Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:8:p2
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 8 (pt 2/7)
Character Range: 3040829–3043832

and differentiation; that is, genetic alterations incurred in the first damaged cells are acquired in subsequent cells after cell division within the same individual.
Cancer slope factor is the plausible upper-bound estimate of the probability of a carcinogen response per unit of intake of a chemical substance over a lifetime.
Carcinogen is a cancer-causing chemical substance/agent. A distinction may be made based on the presumed mode of action (MoA) – see genotoxic and non-genotoxic.
Chemical substance means any organic or inorganic substance, whether liquid, soil or gaseous.
Chemical of potential concern is a chemical substance that is potentially site-related and whose data is of sufficient quality to be judged as potentially causing an adverse health effect.
Chronic exposure is a continuous or intermittent long-term contact between a chemical substance and a target.
Clean-up level is a concentration of contaminant in soil or water derived for the purpose of providing an acceptable standard for remediation. May be risk-based or modified by considerations of feasibility, practicality, acceptability, timescale and cost.
Concentration is the amount of material or agent dissolved or contained in unit quantity in a given medium or system.
Conceptual site model (CSM) is the description of a site including the environmental setting, geological, hydrogeological and soil characteristics together with the nature and distribution of contaminants. Potentially exposed populations and exposure pathways are identified. Presentation is usually graphical or tabular with accompanying explanatory text.
Contact volume is a volume containing the mass of a chemical substance that contacts the exposure surface.
Contaminant is any chemical existing in the environment above background levels and representing, or potentially representing, an adverse health or environmental risk.
Contamination means the condition of land or water where any chemical substance or waste has been added as a direct or indirect result of human activity at above background level and represents, or potentially represents, an adverse health or environmental impact.
Critical effect is the adverse effect judged to be the most appropriate for determining the tolerable intake. It is usually the most sensitive adverse effect, that is, that with the lowest effect level, or sometimes a more severe effect, not necessarily having the lowest effect level.
Data quality objectives (DQOs) describe the establishment of the amount, nature and quality of data required to complete a specific risk assessment.
Default value is a pragmatic, fixed or standard value used in the absence of relevant data.
Dose is the stated quantity or concentration of a substance to which an organism, system or population is exposed over a continuous or intermittent duration of exposure. It is generally the total amount of a chemical administered to, taken up by, or absorbed by an organism, system, or population.
Doseresponse curve is a