mneb/bc5cdr · Datasets at Hugging Face

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Naloxone reverses the antihypertensive effect of clonidine. In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms / kg, was inhibited or reversed by nalozone, 0. 2 to 2 mg / kg. The hypotensive effect of 100 mg / kg alpha -...	{ "entities": { "chemical": [ { "text": "Naloxone", "start": 0, "end": 8 }, { "text": "clonidine", "start": 49, "end": 58 }, { "text": "clonidine", "start": 181, "end": 190 }, { "text": "naloz...	[]
Lidocaine - induced cardiac asystole. Intravenous administration of a single 50 - mg bolus of lidocaine in a 67 - year - old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pacemakers. The patient had no apparent associated conditions which might have predisposed him to ...	{ "entities": { "chemical": [ { "text": "Lidocaine", "start": 0, "end": 9 }, { "text": "lidocaine", "start": 94, "end": 103 }, { "text": "lidocaine", "start": 417, "end": 426 } ], "disease": [ ...	[]
Suxamethonium infusion rate and observed fasciculations. A dose - response study. Suxamethonium chloride (Sch) was administered i. v. to 36 adult males at six rates: 0. 25 mg s - 1 to 20 mg s - 1. The infusion was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when ...	{ "entities": { "chemical": [ { "text": "Suxamethonium", "start": 0, "end": 13 }, { "text": "Suxamethonium chloride", "start": 82, "end": 104 }, { "text": "Sch", "start": 106, "end": 109 }, { ...	[]
Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine). Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood - brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) ove...	{ "entities": { "chemical": [ { "text": "Galanthamine hydrobromide", "start": 0, "end": 25 }, { "text": "scopolamine", "start": 111, "end": 122 }, { "text": "Hyoscine", "start": 124, "end": 132 }, { ...	[]
Effects of uninephrectomy and high protein feeding on lithium - induced chronic renal failure in rats. Rats with lithium - induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal f...	{ "entities": { "chemical": [ { "text": "lithium", "start": 54, "end": 61 }, { "text": "lithium", "start": 113, "end": 120 }, { "text": "lithium", "start": 366, "end": 373 }, { "text": "lithiu...	[]
Treatment of Crohn' s disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin. Fusidic acid is an antibiotic with T - cell specific immunosuppressive effects similar to those of cyclosporin. Because of the need for the development of new treatments for Crohn' s disease, a pilot...	{ "entities": { "chemical": [ { "text": "fusidic acid", "start": 35, "end": 47 }, { "text": "cyclosporin", "start": 108, "end": 119 }, { "text": "cyclosporin", "start": 220, "end": 231 }, { "t...	[]
Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers. The electrocardiograms (ECG) of 99 cocaine - abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the cocaine abusers and none of the controls had ECG evidence of significant myocardial in...	{ "entities": { "chemical": [ { "text": "cocaine", "start": 83, "end": 90 }, { "text": "cocaine", "start": 135, "end": 142 }, { "text": "cocaine", "start": 234, "end": 241 } ], "disease": [ { ...	[]
Sulpiride - induced tardive dystonia. Sulpiride is a selective D2 - receptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyramidal side effects, sulpiride - induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a 37 - year ...	{ "entities": { "chemical": [ { "text": "Sulpiride", "start": 0, "end": 9 }, { "text": "Sulpiride", "start": 38, "end": 47 }, { "text": "antidepressant", "start": 111, "end": 125 }, { "text": ...	[]
Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine. During an 18 - month period of study 41 hemodialyzed patients receiving desferrioxamine (10 - 40 mg / kg BW / 3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms o...	{ "entities": { "chemical": [ { "text": "desferrioxamine", "start": 64, "end": 79 }, { "text": "desferrioxamine", "start": 153, "end": 168 }, { "text": "Desferrioxamine", "start": 779, "end": 794 }, {...	[]
Myasthenia gravis presenting as weakness after magnesium administration. We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentration was 3. 0 mEq / L, which is usually well tolerated. ...	{ "entities": { "chemical": [ { "text": "magnesium", "start": 47, "end": 56 }, { "text": "magnesium", "start": 192, "end": 201 }, { "text": "magnesium", "start": 245, "end": 254 }, { "text": "...	[]
Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study / short communication. Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in ...	{ "entities": { "chemical": [ { "text": "Chloroacetaldehyde", "start": 0, "end": 18 }, { "text": "cyclophosphamide", "start": 77, "end": 93 }, { "text": "ifosfamide", "start": 97, "end": 107 }, { ...	[]
Source of pain and primitive dysfunction in migraine: an identical site? Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by nitroglycerin in seven out of 10...	{ "entities": { "chemical": [ { "text": "nitroglycerin", "start": 156, "end": 169 }, { "text": "nitroglycerin", "start": 288, "end": 301 }, { "text": "nitroglycerin", "start": 461, "end": 474 }, { ...	[]
Clotiazepam - induced acute hepatitis. We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recovery. The administration of several benz...	{ "entities": { "chemical": [ { "text": "Clotiazepam", "start": 0, "end": 11 }, { "text": "clotiazepam", "start": 187, "end": 198 }, { "text": "thienodiazepine", "start": 202, "end": 217 }, { ...	[]
Arterial hypertension as a complication of prolonged ketoconazole treatment. Two of 14 patients with Cushing' s syndrome treated on a long - term basis with ketoconazole developed sustained hypertension. In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet c...	{ "entities": { "chemical": [ { "text": "ketoconazole", "start": 53, "end": 65 }, { "text": "ketoconazole", "start": 157, "end": 169 }, { "text": "cortisol", "start": 249, "end": 257 }, { "tex...	[]
Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat. Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal in...	{ "entities": { "chemical": [ { "text": "angiotensin", "start": 27, "end": 38 }, { "text": "Captopril", "start": 58, "end": 67 }, { "text": "tranexamic acid", "start": 250, "end": 265 }, { "te...	[]
A randomized comparison of labetalol and nitroprusside for induced hypotension. In a randomized study, labetalol - induced hypotension and nitroprusside - induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic ...	{ "entities": { "chemical": [ { "text": "labetalol", "start": 27, "end": 36 }, { "text": "nitroprusside", "start": 41, "end": 54 }, { "text": "labetalol", "start": 103, "end": 112 }, { "text":...	[]
Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations. Folate depletion has often been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies. A rat model was developed ...	{ "entities": { "chemical": [ { "text": "carbamazepine", "start": 8, "end": 21 }, { "text": "folate", "start": 96, "end": 102 }, { "text": "Folate", "start": 119, "end": 125 }, { "text": "Carb...	[]
Inhibition of sympathoadrenal activity by atrial natriuretic factor in dogs. In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq / kg / day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15 - minute i. v. infusions of human alpha - atrial n...	{ "entities": { "chemical": [ { "text": "sodium", "start": 132, "end": 138 }, { "text": "norepinephrine", "start": 229, "end": 243 }, { "text": "epinephrine", "start": 248, "end": 259 }, { "te...	[]
Death from chemotherapy in gestational trophoblastic disease. Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high - risk stage of choriocarcinoma. Based on this principle a 27 - year old woman, classified as being in the high - risk group (Goldstein and Berkowitz score: 11...	{ "entities": { "chemical": [ { "text": "Etoposide", "start": 405, "end": 414 }, { "text": "Methotrexate", "start": 424, "end": 436 }, { "text": "Cyclophosphamide", "start": 438, "end": 454 }, { ...	[]
Sexual dysfunction among patients with arthritis. The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair - matched to controls. Assessments of marital happiness and depressed mood were also made us...	{ "entities": { "chemical": [ { "text": "methotrexate", "start": 648, "end": 660 } ], "disease": [ { "text": "Sexual dysfunction", "start": 0, "end": 18 }, { "text": "arthritis", "start": 39, "end": 48 ...	[]
Does paracetamol cause urothelial cancer or renal papillary necrosis? The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The r...	{ "entities": { "chemical": [ { "text": "paracetamol", "start": 5, "end": 16 }, { "text": "phenacetin", "start": 205, "end": 215 }, { "text": "paracetamol", "start": 219, "end": 230 }, { "text...	[]
Dapsone - associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait. A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg / day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had in...	{ "entities": { "chemical": [ { "text": "Dapsone", "start": 0, "end": 7 }, { "text": "dapsone", "start": 217, "end": 224 }, { "text": "glutathione", "start": 378, "end": 389 }, { "text": "GSH"...	[]
Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. A 47 - year - old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular fun...	{ "entities": { "chemical": [ { "text": "metoprolol", "start": 98, "end": 108 }, { "text": "propafenone", "start": 110, "end": 121 }, { "text": "diltiazem", "start": 123, "end": 132 }, { "text...	[]
Triazolam - induced brief episodes of secondary mania in a depressed patient. Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The p...	{ "entities": { "chemical": [ { "text": "Triazolam", "start": 0, "end": 9 }, { "text": "triazolam", "start": 93, "end": 102 }, { "text": "triazolam", "start": 304, "end": 313 }, { "text": "tri...	[]
On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats. The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline - pretreated controls given a test dose of morphine (20 mg / kg i. p.) showed a pronounced rigidity recorded as ...	{ "entities": { "chemical": [ { "text": "morphine", "start": 87, "end": 95 }, { "text": "morphine", "start": 171, "end": 179 }, { "text": "morphine", "start": 251, "end": 259 }, { "text": "mor...	[]
Compression neuropathy of the radial nerve due to pentazocine - induced fibrous myopathy. Fibrous myopathy is a common, well - known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine - induced myopathy has not previously been reported. In a 37 ...	{ "entities": { "chemical": [ { "text": "pentazocine", "start": 50, "end": 61 }, { "text": "pentazocine", "start": 157, "end": 168 }, { "text": "pentazocine", "start": 247, "end": 258 }, { "te...	[]
Recurrent reversible acute renal failure from amphotericin. A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days sugg...	{ "entities": { "chemical": [ { "text": "amphotericin", "start": 46, "end": 58 }, { "text": "amphotericin B", "start": 203, "end": 217 }, { "text": "amphotericin", "start": 405, "end": 417 } ], "dis...	[]
Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy. A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumoniti...	{ "entities": { "chemical": [ { "text": "amiodarone", "start": 72, "end": 82 }, { "text": "amiodarone", "start": 167, "end": 177 }, { "text": "amiodarone", "start": 462, "end": 472 }, { "text"...	[]
Indomethacin - induced renal insufficiency: recurrence on rechallenge. We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re - exposure to a sin...	{ "entities": { "chemical": [ { "text": "Indomethacin", "start": 0, "end": 12 }, { "text": "indomethacin", "start": 207, "end": 219 }, { "text": "indomethacin", "start": 332, "end": 344 }, { "...	[]
Comparison of the subjective effects and plasma concentrations following oral and i. m. administration of flunitrazepam in volunteers. Flunitrazepam 0. 5, 1. 0 or 2. 0 mg was given by the oral or i. m. routes to groups of volunteers and its effects compared. Plasma concentrations of the drug were estimated by gas - liq...	{ "entities": { "chemical": [ { "text": "flunitrazepam", "start": 106, "end": 119 }, { "text": "Flunitrazepam", "start": 135, "end": 148 }, { "text": "flunitrazepam", "start": 753, "end": 766 } ], "...	[]
Changes in heart size during long - term timolol treatment after myocardial infarction. The effect of long - term timolol treatment on heart size after myocardial infarction was evaluated by X - ray in a double - blind study including 241 patients (placebo 126, timolol 115). The follow - up period was 12 months. The ti...	{ "entities": { "chemical": [ { "text": "timolol", "start": 41, "end": 48 }, { "text": "timolol", "start": 114, "end": 121 }, { "text": "timolol", "start": 262, "end": 269 }, { "text": "timolo...	[]
Vitamin D3 toxicity in dairy cows. Large parenteral doses of vitamin D3 (15 to 17. 5 x 10 (6) IU vitamin D3) were associated with prolonged hypercalcemia, hyperphosphatemia, and large increases of vitamin D3 and its metabolites in the blood plasma of nonlactating nonpregnant and pregnant Jersey cows. Calcium concentrat...	{ "entities": { "chemical": [ { "text": "Vitamin D3", "start": 0, "end": 10 }, { "text": "vitamin D3", "start": 61, "end": 71 }, { "text": "vitamin D3", "start": 97, "end": 107 }, { "text": "v...	[]
Diseases of peripheral nerves as seen in the Nigerian African. The anatomical and aetiological diagnoses of peripheral nerve disease excluding its primary benign and malignant disorders, as seen in 358 Nigerians are presented. There is a male preponderance and the peak incidence is in the fourth decade. Sensori - motor...	{ "entities": { "chemical": [ { "text": "thiamine", "start": 553, "end": 561 }, { "text": "riboflavin", "start": 566, "end": 576 }, { "text": "Isoniazid", "start": 724, "end": 733 } ], "disease": [ ...	[]
A double - blind study of the efficacy and safety of dothiepin hydrochloride in the treatment of major depressive disorder. In a 6 - week double - blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally e...	{ "entities": { "chemical": [ { "text": "dothiepin hydrochloride", "start": 53, "end": 76 }, { "text": "dothiepin", "start": 179, "end": 188 }, { "text": "amitriptyline", "start": 193, "end": 206 }, {...	[]
Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia. The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg / day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg / day for 2 weeks) on psychological performance of p...	{ "entities": { "chemical": [ { "text": "diazepam", "start": 22, "end": 30 }, { "text": "propranolol", "start": 35, "end": 46 }, { "text": "diazepam", "start": 125, "end": 133 }, { "text": "pr...	[]
Effect of aspirin on N - [4 - (5 - nitro - 2 - furyl) - 2 - thiazolyl] - formamide - induced epithelial proliferation in the urinary bladder and forestomach of the rat. The co - administration of aspirin with N - [4 - (5 - nitro - 2 - furyl) - 2 - thiazolyl] - formamide (FANFT) to rats resulted in a reduced incidence o...	{ "entities": { "chemical": [ { "text": "aspirin", "start": 10, "end": 17 }, { "text": "N - [4 - (5 - nitro - 2 - furyl) - 2 - thiazolyl] - formamide", "start": 21, "end": 82 }, { "text": "aspirin", "start": 196, ...	[]
Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy? The effect of nitroglycerin on heart rate and systolic blood pressure was compared in 5 normal subjects, 12 diabetic subjects without autonomic neuropathy, and 5 diabetic subjects with autonomic neuropathy. The magnitude and time cou...	{ "entities": { "chemical": [ { "text": "nitroglycerin", "start": 39, "end": 52 }, { "text": "nitroglycerin", "start": 101, "end": 114 }, { "text": "nitroglycerin", "start": 404, "end": 417 } ], "di...	[]
Characterization of estrogen - induced adenohypophyseal tumors in the Fischer 344 rat. Pituitary tumors were induced in F344 female rats by chronic treatment with diethylstilbestrol (DES, 8 - 10 mg) implanted subcutaneously in silastic capsules. Over a range of 1 - 150 days of DES treatment, pairs of control and DES - ...	{ "entities": { "chemical": [ { "text": "estrogen", "start": 20, "end": 28 }, { "text": "diethylstilbestrol", "start": 163, "end": 181 }, { "text": "DES", "start": 183, "end": 186 }, { "text":...	[]
Triamterene nephrolithiasis complicating dyazide therapy. A case of triamterene nephrolithiasis is reported in a man after 4 years of hydrochlorothiazide - triamterene therapy for hypertension. The stone passed spontaneously and was found to contain a triamterene metabolite admixed with uric acid salts. Factors affecti...	{ "entities": { "chemical": [ { "text": "Triamterene", "start": 0, "end": 11 }, { "text": "dyazide", "start": 41, "end": 48 }, { "text": "triamterene", "start": 68, "end": 79 }, { "text": "hyd...	[]
Metabolic involvement in adriamycin cardiotoxicity. The cardiotoxic effects of adriamycin were studied in mammalian myocardial cells in culture as a model system. Adriamycin inhibited cell growth and the rhythmic contractions characteristic of myocardial cells in culture. A possible involvement of energy metabolism was...	{ "entities": { "chemical": [ { "text": "adriamycin", "start": 25, "end": 35 }, { "text": "adriamycin", "start": 79, "end": 89 }, { "text": "Adriamycin", "start": 163, "end": 173 }, { "text": ...	[]
Age - dependent sensitivity of the rat to neurotoxic effects of streptomycin. Streptomycin sulfate (300 mg / kg s. c.) was injected for various periods into preweanling rats and for 3 weeks into weanling rats. Beginning at 8 days of age, body movement and hearing were examined for 6 and up to 17 weeks, respectively. Ab...	{ "entities": { "chemical": [ { "text": "streptomycin", "start": 64, "end": 76 }, { "text": "Streptomycin", "start": 78, "end": 90 }, { "text": "streptomycin", "start": 595, "end": 607 } ], "disease...	[]
Crescentic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis. This case study reveals an unusual finding of rapidly proliferative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiable causes for developing this disease. This p...	{ "entities": { "chemical": [ { "text": "rifampin", "start": 70, "end": 78 }, { "text": "rifampin", "start": 239, "end": 247 }, { "text": "rifampin", "start": 361, "end": 369 }, { "text": "iso...	[]
Time course of lipid peroxidation in puromycin aminonucleoside - induced nephropathy. Reactive oxygen species have been implicated in the pathogenesis of acute puromycin aminonucleoside (PAN) - induced nephropathy, with antioxidants significantly reducing the proteinuria. The temporal relationship between lipid peroxid...	{ "entities": { "chemical": [ { "text": "puromycin aminonucleoside", "start": 37, "end": 62 }, { "text": "oxygen", "start": 95, "end": 101 }, { "text": "puromycin aminonucleoside", "start": 160, "end": 185 ...	[]
Clomipramine - induced sleep disturbance does not impair its prolactin - releasing action. The present study was undertaken to examine the role of sleep disturbance, induced by clomipramine administration, on the secretory rate of prolactin (PRL) in addition to the direct drug effect. Two groups of supine subjects were...	{ "entities": { "chemical": [ { "text": "Clomipramine", "start": 0, "end": 12 }, { "text": "clomipramine", "start": 177, "end": 189 }, { "text": "clomipramine", "start": 503, "end": 515 }, { "...	[]
Angioedema following the intravenous administration of metoprolol. A 72 - year - old woman was admitted to the hospital with " flash " pulmonary edema, preceded by chest pain, requiring intubation. Her medical history included coronary artery disease with previous myocardial infarctions, hypertension, and diabetes mell...	{ "entities": { "chemical": [ { "text": "metoprolol", "start": 55, "end": 65 }, { "text": "lisinopril", "start": 363, "end": 373 }, { "text": "angiotensin", "start": 432, "end": 443 }, { "text...	[]
Effect of coniine on the developing chick embryo. Coniine, an alkaloid from Conium maculatum (poison hemlock), has been shown to be teratogenic in livestock. The major teratogenic outcome is arthrogryposis, presumably due to nicotinic receptor blockade. However, coniine has failed to produce arthrogryposis in rats or m...	{ "entities": { "chemical": [ { "text": "coniine", "start": 10, "end": 17 }, { "text": "Coniine", "start": 50, "end": 57 }, { "text": "coniine", "start": 263, "end": 270 }, { "text": "coniine"...	[]

Naloxone reverses the antihypertensive effect of clonidine. In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms / kg, was inhibited or reversed by nalozone, 0. 2 to 2 mg / kg. The hypotensive effect of 100 mg / kg alpha -...

{ "entities": { "chemical": [ { "text": "Naloxone", "start": 0, "end": 8 }, { "text": "clonidine", "start": 49, "end": 58 }, { "text": "clonidine", "start": 181, "end": 190 }, { "text": "naloz...

[]

Lidocaine - induced cardiac asystole. Intravenous administration of a single 50 - mg bolus of lidocaine in a 67 - year - old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pacemakers. The patient had no apparent associated conditions which might have predisposed him to ...

{ "entities": { "chemical": [ { "text": "Lidocaine", "start": 0, "end": 9 }, { "text": "lidocaine", "start": 94, "end": 103 }, { "text": "lidocaine", "start": 417, "end": 426 } ], "disease": [ ...

[]

Suxamethonium infusion rate and observed fasciculations. A dose - response study. Suxamethonium chloride (Sch) was administered i. v. to 36 adult males at six rates: 0. 25 mg s - 1 to 20 mg s - 1. The infusion was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when ...

{ "entities": { "chemical": [ { "text": "Suxamethonium", "start": 0, "end": 13 }, { "text": "Suxamethonium chloride", "start": 82, "end": 104 }, { "text": "Sch", "start": 106, "end": 109 }, { ...

[]

Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine). Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood - brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) ove...

{ "entities": { "chemical": [ { "text": "Galanthamine hydrobromide", "start": 0, "end": 25 }, { "text": "scopolamine", "start": 111, "end": 122 }, { "text": "Hyoscine", "start": 124, "end": 132 }, { ...

[]

Effects of uninephrectomy and high protein feeding on lithium - induced chronic renal failure in rats. Rats with lithium - induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal f...

{ "entities": { "chemical": [ { "text": "lithium", "start": 54, "end": 61 }, { "text": "lithium", "start": 113, "end": 120 }, { "text": "lithium", "start": 366, "end": 373 }, { "text": "lithiu...

[]

Treatment of Crohn' s disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin. Fusidic acid is an antibiotic with T - cell specific immunosuppressive effects similar to those of cyclosporin. Because of the need for the development of new treatments for Crohn' s disease, a pilot...

{ "entities": { "chemical": [ { "text": "fusidic acid", "start": 35, "end": 47 }, { "text": "cyclosporin", "start": 108, "end": 119 }, { "text": "cyclosporin", "start": 220, "end": 231 }, { "t...

[]

Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers. The electrocardiograms (ECG) of 99 cocaine - abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the cocaine abusers and none of the controls had ECG evidence of significant myocardial in...

{ "entities": { "chemical": [ { "text": "cocaine", "start": 83, "end": 90 }, { "text": "cocaine", "start": 135, "end": 142 }, { "text": "cocaine", "start": 234, "end": 241 } ], "disease": [ { ...

[]

Sulpiride - induced tardive dystonia. Sulpiride is a selective D2 - receptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyramidal side effects, sulpiride - induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a 37 - year ...

{ "entities": { "chemical": [ { "text": "Sulpiride", "start": 0, "end": 9 }, { "text": "Sulpiride", "start": 38, "end": 47 }, { "text": "antidepressant", "start": 111, "end": 125 }, { "text": ...

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Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine. During an 18 - month period of study 41 hemodialyzed patients receiving desferrioxamine (10 - 40 mg / kg BW / 3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms o...

{ "entities": { "chemical": [ { "text": "desferrioxamine", "start": 64, "end": 79 }, { "text": "desferrioxamine", "start": 153, "end": 168 }, { "text": "Desferrioxamine", "start": 779, "end": 794 }, {...

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Myasthenia gravis presenting as weakness after magnesium administration. We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentration was 3. 0 mEq / L, which is usually well tolerated. ...

{ "entities": { "chemical": [ { "text": "magnesium", "start": 47, "end": 56 }, { "text": "magnesium", "start": 192, "end": 201 }, { "text": "magnesium", "start": 245, "end": 254 }, { "text": "...

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Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study / short communication. Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in ...

{ "entities": { "chemical": [ { "text": "Chloroacetaldehyde", "start": 0, "end": 18 }, { "text": "cyclophosphamide", "start": 77, "end": 93 }, { "text": "ifosfamide", "start": 97, "end": 107 }, { ...

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Source of pain and primitive dysfunction in migraine: an identical site? Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by nitroglycerin in seven out of 10...

{ "entities": { "chemical": [ { "text": "nitroglycerin", "start": 156, "end": 169 }, { "text": "nitroglycerin", "start": 288, "end": 301 }, { "text": "nitroglycerin", "start": 461, "end": 474 }, { ...

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Clotiazepam - induced acute hepatitis. We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recovery. The administration of several benz...

{ "entities": { "chemical": [ { "text": "Clotiazepam", "start": 0, "end": 11 }, { "text": "clotiazepam", "start": 187, "end": 198 }, { "text": "thienodiazepine", "start": 202, "end": 217 }, { ...

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Arterial hypertension as a complication of prolonged ketoconazole treatment. Two of 14 patients with Cushing' s syndrome treated on a long - term basis with ketoconazole developed sustained hypertension. In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet c...

{ "entities": { "chemical": [ { "text": "ketoconazole", "start": 53, "end": 65 }, { "text": "ketoconazole", "start": 157, "end": 169 }, { "text": "cortisol", "start": 249, "end": 257 }, { "tex...

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Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat. Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal in...

{ "entities": { "chemical": [ { "text": "angiotensin", "start": 27, "end": 38 }, { "text": "Captopril", "start": 58, "end": 67 }, { "text": "tranexamic acid", "start": 250, "end": 265 }, { "te...

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A randomized comparison of labetalol and nitroprusside for induced hypotension. In a randomized study, labetalol - induced hypotension and nitroprusside - induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic ...

{ "entities": { "chemical": [ { "text": "labetalol", "start": 27, "end": 36 }, { "text": "nitroprusside", "start": 41, "end": 54 }, { "text": "labetalol", "start": 103, "end": 112 }, { "text":...

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Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations. Folate depletion has often been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies. A rat model was developed ...

{ "entities": { "chemical": [ { "text": "carbamazepine", "start": 8, "end": 21 }, { "text": "folate", "start": 96, "end": 102 }, { "text": "Folate", "start": 119, "end": 125 }, { "text": "Carb...

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Inhibition of sympathoadrenal activity by atrial natriuretic factor in dogs. In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq / kg / day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15 - minute i. v. infusions of human alpha - atrial n...

{ "entities": { "chemical": [ { "text": "sodium", "start": 132, "end": 138 }, { "text": "norepinephrine", "start": 229, "end": 243 }, { "text": "epinephrine", "start": 248, "end": 259 }, { "te...

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Death from chemotherapy in gestational trophoblastic disease. Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high - risk stage of choriocarcinoma. Based on this principle a 27 - year old woman, classified as being in the high - risk group (Goldstein and Berkowitz score: 11...

{ "entities": { "chemical": [ { "text": "Etoposide", "start": 405, "end": 414 }, { "text": "Methotrexate", "start": 424, "end": 436 }, { "text": "Cyclophosphamide", "start": 438, "end": 454 }, { ...

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Sexual dysfunction among patients with arthritis. The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair - matched to controls. Assessments of marital happiness and depressed mood were also made us...

{ "entities": { "chemical": [ { "text": "methotrexate", "start": 648, "end": 660 } ], "disease": [ { "text": "Sexual dysfunction", "start": 0, "end": 18 }, { "text": "arthritis", "start": 39, "end": 48 ...

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Does paracetamol cause urothelial cancer or renal papillary necrosis? The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The r...

{ "entities": { "chemical": [ { "text": "paracetamol", "start": 5, "end": 16 }, { "text": "phenacetin", "start": 205, "end": 215 }, { "text": "paracetamol", "start": 219, "end": 230 }, { "text...

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Dapsone - associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait. A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg / day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had in...

{ "entities": { "chemical": [ { "text": "Dapsone", "start": 0, "end": 7 }, { "text": "dapsone", "start": 217, "end": 224 }, { "text": "glutathione", "start": 378, "end": 389 }, { "text": "GSH"...

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Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. A 47 - year - old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular fun...

{ "entities": { "chemical": [ { "text": "metoprolol", "start": 98, "end": 108 }, { "text": "propafenone", "start": 110, "end": 121 }, { "text": "diltiazem", "start": 123, "end": 132 }, { "text...

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Triazolam - induced brief episodes of secondary mania in a depressed patient. Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The p...

{ "entities": { "chemical": [ { "text": "Triazolam", "start": 0, "end": 9 }, { "text": "triazolam", "start": 93, "end": 102 }, { "text": "triazolam", "start": 304, "end": 313 }, { "text": "tri...

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On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats. The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline - pretreated controls given a test dose of morphine (20 mg / kg i. p.) showed a pronounced rigidity recorded as ...

{ "entities": { "chemical": [ { "text": "morphine", "start": 87, "end": 95 }, { "text": "morphine", "start": 171, "end": 179 }, { "text": "morphine", "start": 251, "end": 259 }, { "text": "mor...

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Compression neuropathy of the radial nerve due to pentazocine - induced fibrous myopathy. Fibrous myopathy is a common, well - known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine - induced myopathy has not previously been reported. In a 37 ...

{ "entities": { "chemical": [ { "text": "pentazocine", "start": 50, "end": 61 }, { "text": "pentazocine", "start": 157, "end": 168 }, { "text": "pentazocine", "start": 247, "end": 258 }, { "te...

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Recurrent reversible acute renal failure from amphotericin. A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days sugg...

{ "entities": { "chemical": [ { "text": "amphotericin", "start": 46, "end": 58 }, { "text": "amphotericin B", "start": 203, "end": 217 }, { "text": "amphotericin", "start": 405, "end": 417 } ], "dis...

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Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy. A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumoniti...

{ "entities": { "chemical": [ { "text": "amiodarone", "start": 72, "end": 82 }, { "text": "amiodarone", "start": 167, "end": 177 }, { "text": "amiodarone", "start": 462, "end": 472 }, { "text"...

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Indomethacin - induced renal insufficiency: recurrence on rechallenge. We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re - exposure to a sin...

{ "entities": { "chemical": [ { "text": "Indomethacin", "start": 0, "end": 12 }, { "text": "indomethacin", "start": 207, "end": 219 }, { "text": "indomethacin", "start": 332, "end": 344 }, { "...

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Comparison of the subjective effects and plasma concentrations following oral and i. m. administration of flunitrazepam in volunteers. Flunitrazepam 0. 5, 1. 0 or 2. 0 mg was given by the oral or i. m. routes to groups of volunteers and its effects compared. Plasma concentrations of the drug were estimated by gas - liq...

{ "entities": { "chemical": [ { "text": "flunitrazepam", "start": 106, "end": 119 }, { "text": "Flunitrazepam", "start": 135, "end": 148 }, { "text": "flunitrazepam", "start": 753, "end": 766 } ], "...

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Changes in heart size during long - term timolol treatment after myocardial infarction. The effect of long - term timolol treatment on heart size after myocardial infarction was evaluated by X - ray in a double - blind study including 241 patients (placebo 126, timolol 115). The follow - up period was 12 months. The ti...

{ "entities": { "chemical": [ { "text": "timolol", "start": 41, "end": 48 }, { "text": "timolol", "start": 114, "end": 121 }, { "text": "timolol", "start": 262, "end": 269 }, { "text": "timolo...

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Vitamin D3 toxicity in dairy cows. Large parenteral doses of vitamin D3 (15 to 17. 5 x 10 (6) IU vitamin D3) were associated with prolonged hypercalcemia, hyperphosphatemia, and large increases of vitamin D3 and its metabolites in the blood plasma of nonlactating nonpregnant and pregnant Jersey cows. Calcium concentrat...

{ "entities": { "chemical": [ { "text": "Vitamin D3", "start": 0, "end": 10 }, { "text": "vitamin D3", "start": 61, "end": 71 }, { "text": "vitamin D3", "start": 97, "end": 107 }, { "text": "v...

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Diseases of peripheral nerves as seen in the Nigerian African. The anatomical and aetiological diagnoses of peripheral nerve disease excluding its primary benign and malignant disorders, as seen in 358 Nigerians are presented. There is a male preponderance and the peak incidence is in the fourth decade. Sensori - motor...

{ "entities": { "chemical": [ { "text": "thiamine", "start": 553, "end": 561 }, { "text": "riboflavin", "start": 566, "end": 576 }, { "text": "Isoniazid", "start": 724, "end": 733 } ], "disease": [ ...

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A double - blind study of the efficacy and safety of dothiepin hydrochloride in the treatment of major depressive disorder. In a 6 - week double - blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally e...

{ "entities": { "chemical": [ { "text": "dothiepin hydrochloride", "start": 53, "end": 76 }, { "text": "dothiepin", "start": 179, "end": 188 }, { "text": "amitriptyline", "start": 193, "end": 206 }, {...

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Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia. The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg / day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg / day for 2 weeks) on psychological performance of p...

{ "entities": { "chemical": [ { "text": "diazepam", "start": 22, "end": 30 }, { "text": "propranolol", "start": 35, "end": 46 }, { "text": "diazepam", "start": 125, "end": 133 }, { "text": "pr...

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Effect of aspirin on N - [4 - (5 - nitro - 2 - furyl) - 2 - thiazolyl] - formamide - induced epithelial proliferation in the urinary bladder and forestomach of the rat. The co - administration of aspirin with N - [4 - (5 - nitro - 2 - furyl) - 2 - thiazolyl] - formamide (FANFT) to rats resulted in a reduced incidence o...

{ "entities": { "chemical": [ { "text": "aspirin", "start": 10, "end": 17 }, { "text": "N - [4 - (5 - nitro - 2 - furyl) - 2 - thiazolyl] - formamide", "start": 21, "end": 82 }, { "text": "aspirin", "start": 196, ...

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Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy? The effect of nitroglycerin on heart rate and systolic blood pressure was compared in 5 normal subjects, 12 diabetic subjects without autonomic neuropathy, and 5 diabetic subjects with autonomic neuropathy. The magnitude and time cou...

{ "entities": { "chemical": [ { "text": "nitroglycerin", "start": 39, "end": 52 }, { "text": "nitroglycerin", "start": 101, "end": 114 }, { "text": "nitroglycerin", "start": 404, "end": 417 } ], "di...

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Characterization of estrogen - induced adenohypophyseal tumors in the Fischer 344 rat. Pituitary tumors were induced in F344 female rats by chronic treatment with diethylstilbestrol (DES, 8 - 10 mg) implanted subcutaneously in silastic capsules. Over a range of 1 - 150 days of DES treatment, pairs of control and DES - ...

{ "entities": { "chemical": [ { "text": "estrogen", "start": 20, "end": 28 }, { "text": "diethylstilbestrol", "start": 163, "end": 181 }, { "text": "DES", "start": 183, "end": 186 }, { "text":...

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Triamterene nephrolithiasis complicating dyazide therapy. A case of triamterene nephrolithiasis is reported in a man after 4 years of hydrochlorothiazide - triamterene therapy for hypertension. The stone passed spontaneously and was found to contain a triamterene metabolite admixed with uric acid salts. Factors affecti...

{ "entities": { "chemical": [ { "text": "Triamterene", "start": 0, "end": 11 }, { "text": "dyazide", "start": 41, "end": 48 }, { "text": "triamterene", "start": 68, "end": 79 }, { "text": "hyd...

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Metabolic involvement in adriamycin cardiotoxicity. The cardiotoxic effects of adriamycin were studied in mammalian myocardial cells in culture as a model system. Adriamycin inhibited cell growth and the rhythmic contractions characteristic of myocardial cells in culture. A possible involvement of energy metabolism was...

{ "entities": { "chemical": [ { "text": "adriamycin", "start": 25, "end": 35 }, { "text": "adriamycin", "start": 79, "end": 89 }, { "text": "Adriamycin", "start": 163, "end": 173 }, { "text": ...

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Age - dependent sensitivity of the rat to neurotoxic effects of streptomycin. Streptomycin sulfate (300 mg / kg s. c.) was injected for various periods into preweanling rats and for 3 weeks into weanling rats. Beginning at 8 days of age, body movement and hearing were examined for 6 and up to 17 weeks, respectively. Ab...

{ "entities": { "chemical": [ { "text": "streptomycin", "start": 64, "end": 76 }, { "text": "Streptomycin", "start": 78, "end": 90 }, { "text": "streptomycin", "start": 595, "end": 607 } ], "disease...

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Crescentic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis. This case study reveals an unusual finding of rapidly proliferative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiable causes for developing this disease. This p...

{ "entities": { "chemical": [ { "text": "rifampin", "start": 70, "end": 78 }, { "text": "rifampin", "start": 239, "end": 247 }, { "text": "rifampin", "start": 361, "end": 369 }, { "text": "iso...

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Time course of lipid peroxidation in puromycin aminonucleoside - induced nephropathy. Reactive oxygen species have been implicated in the pathogenesis of acute puromycin aminonucleoside (PAN) - induced nephropathy, with antioxidants significantly reducing the proteinuria. The temporal relationship between lipid peroxid...

{ "entities": { "chemical": [ { "text": "puromycin aminonucleoside", "start": 37, "end": 62 }, { "text": "oxygen", "start": 95, "end": 101 }, { "text": "puromycin aminonucleoside", "start": 160, "end": 185 ...

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Clomipramine - induced sleep disturbance does not impair its prolactin - releasing action. The present study was undertaken to examine the role of sleep disturbance, induced by clomipramine administration, on the secretory rate of prolactin (PRL) in addition to the direct drug effect. Two groups of supine subjects were...

{ "entities": { "chemical": [ { "text": "Clomipramine", "start": 0, "end": 12 }, { "text": "clomipramine", "start": 177, "end": 189 }, { "text": "clomipramine", "start": 503, "end": 515 }, { "...

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Angioedema following the intravenous administration of metoprolol. A 72 - year - old woman was admitted to the hospital with " flash " pulmonary edema, preceded by chest pain, requiring intubation. Her medical history included coronary artery disease with previous myocardial infarctions, hypertension, and diabetes mell...

{ "entities": { "chemical": [ { "text": "metoprolol", "start": 55, "end": 65 }, { "text": "lisinopril", "start": 363, "end": 373 }, { "text": "angiotensin", "start": 432, "end": 443 }, { "text...

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Effect of coniine on the developing chick embryo. Coniine, an alkaloid from Conium maculatum (poison hemlock), has been shown to be teratogenic in livestock. The major teratogenic outcome is arthrogryposis, presumably due to nicotinic receptor blockade. However, coniine has failed to produce arthrogryposis in rats or m...

{ "entities": { "chemical": [ { "text": "coniine", "start": 10, "end": 17 }, { "text": "Coniine", "start": 50, "end": 57 }, { "text": "coniine", "start": 263, "end": 270 }, { "text": "coniine"...

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