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PubMed_Summ13939 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Collective chemotaxis, where single cells cannot climb a biochemical signaling gradient but clusters of cells can, has been observed in different biological contexts, including confluent tissues where there are no gaps or overlaps between cells. Although particle-based models have been developed that predict important features of collective chemotaxis, the mechanisms in those models depend on particle overlaps, and so it remains unclear if they can explain behavior in confluent systems. Here, we develop an open-source code that couples a two-dimensional Voronoi simulation for confluent cell mechanics to a dynamic chemical signal that can diffuse, advect, and/or degrade and use the code to study potential mechanisms for collective chemotaxis in cellular monolayers. We first study the impact of advection on collective chemotaxis and delineate a regime where advective terms are important. Next, we investigate two possible chemotactic mechanisms, contact inhibition of locomotion and heterotypic interfacial tension, and demonstrate that both can drive collective chemotaxis in certain parameter regimes. We further demonstrate that the scaling behavior of cluster motion is well captured by simple analytic theories.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Collective chemotaxis in a Voronoi model for confluent clusters."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Collective chemotaxis, where single cells cannot climb a biochemical signaling gradient but clusters of cells can, has been observed in different biological contexts, including confluent tissues where there are no gaps or overlaps between cells. Although particle-based models have been developed that predict important features of collective chemotaxis, the mechanisms in those models depend on particle overlaps, and so it remains unclear if they can explain behavior in confluent systems. Here, we develop an open-source code that couples a two-dimensional Voronoi simulation for confluent cell mechanics to a dynamic chemical signal that can diffuse, advect, and/or degrade and use the code to study potential mechanisms for collective chemotaxis in cellular monolayers. We first study the impact of advection on collective chemotaxis and delineate a regime where advective terms are important. Next, we investigate two possible chemotactic mechanisms, contact inhibition of locomotion and heterotypic interfacial tension, and demonstrate that both can drive collective chemotaxis in certain parameter regimes. We further demonstrate that the scaling behavior of cluster motion is well captured by simple analytic theories.
OUTPUT:
|
PubMed_Summ7825 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The study aims to evaluate outpatient satisfaction (OS) with health insurance drug dispensing at the central hospital in Vietnam and to explore the influential factors. A cross-sectional survey was conducted on adult outpatients via an adjusted SERVQUAL questionnaire. The questionnaire's internal consistency (Cronbach alpha) and construct validity (exploratory factor analysis) were considered. The difference between groups was solved using a \n OUTPUT:\n "
},
{
"from": "agent",
"value": "An Assessment of Outpatient Satisfaction with Hospital Pharmacy Quality and Influential Factors in the Context of the COVID-19 Pandemic."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The study aims to evaluate outpatient satisfaction (OS) with health insurance drug dispensing at the central hospital in Vietnam and to explore the influential factors. A cross-sectional survey was conducted on adult outpatients via an adjusted SERVQUAL questionnaire. The questionnaire's internal consistency (Cronbach alpha) and construct validity (exploratory factor analysis) were considered. The difference between groups was solved using a
OUTPUT:
|
PubMed_Summ4832 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: There have been disparate outcomes in the few studies that have looked at anatomic success and visual acuity (VA) in chronic retinal rhegmatogenous detachment (RRD) repair. Chronic retinal detachments (RD) without a posterior vitreous detachment (PVD) occur in young myopes often secondary to an atrophic hole. These patients are often asymptomatic, and studies report good surgical anatomic results. However, chronic RD with a PVD is symptomatic but presents late due to patient compliance. This paper aims to evaluate this lesser-studied chronic macula-off RD with PVD.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Outcomes of chronic macula-off retinal detachment repair."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: There have been disparate outcomes in the few studies that have looked at anatomic success and visual acuity (VA) in chronic retinal rhegmatogenous detachment (RRD) repair. Chronic retinal detachments (RD) without a posterior vitreous detachment (PVD) occur in young myopes often secondary to an atrophic hole. These patients are often asymptomatic, and studies report good surgical anatomic results. However, chronic RD with a PVD is symptomatic but presents late due to patient compliance. This paper aims to evaluate this lesser-studied chronic macula-off RD with PVD.
OUTPUT:
|
PubMed_Summ6871 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Narcolepsy, a neurologic disorder that leads to excessive daytime sleepiness, may represent a rare consequence of neoplastic lesions involving the sellar/parasellar and hypothalamic regions, the anatomical areas responsible for wakefulness. Optic pathway gliomas represent the most common neoplasm of these regions and present an excellent overall survival, while long-term neurologic impairments, such as visual loss, endocrinopathies, or sleep disorders, are the principal causes of morbidity. In this case report, we describe a non-NF1 patient suffering from a very extensive optical pathway glioma, who several years after the diagnosis in a radiological condition of stable disease, presented with severe narcolepsy, a rare complication, that led to the death of the patient.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Secondary Narcolepsy as Worsening Sign in a Pediatric Case of Optic Pathway Glioma."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Narcolepsy, a neurologic disorder that leads to excessive daytime sleepiness, may represent a rare consequence of neoplastic lesions involving the sellar/parasellar and hypothalamic regions, the anatomical areas responsible for wakefulness. Optic pathway gliomas represent the most common neoplasm of these regions and present an excellent overall survival, while long-term neurologic impairments, such as visual loss, endocrinopathies, or sleep disorders, are the principal causes of morbidity. In this case report, we describe a non-NF1 patient suffering from a very extensive optical pathway glioma, who several years after the diagnosis in a radiological condition of stable disease, presented with severe narcolepsy, a rare complication, that led to the death of the patient.
OUTPUT:
|
PubMed_Summ20168 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy necessitates optimization and maintenance of activated effector T cells (Teff). We prospectively collected and applied multi-omic analyses to paired pre- and post-treatment PDAC specimens collected in a platform neoadjuvant study of granulocyte-macrophage colony-stimulating factor-secreting allogeneic PDAC vaccine (GVAX) vaccine ± nivolumab (anti-programmed cell death protein 1 [PD-1]) to uncover sensitivity and resistance mechanisms. We show that GVAX-induced tertiary lymphoid aggregates become immune-regulatory sites in response to GVAX + nivolumab. Higher densities of tumor-associated neutrophils (TANs) following GVAX + nivolumab portend poorer overall survival (OS). Increased T cells expressing CD137 associated with cytotoxic Teff signatures and correlated with increased OS. Bulk and single-cell RNA sequencing found that nivolumab alters CD4\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy necessitates optimization and maintenance of activated effector T cells (Teff). We prospectively collected and applied multi-omic analyses to paired pre- and post-treatment PDAC specimens collected in a platform neoadjuvant study of granulocyte-macrophage colony-stimulating factor-secreting allogeneic PDAC vaccine (GVAX) vaccine ± nivolumab (anti-programmed cell death protein 1 [PD-1]) to uncover sensitivity and resistance mechanisms. We show that GVAX-induced tertiary lymphoid aggregates become immune-regulatory sites in response to GVAX + nivolumab. Higher densities of tumor-associated neutrophils (TANs) following GVAX + nivolumab portend poorer overall survival (OS). Increased T cells expressing CD137 associated with cytotoxic Teff signatures and correlated with increased OS. Bulk and single-cell RNA sequencing found that nivolumab alters CD4
OUTPUT:
|
PubMed_Summ18356 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Long duration spaceflight missions will require novel exercise systems to protect astronaut crew from the detrimental effects of microgravity exposure. The SPRINT protocol is a novel and promising exercise prescription that combines aerobic and resistive training using a flywheel device, and it was successfully employed in a 70-day bed-rest study as well as onboard the International Space Station. Our team created a VR simulation to further augment the SPRINT protocol when using a flywheel ergometer training device (the Multi-Mode Exercise Device or M-MED). The simulation aspired to maximal realism in a virtual river setting while providing real-time biometric feedback on heart rate performance to subjects. In this pilot study, five healthy, male, physically-active subjects aged 35 ± 9.0 years old underwent 2 weeks of SPRINT protocol, either with or without the VR simulation. After a 1-month washout period, subjects returned for a subsequent 2 weeks in the opposite VR condition. We measured physiological and cognitive variables of stress, performance, and well-being. While physiological effects did not suggest much difference with the VR condition over 2 weeks, metrics of motivation, affect, and mood restoration showed detectable differences, or trended toward more positive outcomes than exercise without VR. These results provide evidence that a well-designed VR \"exergaming\" simulation with biometric feedback could be a beneficial addition to exercise prescriptions, especially if users are exposed to isolation and confinement.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Virtual Reality \"exergames\": A promising countermeasure to improve motivation and restorative effects during long duration spaceflight missions."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Long duration spaceflight missions will require novel exercise systems to protect astronaut crew from the detrimental effects of microgravity exposure. The SPRINT protocol is a novel and promising exercise prescription that combines aerobic and resistive training using a flywheel device, and it was successfully employed in a 70-day bed-rest study as well as onboard the International Space Station. Our team created a VR simulation to further augment the SPRINT protocol when using a flywheel ergometer training device (the Multi-Mode Exercise Device or M-MED). The simulation aspired to maximal realism in a virtual river setting while providing real-time biometric feedback on heart rate performance to subjects. In this pilot study, five healthy, male, physically-active subjects aged 35 ± 9.0 years old underwent 2 weeks of SPRINT protocol, either with or without the VR simulation. After a 1-month washout period, subjects returned for a subsequent 2 weeks in the opposite VR condition. We measured physiological and cognitive variables of stress, performance, and well-being. While physiological effects did not suggest much difference with the VR condition over 2 weeks, metrics of motivation, affect, and mood restoration showed detectable differences, or trended toward more positive outcomes than exercise without VR. These results provide evidence that a well-designed VR "exergaming" simulation with biometric feedback could be a beneficial addition to exercise prescriptions, especially if users are exposed to isolation and confinement.
OUTPUT:
|
PubMed_Summ2430 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In recent years, the treatment of textile waste has attracted more and more attention around the world. The reuse of textile waste can contribute to the reduction of carbon emissions and the sustainable development of the economy. Herein, we proposed a facile and cost-effective approach to fabricating aerogel by using textile waste fibers as the matrix and polyvinyl alcohol (PVA) and glutaraldehyde (GA) as crosslinking agents. After being modified with methyltrimethoxysilane (MTMS) via chemical vapor deposition, both the interior and exterior of the textile waste aerogels exhibit a hydrophobic property with a water contact angle of up to 136.9° ± 2.3°. A comprehensive investigation of the structure, thermal properties, mechanical properties and oil absorption capacity of this aerogel shows its potential for building insulation and oil spill cleanup. The textile waste fibers aerogels have low density and high porosity, good thermal stability and outstanding heat insulation properties (K\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Fabrication of Textile Waste Fibers Aerogels with Excellent Oil/Organic Solvent Adsorption and Thermal Properties."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: In recent years, the treatment of textile waste has attracted more and more attention around the world. The reuse of textile waste can contribute to the reduction of carbon emissions and the sustainable development of the economy. Herein, we proposed a facile and cost-effective approach to fabricating aerogel by using textile waste fibers as the matrix and polyvinyl alcohol (PVA) and glutaraldehyde (GA) as crosslinking agents. After being modified with methyltrimethoxysilane (MTMS) via chemical vapor deposition, both the interior and exterior of the textile waste aerogels exhibit a hydrophobic property with a water contact angle of up to 136.9° ± 2.3°. A comprehensive investigation of the structure, thermal properties, mechanical properties and oil absorption capacity of this aerogel shows its potential for building insulation and oil spill cleanup. The textile waste fibers aerogels have low density and high porosity, good thermal stability and outstanding heat insulation properties (K
OUTPUT:
|
PubMed_Summ15140 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Background The potential causes or sources of embolic stroke of undetermined source (ESUS) vary. This study aimed to investigate the main cause of deep ESUS by evaluating nonstenotic intracranial atherosclerotic plaque. Methods and Results We retrospectively screened consecutive patients with unilateral anterior circulation ESUS. After excluding the patients with possible embolism from an extracranial artery such as aortic arch plaque, carotid plaque, and so on, the enrolled patients with ESUS were categorized into 2 groups: deep ESUS and cortical with/without deep ESUS. All patients underwent intracranial high-resolution magnetic resonance imaging to assess the characteristics of nonstenotic intracranial atherosclerotic plaque. Biomarkers of atrial cardiopathy (ie, P-wave terminal force in lead V1 on ECG, NT-proBNP [N-terminal pro-brain natriuretic peptide] and left atrial diameter) were collected. A total of 155 patients with ipsilateral nonstenotic intracranial atherosclerotic plaque were found, with 76 (49.0%) in deep ESUS and 79 (51.0%) in cortical with/without deep ESUS. We found more prevalent plaque in the M1 segment of the middle cerebral artery and the ostia of the perforator, with a smaller remodeling index plaque burden, and less frequent occurrence of complicated plaque in deep ESUS versus cortical with/without deep ESUS. Higher BNP (brain natriuretic peptide) levels and a higher prevalence of atrial cardiopathy in cortical with/without deep ESUS versus deep ESUS. Moreover, the discrimination of vulnerable plaque for predicting ESUS was significantly enhanced after adjusting for or further excluding patients with deep ESUS. Conclusions The current study provides the first high-resolution magnetic resonance imaging evidence that cortical with/without deep ESUS and deep ESUS should be 2 distinct entities and that atherosclerosis, not embolism, might be the main cause of deep ESUS.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Atherosclerosis as a Potential Cause of Deep Embolic Stroke of Undetermined Source: A 3T High-Resolution Magnetic Resonance Imaging Study."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Background The potential causes or sources of embolic stroke of undetermined source (ESUS) vary. This study aimed to investigate the main cause of deep ESUS by evaluating nonstenotic intracranial atherosclerotic plaque. Methods and Results We retrospectively screened consecutive patients with unilateral anterior circulation ESUS. After excluding the patients with possible embolism from an extracranial artery such as aortic arch plaque, carotid plaque, and so on, the enrolled patients with ESUS were categorized into 2 groups: deep ESUS and cortical with/without deep ESUS. All patients underwent intracranial high-resolution magnetic resonance imaging to assess the characteristics of nonstenotic intracranial atherosclerotic plaque. Biomarkers of atrial cardiopathy (ie, P-wave terminal force in lead V1 on ECG, NT-proBNP [N-terminal pro-brain natriuretic peptide] and left atrial diameter) were collected. A total of 155 patients with ipsilateral nonstenotic intracranial atherosclerotic plaque were found, with 76 (49.0%) in deep ESUS and 79 (51.0%) in cortical with/without deep ESUS. We found more prevalent plaque in the M1 segment of the middle cerebral artery and the ostia of the perforator, with a smaller remodeling index plaque burden, and less frequent occurrence of complicated plaque in deep ESUS versus cortical with/without deep ESUS. Higher BNP (brain natriuretic peptide) levels and a higher prevalence of atrial cardiopathy in cortical with/without deep ESUS versus deep ESUS. Moreover, the discrimination of vulnerable plaque for predicting ESUS was significantly enhanced after adjusting for or further excluding patients with deep ESUS. Conclusions The current study provides the first high-resolution magnetic resonance imaging evidence that cortical with/without deep ESUS and deep ESUS should be 2 distinct entities and that atherosclerosis, not embolism, might be the main cause of deep ESUS.
OUTPUT:
|
PubMed_Summ24253 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Clonal hematopoiesis of indeterminate potential (CHIP) leads to higher mortality, carries a cardiovascular risk and alters inflammation. All three aspects harbor overlaps with the clinical manifestation of COVID-19. This study aimed to identify the impact of CHIP on COVID-19 pathophysiology. 90 hospitalized patients were analyzed for CHIP. In addition, their disease course and outcome were evaluated. With a prevalence of 37.8%, the frequency of a CHIP-driver mutation was significantly higher than the prevalence expected based on median age (17%). CHIP increases the risk of hospitalization in the course of the disease but has no age-independent impact on the outcome within the group of hospitalized patients. Especially in younger patients (45 - 65 years), CHIP was associated with persistent lymphopenia. In older patients (> 65 years), on the other hand, CHIP-positive patients developed neutrophilia in the long run. To what extent increased values of cardiac biomarkers are caused by CHIP independent of age could not be elaborated solely based on this study. In conclusion, our results indicate an increased susceptibility to a severe course of COVID-19 requiring hospitalization associated with CHIP. Secondly, they link it to a differentially regulated cellular immune response under the pressure of SARS-CoV-2 infection. Hence, a patient's CHIP-status bears the potential to serve as biomarker for risk stratification and to early guide treatment of COVID-19 patients.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Increased prevalence of clonal hematopoiesis of indeterminate potential in hospitalized patients with COVID-19."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Clonal hematopoiesis of indeterminate potential (CHIP) leads to higher mortality, carries a cardiovascular risk and alters inflammation. All three aspects harbor overlaps with the clinical manifestation of COVID-19. This study aimed to identify the impact of CHIP on COVID-19 pathophysiology. 90 hospitalized patients were analyzed for CHIP. In addition, their disease course and outcome were evaluated. With a prevalence of 37.8%, the frequency of a CHIP-driver mutation was significantly higher than the prevalence expected based on median age (17%). CHIP increases the risk of hospitalization in the course of the disease but has no age-independent impact on the outcome within the group of hospitalized patients. Especially in younger patients (45 - 65 years), CHIP was associated with persistent lymphopenia. In older patients (> 65 years), on the other hand, CHIP-positive patients developed neutrophilia in the long run. To what extent increased values of cardiac biomarkers are caused by CHIP independent of age could not be elaborated solely based on this study. In conclusion, our results indicate an increased susceptibility to a severe course of COVID-19 requiring hospitalization associated with CHIP. Secondly, they link it to a differentially regulated cellular immune response under the pressure of SARS-CoV-2 infection. Hence, a patient's CHIP-status bears the potential to serve as biomarker for risk stratification and to early guide treatment of COVID-19 patients.
OUTPUT:
|
PubMed_Summ24368 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: [This corrects the article DOI: 10.3389/fsurg.2021.636791.].\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Corrigendum: Risk of urinary bladder cancer in patients with inflammatory bowel diseases: A meta-analysis."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: [This corrects the article DOI: 10.3389/fsurg.2021.636791.].
OUTPUT:
|
PubMed_Summ5487 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Nitric oxide (NO), a signaling molecule, regulates multiple biological functions, including a variety of physiological and pathological processes. In this regard, NO participates in cutaneous inflammations, modulation of mitochondrial functions, vascular diseases, COVID-19, neurologic diseases, and obesity. It also mediates changes in the skeletal muscle function. Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder characterized by the malfunction of phagocytes caused by mutations in some of the genes encoding subunits of the superoxide-generating phagocyte NADPH (NOX). The literature consulted shows that there is a relationship between the production of NO and the NADPH oxidase system, which regulates the persistence of NO in the medium. Nevertheless, the underlying mechanisms of the effects of NO on CGD remain unknown. In this paper, we briefly review the regulatory role of NO in CGD and its potential underlying mechanisms.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "The Multiple Faces of Nitric Oxide in Chronic Granulomatous Disease: A Comprehensive Update."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Nitric oxide (NO), a signaling molecule, regulates multiple biological functions, including a variety of physiological and pathological processes. In this regard, NO participates in cutaneous inflammations, modulation of mitochondrial functions, vascular diseases, COVID-19, neurologic diseases, and obesity. It also mediates changes in the skeletal muscle function. Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder characterized by the malfunction of phagocytes caused by mutations in some of the genes encoding subunits of the superoxide-generating phagocyte NADPH (NOX). The literature consulted shows that there is a relationship between the production of NO and the NADPH oxidase system, which regulates the persistence of NO in the medium. Nevertheless, the underlying mechanisms of the effects of NO on CGD remain unknown. In this paper, we briefly review the regulatory role of NO in CGD and its potential underlying mechanisms.
OUTPUT:
|
PubMed_Summ23599 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Plant-derived vesicles (PDVs) are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological functions. In the last decade, PDVs have gained much attention for their involvement in different biological processes, including intercellular communication and defense response, and recent scientific evidence has opened a new avenue for their applications in cancer treatment. Nevertheless, much remains unknown about these vesicles, and current research remains inconsistent. This review aims to provide a comprehensive introduction to PDVs, from their biological characteristics to purification methods, and to summarize the status of their potential development for cancer therapy.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Plant-derived nanovesicles: Current understanding and applications for cancer therapy."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Plant-derived vesicles (PDVs) are membranous structures that originate from plant cells and are responsible for multiple physiological and pathological functions. In the last decade, PDVs have gained much attention for their involvement in different biological processes, including intercellular communication and defense response, and recent scientific evidence has opened a new avenue for their applications in cancer treatment. Nevertheless, much remains unknown about these vesicles, and current research remains inconsistent. This review aims to provide a comprehensive introduction to PDVs, from their biological characteristics to purification methods, and to summarize the status of their potential development for cancer therapy.
OUTPUT:
|
PubMed_Summ21429 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: ATM; XRCC6 and LIG4 genes play an important role in repairing the double-strand DNA breaks and maintaining the genome stability. Single nucleotide polymorphisms (SNPs) in these genes could affect these genes expression and function. The aim of this study was to address the effect of SNP of the DNA repairing genes on corresponding gene expression as well as AML patient's outcome.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "DNA Repair Genes Polymorphisms: Impact on Acute Myeloid Leukemia Patients Outcome."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: ATM; XRCC6 and LIG4 genes play an important role in repairing the double-strand DNA breaks and maintaining the genome stability. Single nucleotide polymorphisms (SNPs) in these genes could affect these genes expression and function. The aim of this study was to address the effect of SNP of the DNA repairing genes on corresponding gene expression as well as AML patient's outcome.
OUTPUT:
|
PubMed_Summ19943 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Effectiveness of restocking programs in Marine Fully Protected Areas' (FPAs) can be highly affected by the movement behavior of the species to protect. We analyzed the data of 744 Palinurus elephas specimens tagged, relocated inside 12 FPAs, established in the seas surrounding Sardinia (central-western Mediterranean), and then recaptured. The overall aims were to characterize the individuals' movements after the relocation and to discuss strengths and weaknesses of the current FPAs' design. Almost 80% of tagged individuals travelled progressively increasing distances, as a function of the release distance, up to a maximum value of 11,500 m. Then, for larger release distances, individuals' mobility appeared reduced and more chaotic. A similar trend was found analyzing the distances travelled with respect to the FPAs with the highest number of recaptured individuals and to the size. These results allow to establish a threshold limit of the release distance, to take into account when designing FPAs, as a useful tool to keep a portion of the individuals into FPAs' borders, in order to both preserve the species and guarantee a spillover of individuals in the commercial areas.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Movement patterns analysis as a tool in Fully Protected Areas design: Influence of relocations on travelled distances of Palinurus elephas (Fabr. 1787) in Sardinian FPAs (central-western Mediterranean)."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Effectiveness of restocking programs in Marine Fully Protected Areas' (FPAs) can be highly affected by the movement behavior of the species to protect. We analyzed the data of 744 Palinurus elephas specimens tagged, relocated inside 12 FPAs, established in the seas surrounding Sardinia (central-western Mediterranean), and then recaptured. The overall aims were to characterize the individuals' movements after the relocation and to discuss strengths and weaknesses of the current FPAs' design. Almost 80% of tagged individuals travelled progressively increasing distances, as a function of the release distance, up to a maximum value of 11,500 m. Then, for larger release distances, individuals' mobility appeared reduced and more chaotic. A similar trend was found analyzing the distances travelled with respect to the FPAs with the highest number of recaptured individuals and to the size. These results allow to establish a threshold limit of the release distance, to take into account when designing FPAs, as a useful tool to keep a portion of the individuals into FPAs' borders, in order to both preserve the species and guarantee a spillover of individuals in the commercial areas.
OUTPUT:
|
PubMed_Summ11454 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Photocatalysis has been recognized as a feasible method in water and wastewater treatment. Compared to other methods such as adsorption and chemical oxidation, the use of photocatalyst in the advanced oxidation processes gives benefits such as a longer lifetime of the catalyst and less consumable chemicals. Currently, explorations into low-cost, effective photocatalysts for organic contaminated water are being developed. Within this scheme, an easily separated photocatalyst with other functionality, such as high adsorption, is important. In this research, preparation of a magnetic nanocomposite photocatalyst based on agricultural waste, palm leaves biochar impregnated nickel nanoparticles (Ni/BC), was investigated. The nanocomposite was prepared by direct pyrolysis of palm leaves impregnated with nickel (II) chloride precursor. Furthermore, the physicochemical characterization of the material was performed by using an X-ray diffractometer (XRD), scanning electron microscopy-energy dispersive X-ray fluorescence (SEM-EDX), transmission electron microscopy (TEM), gas sorption analysis, X-ray photoelectron spectroscopy (XPS) and vibrating sample magnetometer (VSM). The photocatalytic activity of Ni/BC was evaluated for methyl violet (MV) photocatalytic oxidation. The results from XRD, XPS and TEM analyses identified single nickel nanoparticles dispersed on the biochar structure ranging from 30-50 nm in size. The dispersed nickel nanoparticles increased the BET specific surface area of biochar from 3.92 m\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Nanocomposite of Nickel Nanoparticles-Impregnated Biochar from Palm Leaves as Highly Active and Magnetic Photocatalyst for Methyl Violet Photocatalytic Oxidation."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Photocatalysis has been recognized as a feasible method in water and wastewater treatment. Compared to other methods such as adsorption and chemical oxidation, the use of photocatalyst in the advanced oxidation processes gives benefits such as a longer lifetime of the catalyst and less consumable chemicals. Currently, explorations into low-cost, effective photocatalysts for organic contaminated water are being developed. Within this scheme, an easily separated photocatalyst with other functionality, such as high adsorption, is important. In this research, preparation of a magnetic nanocomposite photocatalyst based on agricultural waste, palm leaves biochar impregnated nickel nanoparticles (Ni/BC), was investigated. The nanocomposite was prepared by direct pyrolysis of palm leaves impregnated with nickel (II) chloride precursor. Furthermore, the physicochemical characterization of the material was performed by using an X-ray diffractometer (XRD), scanning electron microscopy-energy dispersive X-ray fluorescence (SEM-EDX), transmission electron microscopy (TEM), gas sorption analysis, X-ray photoelectron spectroscopy (XPS) and vibrating sample magnetometer (VSM). The photocatalytic activity of Ni/BC was evaluated for methyl violet (MV) photocatalytic oxidation. The results from XRD, XPS and TEM analyses identified single nickel nanoparticles dispersed on the biochar structure ranging from 30-50 nm in size. The dispersed nickel nanoparticles increased the BET specific surface area of biochar from 3.92 m
OUTPUT:
|
PubMed_Summ2825 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To establish the equivalent efficacy and comparable safety profile of biosimilar Acveris and referent eculizumab product Soliris used for the treatment of paroxysmal nocturnal hemoglobinuria (PNH).\n OUTPUT:\n "
},
{
"from": "agent",
"value": "[The efficacy and safety of eculizumab biosimilar in patients with paroxysmal nocturnal hemoglobinuria. Results of a phase III randomized open-label comparative clinical trial]."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: To establish the equivalent efficacy and comparable safety profile of biosimilar Acveris and referent eculizumab product Soliris used for the treatment of paroxysmal nocturnal hemoglobinuria (PNH).
OUTPUT:
|
PubMed_Summ3001 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Chronic kidney disease (CKD) is characterized by high mortality from cardiovascular diseases, the development of which is facilitated by traditional risk factors (typical for the general population) and by nontraditional ones (specific to patients with CKD) as well. These factors include also uremic toxins, for which a causal relationship has been established with specific pathological processes in patients with CKD, comprising the development of vascular dysfunction and accelerated progression of atherosclerosis. Urea has long been considered not as a uremic toxin, but as a marker of metabolic imbalance or dialysis efficiency (Kt/V) in CKD patients. In recent years, more and more publications have appeared on the study of the toxic effects of urea with the development of toxic-uremic complications and the phenotype of premature aging, common in CKD. It was found that an increase in urea levels in uremic syndrome causes damage to the intestinal epithelial barrier with translocation of bacterial toxins into the bloodstream and the development of systemic inflammation, provokes apoptosis of vascular smooth muscle cells, as well as endothelial dysfunction, which directly contributes to the development of cardiovascular complications. The indirect effects of increased urea levels are associated with carbamylation reactions, when isocyanic acid (a product of urea catabolism) changes the structure and function of proteins in the body. Carbamylation of proteins in CKD patients is associated with the development of renal fibrosis, atherosclerosis and anemia. Thus, urea is now regarded as an important negative agent in the pathogenesis of complications in CKD. Studies on a low-protein diet with using ketoanalogues of essential amino acids to minimize the accumulation of urea and other uremic toxins demonstrate the clinical benefit of such an intervention in slowing the progression of CKD and the development of cardiovascular complications.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "[The value of a low-protein diet and ketoanalogues of essential amino acids in the сontrol of protein carbamylation and toxic effects of urea in chronic kidney disease]."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Chronic kidney disease (CKD) is characterized by high mortality from cardiovascular diseases, the development of which is facilitated by traditional risk factors (typical for the general population) and by nontraditional ones (specific to patients with CKD) as well. These factors include also uremic toxins, for which a causal relationship has been established with specific pathological processes in patients with CKD, comprising the development of vascular dysfunction and accelerated progression of atherosclerosis. Urea has long been considered not as a uremic toxin, but as a marker of metabolic imbalance or dialysis efficiency (Kt/V) in CKD patients. In recent years, more and more publications have appeared on the study of the toxic effects of urea with the development of toxic-uremic complications and the phenotype of premature aging, common in CKD. It was found that an increase in urea levels in uremic syndrome causes damage to the intestinal epithelial barrier with translocation of bacterial toxins into the bloodstream and the development of systemic inflammation, provokes apoptosis of vascular smooth muscle cells, as well as endothelial dysfunction, which directly contributes to the development of cardiovascular complications. The indirect effects of increased urea levels are associated with carbamylation reactions, when isocyanic acid (a product of urea catabolism) changes the structure and function of proteins in the body. Carbamylation of proteins in CKD patients is associated with the development of renal fibrosis, atherosclerosis and anemia. Thus, urea is now regarded as an important negative agent in the pathogenesis of complications in CKD. Studies on a low-protein diet with using ketoanalogues of essential amino acids to minimize the accumulation of urea and other uremic toxins demonstrate the clinical benefit of such an intervention in slowing the progression of CKD and the development of cardiovascular complications.
OUTPUT:
|
PubMed_Summ19767 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Pre-messenger RNA splicing is initiated with the recognition of a single-nucleotide intronic branchpoint (BP) within a BP motif by spliceosome elements. Forty-eight rare variants in 43 human genes have been reported to alter splicing and cause disease by disrupting BP. However, until now, no computational approach was available to efficiently detect such variants in massively parallel sequencing data. We established a comprehensive human genome-wide BP database by integrating existing BP data and generating new BP data from RNA sequencing of lariat debranching enzyme DBR1-mutated patients and from machine-learning predictions. We characterized multiple features of BP in major and minor introns and found that BP and BP-2 (two nucleotides upstream of BP) positions exhibit a lower rate of variation in human populations and higher evolutionary conservation than the intronic background, while being comparable to the exonic background. We developed BPHunter as a genome-wide computational approach to systematically and efficiently detect intronic variants that may disrupt BP recognition. BPHunter retrospectively identified 40 of the 48 known pathogenic BP variants, in which we summarized a strategy for prioritizing BP variant candidates. The remaining eight variants all create AG-dinucleotides between the BP and acceptor site, which is the likely reason for missplicing. We demonstrated the practical utility of BPHunter prospectively by using it to identify a novel germline heterozygous BP variant of \n OUTPUT:\n "
},
{
"from": "agent",
"value": "Genome-wide detection of human variants that disrupt intronic branchpoints."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Pre-messenger RNA splicing is initiated with the recognition of a single-nucleotide intronic branchpoint (BP) within a BP motif by spliceosome elements. Forty-eight rare variants in 43 human genes have been reported to alter splicing and cause disease by disrupting BP. However, until now, no computational approach was available to efficiently detect such variants in massively parallel sequencing data. We established a comprehensive human genome-wide BP database by integrating existing BP data and generating new BP data from RNA sequencing of lariat debranching enzyme DBR1-mutated patients and from machine-learning predictions. We characterized multiple features of BP in major and minor introns and found that BP and BP-2 (two nucleotides upstream of BP) positions exhibit a lower rate of variation in human populations and higher evolutionary conservation than the intronic background, while being comparable to the exonic background. We developed BPHunter as a genome-wide computational approach to systematically and efficiently detect intronic variants that may disrupt BP recognition. BPHunter retrospectively identified 40 of the 48 known pathogenic BP variants, in which we summarized a strategy for prioritizing BP variant candidates. The remaining eight variants all create AG-dinucleotides between the BP and acceptor site, which is the likely reason for missplicing. We demonstrated the practical utility of BPHunter prospectively by using it to identify a novel germline heterozygous BP variant of
OUTPUT:
|
PubMed_Summ4047 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Serotonin is considered to be the neurotransmitter that controls several types of behavior: aggressiveness, impulsivity, food selection, stimulation, sexual behavior, reaction to pain, and emotional manifestations. The aim of this study was to determine the serotonin values in 43 dogs, divided into three different experimental variants: (1) between two groups of medium (\n OUTPUT:\n "
},
{
"from": "agent",
"value": "The Variation of Serotonin Values in Dogs in Different Environmental Conditions."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Serotonin is considered to be the neurotransmitter that controls several types of behavior: aggressiveness, impulsivity, food selection, stimulation, sexual behavior, reaction to pain, and emotional manifestations. The aim of this study was to determine the serotonin values in 43 dogs, divided into three different experimental variants: (1) between two groups of medium (
OUTPUT:
|
PubMed_Summ9288 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Although studies have extensively discussed the effects of COVID-19 on global health behaviors, little is known about the extent of COVID-19 preventive behaviors and their negative effects on the working-age population of Bangkok, Thailand. Therefore, this study aimed to examine health-risk behaviors, COVID-19 preventive behaviors, and the impact of the COVID-19 pandemic among the Thai working-age population. An online cross-sectional survey was conducted among working-age adults through a self-administered questionnaire. Data were analyzed with descriptive statistics and stepwise multiple regression. Of the 313 Thai participants (227 females, 72.5%), 84.0% had high levels of health-risk behaviors for preventing COVID-19 infection, most respondents (89.1%) had high levels of knowledge about COVID-19, and most respondents (61.7%) had high levels of overall COVID-19 preventive behaviors. Stepwise multiple regression revealed that health-risk behaviors (β = 0.445), knowledge of COVID-19 (β = 0.148), gender (β = 0.145), and age (β = 0.133) were predictive of COVID-19 preventive behaviors. Additionally, most respondents (48.9%) had moderate overall effects from COVID-19. Based on our findings, these factors must be considered when implementing public policies to improve COVID-19 preventive behaviors among the currently employed working-age population. In addition, appropriate interventions must be established and evaluated for the pandemic's long-term effects.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Health-Risk Behaviors, COVID-19 Preventive Behaviors, and the Impact of the COVID-19 Pandemic on the Working-Age Population of Bangkok, Thailand."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Although studies have extensively discussed the effects of COVID-19 on global health behaviors, little is known about the extent of COVID-19 preventive behaviors and their negative effects on the working-age population of Bangkok, Thailand. Therefore, this study aimed to examine health-risk behaviors, COVID-19 preventive behaviors, and the impact of the COVID-19 pandemic among the Thai working-age population. An online cross-sectional survey was conducted among working-age adults through a self-administered questionnaire. Data were analyzed with descriptive statistics and stepwise multiple regression. Of the 313 Thai participants (227 females, 72.5%), 84.0% had high levels of health-risk behaviors for preventing COVID-19 infection, most respondents (89.1%) had high levels of knowledge about COVID-19, and most respondents (61.7%) had high levels of overall COVID-19 preventive behaviors. Stepwise multiple regression revealed that health-risk behaviors (β = 0.445), knowledge of COVID-19 (β = 0.148), gender (β = 0.145), and age (β = 0.133) were predictive of COVID-19 preventive behaviors. Additionally, most respondents (48.9%) had moderate overall effects from COVID-19. Based on our findings, these factors must be considered when implementing public policies to improve COVID-19 preventive behaviors among the currently employed working-age population. In addition, appropriate interventions must be established and evaluated for the pandemic's long-term effects.
OUTPUT:
|
PubMed_Summ19963 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Healthcare organisations have been redesigning care delivery models in an attempt to extend, expand and supplement the registered nurse workforce by including more unregulated healthcare workers, such as the assistant-in-nursing. As the number of assistants-in-nursing grows it is essential that nurses have the requisite skills and knowledge to effectively delegate and supervise this growing workforce.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Factors impacting delegation decision making by registered nurses to assistants in nursing in the acute care setting: A mixed method study."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Healthcare organisations have been redesigning care delivery models in an attempt to extend, expand and supplement the registered nurse workforce by including more unregulated healthcare workers, such as the assistant-in-nursing. As the number of assistants-in-nursing grows it is essential that nurses have the requisite skills and knowledge to effectively delegate and supervise this growing workforce.
OUTPUT:
|
PubMed_Summ10712 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: High-risk surgeries for patients with severe aortic stenosis (AS) are challenging for anesthesiologists and can result in hemodynamic deterioration and even mortality. We describe a case in which remimazolam was used to induce and maintain general anesthesia for a high-risk, noncardiac surgery accompanied by ongoing bleeding. An 86-year-old man with severe AS was scheduled to undergo proximal gastrectomy due to ongoing gastrointestinal bleeding and severe anemia. Remimazolam, a novel, ultra-short-acting benzodiazepine, was administered along with remifentanil for the induction and maintenance of general anesthesia. Throughout the anesthetic process, the patient's cardiac index and systemic vascular resistance were well preserved without any vasopressor support. Remimazolam seems to have possible effectiveness as a relatively safe agent for the induction and maintenance of general anesthesia in patients with severe AS who are undergoing high-risk, noncardiac surgery with bleeding.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Remimazolam for General Anesthesia in a Patient with Severe Aortic Stenosis Undergoing High-Risk Surgery: A Case Report."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: High-risk surgeries for patients with severe aortic stenosis (AS) are challenging for anesthesiologists and can result in hemodynamic deterioration and even mortality. We describe a case in which remimazolam was used to induce and maintain general anesthesia for a high-risk, noncardiac surgery accompanied by ongoing bleeding. An 86-year-old man with severe AS was scheduled to undergo proximal gastrectomy due to ongoing gastrointestinal bleeding and severe anemia. Remimazolam, a novel, ultra-short-acting benzodiazepine, was administered along with remifentanil for the induction and maintenance of general anesthesia. Throughout the anesthetic process, the patient's cardiac index and systemic vascular resistance were well preserved without any vasopressor support. Remimazolam seems to have possible effectiveness as a relatively safe agent for the induction and maintenance of general anesthesia in patients with severe AS who are undergoing high-risk, noncardiac surgery with bleeding.
OUTPUT:
|
PubMed_Summ1574 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Infectious bursal disease (IBD) is an immunosuppressive and economically important disease of young chickens caused by infectious bursal disease virus (IBDV). The National Veterinary Institute (Bishoftu, Ethiopia) produces intermediate IBDV vaccine using primary chicken embryo fibroblast (CEF) cells, a method with technical and economical cumbersome. This study assessed the safety, immunogenicity, and efficacy of DF-1 cell line-adapted IBDV LC-75 vaccine strain in reference to the CEF-based vaccine. Confluent monolayer of DF-1 cells was infected with IBDV and cells with cytopathic effects were passaged until 3\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Comparative Safety, Immunogenicity, and Efficacy of CEF Cell-Based and DF-1 Cell Line Adapted Infectious Bursal Disease Vaccines in Specific-Pathogen-Free Chickens."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Infectious bursal disease (IBD) is an immunosuppressive and economically important disease of young chickens caused by infectious bursal disease virus (IBDV). The National Veterinary Institute (Bishoftu, Ethiopia) produces intermediate IBDV vaccine using primary chicken embryo fibroblast (CEF) cells, a method with technical and economical cumbersome. This study assessed the safety, immunogenicity, and efficacy of DF-1 cell line-adapted IBDV LC-75 vaccine strain in reference to the CEF-based vaccine. Confluent monolayer of DF-1 cells was infected with IBDV and cells with cytopathic effects were passaged until 3
OUTPUT:
|
PubMed_Summ20542 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Pediatric nurses are at high risk for burnout, resulting in unsatisfactory care quality. Although job resources like social support can prevent the development of burnout under work stress, the mediating role of personal resources like occupational commitment is not well studied. This study was to examine the mediating role of occupational commitment in the relationship between work stress and burnout, and test if the effect of work stress on occupational commitment varies at different levels of social support among pediatric nurses.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Work stress, burnout, occupational commitment, and social support among Chinese pediatric nurses: A moderated mediation model."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Pediatric nurses are at high risk for burnout, resulting in unsatisfactory care quality. Although job resources like social support can prevent the development of burnout under work stress, the mediating role of personal resources like occupational commitment is not well studied. This study was to examine the mediating role of occupational commitment in the relationship between work stress and burnout, and test if the effect of work stress on occupational commitment varies at different levels of social support among pediatric nurses.
OUTPUT:
|
PubMed_Summ5489 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Eosinophils are a major driver of inflammation in a number of human diseases, including asthma. Biologic therapies targeting IL-5 have enabled better control of severe eosinophilic asthma, but no such advances have been made for enhancing the control of moderate asthma. However, a number of moderate asthma sufferers remain troubled by unresolved symptoms, treatment side effects, or both. OmeGo, an enzymatically liberated fish oil, has demonstrated antioxidant and anti-inflammatory properties including the reduction of eosinophilia. A house dust mite model of induced asthma in mice was utilized in this study, and OmeGo showed a significant reduction in eosinophilic lung and systemic inflammation and reduced lung remodelling compared to cod liver oil. The CRTH2 antagonist fevipiprant showed an anti-inflammatory profile similar to that of OmeGo. OmeGo has the potential to be a pragmatic, cost-effective co-treatment for less severe forms of eosinophilic asthma. Proof-of-concept studies are planned.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Assessing the Anti-Inflammatory Effects of an Orally Dosed Enzymatically Liberated Fish Oil in a House Dust Model of Allergic Asthma."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Eosinophils are a major driver of inflammation in a number of human diseases, including asthma. Biologic therapies targeting IL-5 have enabled better control of severe eosinophilic asthma, but no such advances have been made for enhancing the control of moderate asthma. However, a number of moderate asthma sufferers remain troubled by unresolved symptoms, treatment side effects, or both. OmeGo, an enzymatically liberated fish oil, has demonstrated antioxidant and anti-inflammatory properties including the reduction of eosinophilia. A house dust mite model of induced asthma in mice was utilized in this study, and OmeGo showed a significant reduction in eosinophilic lung and systemic inflammation and reduced lung remodelling compared to cod liver oil. The CRTH2 antagonist fevipiprant showed an anti-inflammatory profile similar to that of OmeGo. OmeGo has the potential to be a pragmatic, cost-effective co-treatment for less severe forms of eosinophilic asthma. Proof-of-concept studies are planned.
OUTPUT:
|
PubMed_Summ11025 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: A semiconductor bridge (SCB) is an ignition device that provides a safe and efficient method widely used in civilian and military fields. The heating process of an SCB under electrical stimulation has a wide range of applications owing to its unique energy release process. However, the temperature variation of an SCB is challenging to obtain, both experimentally because of the rapid reaction on a microscale and with simulation due to its high demand in nonlinear calculations. In this study, we propose deep learning (DL) approach to study the electrothermal-coupled multi-physical heating process of the SCB initiator. We generated training data with multi-physics simulation (MPS), producing surface temperature distributions of SCBs under different voltages. The model was then trained with partial data in this database and evaluated on a separate test set. A generative adversarial network (GAN) with a customized loss function was used for modeling point-wise temperature dynamics. In the test set, our proposed method can predict the temperature distribution of an SCB under different voltages with high accuracy of over 0.9 during the heating process. We reduced the computation time by several orders of magnitude by replacing MPS with a deep neural network.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Modeling the Heating Dynamics of a Semiconductor Bridge Initiator with Deep Neural Network."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: A semiconductor bridge (SCB) is an ignition device that provides a safe and efficient method widely used in civilian and military fields. The heating process of an SCB under electrical stimulation has a wide range of applications owing to its unique energy release process. However, the temperature variation of an SCB is challenging to obtain, both experimentally because of the rapid reaction on a microscale and with simulation due to its high demand in nonlinear calculations. In this study, we propose deep learning (DL) approach to study the electrothermal-coupled multi-physical heating process of the SCB initiator. We generated training data with multi-physics simulation (MPS), producing surface temperature distributions of SCBs under different voltages. The model was then trained with partial data in this database and evaluated on a separate test set. A generative adversarial network (GAN) with a customized loss function was used for modeling point-wise temperature dynamics. In the test set, our proposed method can predict the temperature distribution of an SCB under different voltages with high accuracy of over 0.9 during the heating process. We reduced the computation time by several orders of magnitude by replacing MPS with a deep neural network.
OUTPUT:
|
PubMed_Summ15697 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The objective of this systematic review is to compare the diagnostic value of endolymphatic hydrops (EH) magnetic resonance imaging (MRI) with audiovestibular function tests, including electro cochleography (ECochG), cervical vestibular evoked myogenic potential (cVEMP) and caloric tests for the diagnosis of definite Meniere's disease (DMD). An electronic search was performed in the PubMed, Embase and Cochrane databases in August 2022. Original studies which reported the efficacy of gadolinium MRI for diagnosis of DMD were compared with ECochG, cVEMP and caloric tests from 2007 to 2022 published in English. Two reviewers extracted the methodology and results of MRI and functional tests, assessing them independently. A modified version of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was used for the assessment of the quality and the risk of bias of each study. The proportion of DMD cases diagnosed by MRI hydrops vs corresponding functional tests were calculated and the relationship between MRI and functional tests were evaluated using the Cohen's Kappa test. Concerning the MRI, the proportion diagnostic of DMD was 0.67 by cochlear EH and 0.80-0.82 by vestibular EH. Regarding the functional test, the propotiojn diagnostic of DMD was 0.48 by ECochG, 0.76 by cVEMP and 0.65 by caloric test. The findings of this systematic review were that the vestibular EH on imaging most effectively assisted in diagnosing DMD. Among the functional tests, cVEMP was the second most effective test. The agreement between imaging and cVEMP was moderate (0.44), indicating a gap between the patients identified by the imaging and functional tests based on the relatively small number of patients.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Systematic review of the diagnostic value of hydrops MRI in relation to audiovestibular function tests (electrocochleography, cervical vestibular evoked myogenic potential and caloric test)."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The objective of this systematic review is to compare the diagnostic value of endolymphatic hydrops (EH) magnetic resonance imaging (MRI) with audiovestibular function tests, including electro cochleography (ECochG), cervical vestibular evoked myogenic potential (cVEMP) and caloric tests for the diagnosis of definite Meniere's disease (DMD). An electronic search was performed in the PubMed, Embase and Cochrane databases in August 2022. Original studies which reported the efficacy of gadolinium MRI for diagnosis of DMD were compared with ECochG, cVEMP and caloric tests from 2007 to 2022 published in English. Two reviewers extracted the methodology and results of MRI and functional tests, assessing them independently. A modified version of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was used for the assessment of the quality and the risk of bias of each study. The proportion of DMD cases diagnosed by MRI hydrops vs corresponding functional tests were calculated and the relationship between MRI and functional tests were evaluated using the Cohen's Kappa test. Concerning the MRI, the proportion diagnostic of DMD was 0.67 by cochlear EH and 0.80-0.82 by vestibular EH. Regarding the functional test, the propotiojn diagnostic of DMD was 0.48 by ECochG, 0.76 by cVEMP and 0.65 by caloric test. The findings of this systematic review were that the vestibular EH on imaging most effectively assisted in diagnosing DMD. Among the functional tests, cVEMP was the second most effective test. The agreement between imaging and cVEMP was moderate (0.44), indicating a gap between the patients identified by the imaging and functional tests based on the relatively small number of patients.
OUTPUT:
|
PubMed_Summ17303 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Microplastics (MPs) are considered to influence the bioavailability of heavy metals through direct adsorption, but this neglects the distribution of heavy metal chemical speciation indirectly influenced by MPs by altering geochemical properties. The present study aims to explore the link between the fractionation distribution of cadmium (Cd\n OUTPUT:\n "
},
{
"from": "agent",
"value": "New insights into the decrease in Cd"
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Microplastics (MPs) are considered to influence the bioavailability of heavy metals through direct adsorption, but this neglects the distribution of heavy metal chemical speciation indirectly influenced by MPs by altering geochemical properties. The present study aims to explore the link between the fractionation distribution of cadmium (Cd
OUTPUT:
|
PubMed_Summ17921 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Hypernatremia (serum sodium>160 meq/L) present with diverse neurological manifestations, ranging from flaccid paralysis to impaired cognition, encephalopathy, and even deep coma. Osmotic demyelination refers to changes in brain cells because of an acute change in plasma osmolality. It is further divided into two types, i.e., central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM). Patients with EPM, besides spasticity, may also present with other movement disorders such as catatonia, parkinsonism, and dystonia. We present a case of a postpartum woman bought to the emergency department by her relatives in an unconscious state. In view of poor sensorium (Glasgow coma scale < 7), she was intubated and received mechanical ventilatory support. On admission, computed tomography ofthebrain was normal, and the patient was transferred to the intensive care unit (ICU) for further management. The preliminary work-up in the ICU showed hypernatremia (serum sodium of 182 mEq/L) with hyper-osmolality (359 mOsm/kgH\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Postpartum Hypernatremia with Extrapontine Rhabdomyelinolysis: A Case Report."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Hypernatremia (serum sodium>160 meq/L) present with diverse neurological manifestations, ranging from flaccid paralysis to impaired cognition, encephalopathy, and even deep coma. Osmotic demyelination refers to changes in brain cells because of an acute change in plasma osmolality. It is further divided into two types, i.e., central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM). Patients with EPM, besides spasticity, may also present with other movement disorders such as catatonia, parkinsonism, and dystonia. We present a case of a postpartum woman bought to the emergency department by her relatives in an unconscious state. In view of poor sensorium (Glasgow coma scale < 7), she was intubated and received mechanical ventilatory support. On admission, computed tomography ofthebrain was normal, and the patient was transferred to the intensive care unit (ICU) for further management. The preliminary work-up in the ICU showed hypernatremia (serum sodium of 182 mEq/L) with hyper-osmolality (359 mOsm/kgH
OUTPUT:
|
PubMed_Summ24889 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In this paper, a mathematical model with a standard incidence rate is proposed to assess the role of media such as facebook, television, radio and tweeter in the mitigation of the outbreak of COVID-19. The basic reproduction number \n OUTPUT:\n "
},
{
"from": "agent",
"value": "Mathematical analysis of the impact of the media coverage in mitigating the outbreak of COVID-19."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: In this paper, a mathematical model with a standard incidence rate is proposed to assess the role of media such as facebook, television, radio and tweeter in the mitigation of the outbreak of COVID-19. The basic reproduction number
OUTPUT:
|
PubMed_Summ16650 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Pulmonary arterial hypertension (PAH) is a rare disease, which can be caused by (likely) pathogenic germline genomic variants. In addition to the most prevalent disease gene, termed \n OUTPUT:\n "
},
{
"from": "agent",
"value": "Genetic counselling and testing in pulmonary arterial hypertension -A consensus statement on behalf of the International Consortium for Genetic Studies in PAH."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Pulmonary arterial hypertension (PAH) is a rare disease, which can be caused by (likely) pathogenic germline genomic variants. In addition to the most prevalent disease gene, termed
OUTPUT:
|
PubMed_Summ25291 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Nest materials are a major heat source due to rotting promoted by microbial activity. Additionally, they are a potential microbial source given their direct contact with eggshells. Microbial dynamics during incubation have been studied in wild birds; however, similar studies in reptiles remain elusive. Here, the study characterized microbial communities in the nest materials of Chinese alligator (\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Incubation determines favorable microbial communities in Chinese alligator nests."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Nest materials are a major heat source due to rotting promoted by microbial activity. Additionally, they are a potential microbial source given their direct contact with eggshells. Microbial dynamics during incubation have been studied in wild birds; however, similar studies in reptiles remain elusive. Here, the study characterized microbial communities in the nest materials of Chinese alligator (
OUTPUT:
|
PubMed_Summ8006 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: We propose a novel effective framework for the analysis of the shared genetic background for a set of genetically correlated traits using SNP-level GWAS summary statistics. This framework called SHAHER is based on the construction of a linear combination of traits by maximizing the proportion of its genetic variance explained by the shared genetic factors. SHAHER requires only full GWAS summary statistics and matrices of genetic and phenotypic correlations between traits as inputs. Our framework allows both shared and unshared genetic factors to be effectively analyzed. We tested our framework using simulation studies, compared it with previous developments, and assessed its performance using three real datasets: anthropometric traits, psychiatric conditions and lipid concentrations. SHAHER is versatile and applicable to summary statistics from GWASs with arbitrary sample sizes and sample overlaps, allows for the incorporation of different GWAS models (Cox, linear and logistic), and is computationally fast.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "A Novel Framework for Analysis of the Shared Genetic Background of Correlated Traits."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: We propose a novel effective framework for the analysis of the shared genetic background for a set of genetically correlated traits using SNP-level GWAS summary statistics. This framework called SHAHER is based on the construction of a linear combination of traits by maximizing the proportion of its genetic variance explained by the shared genetic factors. SHAHER requires only full GWAS summary statistics and matrices of genetic and phenotypic correlations between traits as inputs. Our framework allows both shared and unshared genetic factors to be effectively analyzed. We tested our framework using simulation studies, compared it with previous developments, and assessed its performance using three real datasets: anthropometric traits, psychiatric conditions and lipid concentrations. SHAHER is versatile and applicable to summary statistics from GWASs with arbitrary sample sizes and sample overlaps, allows for the incorporation of different GWAS models (Cox, linear and logistic), and is computationally fast.
OUTPUT:
|
PubMed_Summ17015 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Kinetics of the reaction of IO radicals with methanol (MeOH) and ethanol (EtOH) were experimentally studied in the gas phase using pulsed laser photolysis-cavity ring-down spectroscopy (PLP-CRDS). IO radicals were produced in situ at the reaction zone by photolysing a mixture of precursors (CH\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Kinetics of IO radicals with C1, C2 aliphatic alcohols in tropospherically relevant conditions."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Kinetics of the reaction of IO radicals with methanol (MeOH) and ethanol (EtOH) were experimentally studied in the gas phase using pulsed laser photolysis-cavity ring-down spectroscopy (PLP-CRDS). IO radicals were produced in situ at the reaction zone by photolysing a mixture of precursors (CH
OUTPUT:
|
PubMed_Summ9055 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Eleven world elite ski-mountaineering (Ski-Mo) athletes were evaluated for pronounced echocardiographic physiological remodeling as the primary aim of our feasibility speckle tracking study. In this context, sports-related cardiac remodeling was analyzed by performing two-dimensional echocardiography, including speckle tracking analysis of the left atrium (LA), right ventricle (RV) and left ventricular (LV) global longitudinal strain (LV-GLS) at rest and post-peak performance. The feasibility echocardiographic speckle tracking analysis was performed on eleven elite Ski-Mo athletes, which were obtained in 2022 during the annual medical examination. The obtained data of the professional Ski-Mo athletes (11 athletes, age: 18-26 years) were compared for different echocardiographic parameters at rest and post-exercise. Significant differences were found for LV-GLS mean (\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Left Ventricular, Left Atrial and Right Ventricular Strain Modifications after Maximal Exercise in Elite Ski-Mountaineering Athletes: A Feasibility Speckle Tracking Study."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Eleven world elite ski-mountaineering (Ski-Mo) athletes were evaluated for pronounced echocardiographic physiological remodeling as the primary aim of our feasibility speckle tracking study. In this context, sports-related cardiac remodeling was analyzed by performing two-dimensional echocardiography, including speckle tracking analysis of the left atrium (LA), right ventricle (RV) and left ventricular (LV) global longitudinal strain (LV-GLS) at rest and post-peak performance. The feasibility echocardiographic speckle tracking analysis was performed on eleven elite Ski-Mo athletes, which were obtained in 2022 during the annual medical examination. The obtained data of the professional Ski-Mo athletes (11 athletes, age: 18-26 years) were compared for different echocardiographic parameters at rest and post-exercise. Significant differences were found for LV-GLS mean (
OUTPUT:
|
PubMed_Summ22160 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study assessed the incidence of meniscal tears in ACL deficient knees considering the time between injury and reconstruction in a large sample of female patients. Furthermore, we evaluated whether the rate of meniscal repair or meniscectomy was affected by age and BMI.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Increased time to Surgery after ACL Tear in Females results in Greater Risk of Medial Meniscus Tear."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: This study assessed the incidence of meniscal tears in ACL deficient knees considering the time between injury and reconstruction in a large sample of female patients. Furthermore, we evaluated whether the rate of meniscal repair or meniscectomy was affected by age and BMI.
OUTPUT:
|
PubMed_Summ4964 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Microsaccades play a critical role in refreshing visual information and have been shown to have direction-specific influences on human perception. However, the neural mechanisms underlying such direction-specific effects remains unknown. Here, we report the emergence of direction-specific microsaccade modulation in the middle layer of V2 but not in V1: responses of V2 neurons after microsaccades moved toward their receptive fields were stronger than those when microsaccades moved away. The decreased responses from V1 to V2, which are correlated with the amplitude of microsaccades away from receptive fields, suggest topographically location-specific suppression from an oculomotor source. Consistent with directional effects in V2, microsaccades function as a guide for monkeys' behavior in a peripheral detection task; both can be explained by a dynamic neural network. Our findings suggest a V1-bypassing suppressive circuit for direction-specific microsaccade modulation in V2 and its functional influence on visual sensitivity, which highlights the optimal sampling nature of microsaccades.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "V1-bypassing suppression leads to direction-specific microsaccade modulation in visual coding and perception."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Microsaccades play a critical role in refreshing visual information and have been shown to have direction-specific influences on human perception. However, the neural mechanisms underlying such direction-specific effects remains unknown. Here, we report the emergence of direction-specific microsaccade modulation in the middle layer of V2 but not in V1: responses of V2 neurons after microsaccades moved toward their receptive fields were stronger than those when microsaccades moved away. The decreased responses from V1 to V2, which are correlated with the amplitude of microsaccades away from receptive fields, suggest topographically location-specific suppression from an oculomotor source. Consistent with directional effects in V2, microsaccades function as a guide for monkeys' behavior in a peripheral detection task; both can be explained by a dynamic neural network. Our findings suggest a V1-bypassing suppressive circuit for direction-specific microsaccade modulation in V2 and its functional influence on visual sensitivity, which highlights the optimal sampling nature of microsaccades.
OUTPUT:
|
PubMed_Summ17180 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The aim of this study was to investigate the relationships between hypoglycemia, hyperglycemia, glycemic variability (GV), and eating behavior by measuring daily glucose levels through an intermittently scanned continuous glucose monitoring (isCGM) system in outpatients classified according to eating disorder subtypes.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Continuous glucose monitoring for detection of glycemic variability, hypoglycemia, and hyperglycemia in women with eating disorders."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The aim of this study was to investigate the relationships between hypoglycemia, hyperglycemia, glycemic variability (GV), and eating behavior by measuring daily glucose levels through an intermittently scanned continuous glucose monitoring (isCGM) system in outpatients classified according to eating disorder subtypes.
OUTPUT:
|
PubMed_Summ12889 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The advancement of autonomous driving technology has had a significant impact on both transportation networks and people's lives. Connected and automated vehicles as well as the surrounding driving environment are increasingly exchanging information. The traditional open road test or closed field test, which has large costs, lengthy durations, and few diverse test scenarios, cannot satisfy the autonomous driving system's need for reliable and safe testing. Functional testing is the emphasis of the test since features such as frontal collision and traffic sign warning influence driving safety. As a result, simulation testing will undoubtedly emerge as a new technique for unmanned vehicle testing. A crucial aspect of simulation testing is the creation of test scenarios. With an emphasis on the map generating method and the dynamic scenario production method in the test scenarios, this article explains many scenarios and scenario construction techniques utilized in the process of self-driving car testing. A thorough analysis of the state of relevant research is conducted, and approaches for creating common scenarios as well as brand-new methods based on machine learning are emphasized.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Review on Functional Testing Scenario Library Generation for Connected and Automated Vehicles."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The advancement of autonomous driving technology has had a significant impact on both transportation networks and people's lives. Connected and automated vehicles as well as the surrounding driving environment are increasingly exchanging information. The traditional open road test or closed field test, which has large costs, lengthy durations, and few diverse test scenarios, cannot satisfy the autonomous driving system's need for reliable and safe testing. Functional testing is the emphasis of the test since features such as frontal collision and traffic sign warning influence driving safety. As a result, simulation testing will undoubtedly emerge as a new technique for unmanned vehicle testing. A crucial aspect of simulation testing is the creation of test scenarios. With an emphasis on the map generating method and the dynamic scenario production method in the test scenarios, this article explains many scenarios and scenario construction techniques utilized in the process of self-driving car testing. A thorough analysis of the state of relevant research is conducted, and approaches for creating common scenarios as well as brand-new methods based on machine learning are emphasized.
OUTPUT:
|
PubMed_Summ4069 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: (1) Background: colic syndrome is a multifactorial life-threatening condition in equids. Awareness of predisposing and prognostic indicators is useful to adequately inform the owner of the outcome and plan the best treatment. The aim of the study was to identify the variables associated with short-term survival in a cohort of horses referred for colic to a veterinary teaching hospital; (2) Methods: medical records of horses referred for colic from 2016 to 2022 were retrospectively reviewed. Univariate and multivariate regression models were built to assess the odds ratios of discharge from the hospital, both on the whole sample and in those patients undergoing surgery; (3) Conclusions: Month, time of admission, cardiovascular variables (heart rate on admission and after 3-6 h, packed cell volume, capillary refill time, and mucosal membranes), and presence of gastric reflux were significantly associated with discharge in the univariate regression in all horses and in those surgically treated. In the multivariate regression model, heart rate, packed cell volume, and capillary refill time showed significant association with the outcome in the whole sample. Although comparison between this study and previous studies is difficult due to the number and type of variables included, cardiovascular variables and markers of hypovolemia were also shown to be associated with outcome.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Retrospective Study on Risk Factors and Short-Term Outcome of Horses Referred for Colic from 2016 to 2022."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: (1) Background: colic syndrome is a multifactorial life-threatening condition in equids. Awareness of predisposing and prognostic indicators is useful to adequately inform the owner of the outcome and plan the best treatment. The aim of the study was to identify the variables associated with short-term survival in a cohort of horses referred for colic to a veterinary teaching hospital; (2) Methods: medical records of horses referred for colic from 2016 to 2022 were retrospectively reviewed. Univariate and multivariate regression models were built to assess the odds ratios of discharge from the hospital, both on the whole sample and in those patients undergoing surgery; (3) Conclusions: Month, time of admission, cardiovascular variables (heart rate on admission and after 3-6 h, packed cell volume, capillary refill time, and mucosal membranes), and presence of gastric reflux were significantly associated with discharge in the univariate regression in all horses and in those surgically treated. In the multivariate regression model, heart rate, packed cell volume, and capillary refill time showed significant association with the outcome in the whole sample. Although comparison between this study and previous studies is difficult due to the number and type of variables included, cardiovascular variables and markers of hypovolemia were also shown to be associated with outcome.
OUTPUT:
|
PubMed_Summ23999 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Family resilience is frequently recognized as a powerful determinant of family adaptation in chronic disease patients; understanding the family resilience of stroke patients and its predictors could help nurses develop interventions to assist patients in maintaining healthy family functioning.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Family resilience of stroke survivors within 6 months after a first-episode stroke: A longitudinal study."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Family resilience is frequently recognized as a powerful determinant of family adaptation in chronic disease patients; understanding the family resilience of stroke patients and its predictors could help nurses develop interventions to assist patients in maintaining healthy family functioning.
OUTPUT:
|
PubMed_Summ14330 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study examines the distribution and development of intraocular pressure (IOP) in infants aged from 0 to 36 months and analyzes its correlation with corneal diameter.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Changes to intraocular pressure and its correlation with corneal diameter in infants aged from 0 to 36 months."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: This study examines the distribution and development of intraocular pressure (IOP) in infants aged from 0 to 36 months and analyzes its correlation with corneal diameter.
OUTPUT:
|
PubMed_Summ15445 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Myocardial ischemia-reperfusion injury (MIRI) caused by the reperfusion therapy of myocardial ischemic diseases is a kind of major disease that threatens human health and lives severely. There are lacking of effective therapeutic measures for MIRI. MicroRNAs (miRNAs) are abundant in mammalian species and play a critical role in the initiation, promotion, and progression of MIRI. However, the biological role and molecular mechanism of miRNAs in MIRI are not entirely clear.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "MicroRNA-582-5p targeting Creb1 modulates apoptosis in cardiomyocytes hypoxia/reperfusion-induced injury."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Myocardial ischemia-reperfusion injury (MIRI) caused by the reperfusion therapy of myocardial ischemic diseases is a kind of major disease that threatens human health and lives severely. There are lacking of effective therapeutic measures for MIRI. MicroRNAs (miRNAs) are abundant in mammalian species and play a critical role in the initiation, promotion, and progression of MIRI. However, the biological role and molecular mechanism of miRNAs in MIRI are not entirely clear.
OUTPUT:
|
PubMed_Summ23857 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The problem of accurate, fast, and inexpensive COVID-19 tests has been urgent till now. Standard COVID-19 tests need high-cost reagents and specialized laboratories with high safety requirements, are time-consuming. Data of routine blood tests as a base of SARS-CoV-2 invasion detection allows using the most practical medicine facilities. But blood tests give general information about a patient's state, which is not directly associated with COVID-19. COVID-19-specific features should be selected from the list of standard blood characteristics, and decision-making software based on appropriate clinical data should be created. This review describes the abilities to develop predictive models for COVID-19 detection using routine blood tests and machine learning.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Predictive models for COVID-19 detection using routine blood tests and machine learning."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The problem of accurate, fast, and inexpensive COVID-19 tests has been urgent till now. Standard COVID-19 tests need high-cost reagents and specialized laboratories with high safety requirements, are time-consuming. Data of routine blood tests as a base of SARS-CoV-2 invasion detection allows using the most practical medicine facilities. But blood tests give general information about a patient's state, which is not directly associated with COVID-19. COVID-19-specific features should be selected from the list of standard blood characteristics, and decision-making software based on appropriate clinical data should be created. This review describes the abilities to develop predictive models for COVID-19 detection using routine blood tests and machine learning.
OUTPUT:
|
PubMed_Summ24891 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The purpose of this study was to evaluate, revise, and extend the Informed Consent Ontology (ICO) for expressing clinical permissions, including reuse of residual clinical biospecimens and health data. This study followed a formative evaluation design and used a bottom-up modeling approach. Data were collected from the literature on US federal regulations and a study of clinical consent forms. Eleven federal regulations and fifteen permission-sentences from clinical consent forms were iteratively modeled to identify entities and their relationships, followed by community reflection and negotiation based on a series of predetermined evaluation questions. ICO included fifty-two classes and twelve object properties necessary when modeling, demonstrating appropriateness of extending ICO for the clinical domain. Twenty-six additional classes were imported into ICO from other ontologies, and twelve new classes were recommended for development. This work addresses a critical gap in formally representing permissions clinical permissions, including reuse of residual clinical biospecimens and health data. It makes missing content available to the OBO Foundry, enabling use alongside other widely-adopted biomedical ontologies. ICO serves as a machine-interpretable and interoperable tool for responsible reuse of residual clinical biospecimens and health data at scale.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Evaluating and Extending the Informed Consent Ontology for Representing Permissions from the Clinical Domain."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The purpose of this study was to evaluate, revise, and extend the Informed Consent Ontology (ICO) for expressing clinical permissions, including reuse of residual clinical biospecimens and health data. This study followed a formative evaluation design and used a bottom-up modeling approach. Data were collected from the literature on US federal regulations and a study of clinical consent forms. Eleven federal regulations and fifteen permission-sentences from clinical consent forms were iteratively modeled to identify entities and their relationships, followed by community reflection and negotiation based on a series of predetermined evaluation questions. ICO included fifty-two classes and twelve object properties necessary when modeling, demonstrating appropriateness of extending ICO for the clinical domain. Twenty-six additional classes were imported into ICO from other ontologies, and twelve new classes were recommended for development. This work addresses a critical gap in formally representing permissions clinical permissions, including reuse of residual clinical biospecimens and health data. It makes missing content available to the OBO Foundry, enabling use alongside other widely-adopted biomedical ontologies. ICO serves as a machine-interpretable and interoperable tool for responsible reuse of residual clinical biospecimens and health data at scale.
OUTPUT:
|
PubMed_Summ12541 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Bilberry fruits (\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Ultrasound-Assisted Natural Deep Eutectic Solvents Extraction of Bilberry Anthocyanins: Optimization, Bioactivities, and Storage Stability."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Bilberry fruits (
OUTPUT:
|
PubMed_Summ2542 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Inbreeding depression in closed populations impairs animal fitness, health, and productivity. However, not all inbreeding is expected to be equally damaging. Recent inbreeding is thought to be more harmful than ancient inbreeding because selection decreases the frequency of unfavourable alleles with time. Accordingly, selection efficiency is improved by inbreeding in a process called purging. This research aimed to quantify inbreeding depression on growth and prolificacy traits in two lines of rabbits selected for just one growth (Caldes line) or prolificacy (Prat line) trait, and also to find some evidence of purging of deleterious alleles by selection. Caldes line comprised 51 generations and 124,371 animals in the pedigree. Prat line comprised 34 generations and 161,039 animals in the pedigree. The effects of old, intermediate, and new inbreeding (Fold, Fint, and Fnew), as well as total cumulated classical inbreeding (F) and 3 measurements of ancestral inbreeding (AHC, Fa.K, and Fa.B) were estimated for average daily gain (ADG), slaughter weight (SW), weaning weight (WW), born alive (BA), the total number of kits (NT), and the number of weaned kits (NW). There was a clear inbreeding depression for all growth and prolificacy traits in the Caldes line (-7.19 g/d, -0.45 kg, -0.25 kg, -6 kits, -4 kits, and -4 kits per unit of increase in F for ADG, SW, WW, BA, NT, and NW, respectively) and also in Prat line (-7.48 g/d, -0.31 kg, -0.11 kg, -4 kits, -5 kits, and -4 kits per unit of increase in F for ADG, SW, WW, BA, NT, and NW, respectively). The inbreeding partition appears to be a reliable alternative for assessing inbreeding depression and purging. Thus, for example, in the Caldes line and for ADG the regression coefficients were -7.61, -5.41, and 7.76 g/d per unit of increase in Fnew, Fint, and Fold, respectively. In addition, AHC and Fa.B may provide more accurate evidence of purging than Fa.K. This study confirms the existence of inbreeding depression for growth and prolificacy traits in both lines of rabbits and shows evidence of purging of deleterious recessive alleles involved both in growth and prolificacy, independently of the selection criteria established in the line.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Inbreeding depression on growth and prolificacy traits in two lines of rabbit."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Inbreeding depression in closed populations impairs animal fitness, health, and productivity. However, not all inbreeding is expected to be equally damaging. Recent inbreeding is thought to be more harmful than ancient inbreeding because selection decreases the frequency of unfavourable alleles with time. Accordingly, selection efficiency is improved by inbreeding in a process called purging. This research aimed to quantify inbreeding depression on growth and prolificacy traits in two lines of rabbits selected for just one growth (Caldes line) or prolificacy (Prat line) trait, and also to find some evidence of purging of deleterious alleles by selection. Caldes line comprised 51 generations and 124,371 animals in the pedigree. Prat line comprised 34 generations and 161,039 animals in the pedigree. The effects of old, intermediate, and new inbreeding (Fold, Fint, and Fnew), as well as total cumulated classical inbreeding (F) and 3 measurements of ancestral inbreeding (AHC, Fa.K, and Fa.B) were estimated for average daily gain (ADG), slaughter weight (SW), weaning weight (WW), born alive (BA), the total number of kits (NT), and the number of weaned kits (NW). There was a clear inbreeding depression for all growth and prolificacy traits in the Caldes line (-7.19 g/d, -0.45 kg, -0.25 kg, -6 kits, -4 kits, and -4 kits per unit of increase in F for ADG, SW, WW, BA, NT, and NW, respectively) and also in Prat line (-7.48 g/d, -0.31 kg, -0.11 kg, -4 kits, -5 kits, and -4 kits per unit of increase in F for ADG, SW, WW, BA, NT, and NW, respectively). The inbreeding partition appears to be a reliable alternative for assessing inbreeding depression and purging. Thus, for example, in the Caldes line and for ADG the regression coefficients were -7.61, -5.41, and 7.76 g/d per unit of increase in Fnew, Fint, and Fold, respectively. In addition, AHC and Fa.B may provide more accurate evidence of purging than Fa.K. This study confirms the existence of inbreeding depression for growth and prolificacy traits in both lines of rabbits and shows evidence of purging of deleterious recessive alleles involved both in growth and prolificacy, independently of the selection criteria established in the line.
OUTPUT:
|
PubMed_Summ21148 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The use of fluorescently tagged amyloid peptides, implicated in Alzheimer's disease, to study their aggregation at low concentrations is a common method; however, the fluorescent tag should not introduce a bias in the aggregation process. In this work, native amyloid peptides Aβ(1-40) and Aβ(1-42) and fluorescein-5-isothiocyanate (FITC), tagged ones, were studied using Taylor dispersion analysis coupled with a simultaneous UV and light-emitting diode-induced fluorescence detection, to unravel the effect of FITC on the aggregation process. For that, a total concentration of 100 µM of peptides consisting of a mixture of native and tagged ones (up to 10% in moles) was applied. Results demonstrated that FITC had a strong inhibition effect upon the aggregation behaviour of Aβ(1-42), whereas for Aβ(1-40), only a retardation in kinetics was observed. It was also shown that when mixed solutions of Aβ(1-40) and Aβ(1-42) are used, the Aβ(1-42) alloform was the leading peptide in the aggregation process, and when the latter was tagged, the aggregation kinetics decreased but the lifetime of potentially toxic oligomers was drastically increased. These results confirmed that the hydrophilicity of the N-terminus part of the peptide plays a major role in the aggregation process.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Taylor dispersion analysis discloses the impairment of Aβ peptide aggregation by the presence of a fluorescent tag."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The use of fluorescently tagged amyloid peptides, implicated in Alzheimer's disease, to study their aggregation at low concentrations is a common method; however, the fluorescent tag should not introduce a bias in the aggregation process. In this work, native amyloid peptides Aβ(1-40) and Aβ(1-42) and fluorescein-5-isothiocyanate (FITC), tagged ones, were studied using Taylor dispersion analysis coupled with a simultaneous UV and light-emitting diode-induced fluorescence detection, to unravel the effect of FITC on the aggregation process. For that, a total concentration of 100 µM of peptides consisting of a mixture of native and tagged ones (up to 10% in moles) was applied. Results demonstrated that FITC had a strong inhibition effect upon the aggregation behaviour of Aβ(1-42), whereas for Aβ(1-40), only a retardation in kinetics was observed. It was also shown that when mixed solutions of Aβ(1-40) and Aβ(1-42) are used, the Aβ(1-42) alloform was the leading peptide in the aggregation process, and when the latter was tagged, the aggregation kinetics decreased but the lifetime of potentially toxic oligomers was drastically increased. These results confirmed that the hydrophilicity of the N-terminus part of the peptide plays a major role in the aggregation process.
OUTPUT:
|
PubMed_Summ8468 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Chitin synthesis has attracted scientific interest for decades as an essential part of fungal biology and for its potential as a target for antifungal therapies. While this interest remains, three decades ago, pioneering molecular studies on chitin synthesis regulation identified the major chitin synthase in yeast, Chs3, as an authentic paradigm in the field of the intracellular trafficking of integral membrane proteins. Over the years, researchers have shown how the intracellular trafficking of Chs3 recapitulates all the steps in the intracellular trafficking of integral membrane proteins, from their synthesis in the endoplasmic reticulum to their degradation in the vacuole. This trafficking includes specific mechanisms for sorting in the \n OUTPUT:\n "
},
{
"from": "agent",
"value": "Chitin Synthesis in Yeast: A Matter of Trafficking."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Chitin synthesis has attracted scientific interest for decades as an essential part of fungal biology and for its potential as a target for antifungal therapies. While this interest remains, three decades ago, pioneering molecular studies on chitin synthesis regulation identified the major chitin synthase in yeast, Chs3, as an authentic paradigm in the field of the intracellular trafficking of integral membrane proteins. Over the years, researchers have shown how the intracellular trafficking of Chs3 recapitulates all the steps in the intracellular trafficking of integral membrane proteins, from their synthesis in the endoplasmic reticulum to their degradation in the vacuole. This trafficking includes specific mechanisms for sorting in the
OUTPUT:
|
PubMed_Summ14682 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Accurate classification and localization of abnormalities in chest X-rays play an important role in clinical diagnosis and treatment planning. Building a highly accurate predictive model for these tasks usually requires a large number of manually annotated labels and pixel regions (bounding boxes) of abnormalities. However, it is expensive to acquire such annotations, especially the bounding boxes. Recently, contrastive learning has shown strong promise in leveraging unlabeled natural images to produce highly generalizable and discriminative features. However, extending its power to the medical image domain is under-explored and highly non-trivial, since medical images are much less amendable to data augmentations. In contrast, their prior knowledge, as well as radiomic features, is often crucial. To bridge this gap, we propose an end-to-end semi-supervised knowledge-augmented contrastive learning framework, that simultaneously performs disease classification and localization tasks. The key knob of our framework is a unique positive sampling approach tailored for the medical images, by seamlessly integrating radiomic features as a knowledge augmentation. Specifically, we first apply an image encoder to classify the chest X-rays and to generate the image features. We next leverage Grad-CAM to highlight the crucial (abnormal) regions for chest X-rays (even when unannotated), from which we extract radiomic features. The radiomic features are then passed through another dedicated encoder to act as the positive sample for the image features generated from the same chest X-ray. In this way, our framework constitutes a feedback loop for image and radiomic features to mutually reinforce each other. Their contrasting yields knowledge-augmented representations that are both robust and interpretable. Extensive experiments on the NIH Chest X-ray dataset demonstrate that our approach outperforms existing baselines in both classification and localization tasks.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Knowledge-Augmented Contrastive Learning for Abnormality Classification and Localization in Chest X-rays with Radiomics using a Feedback Loop."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Accurate classification and localization of abnormalities in chest X-rays play an important role in clinical diagnosis and treatment planning. Building a highly accurate predictive model for these tasks usually requires a large number of manually annotated labels and pixel regions (bounding boxes) of abnormalities. However, it is expensive to acquire such annotations, especially the bounding boxes. Recently, contrastive learning has shown strong promise in leveraging unlabeled natural images to produce highly generalizable and discriminative features. However, extending its power to the medical image domain is under-explored and highly non-trivial, since medical images are much less amendable to data augmentations. In contrast, their prior knowledge, as well as radiomic features, is often crucial. To bridge this gap, we propose an end-to-end semi-supervised knowledge-augmented contrastive learning framework, that simultaneously performs disease classification and localization tasks. The key knob of our framework is a unique positive sampling approach tailored for the medical images, by seamlessly integrating radiomic features as a knowledge augmentation. Specifically, we first apply an image encoder to classify the chest X-rays and to generate the image features. We next leverage Grad-CAM to highlight the crucial (abnormal) regions for chest X-rays (even when unannotated), from which we extract radiomic features. The radiomic features are then passed through another dedicated encoder to act as the positive sample for the image features generated from the same chest X-ray. In this way, our framework constitutes a feedback loop for image and radiomic features to mutually reinforce each other. Their contrasting yields knowledge-augmented representations that are both robust and interpretable. Extensive experiments on the NIH Chest X-ray dataset demonstrate that our approach outperforms existing baselines in both classification and localization tasks.
OUTPUT:
|
PubMed_Summ15304 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To improve susceptibility tensor imaging (STI) reconstruction using the asymmetric STI model with the correction of non-bulk-magnetic-susceptibility (NBMS) effects.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "An improved asymmetric susceptibility tensor imaging model with frequency offset correction."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: To improve susceptibility tensor imaging (STI) reconstruction using the asymmetric STI model with the correction of non-bulk-magnetic-susceptibility (NBMS) effects.
OUTPUT:
|
PubMed_Summ13678 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Laser cavity-soliton microcombs are robust optical pulsed sources, usually implemented with a microresonator-filtered fibre laser. In such a configuration, a nonlinear microcavity converts the narrowband pulse resulting from bandwidth-limited amplification to a background-free broadband microcomb. Here, we theoretically and experimentally study the soliton conversion efficiency between the narrowband input pulse and the two outputs of a four-port integrated microcavity, namely the 'Drop' and 'Through' ports. We simultaneously measure on-chip, single-soliton conversion efficiencies of 45% and 25% for the two broadband comb outputs at the 'Drop' and 'Through' ports of a 48.9 GHz free-spectral range micro-ring resonator, obtaining a total conversion efficiency of 72%.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "High parametric efficiency in laser cavity-soliton microcombs."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Laser cavity-soliton microcombs are robust optical pulsed sources, usually implemented with a microresonator-filtered fibre laser. In such a configuration, a nonlinear microcavity converts the narrowband pulse resulting from bandwidth-limited amplification to a background-free broadband microcomb. Here, we theoretically and experimentally study the soliton conversion efficiency between the narrowband input pulse and the two outputs of a four-port integrated microcavity, namely the 'Drop' and 'Through' ports. We simultaneously measure on-chip, single-soliton conversion efficiencies of 45% and 25% for the two broadband comb outputs at the 'Drop' and 'Through' ports of a 48.9 GHz free-spectral range micro-ring resonator, obtaining a total conversion efficiency of 72%.
OUTPUT:
|
PubMed_Summ23067 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The association between Medicaid expansion and postoperative mortality after surgery for gynecologic cancer is unknown. Our objective was to compare 30- and 90-day postoperative mortality after gynecologic cancer surgery before and after 2014 in states that did and did not expand Medicaid.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Medicaid Expansion and Postoperative Mortality in Women with Gynecologic Cancer: A Difference-in-Difference Analysis."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The association between Medicaid expansion and postoperative mortality after surgery for gynecologic cancer is unknown. Our objective was to compare 30- and 90-day postoperative mortality after gynecologic cancer surgery before and after 2014 in states that did and did not expand Medicaid.
OUTPUT:
|
PubMed_Summ17643 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Nowadays, the role of two tightly interconnected systems, the inflammatory response system (IRS) and the compensatory immune response system (CIRS) in depression, is increasingly discussed. Various studies indicate pro-inflammatory activity in adolescent depression; however, there is an almost complete lack of findings about IRS and CIRS balance. Thus, we aimed to assess different IRS and CIRS indices, profiles, and IRS/CIRS ratios in drug-naïve MDD patients at adolescent age, with respect to sex.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Evaluation of Inflammatory Response System (IRS) and Compensatory Immune Response System (CIRS) in Adolescent Major Depression."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Nowadays, the role of two tightly interconnected systems, the inflammatory response system (IRS) and the compensatory immune response system (CIRS) in depression, is increasingly discussed. Various studies indicate pro-inflammatory activity in adolescent depression; however, there is an almost complete lack of findings about IRS and CIRS balance. Thus, we aimed to assess different IRS and CIRS indices, profiles, and IRS/CIRS ratios in drug-naïve MDD patients at adolescent age, with respect to sex.
OUTPUT:
|
PubMed_Summ8067 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The Forkhead-box (<i>FOX</i>) transcription factors, as one of the largest gene families in humans, play key roles in cancer. Although studies have suggested that several <i>FOX</i> transcription factors have a significant impact on cancer, the functions of most of the <i>FOX</i> genes in cancer remain elusive. In the study, the expression of 43 <i>FOX</i> genes in 63 kinds of cancer diseases (including many subtypes of same cancer) and in response to 60 chemical substances was obtained from the Gene Expression Atlas database of the European Bioinformatics Institute. Based on the high degree of overlap in <i>FOXO</i> family members differentially expressed in various cancers and their particular responses to chemotherapeutic drugs, our data disclosed the <i>FOX</i> genes that played an important role in the development and progression of cancer. More importantly, we predicted the role of one or several combinatorial <i>FOX</i> genes in the diagnosis and prognostic assessment of a specific cancer and evaluated the potential of a certain anticancer drug therapy for this type of cancer by integrating patterns of <i>FOX</i> genes expression with anticancer drugs sensitivity.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "An Integrated Study on the Differential Expression of the <i>FOX</i> Gene Family in Cancer and Their Response to Chemotherapy Drugs."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The Forkhead-box (<i>FOX</i>) transcription factors, as one of the largest gene families in humans, play key roles in cancer. Although studies have suggested that several <i>FOX</i> transcription factors have a significant impact on cancer, the functions of most of the <i>FOX</i> genes in cancer remain elusive. In the study, the expression of 43 <i>FOX</i> genes in 63 kinds of cancer diseases (including many subtypes of same cancer) and in response to 60 chemical substances was obtained from the Gene Expression Atlas database of the European Bioinformatics Institute. Based on the high degree of overlap in <i>FOXO</i> family members differentially expressed in various cancers and their particular responses to chemotherapeutic drugs, our data disclosed the <i>FOX</i> genes that played an important role in the development and progression of cancer. More importantly, we predicted the role of one or several combinatorial <i>FOX</i> genes in the diagnosis and prognostic assessment of a specific cancer and evaluated the potential of a certain anticancer drug therapy for this type of cancer by integrating patterns of <i>FOX</i> genes expression with anticancer drugs sensitivity.
OUTPUT:
|
PubMed_Summ11574 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: DDX3 is a DEAD-box RNA helicase with diverse biological functions through multicellular pathways. The objective of this study was to investigate the role of DDX3 in regulating melanogenesis by the exploring signaling pathways involved. Various concentrations of hydrogen peroxide were used to induce melanogenesis in SK-Mel-2 human melanoma cells. Melanin content assays, tyrosinase activity analysis, and Western blot analysis were performed to determine how DDX3 was involved in melanogenesis. Transient transfection was performed to overexpress or silence DDX3 genes. Immunoprecipitation was performed using an antityrosinase antibody. Based on the results of the cell viability test, melanin content, and activity of tyrosinase, a key melanogenesis enzyme, in SK-Mel-2 human melanoma cells, hydrogen peroxide at 0.1 mM was chosen to induce melanogenesis. Treatment with H\n OUTPUT:\n "
},
{
"from": "agent",
"value": "DDX3 Upregulates Hydrogen Peroxide-Induced Melanogenesis in Sk-Mel-2 Human Melanoma Cells."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: DDX3 is a DEAD-box RNA helicase with diverse biological functions through multicellular pathways. The objective of this study was to investigate the role of DDX3 in regulating melanogenesis by the exploring signaling pathways involved. Various concentrations of hydrogen peroxide were used to induce melanogenesis in SK-Mel-2 human melanoma cells. Melanin content assays, tyrosinase activity analysis, and Western blot analysis were performed to determine how DDX3 was involved in melanogenesis. Transient transfection was performed to overexpress or silence DDX3 genes. Immunoprecipitation was performed using an antityrosinase antibody. Based on the results of the cell viability test, melanin content, and activity of tyrosinase, a key melanogenesis enzyme, in SK-Mel-2 human melanoma cells, hydrogen peroxide at 0.1 mM was chosen to induce melanogenesis. Treatment with H
OUTPUT:
|
PubMed_Summ13381 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The waning vaccine immunity and emergence of new variants of SARS-CoV-2 led health authorities across the globe to administer booster doses (BDs) of the COVID-19 vaccine. Hence, the current study aimed to assess the COVID-19 vaccine booster hesitancy (VBH) amongst Pakistani healthcare professionals (HCPs).\n OUTPUT:\n "
},
{
"from": "agent",
"value": "COVID-19 Vaccine Booster Hesitancy (VBH) among Healthcare Professionals of Pakistan, a Nationwide Survey."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The waning vaccine immunity and emergence of new variants of SARS-CoV-2 led health authorities across the globe to administer booster doses (BDs) of the COVID-19 vaccine. Hence, the current study aimed to assess the COVID-19 vaccine booster hesitancy (VBH) amongst Pakistani healthcare professionals (HCPs).
OUTPUT:
|
PubMed_Summ22168 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Kappa-carrageenan (KC) esterification reaction with octenyl succinic anhydride was optimized using response surface methodology, leading to the production of a food-based emulsifier. Modified kappa-carrageenan (KC-OSA) with different degrees of substitution (DS) (0.023 and 0.045) was produced, and their functional and structural properties were investigated. The results from FTIR and \n OUTPUT:\n "
},
{
"from": "agent",
"value": "Preparation of octenyl succinylated kappa-carrageenan; reaction optimization, characterization, and application in low-fat vegan mayonnaise."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Kappa-carrageenan (KC) esterification reaction with octenyl succinic anhydride was optimized using response surface methodology, leading to the production of a food-based emulsifier. Modified kappa-carrageenan (KC-OSA) with different degrees of substitution (DS) (0.023 and 0.045) was produced, and their functional and structural properties were investigated. The results from FTIR and
OUTPUT:
|
PubMed_Summ16891 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Short instrumental streamflow records in the South and East Tibetan Plateau (SETP) limit understanding of the full range and long-term variability in streamflow, which could greatly impact freshwater resources for about one billion people downstream. Here we reconstruct eight centuries (1200-2012 C.E.) of annual streamflow from the Monsoon Asia Drought Atlas in five headwater regions across the SETP. We find two regional patterns, including northern (Yellow, Yangtze, and Lancang-Mekong) and southern (Nu-Salween and Yarlung Zangbo-Brahmaputra) SETP regions showing ten contrasting wet and dry periods, with a dividing line of regional moisture regimes at ~32°-33°N identified. We demonstrate strong temporal nonstationarity in streamflow variability, and reveal much greater high/low mean flow periods in terms of duration and magnitude: mostly pre-instrumental wetter conditions in the Yarlung Zangbo-Brahmaputra and drier conditions in other rivers. By contrast, the frequency of extreme flows during the instrumental periods for the Yangtze, Nu-Salween, and Yarlung Zangbo-Brahmaputra has increased by ~18% relative to the pre-instrumental periods.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Reconstructed eight-century streamflow in the Tibetan Plateau reveals contrasting regional variability and strong nonstationarity."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Short instrumental streamflow records in the South and East Tibetan Plateau (SETP) limit understanding of the full range and long-term variability in streamflow, which could greatly impact freshwater resources for about one billion people downstream. Here we reconstruct eight centuries (1200-2012 C.E.) of annual streamflow from the Monsoon Asia Drought Atlas in five headwater regions across the SETP. We find two regional patterns, including northern (Yellow, Yangtze, and Lancang-Mekong) and southern (Nu-Salween and Yarlung Zangbo-Brahmaputra) SETP regions showing ten contrasting wet and dry periods, with a dividing line of regional moisture regimes at ~32°-33°N identified. We demonstrate strong temporal nonstationarity in streamflow variability, and reveal much greater high/low mean flow periods in terms of duration and magnitude: mostly pre-instrumental wetter conditions in the Yarlung Zangbo-Brahmaputra and drier conditions in other rivers. By contrast, the frequency of extreme flows during the instrumental periods for the Yangtze, Nu-Salween, and Yarlung Zangbo-Brahmaputra has increased by ~18% relative to the pre-instrumental periods.
OUTPUT:
|
PubMed_Summ19339 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Medical marijuana (MMJ) was legalized in November 2016 with the passing of Amendment 2 in the state of Florida. Since the legalization, many studies have been conducted to understand the direct effect medical marijuana has on specific medical conditions. Unlike most allopathic drugs, medical marijuana does not target single ailments or specific conditions and does not follow precise recommending guidelines. There is scarce knowledge on how patient characteristics, including medical conditions, affect a physician's direct recommendations and registry limits. To obtain insight on the effect patient characteristics have on the clinical decision-making process, we conducted ten qualitative interviews of medical marijuana physicians who are certified to order medical marijuana for patients in Florida. Interview topics ranged from typical daily practice to specific recommendations for patient histories. Each interview was transcribed and thematically analyzed. Five major patient characteristics that influence a physician's recommendation emerged from the interviews: patient medical history, co-medications, lifestyle, marijuana experience level and counter-indications. Each category was analyzed further to understand how the characteristics influenced the practice of recommending and ordering product. Physicians emphasized the equivalent importance of reviewing a patient's medical history, lifestyle, and past marijuana experiences while also expressing the need to look holistically at the individual patient. Instead of the characteristics determining what the physician recommends for the patient and orders through the registry, the characteristics dictate the education given to the patient so that the patient may lead and determine their own individual care.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Clinical Decision Making by Medical Marijuana Physicians in Florida: A Qualitative Assessment."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Medical marijuana (MMJ) was legalized in November 2016 with the passing of Amendment 2 in the state of Florida. Since the legalization, many studies have been conducted to understand the direct effect medical marijuana has on specific medical conditions. Unlike most allopathic drugs, medical marijuana does not target single ailments or specific conditions and does not follow precise recommending guidelines. There is scarce knowledge on how patient characteristics, including medical conditions, affect a physician's direct recommendations and registry limits. To obtain insight on the effect patient characteristics have on the clinical decision-making process, we conducted ten qualitative interviews of medical marijuana physicians who are certified to order medical marijuana for patients in Florida. Interview topics ranged from typical daily practice to specific recommendations for patient histories. Each interview was transcribed and thematically analyzed. Five major patient characteristics that influence a physician's recommendation emerged from the interviews: patient medical history, co-medications, lifestyle, marijuana experience level and counter-indications. Each category was analyzed further to understand how the characteristics influenced the practice of recommending and ordering product. Physicians emphasized the equivalent importance of reviewing a patient's medical history, lifestyle, and past marijuana experiences while also expressing the need to look holistically at the individual patient. Instead of the characteristics determining what the physician recommends for the patient and orders through the registry, the characteristics dictate the education given to the patient so that the patient may lead and determine their own individual care.
OUTPUT:
|
PubMed_Summ19976 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Lymphoma is a type of lymphatic tissue originated cancer. Automatic and accurate lymphoma segmentation is critical for its diagnosis and prognosis yet challenging due to the severely class-imbalanced problem. Generally, deep neural networks trained with class-observation-frequency based re-weighting loss functions are used to address this problem. However, the majority class can be under-weighted by them, due to the existence of data overlap. Besides, they are more mis-calibrated. To resolve these, we propose a neural network with prior-shift regularization (PSR-Net), which comprises a UNet-like backbone with re-weighting loss functions, and a prior-shift regularization (PSR) module including a prior-shift layer (PSL), a regularizer generation layer (RGL), and an expected prediction confidence updating layer (EPCUL). We first propose a trainable expected prediction confidence (EPC) for each class. Periodically, PSL shifts a prior training dataset to a more informative dataset based on EPCs; RGL presents a generalized informative-voxel-aware (GIVA) loss with EPCs and calculates it on the informative dataset for model finetuning in back-propagation; and EPCUL updates EPCs to refresh PSL and RRL in next forward-propagation. PSR-Net is trained in a two- stage manner. The backbone is first trained with re-weighting loss functions, then we reload the best saved model for the backbone and continue to train it with the weighted sum of the re-weighting loss functions, the GIVA regularizer and the L2 loss function of EPCs for regularization fine-tuning. Extensive experiments are performed based on PET/CT volumes with advanced stage lymphomas. Our PSR-Net achieves 95.12% sensitivity and 87.18% Dice coefficient, demonstrating the effectiveness of PSR-Net, when compared to the baselines and the state-of-the-arts.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "PSR-Nets: Deep neural networks with prior shift regularization for PET/CT based automatic, accurate, and calibrated whole-body lymphoma segmentation."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Lymphoma is a type of lymphatic tissue originated cancer. Automatic and accurate lymphoma segmentation is critical for its diagnosis and prognosis yet challenging due to the severely class-imbalanced problem. Generally, deep neural networks trained with class-observation-frequency based re-weighting loss functions are used to address this problem. However, the majority class can be under-weighted by them, due to the existence of data overlap. Besides, they are more mis-calibrated. To resolve these, we propose a neural network with prior-shift regularization (PSR-Net), which comprises a UNet-like backbone with re-weighting loss functions, and a prior-shift regularization (PSR) module including a prior-shift layer (PSL), a regularizer generation layer (RGL), and an expected prediction confidence updating layer (EPCUL). We first propose a trainable expected prediction confidence (EPC) for each class. Periodically, PSL shifts a prior training dataset to a more informative dataset based on EPCs; RGL presents a generalized informative-voxel-aware (GIVA) loss with EPCs and calculates it on the informative dataset for model finetuning in back-propagation; and EPCUL updates EPCs to refresh PSL and RRL in next forward-propagation. PSR-Net is trained in a two- stage manner. The backbone is first trained with re-weighting loss functions, then we reload the best saved model for the backbone and continue to train it with the weighted sum of the re-weighting loss functions, the GIVA regularizer and the L2 loss function of EPCs for regularization fine-tuning. Extensive experiments are performed based on PET/CT volumes with advanced stage lymphomas. Our PSR-Net achieves 95.12% sensitivity and 87.18% Dice coefficient, demonstrating the effectiveness of PSR-Net, when compared to the baselines and the state-of-the-arts.
OUTPUT:
|
PubMed_Summ25244 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Abnormal oncogenic signatures provide important clues regarding cancer prognosis and treatment. We analysed the variations in 189 oncogenic signature gene sets between normal and tumourous tissues from The Cancer Genome Atlas (TCGA) and found that the \"CSR_LATE_UP\" signature was the most upregulated oncogenic signature gene set in bladder cancer. Next, we developed a common serum response (CSR) risk score (CRS) model based on fibroblast CSR genes and systematically analysed the correlations of these genes or the CRSs with survival, previously reported molecular subtypes, clinicopathological features, cancer signalling pathways, chemotherapeutic responses, and the tumour microenvironment using TCGA and validation cohorts. The CRS could predict the malignant phenotype, chemotherapeutic efficacy, immune invasion, and disease prognosis. Inflammatory signalling pathways (e.g., inflammatory response, TNFA signalling via NFƘB, IFN\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Fibroblast Common Serum Response Signature-Related Classification Affects the Tumour Microenvironment and Predicts Prognosis in Bladder Cancer."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Abnormal oncogenic signatures provide important clues regarding cancer prognosis and treatment. We analysed the variations in 189 oncogenic signature gene sets between normal and tumourous tissues from The Cancer Genome Atlas (TCGA) and found that the "CSR_LATE_UP" signature was the most upregulated oncogenic signature gene set in bladder cancer. Next, we developed a common serum response (CSR) risk score (CRS) model based on fibroblast CSR genes and systematically analysed the correlations of these genes or the CRSs with survival, previously reported molecular subtypes, clinicopathological features, cancer signalling pathways, chemotherapeutic responses, and the tumour microenvironment using TCGA and validation cohorts. The CRS could predict the malignant phenotype, chemotherapeutic efficacy, immune invasion, and disease prognosis. Inflammatory signalling pathways (e.g., inflammatory response, TNFA signalling via NFƘB, IFN
OUTPUT:
|
PubMed_Summ9940 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This paper focuses on a novel application of personalized medicine: the ways one thinks about health (i.e., appraisal processes) as relevant predictors of spine-surgery response. This prospective longitudinal cohort study (n = 235) investigated how appraisal processes relate to outcomes of spinal decompression and/or fusion surgery, from pre-surgery through one-year post-surgery. Patient-reported outcomes assessed spine-specific disability (Oswestry Disability Index (ODI)), mental health functioning (Rand-36 Mental Component Score (MCS)), and cognitive appraisal processes (how people recall past experiences and to whom they compare themselves). Analysis of Variance examined the appraisal-outcomes association in separate models at pre-surgery, 3 months, and 12 months. We found that appraisal processes explained less variance at pre-surgery than later and were differentially relevant to health outcomes at different times in the spine-surgery recovery trajectory. For the ODI, recall of the seriousness of their condition was most prominent early in recovery, and comparing themselves to positive standards was most prominent later. For the MCS, not focusing on the negative aspects of their condition and/or on how others see them was associated with steady improvement and higher scores at 12 months. Appraisal processes are relevant to both spine-specific disability and mental-health functioning. Such processes are modifiable objects of attention for personalizing spine-surgery outcomes.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Cognitive Processes during Recovery: Moving toward Personalized Spine Surgery Outcomes."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: This paper focuses on a novel application of personalized medicine: the ways one thinks about health (i.e., appraisal processes) as relevant predictors of spine-surgery response. This prospective longitudinal cohort study (n = 235) investigated how appraisal processes relate to outcomes of spinal decompression and/or fusion surgery, from pre-surgery through one-year post-surgery. Patient-reported outcomes assessed spine-specific disability (Oswestry Disability Index (ODI)), mental health functioning (Rand-36 Mental Component Score (MCS)), and cognitive appraisal processes (how people recall past experiences and to whom they compare themselves). Analysis of Variance examined the appraisal-outcomes association in separate models at pre-surgery, 3 months, and 12 months. We found that appraisal processes explained less variance at pre-surgery than later and were differentially relevant to health outcomes at different times in the spine-surgery recovery trajectory. For the ODI, recall of the seriousness of their condition was most prominent early in recovery, and comparing themselves to positive standards was most prominent later. For the MCS, not focusing on the negative aspects of their condition and/or on how others see them was associated with steady improvement and higher scores at 12 months. Appraisal processes are relevant to both spine-specific disability and mental-health functioning. Such processes are modifiable objects of attention for personalizing spine-surgery outcomes.
OUTPUT:
|
PubMed_Summ19506 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Sensory processing abilities are highly variable within and across people diagnosed with autism and attention-deficit/hyperactivity disorder (ADHD). This study examined the transdiagnostic nature of sensory processing abilities, and their association with features of autism and ADHD, in a large sample of autistic people (n = 495) and people with ADHD (n = 461). Five similar data-driven sensory phenotypes characterized sensory processing abilities, and showed similar patterns of association with features of autism and ADHD, across both diagnostic groups. These results demonstrate the transdiagnostic nature of sensory processing abilities, while contributing to a growing body of literature that suggests the autism and ADHD diagnostic labels have poor explanatory power.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Transdiagnostic Patterns of Sensory Processing in Autism and ADHD."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Sensory processing abilities are highly variable within and across people diagnosed with autism and attention-deficit/hyperactivity disorder (ADHD). This study examined the transdiagnostic nature of sensory processing abilities, and their association with features of autism and ADHD, in a large sample of autistic people (n = 495) and people with ADHD (n = 461). Five similar data-driven sensory phenotypes characterized sensory processing abilities, and showed similar patterns of association with features of autism and ADHD, across both diagnostic groups. These results demonstrate the transdiagnostic nature of sensory processing abilities, while contributing to a growing body of literature that suggests the autism and ADHD diagnostic labels have poor explanatory power.
OUTPUT:
|
PubMed_Summ10360 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To achieve good long-term temperature stability in devices used in energy-conversion applications, this study is aimed at developing combined ceramics, referred to as PZN-PMN-PZT, comprising Pb(Zn\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Development of PZN-PMN-PZT Piezoelectric Ceramics with High d"
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: To achieve good long-term temperature stability in devices used in energy-conversion applications, this study is aimed at developing combined ceramics, referred to as PZN-PMN-PZT, comprising Pb(Zn
OUTPUT:
|
PubMed_Summ11753 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The layered Ni-rich NiCoMn (NCM)-based cathode active material Li[Ni\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Electrochemical Performance of Layer-Structured Ni"
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The layered Ni-rich NiCoMn (NCM)-based cathode active material Li[Ni
OUTPUT:
|
PubMed_Summ4917 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The involvement of the immune system in pregnancy is a controversial subject. The functions of T helper (Th) 1 and Th2 cells have been proposed, that Th1 cytokines promoting allograft rejection may impair pregnancy, whereas Th2-type cytokines suppressing Th1 responses improve allograft tolerance and hence embryonic survival. Maternal-fetal tolerance begins in the uterus; therefore, optimal adaptation to the fetus is the result of a complex interference. The invasion of extravillous trophoblast cells (EVTs) into the decidua and the inner third of the myometrium is essential for a healthy pregnancy. The mechanisms that influence trophoblast invasion are unknown; however, cytokines from uterine natural killer (uNK) cells, NKT cells, macrophages, and T cells appear to be involved. All these cells are major sources of interferon gamma (IFN-γ). Recent studies have shown that IFN-γ can inhibit EVT invasion via a mechanism dependent on an increase in EVT apoptosis and a decrease in matrix metalloproteinases (MMPs). Regarding controversies in this context, this study aimed to comprehensively review the role of IFN-γ and IFN-γ-producing cells in EVT invasion, successful pregnancy, and preeclampsia.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "The Role of Interferon (IFN)-γ in Extravillous Trophoblast Cell (EVT) Invasion and Preeclampsia Progression."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The involvement of the immune system in pregnancy is a controversial subject. The functions of T helper (Th) 1 and Th2 cells have been proposed, that Th1 cytokines promoting allograft rejection may impair pregnancy, whereas Th2-type cytokines suppressing Th1 responses improve allograft tolerance and hence embryonic survival. Maternal-fetal tolerance begins in the uterus; therefore, optimal adaptation to the fetus is the result of a complex interference. The invasion of extravillous trophoblast cells (EVTs) into the decidua and the inner third of the myometrium is essential for a healthy pregnancy. The mechanisms that influence trophoblast invasion are unknown; however, cytokines from uterine natural killer (uNK) cells, NKT cells, macrophages, and T cells appear to be involved. All these cells are major sources of interferon gamma (IFN-γ). Recent studies have shown that IFN-γ can inhibit EVT invasion via a mechanism dependent on an increase in EVT apoptosis and a decrease in matrix metalloproteinases (MMPs). Regarding controversies in this context, this study aimed to comprehensively review the role of IFN-γ and IFN-γ-producing cells in EVT invasion, successful pregnancy, and preeclampsia.
OUTPUT:
|
PubMed_Summ10064 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Regarding COVID-19 infection, Bulgaria has one of the lowest rates of vaccination in Europe, and its COVID-19-related mortality rate has been one of the highest in the European Union. Chronic kidney disease (CKD)-COVID-19 patients are at higher risk of developing acute kidney injury (AKI) and death after hospital admission. This single-center prospective cohort study from Bulgaria included 120 in-patient COVID-19 subjects of whom 70 had CKD and 50 normal renal function. Diabetes mellitus, hypertension, obesity, and cardiovascular disease were statistically more prevalent in the CKD group as compared to the non-CKD group. At admission, D-dimer, creatinine, and urea levels were significantly higher in the CKD group, whereas estimated glomerular-filtration rate was significantly lower as compared to the non-CKD patients. During hospitalization, 23 patients (19.1%) died, of which 19 were in the CKD group (\n OUTPUT:\n "
},
{
"from": "agent",
"value": "COVID-19 Infection in Chronic Kidney Disease Patients in Bulgaria: Risk Factors for Death and Acute Kidney Injury."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Regarding COVID-19 infection, Bulgaria has one of the lowest rates of vaccination in Europe, and its COVID-19-related mortality rate has been one of the highest in the European Union. Chronic kidney disease (CKD)-COVID-19 patients are at higher risk of developing acute kidney injury (AKI) and death after hospital admission. This single-center prospective cohort study from Bulgaria included 120 in-patient COVID-19 subjects of whom 70 had CKD and 50 normal renal function. Diabetes mellitus, hypertension, obesity, and cardiovascular disease were statistically more prevalent in the CKD group as compared to the non-CKD group. At admission, D-dimer, creatinine, and urea levels were significantly higher in the CKD group, whereas estimated glomerular-filtration rate was significantly lower as compared to the non-CKD patients. During hospitalization, 23 patients (19.1%) died, of which 19 were in the CKD group (
OUTPUT:
|
PubMed_Summ15269 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The aim of this study was to investigate the effect of a high-fat meal on the single-dose pharmacokinetics (PK) and tolerability of HMPL-689 in Chinese healthy volunteers. In this study, 34 eligible male volunteers received a single 30-mg dose of HMPL-689 capsules following an overnight fast or a high-fat breakfast prior to dosing. Blood samples were collected at the designated time points for pharmacokinetic analysis. Safety and tolerability were assessed throughout the study. Total 32 healthy male volunteers were completed in the study. The GMRs of AUC\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Effect of a high-fat meal on the relative bioavailability of HMPL-689 in Chinese healthy volunteers."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The aim of this study was to investigate the effect of a high-fat meal on the single-dose pharmacokinetics (PK) and tolerability of HMPL-689 in Chinese healthy volunteers. In this study, 34 eligible male volunteers received a single 30-mg dose of HMPL-689 capsules following an overnight fast or a high-fat breakfast prior to dosing. Blood samples were collected at the designated time points for pharmacokinetic analysis. Safety and tolerability were assessed throughout the study. Total 32 healthy male volunteers were completed in the study. The GMRs of AUC
OUTPUT:
|
PubMed_Summ5669 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study aimed to examine the effect of taurolidine irrigation on preventing surgical site infection by comparing the spinal infection rate after spinal fusion surgery using vancomycin powder application and taurolidine irrigation. Of 1081 participants, 369 underwent taurolidine irrigation, 221 underwent vancomycin powder application, and 491 were controls. Of the 20 surgical site infections (1.85%), 14 occurred in the control group (2.85%), 5 in the vancomycin group (2.26%), and 1 (0.27%) in the taurolidine group. Among the various variables, age at the time of surgery, smoking, surgical site, and hemovac removal time were significant in the univariate logistic regression. The final result was derived after variable selection using the stepwise method. In the univariate model, the odds ratios were 0.09 and 0.79 in each of the vancomycin and taurolidine groups compared to that of the control group. In the multivariate model, the odds ratios were 0.09 and 0.83 in each of the vancomycin and taurolidine groups compared to that of the control group. The preventive effect of vancomycin powder application was not statistically significant. However, the vancomycin group showed a less effective tendency than the taurolidine group. Taurolidine irrigation may be a good substitute for the vancomycin powder application.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Is Vancomycin More Effective than Taurolidine? Comparative Analysis of Their Preventive Effect against Spinal Infection in 1000 Patients with Spinal Fusion."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: This study aimed to examine the effect of taurolidine irrigation on preventing surgical site infection by comparing the spinal infection rate after spinal fusion surgery using vancomycin powder application and taurolidine irrigation. Of 1081 participants, 369 underwent taurolidine irrigation, 221 underwent vancomycin powder application, and 491 were controls. Of the 20 surgical site infections (1.85%), 14 occurred in the control group (2.85%), 5 in the vancomycin group (2.26%), and 1 (0.27%) in the taurolidine group. Among the various variables, age at the time of surgery, smoking, surgical site, and hemovac removal time were significant in the univariate logistic regression. The final result was derived after variable selection using the stepwise method. In the univariate model, the odds ratios were 0.09 and 0.79 in each of the vancomycin and taurolidine groups compared to that of the control group. In the multivariate model, the odds ratios were 0.09 and 0.83 in each of the vancomycin and taurolidine groups compared to that of the control group. The preventive effect of vancomycin powder application was not statistically significant. However, the vancomycin group showed a less effective tendency than the taurolidine group. Taurolidine irrigation may be a good substitute for the vancomycin powder application.
OUTPUT:
|
PubMed_Summ2388 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Articular cartilage (AC) degradation is a recurrent pathology that affects millions of people worldwide. Polyvinyl alcohol (PVA) hydrogels have been widely explored for AC replacement. However, their mechanical performance is generally inadequate, and these materials need to be reinforced. Moreover, to be used in a clinical setting, such materials must undergo effective sterilisation. In this work, a PVA hydrogel reinforced with poly(p-phenylene-2,6-benzobisoxazole) (PBO) nanofibres was submitted to three non-conventional sterilisation methods: microwave (MW), high hydrostatic pressure (HHP), and plasma (PM), in order to evaluate their impact on the properties of the material. Sterilisation was achieved in all cases. Properties such as water content and hydrophilicity were not affected. FTIR analysis indicated some changes in crystallinity and/or crosslinking in all cases. MW was revealed to be the most suitable method, since, unlike to PM and HHP, it led to a general improvement of the materials' properties: increasing the hardness, stiffness (both in tensile and compression), and shear modulus, and also leading to a decrease in the coefficient of friction against porcine cartilage. Furthermore, the samples remained non-irritant and non-cytotoxic. Moreover, this method allows terminal sterilisation in a short time (3 min) and using accessible equipment.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Effects of Non-Conventional Sterilisation Methods on PBO-Reinforced PVA Hydrogels for Cartilage Replacement."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Articular cartilage (AC) degradation is a recurrent pathology that affects millions of people worldwide. Polyvinyl alcohol (PVA) hydrogels have been widely explored for AC replacement. However, their mechanical performance is generally inadequate, and these materials need to be reinforced. Moreover, to be used in a clinical setting, such materials must undergo effective sterilisation. In this work, a PVA hydrogel reinforced with poly(p-phenylene-2,6-benzobisoxazole) (PBO) nanofibres was submitted to three non-conventional sterilisation methods: microwave (MW), high hydrostatic pressure (HHP), and plasma (PM), in order to evaluate their impact on the properties of the material. Sterilisation was achieved in all cases. Properties such as water content and hydrophilicity were not affected. FTIR analysis indicated some changes in crystallinity and/or crosslinking in all cases. MW was revealed to be the most suitable method, since, unlike to PM and HHP, it led to a general improvement of the materials' properties: increasing the hardness, stiffness (both in tensile and compression), and shear modulus, and also leading to a decrease in the coefficient of friction against porcine cartilage. Furthermore, the samples remained non-irritant and non-cytotoxic. Moreover, this method allows terminal sterilisation in a short time (3 min) and using accessible equipment.
OUTPUT:
|
PubMed_Summ18502 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Case report of a patient with no significant past medical history who presented with reports of dizziness, dyspnea on exertion, and palpitations that had been ongoing for at least 5 years. It demonstrates the importance of considering the presence of an inter-atrial shunt when evaluating a patient with an unexplained dilated right atrium and right ventricle.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "A Patient with Dyspnea and an Enlarged Right Ventricle."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Case report of a patient with no significant past medical history who presented with reports of dizziness, dyspnea on exertion, and palpitations that had been ongoing for at least 5 years. It demonstrates the importance of considering the presence of an inter-atrial shunt when evaluating a patient with an unexplained dilated right atrium and right ventricle.
OUTPUT:
|
PubMed_Summ819 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: CRISPR tools can generate knockout and knock-in animal models easily, but the models can contain off-target genomic lesions or random insertions of donor DNAs. Simpler methods to identify off-target lesions and random insertions, using tail or earpiece DNA, are unavailable. We develop CRISPR-KRISPR (CRISPR-Knock-ins and Random Inserts Searching PRotocol), a method to identify both off-target lesions and random insertions. CRISPR-KRISPR uses as little as 3.4 μg of genomic DNA; thus, it can be easily incorporated as an additional step to genotype founder animals for further breeding.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "CRISPR-KRISPR: a method to identify on-target and random insertion of donor DNAs and their characterization in knock-in mice."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: CRISPR tools can generate knockout and knock-in animal models easily, but the models can contain off-target genomic lesions or random insertions of donor DNAs. Simpler methods to identify off-target lesions and random insertions, using tail or earpiece DNA, are unavailable. We develop CRISPR-KRISPR (CRISPR-Knock-ins and Random Inserts Searching PRotocol), a method to identify both off-target lesions and random insertions. CRISPR-KRISPR uses as little as 3.4 μg of genomic DNA; thus, it can be easily incorporated as an additional step to genotype founder animals for further breeding.
OUTPUT:
|
PubMed_Summ24168 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: As a systemic skeletal dysfunction, osteoporosis (OP) is characterized by low bone mass and bone microarchitectural damage. The global incidences of OP are high.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Prognostic analysis and validation of diagnostic marker genes in patients with osteoporosis."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: As a systemic skeletal dysfunction, osteoporosis (OP) is characterized by low bone mass and bone microarchitectural damage. The global incidences of OP are high.
OUTPUT:
|
PubMed_Summ2489 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Haloperidol is frequently used to treat delirium in patients in the intensive care unit (ICU), but evidence of its effect is limited.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Haloperidol for the Treatment of Delirium in ICU Patients."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Haloperidol is frequently used to treat delirium in patients in the intensive care unit (ICU), but evidence of its effect is limited.
OUTPUT:
|
PubMed_Summ678 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The structure of natural scenes is signaled by many visual cues. Principal amongst them are the binocular disparities created by the laterally separated viewpoints of the two eyes. Disparity cues are believed to be processed hierarchically, first in terms of local measurements of absolute disparity and second in terms of more global measurements of relative disparity that allow extraction of the depth structure of a scene. Psychophysical and oculomotor studies have suggested that relative disparities are particularly relevant to perception, whilst absolute disparities are not. Here, we compare neural responses to stimuli that isolate the absolute disparity cue with stimuli that contain additional relative disparity cues, using the high temporal resolution of EEG to determine the temporal order of absolute and relative disparity processing. By varying the observers' task, we assess the extent to which each cue is cognitively penetrable. We find that absolute disparity is extracted before relative disparity, and that task effects arise only at or after the extraction of relative disparity. Our results indicate a hierarchy of disparity processing stages leading to the formation of a proto-object representation upon which higher cognitive processes can act.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Cognitive penetrability of scene representations based on horizontal image disparities."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The structure of natural scenes is signaled by many visual cues. Principal amongst them are the binocular disparities created by the laterally separated viewpoints of the two eyes. Disparity cues are believed to be processed hierarchically, first in terms of local measurements of absolute disparity and second in terms of more global measurements of relative disparity that allow extraction of the depth structure of a scene. Psychophysical and oculomotor studies have suggested that relative disparities are particularly relevant to perception, whilst absolute disparities are not. Here, we compare neural responses to stimuli that isolate the absolute disparity cue with stimuli that contain additional relative disparity cues, using the high temporal resolution of EEG to determine the temporal order of absolute and relative disparity processing. By varying the observers' task, we assess the extent to which each cue is cognitively penetrable. We find that absolute disparity is extracted before relative disparity, and that task effects arise only at or after the extraction of relative disparity. Our results indicate a hierarchy of disparity processing stages leading to the formation of a proto-object representation upon which higher cognitive processes can act.
OUTPUT:
|
PubMed_Summ16559 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Upstream anthropogenic land cover can degrade source drinking water quality and thereby inhibit the ability of a community water system to provide safe drinking water. This study aimed to predict differences in Safe Drinking Water Act (SDWA) compliance between water systems based on upstream land cover in Central Appalachia and to examine whether national trends correlating violations with system size and source type were relevant for this region. Multiple generalized linear mixed models assessed relationships between SDWA violations and the distance weighted land cover proportions associated with the water system's contributing source watershed, as well as county economic status, system size, and water source. Results indicate that rates of monitoring and reporting violations were significantly higher for smaller water systems in more economically distressed counties. Interestingly, increases in surface mining landuse and high density development decreased monitoring and reporting violations, which may reflect impacts of associated economic development. Increases in low intensity development increased the likelihood of health-based violations. To protect public health, community managers should consider source water protection and/or upgrading drinking water system treatment capacity prior to developing previously undeveloped areas and further motivate compliance with monitoring and reporting requirements.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Land cover and community water system characteristics as predictors of Safe Drinking Water Act violations in Central Appalachia, USA."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Upstream anthropogenic land cover can degrade source drinking water quality and thereby inhibit the ability of a community water system to provide safe drinking water. This study aimed to predict differences in Safe Drinking Water Act (SDWA) compliance between water systems based on upstream land cover in Central Appalachia and to examine whether national trends correlating violations with system size and source type were relevant for this region. Multiple generalized linear mixed models assessed relationships between SDWA violations and the distance weighted land cover proportions associated with the water system's contributing source watershed, as well as county economic status, system size, and water source. Results indicate that rates of monitoring and reporting violations were significantly higher for smaller water systems in more economically distressed counties. Interestingly, increases in surface mining landuse and high density development decreased monitoring and reporting violations, which may reflect impacts of associated economic development. Increases in low intensity development increased the likelihood of health-based violations. To protect public health, community managers should consider source water protection and/or upgrading drinking water system treatment capacity prior to developing previously undeveloped areas and further motivate compliance with monitoring and reporting requirements.
OUTPUT:
|
PubMed_Summ14773 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Adults with β- thalassemia major (β-TM) develop low BMD and fragility fractures at a higher incidence and at a younger age compared to the general population. The disease itself, including direct effects of anemia and iron overload toxicity on bone turnover, genetic susceptibility, thalassemia-related endocrinopathies and acquittance of suboptimal peak bone mass contribute to low bone mass and increased bone fragility frequently encountered among these patients. Current management of osteoporosis requires long-term treatment that can be provided by agents that reduce the risk of all osteoporotic fractures by modulating bone metabolism with different mechanisms of action. These include inhibitors of bone remodeling (e.g., bisphosphonates, denosumab) and stimulators of bone formation (e.g., PTHR1 agonists and sclerostin antibodies). Considering the unique characteristics of osteoporosis associated with β-TM and the clinical importance of balancing the risk/benefit of treatment in the long-term, appropriate use of these therapeutic approaches is essential for patient care. In this review we outline current literature on the use of anti-osteoporotic drugs in β-TM patients with osteoporosis focusing on data on the efficacy, safety, and duration of treatment. In addition, we propose a long-term management plan for β-TM -associated osteoporosis aiming at the optimal patient care for this special population.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Approach to the management of β thalassemia major associated osteoporosis - A long-standing relationship revisited."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Adults with β- thalassemia major (β-TM) develop low BMD and fragility fractures at a higher incidence and at a younger age compared to the general population. The disease itself, including direct effects of anemia and iron overload toxicity on bone turnover, genetic susceptibility, thalassemia-related endocrinopathies and acquittance of suboptimal peak bone mass contribute to low bone mass and increased bone fragility frequently encountered among these patients. Current management of osteoporosis requires long-term treatment that can be provided by agents that reduce the risk of all osteoporotic fractures by modulating bone metabolism with different mechanisms of action. These include inhibitors of bone remodeling (e.g., bisphosphonates, denosumab) and stimulators of bone formation (e.g., PTHR1 agonists and sclerostin antibodies). Considering the unique characteristics of osteoporosis associated with β-TM and the clinical importance of balancing the risk/benefit of treatment in the long-term, appropriate use of these therapeutic approaches is essential for patient care. In this review we outline current literature on the use of anti-osteoporotic drugs in β-TM patients with osteoporosis focusing on data on the efficacy, safety, and duration of treatment. In addition, we propose a long-term management plan for β-TM -associated osteoporosis aiming at the optimal patient care for this special population.
OUTPUT:
|
PubMed_Summ18330 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cardiovascular risk due to obesity can be improved greatly by bariatric surgery. However, there is no research involving appropriate model for evaluating cardiovascular disease risk reduction in bariatric surgery for obesity in China. We selected the ischemic cardiovascular disease (ICVD) risk score that accurately predict cardiovascular risk in Chinese adults to evaluate the 10-year risk of ICVD and estimated early cardiovascular benefits of bariatric surgery in obese Chinese patients through its reduction.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Reducing the 10-year risk of ischemic cardiovascular disease to receive early cardiovascular benefits from bariatric surgery for obesity in China."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Cardiovascular risk due to obesity can be improved greatly by bariatric surgery. However, there is no research involving appropriate model for evaluating cardiovascular disease risk reduction in bariatric surgery for obesity in China. We selected the ischemic cardiovascular disease (ICVD) risk score that accurately predict cardiovascular risk in Chinese adults to evaluate the 10-year risk of ICVD and estimated early cardiovascular benefits of bariatric surgery in obese Chinese patients through its reduction.
OUTPUT:
|
PubMed_Summ23123 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes. Moreover, rats fed an obesogenic diet during lactation have higher miR-222 content in breast milk and the offspring display greater body fat mass and impaired insulin sensitivity in adulthood. In order to investigate the molecular mechanisms involved and to dissect the specific effects of miR-222 on adipocytes, transfection with a mimic or an inhibitor of miR-222 has been conducted on 3T3-L1 preadipocytes. 3T3-L1 cells were transfected with either a mimic or an inhibitor of miR-222 and collected after 2 days (preadipocytes) or 8 days (mature adipocytes) for transcriptomic analysis. Results showed a relevant impact on pathways associated with insulin signaling, lipid metabolism and adipogenesis. Outcomes in key genes and proteins were further analyzed with quantitative reverse transcription polymerase chain reaction and Western Blotting, respectively, which displayed a general inhibition in important effectors of the identified routes under miR-222 mimic treatment in preadipocytes. Although to a lesser extent, this overall signature was maintained in differentiated adipocytes. Altogether, miR-222 exerts a direct effect in metabolic pathways of 3T3-L1 adipocytes that are relevant to adipocyte function, limiting adipogenesis and insulin signaling pathways, offering a mechanistic explanation for its reported association with metabolic diseases.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "miR-222 exerts negative regulation on insulin signaling pathway in 3T3-L1 adipocytes."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Increased miR-222 levels are associated with metabolic syndrome, insulin resistance, and diabetes. Moreover, rats fed an obesogenic diet during lactation have higher miR-222 content in breast milk and the offspring display greater body fat mass and impaired insulin sensitivity in adulthood. In order to investigate the molecular mechanisms involved and to dissect the specific effects of miR-222 on adipocytes, transfection with a mimic or an inhibitor of miR-222 has been conducted on 3T3-L1 preadipocytes. 3T3-L1 cells were transfected with either a mimic or an inhibitor of miR-222 and collected after 2 days (preadipocytes) or 8 days (mature adipocytes) for transcriptomic analysis. Results showed a relevant impact on pathways associated with insulin signaling, lipid metabolism and adipogenesis. Outcomes in key genes and proteins were further analyzed with quantitative reverse transcription polymerase chain reaction and Western Blotting, respectively, which displayed a general inhibition in important effectors of the identified routes under miR-222 mimic treatment in preadipocytes. Although to a lesser extent, this overall signature was maintained in differentiated adipocytes. Altogether, miR-222 exerts a direct effect in metabolic pathways of 3T3-L1 adipocytes that are relevant to adipocyte function, limiting adipogenesis and insulin signaling pathways, offering a mechanistic explanation for its reported association with metabolic diseases.
OUTPUT:
|
PubMed_Summ22067 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Radix Glycyrrhizae (GL), a herbal medicine that is widely available, has shown advantages for a variety of inflammatory diseases. Toll like receptor 4 (TLR4) pathway has been shown to play a key role in the progression of inflammation.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Radix Glycyrrhizae extract and licochalcone a exert an anti-inflammatory action by direct suppression of toll like receptor 4."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Radix Glycyrrhizae (GL), a herbal medicine that is widely available, has shown advantages for a variety of inflammatory diseases. Toll like receptor 4 (TLR4) pathway has been shown to play a key role in the progression of inflammation.
OUTPUT:
|
PubMed_Summ6105 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: As a pleiotropic regulator, Antibiotic resistant protein B (AbrB) was reported to play important roles in various cellular processes in \n OUTPUT:\n "
},
{
"from": "agent",
"value": "The Physiological Functions of AbrB on Sporulation, Biofilm Formation and Carbon Source Utilization in "
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: As a pleiotropic regulator, Antibiotic resistant protein B (AbrB) was reported to play important roles in various cellular processes in
OUTPUT:
|
PubMed_Summ4424 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Various minimally invasive procedures for treating discogenic pain have been reported in recent years. A Disc-FX® system can be used to perform nucleus pulposus (NP) removal, radiofrequency ablation, and annuloplasty under the guidance of x-ray fluoroscopy. However, when a probe tip with focused heat is placed on the intradiscal/subannular area to perform nucleo-annuloplasty using radiofrequency lesioning, thermal injury to the spinal cord or spinal nerves is a concern.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Changes in Temperature Following Radiofrequency Thermal Ablation of the Nucleus Pulposus and Annulus Fibrosus: A Cadaveric Study."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Various minimally invasive procedures for treating discogenic pain have been reported in recent years. A Disc-FX® system can be used to perform nucleus pulposus (NP) removal, radiofrequency ablation, and annuloplasty under the guidance of x-ray fluoroscopy. However, when a probe tip with focused heat is placed on the intradiscal/subannular area to perform nucleo-annuloplasty using radiofrequency lesioning, thermal injury to the spinal cord or spinal nerves is a concern.
OUTPUT:
|
PubMed_Summ23566 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The spleen and lymph nodes are important functional organs for human immune system. The identification of cell types for spleen and lymph nodes is helpful for understanding the mechanism of immune system. However, the cell types of spleen and lymph are highly diverse in the human body. Therefore, in this study, we employed a series of machine learning algorithms to computationally analyze the cell types of spleen and lymph based on single-cell CITE-seq sequencing data. A total of 28,211 cell data (training vs. test = 14,435 vs. 13,776) involving 24 cell types were collected for this study. For the training dataset, it was analyzed by Boruta and minimum redundancy maximum relevance (mRMR) one by one, resulting in an mRMR feature list. This list was fed into the incremental feature selection (IFS) method, incorporating four classification algorithms (deep forest, random forest, K-nearest neighbor, and decision tree). Some essential features were discovered and the deep forest with its optimal features achieved the best performance. A group of related proteins (CD4, TCRb, CD103, CD43, and CD23) and genes (Nkg7 and Thy1) contributing to the classification of spleen and lymph nodes cell types were analyzed. Furthermore, the classification rules yielded by decision tree were also provided and analyzed. Above findings may provide helpful information for deepening our understanding on the diversity of cell types.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Characterization of spleen and lymph node cell types "
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The spleen and lymph nodes are important functional organs for human immune system. The identification of cell types for spleen and lymph nodes is helpful for understanding the mechanism of immune system. However, the cell types of spleen and lymph are highly diverse in the human body. Therefore, in this study, we employed a series of machine learning algorithms to computationally analyze the cell types of spleen and lymph based on single-cell CITE-seq sequencing data. A total of 28,211 cell data (training vs. test = 14,435 vs. 13,776) involving 24 cell types were collected for this study. For the training dataset, it was analyzed by Boruta and minimum redundancy maximum relevance (mRMR) one by one, resulting in an mRMR feature list. This list was fed into the incremental feature selection (IFS) method, incorporating four classification algorithms (deep forest, random forest, K-nearest neighbor, and decision tree). Some essential features were discovered and the deep forest with its optimal features achieved the best performance. A group of related proteins (CD4, TCRb, CD103, CD43, and CD23) and genes (Nkg7 and Thy1) contributing to the classification of spleen and lymph nodes cell types were analyzed. Furthermore, the classification rules yielded by decision tree were also provided and analyzed. Above findings may provide helpful information for deepening our understanding on the diversity of cell types.
OUTPUT:
|
PubMed_Summ5222 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The outbreak of the COVID-19 pandemic has thus far disrupted clinical nursing education (CNE) around the world and in Iran; which has encountered numerous challenges to this point for students and clinical educators. Therefore, this qualitative study was conducted to identify the perspectives of nursing students and clinical educators during the COVID-19 pandemic.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Clinical nursing education during the COVID-19 pandemic: perspectives of students and clinical educators."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The outbreak of the COVID-19 pandemic has thus far disrupted clinical nursing education (CNE) around the world and in Iran; which has encountered numerous challenges to this point for students and clinical educators. Therefore, this qualitative study was conducted to identify the perspectives of nursing students and clinical educators during the COVID-19 pandemic.
OUTPUT:
|
PubMed_Summ13103 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This paper considers the problem of real-time detection and classification of power quality disturbances in power delivery systems. We propose a sequential and multivariate disturbance detection method (aiming for quick and accurate detection). Our proposed detector follows a non-parametric and supervised approach, i.e., it learns nominal and anomalous patterns from training data involving clean and disturbance signals. The multivariate nature of the method enables joint processing of data from multiple meters, facilitating quicker detection as a result of the cooperative analysis. We further extend our supervised sequential detection method to a multi-hypothesis setting, which aims to classify the disturbance events as quickly and accurately as possible in a real-time manner. The multi-hypothesis method requires a training dataset per hypothesis, i.e., per each disturbance type as well as the 'no disturbance' case. The proposed classification method is demonstrated to quickly and accurately detect and classify power disturbances.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Real-Time Detection and Classification of Power Quality Disturbances."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: This paper considers the problem of real-time detection and classification of power quality disturbances in power delivery systems. We propose a sequential and multivariate disturbance detection method (aiming for quick and accurate detection). Our proposed detector follows a non-parametric and supervised approach, i.e., it learns nominal and anomalous patterns from training data involving clean and disturbance signals. The multivariate nature of the method enables joint processing of data from multiple meters, facilitating quicker detection as a result of the cooperative analysis. We further extend our supervised sequential detection method to a multi-hypothesis setting, which aims to classify the disturbance events as quickly and accurately as possible in a real-time manner. The multi-hypothesis method requires a training dataset per hypothesis, i.e., per each disturbance type as well as the 'no disturbance' case. The proposed classification method is demonstrated to quickly and accurately detect and classify power disturbances.
OUTPUT:
|
PubMed_Summ17566 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Male germ cells are particularly susceptible to radiation; infertility being a common consequence after radiotherapy as it impairs spermatogenesis. This study aimed to test whether treatment with losartan (LOS), a selective antagonist of angiotensin II receptor subtype 1 (AT1R), can prevent or attenuate the acute and long-term radiation-induced damage to testes. Wistar rats were randomly distributed into six groups, three of which were studied on day 2 after irradiation: control (CTRL 2), irradiated non-treated (IR 2), and irradiated and treated with LOS (IRLOS 2); and three other groups that were studied on day 60 after irradiation: control (CTRL 60), irradiated non-treated (IR 60), and irradiated and treated with LOS (IRLOS 60). Seven consecutive days before and on the day of irradiation with 2.5 Gy directly administered in the scrotum, the animals were treated with LOS (34 mg/kg/two times/day). This treatment was continued 2 or 60 days after irradiation. The sperm quality was assessed from epididymis cauda. In addition, the testes were submitted to histopathological and morphometric-stereological analysis as well as the proliferating cell nuclear antigen (PCNA) quantification. Serum FSH and LH and plasma testosterone levels were also determined. The data obtained 2 days after the irradiation showed germ cell apoptosis, formation of vacuoles in the seminiferous epithelium, sloughing of germ cells into the lumen, and retention and phagocytosis of step-19 spermatids in Sertoli basal cytoplasm. The treatment with LOS in this period did not prevent or attenuate a radio-induced damage to the testes, illustrating that this drug does not protect against apoptosis derived from direct effects of radiation. On the other hand, 60 days after exposure, the data evidenced the deleterious effects of ionizing radiation on the testes as decreasing of testicular, epididymal, and seminal vesicle masses; tubular atrophy; reduction of cellular proliferation; and loss of germ cells. LOS was able to prevent some of those deleterious effects, promoting improvements in seminal vesicle mass, sperm vitality, plasma testosterone levels, vacuole number, and cell proliferation. In conclusion, inhibition of the AngII/AT1R axis by LOS is effective in protecting the indirect/delayed radiation damage resulting from oxidative stress established in the tissue.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Losartan Attenuates Radiation-Induced Damage on Testes and Accelerates Tubular Regeneration."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Male germ cells are particularly susceptible to radiation; infertility being a common consequence after radiotherapy as it impairs spermatogenesis. This study aimed to test whether treatment with losartan (LOS), a selective antagonist of angiotensin II receptor subtype 1 (AT1R), can prevent or attenuate the acute and long-term radiation-induced damage to testes. Wistar rats were randomly distributed into six groups, three of which were studied on day 2 after irradiation: control (CTRL 2), irradiated non-treated (IR 2), and irradiated and treated with LOS (IRLOS 2); and three other groups that were studied on day 60 after irradiation: control (CTRL 60), irradiated non-treated (IR 60), and irradiated and treated with LOS (IRLOS 60). Seven consecutive days before and on the day of irradiation with 2.5 Gy directly administered in the scrotum, the animals were treated with LOS (34 mg/kg/two times/day). This treatment was continued 2 or 60 days after irradiation. The sperm quality was assessed from epididymis cauda. In addition, the testes were submitted to histopathological and morphometric-stereological analysis as well as the proliferating cell nuclear antigen (PCNA) quantification. Serum FSH and LH and plasma testosterone levels were also determined. The data obtained 2 days after the irradiation showed germ cell apoptosis, formation of vacuoles in the seminiferous epithelium, sloughing of germ cells into the lumen, and retention and phagocytosis of step-19 spermatids in Sertoli basal cytoplasm. The treatment with LOS in this period did not prevent or attenuate a radio-induced damage to the testes, illustrating that this drug does not protect against apoptosis derived from direct effects of radiation. On the other hand, 60 days after exposure, the data evidenced the deleterious effects of ionizing radiation on the testes as decreasing of testicular, epididymal, and seminal vesicle masses; tubular atrophy; reduction of cellular proliferation; and loss of germ cells. LOS was able to prevent some of those deleterious effects, promoting improvements in seminal vesicle mass, sperm vitality, plasma testosterone levels, vacuole number, and cell proliferation. In conclusion, inhibition of the AngII/AT1R axis by LOS is effective in protecting the indirect/delayed radiation damage resulting from oxidative stress established in the tissue.
OUTPUT:
|
PubMed_Summ17471 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Foaming properties and macromolecular interactions in solution among brewer's spent grain proteins (CP) and iota and lambda carrageenans (i-CG and l-CG, respectively) as a function of aqueous medium pH (2-6) and protein-polysaccharide ratio, R\n OUTPUT:\n "
},
{
"from": "agent",
"value": "Foaming properties are improved by interactions between brewer's spent grain proteins and carrageenans in aqueous solution."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Foaming properties and macromolecular interactions in solution among brewer's spent grain proteins (CP) and iota and lambda carrageenans (i-CG and l-CG, respectively) as a function of aqueous medium pH (2-6) and protein-polysaccharide ratio, R
OUTPUT:
|
PubMed_Summ11251 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The Qinghai-Tibet Plateau (QTP) is known for extreme natural environments and, surprisingly, has been reported to contain widespread organic pollutants. \n OUTPUT:\n "
},
{
"from": "agent",
"value": "Environmental Adaptability and Organic Pollutant Degradation Capacity of a Novel "
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: The Qinghai-Tibet Plateau (QTP) is known for extreme natural environments and, surprisingly, has been reported to contain widespread organic pollutants.
OUTPUT:
|
PubMed_Summ12231 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Prostate cancer (PCa) is characterized by high expression of prostate-specific 1membrane antigen (PSMA), a type II transmembrane protein. Prostate-specific membrane antigen positron emission tomography (PSMA PET) has high sensitivity and specificity and can therefore be potentially used to detect PCa. Exploiting the advantages of PSMA PET imaging, in this study, we aim to develop a novel radiopharmaceutical to facilitate biopsy punching of PCa.\n OUTPUT:\n "
},
{
"from": "agent",
"value": "A Preclinical Study of an "
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Prostate cancer (PCa) is characterized by high expression of prostate-specific 1membrane antigen (PSMA), a type II transmembrane protein. Prostate-specific membrane antigen positron emission tomography (PSMA PET) has high sensitivity and specificity and can therefore be potentially used to detect PCa. Exploiting the advantages of PSMA PET imaging, in this study, we aim to develop a novel radiopharmaceutical to facilitate biopsy punching of PCa.
OUTPUT:
|
PubMed_Summ9683 | [
{
"from": "human",
"value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cognitive impairment often occurs in glioblastoma (GBM) patients due to the tumor itself and treatment side effects. Choline alphoscerate (L-alpha-glycerylphosphorylcholine, GPC) is frequently used to compensate for cognitive impairment in GBM patients. This study was conducted to determine whether GPC affects the overall survival (OS) and progression-free survival (PFS) of GBM patients. From 2011 to 2020, 187 isocitrate dehydrongenase (IDH)-wild-type GBM patients were analyzed. The patients were classified based on whether GPC was continuously used for at least 3 or 12 months (mos) after GBM diagnosis. Although GPC usage (≥3 mos) did not make significant differences in survival extension, median OS in the long-term GPC group (≥12 mos) was longer with statistical significance, compared to the control group (<12 mos) (38.3 vs. 24.0 mos, \n OUTPUT:\n "
},
{
"from": "agent",
"value": "Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study."
}
] | Given an abstract of a biomedical paper, generate the title.
INPUT: Cognitive impairment often occurs in glioblastoma (GBM) patients due to the tumor itself and treatment side effects. Choline alphoscerate (L-alpha-glycerylphosphorylcholine, GPC) is frequently used to compensate for cognitive impairment in GBM patients. This study was conducted to determine whether GPC affects the overall survival (OS) and progression-free survival (PFS) of GBM patients. From 2011 to 2020, 187 isocitrate dehydrongenase (IDH)-wild-type GBM patients were analyzed. The patients were classified based on whether GPC was continuously used for at least 3 or 12 months (mos) after GBM diagnosis. Although GPC usage (≥3 mos) did not make significant differences in survival extension, median OS in the long-term GPC group (≥12 mos) was longer with statistical significance, compared to the control group (<12 mos) (38.3 vs. 24.0 mos,
OUTPUT:
|
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