactions should be included in situations where:
    * symptoms are worsened by drinking alcohol, taking medication or smoking
    * pre-existing medical conditions – for example, asthma, high blood pressure or a predisposition to allergic reactions – may increase risk.

When specific chemical data is not available
Where there is insufficient data to classify a chemical, testing may be required. However, it may not always be possible to obtain information on the hazards of a chemical. In cases where data
on the specific hazardous chemical is not available, data on the chemical functional group, if appropriate, should be used. Where generic data is used or where data is not available, this should be stated clearly in the SDS.

Mixtures of chemicals
If a mixture has not been tested for its health effects as a whole, then information must be provided on each ingredient listed under Section 3 – Composition and Information on Ingredients.
Ingredients may interact with each other in the body resulting in different rates of absorption, metabolism and excretion. As a result, the toxic actions may be altered and the overall toxicity
of the mixture may be different from its ingredients.
This section should advise whether the concentration of each ingredient is sufficient to contribute to the overall health effects of the mixture. The information on toxic effects should be presented for each ingredient, except:
    * if the information is duplicated, in which case it is not necessary to list this more than once
      (for example, if two ingredients both cause vomiting and diarrhoea, the mixture should be described overall as causing vomiting and diarrhoea)
    * if it is unlikely that these effects will occur at the concentrations present (for example, when
      a mild irritant is diluted in a non-irritating solution, the overall mixture would be unlikely to
      cause irritation).
Predicting the interactions between ingredients is difficult where information on interactions is not available. However, assumptions should not be made. Instead, the SDS should list the health effects of each ingredient separately

Other information
It is recommended that other relevant information