Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:5:p3
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 5 (pt 3/7)
Character Range: 1017134–1021222

as carcinogens for the purposes of the risk assessment.
US Agency for Toxic Substances and Disease Registry (ATSDR) minimal risk levels and toxicological reviews                                                                                                                                                         ATSDR information is often based on the same sources as the Integrated Risk Information System (IRIS) database, but is independent of the US EPA. Its toxicological reviews are available on the web.
                                                                                                                                                                                                                                                                  ATSDR provides minimal risk levels (MRLs) for threshold effects which can be used in the same way as RfDs. MRLs can be accessed at http://www.atsdr.cdc.gov/mrls/index.html.
Other governmental sources of information on chemicals and risk assessment, e.g. NICNAS priority existing chemical reports, US EPA IRIS database, UK, Health Canada, Dutch and New Zealand guidance                                                               Useful for general toxicity information, and may provide support data such as bioavailability/ bioaccessibility, estimates for background concentrations, methods for considering groups of chemicals, mixtures, cumulative effects etc. Should be accompanied by robust justification.
                                                                                                                                                                                                                                                                  Toxicity criteria should only be derived from these when none are available from any source listed above.
Other sources of peer reviewed toxicity criteria including other US EPA sources such as the regional screening levels,  the PPRTV or HEAST tables on which the regional screening values are based or state-based US agencies such as California EPA, OEHHA etc.  Other sources of toxicity criteria suitable for use in risk assessment include US EPA's provisional peer reviewed toxicity values (PPRTV), California Environmental Protection Agency (Cal EPA) toxicity values, and the US EPA Superfund health effects assessment summary tables (HEAST).
Peer reviewed journals                                                                                                                                                                                                                                            In general single source papers from journals should not be used to derive toxicity information for contaminated land risk assessment. They do not normally comply with the requirement for having carried out extensive literature review, and budgets for site-specific risk assessment will not normally support such review. Where information sourced directly from journals is used, robust justification should be provided.

    5.1.2          Sources of physical and chemical data
Physical and chemical data are necessary inputs to the exposure modelling process, and also provide useful information on fate and transport of the contaminant. This data is generally experimentally derived, and some values may vary considerably between sources. The source of physical and chemical data should always be quoted in risk assessments, and the effects of uncertainty considered. As an aid to consistency and transparency in Australian risk assessment, the following sources, in order, are recommended for the selection of physical and chemical data. These sources are those used to derive the HILs  see Schedule B7.
    * ORNL (Oak Ridge National Laboratory) risk assessment information system, http://rais.ornl.gov/# (this database of physicochemical factors was completely reviewed in 2009 and so the outputs are now more consistent/reliable)
    * ATSDR (Agency for Toxic Substances and Disease Registry) toxicological profiles
    * Peer reviewed