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[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Metabolic rewiring is a characteristic hallmark of cancer cells. This phenomenon sustains uncontrolled proliferation and resistance to apoptosis by increasing nutrients and energy supply. However, reprogramming comes together with vulnerabilities that can be used against tumor and can be applied in targeted therapy. In the last years, the genetic background of tumors has been identified thoroughly and new therapies targeting those mutations tested. Nevertheless, we propose that targeting the phenotype of cancer cells could be another way of treatment aiming to avoid drug resistance and non-responsiveness of cancer patients. Amino acid metabolism is part of the altered processes in cancer cells. Amino acids are building blocks and also sensors of signaling pathways regulating main biological processes. In this comprehensive review, we described four amino acids (asparagine, arginine, methionine, and cysteine) which have been actively investigated as potential targets for anti-tumor therapy. Asparagine depletion is successfully used for decades in the treatment of acute lymphoblastic leukemia and there is a strong implication to apply it to other types of tumors. Arginine auxotrophic tumors are great candidates for arginine-starvation therapy. Higher requirement for essential amino acids such as methionine and cysteine point out promising targetable weaknesses of cancer cells.\n OUTPUT:\n " }, { "from": "agent", "value": "Targeting amino acid metabolism in cancer." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Tissue inhibitor of metalloproteinase-1 (TIMP-1) levels is strongly associated with cardiac extracellular matrix accumulation and atrial fibrosis. Whether serum levels of TIMP-1 are associated with atrial fibrillation (AF) recurrence following radiofrequency catheter ablation (RFCA) remains unknown.\n OUTPUT:\n " }, { "from": "agent", "value": "Higher serum tissue inhibitor of metalloproteinase-1 predicts atrial fibrillation recurrence after radiofrequency catheter ablation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To review and analyze the efficacy and safety of mifepristone combined with ethacridine lactate for induction of stillbirth in the third trimester.\n OUTPUT:\n " }, { "from": "agent", "value": "Mifepristone combined with ethacridine lactate for third-trimester stillbirth induction: a 5-year experience from Shanghai." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: There are multiple concerns associated with methotrexate (MTX), widely recognized for anti-neoplastic and anti-inflammatory effects in life-threatening disease conditions, i.e., acute lymphoblastic leukemia, non-Hodgkin's lymphoma, psoriasis, and rheumatoid arthritis, due to long-term side effects and associated toxicity, which limits its valuable potential. MTX acts as an inhibitor of dihydrofolate reductase, leading to suppression of purine and pyrimidine synthesis in high metabolic and turnover cells, targeting cancer and dysregulated immune cells. Due to low discrimination between neoplastic cells and naturally high turnover cells, MTX is prone to inhibiting the division of all fast-dividing cells, causing toxicity in multiple organs. Nutraceutical compounds are plant-based or food-derived compounds, used for their preventive and therapeutic role, ascertained in multiple organ dysfunctions, including cardiovascular disease, ischemic stroke, cancer, and neurodegenerative diseases. Gut microbiota and microbiota-derived metabolites take part in multiple physiological processes, their dysregulation being involved in disease pathogenesis. Modulation of gut microbiota by using nutraceutical compounds represents a promising therapeutic direction to restore intestinal dysfunction associated with MTX treatment. In this review, we address the main organ dysfunctions induced by MTX treatment, and modulations of them by using nutraceutical compounds. Moreover, we revealed the protective mechanisms of nutraceuticals in MTX-induced intestinal dysfunctions by modulation of gut microbiota.\n OUTPUT:\n " }, { "from": "agent", "value": "The Protective Effects of Nutraceutical Components in Methotrexate-Induced Toxicity Models-An Overview." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Polyethylenimines (PEIs), a group of polycationic molecules, are known to impair the outer membrane of Gram-negative bacteria and exhibit antimicrobial activity. The outer membrane of Gram-negative strains hinders the uptake of photosensitizer chlorophyllin. In this study, we report chlorophyllin and branched PEI combinations' activity against \n OUTPUT:\n " }, { "from": "agent", "value": "Polyethylenimine Increases Antibacterial Efficiency of Chlorophyllin." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The purpose of this work was to study the effects of substitution of fishmeal by housefly larvae at different rates and different physical states in the diet of local chickens. Five diets consisted of LFD, 25DL, 50DL, 25FL and 50FL, respectively, larval-free, 25%-dried-larvae, 50%-dried-larvae, 25%-fresh-larvae and 50%-fresh-larvae diet, in which 0, 25 and 50% of fishmeal was replaced by dried and fresh larvae, was formulated. A total of 165 local chickens of three weeks old, divided into 15 boxes in batches of 11 animals were raised. The experiment consists of three replications of five treatments. At 14 weeks of age, sixty chickens were slaughtered. Butchery skills and sensory characteristics were evaluated. Thus, a small variation of the ultimate pH from 5.63 to 5.55 between the different types of meat, and a carcass yield around 66%, was recorded. Any effects of substitution rate and physical state of housefly larvae on growth performance was not observed. Feet and proventriculus percentages increased in chickens fed 25% substitution. Liver and spleen percentage, and redder breast meat, increased in chicken fed dried larvae. Yellowness of the breast, thigh-and-drumstick meat and juiciness increased with 50% substitution. There is need of an investigation for liver and spleen enlargement and housefly larvae containing pigments. Thus, housefly larvae up to 50% substitution can be a suitable alternative to fishmeal in local chicken diets.\n OUTPUT:\n " }, { "from": "agent", "value": "Effects of Feeding Housefly (" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Yasmin Foster and Bruce C. Robertson introduce the enigmatic and critically endangered kākāpō - the world's only flightless parrot.\n OUTPUT:\n " }, { "from": "agent", "value": "Kākāpō." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Currently, many small target localization methods based on a magnetic gradient tensor have problems, such as complex solution processes, poor stability, and multiple solutions. This paper proposes an optimization method based on the Euler deconvolution localization method to solve these problems. In a simulation, the Euler deconvolution method, an improved method of the Euler deconvolution method and our proposed method are analyzed under noise conditions. These three methods are evaluated in the field with complex magnetic interference in an experiment. The simulations show that the accuracy of the proposed method is higher than that of the improved Euler deconvolution method and is slightly lower for noisy conditions. The experimental results show that the proposed method is more precise and accurate than the Euler deconvolution and enhanced methods.\n OUTPUT:\n " }, { "from": "agent", "value": "A Small Target Localization Method Based on the Magnetic Gradient Tensor." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The mammalian oviduct is a highly specialized structure where fertilization and early embryonic development occur. Its mucosal epithelium is involved in maintaining and modulating a dynamic intraluminal fluid. The oviductal epithelium consists of ciliated and non-ciliated (secretory) cells whose differentiation and activity are sex hormone-dependent. In this study, we investigated for the first time both the morphology and the glycan composition of baboon oviductal epithelium during the menstrual cycle. Oviducts were laparoscopically removed from 14 healthy adult female \n OUTPUT:\n " }, { "from": "agent", "value": "Modification of Morphology and Glycan Pattern of the Oviductal Epithelium of Baboon " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To study the effect of levilimab or baricitinib in combination with standard therapy (ST) on the incidence of severe viral pneumonia associated with a new coronavirus infection COVID-19.\n OUTPUT:\n " }, { "from": "agent", "value": "[Levilimab and baricitinib prescribing experience in outpatient COVID-19 patients' treatment]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To explore the relation between empathy, belief in a just world, and childhood trauma in pre-clinical medical students.\n OUTPUT:\n " }, { "from": "agent", "value": "Research on the Relationship between Empathy, Belief in a Just World, and Childhood Trauma in Pre-Clinical Medical Students." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Suspension-cultured cells of a bamboo species (Bambusa multiplex; Bm) produce 3-O-feruloylquinic acid (3-FQA) and 3-O-p-coumaroylquinic acid (3-pCQA) by treatment with the histone deacetylase inhibitor suberoyl bis-hydroxamic acid (SBHA). Acyltransferases catalyzing the formation of 5-O-hydroxycinnamoylquinic acid esters by transesterification from hydroxycinnamoyl-CoAs to the C-5 hydroxy group of quinic acid (hydroxycinnamoyl-CoA:quinate hydroxycinnamoyltransferase, HQT) have been identified in the biosynthesis of chlorogenic acids and monolignols; however, an HQT that catalyzes the acylation of the C-3 hydroxy group of quinic acid has not been identified previously. In the present study, we purified a native HQT from SBHA-treated Bm cells. The purified enzyme preferentially accepted feruloyl-/p-coumaroyl-CoAs as acyl-donors and quinic acid as the acyl-acceptor, and the enzyme specifically formed 3-FQA and 3-pCQA but not 5-O-hydroxycinnamoylquinic acid esters or esters with shikimic acid. A cDNA (BmHQT1) encoding this HQT was isolated. Although BmHQT1 is a phylogenetically unique member of the BAHD acyltransferase superfamily that does not cluster with other HQTs, functional characterization of the recombinant enzyme verified that BmHQT1 catalyzes the regiospecific formation of 3-O-hydroxycinnamoylquinic acid esters. Transcript levels of BmHQT1 markedly increased in Bm cells cultured in the presence of SBHA. Moreover, elevated acetylation levels of histone H3 were observed in the coding region of BmHQT1 in the presence of SBHA, indicating that the induced accumulation of 3-FQA/3-pCQA by SBHA is caused by transcriptional activation of BmHQT1 by the action of SBHA as a histone deacetylase inhibitor. The results demonstrate the utility of HDAC inhibitors for discovery of cryptic secondary metabolites and unknown biosynthetic enzymes.\n OUTPUT:\n " }, { "from": "agent", "value": "BAHD acyltransferase induced by histone deacetylase inhibitor catalyzes 3-O-hydroxycinnamoylquinic acid formation in bamboo cells." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The outbreak of the COVID-19 pandemic has thus far disrupted clinical nursing education (CNE) around the world and in Iran; which has encountered numerous challenges to this point for students and clinical educators. Therefore, this qualitative study was conducted to identify the perspectives of nursing students and clinical educators during the COVID-19 pandemic.\n OUTPUT:\n " }, { "from": "agent", "value": "Clinical nursing education during the COVID-19 pandemic: perspectives of students and clinical educators." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: PURPOSE : Intestinal remodeling and adaptation of the alimentary limb after Roux-en-Y gastric bypass (RYGB) play an important role in the pathophysiological events that lead to type 2 diabetes mellitus (T2DM) improvement. Intestinal absorptive loop hypertrophy and growth following surgery have been related to GLP-2 secretion by ileal L-cells. The secretion of peptide tyrosine-tyrosine (PYY) enterohormone after a meal has been proposed as a trigger for ileal secretion of GLP-1. Our aim is to determine the role of PYY as a GLP-2 secretion modulator as an adaptation result in the alimentary limb after RYGB.\n OUTPUT:\n " }, { "from": "agent", "value": "Peptide Tyrosine-Tyrosine Triggers GLP-2-Mediated Intestinal Hypertrophy After Roux-en-Y Gastric Bypass." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Scrotoschisis, also known as extracorporeal testicular ectopia, is an exceedingly rare congenital abnormality that affects the wall of the scrotum. In this condition, the testis exteriorizes through an opening in the anterior scrotal wall. The exact etiology for scrotoschisis is still unknown; however, many theories arose to explain its occurrence. Herein, we report 19th case in the literature in a 2-day-old boy who presented with an eviscerated right testis. We highlighted the possible etiologic hypotheses and management considerations as well.\n OUTPUT:\n " }, { "from": "agent", "value": "Scrotoschisis: An extremely rare scrotal wall anomaly." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Gene duplication plays an important role in evolutionary mechanism, which can act as a new source of genetic material in genome evolution. However, detecting duplicate genes from genomic data can be challenging. Various bioinformatics resources have been developed to identify duplicate genes from single and/or multiple species. Here, we summarize the metrics used to measure sequence identity among gene duplicates within species, compare several computational approaches that have been used to predict gene duplicates, and review recent advancements of a Basic Local Alignment Search Tool (BLAST)-based web tool and database, allowing future researchers to easily identify intra-species gene duplications. This article is a quick reference guide for research tools used for detecting gene duplicates.\n OUTPUT:\n " }, { "from": "agent", "value": "An overview of online resources for intra-species detection of gene duplications." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Mutation in human \n OUTPUT:\n " }, { "from": "agent", "value": "Identification of sensory dysfunction and nervous structure changes in " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: a specific subset of metastatic triple-negative breast cancers (mTNBC) is characterized by homologous recombination deficiency (HRD), leading to enhanced sensitivity to platinum-based chemotherapy. Apart from mutations in \n OUTPUT:\n " }, { "from": "agent", "value": "Alterations in Homologous Recombination-Related Genes and Distinct Platinum Response in Metastatic Triple-Negative Breast Cancers: A Subgroup Analysis of the ProfiLER-01 Trial." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Atypical Parkinson's syndromes are a rare set of neurodegenerative conditions in which a patient experiences the typical symptoms of Parkinson's disease, in addition to various other unrelated issues.\n OUTPUT:\n " }, { "from": "agent", "value": "Acute Worsening of Atypical Parkinson's Syndrome After Receiving Second Dose of Moderna COVID-19 Vaccine." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Efficacy of psychotropic medication depends in large part on successful adherence to prescribed regimens. This study investigated child/youth nonadherence in relation to family dynamics and informal support. The participants were 10,225 children and youth prescribed psychotropic medication and receiving services from 50 Ontario mental health agencies, assessed with the interRAI™ Child and Youth Mental Health (ChYMH) and ChYMH-Developmental Disability (ChYMH-DD) tools. Findings suggest a cycle of parental stress and child/youth medication nonadherence possibly leading to or even perpetuated by worsening psychiatric symptoms. Informal supports do not appear to moderate this cycle. While the present data cannot speak to causes of medication nonadherence in children/youth or where the cycle begins, the results are consistent with the extant literature calling for attention to parental wellbeing to support children/youth for optimal therapeutic benefits. Understanding home dynamics related to nonadherence can assist care planning that engages the family to achieve best possible child/youth outcomes.\n OUTPUT:\n " }, { "from": "agent", "value": "Interrupting the Cycle: Association of Parental Stress and Child/Youth Psychotropic Medication Nonadherence." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Electroencephalography (EEG) is one of the functional brain imaging techniques to effectively measure neuronal activity, but its low spatial resolution makes it difficult to localize evoked excitatory neurons or areas of abnormal firing. Multimodal imaging techniques are expected to combine the high spatial resolution (mm level) of focused ultrasound (FUS) with the high temporal resolution (ms level) of EEG. The technique must be performed under the premise that ultrasound stimulation does not affect neuronal firing, and there is an urgent need to determine the threshold of this ultrasound stimulation parameter.\n OUTPUT:\n " }, { "from": "agent", "value": "Numerical simulation study of firing threshold of STN neuron stimulated by focused ultrasound." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Bacterial resistance represents a major health problem worldwide and there is an urgent need to develop first-in-class compounds directed against new therapeutic targets. We previously developed a drug-discovery platform to identify new antimicrobials able to disrupt the protein-protein interaction between the β' subunit and the σ\n OUTPUT:\n " }, { "from": "agent", "value": "An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Bruton's tyrosine kinase (BTK) is an important protein belonging to the tyrosine kinase family that plays a key role in the intracellular signaling and proliferation, migration, and survival of normal and malignant B-lymphocytes and myeloid cells. Understanding the role of BTK in the B-cell signaling pathway has led to the development of BTK inhibitors (BTKi) as effective therapies for malignancies of myeloid origin and exploration as a promising therapeutic option for other cancers. Given its central function in B-cell receptor signaling, inhibition of BTK is an attractive approach for the treatment of a wide variety of autoimmune diseases that involve aberrant B-cell function including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). Here, we review the role of BTK in different cell signaling pathways, the development of BTKi in B-cell malignancies, and their emerging role in the treatment of MS and other autoimmune disorders.\n OUTPUT:\n " }, { "from": "agent", "value": "Bruton's Tyrosine Kinase Inhibitors: The Next Frontier of B-Cell-Targeted Therapies for Cancer, Autoimmune Disorders, and Multiple Sclerosis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Vicarious racism occurs when hearing about or observing people of the same racial and/or ethnic group experience racism. Healthcare workers may face unique experiences of vicarious racism through witnessing or hearing about racism that their patients and colleagues face. However, there are no validated measures of vicarious racism for the healthcare worker population. In this study, we developed and conducted an initial evaluation of the Vicarious Racism in Healthcare Workers Scale. We developed the 12-item scale based on a qualitative study exploring the experiences of racism among healthcare workers and existing literature on the topic. We administered the scale to a cohort of 259 healthcare workers identifying as a racialized minority to evaluate its factor structure, internal consistency, and construct validity. Factor analysis yielded two factors: racism in social networks and racism in society at-large. This two-factor solution had good model fit (standardized root mean square residual = 0.061). The internal consistencies of the overall scale, social networks subscale, and society subscale were excellent (α = 0.93, 0.92, and 0.89, respectively). We found evidence in support of convergent validity; scale scores were higher among Black healthcare workers compared with non-Black healthcare workers and those with greater social support needs. Scale scores were positively correlated with directly experienced racism and symptoms of posttraumatic stress, depression, and anxiety. The scale demonstrated discriminant validity; scale scores did not differ based on gender or job. The Vicarious Racism in Healthcare Workers Scale demonstrated favorable psychometric properties and may be used to assess vicarious racism in this population.\n OUTPUT:\n " }, { "from": "agent", "value": "Development and Validation of the Vicarious Racism in Healthcare Workers Scale." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Informal waste pickers in cities across the Global South divert significant amounts of tonnage from landfills. This diversion contributes towards a sustainable environment and better public health practices. Informal workers globally derive livelihoods from collecting, sorting, and selling recyclable waste. In South Africa, there is growing recognition of the valuable work that waste pickers carry out. Despite this, however, these informal workers remain largely unrecognised, are often stigmatised, and suffer from a lack of social protection linked to their work. This lack of recognition and protection creates specific occupational hazards for waste pickers. Using an ethnographic method, this study explores the physical and socio-psychological hazards that emerge from waste picking on the streets of the inner city of Durban, in South Africa. We found that the waste pickers, the majority of whom were women, developed mitigation strategies against these risks. A better understanding of how the occupational hazards of waste picking are shaped by the local context of working on the street enables the recognition of the knowledge waste pickers already hold regarding mitigation strategies. Insight into occupational hazards are important to consider if the municipal integration of waste pickers is to happen in a way that ensures access to social protections for these informal workers.\n OUTPUT:\n " }, { "from": "agent", "value": "Working with Waste: Hazards and Mitigation Strategies Used by Waste Pickers in the Inner City of Durban." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Small peptides encoded by long non-coding RNAs (lncRNAs) have attracted attention for their various functions. Recent studies indicate that these small peptides participate in immune responses and antigen presentation. However, the significance of RNA modifications remains unclear.\n OUTPUT:\n " }, { "from": "agent", "value": "Scoring model based on the signature of non-m6A-related neoantigen-coding lncRNAs assists in immune microenvironment analysis and TCR-neoantigen pair selection in gliomas." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Since insulin deficiency results from pancreatic beta-cell destruction, all type 1 and most type 2 diabetes patients eventually require life-long insulin injections. Insulin gene synthesis could also be impaired due to insulin gene mutations as observed in diabetic patients with MODY 10. At this point, insulin gene therapy could be very effective to recompense insulin deficiency under these circumstances. For this reason, an HIV-based lentiviral vector carrying the insulin gene under the control of insulin promoter (LentiINS) was generated, and its therapeutic efficacy was tested in a beta-cell transplant model lacking insulin produced by CRISPR/Cas9-mediated genetically engineered pancreatic beta cells. To generate an insulin knockout beta-cell transplant animal model of diabetes, a dual gene knockout plasmid system involving CRISPR/Cas9 was transfected into a mouse pancreatic beta cell line (Min6). Fluorescence microscopy and antibiotic selection were utilized to select the insulin gene knockout clones. Transplantation of the genetically engineered pancreatic beta cells under the kidney capsule of STZ-induced diabetic rats revealed LentiINS- but not LentiLacZ-infected Ins2KO cells transiently reduced hyperglycemia similar to that of MIN6 in diabetic animals. These results suggest LentiINS has the potential to functionally restore insulin production in an insulin knockout beta-cell transplant animal model of diabetes.\n OUTPUT:\n " }, { "from": "agent", "value": "Generation of a Beta-Cell Transplant Animal Model of Diabetes Using CRISPR Technology." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Non-small cell lung cancer (NSCLC) is one of the most malignant types of cancer with soaring incidence rates worldwide, attributed to its heterogeneity and complex etiology. Evidently, alternative anti-cancer therapies comprising traditional medicines and natural products have gained attention for their ability to act as chemopreventive agents with minimal toxicities, either alone or in combination. Accumulating studies have substantiated the inevitability of network pharmacology studies for effectively mapping molecular targets of natural products against multifaceted diseases, including cancer. The 18α-Glycyrrhetinic acid (18α-GA), a triterpenoid found in licorice plants, has shown promising medicinal properties, although, its mechanism of action against NSCLC yet remains elusive. The present study was conducted to explore the anti- NSCLC potential of 18α-GA, employing integrative network pharmacology, molecular docking, and experimental research. Initially, network analysis revealed 181 common targets of 18α-GA in NSCLC as shown in the \"compound-target- disease\" network employing \n OUTPUT:\n " }, { "from": "agent", "value": "Integrated network pharmacology and experimental analysis unveil multi-targeted effect of 18α- glycyrrhetinic acid against non-small cell lung cancer." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In addition to respiratory symptoms, COVID-19 often causes damage to many other organs, especially in severe forms of the disease. Long-term consequences after COVID-19 are common and often have neurological symptoms. Cerebral vasoreactivity may be impaired after acute COVID-19 and in our study, we wanted to show how constant and reversible are the changes in brain vasoreactivity after infection. This cross-sectional observational study included 49 patients diagnosed with COVID-19 and mild neurological symptoms 300 days after the onset of the disease. We used a transcranial color-coded Doppler (TCCD) and a breath-holding test (BHT) to examine cerebral vasoreactivity and brain endothelial function. We analyzed the parameters of the flow rate through the middle cerebral artery (MCA): peak systolic velocity (PSV), end-diastolic velocity (EDV), mean velocity (MV), resistance index (RI) and pulsatility index (PI), and we calculated the breath-holding index (BHI). Subjects after COVID-19 infection had lower measured velocity parameters through MCA at rest period and after BHT, lower relative increases of flow velocities after BHT, and lower BHI. We showed that subjects, 300 days after COVID-19, still have impaired cerebral vasoreactivity measured by TCCD and they have chronic endothelial dysfunction.\n OUTPUT:\n " }, { "from": "agent", "value": "Chronic Endothelial Dysfunction after COVID-19 Infection Shown by Transcranial Color-Coded Doppler: A Cross-Sectional Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: There is currently little evidence reporting the typical morphology of the palatoglossus (PG) muscle. The primary purpose of this exploratory study is to determine whether magnetic resonance imaging (MRI) methods used to quantify the morphology of the levator veli palatini (LVP) muscle can be applied to the PG. The secondary purpose is to provide preliminary data regarding the relationship between the LVP and PG muscles in children.\n OUTPUT:\n " }, { "from": "agent", "value": "An Exploratory Investigation of the Palatoglossus Muscle in Children Using Magnetic Resonance Imaging." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Eleven world elite ski-mountaineering (Ski-Mo) athletes were evaluated for pronounced echocardiographic physiological remodeling as the primary aim of our feasibility speckle tracking study. In this context, sports-related cardiac remodeling was analyzed by performing two-dimensional echocardiography, including speckle tracking analysis of the left atrium (LA), right ventricle (RV) and left ventricular (LV) global longitudinal strain (LV-GLS) at rest and post-peak performance. The feasibility echocardiographic speckle tracking analysis was performed on eleven elite Ski-Mo athletes, which were obtained in 2022 during the annual medical examination. The obtained data of the professional Ski-Mo athletes (11 athletes, age: 18-26 years) were compared for different echocardiographic parameters at rest and post-exercise. Significant differences were found for LV-GLS mean (\n OUTPUT:\n " }, { "from": "agent", "value": "Left Ventricular, Left Atrial and Right Ventricular Strain Modifications after Maximal Exercise in Elite Ski-Mountaineering Athletes: A Feasibility Speckle Tracking Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study examines the strength development of fly ash-based geopolymer (FAG) as a stabilizer for road base material for pavement construction. In the last decade, there has been a rapid development of conventionally treated bases, such as cement-treated bases. However, a major problem with this kind of application is the shrinkage cracking in cement-treated bases that may result in the reflection cracks on the asphalt pavement surface. This study explores the effects of FAG on base layer properties using mechanistic laboratory evaluation and its practicability in pavement base layers. The investigated properties are flexural strength (FS), unconfined compressive strength (UCS), shrinkage, and resilient modulus (RM), as well as indirect tensile strength (ITS). The findings showed that the mechanical properties of the mixture enhanced when FAG was added to 80-85% of crushed aggregate, with the UCS being shown to be a crucial quality parameter. The effectiveness of FAG base material can have an impact on the flexible pavements' overall performance since the base course stiffness directly depends on the base material properties. As a stabilizing agent for flexible pavement applications, the FAG-stabilized base appeared promising, predicated on test outcomes.\n OUTPUT:\n " }, { "from": "agent", "value": "Mechanical Performance of Fly Ash Based Geopolymer (FAG) as Road Base Stabilizer." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To study the histological variants and mimickers of basal cell carcinoma (BCC) alongwith different risk factors among a group of patients from eastern India.\n OUTPUT:\n " }, { "from": "agent", "value": "Basal cell carcinoma-clinico-pathological study in Eastern India in correlation with different risk factors." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Host immunological pathways are delicate to cope with different types of pathogens. In this article, we divide immunological pathways into two groups: Immunoglobulin G-related eradicable immunities and Immunoglobulin A-related tolerable immunities. Once immune cells encounter an antigen, they can become anergic or trigger immune reactions. Immunoglobulin D B cells and γδ T cells are recognizing self-antigens to become anergic. Immunoglobulin M B cells and αβ T cells can trigger host immune reactions. Eradicable immune responses can be divided into four groups: TH1/TH2/TH22/THαβ (TH-T Helper cell groups). Tolerable immune responses can be divided into four groups: TH1-like/TH9/TH17/TH3. Four groups mean hosts can cope with four types of pathogens. Cancer is related to immune dysfunction. TH1-like immunity is pro-tumor immunity and THαβ is anti-tumor immunity. TH1-like immunity is the host tolerable immunity against intracellular micro-organisms. THαβ immunity is the host eradicable immunity against viruses. Cancer is also related to clonal anergy by Immunoglobulin D B cells and γδ T cells. Oncolytic viruses are related to the activation of anti-viral THαβ immunity. M2 macrophages are related to the tolerable TH1-like immunity, and they are related to metastasis. This review is key to understanding the immune pathogenesis of cancer. We can then develop better therapeutic agents to treat cancer.\n OUTPUT:\n " }, { "from": "agent", "value": "Cancer as a Dysfunctional Immune Disorder: Pro-Tumor TH1-like Immune Response and Anti-Tumor THαβ Immune Response Based on the Complete Updated Framework of Host Immunological Pathways." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The magnitude of the cost of chronic pain has been a matter of concern in many countries worldwide. The high prevalence, the cost it implies for the health system, productivity, and absenteeism need to be addressed urgently. Studies have begun describing this problem in Chile, but there is still a debt in highlighting its importance and urgency on contributing to chronic pain financial coverage. This study objective is to estimate the expected cost of chronic pain and its related musculoskeletal diseases in the Chilean adult population. We conducted a mathematical decision model exercise, Markov Model, to estimate costs and consequences. Patients were classified into severe, moderate, and mild pain groups, restricted to five diseases: knee osteoarthritis, hip osteoarthritis, lower back pain, shoulder pain, and fibromyalgia. Data analysis considered a set of transition probabilities to estimate the total cost, sick leave payment, and productivity losses. Results show that the total annual cost for chronic pain in Chile is USD 943,413,490, corresponding an 80% to the five diseases studied. The highest costs are related to therapeutic management, followed by productivity losses and sick leave days. Low back pain and fibromyalgia are both the costlier chronic pain-related musculoskeletal diseases. We can conclude that the magnitude of the cost in our country's approach to chronic pain is related to increased productivity losses and sick leave payments. Incorporating actions to ensure access and financial coverage and new care strategies that reorganize care delivery to more integrated and comprehensive care could potentially impact costs in both patients and the health system. Finally, the impact of the COVID-19 pandemic will probably deepen even more this problem.\n OUTPUT:\n " }, { "from": "agent", "value": "Cost analysis of chronic pain due to musculoskeletal disorders in Chile." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Traumatic spinal cord injuries (TSCIs) are worldwide public health problems that are difficult to cure and impose a substantial economic burden on society. There has been a lack of extensive multicenter review of TSCI epidemiology in northwest China during the Corona Virus Disease 2019 (COVID-19) pandemic.\n OUTPUT:\n " }, { "from": "agent", "value": "Epidemiological characteristics of traumatic spinal cord injuries in a multicenter retrospective study in northwest China, 2017-2020." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: although onchocerciasis is rarely a life-threatening disease, it causes chronic morbidity which ultimately leads to disability due to late detection and treatment of the infected people. Disability in Onchocerciasis results in activity limitation and social exclusion of the affected individuals through stigma. This study aimed at assessing the level of disability and its determinants among persons with onchocerciasis.\n OUTPUT:\n " }, { "from": "agent", "value": "Disability and its determinants among individuals with onchocerciasis in Southeast Nigeria: a cross-sectional study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: (1) Background: \n OUTPUT:\n " }, { "from": "agent", "value": "Prevalence of " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: With the recent availability and upgrading of many emerging intestinal microbes sequencing technologies, our research on intestinal microbes is changing rapidly. A variety of investigations have found that intestinal microbes are essential for immune system regulation and energy metabolism homeostasis, which impacts many critical organs. The liver is the first organ to be traversed by the intestinal portal vein, and there is a strong bidirectional link between the liver and intestine. Many intestinal factors, such as intestinal microbes, bacterial composition, and intestinal bacterial metabolites, are deeply involved in liver homeostasis. Intestinal microbial dysbiosis and increased intestinal permeability are associated with the pathogenesis of many chronic liver diseases, such as alcoholic fatty liver disease (AFLD), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), chronic hepatitis B (CHB), chronic hepatitis C (CHC), autoimmune liver disease (AIH) and the development of hepatocellular carcinoma (HCC). Intestinal permeability and dysbacteriosis often lead to Lipopolysaccharide (LPS) and metabolites entering in serum. Then, Toll-like receptors activation in the liver induces the exposure of the intestine and liver to many small molecules with pro-inflammatory properties. And all of these eventually result in various liver diseases. In this paper, we have discussed the current evidence on the role of various intestinal microbes in different chronic liver diseases. As well as potential new therapeutic approaches are proposed in this review, such as antibiotics, probiotics, and prebiotics, which may have an improvement in liver diseases.\n OUTPUT:\n " }, { "from": "agent", "value": "Role of Intestinal Microbes in Chronic Liver Diseases." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: HF and osteoporosis shared many common etiological risk factors. However, studies exploring whether patients with HF were associated with a higher risk of osteoporotic fracture resulted in inconsistent findings. This meta-analysis aimed to summarize the association between HF and the risk of incident fracture.\n OUTPUT:\n " }, { "from": "agent", "value": "The association between heart failure and risk of fractures: Pool analysis comprising 260,410 participants." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Selective motor control (SMC) is a fundamental component of typical human motion. As a result of brain damage, impaired SMC often leads to difficulties with coordination, balance, gait efficiency and symmetry.\n OUTPUT:\n " }, { "from": "agent", "value": "Selective motor control correlates with gross motor ability, functional balance and gait performance in ambulant children with bilateral spastic cerebral palsy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This review describes the state of the art in the field of poly (lactic acid) (PLA)-based materials activated by natural compounds and extracts (active ingredients, AIs) from plant sources for food and biomedical applications. With a multidisciplinary approach, after a description of the synthesis and properties of PLA, special attention was paid to the chemical properties and unconventional extraction technologies of AIs used for PLA activation. Innovative techniques for the incorporation of AIs into PLA; characterization and the antioxidant and antimicrobial properties of the novel materials were discussed. In view of future perspectives, this study has evidenced that some aspects need to be further investigated from joint research between academia and industry, according to the green chemistry principles and circular economy strategy.\n OUTPUT:\n " }, { "from": "agent", "value": "Natural Active Ingredients for Poly (Lactic Acid)-Based Materials: State of the Art and Perspectives." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Manganese has excellent performance in removing metal ions from aqueous solutions, but there are few studies on the adsorption and removal of heavy metal impurities in metal salt solutions. In this paper, the adsorption of cobalt and nickel ions in MnSO\n OUTPUT:\n " }, { "from": "agent", "value": "Study on the Adsorption Mechanism of Cobalt and Nickel in Manganese Sulfate by δ-MnO" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In the present work, novel organic-inorganic hybrid materials containing boron, zirconium, and phosphorus were synthesized at different molar ratios, using the sol-gel method, starting from zirconyl chloride hexa-hydrate, triethyl borate, and phenyl phosphonic acid as the precursors. The sol-gel process is used for the first time in the present work in order to obtain organic-inorganic hybrids (or the so-called inorganic polymers) containing together boron, zirconium, and phosphorus. The sol-gel syntheses were performed at room temperature in ethanol. Zirconium containing compounds are already well known for their applications in medicine in restorative or prosthetic devices, including dental implants, knee and hip replacements, middle-ear ossicular chain reconstruction, and so on. Zirconium is a strong transition metal, which started to replace hafnium and titanium in the last decade in important applications. On the other hand, boron has the capability (similar to carbon) to form stable covalently bonded molecular networks. In addition to this capability, boron also offers mixed metallic and nonmetallic properties, because of its place on the periodic table, at the border between metals and nonmetals. Boron is responsible for the higher thermal stability of synthesized hybrid compounds. In the structure of those hybrid compounds, zirconium, boron, and phosphorus atoms are always connected via an oxygen atom, by P-O-Zr, Zr-O-Zr, or Zr-O-B bridges.\n OUTPUT:\n " }, { "from": "agent", "value": "The Influence of Boron on the Structure and Properties of Hybrid Compounds Containing Zirconium and Phosphorus." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Non-destructive testing (NDT) methods are a diagnostic tool for evaluating the risk of failure or the need for repair and renovation. In analyzing constructions of high historical value, destructive diagnostic methods should be avoided. This study is a comprehensive NDT investigation of the masonry tower topped with a steel dome, a remnant of the overhead telecommunications network from the end of the 19th century. Visual inspection and research made it possible to assess the degree of damage to the structure. Stress-strain state analysis showed the sufficient load-bearing capacity of the steel dome. In addition, calculations have shown that the masonry tower is subjected to significant horizontal forces causing structure cracks.\n OUTPUT:\n " }, { "from": "agent", "value": "The Use of NDT Diagnostic Methods and Calculations in Assessing the Masonry Tower Crowned with the Steel Dome." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The traditional nomenclature system for classifying antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) based on clinical phenotype describes granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA) and microscopic polyangiitis (MPA) as distinct clinical entities. This classification has proved its expedience in clinical trials and everyday clinical practice; yet, a substantial overlap in clinical presentation still exists and often causes difficulties in prompt definition and clinical distinction. Additionally, new insights into the AAV pathogenesis point out that PR3 and MPO-AAV may not represent expressions of the same disease spectrum but rather two distinct disorders, as they display significant differences. Thus, it is supported that a classification based on ANCA serotype (PR3-ANCA, MPO-ANCA or ANCA-negative) could be more accurate and also closer to the nature of the disease compared to the phenotype-based one. This review aims to elucidate the major differences between PR3 and MPO-AAV in terms of epidemiology, pathogenesis, histological and clinical manifestations and response to therapeutic approaches.\n OUTPUT:\n " }, { "from": "agent", "value": "Type of ANCA May Be Indispensable in Distinguishing Subphenotypes of Different Clinical Entities in ANCA-Associated Vasculitis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: to construct a prototype of a mobile application on psychological violence against women to facilitate nurses' continuing education.\n OUTPUT:\n " }, { "from": "agent", "value": "\"EMPODEREENF\": construction of an application for nurses' continuing education on psychological violence against women." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Survival rates for extremely low-birth-weight (ELBW) infants are improving as neurodevelopmental impairment (NDI) rates stay stable, thereby increasing the overall number of infants with NDI. Although there are many determinants of NDI in this population, nutritional factors are of interest because they are readily modifiable in the clinical setting. Nurses can influence nutritional factors such as improving access to human milk feeding, using growth monitoring, establishing feeding policies, implementing oral care with colostrum, facilitating kangaroo care, and providing lactation education for the mother. All of these measures assist in leading to a decrease in NDI rates among ELBW infants.\n OUTPUT:\n " }, { "from": "agent", "value": "Nurse-Driven Interventions for Improving ELBW Neurodevelopmental Outcomes." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Detection of extrathyroidal extension (ETE) in patients with papillary thyroid carcinoma (PTC) influences treatment plan and surgical aggressiveness. Ultrasound (US) is the long-standing preoperative imaging method of choice. Recent literature from Asia suggests US accuracy to be influenced by patient characteristics, such as body mass index (BMI). Here, we examine the effect of BMI on the accuracy of US at a North American tertiary referral center. A total of 204 PTC-confirmed patients were retrospectively read by a radiologist blinded to surgical pathology findings. The radiologist recorded multiple sonographic features, including ETE, loss of echogenic capsule, nodule vascularity, capsular abutment, and bulging of contour. When considering all patients, the ultrasonographic feature with the best overall performance was loss of echogenic capsule (diagnostic odds ratio (DOR) = 4.48, 95% confidence interval (CI) = 1.86-10.78). Sub-group analysis by patient BMI found that area under the curve (AUC) for sonographic features was greater in non-obese BMI patients (0.71 ± 0.06) when compared with obese patients (0.43 ± 0.05; \n OUTPUT:\n " }, { "from": "agent", "value": "Diagnostic Accuracy of Ultrasound in Predicting Extrathyroidal Extension and Its Relation to Body Mass Index in a North American Population." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The Hippocratic Oath (the \"Oath\") is a longstanding body of ethical tenets that have undergone several amendments to accommodate changes and evolutions in the practice of medicine. In their recent perspective entitled, \"A Revised Hippocratic Oath for the Era of Digital Health,\" Meskó and Spiegel offered proposed amendments to the Oath to address both challenges and needs that follow digital health implementation in clinical practice. In this commentary, we offer additional thoughts and considerations to Meskó and Spiegel's proposed amendments to accomplish two goals: (1) reflect on the shared goals and values of all digital health stakeholders and (2) drive home the focus on affirming patient choice, autonomy, and respect.\n OUTPUT:\n " }, { "from": "agent", "value": "Practical Considerations and Recommendations for \"a Revised Hippocratic Oath for the Era of Digital Health\"." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Liquid-liquid phase separation (LLPS) has emerged as an important phenomenon associated with formation of membraneless organelles. Recently, LLPS has been shown to act as nucleation centers for disease-associated protein aggregation and amyloid fibril formation. Phase-separated α-synuclein droplets gradually rigidify during the course of protein aggregation, and it is very challenging to understand the biomolecular interactions that lead to liquid-like to solid-like transition using conventional ensemble measurements. Here, we describe a spectrally-resolved fluorescence microscopy based Förster resonance energy transfer (FRET) imaging to probe interactions of α-synuclein in individual droplets during LLPS-mediated aggregation. By acquiring entire emission spectral profiles of individual droplets upon sequential excitation of acceptors and donors therein, this technique allows for the quantification of sensitized emission proportional to the extent of FRET, which enables interrogation of the evolution of local interactions of donor-/acceptor-labeled α-synuclein molecules within each droplet. The present study on single droplets is not only an important development for studying LLPS but can also be used to investigate self-assembly or aggregation in biomolecular systems and soft materials.\n OUTPUT:\n " }, { "from": "agent", "value": "Spectrally Resolved FRET Microscopy of α-Synuclein Phase-Separated Liquid Droplets." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To investigate the effect of monoglyceryl laurate (GML) against PEDV \n OUTPUT:\n " }, { "from": "agent", "value": "Effects of oral of administration of monoglycide laurate on virus load and inflammation in PEDV infected porcine." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cultural landscape heritage refers to the rare and irreplaceable cultural landscapes recognized by UNESCO and the World Heritage Committee. It is recognized as a \"common works of nature and human beings\" of outstanding significance and universal value, and is a type of world heritage. Dueto construction, land isincreasingly limited in urban and rural areasin the process of urbanization, and cultural landscape heritage faces a huge threat, especially larger culturallandscapeheritagelocated at the edgesof cities. However, most of the existing studies have mainly focused on the material protection of heritage but have not paid enough attention to the non-material aspects of heritage sites, failing to reveal the inseparable nature of heritage and land. Therefore, this study takes sustainable development efficiency as its analysis tool, examines two pieces of cultural landscape heritage (the Panlongcheng site and the Tomb of the King of the Ming Dynasty) in the urban edge area of Wuhan, China as examples, innovates and establishes a multidimensional evaluation method based on the GIS-DEA-Ml model, and compares the dynamic changes of the spatial development efficiency and non-spatial development efficiency of the above two cultural landscape heritage cases. The results show that: both the spatial development efficiency and non-spatial development efficiency of Panlongcheng from 2010 to 2019 are significantly higher than that of the Tomb. This method makes up for the deficiency of traditional subjective qualitative analysis. It can be used to study the development efficiency of cultural landscape heritage more objectively and comprehensively, and promote the overall sustainable development of material and intangible cultural heritage. It can provide the basis for early decision-making and post-implementation evaluation for the preservation and utilization of cultural landscape heritage under the background of urban renewal.\n OUTPUT:\n " }, { "from": "agent", "value": "Sustainable Development Efficiency of Cultural Landscape Heritage in Urban Fringe Based on GIS-DEA-MI, a Case Study of Wuhan, China." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Antioxidants are used to prevent oxidation reactions and inhibit the development of unwanted sensory characteristics that decrease the nutritional quality, acceptance, and shelf-life of processed meat products, improving their stability. Synthetic antioxidants, although efficient, are related to the development of diseases because they present toxic and carcinogenic effects. Thus, researchers and the meat industry are studying natural alternatives to synthetic antioxidants to be used in meat products, thus meeting the demand of consumers who seek foods without additives in their composition. These natural extracts have compounds that exert antioxidant activity in different meat products by different mechanisms. Thus, this review work aimed to gather studies that applied natural extracts derived from different plant sources as possible antioxidants in meat products and their action in preserving the quality of these products.\n OUTPUT:\n " }, { "from": "agent", "value": "Addition of Natural Extracts with Antioxidant Function to Preserve the Quality of Meat Products." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Survivorship care plans aim to facilitate a smooth transition from tertiary to primary care settings after primary cancer treatment is completed. This study sought to identify the sociodemographic factors associated with receiving a survivorship care plan and examine the relationship between receiving a plan and confidence in follow-up care delivered by primary care providers. A cross-sectional analysis of the Canadian Partnership Against Cancer's Experiences of Cancer Patients in Transition Study was conducted (n = 9970). Separate adjusted multinomial logistic regression models assessed the relationship between survivorship care plans and follow-up care outcomes. Proportion of survivors more likely to receive a survivorship care plan varied by numerous sociodemographic and medical factors, such as cancer type (colorectal and prostate), gender (male), and education (high school or less). In unadjusted and adjusted models, individuals who received a Survivorship Care Plan had significantly higher odds of: having felt their primary care providers were involved; agreeing that their primary care providers understood their needs, knew where to find supports and services, and were able to refer them directly to services; and were confident that their primary care provider could meet their follow-up care needs.\n OUTPUT:\n " }, { "from": "agent", "value": "The Association between Survivorship Care Plans and Patient-Reported Satisfaction and Confidence with Follow-Up Cancer Care Provided by Primary Care Providers." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: 3q29 microdeletion syndrome (OMIM 609425), first described in 2005, is a rare copy number variation (CNV), accompanied by various neurodevelopmental and psychiatric problems. Phenotypic features of the syndrome have not been fully characterized due to the new definition and rarity. Facial dysmorphology, musculoskeletal anomalies, cardiovascular abnormalities, gastrointestinal abnormalities, and dental abnormalities can be seen.\n OUTPUT:\n " }, { "from": "agent", "value": "3q29 microdeletion syndrome associated with developmental delay and pulmonary stenosis: a case report." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The purpose of this study is to explore two concepts: first, the use of artificial neural networks (ANN) to forecast the base pressure (β) and wall pressure (ω) originating from a suddenly expanded flow field at subsonic Mach numbers. Second, the implementation of Garson approach to determine the critical operating parameters affecting the suddenly expanded subsonic flow process in the subsonic range. In a MATLAB environment, a network model was constructed based on a multilayer perceptron with an input, hidden, and output layer. The network input parameters were the Mach number (M), nozzle pressure ratio (η), area ratio (α), length to diameter ratio (γ), micro jet control (ϵ), and duct location to length ratio (δ). The network output included two variables; base pressure (β) and wall pressure (ω). The ANN was trained and tested using the experimental data. The experimental results found that micro-jet controls were successful in increasing the base pressure for low Mach numbers and high nozzle pressure ratios. It was also found that the wall pressure was same for with and without micro jet control. The ANN predicted values agreed well with the experimental values, with average relative errors of less than 5.02% for base pressure and 6.71% for wall pressure. Additionally, with a relative significance of 32% and 43%, the nozzle pressure ratio and duct location to length ratio had the highest influence on the base pressure and wall pressure, respectively. The results demonstrate that the ANN model is capable of accurately predicting the pressure results, enabling theoretical foundation for research into pressure distribution in aerodynamic systems.\n OUTPUT:\n " }, { "from": "agent", "value": "Investigation of suddenly expanded flows at subsonic Mach numbers using an artificial neural networks approach." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Elucidating the responses and potential functions of soil microbial communities during succession is important for understanding biogeochemical processes and the sustainable development of plant communities after environmental disturbances. However, studies of such dynamics during post-mining ecological restoration in alpine areas remain poorly understood. Microbial diversity, nitrogen, and phosphorus cycle functional gene potential in the Heishan mining area of Northwest China was studied, including primitive succession, secondary succession, and artificial succession disturbed by mining. The results revealed that: (1) The dominant bacteria in both categories (non-remediated and ecologically restored) of mining area rhizosphere soil were Proteobacteria, adopting the r strategy, whereas in naturally occurring soil outside the mining area, the dominant bacteria were actinomycetes and Acidobacteria, adopting the k strategy. Notably, mining perturbation significantly reduced the relative abundance of archaea. (2) After restoration, more bacterial network node connections were observed in mining areas than were originally present, whereas the archaeal network showed the opposite trend. (3) The networks of microbial genes related to nitrogen and phosphorus cycle potential differed significantly, depending on the succession type. Namely, prior to restoration, there were more phosphorus related functional gene network connections; these were also more strongly correlated, and the network was more aggregated. (4) Soil factors such as pH and NO\n OUTPUT:\n " }, { "from": "agent", "value": "Mechanisms underlying the succession of plant rhizosphere microbial community structure and function in an alpine open-pit coal mining disturbance zone." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Reinventing the tetraploid potato into a seed-propagated, diploid, hybrid potato would significantly accelerate potato breeding. In this regard, the development of highly homozygous inbred lines is a prerequisite for breeding hybrid potatoes, but self-incompatibility and inbreeding depression present challenges for developing pure inbred lines. To resolve this impediment, we developed a doubled haploid (DH) technology, based on mutagenesis of the potato \n OUTPUT:\n " }, { "from": "agent", "value": "Construction of homozygous diploid potato through maternal haploid induction." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Metastatic breast cancer (MBC) is an incurable disease and its treatment focuses on prolonging patients' (pts) overall survival (OS) and improving their quality of life. Eribulin is a microtubule inhibitor that increases OS in pre-treated MBC pts. The most common adverse events (AEs) are asthenia, neutropenia and peripheral neuropathy (PN).\n OUTPUT:\n " }, { "from": "agent", "value": "Tolerability of Eribulin and correlation between polymorphisms and neuropathy in an unselected population of female patients with metastatic breast cancer: results of the multicenter, single arm, phase IV PAINTER study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study aimed to analyze the risk factors for dysphagia after \n OUTPUT:\n " }, { "from": "agent", "value": "Analysis of risk factors for postoperative dysphagia after C1-2 fusion." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: INTERGROWTH-21st Newborn Cross-Sectional Study (NCSS) charts were established and recommended for global application. However, whether one international reference is appropriate for all populations is still unclear. We aim to compare the updated Chinese birth size charts by gestational age with INTERGROWTH-21st NCSS charts.\n OUTPUT:\n " }, { "from": "agent", "value": "Comparison of updated birth weight, length and head circumference charts by gestational age in China with the INTERGROWTH-21st NCSS charts: a population-based study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Polymeric microstructures and microchannels are widely used in biomedical devices, optics, microfluidics and fiber optics. The quality, the shape, the spacing and the curvature of microstructure gratings are influenced by different mechanisms and fabrication techniques used. This paper demonstrates a cost-effective way for patterning high-aspect-ratio thermoplastic microstructures using thermal imprint technology and finite element modeling. Polymeric materials polypropylene (PP), polyethylene terephthalate glycol (PETG), polyvinyl chloride (PVC) and styrene-acrylonitrile (SAN) were chosen for the experimental investigations. A finite element model was constructed to define the most suitable parameters (time, heating temperature, pressure, etc.) for the formation of microstructures using the thermal imprint procedure. To confirm the relevance of the finite element model, different types of PP, PETG, PVC and SAN microstructures were fabricated using theoretically defined parameters. Experimental investigations of imprinted microstructures' morphological and optical properties were performed using scanning electron microscopy, atomic force microscopy and a diffractometer. Obtained results confirmed the relevance of the created finite element model which was applied in the formation of high-aspect-ratio microstructures. Application of this model in thermal imprint would not only reduce the fabrication time, but also would highly increase the surface quality and optical properties of the formed structures.\n OUTPUT:\n " }, { "from": "agent", "value": "Development of Finite Element Models of PP, PETG, PVC and SAN Polymers for Thermal Imprint Prediction of High-Aspect-Ratio Microfluidics." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study was to identify factors at the intrapersonal, interpersonal, and community levels that relate to physical leisure participation in Taiwanese community-dwelling older adults and to examine their relative importance. We used a cross-sectional study with purposive sampling (N = 160). Physical leisure participation was quantified as the variety, frequency, and duration of participation. Data were analyzed using a series of hierarchical multiple linear regressions. The results showed that higher variety, frequency, or duration of physical leisure participation was associated with older males and with those who reported having better health, fewer depressive symptoms, and greater social support. Intrapersonal- and interpersonal-level factors play a relatively more important role in predicting physical leisure participation than factors at the community level. Understanding factors that relate to these three levels of participation has the potential to inform interventions that are tailored to individual profiles.\n OUTPUT:\n " }, { "from": "agent", "value": "Factors Associated With Participation in Physical Leisure Activities in Taiwanese Community-Dwelling Older Adults." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The Thai Diagnostic Autism Scale (TDAS) was developed to diagnose autism spectrum disorder (ASD) under the context and characteristics of the Thai population. Although the tool has an excellent agreement, the interpretation of diagnostic results needs to rely on the optimal cut-off point to maximize efficiency and clarity. This study aims to find an optimal cut-off point for TDAS in the diagnosis of ASD and to compare its agreement with the DSM-5 ASD criteria. This study was conducted on 156 children aged 12-48 months old who were suspected of having ASD and had enrolled from hospitals in the four regions of Thailand in 2017-2018. The optimal cut-off point for TDAS was considered by using receiver operating characteristic (ROC) curves according to the DSM-5 ASD criteria. The areas under the curve (AUCs) for TDAS and ADOS-2 were also compared. Multivariable logistic regression was performed to create a predictive model for the probability of ASD. The AUC of TDAS was significantly higher than that of ADOS-2 (0.8748 vs. 0.7993; \n OUTPUT:\n " }, { "from": "agent", "value": "The Optimal Cut-Off Point for Thai Diagnostic Autism Scale and Probability Prediction of Autism Spectrum Disorder Diagnosis in Suspected Children." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This is a fictional case study for training that encourages participants to interact and apply theory into practice. A febrile illness of unknown cause that occurred in Upper Egypt in 2002 was chosen for the events. The location of Aswan was selected to define the climate, topography, and location with the characteristics that support the events. Data obtained from applied research work in Egypt was included. The case study deals with the incidence of severe cases of fever of unknown origin accompanied by neurological and intestinal symptoms, as well as a high percentage of deaths. Most of the symptoms appear in people with direct contact with farm animals especially equines and birds, or those who were near waterways, either tourism workers or tourists. Most of the infected cases or deaths have accumulated in Aswan and some in the neighbouring governorates. This case study focusses on the steps taken during an outbreak investigation, and deals with investigative challenges as well as concepts of biosafety and biosecurity.\n OUTPUT:\n " }, { "from": "agent", "value": "Emergence of a febrile illness of unknown causes among the population and visitors of Upper Egypt." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The Involvement Load Hypothesis (ILH) has become a widely used framework for predicting second language (L2) vocabulary learning from task completion. The purpose of this systematic review was to analyze the predictive ability of the ILH in the acquisition of aspects of knowing a word, its application in different target populations, the effective vocabulary learning task types designed based on the ILH, and the occurrence rate of the ILH components in vocabulary learning tasks. We searched IEEE, ERIC, WOS, Scopus, and ProQuest databases for empirical studies published between 2001 and 2021, using a vocabulary-focused keyword string combined with an ILH-focused keyword string. A total of 78 studies were selected using a set of inclusion and exclusion criteria. The content analysis of these studies showed that researchers have used the ILH to investigate the acquisition of six aspects of knowing a word. Four types of tasks (i.e., fill-in-the-blanks, reading, composition writing, and meaning-inferring) provided more positive evidence for the validation of the ILH. The search component was least present in the vocabulary learning tasks. Researchers have supported the use of the ILH to predict the vocabulary learning potential of tasks completed mainly by adult learners. This systematic review provides direction for future reviews and empirical studies in L2 vocabulary teaching and learning framed by the ILH.\n OUTPUT:\n " }, { "from": "agent", "value": "Empirical Support for the Involvement Load Hypothesis (ILH): A Systematic Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Wellens' syndrome (WS) is a pattern on an electrocardiogram (ECG) characterized by biphasic T waves or deeply inverted T waves in leads V2-V3 with a recent clinical history of angina. Wellens' pattern on the ECG is particular for critical left anterior descending artery (LAD) stenosis. Wellens' sign and WS have been used interchangeably in the literature. However, the typical patterns of ECG changes noted are mostly represented by Wellens' sign. These ECG changes have been crucial in identifying this subset of patients with severe LAD disease.\n OUTPUT:\n " }, { "from": "agent", "value": "Critical Stenosis in Left Anterior Descending Artery: Beware of T- Wave Inversions." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study cross-culturally adapted and psychometrically validated a simplified Chinese version of the Exercise-Induced Leg Pain Questionnaire (SC-EILP) for evaluating the severity of symptoms and sports ability among individuals with exercise-induced leg pain.\n OUTPUT:\n " }, { "from": "agent", "value": "Cross-cultural adaptation and validation of the simplified Chinese version of the Exercise-Induced Leg Pain Questionnaire (EILP)." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Soybean develop a symbiotic relationship with the rhizospheric microbial communities. These organisms are important in maintaining soybean growth and health. Soil samples for this study were collected from Free State, South Africa. We present the microbiome of the soybean rhizosphere and its functional categories at level 1 of the SEED subsystem.\n OUTPUT:\n " }, { "from": "agent", "value": "Microbiome of Soybean (Glycine max L.) Rhizosphere from Free State, South Africa." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Mesenchymal stem cells isolated from the bone marrow have a great differentiation potential, being able to produce many cell lines, including osteoblasts. Osteoblasts have an important role in bone remodeling by actively participating in the maturation and mineralization of the extracellular matrix. The aim of this study was to determine the effect of laser application on the viability and proliferation of osteoblasts.\n OUTPUT:\n " }, { "from": "agent", "value": "Effects of Laser Application on Alveolar Bone Mesenchymal Stem Cells and Osteoblasts: An In Vitro Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: to create and validate a high-fidelity simulation scenario about the initial support to suicide bereaved people.\n OUTPUT:\n " }, { "from": "agent", "value": "Creation and validation of a high-fidelity simulation scenario for suicide postvention." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Chronic obstructive pulmonary disease (COPD) has high morbidity and mortality and presents a threat to human health worldwide. Numerous clinical trials have confirmed that Bufei Yishen formula (BYF), an herbal medicine, can alleviate the symptoms of COPD by reducing oxidative stress-mediated inflammation. However, the active components of BYF remain unclear. We developed an efficient ultrahigh-performance liquid chromatography Q-Extractive Orbitrap mass spectrometry method to identify the composition of BYF and determine its antioxidant profile through an offline screening strategy based on 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH)-liquid chromatography-mass spectrometry. In total, 189 compounds were identified in BYF extract, including 83 flavonoids, 24 lignans, 20 alkaloids, 15 saponins, 11 terpenoid, 10 saccharides, eight lipids, seven organic acids, two coumarins, two amino acids, and seven other compounds. Among them, 79 compounds were found to have a potential antioxidant activity. \n OUTPUT:\n " }, { "from": "agent", "value": "Chemical Identification and Antioxidant Screening of Bufei Yishen Formula using an Offline DPPH Ultrahigh-Performance Liquid Chromatography Q-Extractive Orbitrap MS/MS." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Hydatid cysts can mimic many lung pathologies radiologically, as well as some malignant or benign lung tumors may show hydatid cyst-like radiological features. The aim of our study is to present our clinical experience and recommendations by analyzing the cases that create diagnostic difficulties by presenting a common radiological pattern with a pulmonary hydatid cyst.\n OUTPUT:\n " }, { "from": "agent", "value": "Pitfalls in the surgical treatment of undiagnosed lung lesions and cystic pulmonary hydatidosis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Receptor transporter protein 4 (RTP4), one of the receptor chaperone proteins, contributes to the maturation and membrane trafficking of opioid receptor heteromers consisting of mu (MOPr) and delta (DOPr) opioid receptors (MOPr-DOPr). Although MOPr-DOPr is known to mediate the development of morphine tolerance, the extent to which RTP4 plays a role in this process has not been elucidated. Given that RTP4 can be upregulated by repeated administration of morphine, especially in the hypothalamus, here we investigated the effect of hypothalamus-selective ablation of RTP4 on the development of antinociceptive tolerance to morphine. In this study, we generated <i>RTP4^flox</i> mice and selectively knocked-out RTP4 using local injection of adeno-associated virus expressing Cre recombinase (AAV-Cre) into the hypothalamus. The AAV-Cre injection partially, but significantly, decreased the level of RTP4 expression, and suppressed the development of antinociceptive tolerance to morphine. Next, we examined the mechanism of regulation of RTP4 and found that, in neuronal cells, <i>Rtp4</i> induction is via Gi and MAPK activation, while, in microglial cells, the induction is via Toll-like receptor 4. Together, these studies highlight the role of MOR activity in regulating RTP4, which, in turn, plays an important role in modulating morphine effects in vivo.\n OUTPUT:\n " }, { "from": "agent", "value": "Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Transposable elements (TEs) have been likened to parasites in the genome that reproduce and move ceaselessly in the host, continuously enlarging the host genome. However, the Piwi-interacting RNA (piRNA) pathway defends animal genomes against the harmful consequences of TE invasion by imposing small-RNA-mediated silencing. Here we compare the TE activity of two grasshopper species with different genome sizes in Acrididae (Locusta migratoria manilensis♀1C = 6.60 pg, Angaracris rhodopa♀1C = 16.36 pg) to ascertain the influence of piRNAs.\n OUTPUT:\n " }, { "from": "agent", "value": "Transposable element expansion and low-level piRNA silencing in grasshoppers may cause genome gigantism." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Whole-cell biosensing links the sensing and computing capabilities of microbes to the generation of a detectable reporter. Whole cells enable dynamic biological computation (filtered noise, amplified signals, logic gating etc.). Enzymatic reporters enable \n OUTPUT:\n " }, { "from": "agent", "value": "Enhanced electrochemical measurement of β-galactosidase activity in whole cells by coexpression of lactose permease, LacY." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Efficiently scavenging piezoelectric vibration energy is attracting a lot of interest. One important type is the frequency up-conversion (FUC) energy harvester, in which a low-frequency beam (LFB) impacts a high-frequency beam (HFB). In this paper, four interface circuits, standard energy harvesting (SEH), self-powered synchronous electric charge extraction (SP-SECE), self-powered synchronized switch harvesting on inductor (SP-SSHI) and self-powered optimized SECE (SP-OSECE), are compared while rectifying the generated piezoelectric voltage. The efficiencies of the four circuits are firstly tested at constant displacement and further analyzed. Furthermore, the harvested power under FUC is tested for different electromechanical couplings and different load values. The results show that SP-OSECE performs best in the case of a weak coupling or low-load resistance, for which the maximum power can be 43% higher than that of SEH. As the coupling level increases, SP-SSHI becomes the most efficient circuit with a 31% higher maximum power compared to that of SEH. The reasons for the variations in each circuit with different coupling coefficients are also analyzed.\n OUTPUT:\n " }, { "from": "agent", "value": "Comparison of Four Electrical Interfacing Circuits in Frequency Up-Conversion Piezoelectric Energy Harvesting." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The traditional microlens array imager lacks content information and has low imaging quality when restoring the image of the target, which limits the development of photon integrated detection and imaging technology. Therefore, this paper proposes a new structure of the microlens array optical frequency detection imager, wherein the main microlens array is embedded into the auxiliary microlens array to achieve high-quality restoration of the target. The simulation results show that the proposed structure increased the peak signal-to-noise ratio (P\n OUTPUT:\n " }, { "from": "agent", "value": "Photonic integrated interferometric imaging based on main and auxiliary nested microlens arrays." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The secretion of IgG SARS-CoV-2 antispike antibodies after vaccination with BNT162b2 and the protection represent the response of the human organism to the viral vector symptomatic infections. The aim of the present investigation was to evaluate the immune reaction in health workers of the Polyclinic of Bari to identify the relationship of antispike titers with blood type, sex, age, and comorbidities. This prospective observational study (RENAISSANCE) had as its primary endpoint the assessment of serologic response to BNT162b2 at three blood titers: the first at 60 days after the second dose (3 February 2021); the second titer at 75 days after the first titer; and the third titer at 130 days after the second titer. Out of 230 enrolled staff members, all responded excellently to the mRna Pfizer (BNT162b) vaccine. Only one patient, 40 days after the second dose (3 February 2021), was positive on the swab control performed on 15 March 2021, although completely asymptomatic, and was negative on the subsequent molecular swab performed on 30 March 2021. All the patients responded to the mRNA Pfizer (BNT162b) vaccine with an antispike IgG level above 500 BAU/mL at the first antispike protein essay (60 days after the second dose on 3 April 2021); at the second titer (75 days after the first titer on 20 June 2021), 4 (1.7% of 230 enrolled) patients showed an antispike IgG level under 500 BAU/mL; at the third titer (130 days after the second titer on 30 June 2021, which means 9 months after the second dose), 37 (16.1% of 230 enrolled) patients showed an antispike IgG level under 500 BAU/mL. The data analysis demonstrated that patients belonging to blood group 0, regardless of their rhesus factor, showed the strongest level of antibodies compared to the other groups. No dependency was found between low antibodies level and sex or age. Molecular swab controls were performed every 15th of the month continuously. However, the enrolled patients' activity was at high risk because they carried out medical activities such as dental and surgical as well with droplets of water vaporized by the effect of turbines, piezosurgery. The vaccination campaign among health workers of the Policlinico of the University of Bari \"Aldo Moro\" led to an excellent serological response and the complete absence of COVID-19 incident cases, so the antibody response was excellent. The COVID-19 vaccine booster shot should be administered after 9 months and not without prompt antispike titer detection to assess if any sign of waning immunity is present in that specific patient.\n OUTPUT:\n " }, { "from": "agent", "value": "Antispike Immunoglobulin-G (IgG) Titer Response of SARS-CoV-2 mRNA-Vaccine (BNT162b2): A Monitoring Study on Healthcare Workers." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Polysulfide degradation in wine can result in hydrogen sulfide (H\n OUTPUT:\n " }, { "from": "agent", "value": "Characterization of polysulfides in Saccharomyces cerevisiae cells and finished wine from a cysteine-supplemented model grape medium." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Chlorpyrifos (CP), a widely used pesticide, and its metabolite 3,5,6-trichloro-2-pyridinol (3,5,6-TCP), are xenobiotic compounds detected in many biomes, notably in marine sediments, all over the world. These compounds are posing a serious environmental and health problem given their toxicity to wildlife and possible exposure effects to human neurodevelopment. Microorganisms at CP-impacted environments could harbor metabolic capabilities that can be used as indicators of the biological effects of the contaminant and could encode selected functions reactive against contaminants. Those features could be used for microbial ecotoxicology applications by collectively using analytical, enzymatic, microbiological and toxicological techniques in order to assess the biological effects of pollutants and other environmental/climatic stressors in ecosystems. The objective of this study was to assess the variability in the metabolic responses of yeast isolates from CP-contaminated marine sediments as potential biological indicators for microbial ecotoxicology testing. Sediment samples from a South Caribbean tropical shore (Cartagena Bay, Colombia) were collected, and deoxyribonucleic acid (DNA) was recovered from lyophilized aliquots. The DGGE (Denaturing Gradient Gel Electrophoresis) technique targeting fungal Internal Transcribed Spacer (ITS) showed the great diversity of fungal types. Simultaneously, yeast strains were isolated from the freshly collected sediment samples. Physiological characterization including API 20C and antibiosis tests, growth patterns at salt concentrations (2/4/10/25%), temperatures (4/25/37/45 °C), esterase activity assay and resistance tests to CP/TCP toxicity resulted in 10 isolated yeast strains, identified as \n OUTPUT:\n " }, { "from": "agent", "value": "Towards the Development of Microbial Ecotoxicology Testing Using Chlorpyrifos Contaminated Sediments and Marine Yeast Isolates as a Model." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The quality of work organization may be responsible not only for reduced productivity but also for an increased risk of mental and physical disorders. This study was aimed at testing this hypothesis. Workers of a local health unit in Italy were asked to fill out the Work Organization Assessment Questionnaire (WOAQ) during their periodic medical examinations in the second half of 2018. On the same occasion, they also completed the Demand/Control/Support (DCS) measure of job strain, the Effort/Reward Imbalance (ERI) questionnaire, and the General Health Questionnaire (GHQ12) to assess psychological health. A total of 345 workers (85.8%) completed the survey. Linear regression analysis showed that the quality of work organization was inversely proportional to psychological health problems (\n OUTPUT:\n " }, { "from": "agent", "value": "The Impact of Quality of Work Organization on Distress and Absenteeism among Healthcare Workers." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study aims to investigate the co-movement and Granger causality between Bitcoin prices (BTC) and M2 (cash, demand, and time deposits), inflation, and economic policy uncertainty (EPU) in the U.K. and Japan. It uses monthly data from 31 July 2010 to 30 August 2020 and employs the wavelet coherence method, Toda-Yamamoto, and nonlinear Granger-causality tests. The empirical results show that (i) Bitcoin prices influence M2 and interact with inflation and EPU. In the short term, inflation affects Bitcoin price positively, supporting Bitcoin as an inflation hedged instrument in Japan. Both in Japan and the U.K., the short-term effects of M2 on Bitcoin prices are negative, while EPU's effects on Bitcoin prices are positive, (ii) a bidirectional Toda-Yamamoto Granger causality exists between Bitcoin prices, inflation, and EPU and confirms that M2 affects Bitcoin prices, (iii) a nonlinear bidirectional causality exists between Bitcoin prices and inflation. While Bitcoin prices Granger cause M2 in the U.K. and Japan, inflation shows a nonlinear Granger causality with EPU in Japan. These findings help investors make investment decisions while considering the effects of M2, inflation, and EPU, and monetary authorities and policymakers make policies involving Bitcoin.\n OUTPUT:\n " }, { "from": "agent", "value": "Co-movement and Granger causality between Bitcoin and M2, inflation and economic policy uncertainty: evidence from the U.K. and Japan." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In this article we will present a phenomenological approach to empathy and its relationship with emotions in the context of psychotherapy, highlighting the importance of empathy as a key element of the therapist-client relationship and therapeutic process, regardless of the therapist's approach. We will use a consensus definition of empathy taken from phenomenologically oriented philosophy to analyze therapist's empathy, as well as client's self-empathy and client's empathic communication with others. We will discuss emotions as they usually manifest in the context of psychotherapy, specifically describing how certain emotions can disturb empathic communication in close personal relationships and how it is possible to reestablish empathic communication in psychotherapy. This article it is not only based on evidence from scientific literature but also incorporates the authors' practical knowledge of psychotherapy.\n OUTPUT:\n " }, { "from": "agent", "value": "Phenomenological considerations on empathy and emotions in psychotherapy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Portopulmonary hypertension (POPH) is a condition defined by the development of pulmonary arterial hypertension (PAH) that is associated with liver disease or portal hypertension. Untreated POPH has a poor prognosis. POPH can be treated with PAH-targeted therapy and can sometimes resolve with liver transplantation (LT); however, poorly controlled POPH can preclude LT owing to an increased peri-operative risk. We report a case of POPH that was diagnosed as an unknown atrial septal defect during PAH-targeted therapy. As observed in our case, the same patient may have several causes of PAH. It is important to confirm an unknown shunt disease using echocardiography during PAH-targeted therapy.\n OUTPUT:\n " }, { "from": "agent", "value": "Unknown atrial septal defect was diagnosed during the course of treatment for portopulmonary hypertension: A case report." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Standard echocardiography is vital for the assessment of cardiac performance in healthy and diseased animals. Similarly, two-dimensional speckle-tracking echocardiography (2D-STE) is an advanced echocardiographic technique that is becoming increasingly important for the assessment of myocardial function. Breeds, age, and body weight (BW) are known to be important factors affecting the echocardiographic parameters; therefore, the aim of this study was to evaluate the effect of breed, age, and BW on the echocardiographic parameters in three breeds of clinically healthy Retrievers. A total of 46 Retrievers, including 16 Flat-coated Retrievers (FR), 16 Golden Retrievers (GR), and 14 Labrador Retrievers (LR) were included in the study. The comparison of the breeds revealed significant differences in the LV wall thickness of FR and GR, although further analysis using MLR showed that the differences were most likely associated with BW, similarly to the other LV dimensions. Functional parameters, including ejection fraction, fractional shortening, and left-atrial-to-aortic ratio, were independent of breed, age, and BW. On the other hand, peak aortic blood flow velocity, trans-mitral rapid ventricular filling flow, and the ratio of trans-mitral rapid ventricular filling flow to atrial contraction were influenced by age. The 2D-STE-derived radial and circumferential strain parameters were independent of breed, age, and BW, except for global strain in the radial direction.\n OUTPUT:\n " }, { "from": "agent", "value": "Evaluation of Left Ventricular Function in Healthy Retrievers Using Standard and 2D Speckle-Tracking Echocardiography." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: If a newborn does not pass the first bowel movement within 48 hours, there may be an underlying cause. We describe a rare cause of delayed meconium passage.\n OUTPUT:\n " }, { "from": "agent", "value": "[Delayed meconium passage due to malrotation and colon atresia]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Although the multidimensionality of core discussion networks has been well established and widely studied, studies of the effects of social support on depression rarely consider the multifaceted aspects of dyadic discussion partner ties. This article proposes defining dyadic social relationships as a construct comprising several tie-level attributes and differentiating multiple forms of support relationships by assessing the configuration pattern of multiple attributes. The current study examines various forms of older adults' discussion partners and identifies which form of discussion partner relationship is effective at buffering the negative effects of adverse life events on depression symptoms. Results from the University of California Social Network Survey show that older adults' discussion partners can be classified into five distinct types of dyadic ties: spouse/romantic partners, close neighbors, remote type, social companions, and acquaintances. The discussion network with more close neighbor confidants is more effective at buffering the negative effects of adverse life events. These results offer an alternative way of investigating the differential significance of various social support relationships in mental well-being.\n OUTPUT:\n " }, { "from": "agent", "value": "Different Discussion Partners and Their Effect on Depression among Older Adults." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The oviduct is associated with embryo development and transportation and regulates the pregnancy success of mammals. Previous studies have indicated a molecular mechanism of lncRNAs in gene regulation and reproduction. However, little is known about the function of lncRNAs in the oviduct in modulating goat kidding numbers. Therefore, we combined RNA sequencing (RNA-seq) to map the expression profiles of the oviduct at the luteal phase from high- and low-fecundity goats. The results showed that 2023 differentially expressed mRNAs (DEGs) and 377 differentially expressed lncRNAs (DELs) transcripts were screened, and 2109 regulated lncRNA-mRNA pairs were identified. Subsequently, the genes related to reproduction (\n OUTPUT:\n " }, { "from": "agent", "value": "Oviduct Transcriptomic Reveals the Regulation of mRNAs and lncRNAs Related to Goat Prolificacy in the Luteal Phase." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The Gustave Roussy Immune (GRIm) score is aa prognostic marker in various cancer types. The aim of this study was to investigate the relationship between the GRIm score and short- and long-term outcomes in elderly patients with colon cancer.\n OUTPUT:\n " }, { "from": "agent", "value": "Gustave Roussy Immune Score for Predicting Postoperative Complications and Non-cancer Death in Elderly Patients With Colon Cancer." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Contrast-enhanced neuroimaging is often necessary for the diagnosis and care of patients with diseases of the central nervous system. Although contrast is generally well tolerated and allergy to contrast is rare, allergic reactions can be severe and life threatening. Therefore, physicians should take care to prevent severe contrast allergy. In this review, we will discuss contrast allergy as well as potential strategies to reduce the risk of severe reactions in patients who require neuroimaging techniques with contrast. First, we discuss the clinical presentation and pathogenesis of contrast allergy and the risk factors associated with reactions. We then review methods to reduce the risk of future contrast reactions through improved patient education and documentation strategies, use of alternate imaging modalities or contrast media, premedication, and desensitization.\n OUTPUT:\n " }, { "from": "agent", "value": "Contrast allergies for neurological imaging: When to proceed." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Progress has been made in COVID-19 vaccine development, with encouraging safety and efficacy data. The purpose of this study was to investigate the immunogenicity of inactivated COVID-19 vaccine in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Patients with AIIRD (n = 101) were included in this study. All patients received 2 doses of inactivated COVID-19 vaccine. Serum anti-S1/RBD protein IgG was detected 2-16 weeks after the second vaccination. Seropositivity was defined as IgG ≥ 1.00 bound antibody unit S/CO. Immunogenicity of inactivated COVID-19 vaccine was assessed by seropositivity rate and the levels of serum IgG antibody against anti-S1/RBD protein, compared with the general population (n = 46). There was no difference by statistical significance in the seropositivity rate between patients with AIIRD (82.2%) and SLE (86.1%) and the control group (93.5%), p > 0.05. The level of anti-S1/RBD protein IgG antibodies in patients with AIIRD (median [IQR], 8.8 [2.2-17.3]) and SLE (median [IQR], 9.6 [2.4-20.4]) was comparable to that in the control group (median [IQR], 7.2 [3.1-14.2]), p > 0.05. Patients treated with glucocorticoids(GCs) (median dose, [IQR]: 2.5 mg/day [IQR 2.5-5.0]) or hydroxychloroquine(HCQ) or GCs + HCQ without other immunomodulatory medications, had an appropriate immunogenic response(88.1%) with high levels of anti-S1/RBD protein IgG(median [IQR], 12.1 [6.5-20.4]). Neither of patients treated with rituximab had positive serum antibodies, which was statistically significant, compared with the control group (p < 0.01). Compared with the control group, methotrexate(MTX) and iguratimod(IGU) was significantly reduced the level of anti-S1/RBD protein IgG antibodies. Inactivated COVID-19 vaccine had appropriate immunogenicity in patients with AIIRD. Immunogenicity of inactivated COVID-19 vaccine was severely impaired by rituximab, and also suppressed by MTX and IGU, while low doses of GC and HCQ had negligible effect.\n OUTPUT:\n " }, { "from": "agent", "value": "Immunogenicity of inactivated COVID-19 vaccine in patients with autoimmune inflammatory rheumatic diseases." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Quaternary transition metal cyanamides Na\n OUTPUT:\n " }, { "from": "agent", "value": "Synthetic Engineering in Na" } ]