Document ID: chunk:federal_register_of_legislation:F2013C00288:reg:3:p4
Version: federal_register_of_legislation:F2013C00288
Segment Type: reg
Provision Reference: reg 3 (pt 4/5)
Character Range: 2621635–2625435

studies identified for the determination of the point of departure differ between the OCS and WHO/US EPA evaluations. The subsequent application of uncertainty factors (with WHO/US EPA more conservative) also differs. Insufficient data is available to support any one evaluation, hence preference has been given to the Australian values adopted by OCS (2012), which have also been adopted in the derivation of the Australian Drinking Water Guidelines (NHMRC 2011). On this basis, the current Australian ADIs (as presented by OCS (2012)) have been adopted for the derivation of soil HILs.

No dermal or inhalation-specific studies or data are available. For the presence of MCPA, MCPB and mecoprop in soil (not during use) it is considered appropriate to consider use of the available ADI for all pathways of exposures.

3.4.3         Recommendation
On the basis of the discussion above, the following toxicity reference values (TRVs) have been adopted for MCPA, MCPB and mecoprop in the derivation of HILs:

3.5              Calculated HILs
On the basis of the above, the following HILs have been derived for MCPA, MCPB and mecoprop (as individual compounds) (refer to Appendix B for equations used to calculate the HILs and Appendix C for calculations):
HIL Scenario            HIL (mg/kg)                      Percentage Contribution from Exposure Pathways
Ingestion of Soil/Dust  Ingestion of Home-grown Produce  Dermal Absorption of Soil/Dust                  Inhalation (dust)
Residential A           600                              43                                              --                 57  <1
Residential B           900                              16                                              --                 84  <1
Recreational C          800                              27                                              --                 73  <1
Commercial D            5000                             12                                              --                 88  <1

-- Pathway not included in derivation of HIL

3.6              References
FSANZ 2003, The 20th Australian Total Diet Survey, a total diet survey of pesticide residues and contaminants, website: http://www.anzfa.gov.au/.
FSANZ 2011, The 23rd Australian Total Diet Study, Food Standards Australia and New Zealand.
HSDB (2010), Hazardous Substances Data Bank, online database available from: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB.
IARC 1987, Summaries and Evaluations, Chlorophenoxy herbicides, Supplement 7, (1987), p.256, International Agency for Research on Cancer.
NEPC 1999, Schedule B (7a), Guideline on Health-Based Investigation Levels, National Environment Protection (Assessment of Site Contamination) Measure, National Environment Protection Council, Australia.
NHMRC 2011, National water quality management strategy, Australian drinking water guidelines, National Health and Medical Research Council, Australia.
OCS 2012, ADI List, Acceptable Daily Intakes for Agricultural and Veterinary Chemicals, current to 31 March 2012, Australian Government, Department of Health and Ageing, Office of Chemical Safety (OCS), available from: http://www.health.gov.au/internet/main/publishing.nsf/content/E8F4D2F95D616584CA2573D700770C2A/$File/ADI-apr12.pdf.
US EPA 1995, Technical Guidance Manual, Assessing Dermal Exposure from Soil, US EPA Region 3, December 1995, available from: http://www.epa.gov/reg3hwmd/risk/human/info/solabsg2.htm.
US EPA (IRIS 2012), data and information available from the Integrated Risk Information System, an online database, available from http://www.epa.gov/iris/.
WHO 2011, Guidelines for drinking-water quality, 4th edition, World Health Organization, Geneva, available from http://www.who.int/water_sanitation_health/dwq/chemicals/en/index.html