Meta-Analysis
Collection
https://github.com/iafcy/MetaAnalysis • 4 items • Updated
pmid stringclasses 42
values | meta_analysis_title stringclasses 42
values | meta_analysis_question stringclasses 42
values | criteria stringclasses 42
values | subgroup stringclasses 242
values | key_reference_title stringclasses 922
values | key_reference_abstract stringclasses 921
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24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome. | ## BACKGROUND
There is controversy regarding the application of transfusion triggers in cardiac surgery. The goal of this study was to determine if lowering the hemoglobin threshold for red cell (RBC) transfusion to 8 g per dL after coronary artery bypass graft surgery would reduce blood use without adversely affecting... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. | ## CONTEXT
Perioperative red blood cell transfusion is commonly used to address anemia, an independent risk factor for morbidity and mortality after cardiac operations; however, evidence regarding optimal blood transfusion practice in patients undergoing cardiac surgery is lacking.
## OBJECTIVE
To define whether a rest... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy. | ## OBJECTIVE
To examine the impact of a restrictive vs. liberal transfusion strategy on arterial lactate and oxygen content differences in children with single-ventricle physiology post cavopulmonary connection. Children with single-ventricle physiology are routinely transfused postoperatively to increase systemic oxyg... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study). | Red blood cell transfusion is common in patients with acute myocardial infarction (AMI). However, observational data suggest that this practice may be associated with worse clinical outcomes and data from clinical trials are lacking in this population. We conducted a prospective multicenter randomized pilot trial in wh... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery. | ## BACKGROUND
It is important to determine the optimal hemoglobin (Hb) concentration for red blood cell (RBC) transfusion for patients undergoing cardiac surgery because increased mortality has been associated with the severity of anemia and exposure to RBCs. Because a definitive trial will require thousands of patient... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. | ## BACKGROUND
Prior trials suggest it is safe to defer transfusion at hemoglobin levels above 7 to 8 g/dL in most patients. Patients with acute coronary syndrome may benefit from higher hemoglobin levels.
## METHODS
We performed a pilot trial in 110 patients with acute coronary syndrome or stable angina undergoing card... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial. | ## OBJECTIVE
To investigate the safety and effects of a restrictive red blood cell (RBC) transfusion strategy in pediatric cardiac surgery patients.
## DESIGN
Randomized controlled trial.
## SETTING
Pediatric ICU in an academic tertiary care center, Leiden University Medical Center, Leiden, The Netherlands.
## PATIENTS... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. | ## BACKGROUND
To determine whether a restrictive strategy of red-cell transfusion and a liberal strategy produced equivalent results in critically ill patients, we compared the rates of death from all causes at 30 days and the severity of organ dysfunction.
## METHODS
We enrolled 838 critically ill patients with euvole... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Transfusion strategies for patients in pediatric intensive care units. | ## BACKGROUND
The optimal hemoglobin threshold for erythrocyte transfusions in critically ill children is unknown. We hypothesized that a restrictive transfusion strategy of using packed red cells that were leukocyte-reduced before storage would be as safe as a liberal transfusion strategy, as judged by the outcome of ... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Transfusion strategies for acute upper gastrointestinal bleeding. | ## BACKGROUND
The hemoglobin threshold for transfusion of red cells in patients with acute gastrointestinal bleeding is controversial. We compared the efficacy and safety of a restrictive transfusion strategy with those of a liberal transfusion strategy.
## METHODS
We enrolled 921 patients with severe acute upper gastr... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. | ## OBJECTIVE
To determine whether extremely low birth weight infants (ELBW) transfused at lower hemoglobin thresholds versus higher thresholds have different rates of survival or morbidity at discharge.
## STUDY DESIGN
Infants weighing <1000 g birth weight were randomly assigned within 48 hours of birth to a transfusio... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | A pilot randomized trial comparing symptomatic vs. hemoglobin-level-driven red blood cell transfusions following hip fracture. | ## BACKGROUND
The indications for transfusion have never been evaluated in an adequately sized clinical trial. A pilot study was conducted to plan larger clinical trials.
## STUDY DESIGN AND METHODS
Hip fracture patients undergoing surgical repair who had postoperative hemoglobin levels less than 10 g per dL were rando... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Silent myocardial ischaemia and haemoglobin concentration: a randomized controlled trial of transfusion strategy in lower limb arthroplasty. | ## BACKGROUND AND OBJECTIVES
Red cell transfusion is commonly used in orthopaedic surgery. Evidence suggests that a restrictive transfusion strategy may be safe for most patients. However, concern has been raised over the risks of anaemia in those with ischaemic cardiac disease. Perioperative silent myocardial ischaemi... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery. | ## BACKGROUND
Perioperative anemia leads to increased morbidity and mortality and potentially inhibits rehabilitation after hip fracture surgery. As such, the optimum transfusion threshold after hip fracture surgery is unknown.
## PATIENTS AND METHODS
A total of 120 elderly, cognitively intact hip fracture patients adm... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | A randomized comparison of transfusion triggers in elective orthopaedic surgery using leucocyte-depleted red blood cells. | ## OBJECTIVE
In elective orthopaedic hip- and knee replacement surgery patients, we studied the effect of implementation of a uniform transfusion policy on RBC usage.
## STUDY DESIGN AND METHODS
A randomized, controlled study. A new uniform, restrictive transfusion policy was compared with standard care, which varied a... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Liberal or restrictive transfusion in high-risk patients after hip surgery. | ## BACKGROUND
The hemoglobin threshold at which postoperative red-cell transfusion is warranted is controversial. We conducted a randomized trial to determine whether a higher threshold for blood transfusion would improve recovery in patients who had undergone surgery for hip fracture.
## METHODS
We enrolled 2016 patie... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Transfusion policy after severe postpartum haemorrhage: a randomised non-inferiority trial. | ## OBJECTIVE
To assess the effect of red blood cell (RBC) transfusion on quality of life in acutely anaemic women after postpartum haemorrhage.
## DESIGN
Randomised non-inferiority trial.
## SETTING
Thirty-seven Dutch university and general hospitals.
## POPULATION
Women with acute anaemia (haemoglobin 4.8-7.9 g/dl [3.... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | Red blood cell transfusion thresholds in pediatric patients with sepsis. | ## OBJECTIVES
In children with severe sepsis or septic shock, the optimal red blood cell transfusion threshold is unknown. We analyzed the subgroup of patients with sepsis and transfusion requirements in a pediatric intensive care unit study to determine the impact of a restrictive vs. liberal transfusion strategy on c... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | A comparison of conservative and aggressive transfusion regimens in the perioperative management of sickle cell disease. The Preoperative Transfusion in Sickle Cell Disease Study Group. | ## BACKGROUND
Preoperative transfusions are frequently given to prevent perioperative morbidity in patients with sickle cell anemia. There is no consensus, however, on the best regimen of transfusions for this purpose.
## METHODS
We conducted a multicenter study to compare the rates of perioperative complications among... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | The Transfusion Alternatives Preoperatively in Sickle Cell Disease (TAPS) study: a randomised, controlled, multicentre clinical trial. | ## BACKGROUND
No consensus exists on whether preoperative blood transfusions are beneficial in patients with sickle-cell disease. We assessed whether perioperative complication rates would be altered by preoperative transfusion.
## METHODS
We did a multicentre, randomised trial. Eligible patients were aged at least 1 y... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - All serious infections, combined | A liberal blood transfusion strategy after hip fracture surgery does not increase the risk of infection in frail elderly | Introduction.– Postoperative anaemia is common in frail elderly hip fracture patients. Blood transfusion down regulates immune responses. Numerous studies suggest that transfusions slightly increase the risk of infections. Our aim is to assess whether a liberal postoperative blood transfusion strategy increases the ris... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome. | ## BACKGROUND
There is controversy regarding the application of transfusion triggers in cardiac surgery. The goal of this study was to determine if lowering the hemoglobin threshold for red cell (RBC) transfusion to 8 g per dL after coronary artery bypass graft surgery would reduce blood use without adversely affecting... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. | ## CONTEXT
Perioperative red blood cell transfusion is commonly used to address anemia, an independent risk factor for morbidity and mortality after cardiac operations; however, evidence regarding optimal blood transfusion practice in patients undergoing cardiac surgery is lacking.
## OBJECTIVE
To define whether a rest... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy. | ## OBJECTIVE
To examine the impact of a restrictive vs. liberal transfusion strategy on arterial lactate and oxygen content differences in children with single-ventricle physiology post cavopulmonary connection. Children with single-ventricle physiology are routinely transfused postoperatively to increase systemic oxyg... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study). | Red blood cell transfusion is common in patients with acute myocardial infarction (AMI). However, observational data suggest that this practice may be associated with worse clinical outcomes and data from clinical trials are lacking in this population. We conducted a prospective multicenter randomized pilot trial in wh... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery. | ## BACKGROUND
It is important to determine the optimal hemoglobin (Hb) concentration for red blood cell (RBC) transfusion for patients undergoing cardiac surgery because increased mortality has been associated with the severity of anemia and exposure to RBCs. Because a definitive trial will require thousands of patient... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. | ## BACKGROUND
Prior trials suggest it is safe to defer transfusion at hemoglobin levels above 7 to 8 g/dL in most patients. Patients with acute coronary syndrome may benefit from higher hemoglobin levels.
## METHODS
We performed a pilot trial in 110 patients with acute coronary syndrome or stable angina undergoing card... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial. | ## OBJECTIVE
To investigate the safety and effects of a restrictive red blood cell (RBC) transfusion strategy in pediatric cardiac surgery patients.
## DESIGN
Randomized controlled trial.
## SETTING
Pediatric ICU in an academic tertiary care center, Leiden University Medical Center, Leiden, The Netherlands.
## PATIENTS... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. | ## BACKGROUND
To determine whether a restrictive strategy of red-cell transfusion and a liberal strategy produced equivalent results in critically ill patients, we compared the rates of death from all causes at 30 days and the severity of organ dysfunction.
## METHODS
We enrolled 838 critically ill patients with euvole... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Transfusion strategies for patients in pediatric intensive care units. | ## BACKGROUND
The optimal hemoglobin threshold for erythrocyte transfusions in critically ill children is unknown. We hypothesized that a restrictive transfusion strategy of using packed red cells that were leukocyte-reduced before storage would be as safe as a liberal transfusion strategy, as judged by the outcome of ... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Transfusion strategies for acute upper gastrointestinal bleeding. | ## BACKGROUND
The hemoglobin threshold for transfusion of red cells in patients with acute gastrointestinal bleeding is controversial. We compared the efficacy and safety of a restrictive transfusion strategy with those of a liberal transfusion strategy.
## METHODS
We enrolled 921 patients with severe acute upper gastr... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. | ## OBJECTIVE
To determine whether extremely low birth weight infants (ELBW) transfused at lower hemoglobin thresholds versus higher thresholds have different rates of survival or morbidity at discharge.
## STUDY DESIGN
Infants weighing <1000 g birth weight were randomly assigned within 48 hours of birth to a transfusio... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | A pilot randomized trial comparing symptomatic vs. hemoglobin-level-driven red blood cell transfusions following hip fracture. | ## BACKGROUND
The indications for transfusion have never been evaluated in an adequately sized clinical trial. A pilot study was conducted to plan larger clinical trials.
## STUDY DESIGN AND METHODS
Hip fracture patients undergoing surgical repair who had postoperative hemoglobin levels less than 10 g per dL were rando... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Silent myocardial ischaemia and haemoglobin concentration: a randomized controlled trial of transfusion strategy in lower limb arthroplasty. | ## BACKGROUND AND OBJECTIVES
Red cell transfusion is commonly used in orthopaedic surgery. Evidence suggests that a restrictive transfusion strategy may be safe for most patients. However, concern has been raised over the risks of anaemia in those with ischaemic cardiac disease. Perioperative silent myocardial ischaemi... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery. | ## BACKGROUND
Perioperative anemia leads to increased morbidity and mortality and potentially inhibits rehabilitation after hip fracture surgery. As such, the optimum transfusion threshold after hip fracture surgery is unknown.
## PATIENTS AND METHODS
A total of 120 elderly, cognitively intact hip fracture patients adm... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | A randomized comparison of transfusion triggers in elective orthopaedic surgery using leucocyte-depleted red blood cells. | ## OBJECTIVE
In elective orthopaedic hip- and knee replacement surgery patients, we studied the effect of implementation of a uniform transfusion policy on RBC usage.
## STUDY DESIGN AND METHODS
A randomized, controlled study. A new uniform, restrictive transfusion policy was compared with standard care, which varied a... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Liberal or restrictive transfusion in high-risk patients after hip surgery. | ## BACKGROUND
The hemoglobin threshold at which postoperative red-cell transfusion is warranted is controversial. We conducted a randomized trial to determine whether a higher threshold for blood transfusion would improve recovery in patients who had undergone surgery for hip fracture.
## METHODS
We enrolled 2016 patie... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Transfusion policy after severe postpartum haemorrhage: a randomised non-inferiority trial. | ## OBJECTIVE
To assess the effect of red blood cell (RBC) transfusion on quality of life in acutely anaemic women after postpartum haemorrhage.
## DESIGN
Randomised non-inferiority trial.
## SETTING
Thirty-seven Dutch university and general hospitals.
## POPULATION
Women with acute anaemia (haemoglobin 4.8-7.9 g/dl [3.... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | Red blood cell transfusion thresholds in pediatric patients with sepsis. | ## OBJECTIVES
In children with severe sepsis or septic shock, the optimal red blood cell transfusion threshold is unknown. We analyzed the subgroup of patients with sepsis and transfusion requirements in a pediatric intensive care unit study to determine the impact of a restrictive vs. liberal transfusion strategy on c... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | A comparison of conservative and aggressive transfusion regimens in the perioperative management of sickle cell disease. The Preoperative Transfusion in Sickle Cell Disease Study Group. | ## BACKGROUND
Preoperative transfusions are frequently given to prevent perioperative morbidity in patients with sickle cell anemia. There is no consensus, however, on the best regimen of transfusions for this purpose.
## METHODS
We conducted a multicenter study to compare the rates of perioperative complications among... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | The Transfusion Alternatives Preoperatively in Sickle Cell Disease (TAPS) study: a randomised, controlled, multicentre clinical trial. | ## BACKGROUND
No consensus exists on whether preoperative blood transfusions are beneficial in patients with sickle-cell disease. We assessed whether perioperative complication rates would be altered by preoperative transfusion.
## METHODS
We did a multicentre, randomised trial. Eligible patients were aged at least 1 y... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies - Specific infections | A liberal blood transfusion strategy after hip fracture surgery does not increase the risk of infection in frail elderly | Introduction.– Postoperative anaemia is common in frail elderly hip fracture patients. Blood transfusion down regulates immune responses. Numerous studies suggest that transfusions slightly increase the risk of infections. Our aim is to assess whether a liberal postoperative blood transfusion strategy increases the ris... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome. | ## BACKGROUND
There is controversy regarding the application of transfusion triggers in cardiac surgery. The goal of this study was to determine if lowering the hemoglobin threshold for red cell (RBC) transfusion to 8 g per dL after coronary artery bypass graft surgery would reduce blood use without adversely affecting... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. | ## CONTEXT
Perioperative red blood cell transfusion is commonly used to address anemia, an independent risk factor for morbidity and mortality after cardiac operations; however, evidence regarding optimal blood transfusion practice in patients undergoing cardiac surgery is lacking.
## OBJECTIVE
To define whether a rest... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy. | ## OBJECTIVE
To examine the impact of a restrictive vs. liberal transfusion strategy on arterial lactate and oxygen content differences in children with single-ventricle physiology post cavopulmonary connection. Children with single-ventricle physiology are routinely transfused postoperatively to increase systemic oxyg... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study). | Red blood cell transfusion is common in patients with acute myocardial infarction (AMI). However, observational data suggest that this practice may be associated with worse clinical outcomes and data from clinical trials are lacking in this population. We conducted a prospective multicenter randomized pilot trial in wh... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | A randomized controlled pilot study of adherence to transfusion strategies in cardiac surgery. | ## BACKGROUND
It is important to determine the optimal hemoglobin (Hb) concentration for red blood cell (RBC) transfusion for patients undergoing cardiac surgery because increased mortality has been associated with the severity of anemia and exposure to RBCs. Because a definitive trial will require thousands of patient... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. | ## BACKGROUND
Prior trials suggest it is safe to defer transfusion at hemoglobin levels above 7 to 8 g/dL in most patients. Patients with acute coronary syndrome may benefit from higher hemoglobin levels.
## METHODS
We performed a pilot trial in 110 patients with acute coronary syndrome or stable angina undergoing card... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial. | ## OBJECTIVE
To investigate the safety and effects of a restrictive red blood cell (RBC) transfusion strategy in pediatric cardiac surgery patients.
## DESIGN
Randomized controlled trial.
## SETTING
Pediatric ICU in an academic tertiary care center, Leiden University Medical Center, Leiden, The Netherlands.
## PATIENTS... | True |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. | ## BACKGROUND
To determine whether a restrictive strategy of red-cell transfusion and a liberal strategy produced equivalent results in critically ill patients, we compared the rates of death from all causes at 30 days and the severity of organ dysfunction.
## METHODS
We enrolled 838 critically ill patients with euvole... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | Transfusion strategies for patients in pediatric intensive care units. | ## BACKGROUND
The optimal hemoglobin threshold for erythrocyte transfusions in critically ill children is unknown. We hypothesized that a restrictive transfusion strategy of using packed red cells that were leukocyte-reduced before storage would be as safe as a liberal transfusion strategy, as judged by the outcome of ... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | Transfusion strategies for acute upper gastrointestinal bleeding. | ## BACKGROUND
The hemoglobin threshold for transfusion of red cells in patients with acute gastrointestinal bleeding is controversial. We compared the efficacy and safety of a restrictive transfusion strategy with those of a liberal transfusion strategy.
## METHODS
We enrolled 921 patients with severe acute upper gastr... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. | ## OBJECTIVE
To determine whether extremely low birth weight infants (ELBW) transfused at lower hemoglobin thresholds versus higher thresholds have different rates of survival or morbidity at discharge.
## STUDY DESIGN
Infants weighing <1000 g birth weight were randomly assigned within 48 hours of birth to a transfusio... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | A pilot randomized trial comparing symptomatic vs. hemoglobin-level-driven red blood cell transfusions following hip fracture. | ## BACKGROUND
The indications for transfusion have never been evaluated in an adequately sized clinical trial. A pilot study was conducted to plan larger clinical trials.
## STUDY DESIGN AND METHODS
Hip fracture patients undergoing surgical repair who had postoperative hemoglobin levels less than 10 g per dL were rando... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | Silent myocardial ischaemia and haemoglobin concentration: a randomized controlled trial of transfusion strategy in lower limb arthroplasty. | ## BACKGROUND AND OBJECTIVES
Red cell transfusion is commonly used in orthopaedic surgery. Evidence suggests that a restrictive transfusion strategy may be safe for most patients. However, concern has been raised over the risks of anaemia in those with ischaemic cardiac disease. Perioperative silent myocardial ischaemi... | False |
24691607 | Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. | Is there an association between red blood cell (RBC) transfusion strategies (restrictive vs. liberal) and the risk of health care-associated infections in hospitalized patients, and is this risk independent of leukocyte reduction? | Study selection was conducted through independent review. Two teams of independent reviewers (J. R. and D. D.; L. K. and M. A. M. R.) examined abstracts for eligibility based on study design (randomized trial) and comparators (RBC transfusion strategies). To divide the work effort, the first team reviewed entries prior... | Forest Plot of Risk Ratios for Infection Comparing Restrictive vs Liberal Transfusion Strategies by Patient Type - Cardiac | The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery. | ## BACKGROUND
Perioperative anemia leads to increased morbidity and mortality and potentially inhibits rehabilitation after hip fracture surgery. As such, the optimum transfusion threshold after hip fracture surgery is unknown.
## PATIENTS AND METHODS
A total of 120 elderly, cognitively intact hip fracture patients adm... | False |
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