text stringlengths 183 360 | input stringlengths 183 360 | output stringclasses 1
value | answer_choices sequencelengths 0 0 | correct_output_index float64 |
|---|---|---|---|---|
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES Cn1c(CN2CCN(CC2)c3ccc(Cl)cc3)nc4ccccc14?
Options:
a: 0.40
b: 3.54
c: 1.00
d: 3.18
Answer: b | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES Cn1c(CN2CCN(CC2)c3ccc(Cl)cc3)nc4ccccc14?
Options:
a: 0.40
b: 3.54
c: 1.00
d: 3.18
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES COC(=O)[C@@H](N1CCc2sccc2C1)c3ccccc3Cl?
Options:
a.) 3.44
b.) 1.03
c.) 3.69
d.) 2.24
Answer: c | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES COC(=O)[C@@H](N1CCc2sccc2C1)c3ccccc3Cl?
Options:
a.) 3.44
b.) 1.03
c.) 3.69
d.) 2.24
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES OC[C@H](O)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3?
Options:
a.) 3.37
b.) 2.00
c.) 0.74
d.) -0.12
e.) 3.38
Answer: a | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES OC[C@H](O)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3?
Options:
a.) 3.37
b.) 2.00
c.) 0.74
d.) -0.12
e.) 3.38
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES Cc1cccc(C[C@H](NC(=O)c2cc(nn2C)C(C)(C)C)C(=O)NCC#N)c1?
Options:
a 2.71
b 2.31
c 3.10
Answer: c | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES Cc1cccc(C[C@H](NC(=O)c2cc(nn2C)C(C)(C)C)C(=O)NCC#N)c1?
Options:
a 2.71
b 2.31
c 3.10
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES OC1(CN2CCC1CC2)C#Cc3ccc(cc3)c4ccccc4?
Options:
a.) 1.97
b.) 2.68
c.) 3.14
Answer: c | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES OC1(CN2CCC1CC2)C#Cc3ccc(cc3)c4ccccc4?
Options:
a.) 1.97
b.) 2.68
c.) 3.14
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)NCc2ccccc2N3CCCCC3?
Options:
a.) 2.73
b.) 0.75
c.) -0.72
d.) 3.50
e.) 1.58
f.) 3.64
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)NCc2ccccc2N3CCCCC3?
Options:
a.) 2.73
b.) 0.75
c.) -0.72
d.) 3.50
e.) 1.58
f.) 3.64
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CNc1cccc(CCOc2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2C)n1?
Options:
a. 2.70
b. 0.34
c. 2.80
d. 1.06
Answer: b | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CNc1cccc(CCOc2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2C)n1?
Options:
a. 2.70
b. 0.34
c. 2.80
d. 1.06
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES COc1ccc(cc1)C2=COc3cc(OC)cc(OC)c3C2=O?
Options:
a.) 3.05
b.) 1.91
c.) 3.15
d.) 2.51
e.) 2.03
f.) 2.00
Answer: a | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES COc1ccc(cc1)C2=COc3cc(OC)cc(OC)c3C2=O?
Options:
a.) 3.05
b.) 1.91
c.) 3.15
d.) 2.51
e.) 2.03
f.) 2.00
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES CS(=O)(=O)c1ccc(Oc2ccc(cc2)C#C[C@]3(O)CN4CCC3CC4)cc1?
Options:
(a) 3.41
(b) 1.51
(c) 4.48
(d) 2.93
Answer: b | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES CS(=O)(=O)c1ccc(Oc2ccc(cc2)C#C[C@]3(O)CN4CCC3CC4)cc1?
Options:
(a) 3.41
(b) 1.51
(c) 4.48
(d) 2.93
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES C[C@H](Nc1nc(Nc2cc(C)[nH]n2)c(C)nc1C#N)c3ccc(F)cn3?
Options:
a) 3.40
b) 2.54
c) 4.20
d) 2.61
e) 3.20
Answer: d | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES C[C@H](Nc1nc(Nc2cc(C)[nH]n2)c(C)nc1C#N)c3ccc(F)cn3?
Options:
a) 3.40
b) 2.54
c) 4.20
d) 2.61
e) 3.20
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES CCCSc1ncccc1C(=O)N2CCCC2c3ccncc3?
Options:
(a) 1.95
(b) 3.08
(c) 2.20
(d) -1.01
(e) 2.70
Answer: a | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES CCCSc1ncccc1C(=O)N2CCCC2c3ccncc3?
Options:
(a) 1.95
(b) 3.08
(c) 2.20
(d) -1.01
(e) 2.70
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC1CCCCC1NC(=O)c2cnn(c2NS(=O)(=O)c3ccc(C)cc3)c4ccccc4?
Options:
a) 1.79
b) 4.36
c) 1.34
d) -0.08
e) 2.51
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC1CCCCC1NC(=O)c2cnn(c2NS(=O)(=O)c3ccc(C)cc3)c4ccccc4?
Options:
a) 1.79
b) 4.36
c) 1.34
d) -0.08
e) 2.51
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES Nc1ccc(cc1)c2nc3ccc(O)cc3s2?
Options:
a.) 0.08
b.) 3.20
c.) 2.21
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES Nc1ccc(cc1)c2nc3ccc(O)cc3s2?
Options:
a.) 0.08
b.) 3.20
c.) 2.21
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES COc1ccc(cc1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NCC#N?
Options:
a: 2.53
b: -0.12
c: 2.87
d: 1.60
e: 1.89
Answer: d | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES COc1ccc(cc1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NCC#N?
Options:
a: 2.53
b: -0.12
c: 2.87
d: 1.60
e: 1.89
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(N(C)C)c2ccccc2?
Options:
a: 1.30
b: 3.77
c: 1.61
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES CCC(COC(=O)c1cc(OC)c(OC)c(OC)c1)(N(C)C)c2ccccc2?
Options:
a: 1.30
b: 3.77
c: 1.61
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES CO[C@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@H]1NCc4ccc5OCC(=O)Nc5n4?
Options:
a.) 0.60
b.) 0.32
c.) 1.68
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES CO[C@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@H]1NCc4ccc5OCC(=O)Nc5n4?
Options:
a.) 0.60
b.) 0.32
c.) 1.68
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES CC(C)(CCCCCOCCc1ccccc1)NCCc2ccc(O)c3nc(O)sc23?
Options:
a.) 2.29
b.) 0.66
c.) 3.30
d.) -0.12
e.) 2.73
f.) 2.92
Answer: f | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES CC(C)(CCCCCOCCc1ccccc1)NCCc2ccc(O)c3nc(O)sc23?
Options:
a.) 2.29
b.) 0.66
c.) 3.30
d.) -0.12
e.) 2.73
f.) 2.92
Answer: f | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES Clc1ccc(cc1)C(=O)Nc2oc(nn2)C(=O)Nc3ccc(cc3)N4CCOCC4?
Options:
a) -0.22
b) 1.92
c) 2.23
d) 3.23
e) 1.30
f) 0.60
Answer: b | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES Clc1ccc(cc1)C(=O)Nc2oc(nn2)C(=O)Nc3ccc(cc3)N4CCOCC4?
Options:
a) -0.22
b) 1.92
c) 2.23
d) 3.23
e) 1.30
f) 0.60
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES COc1ccc(Oc2cccc(CN3CCCC(C3)N4C=C(C)C(=O)NC4=O)c2)cc1?
Options:
(a) 2.60
(b) 0.97
(c) 3.17
(d) 0.46
(e) 1.20
(f) 4.38
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES COc1ccc(Oc2cccc(CN3CCCC(C3)N4C=C(C)C(=O)NC4=O)c2)cc1?
Options:
(a) 2.60
(b) 0.97
(c) 3.17
(d) 0.46
(e) 1.20
(f) 4.38
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES Clc1ccc(N2CCN(CC2)C(=O)CCCc3ccncc3)c(Cl)c1?
Options:
a.) 2.80
b.) 3.80
c.) 2.29
d.) 3.93
e.) 2.20
f.) 2.48
Answer: d | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES Clc1ccc(N2CCN(CC2)C(=O)CCCc3ccncc3)c(Cl)c1?
Options:
a.) 2.80
b.) 3.80
c.) 2.29
d.) 3.93
e.) 2.20
f.) 2.48
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES CSc1c(cnn1c2ccc(cc2)C(=O)O)C(=O)NC3C4CC5CC(CC3C5)C4?
Options:
(a) 1.20
(b) -0.66
(c) 3.43
(d) 1.61
Answer: a | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES CSc1c(cnn1c2ccc(cc2)C(=O)O)C(=O)NC3C4CC5CC(CC3C5)C4?
Options:
(a) 1.20
(b) -0.66
(c) 3.43
(d) 1.61
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES CNC1=Nc2ncccc2C(=NC1c3cccs3)c4occn4?
Options:
a: 2.85
b: 1.73
c: 1.91
d: 1.14
Answer: d | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES CNC1=Nc2ncccc2C(=NC1c3cccs3)c4occn4?
Options:
a: 2.85
b: 1.73
c: 1.91
d: 1.14
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES CS(=O)(=O)C1(CC1)c2cc(nc(n2)c3cccc4[nH]ccc34)N5CC6CCC(C5)O6?
Options:
a. -1.17
b. 1.29
c. 2.60
d. 3.19
e. 1.53
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES CS(=O)(=O)C1(CC1)c2cc(nc(n2)c3cccc4[nH]ccc34)N5CC6CCC(C5)O6?
Options:
a. -1.17
b. 1.29
c. 2.60
d. 3.19
e. 1.53
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES CN([C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc3ccc(cc3)n4cnnn4?
Options:
[a] 2.36
[b] 3.30
[c] 0.83
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES CN([C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc3ccc(cc3)n4cnnn4?
Options:
[a] 2.36
[b] 3.30
[c] 0.83
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C?
Options:
a.) 2.88
b.) 2.74
c.) 2.10
d.) 3.94
Answer: d | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C?
Options:
a.) 2.88
b.) 2.74
c.) 2.10
d.) 3.94
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3?
Options:
a. 2.76
b. 2.04
c. 2.72
d. 2.34
e. 3.25
Answer: d | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3?
Options:
a. 2.76
b. 2.04
c. 2.72
d. 2.34
e. 3.25
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES O=C(NCc1ccncc1)c2ccc(Oc3ccccc3C#N)cc2?
Options:
a) 2.86
b) 2.57
c) 3.30
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES O=C(NCc1ccncc1)c2ccc(Oc3ccccc3C#N)cc2?
Options:
a) 2.86
b) 2.57
c) 3.30
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CN(C)c1ccnc2sc(C(=O)NCc3ccccc3)c(N)c12?
Options:
a 3.62
b 3.25
c 1.13
d 0.77
e 2.54
Answer: a | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CN(C)c1ccnc2sc(C(=O)NCc3ccccc3)c(N)c12?
Options:
a 3.62
b 3.25
c 1.13
d 0.77
e 2.54
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES COc1ccc2ncc(C#N)c(CCN3CCC(CC3)NCc4cc5SCOc5cn4)c2c1?
Options:
a: 2.50
b: 3.50
c: 3.24
d: 3.98
e: 0.77
f: 2.55
Answer: f | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES COc1ccc2ncc(C#N)c(CCN3CCC(CC3)NCc4cc5SCOc5cn4)c2c1?
Options:
a: 2.50
b: 3.50
c: 3.24
d: 3.98
e: 0.77
f: 2.55
Answer: f | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES CNC(=O)C1(CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(cc3ccccc23)C#N)c4ccc(Cl)c(Cl)c4)CC1)N5CCCCC5=O?
Options:
a 2.02
b 2.59
c 2.78
d 2.30
e 1.35
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES CNC(=O)C1(CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(cc3ccccc23)C#N)c4ccc(Cl)c(Cl)c4)CC1)N5CCCCC5=O?
Options:
a 2.02
b 2.59
c 2.78
d 2.30
e 1.35
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES OB1N(C(=O)Nc2ccccc12)c3ccccc3?
Options:
a. 2.04
b. 4.12
c. 1.40
d. 1.08
Answer: c | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES OB1N(C(=O)Nc2ccccc12)c3ccccc3?
Options:
a. 2.04
b. 4.12
c. 1.40
d. 1.08
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC(C)N(CCC(C(=O)N)(c1ccccc1)c2ccccn2)C(C)C?
Options:
(a) 3.47
(b) 1.67
(c) -0.54
Answer: c | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC(C)N(CCC(C(=O)N)(c1ccccc1)c2ccccn2)C(C)C?
Options:
(a) 3.47
(b) 1.67
(c) -0.54
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES NC(=NC#N)c1sc(Nc2ccccc2)nc1N?
Options:
(a) 2.39
(b) 4.14
(c) 2.91
Answer: c | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES NC(=NC#N)c1sc(Nc2ccccc2)nc1N?
Options:
(a) 2.39
(b) 4.14
(c) 2.91
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES CCS(=O)(=O)c1ccc(c(C)c1)c2cc(ccc2O[C@H](C)C(=O)O)C(F)(F)F?
Options:
a.) -0.40
b.) 1.55
c.) 2.60
d.) 2.43
e.) 2.00
f.) 2.53
Answer: a | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES CCS(=O)(=O)c1ccc(c(C)c1)c2cc(ccc2O[C@H](C)C(=O)O)C(F)(F)F?
Options:
a.) -0.40
b.) 1.55
c.) 2.60
d.) 2.43
e.) 2.00
f.) 2.53
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES OC(=O)COc1ccc(cc1c2cc(ccc2F)C#N)C(F)(F)F?
Options:
a) -0.27
b) -0.16
c) 0.80
d) 1.20
Answer: b | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES OC(=O)COc1ccc(cc1c2cc(ccc2F)C#N)C(F)(F)F?
Options:
a) -0.27
b) -0.16
c) 0.80
d) 1.20
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES COc1ccc(cn1)C2=Cc3c(C)nc(N)nc3N([C@@H]4CC[C@H](CC4)OCCO)C2=O?
Options:
a. 0.80
b. 0.77
c. 2.20
d. 1.25
e. 4.00
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES COc1ccc(cn1)C2=Cc3c(C)nc(N)nc3N([C@@H]4CC[C@H](CC4)OCCO)C2=O?
Options:
a. 0.80
b. 0.77
c. 2.20
d. 1.25
e. 4.00
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES CC(Nc1ncnc2ccccc12)c3ccccc3?
Options:
(a) 3.40
(b) 1.70
(c) 1.20
(d) 3.90
(e) 0.30
Answer: a | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES CC(Nc1ncnc2ccccc12)c3ccccc3?
Options:
(a) 3.40
(b) 1.70
(c) 1.20
(d) 3.90
(e) 0.30
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES CC(C)c1ccc2Oc3nc(N)c(cc3C(=O)c2c1)C(=O)O?
Options:
a 2.51
b 1.20
c 2.79
d 1.10
Answer: d | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES CC(C)c1ccc2Oc3nc(N)c(cc3C(=O)c2c1)C(=O)O?
Options:
a 2.51
b 1.20
c 2.79
d 1.10
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES O[C@@H](CNCCCOCCOCCc1cccc2ccccc12)c3ccc(O)c4NC(=O)Sc34?
Options:
[a] 2.35
[b] 4.10
[c] 2.39
[d] 2.70
[e] 2.28
[f] 2.77
Answer: e | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES O[C@@H](CNCCCOCCOCCc1cccc2ccccc12)c3ccc(O)c4NC(=O)Sc34?
Options:
[a] 2.35
[b] 4.10
[c] 2.39
[d] 2.70
[e] 2.28
[f] 2.77
Answer: e | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COc1ccccc1Cn2c(C)nc3ccccc23?
Options:
a) 0.76
b) 3.47
c) 0.87
d) 1.80
e) 3.44
f) 0.31
Answer: b | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COc1ccccc1Cn2c(C)nc3ccccc23?
Options:
a) 0.76
b) 3.47
c) 0.87
d) 1.80
e) 3.44
f) 0.31
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES NC(Cc1c[nH]c2ccccc12)C(=O)O?
Options:
[a] 1.20
[b] 0.48
[c] 0.22
[d] -1.17
[e] 3.33
Answer: d | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES NC(Cc1c[nH]c2ccccc12)C(=O)O?
Options:
[a] 1.20
[b] 0.48
[c] 0.22
[d] -1.17
[e] 3.33
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES OC(=O)CCC[C@H]1[C@@H](Cc2ccccc12)NC(=O)c3cc4cc(F)ccc4[nH]3?
Options:
(a) 0.02
(b) 2.94
(c) 2.81
(d) 1.95
(e) 2.00
(f) 3.85
Answer: d | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES OC(=O)CCC[C@H]1[C@@H](Cc2ccccc12)NC(=O)c3cc4cc(F)ccc4[nH]3?
Options:
(a) 0.02
(b) 2.94
(c) 2.81
(d) 1.95
(e) 2.00
(f) 3.85
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES C[C@H](NC(=O)c1c(C)nn(C2CCCC2)c1NS(=O)(=O)c3ccc(C)cc3)C(C)(C)C?
Options:
a: 0.07
b: 3.49
c: 1.60
d: 1.51
e: 2.00
Answer: e | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES C[C@H](NC(=O)c1c(C)nn(C2CCCC2)c1NS(=O)(=O)c3ccc(C)cc3)C(C)(C)C?
Options:
a: 0.07
b: 3.49
c: 1.60
d: 1.51
e: 2.00
Answer: e | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES COCCNC(=O)c1cccc(Nc2ncc3cc(ccc3n2)c4ccncc4)c1?
Options:
(a) 1.89
(b) 1.00
(c) 3.21
(d) 1.82
Answer: c | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES COCCNC(=O)c1cccc(Nc2ncc3cc(ccc3n2)c4ccncc4)c1?
Options:
(a) 1.89
(b) 1.00
(c) 3.21
(d) 1.82
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES NC(=O)c1cc(F)cc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1?
Options:
a) 2.14
b) 0.67
c) 3.32
d) 0.70
Answer: a | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES NC(=O)c1cc(F)cc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1?
Options:
a) 2.14
b) 0.67
c) 3.32
d) 0.70
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES O=C1NC(=NC(=C1C#N)c2ccccc2)SCCc3ccccc3?
Options:
a. 1.71
b. 2.89
c. 3.60
d. 3.22
e. 2.00
f. 0.27
Answer: a | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES O=C1NC(=NC(=C1C#N)c2ccccc2)SCCc3ccccc3?
Options:
a. 1.71
b. 2.89
c. 3.60
d. 3.22
e. 2.00
f. 0.27
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES OC(C(=O)OC1CN2CCC1CC2)(c3ccccc3)c4ccccc4?
Options:
a) 1.19
b) 1.43
c) 2.24
d) 1.40
e) 0.39
Answer: a | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES OC(C(=O)OC1CN2CCC1CC2)(c3ccccc3)c4ccccc4?
Options:
a) 1.19
b) 1.43
c) 2.24
d) 1.40
e) 0.39
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES Cc1ccccc1NC(=O)CCS(=O)(=O)c2ccc(Br)s2?
Options:
a 2.80
b 3.98
c 0.81
d 2.70
e 1.75
Answer: d | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES Cc1ccccc1NC(=O)CCS(=O)(=O)c2ccc(Br)s2?
Options:
a 2.80
b 3.98
c 0.81
d 2.70
e 1.75
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)N(C)C)ncc2F?
Options:
a 3.30
b -1.33
c 2.34
d 1.81
e 2.77
f 1.78
Answer: e | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient of the SMILES CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)N(C)C)ncc2F?
Options:
a 3.30
b -1.33
c 2.34
d 1.81
e 2.77
f 1.78
Answer: e | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES O=C(COc1ccccc1)c2ccccc2?
Options:
[a] 3.80
[b] 2.87
[c] 1.83
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES O=C(COc1ccccc1)c2ccccc2?
Options:
[a] 3.80
[b] 2.87
[c] 1.83
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN4CCCC4?
Options:
[a] -0.94
[b] 3.13
[c] 1.08
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN4CCCC4?
Options:
[a] -0.94
[b] 3.13
[c] 1.08
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES O=C1CCOc2cc(COc3ccccc3)ccc12?
Options:
(a) 1.90
(b) 3.00
(c) 0.75
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES O=C1CCOc2cc(COc3ccccc3)ccc12?
Options:
(a) 1.90
(b) 3.00
(c) 0.75
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES CNC(=O)c1ccc(CC(=O)N(C)C2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1?
Options:
[a] -0.51
[b] 2.80
[c] 0.37
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES CNC(=O)c1ccc(CC(=O)N(C)C2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1?
Options:
[a] -0.51
[b] 2.80
[c] 0.37
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COCCNCc1ccc(CCNC[C@H](O)c2ccc(O)c3NC(=O)Sc23)cc1?
Options:
a. -0.54
b. 0.76
c. 4.00
d. 1.33
Answer: a | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COCCNCc1ccc(CCNC[C@H](O)c2ccc(O)c3NC(=O)Sc23)cc1?
Options:
a. -0.54
b. 0.76
c. 4.00
d. 1.33
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES Cn1cncc1c2c3C(=O)N(CC#C)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56?
Options:
a) 0.71
b) 1.66
c) 3.16
d) 1.98
e) 1.69
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES Cn1cncc1c2c3C(=O)N(CC#C)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56?
Options:
a) 0.71
b) 1.66
c) 3.16
d) 1.98
e) 1.69
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES C[C@H](NC(=O)c1cccnc1Oc2ccccc2)c3ccccc3?
Options:
[a] 2.69
[b] 2.27
[c] 2.91
[d] 2.37
Answer: c | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES C[C@H](NC(=O)c1cccnc1Oc2ccccc2)c3ccccc3?
Options:
[a] 2.69
[b] 2.27
[c] 2.91
[d] 2.37
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Clc1ccc(CN2CC3CNCC(C2)O3)cc1C(=O)NCC45CC6CC(CC(C6)C4)C5?
Options:
(a) 3.11
(b) 0.67
(c) 1.55
Answer: c | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Clc1ccc(CN2CC3CNCC(C2)O3)cc1C(=O)NCC45CC6CC(CC(C6)C4)C5?
Options:
(a) 3.11
(b) 0.67
(c) 1.55
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1?
Options:
(a) 4.10
(b) -0.16
(c) 0.60
(d) 0.20
Answer: d | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1?
Options:
(a) 4.10
(b) -0.16
(c) 0.60
(d) 0.20
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES Cc1cc(CCC2CCN(CC2)S(=O)(=O)CC3(CCOCC3)N(O)C=O)c(C)cn1?
Options:
(a) 2.65
(b) 2.74
(c) 1.43
(d) 1.81
(e) -0.46
(f) 3.15
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES Cc1cc(CCC2CCN(CC2)S(=O)(=O)CC3(CCOCC3)N(O)C=O)c(C)cn1?
Options:
(a) 2.65
(b) 2.74
(c) 1.43
(d) 1.81
(e) -0.46
(f) 3.15
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES C[C@H](Nc1ncc(F)c(Nc2cc([nH]n2)C3CC3)n1)c4ncc(F)cn4?
Options:
[a] 2.47
[b] 2.88
[c] 3.50
[d] 3.40
Answer: a | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES C[C@H](Nc1ncc(F)c(Nc2cc([nH]n2)C3CC3)n1)c4ncc(F)cn4?
Options:
[a] 2.47
[b] 2.88
[c] 3.50
[d] 3.40
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES CC(=O)Nc1ccc2c(c1)c(cn2CCCO)c3cc(NC4CC4)n5ncc(C#N)c5n3?
Options:
a 0.15
b 2.48
c 4.00
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES CC(=O)Nc1ccc2c(c1)c(cn2CCCO)c3cc(NC4CC4)n5ncc(C#N)c5n3?
Options:
a 0.15
b 2.48
c 4.00
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC1COc2c(N3CCN(C)CC3)c(F)cc4C(=O)C(=CN1c24)C(=O)O?
Options:
a 1.74
b -0.45
c 3.66
d 0.24
e 2.30
f 4.13
Answer: b | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC1COc2c(N3CCN(C)CC3)c(F)cc4C(=O)C(=CN1c24)C(=O)O?
Options:
a 1.74
b -0.45
c 3.66
d 0.24
e 2.30
f 4.13
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES CC1(CC1)c2nc(ncc2C(=O)N[C@@H]3C4CC5CC3C[C@@](O)(C5)C4)N6CCOCC6?
Options:
a 2.00
b 4.40
c 1.00
Answer: a | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES CC1(CC1)c2nc(ncc2C(=O)N[C@@H]3C4CC5CC3C[C@@](O)(C5)C4)N6CCOCC6?
Options:
a 2.00
b 4.40
c 1.00
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COC(=O)c1ccc(C)c(NS(=O)(=O)c2ccc3N(C)SC(=O)c3c2)c1?
Options:
a -0.25
b 3.90
c 3.37
d 1.60
e 2.60
f 3.04
Answer: e | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COC(=O)c1ccc(C)c(NS(=O)(=O)c2ccc3N(C)SC(=O)c3c2)c1?
Options:
a -0.25
b 3.90
c 3.37
d 1.60
e 2.60
f 3.04
Answer: e | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES COc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O?
Options:
a) -0.09
b) 1.99
c) 3.50
d) 4.28
e) 0.70
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES COc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O?
Options:
a) -0.09
b) 1.99
c) 3.50
d) 4.28
e) 0.70
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES Fc1cc(cc(F)c1C2=CCN(CC2)C=O)N3C[C@H](COc4ccon4)OC3=O?
Options:
a.) 2.01
b.) -0.98
c.) 2.34
Answer: a | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES Fc1cc(cc(F)c1C2=CCN(CC2)C=O)N3C[C@H](COc4ccon4)OC3=O?
Options:
a.) 2.01
b.) -0.98
c.) 2.34
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC(C#C)N1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c3C1=O)c6cncn6C?
Options:
a. 3.50
b. 3.59
c. 2.74
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC(C#C)N1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c3C1=O)c6cncn6C?
Options:
a. 3.50
b. 3.59
c. 2.74
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES C[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1C(=O)Cc3ccccc3?
Options:
a. 0.18
b. 3.29
c. 1.58
Answer: a | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES C[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1C(=O)Cc3ccccc3?
Options:
a. 0.18
b. 3.29
c. 1.58
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Br)n[nH]1?
Options:
a. 2.79
b. 1.60
c. 2.21
d. 2.60
Answer: d | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Br)n[nH]1?
Options:
a. 2.79
b. 1.60
c. 2.21
d. 2.60
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Cc1nc(C)c(nc1C(=O)N)c2ccc([C@@H]3CC[C@@H](CC(=O)O)CC3)c(F)c2?
Options:
(a) 1.30
(b) 1.09
(c) 3.59
(d) -0.42
Answer: a | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Cc1nc(C)c(nc1C(=O)N)c2ccc([C@@H]3CC[C@@H](CC(=O)O)CC3)c(F)c2?
Options:
(a) 1.30
(b) 1.09
(c) 3.59
(d) -0.42
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES COc1ccnc(CCc2nc3c(C)ccnc3[nH]2)c1?
Options:
a. 2.10
b. 1.09
c. 2.77
d. 2.40
e. 1.85
Answer: a | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES COc1ccnc(CCc2nc3c(C)ccnc3[nH]2)c1?
Options:
a. 2.10
b. 1.09
c. 2.77
d. 2.40
e. 1.85
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES Cc1cc(CCCOc2c(Cl)cc(cc2Cl)C3=NCCO3)on1?
Options:
a: 3.88
b: 1.21
c: 3.72
d: 1.79
e: 0.33
f: -0.87
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES Cc1cc(CCCOc2c(Cl)cc(cc2Cl)C3=NCCO3)on1?
Options:
a: 3.88
b: 1.21
c: 3.72
d: 1.79
e: 0.33
f: -0.87
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12?
Options:
(a) 4.12
(b) 0.95
(c) 1.65
(d) 0.01
Answer: c | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient of the SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12?
Options:
(a) 4.12
(b) 0.95
(c) 1.65
(d) 0.01
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES CCN1CCN(CC1)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)cc2?
Options:
(a) 1.09
(b) 1.86
(c) 3.70
Answer: c | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES CCN1CCN(CC1)c2ccc(Nc3cc(ncn3)N(C)C(=O)Nc4c(Cl)c(OC)cc(OC)c4Cl)cc2?
Options:
(a) 1.09
(b) 1.86
(c) 3.70
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n3cnc4c(N)ncnc34?
Options:
a 2.12
b 2.20
c 2.00
d 0.38
e 3.93
Answer: b | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n3cnc4c(N)ncnc34?
Options:
a 2.12
b 2.20
c 2.00
d 0.38
e 3.93
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(O)c(Oc4ccccc4)c3)C(=O)NC1=O?
Options:
[a] 1.49
[b] 2.89
[c] 3.70
[d] 1.50
Answer: a | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(O)c(Oc4ccccc4)c3)C(=O)NC1=O?
Options:
[a] 1.49
[b] 2.89
[c] 3.70
[d] 1.50
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CNC(=C[N+](=O)[O-])NCCSCc1oc(CN(C)C)cc1?
Options:
a.) 2.65
b.) 1.32
c.) 3.92
d.) 2.95
e.) -0.95
Answer: e | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CNC(=C[N+](=O)[O-])NCCSCc1oc(CN(C)C)cc1?
Options:
a.) 2.65
b.) 1.32
c.) 3.92
d.) 2.95
e.) -0.95
Answer: e | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES FC(F)c1nc2ccccc2[nH]1?
Options:
a. 4.10
b. -0.70
c. 2.02
d. 1.70
e. 0.44
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES FC(F)c1nc2ccccc2[nH]1?
Options:
a. 4.10
b. -0.70
c. 2.02
d. 1.70
e. 0.44
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc3cccc(c3)C#N?
Options:
a 2.99
b 3.09
c 3.49
d 2.60
Answer: b | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc3cccc(c3)C#N?
Options:
a 2.99
b 3.09
c 3.49
d 2.60
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES COc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1N4CCN(C)CC4?
Options:
a) 3.00
b) 2.18
c) 2.20
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES COc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1N4CCN(C)CC4?
Options:
a) 3.00
b) 2.18
c) 2.20
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES Oc1ccccc1OC(=O)c2cccc3ccccc23?
Options:
a) 0.40
b) 4.40
c) -0.09
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES Oc1ccccc1OC(=O)c2cccc3ccccc23?
Options:
a) 0.40
b) 4.40
c) -0.09
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES COc1ccccc1CNc2cc(C)ccn2?
Options:
a 0.87
b 2.30
c 1.10
d 1.45
e 3.28
f 3.50
Answer: e | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES COc1ccccc1CNc2cc(C)ccn2?
Options:
a 0.87
b 2.30
c 1.10
d 1.45
e 3.28
f 3.50
Answer: e | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES Nc1nc(Nc2cccc(Br)c2)c3nc[nH]c3n1?
Options:
a. 2.70
b. 3.35
c. 3.04
d. 3.21
e. 3.37
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient of the SMILES Nc1nc(Nc2cccc(Br)c2)c3nc[nH]c3n1?
Options:
a. 2.70
b. 3.35
c. 3.04
d. 3.21
e. 3.37
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES Nc1c2CCN(c3ccccc3)c2nc4ccc(Br)cc14?
Options:
a: 1.63
b: 3.12
c: 0.98
d: 2.10
e: 2.46
Answer: b | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the logD at pH 7.4 of the SMILES Nc1c2CCN(c3ccccc3)c2nc4ccc(Br)cc14?
Options:
a: 1.63
b: 3.12
c: 0.98
d: 2.10
e: 2.46
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)N(c2ccc(C)cc2)c3ccc(C)cc3?
Options:
a 0.06
b 1.50
c 1.73
Answer: a | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)N(c2ccc(C)cc2)c3ccc(C)cc3?
Options:
a 0.06
b 1.50
c 1.73
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES CC(C)C[C@H](N)c1oc(nn1)S(=O)(=O)Cc2ccc(F)cc2?
Options:
a.) 1.11
b.) 1.84
c.) 1.50
d.) -0.45
Answer: a | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the logD at pH 7.4 of the SMILES CC(C)C[C@H](N)c1oc(nn1)S(=O)(=O)Cc2ccc(F)cc2?
Options:
a.) 1.11
b.) 1.84
c.) 1.50
d.) -0.45
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC(C)COc1cccc(c1)C(=O)Nc2ccc(C)c(c2)C(=O)Nc3cccnc3?
Options:
a.) 2.56
b.) 0.84
c.) 2.81
d.) 0.37
e.) 2.48
Answer: c | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CC(C)COc1cccc(c1)C(=O)Nc2ccc(C)c(c2)C(=O)Nc3cccnc3?
Options:
a.) 2.56
b.) 0.84
c.) 2.81
d.) 0.37
e.) 2.48
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES COc1ccc(OC)c(CNC(=O)c2cccnc2Oc3ccccc3)c1?
Options:
a.) 3.86
b.) 2.33
c.) 1.72
d.) 3.52
e.) 2.99
f.) 3.10
Answer: d | Task: Please answer the multiple choice question below with a, b, c, d, e, or f.
Question: What is the logD at pH 7.4 of the SMILES COc1ccc(OC)c(CNC(=O)c2cccnc2Oc3ccccc3)c1?
Options:
a.) 3.86
b.) 2.33
c.) 1.72
d.) 3.52
e.) 2.99
f.) 3.10
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES NC1(CCC1)c2ccc(cc2)c3nc4C=CN5C(=O)NN=C5c4cc3c6ccccc6?
Options:
[a] 4.29
[b] 2.50
[c] 1.93
[d] 2.18
Answer: b | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES NC1(CCC1)c2ccc(cc2)c3nc4C=CN5C(=O)NN=C5c4cc3c6ccccc6?
Options:
[a] 4.29
[b] 2.50
[c] 1.93
[d] 2.18
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES Clc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1?
Options:
a) 1.33
b) 1.46
c) 1.41
Answer: a | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES Clc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1?
Options:
a) 1.33
b) 1.46
c) 1.41
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)C4CCC4?
Options:
a.) 3.20
b.) 2.57
c.) 2.00
Answer: a | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)C4CCC4?
Options:
a.) 3.20
b.) 2.57
c.) 2.00
Answer: a | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Nc1c(NC2CC3CCC2C3)nc(nc1N4CCOCC4)C#N?
Options:
a 3.62
b 3.53
c 0.16
d 0.68
e 2.59
Answer: b | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Nc1c(NC2CC3CCC2C3)nc(nc1N4CCOCC4)C#N?
Options:
a 3.62
b 3.53
c 0.16
d 0.68
e 2.59
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24?
Options:
a) 2.32
b) 2.19
c) 3.08
Answer: c | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24?
Options:
a) 2.32
b) 2.19
c) 3.08
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Cc1ncc(nc1C(=O)N)c2ccc(cc2)[C@@H]3CC[C@@H](CC(=O)O)CC3?
Options:
[a] 0.70
[b] 2.25
[c] 0.64
[d] 1.00
Answer: d | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Cc1ncc(nc1C(=O)N)c2ccc(cc2)[C@@H]3CC[C@@H](CC(=O)O)CC3?
Options:
[a] 0.70
[b] 2.25
[c] 0.64
[d] 1.00
Answer: d | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)cc4Cl?
Options:
(a) 1.02
(b) 1.52
(c) 0.70
(d) 1.00
Answer: b | Task: Please answer the multiple choice question below with a, b, c, or d.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)cc4Cl?
Options:
(a) 1.02
(b) 1.52
(c) 0.70
(d) 1.00
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES O=C1C=COc2cc(OCc3ccccc3)ccc12?
Options:
(a) -0.43
(b) 3.33
(c) -1.34
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES O=C1C=COc2cc(OCc3ccccc3)ccc12?
Options:
(a) -0.43
(b) 3.33
(c) -1.34
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES [O-][S+](c1ccccc1)c2ccc3nnnn3n2?
Options:
a: 1.27
b: 1.30
c: 0.79
Answer: c | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES [O-][S+](c1ccccc1)c2ccc3nnnn3n2?
Options:
a: 1.27
b: 1.30
c: 0.79
Answer: c | [] | null | |
Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Cc1ncc(nc1c2ccc(cc2)[C@@H]3CC[C@H](CC3)C(=O)O)C(=O)N?
Options:
a: 1.20
b: 0.22
c: 3.07
d: 3.27
e: 1.53
Answer: b | Task: Please answer the multiple choice question below with a, b, c, d, or e.
Question: What is the octanol/water distribution coefficient (logD at pH 7.4) of the SMILES Cc1ncc(nc1c2ccc(cc2)[C@@H]3CC[C@H](CC3)C(=O)O)C(=O)N?
Options:
a: 1.20
b: 0.22
c: 3.07
d: 3.27
e: 1.53
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1?
Options:
(a) 2.90
(b) 2.00
(c) 3.76
Answer: b | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the logD at pH 7.4 of the SMILES Nc1nnc(CCSCCc2nnc(NC(=O)Cc3ccccc3)s2)s1?
Options:
(a) 2.90
(b) 2.00
(c) 3.76
Answer: b | [] | null | |
Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES COc1cc(OC2CCN(CC2)C(=O)C)ccc1Nc3ncc(Cl)c(n3)c4cnc5ccccn45?
Options:
a 4.00
b 0.22
c 2.41
Answer: a | Task: Please answer the multiple choice question below with a, b, or c.
Question: What is the octanol/water distribution coefficient of the SMILES COc1cc(OC2CCN(CC2)C(=O)C)ccc1Nc3ncc(Cl)c(n3)c4cnc5ccccn45?
Options:
a 4.00
b 0.22
c 2.41
Answer: a | [] | null |
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Dataset Details
Dataset Description
Experimental results of octanol/water distribution coefficient (logD at pH 7.4).
- Curated by:
- License: CC BY-SA 3.0
Dataset Sources
- original dataset link
- original meta data
- original dataset link from moleculenet
- original report card
- original dataset license from chembl
- used dataset license
Citation
BibTeX:
@techreport{hersey2015chembl,
title={ChEMBL Deposited Data Set-AZ dataset},
author={Hersey, Anne},
year={2015},
institution={Technical Report, Technical report, EMBL-EBI, 2015. https://www. ebi. ac. uk}
}
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