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PubMed_Summ_train

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[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: How many species are there on Earth and to what groups do these species belong? These fundamental questions span systematics, ecology, and evolutionary biology. Yet, recent estimates of overall global biodiversity have ranged wildly, from the low millions to the trillions. Insects are a pivotal group for these estimates. Insects make up roughly half of currently described extant species (across all groups), with ~1 million described species. Insect diversity is also crucial because many other taxa have species that may be unique to each insect host species, including bacteria, apicomplexan protists, microsporidian fungi, nematodes, and mites. Several projections of total insect diversity (described and undescribed) have converged on ~6 million species. However, these projections have not incorporated the morphologically cryptic species revealed by molecular data. Here, we estimate the extent of cryptic insect diversity. We perform a systematic review of studies that used explicit species-delimitation methods with multi-locus data. We estimate that each morphology-based insect species contains (on average) 3.1 cryptic species. We then use these estimates to project the overall number of species on Earth and their distribution among major groups. Our estimates suggest that overall global biodiversity may range from 563 million to 2.2 billion species. [Biodiversity; cryptic species; insects; species delimitation; species richness].\n OUTPUT:\n " }, { "from": "agent", "value": "Estimating Global Biodiversity: the Role of Cryptic Insect Species." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: (1) The aims of this study were to find out the perception of the coaches of male and female football players in the initiation stage of Spanish professional clubs about different factors of the training process (context, talent development, and methodology), and to identify possible differences according to age/category (U10s: 8-10 years old, and U12s: 10-12 years old) and gender (male and female). (2) For this purpose, a questionnaire of 57 questions grouped into seven dimensions was applied, selecting for this work those related to talent development, training methodology, and social context. A total of 153 coaches from top-level Spanish professional clubs participated in the study: the first and second male division and the first female division. (3) The coaches consider that genetic inheritance is more important than contextual variables in the development of sporting talent. On the other hand, they do not show a clear consensus on whether players who perform better in the initiation stage have a greater chance of reaching the elite. (4) In addition, they value decision-making and technical qualities as fundamental factors in the development of talent rather than physical preparation.\n OUTPUT:\n " }, { "from": "agent", "value": "The Perception of Grassroots Coaches of Spanish Professional Clubs on the Process of Training Young Players." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Radium-223 has been demonstrated in clinical trials to improve survival in castration-resistant prostate cancer (CRPC) patients with bone metastases. However, its performance in routine use remains to be fully characterized. This study aims to describe patient outcomes in the real world as well as identify factors associated with completion of the 6-dose regimen and alkaline phosphatase (ALP) response.\n OUTPUT:\n " }, { "from": "agent", "value": "Outcomes and Factors Associated with Completion of Radium-223 Therapy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In this paper, a milling force prediction model considering the Taylor factor is established, and the Ti-6Al-4V milling force predicted by the model under different milling parameters is presented. In the study, the milling experiment of Ti-6Al-4V was carried out, the milling force was collected by the dynamometer, and the microstructure evolution of the milling surface before and after milling was observed by EBSD. Through the comparative analysis of the experimental results and the model prediction results, the reliability of the prediction model proposed in this study was verified, and the influences of the milling parameters on the milling force were further analyzed. Finally, based on the EBSD observation results, the effects of the milling parameters on the microstructure evolution of the milling surface were studied. The results show that both the tangential milling force and normal milling force increase with the increase in the milling depth and feed rate. Among the milling parameters selected in this study, the milling depth has the greatest influence on the milling force. The average errors of the tangential milling force and normal milling force predicted by the milling force model are less than 10%, indicating that the milling force prediction model established in this paper considering Taylor factor is suitable for the prediction of the Ti-6Al-4V milling force. With the change in the milling parameters, the grain structure, grain size, grain boundary distribution, phase distribution, and micro-texture of the material surface change to varying degrees, and the plastic deformation of the milling surface is largely coordinated by the slip.\n OUTPUT:\n " }, { "from": "agent", "value": "A Ti-6Al-4V Milling Force Prediction Model Based on the Taylor Factor Model and Microstructure Evolution of the Milling Surface." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To improve suitability in applications with high dynamic performance requirements, the transient response characteristics of high-power piezoelectric transducers should be studied quantitatively. This paper proposes the vector reduction method to solve the complex transient equations and obtains a transient matching scheme clarifying the mechanism of electrical matching resistance on electromechanical damping. A matching scheme with a combination of full-bridge inverter, transformer and series LC circuit is designed and validated, which can provide suitable electrical damping without causing energy losses. Consequently, the experiment verifies the transient properties of the proposed scheme. For a typical piezoelectric cutting transducer with 100.8 ms response time, our scheme is verified to have high dynamic performance within frequency response time of 5.5 ms and vibration response time of 15.0 ms.\n OUTPUT:\n " }, { "from": "agent", "value": "Transient Response Characteristics Analysis of High-Power Piezoelectric Transducers." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Nucleic-acid aptamers are of strong interest for diagnosis and therapy. Compared with antibodies, they are smaller, stable upon variations in temperature, easy to modify, and have higher tissue-penetration abilities. However, they have been little described as detection probes in histology studies of human tissue sections. In this study, we performed fluorescence imaging with two aptamers targeting cell-surface receptors EGFR and integrin α5β1, both involved in the aggressiveness of glioblastoma. The aptamers' cell-binding specificities were confirmed using confocal imaging. The affinities of aptamers for glioblastoma cells expressing these receptors were in the 100-300 nM range. The two aptamers were then used to detect EGFR and integrin α5β1 in human glioblastoma tissues and compared with antibody labeling. Our aptafluorescence assays proved to be able to very easily reveal, in a one-step process, not only inter-tumoral glioblastoma heterogeneity (differences observed at the population level) but also intra-tumoral heterogeneity (differences among cells within individual tumors) when aptamers with different specificities were used simultaneously in multiplexing labeling experiments. The discussion also addresses the strengths and limitations of nucleic-acid aptamers for biomarker detection in histology.\n OUTPUT:\n " }, { "from": "agent", "value": "Bioimaging Nucleic-Acid Aptamers with Different Specificities in Human Glioblastoma Tissues Highlights Tumoral Heterogeneity." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The family communication project was a randomized preventive intervention designed to support families by improving interparental conflict behavior and the parent-child relationship, with the ultimate goal of decreasing emotional insecurity in the interparental relationship. Evidence for programs that may benefit father-adolescent attachment and adolescents' emotional insecurity in the marital context is a gap in the literature. According to the fathering vulnerability hypothesis, father-child attachment security might be expected to especially benefit from improvements in interparental conflict behavior. The present study evaluated whether there were any indirect effects of this intervention on emotional insecurity via attachment with each parent, with a particular interest in the role of father-child attachment. Cross-lagged panel models revealed that the parent-adolescent (PA) treatment condition predicted significantly decreased emotional insecurity at 6 months through posttest attachment to fathers, relative to the control and parent-only conditions. Mother-adolescent attachment was improved in the PA condition at posttest but was not a significant mediator of subsequent adolescent emotional insecurity. Thus, the intervention's effects on father-adolescent attachment plays an important role in explaining the long-term effects of the intervention on emotional insecurity about the interparental relationship. Results also call attention to the value of including adolescents in interventions to improve interparental conflict and parent-child relationships. (PsycInfo Database Record (c) 2022 APA, all rights reserved).\n OUTPUT:\n " }, { "from": "agent", "value": "Randomized preventive intervention for families: Adolescents' emotional insecurity and attachment to fathers." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In recent years, during the ravages of COVID-19, a variety of vaccines have been developed and are now on the market. However, although these new vaccines have undergone various trials, there are still many unknown side effects. We report a case of a 30-year-old woman who presented with general weakness, sore throat, generalized skin rashes, symmetrical arthralgia, and persistent fever of up to 40 °C with onset 16 days after receiving the Moderna COVID-19 vaccine. Adult-onset Still's disease (AOSD) was diagnosed according to Yamaguchi's criteria after excluding the feasibility of infectious diseases, autoimmune diseases, and malignancies. In particular, her responses to glucocorticoids and naproxen were significant and inversely proportional to her use of empirical antibiotics in the initial stage of treatment. We studied some similar cases of AOSD, which also considered the adverse effects of COVID-19 vaccination and suggested the immunogenicity and possibility of inflammatory responses related to COVID-19 vaccination.\n OUTPUT:\n " }, { "from": "agent", "value": "Adult-Onset Still's Disease following Coronavirus 2 (SARS-CoV-2) Vaccination: A Case Report." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: l-Kynurenine (Kyn) is an intermediate in the kynurenine pathway and is also found to be a building block or biosynthetic precursor to bioactive natural products. Recent studies revealed that l-Kyn can be incorporated via nonribosomal peptide synthetase (NRPS) biosynthetic routes to generate 1-benzazepine-containing compounds, while 1-benzazepine is a pharmaceutically important scaffold that is rarely found in natural products. Using a core biosynthetic enzyme-guided genome-mining approach, we discovered a biosynthetic gene cluster from \n OUTPUT:\n " }, { "from": "agent", "value": "Genome Mining Discovery of a New Benzazepine Alkaloid Pseudofisnin A from the Marine Fungus " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The study aims to evaluate outpatient satisfaction (OS) with health insurance drug dispensing at the central hospital in Vietnam and to explore the influential factors. A cross-sectional survey was conducted on adult outpatients via an adjusted SERVQUAL questionnaire. The questionnaire's internal consistency (Cronbach alpha) and construct validity (exploratory factor analysis) were considered. The difference between groups was solved using a \n OUTPUT:\n " }, { "from": "agent", "value": "An Assessment of Outpatient Satisfaction with Hospital Pharmacy Quality and Influential Factors in the Context of the COVID-19 Pandemic." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Humans constantly calibrate their sensorimotor system to accommodate environmental changes, and this perception-action integration is extensively studied using sensorimotor adaptation paradigms. The cerebellum is one of the key brain regions for sensorimotor adaptation, but previous attempts to modulate sensorimotor adaptation with cerebellar transcranial direct current stimulation (ctDCS) produced inconsistent findings. Since both conscious/explicit learning and procedural/implicit learning are involved in adaptation, researchers have proposed that ctDCS only affects sensorimotor adaptation when implicit learning dominates the overall adaptation. However, previous research had both types of learning co-exist in their experiments without controlling their potential interaction under the influence of ctDCS. Here, we used error clamp perturbation and gradual perturbation, two effective techniques to elicit implicit learning only, to test the ctDCS effect on sensorimotor adaptation. We administrated ctDCS to independent groups of participants while they implicitly adapted to visual errors. In Experiment 1, we found that cerebellar anodal tDCS had no effect on implicit adaptation induced by error clamp. In Experiment 2, we applied both anodal and cathodal stimulation and used a smaller error clamp to prevent a potential ceiling effect, and replicated the null effect. In Experiment 3, we used gradually imposed visual errors to elicit implicit adaptation but still found no effect of anodal tDCS. With a total of 174 participants, we conclude that the previous inconsistent tDCS effect on sensorimotor adaptation cannot be explained by the relative contribution of implicit learning. Given that the cerebellum is simultaneously involved in explicit and implicit learning, our results suggest that the complex interplay between the two learning processes and large individual differences associated with this interplay might contribute to the inconsistent findings from previous studies on ctDCS and sensorimotor adaptation.\n OUTPUT:\n " }, { "from": "agent", "value": "Transcranial Direct-Current Stimulation Does Not Affect Implicit Sensorimotor Adaptation: A Randomized Sham-Controlled Trial." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Two types of lung cells (epithelial cancer lung cells, A-549 and lung fibroblasts MRC-5) were exposed to the clinically established gold drug auranofin at concentrations close to the half-maximal inhibitory drug concentrations (IC\n OUTPUT:\n " }, { "from": "agent", "value": "Speciation Analysis Highlights the Interactions of Auranofin with the Cytoskeleton Proteins of Lung Cancer Cells." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Superoxide dismutase (SOD) actively participates in the wound stress of plants. However, whether \n OUTPUT:\n " }, { "from": "agent", "value": "Interference Expression of " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: It is critical to thoroughly investigate, characterize, and understand the unique emission profiles of common and novel polymer feedstocks used in fused filament fabrication (FFF) 3D printers as these products become increasingly ubiquitous in consumer and industrial environments. This work contributes unique insights regarding the effects of polymer composite feedstocks with metal, ceramic, or carbonaceous particle additives on particulate emissions in a variety of filaments under various print conditions, including print temperature. In addition to active characterization of particulate size and concentration following the ANSI/CAN/UL 2904 method, particulate sampling and subsequent analysis by scanning electron microscopy revealed agglomeration behavior that may have important health implications. Specifically, fine particles (0.3-2.5 μm) generated by certain filaments including acrylonitrile butadiene styrene (ABS) and glycol-modified poly(ethylene terephthalate) (PETG) are shown to be formed via agglomeration of emitted ultrafine particles rather than composed of coherent primary particles; accordingly, transport and behavior of these particulates after inhalation may not follow expected patterns for micrometer-sized particles. Structures resembling carbonaceous additives (e.g., graphene and nanotubes) were also captured by airborne sampling during printing of filaments containing carbonaceous advanced materials.\n OUTPUT:\n " }, { "from": "agent", "value": "Additives influence 3D printer emission profiles: Implications for working safely with polymer filament composites." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: We develop an innovative framework to study how hoteliers apply inventory control and price discrimination taking into account seasonality. We end up with a time-varying model that, using publicly available information, connects the early booking and last-minute pricing decisions. In doing so, we account for the expected demand size and price elasticity, the inventory put on sales, and the last-minute demand shocks. An analysis focused on 100 hotels in Milan (Italy) shows that during the Covid-19 last-minute discounts/surcharges remain stable over long periods while the role of advance booking as a lever for revenue management is reduced. Moreover, the pandemic has increased the last-minute adjustment at the short advance booking, especially for midweek days.\n OUTPUT:\n " }, { "from": "agent", "value": "Hotel dynamic pricing, stochastic demand and covid-19." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Health Care Workers (HCWs) use Personal Protective Equipment (PPE) during the COVID-19 pandemic to protect themselves and prevent the transmission of the disease. The use of PPE, especially respiratory masks, has adverse consequences, including headaches, which have been secondary and unusual. The aim of the present systematic review and meta-analysis study was to investigate the prevalence of PPE-associated headaches in HCWs during COVID-19 pandemic.\n OUTPUT:\n " }, { "from": "agent", "value": "Personal protective equipment-associated headaches in health care workers during COVID-19: A systematic review and meta-analysis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Institutions sponsoring athletics must be prepared for emergencies. Due to this, more governing bodies are requiring a sports-related emergency action plan (EAP). Yet, the effects of these policies are unknown. We compared adoption of EAPs and associated best practices in Oregon high schools before and after a policy requiring an EAP. Athletic directors were invited to complete a survey during the year before the policy went into effect and again the following year. We assessed whether the school had a written EAP and if they did, was the EAP venue specific, available at the venue, distributed to personnel, and annually reviewed and rehearsed. Pre/post-policy proportions were analyzed using Fisher exact tests for all schools and then schools that completed both surveys. There was a significant increase of schools that reported having an EAP after the policy went into effect (all schools: 55% to 99% [\n OUTPUT:\n " }, { "from": "agent", "value": "The Effect of a Statewide Policy on High School Emergency Action Plans." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This work proposes an augmented reality serious game (ARSG) for supporting individuals with motor disabilities while controlling robotic wheelchairs. A racing track was used as the game narrative; this included restriction areas, static and dynamic virtual objects, as well as obstacles and signs. To experience the game, a prior configuration of the environment, made through a smartphone or a computer, was required. Furthermore, a visualization tool was developed to exhibit user performance while using the ARSG. Two user studies were conducted with 10 and 20 participants, respectively, to compare (1) how different devices enable configuring the ARSG, and (2) different tracking capabilities, i.e., methods used to place virtual content on the real-world environment while the user interacts with the game and controls the wheelchair in the physical space: C1-motion tracking using cloud anchors; C2-offline motion tracking. Results suggest that configuring the environment with the computer is more efficient and accurate, in contrast to the smartphone, which is characterized as more engaging. In addition, condition C1 stood out as more accurate and robust, while condition C2 appeared to be easier to use.\n OUTPUT:\n " }, { "from": "agent", "value": "An Augmented Reality Serious Game for Learning Intelligent Wheelchair Control: Comparing Configuration and Tracking Methods." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT:   The aim of this study is to evaluate whether the treatment of ECC, performed in a single-session dental treatment under general anesthesia, can affect the quality of life of pediatric patients. It was assessed whether risks and discomforts involved in SSGA are outweighed by its effectiveness and reliability in improving oral health-related quality of life.\n OUTPUT:\n " }, { "from": "agent", "value": "Early Childhood Caries and Oral Health-Related Quality of Life: Evaluation of the Effectiveness of Single-Session Therapy Under General Anesthesia." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Spinal cord stimulation (SCS) can improve the level of awareness of prolonged disorder of consciousness (pDOC), but its application is restricted due to damage of invasive operation. Short-term spinal cord stimulation (st-SCS) in a minimally invasive manner will better balance the benefits and risks.\n OUTPUT:\n " }, { "from": "agent", "value": "Effects of short-term spinal cord stimulation on patients with prolonged disorder of consciousness: A pilot study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In this article, we consider a theoretical model for a type I Weyl semimetal, under the presence of a diluted uniform concentration of torsional dislocations. By means of a mathematical analysis for partial wave scattering (phase-shift) for the T-matrix, we obtain the corresponding retarded and advanced Green's functions that include the effects of multiple scattering events with the ensemble of randomly distributed dislocations. Combining this analysis with the Kubo formalism, and including vertex corrections, we calculate the electronic conductivity as a function of temperature and concentration of dislocations. We further evaluate our analytical formulas to predict the electrical conductivity of several transition metal monopnictides, i.e., TaAs, TaP, NbAs, and NbP.\n OUTPUT:\n " }, { "from": "agent", "value": "Electronic Transport in Weyl Semimetals with a Uniform Concentration of Torsional Dislocations." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To investigate the current status of sleep quality and influencing factors of clinical nurses in infectious disease hospitals, and to provide basis and reference for improving their sleep status and providing psychological support.\n OUTPUT:\n " }, { "from": "agent", "value": "Sleep quality status, anxiety, and depression status of nurses in infectious disease department." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Glioblastoma (GBM) is one of the most difficult cancers to treat because GBM has the high therapeutic resistance. Recently, immunotherapies for GBM have been used instead of conventional treatments. Among them, Natural killer (NK) cell-based immunotherapy has the potential to treat GBM due to its properties such as the absence of restriction by antigen-antibody reaction and deep penetration into the tumor microenvironment. Especially, genetically engineered NK cells, such as chimeric antigen receptor (CAR)-NK cells, dual antigen-targeting CAR NK cells, and adapter chimeric antigen receptor NK cells are considered to be an important tool for GBM immunotherapy. Therefore, this review describes the recent efforts of NK cell-based immunotherapy in GBM patients. We also describe key receptors expressing on NK cells such as killer cell immunoglobulin-like receptor, CD16, and natural killer group 2, member D (NKG2DL) receptor and discuss the function and importance of these molecules.\n OUTPUT:\n " }, { "from": "agent", "value": "Natural killer cell immunotherapy in glioblastoma." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In a developing country like the Philippines, it is critical to understand the important factors which lead college students to their current colleges and universities, especially during the COVID-19 pandemic. This study utilized the conjoint analysis approach with an orthogonal design for evaluating understudy's inclination in choosing a college with the various attributes such as the tuition fee, distance or location, employability, academic reputation, recommended by friends and peers, recommended by family or relatives, and the availability to transfer was assessed. A total of 518 Filipino students studying at public and state universities participated in answering the 16 combined attributions about university preference using purposive sampling approach. Based on the utilities estimate, the most important attribute was the tuition fee of the preferred university with an importance value of about 32.839%, followed by the employability rate of the university with about 6% gap difference. The mid-concerned attributes were the distance/location with an estimated of 11.139%, recommendation of friends or peers with approximately 11.689% tying together, and the academic reputation with an estimated of 10.638%. The two least important attributes were identified to be the availability to transfer, having with only about 2.713%, and the recommendation of parents with only 2% difference at approximately 4.453%. The outcomes of this study can aid college chairmen and enrolment specialists tweak their advertising procedures by giving significant data to the chief gatherings engaged with settling college decision choices.\n OUTPUT:\n " }, { "from": "agent", "value": "How important is the tuition fee during the COVID-19 pandemic in a developing country? Evaluation of filipinos' preferences on public university attributes using conjoint analysis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: During the wide utilization of the actinides in medicine, energy, military, and other fields, internal contaminations can profoundly endanger human health and public security. Chelating decorporation agents are the most effective therapies to reduce internal contamination that includes radiological and chemical toxicities. This review introduces the structures of chelating decorporation agents including inorganic salts, polyaminocarboxylic acids, peptides, polyphosphonates, siderophores, calixarenes, polyethylenimines, and fullerenes, and highlights ongoing advances in their designs and mechanisms. However, there are still numerous challenges that block their applications including coordination properties, pharmacokinetic properties, oral bioavailability, limited timing of administration, and toxicity. Therefore, additional efforts are needed to push novel decorporation agents with high efficiency and low toxicity for the treatment of internal contamination by actinides.\n OUTPUT:\n " }, { "from": "agent", "value": "Chelating decorporation agents for internal contamination by actinides: Designs, mechanisms, and advances." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Optic neuritis (ON) is a common manifestation of aquaporin-4 (AQP4) antibody seropositive neuromyelitis optica (NMO). The extent of tissue damage is frequently severe, often leading to loss of visual function, and there is no curative treatment for this condition. To develop a novel therapeutic strategy, elucidating the underlying pathological mechanism using a clinically relevant experimental ON model is necessary. However, previous ON animal models have only resulted in mild lesions with limited functional impairment. In the present study, we attempted to establish a feasible ON model with severe pathological and functional manifestations using a high-affinity anti-AQP4 antibody. Subsequently, we aimed to address whether our model is suitable for potential drug evaluation by testing the effect of minocycline, a well-known microglia/macrophage inhibitor.\n OUTPUT:\n " }, { "from": "agent", "value": "A novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: With the adoption of Epic/Beaker at our institution, surgical pathology specimens are assigned a Current Procedural Terminology (CPT) charge code at the time of accessioning, and pathologists have been made responsible for verifying the accuracy of the code before signing out the case.\n OUTPUT:\n " }, { "from": "agent", "value": "Pathologist-Verified Billing." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Stent thrombosis remains one of the main causes that lead to vascular stent failure in patients undergoing percutaneous coronary intervention (PCI). Type 2 diabetes mellitus is accompanied by endothelial dysfunction and platelet hyperactivity and is associated with suboptimal outcomes following PCI, and an increase in the incidence of late stent thrombosis. Evidence suggests that late stent thrombosis is caused by the delayed and impaired endothelialization of the lumen of the stent. The endothelium has a key role in modulating inflammation and thrombosis and maintaining homeostasis, thus restoring a functional endothelial cell layer is an important target for the prevention of stent thrombosis. Modifications using specific molecules to induce endothelial cell adhesion, proliferation and function can improve stents endothelialization and prevent thrombosis. Blood endothelial progenitor cells (EPCs) represent a potential cell source for the in situ-endothelialization of vascular conduits and stents. We aim in this review to summarize the main biofunctionalization strategies to induce the \n OUTPUT:\n " }, { "from": "agent", "value": "Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Biologic disease-modifying drugs have revolutionised the treatment of a number of chronic inflammatory diseases (CID). However, up to 60% of the patients do not have a sufficient response to treatment and there is a need for optimization of treatment strategies.\n OUTPUT:\n " }, { "from": "agent", "value": "Impact of fibre and red/processed meat intake on treatment outcomes among patients with chronic inflammatory diseases initiating biological therapy: A prospective cohort study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Studies conducted in the health sector have determined a positive relationship between job satisfaction and work engagement. However, this paper reveals that this relationship turns into a negative or non-significant relationship during the COVID-19 pandemic. We explore the reasons for inconsistency in research findings in this critical period through a meta-analysis.\n OUTPUT:\n " }, { "from": "agent", "value": "Counterintuitive consequences of COVID-19 on healthcare workers: A meta-analysis of the relationship between work engagement and job satisfaction." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Spinal cord injury-induced immune deficiency syndrome (SCI-IDS) is a disorder characterized by systemic immunosuppression secondary to SCI that dramatically increases the likelihood of infection and is difficult to treat. T follicular helper (Tfh) cells regulated by chemokine receptor CCR7 are associated with SCI-IDS after acute SCI. The present study explored the roles of CCR7 in SCI-IDS occurrence and immune microenvironment composition. Gene expression profile data of peripheral blood leukocytes from SCI and non-SCI subjects were collected from the Gene Expression Omnibus database. According to differential gene expression analysis, a protein-protein interaction (PPI) network, and risk model construction, the CCR7 expression level was prominently related to acute SCI and CCR7 expression was significantly downregulated after acute SCI. Next, we constructed a clinical prediction model and used it to identify patients with acute SCI. Using Gene Ontology (GO) analysis and gene set enrichment analysis (GSEA), we discovered that immune-related biological processes, such as T cell receptor signaling pathway, were suppressed, whereas chemokine-related signaling pathways were activated after acute SCI. Immune infiltration analysis performed using single sample GSEA and CIBERSORT suggested that Tfh cell function was significantly correlated with the CCR7 expression levels and was considerably reduced after acute SCI. Acute SCI was divided into two subtypes, and we integrated multiple classifiers to analyze and elucidate the immunomodulatory relationships in both subtypes jointly. The results suggested that CCR7 suppresses the immunodeficiency phenotype by activating the chemokine signaling pathway in Tfh cells. In conclusion, CCR7 exhibits potential as a diagnostic marker for acute SCI.\n OUTPUT:\n " }, { "from": "agent", "value": "CCR7-mediated T follicular helper cell differentiation is associated with the pathogenesis and immune microenvironment of spinal cord injury-induced immune deficiency syndrome." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Floccules are another major form of microbial aggregates in aerobic granular sludge systems. Previous studies mainly attributed the persistence of floccules to their relatively faster nutrient uptake and higher growth rate over aerobic granules; however, they failed to unravel the underlying mechanism of the long-term coexistence of these two aggregates. In this work, the existence and function of the floccules in an aerobic granule-dominated sequencing batch reactor were investigated from the view of quorum sensing (QS) and quorum quenching (QQ). The results showed that though the floccules were closely associated with the granules in terms of similar community structures (including the QS- and QQ-related ones), they exhibited a relatively higher QQ-related activity but a lower QS-related activity. A compatible proportion of floccules might be helpful to maintain the QS-related activity and keep the granules stable. In addition, the structure difference was demonstrated to diversify the QS- and QQ-related activities of the floccules and the aerobic granules. These findings could broaden our understanding of the interactions between the coexistent floccules and granules in aerobic granule-dominated systems and would be instructive for the development of the aerobic granular sludge process.\n OUTPUT:\n " }, { "from": "agent", "value": "Quorum sensing unveils the sludge floccule-assisted stabilization of aerobic granules in granule-dominated sequencing batch reactors." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The aim of the present study was to explore \n OUTPUT:\n " }, { "from": "agent", "value": "Exploration of " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Myeloid-derived suppressor cells (MDSCs) are a major immunosuppressive population in the tumor microenvironment,inhibiting anti-tumor immune response and exerting pro-tumorigenic effect. CCAAT/enhancer-binding protein beta (C/EBPβ), a key transcription factor indispensable for myelopoiesis, plays a fundamental role in regulating expansion and activation of MDSCs. Lysine acetylation can regulate functions of transcription factors. However, the role of C/EBPβ acetylation modification in MDSCs has not been reported.\n OUTPUT:\n " }, { "from": "agent", "value": "C/EBPβ enhances immunosuppression activity of myeloid-derived suppressor cells by a P300-mediated acetylation modification." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Interleukin (IL)-34 is a pro-inflammatory cytokine involved in tumor development. The role of IL-34 in the proliferation and epithelial-mesenchymal transition (EMT) of gastric cancer (GC) remains to be investigated.\n OUTPUT:\n " }, { "from": "agent", "value": "Interleukin-34 promotes the proliferation and epithelial-mesenchymal transition of gastric cancer cells." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The reactivation of latent \n OUTPUT:\n " }, { "from": "agent", "value": "Visceral Leishmaniasis after Anti-Interleukin 17A (IL-17A) Therapy in a Patient Affected by Psoriatic Arthritis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Rapid economic development often leads to groundwater degradation, posing health risks to those who rely on it. The groundwater discharge conditions in basins are poor. The health risk of shallow groundwater in basins needs more attentions. The health risk of shallow groundwater in the five basins of Shanxi Province, China was discussed based on the hydrochemical evolution of shallow groundwater and the water quality assessment. The results showed that arsenic (As) and chromium (Cr) in the shallow groundwater of the basins caused prominent health risks followed by fluoride (F) and nitrate (NO\n OUTPUT:\n " }, { "from": "agent", "value": "Health risks of shallow groundwater in the five basins of Shanxi, China: Geographical, geological and human activity roles." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: EMT is a critical cellular phenomenon that promotes tumor invasion and metastasis. Procaine is a local anesthetic agent used in oral surgeries and as an inhibitor of DNA methylation in some types of cancers. In this study, we have investigated whether procaine can inhibit the EMT process in HCC cells and the preclinical model. Procaine suppressed the expression of diverse mesenchymal markers but induced the levels of epithelial markers such as E-cadherin and occludin in HGF-stimulated cells. Procaine also significantly reduced the invasion and migration of HCC cells. Moreover, procaine inhibited HGF-induced c-Met and its downstream oncogenic pathways, such as PI3K/Akt/mTOR and MEK/ERK. Additionally, procaine decreased the tumor burden in the HCC mouse model and abrogated lung metastasis. Overall, our study suggests that procaine may inhibit the EMT process through the modulation of a c-Met signaling pathway.\n OUTPUT:\n " }, { "from": "agent", "value": "Procaine Abrogates the Epithelial-Mesenchymal Transition Process through Modulating c-Met Phosphorylation in Hepatocellular Carcinoma." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: A natural plant product, epigallocatechin-3-gallate (EGCG), was evaluated for its effectiveness in the regulation of osteoclastogenesis. We found that EGCG inhibited the osteoclast (OC) differentiation in vitro, and in primary bone marrow cells in a dose-dependent manner. Quantitative RT-PCR studies showed that the EGCG reduced the expression of OC differentiation markers. DCFDA, MitoSOX, and JC-1 staining revealed that the EGCG attenuated the reactive oxygen species (ROS), and mitochondrial membrane potential; and flux analysis corroborated the effect of EGCG. We further found that the EGCG inhibited mRNA and protein expressions of mitophagy-related molecules. We confirmed that the OC differentiation was inhibited by EGCG by modulating mitophagy through AKT and p38MAPK pathways. Furthermore, in silico analysis revealed that the binding of RANK and RANKL was blocked by EGCG. Overall, we defined the mechanisms of osteoclastogenesis during arthritis for developing a new therapy using a natural compound besides the existing therapeutics.\n OUTPUT:\n " }, { "from": "agent", "value": "Epigallocatechin-3-gallate inhibits osteoclastic differentiation by modulating mitophagy and mitochondrial functions." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The Centers for Disease Control and Prevention has called for an interdisciplinary approach to antibiotic stewardship implementation that includes front-line nurses. The literature to date has identified key factors preventing uptake by nurses: lack of education, poor communication among providers, and unit culture. Three e-learning modules were developed to address the nurses' education regarding the roles nurses play in antibiotic stewardship, antibiotic resistance, allergy assessment, medication side effects and interactions, pharmacokinetics-pharmacodynamics, culture interpretation, specimen collection, and the antibiogram. A survey was used to assess whether nurses felt more prepared to participate after finishing the modules.\n OUTPUT:\n " }, { "from": "agent", "value": "Antibiotic stewardship for nurses: Using e-learning modules to bridge the education gap." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To better understand the purchasing decision-making process of humane pork, and examine the internal relationship between consumers' preferences in rational consumption and irrational decoy scenarios, 405 consumers in Wuxi City, Jiangsu Province, and China were surveyed. Attributes were set for breeding time, breeding mode, diet cleanliness label, and price, and the first three among them reflect animal welfare conditions. The results show that in the rational consumption scenarios, consumers pay the most attention to the price attribute, followed by the attribute of diet cleanliness label, breeding mode, and breeding time. In the irrational decoy scenarios, consumers are most likely to be affected by the attribute decoy of diet cleanliness label, which have the utility of avoiding food safety risks. In addition, the decoy effect triggered by the price attribute which owned the highest degree of rational preference among consumers is also substantially higher, but lower than that of the diet cleanliness label attribute. The decoy effect caused by the breeding time attribute with the lowest degree of consumers' rational preference is also the lowest. Therefore, the government should strengthen the publicity of the humane treatment of pigs before slaughter, and improve the certification and management system of pigs' diet cleanliness. Besides, marketers are suggested to emphasis the product attributes that customer's value the most in their advertising.\n OUTPUT:\n " }, { "from": "agent", "value": "Comparative study on consumers' choice behaviors in selecting pork in rational and irrational scenarios." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Continuous measurement of 98 volatile organic compounds (VOCs) was conducted during 2017-2019 at a regional background site (Shanxi) located at northeast of Zhejiang Province, YRD region, China. The average concentration of total VOCs (TVOCs) was 25.4 ± 18.4 ppbv, and an increasing trend (+12.2 %) was observed. Alkanes were the most abundant VOC group among all seasons, accounting for 43.5 % of TVOCs. Oxygenated VOCs (OVOCs), aromatics, halides and alkenes contributed 15.9 %, 15.7 %, 11.7 % and 10.3 % of TVOCs concentration, respectively. Biogenic VOCs (BVOCs) and OVOCs showed distinguished diurnal cycle from primary anthropogenic VOCs. Photochemical reactivity analysis based on ozone formation potential (OFP) and OH loss rate (L\n OUTPUT:\n " }, { "from": "agent", "value": "Characteristics and sources of ambient Volatile Organic Compounds (VOCs) at a regional background site, YRD region, China: Significant influence of solvent evaporation during hot months." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Terminal differentiation failure is an important cause of rhabdomyosarcoma genesis, however, little is known about the epigenetic regulation of aberrant myogenic differentiation. Here, we show that GATA-4 recruits polycomb group proteins such as EZH2 to negatively regulate miR-29a in undifferentiated C2C12 myoblast cells, whereas recruitment of GRIP-1 to GATA-4 proteins displaces EZH2, resulting in the activation of miR-29a during myogenic differentiation of C2C12 cells. Moreover, in poorly differentiated rhabdomyosarcoma cells, EZH2 still binds to the miR-29a promoter with GATA-4 to mediate transcriptional repression of miR-29a. Interestingly, once re-differentiation of rhabdomyosarcoma cells toward skeletal muscle, EZH2 was dispelled from miR-29a promoter which is similar to that in myogenic differentiation of C2C12 cells. Eventually, this expression of miR-29a results in limited rhabdomyosarcoma cell proliferation and promotes myogenic differentiation. We thus establish that GATA-4 can function as a molecular switch in the up- and downregulation of miR-29a expression. We also demonstrate that GATA-4 acts as a tumor suppressor in rhabdomyosarcoma partly via miR-29a, which thus provides a potential therapeutic target for rhabdomyosarcoma.\n OUTPUT:\n " }, { "from": "agent", "value": "A GRIP-1-EZH2 switch binding to GATA-4 is linked to the genesis of rhabdomyosarcoma through miR-29a." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The increasing incidence of acute appendicitis in sub-Saharan Africa emphasizes the need for accurate and reliable diagnostic tools. However, the variability in the diagnostic performance of computed tomography for suspected acute appendicitis coupled with comparatively higher negative appendectomy rates in this setting highlight a possible concern regarding the diagnostic accuracy. This study evaluated the diagnostic accuracy of a computed tomography scan for suspected acute appendicitis at the emergency department in Tanzania.\n OUTPUT:\n " }, { "from": "agent", "value": "Diagnostic accuracy of computed tomography in adults with suspected acute appendicitis at the emergency department in a private tertiary hospital in Tanzania." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Detecting and recognizing different kinds of urban objects is an important problem, in particular, in autonomous driving. In this context, we studied the potential of Mueller matrix polarimetry for classifying a set of relevant real-world objects: vehicles, pedestrians, traffic signs, pavements, vegetation and tree trunks. We created a database with their experimental Mueller matrices measured at 1550 nm and trained two machine learning classifiers, support vector machine and artificial neural network, to classify new samples. The overall accuracy of over 95% achieved with this approach, with either models, reveals the potential of polarimetry, specially combined with other remote sensing techniques, to enhance object recognition.\n OUTPUT:\n " }, { "from": "agent", "value": "Urban objects classification using Mueller matrix polarimetry and machine learning." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: PARP inhibition in prostate cancer has become a standard-of-care option for men with metastatic castration-resistant prostate cancer (mCRPC) with deficiency in homologous recombination repair (HRRd). The benefit varies based upon the characteristics of the PARP inhibitor used and the underlying HRR defect. Optimal patient selection remains a clinical challenge, and investigations are underway to identify effective combination therapies to expand the population that benefits.\n OUTPUT:\n " }, { "from": "agent", "value": "The evolving landscape of PARP inhibitors in castration-resistant prostate cancer: a spotlight on treatment combinations." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Although the maternal and child health (MCH) Handbook is widely used in many countries, its development and implementation process has not been sufficiently documented in scientific publications. This is a report of how the Angola MCH Handbook was developed, what challenges we encountered during its implementation and how they were solved. Leading the process was the MCH Handbook Committee set up to develop the MCH Handbook and implement the programme in liaison with various stakeholders. We developed the MCH Handbook through participatory workshops with the objective of producing user-responsive content and designs, foster healthy interaction and build common understanding among stakeholders. After pilot use in select health facilities, the MCH Handbook programme, which included training, monitoring and supervision, mothers' class and community awareness raising activities, was gradually implemented in three model provinces. Core members of the committee closely observed each step of the programme to identify challenges in each field, and revised the tool and programme throughout the process. As nationwide implementation of the MCH Handbook Programme progresses, it is important to continually identify challenges specific to different localities while taking measures to address them. In our experience, stakeholder involvement from the early planning and preparation stages was critical to ensure their continued commitment at later stages and for programme continuity. Our approach of tool development involving various stakeholders and flexible implementation strategies were key elements for user acceptance and programme sustainability that may be applicable for introduction of similar interventions in other settings.\n OUTPUT:\n " }, { "from": "agent", "value": "Development and implementation of the maternal and child health Handbook in Angola." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Current dogma is that there exists a hematopoietic pluripotent stem cell, resident in the marrow, which is quiescent, but with tremendous proliferative and differentiative potential. Furthermore, the hematopoietic system is essentially hierarchical with progressive differentiation from the pluripotent stem cells to different classes of hematopoietic cells. However, results summarized here indicate that the marrow pluripotent hematopoietic stem cell is actively cycling and thus continually changing phenotype. As it progresses through cell cycle differentiation potential changes as illustrated by sequential changes in surface expression of B220 and GR-1 epitopes. Further data indicated that the potential of purified hematopoietic stem cells extends to multiple other non-hematopoietic cells. It appears that marrow stem cells will give rise to epithelial pulmonary cells at certain points in cell cycle. Thus, it appears that the marrow \"hematopoietic\" stem cell is also a stem cell for other non-hematopoietic tissues. These observations give rise to the concept of a universal stem cell. The marrow stem cell is not limited to hematopoiesis and its differentiation potential continually changes as it transits cell cycle. Thus, there is a universal stem cell in the marrow which alters its differentiation potential as it progresses through cell cycle. This potential is expressed when it resides in tissues compatible with its differentiation potential, at a particular point in cell cycle transit, or when it interacts with vesicles from that tissue.\n OUTPUT:\n " }, { "from": "agent", "value": "The universal stem cell." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: (1) Background: We aimed to evaluate the health-related quality of life (HRQoL) in children with fractures of the distal forearm and to assess if HRQoL was associated with fracture classification; (2) Methods: We followed up on 432 patients (185 girls, 247 boys) who sustained a fracture of the distal radius or forearm from 1/2007 to 6/2007, 1/2014 to 6/2014, and 11/2016 to 10/2017. Patients filled in the Quick-DASH (primary outcome) and the Peds-QL; (3) Results: The radius was fractured in 429 and the ulna in 175 cases. The most frequent injury of the radius was a buckle fracture (51%, mean age 8.5 years), followed by a complete metaphyseal fracture (22%, 9.5 years), Salter-Harris-2 fracture (14%, 11.4 years), greenstick fracture (10%, 9.3 years), Salter-Harris-1 fracture (1%, 12.6 years), and other rare injuries. The most common treatment was closed reduction and an above-elbow cast in 138 cases (32%), followed by a cast without reduction (30%), splint (28%), and K-wire fixation and cast (9%). Definite treatment was performed initially in 95.8%, a new cast or cast wedging was performed in 1.6%, and revision surgery was performed in 2.5%. There were no open reductions and no plate fixations. After a mean follow-up of 4.2 years, patients with buckle fractures had a mean Quick-DASH of 3.3 (scale of 0-100) (complete fracture: 1.5; greenstick: 1.5; SH-1: 0.9; SH-2: 4.1; others: 0.9). The mean function score of the PedsQL ranged from 93.0 for SH-2 fractures to 97.9 for complete fractures; (4) Conclusions: In this cohort of 432 children with fractures of the distal forearm, there was equally good mean mid- and long-term HRQoL when assessed by the Quick-DASH and the PedsQL. There was a trend for children with complete metaphyseal fractures reporting better HRQoL than patients with buckle fractures or patients with Salter-Harris II fractures, however, these differences were not statistically significant nor clinically relevant.\n OUTPUT:\n " }, { "from": "agent", "value": "Health-Related Quality of Life after Fractures of the Distal Forearm in Children and Adolescents-Results from a Center in Switzerland in 432 Patients." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The aim of this systematic literature review was to determine whether social vulnerability is associated with frailty in older people. Databases were searched for literature from January 2001 to March 2022. Hand searches of reference lists of the selected articles were also used to identify other relevant studies. Studies that met the inclusion criteria were selected. Two independent reviewers assessed the methodological quality using an established tool. Eleven eligible studies from Canada, Europe, USA, Tanzania, Mexico, and China were selected. The level of social vulnerability measured by the Social Vulnerability Index (SVI) from a meta-analysis was 0.300 (95% CI: 0.242, 0.358), with the highest SVI in Tanzania (0.49), while the lowest level of SVI was reported in China (0.15). The highest frailty level of 0.32 was observed in both Tanzania and Europe, with the lowest frailty reported in a USA study from Hawaii (0.15). In all studies, social vulnerability was a significant predictor of mortality for both sexes at subsequent data collection points. The association between SVI and frailty was high in Tanzania (r = 0.81), with other studies reporting stronger correlations for females compared to males, but at small to moderate levels. In one study, an increase of 1SD in SVI was linked to a 20% increase in frailty score at a subsequent evaluation. Additional study is warranted to determine a potential causality between social vulnerability and frailty.\n OUTPUT:\n " }, { "from": "agent", "value": "The Association between Social Vulnerability and Frailty in Community Dwelling Older People: A Systematic Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In order to shed light on unmeasurable real-world phenomena, we investigate exemplarily the actual number of COVID-19 infections in Germany based on big data. The true occurrence of infections is not visible, since not every infected person is tested. This paper demonstrates that coronavirus-related search queries issued on Google can depict true infection levels appropriately. We find significant correlation between search volume and national as well as federal COVID-19 cases as reported by RKI. Additionally, we discover indications that the queries are indeed causal for infection levels. Finally, this approach can replicate varying dark figures throughout different periods of the pandemic and enables early insights into the true spread of future virus outbreaks. This is of high relevance for society in order to assess and understand the current situation during virus outbreaks and for decision-makers to take adequate and justifiable health measures.\n OUTPUT:\n " }, { "from": "agent", "value": "Shedding light on dark figures: Steps towards a methodology for estimating actual numbers of COVID-19 infections in Germany based on Google Trends." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This article describes the various forms of inflammatory lesions of the aorta and large arteries, including chronic periaortitis, as well as the diagnostic methods are considered. Large vessel vasculitis represent the most common entities, however, there is also an association with other rheumatological or inflammatory diseases, drug-induced or paraneoplastic entities. Instrumental imaging modalities play an important role in the diagnosis.\n OUTPUT:\n " }, { "from": "agent", "value": "[Non-infectious diseases of the aorta and large arteries]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Invasive hemodynamic variables obtained from right heart catheterization have been used for risk-stratifying patients with advanced heart failure (HF). However, there is a paucity of data on the prognostic value of invasive hemodynamic variables in patients with left ventricular assist devices (LVAD). We hypothesized that cardiac power output (CPO), cardiac power efficiency (CPE), and left ventricular stroke work index (LVSWI) can serve as prognostic markers in patients with LVADs.\n OUTPUT:\n " }, { "from": "agent", "value": "The prognostic role of advanced hemodynamic variables in patients with left ventricular assist devices." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cardiovascular disease is the leading cause of death globally among non-communicable diseases, which imposes a serious socioeconomic burden on patients and the healthcare system. Therefore, finding new strategies for preventing and treating cardiovascular diseases is of great significance in reducing the number of deaths and disabilities worldwide. Dipeptidyl peptidase 3 (DPP3) is the first zinc-dependent peptidase found among DPPs, mainly distributes within the cytoplasm. With the unique HEXXGH catalytic sequence, it is associated with the degradation of oligopeptides with 4 to 10 amino acids residues. Accumulating evidences have demonstrated that DPP3 plays a significant role in almost all cellular activities and pathophysiological mechanisms. Regarding the role of DPP3 in cardiovascular diseases, it is currently mainly used as a biomarker for poor prognosis in patients with cardiovascular diseases, suggesting that the level of DPP3 concentration in plasma is closely linked to the mortality of diseases such as cardiogenic shock and heart failure. Interestingly, it has been reported recently that DPP3 regulates blood pressure by interacting with the renin-angiotensin system. In addition, DPP3 also participates in the processes of pain signaling, inflammation, and oxidative stress. But the exact mechanism by which DPP3 affects cardiovascular function is not clear. Hence, this review summarizes the recent advances in the structure and catalytic activity of DPP3 and its extensive biological functions, especially its role as a therapeutic target in cardiovascular diseases. It will provide a theoretical basis for exploring the potential value of DPP3 as a therapeutic target for cardiovascular diseases.\n OUTPUT:\n " }, { "from": "agent", "value": "DPP3: From biomarker to therapeutic target of cardiovascular diseases." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Programmed reduction of synapses is a hallmark of the developing brain, with sensory systems emerging as useful models with which to study this pruning. The central projections (terminal field) of the gustatory glossopharyngeal nerve (GL) of the rat are a prime example of developmental pruning, undergoing an approximate 66% reduction in volume from postnatal day 15 (P15) to P25. Later in adulthood, developmental GL pruning can be experimentally reversed, expanding to preweaning volumes, suggesting mature volumes may be actively maintained throughout the life span. Microglia are central nervous system glia cells that perform pruning and maintenance functions in other sensory systems, including other gustatory nerves. To determine their role in GL pruning, we depleted microglia from Sprague-Dawley rat brains from P1 to P40 using daily intraperitoneal injections of the colony-stimulating factor 1 receptor inhibitor PLX5622. This prevented GL developmental pruning, resulting in preweaning terminal field volumes and innervation patterns persisting through P40, 2 weeks after pruning is normally completed. These findings show microglia are necessary for developmental GL pruning. Ceasing PLX5622 treatments at P40 allowed microglia repopulation, and within 4 weeks the GL terminal field had reduced to control volumes, indicating that pruning can occur outside of the typical developmental period. Conversely, when microglia were depleted in adult rats, GL terminal fields expanded, reverting to sizes comparable to the neonatal rat. These data indicate that microglia are required for GL pruning and may continue to maintain the GL terminal field at a reduced size into adulthood.\n OUTPUT:\n " }, { "from": "agent", "value": "Terminal field volume of the glossopharyngeal nerve in adult rats reverts to prepruning size following microglia depletion with PLX5622." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The breakthrough of a limited number of clones while on immune checkpoint inhibitors (ICIs), known as oligoprogression, has been previously described. The benefit of ablative radiation therapy (RT) directed at these clones, as opposed to changing systemic therapy, is unclear. We analyzed 30 patients with advanced solid tumors, the majority of whom (23/30, 86.7%) had either hepatocellular or urothelial carcinoma, who experienced oligoprogression on ICIs and were referred for RT. In this study, oligoprogression was defined as having experienced progression at three or fewer metastatic sites outside of the brain after achieving at least stable disease on ICIs for a minimum of three months. The median time to oligoprogression was 11.1 months from the initiation of immunotherapy. 24 patients had one oligoprogressive lesion and six had two. The median radiation dose delivered was 4650 cGy in a median of five fractions. The median progression-free survival (PFS) after RT was 7.1 months, and the time to oligoprogression was not a significant predictor of PFS2. 26 patients continued on ICIs after RT. While 17 patients subsequently progressed, 15 did so at three or fewer metastatic sites and could have theoretically stood to benefit from an additional course of salvage RT to further extend the lifespan of their ICIs. Overall survival at 6, 12, and 24 months was 100.0%, 96.3%, and 82.8%, respectively. These results suggest that RT may provide a PFS benefit and extend the lifespan of ICIs in patients who experience oligoprogression. Regardless of PFS, however, overall survival in this population appears to be excellent.\n OUTPUT:\n " }, { "from": "agent", "value": "Oligoprogression of Solid Tumors on Immune Checkpoint Inhibitors: The Impact of Local Ablative Radiation Therapy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The aim of this article was to open a hatch to the consumer psychology research through the eyes of Facet Theory. The Facet Theory enables to delve into a concept or an issue under investigation and define it formally, systematically, and comprehensively, but still parsimoniously. In order to better explain its philosophical basis and the principles of this theory, we apply and demonstrate it on the domain of marketing of higher education to students. There are four distinct facets identified in this regard, namely, (A) Achieving Personal Goals, (B) Institution's Marketing Orientation, (C) Secondary Decision Criteria, and (D) Level of Education. Based on those facets and their related respective elements, a suggested definitional directive for the marketing of higher education to students is construed.\n OUTPUT:\n " }, { "from": "agent", "value": "A systematic and theoretical approach to the marketing of higher education." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The cornerstone of nanomaterial-based sensing systems is the synthesis of nanoparticles with appropriate surface functionalization that ensures their stability and determines their reactivity with organic or inorganic analytes. To accomplish these requirements, various compounds are used as additives or growth factors to regulate the properties of the synthesized nanoparticles and their reactivity with the target analytes. A different rationale is to use the target analytes as additives or growth agents to control the formation and properties of nanoparticles. The main difference is that the analyte recognition event occurs before or during the formation of nanoparticles and it is based on the reactivity of the analytes with the precursor materials of the nanoparticles (e.g., metal ions, reducing agents, and coatings). The transition from the ionic (or molecular) state of the precursor materials to ordered nanostructured assemblies is used for sensing and signal transduction for the qualitative detection and the quantitative determination of the target analytes, respectively. This review focuses on assays that are based on analyte-mediated regulation of nanoparticles' formation and differentiate them from standard nanoparticle-based assays which rely on pre-synthesized nanoparticles. Firstly, the principles of analyte-mediated nanomaterial sensors are described and then they are discussed with emphasis on the sensing strategies, the signal transduction mechanisms, and their applications. Finally, the main advantages, as well as the limitations of this approach, are discussed and compared with assays that rely on pre-synthesized nanoparticles in order to highlight the major advances accomplished with this type of nano-sensors and elucidate challenges and opportunities for further evolving new nano-sensing strategies.\n OUTPUT:\n " }, { "from": "agent", "value": "Analyte-mediated formation and growth of nanoparticles for the development of chemical sensors and biosensors." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Single nucleotide polymorphism is known to alter the expression and processing of miRNAs leading to a variety of diseases including rheumatoid arthritis (RA). However, disagreement is present up to date regarding the association of miRNA-146a and miRNA-499 polymorphisms with RA. The goal of this study was to assess the association of polymorphisms at miRNA-146a and miRNA-499 with the pathogenesis of RA in patients originating from Pakistan. Initially, eleven hundred subjects (1100) comprises of 550 RA patients and 550 healthy controls were investigated in the case-control analysis. Spectrophotometric measurement of lipids and C-reactive protein was used, whereas interleukin-1 receptor associated kinase-1 and TNF-receptor associated factor-6 values were quantified by an enzyme-linked immunosorbent assay. Secondly, heritability of susceptible alleles was tested from 70 trio-families. The miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms were genotyped using the polymerase chain reaction followed by restriction digestion. A Significant association of miRNA-146a and miRNA-499 genotypes was observed with RA patients (P < 0.05, respectively). The miRNA-146a rs2910164 G (OR = 1.4, P < 0.05) and miRNA-499 rs3746444 C (OR = 1.6, P < 0.0001) allele was significantly associated with RA in comparison with controls, respectively. Besides, the transmission analysis revealed a significant (P < 0.05) inheritance of rs2910164 G and rs3746444 C allele from parents to affected offspring. The current research concludes that miRNA-146a (rs2910164; C > G) and miRNA-499 (rs3746444; T > C) polymorphisms are linked to RA in the population studied. Furthermore, it was demonstrated for the first time in our high-risk cohort that the rs2910164 G and rs3746444 C allele was strongly related to familial RA.\n OUTPUT:\n " }, { "from": "agent", "value": "Association analysis of miRNA-146a and miRNA-499 polymorphisms with rheumatoid arthritis: a case-control and trio-family study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This case involved a 6-year-old boy with Down syndrome, left C1 lateral mass hypertrophy, C1-2 rotatory subluxation, and spinal cord compression. He presented after falling down some stairs at his home. Torticollis, dysphagia, and speech delay were noted on examination. Vascular imaging showed impingement on the left vertebral artery by the anomalous C1 lateral mass. Through a posterior approach, the hypertrophic C1 lateral mass was resected, and an occiput-C2 fusion was performed. Postoperatively, his torticollis and brainstem symptoms were resolved. The video can be found here: https://youtu.be/1U0GLdw6c70.\n OUTPUT:\n " }, { "from": "agent", "value": "C1 hypertrophic lateral mass resection and occiput-C2 fusion." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Diseases that affect the liver account for approximately 2 million deaths worldwide each year. The increasing prevalence of these diseases and the limited efficacy of current treatments are expected to stimulate substantial growth in the global market for therapeutics that target the liver. Currently, liver transplantation is the only curative option available for many liver diseases. Gene therapy represents a valuable approach to treatment. The liver plays a central role in a myriad of essential metabolic functions, making it an attractive organ for gene therapy; hepatocytes comprise the most relevant target. To date, viral vectors constitute the preferred approach to targeting hepatocytes with genes of therapeutic interest. Alternatively, mRNA-based therapy offers a number of comparative advantages. Clinical and preclinical studies undertaken to treat inherited metabolic diseases affecting the liver, cirrhosis and fibrosis, hepatocellular carcinoma, hepatitis B, and cytomegalovirus using lipid nanoparticle-encapsulated mRNAs that encode the therapeutic or antigenic protein of interest are discussed.\n OUTPUT:\n " }, { "from": "agent", "value": "mRNA-Based Approaches to Treating Liver Diseases." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Slope stability is one of the biggest concerns for mining practices and to consider the rock mass response over blasting is fundamental to achieve pit geometry. This study consists in developing a methodology which connects the dynamic behavior of one lithological domain to blast designs applied at a copper mine. The central element of this study was the construction of vibration attenuation and seed wave model which, in conjunction with geomechanical properties, has allowed the characterization of this particular rock mass and the vibration attenuation phenomena. The new blast design was developed from the model simulations, once it was possible to recognize which parameters of the blast design affect most of the damage induced by blasting. To guarantee model representativeness, two blast tests were conducted: one with the usual blast design and another using the new one. Furthermore, holes were drilled behind the blasts, which were inspected before and after each blast to compare the produced fracturing with the fracturing expected by the model. The results obtained in these blast tests show a strong correlation between the modeled and the real. The modeling proved to be a useful tool providing manners to stablish a blast design, which generates stable walls.\n OUTPUT:\n " }, { "from": "agent", "value": "Correlating blast vibrations and geomechanical properties to determine damage profiles and improve wall conditions in open pit mining." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Soccer is the world's game, and keeping athletes healthy while playing the game has often been a focus of study. There is a high occurrence of musculoskeletal injuries reported in soccer. FIFA 11+ was developed as an intervention to help prevent such injuries. FIFA 11+ has previously been studied for its efficacy as an injury prevention program, but not for its effect on sports performance in an adolescent population. The purpose of this study was to look at the effect of implementing the FIFA 11+ intervention on strength, speed, and agility. Twenty youth soccer players were randomly divided into an intervention group (INT) and a control group (CON). The intervention lasted for eight weeks and performance assessments were completed pre- and post-intervention. Post-test INT knee flexor strength was significantly higher than pre-test scores (\n OUTPUT:\n " }, { "from": "agent", "value": "The Effect of FIFA 11+ on the Isometric Strength and Running Ability of Young Soccer Players." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In addition to autoimmune and inflammatory diseases, variants of the TNFAIP3 gene encoding the ubiquitin-editing enzyme A20 are also associated with fibrosis in systemic sclerosis (SSc). However, it remains unclear how genetic factors contribute to SSc pathogenesis, and which cell types drive the disease due to SSc-specific genetic alterations. We therefore characterize the expression, function, and role of A20, and its negative transcriptional regulator DREAM, in patients with SSc and disease models. Levels of A20 are significantly reduced in SSc skin and lungs, while DREAM is elevated. In isolated fibroblasts, A20 mitigates ex vivo profibrotic responses. Mice haploinsufficient for A20, or harboring fibroblasts-specific A20 deletion, recapitulate major pathological features of SSc, whereas DREAM-null mice with elevated A20 expression are protected. In DREAM-null fibroblasts, TGF-β induces the expression of A20, compared to wild-type fibroblasts. An anti-fibrotic small molecule targeting cellular adiponectin receptors stimulates A20 expression in vitro in wild-type but not A20-deficient fibroblasts and in bleomycin-treated mice. Thus, A20 has a novel cell-intrinsic function in restraining fibroblast activation, and together with DREAM, constitutes a critical regulatory network governing the fibrotic process in SSc. A20 and DREAM represent novel druggable targets for fibrosis therapy.\n OUTPUT:\n " }, { "from": "agent", "value": "Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In recent years, the concept of cell heterogeneity in biology has gained increasing attention, concomitant with a push toward technologies capable of resolving such biological complexity at the molecular level. For single-cell proteomics using Mass Spectrometry (scMS) and low-input proteomics experiments, the sensitivity of an orbitrap mass analyzer can sometimes be limiting. Therefore, low-input proteomics and scMS could benefit from linear ion traps, which provide faster scanning speeds and higher sensitivity than an orbitrap mass analyzer, however at the cost of resolution. We optimized an acquisition method that combines the orbitrap and linear ion trap, as implemented on a tribrid instrument, while taking advantage of the high-field asymmetric waveform ion mobility spectrometry (FAIMS) pro interface, with a prime focus on low-input applications. First, we compared the performance of orbitrap- versus linear ion trap mass analyzers. Subsequently, we optimized critical method parameters for low-input measurement by data-independent acquisition on the linear ion trap mass analyzer. We conclude that linear ion traps mass analyzers combined with FAIMS and Whisper flow chromatography are well-tailored for low-input proteomics experiments, and can simultaneously increase the throughput and sensitivity of large-scale proteomics experiments where limited material is available, such as clinical samples and cellular subpopulations.\n OUTPUT:\n " }, { "from": "agent", "value": "High Sensitivity Limited Material Proteomics Empowered by Data-Independent Acquisition on Linear Ion Traps." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Asthma is a chronic disease of the airways characterized by inflammation, tightened muscles, and thickened airway walls leading to symptoms such as shortness of breath, chest tightness, and cough in patients. The increased risk of asthma in children of asthmatics parents supports the existence of genetic factors involved in the pathogenesis of this disease. Genome-wide association studies have discovered several single nucleotide polymorphisms associated with asthma. These polymorphisms occur within several genes and can contribute to different asthma phenotypes, affect disease severity, and clinical response to different therapies. The complexity in the etiology of asthma also results from interactions between environmental and genetic factors. Environmental exposures have been shown to increase the prevalence of asthma in individuals who are genetically susceptible. This review summarizes what is currently known about the genetics of asthma in relation to risk, response to common treatments, and gene-environmental interactions.\n OUTPUT:\n " }, { "from": "agent", "value": "The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Technological meat quality and sensory attributes of fresh and frozen lamb meat were compared. Samples were collected from two abattoirs (one small-scale, one large-scale) that use different slaughter methods in terms of chilling regime and electrical stimulation. The fresh and frozen meat samples included products from both slaughter systems. Ten twin pairs of ram lambs were used in the study, with one of each twin slaughtered at each abattoir. Fresh meat was analysed after chilling and frozen meat was stored frozen for three months and analysed after thawing. The \n OUTPUT:\n " }, { "from": "agent", "value": "A Comparison of Fresh and Frozen Lamb Meat-Differences in Technological Meat Quality and Sensory Attributes." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In neuropathic pain following peripheral nerve injury, microglia are rapidly activated and accumulated in the spinal cord. Physical exercise can alleviate neuropathic pain. However, the exact mechanism underlying this analgesic effect is not fully understood.\n OUTPUT:\n " }, { "from": "agent", "value": "Exercise Facilitates the M1-to-M2 Polarization of Microglia by Enhancing Autophagy via the BDNF/AKT/mTOR Pathway in Neuropathic Pain." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Endophytic bacteria are plant-beneficial bacteria with a broad host range. They provide numerous benefits to their hosts, helping them tolerate several biotic and abiotic stresses. An interest has recently been developed in endophytic bacteria which are producing bioactive compounds that contribute to the biological control of various phytopathogens. This research paper aimed to investigate the potentiality of new local strains of endophytic bacteria such as \n OUTPUT:\n " }, { "from": "agent", "value": "Evaluation of the Antifungal Activity of " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: SUMO modification is a vital post-translational regulation process in eukaryotes, in which the SUMO protease is responsible for the maturation of the SUMO precursor and the deconjugation of the SUMO protein from modified proteins by accurately cleaving behind the C-terminal Gly-Gly motif. To promote the understanding of the high specificity of the SUMO protease against the SUMO protein as well as to clarify whether the conserved Gly-Gly motif is strictly required for the processing of the SUMO precursor, we systematically profiled the specificity of the \n OUTPUT:\n " }, { "from": "agent", "value": "Profiling Substrate Specificity of the SUMO Protease Ulp1 by the YESS-PSSC System to Advance the Conserved Mechanism for Substrate Cleavage." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Coxsackievirus A16 (CVA16) is well known for causing hand-foot-and-mouth disease (HFMD) and outbreaks were frequently reported in Taiwan in the past twenty years. The epidemiology and genetic variations of CVA16 in Taiwan from 1998 to 2021 were analyzed in this study. CVA16 infections usually occurred in early summer and early winter, and showed increased incidence in 1998, 2000-2003, 2005, 2007-2008, and 2010 in Taiwan. Little or no CVA16 was detected from 2017 to 2021. CVA16 infection was prevalent in patients between 1 to 3 years old. A total of 69 isolates were sequenced. Phylogenetic analysis based on the VP1 region showed that CVA16 subgenotype B1 was dominantly isolated in Taiwan from 1998 to 2019, and B2 was identified only from isolates collected in 1999 and 2000. There was a high frequency of synonymous mutations in the amino acid sequences of the VP1 region among CVA16 isolates, with the exception of position 145 which showed positive selection. The recombination analysis of the whole genome of CVA16 isolates indicated that the 5'-untranslated region and the non-structural protein region of CVA16 subgenotype B1 were recombined with Coxsackievirus A4 (CVA4) and enterovirus A71 (EVA71) genotype A, respectively. The recombination pattern of subgenotype B2 was similar to B1, however, the 3D region was similar to EVA71 genotype B. Cross-neutralization among CVA16 showed that mouse antisera from various subgenotypes viruses can cross-neutralize different genotype with high neutralizing antibody titers. These results suggest that the dominant CVA16 genotype B1 can serve as a vaccine candidate for CVA16.\n OUTPUT:\n " }, { "from": "agent", "value": "Genetic and Cross Neutralization Analyses of Coxsackievirus A16 Circulating in Taiwan from 1998 to 2021 Suggest Dominant Genotype B1 can Serve as Vaccine Candidate." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Several systematic reviews evaluating the use of telemedicine by clinicians, patients, and health authorities to improve the delivery of care in the 53 member states of the World Health Organization (WHO) European Region have been conducted in recent years. However, a study summarizing the findings of these reviews has not been conducted.\n OUTPUT:\n " }, { "from": "agent", "value": "The Current Status of Telemedicine Technology Use Across the World Health Organization European Region: An Overview of Systematic Reviews." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Flavonoids were biotransformed using various microorganisms, in order to obtain new compounds with potentially high biological activity. The aim of this work was to determine and compare the biological activity of four novel 6-methylflavanone \n OUTPUT:\n " }, { "from": "agent", "value": "Novel " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study aimed to develop a consensus framework for economic evaluations of vaccines as a national guideline in China. Some unique and important aspects were particularly emphasized. Nineteen Chinese experts in the field of health economics and immunization decision-making were nominated to select and discuss relevant aspects of vaccine economic evaluations in China. A workshop attended by external experts was held to summarize unique and important aspects and formulate consensus recommendations. There were ten unique and/or important aspects identified for economic evaluations of vaccines in China, including study perspectives, comparator strategies, analysis types, model choices, costing approaches, utility measures, discounting, uncertainty, equity, and evaluation purposes. Background information and expert recommendations were provided for each aspect. Economic evaluations of vaccines should play an important role in China's immunization policy-making. This guideline can help improve the quality of economic evaluations as a good practice consensus.\n OUTPUT:\n " }, { "from": "agent", "value": "A guideline for economic evaluations of vaccines and immunization programs in China." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Radio-iodine refractory (RAI-R) differentiated thyroid cancer (DTC) is a rare disease with a poor prognosis and limited therapeutic resources. Therefore, identifying prognostic factors is essential in order to select patients who could benefit from an early start of treatment. The aim of this study is to identify positron emission tomography with 18F-fluorodeoxyglucose with integrated computed tomography (18F-FDG-PET/CT) parameters to predict overall survival (OS) in patients with RAI-R DTC. In this single-center retrospective study, we analyze the 18F-FDG-PET/CT parameters of 34 patients with RAI-R DTC between April 2007 and December 2019. The parameters collected are MTV, SUVmax and progression for each site of metastasis (neck, mediastinum, lungs, liver, bone) and total sites. ROC curves, Kaplan-Meier survival analysis curves, univariate and multivariate Cox analyses determine prognostic factors for 1-year and 5-year OS. The parameters for mediastinum, liver and total sites are significantly associated with worse 1-year and 5-year OS by both ROC curve analysis and Kaplan-Meier survival analysis. Univariate Cox analysis confirms significance of mediastinum SUVmax (HR 1.08; 95% CI [1.02-1.15]; \n OUTPUT:\n " }, { "from": "agent", "value": "Using 18F-FDG-PET/CT Metrics to Predict Survival in Ra-Dio-Iodine Refractory Thyroid Cancers." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The resting membrane potential of most cells is maintained by potassium K2p channels. The pharmacological profile and distribution of various K2p channel subtypes in organisms are still being investigated. The Drosophila genome contains 11 subtypes; however, their function and expression profiles have not yet been determined. Doxapram is clinically used to enhance respiration in humans and blocks the acid-sensitive K2p TASK subtype in mammals. The resting membrane potential of larval Drosophila muscle and synaptic transmission at the neuromuscular junction are pH sensitive. The present study investigated the effects of doxapram on membrane potential and synaptic transmission using intracellular recordings of larval Drosophila muscles. Doxapram (1 mM and 10 mM) depolarizes the muscle and appears to depolarize motor neurons, causing an increase in the frequency of spontaneous quantal events and evoked excitatory junction potentials. Verapamil (1 and 10 mM) paralleled the action of doxapram. These changes were matched by an extracellular increase in KCl (50 mM) and blocked by Cd\n OUTPUT:\n " }, { "from": "agent", "value": "The effects of doxapram (blocker of K2p channels) on resting membrane potential and synaptic transmission at the Drosophila neuromuscular junction." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Exercise-induced fatigue is a multi-origin physical and mental phenomenon. Efforts to diminish the above predisposition may contribute to endurance, along with athletic well-being, while development of nutritional strategies to optimize condition and exercise performance are essential issues for athletes and trainers. Dietary amino acids are being discussed for their specific health-promoting properties beyond their role as building blocks of proteins. Glutamine, along with cysteine, are two kinds of amino acids that are reported extensively for their anti-oxidation, anti-inflammation, and immune-regulation properties, and are promising in sport applications. In the present study, we designed a randomized, placebo-controlled, crossover trial to examine effects of 7-day supplementation of cystine/glutamine mixture (Cys2/Gln) on self-reporting fatigue index (ratings of perceived exertion, RPE), energy metabolism, and inflammation. We also employed a C2C12 myotube model to examine the capacity of cystine for fatty acid utilization. Cys2/Gln supplementation alleviated fatigue by decreasing RPE and enhanced fatty acid oxidation during a 60 min endurance exercise in human trials, while cystine increased fatty acid utilization in C2C12 myotubes by enhancing mitochondrial respiration. In summary, Cys2/Gln supplementation exerts positive effects on ameliorating exercise-induced fatigue, mechanisms of which can be attributed to enhancement of fatty acid utilization.\n OUTPUT:\n " }, { "from": "agent", "value": "Cystine/Glutamine Mixture Supplementation Attenuated Fatigue during Endurance Exercise in Healthy Young Men by Enhancing Fatty Acid Utilization." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Supracondylar fracture of the humerus is one of the most common fractures seen in children, and posteromedial displacement of the distal fragment in extension-type supracondylar humerus fractures can cause injury to the radial nerve. A 6-year old girl who presented with symptoms of radial nerve injury after a supracondylar fracture of the right humerus with complete posteromedial displacement of the distal fragment (Gartland type III) underwent surgery where closed reduction and percutaneous pinning was performed. The patient was routinely followed up and at 6 months postoperatively no neurological improvement was seen. Exploratory surgery revealed complete discontinuation of the radial nerve at the fracture site and entrapment of the nerve stumps in healed bone callus. A gap of 2 cm was observed between nerve stumps, and sural nerve cable grafting was performed with good results. If neurological symptoms do not improve over time, appropriate differential diagnosis and, if necessary, exploratory surgery should be considered. Despite limited reports and their conflicting outcomes, sural nerve cable grafting could be a useful option to bridge the gap of discontinued nerve injury. Level of Evidence: Level IV, Case Report.\n OUTPUT:\n " }, { "from": "agent", "value": "Radial nerve entrapment after fracture of the supracondylar humerus: a rare case of a 6-year-old." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In this paper, we demonstrate an active metamaterial manifesting electromagnetically induced transparency (EIT) effect in the microwave regime. The metamaterial unit cell consists of a double-cross structure, between which a varactor diode is integrated. The capacitance of the diode is controlled by a reversed electrical bias voltage supplied through two connected strip lines. The diode behaves as a radiative resonant mode and the strip lines as a non-radiative resonant mode. The two modes destructively interference with each other through conductive coupling, which leads to a transmission peak in EIT effect. Through electrical control of the diode capacitance, the transmission peak frequency is shifted from 7.4 GHz to 8.7 GHz, and the peak-to-dip ratio is tuned from 1.02 to 1.66, demonstrating a significant tunability.\n OUTPUT:\n " }, { "from": "agent", "value": "An Active Electromagnetically Induced Transparency (EIT) Metamaterial Based on Conductive Coupling." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Muscle quality defined as the ratio of muscle strength to muscle mass disregards underlying factors which influence muscle strength. The aim of this review was to investigate the relationship of phase angle (PhA), echo intensity (EI), muscular adipose tissue (MAT), muscle fiber type, fascicle pennation angle (θf), fascicle length (lf), muscle oxidative capacity, insulin sensitivity (IS), neuromuscular activation, and motor unit to muscle strength. PubMed search was performed in 2021. The inclusion criteria were: (i) original research, (ii) human participants, (iii) adults (≥18 years). Exclusion criteria were: (i) no full-text, (ii) non-English or -German language, (iii) pathologies. Forty-one studies were identified. Nine studies found a weak-moderate negative (range r: [-0.26]-[-0.656], \n OUTPUT:\n " }, { "from": "agent", "value": "Factors of Muscle Quality and Determinants of Muscle Strength: A Systematic Literature Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Meeting medical challenges posed by global burdens is proven to be of primary interest. One example is the COVID-19 epidemic that humankind is currently experiencing, since around December 2019. Innovation is key to respond rapidly and effectively to sanitary and health emergencies, when human lives are severely threatened. In this scenery, medical devices that can be rapidly launched in the market and manufactured at scale are crucial for saving lives. One example is a lifesaving respiratory device launched in about 10 days (Mercedes F1 team's new device based on continuous positive airway pressure devices) and rapidly approved by international agencies responsible for assuring drug and medical devices safety, in response to the COVID-19 burden. Remarkably, it is the first time in history that mankind observes disease spread reaching such high proportions, globally, in such short time scale. However, while this epidemic had, in March 2020, reached the critical figures of about 38,000 deaths and c. 738,000 infected, organ donation and transplantation patients are suffering for years, accounting for an increasing number of affected, annually. These patients are invisible for the general public. Therefore, this chapter approaches the organ donation and transplantation burden, proposing effective solutions to leverage the suffering, improving life quality of patients enduring several underlying issues, from hemodialysis complications and critical organ failure to lacking compatible donors. This, on the basis of technology repurposing, to speed up approval processes followed by international agencies responsible for assuring drug and medical devices safety, while adding innovative methods to existing technology and reducing invasiveness.\n OUTPUT:\n " }, { "from": "agent", "value": "Novel Nanotechnology-Driven Prototypes for AI-Enriched Implanted Prosthetics Following Organ Failure." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Nitrous oxide was introduced in The Netherlands as an easily accessible and effective agent for procedural sedation and analgesia (PSA) in children at the Emergency Department. It was expected that its adoption would increase due to the rapid onset of action, limited side effects and the non-invasive character. In this article, we discuss the efficacy and use of nitrous oxide in The Netherlands. Nitrous oxide is a safe and effective agent for children undergoing low-complex procedures. However, the analgesic effect is limited for complex procedures such as fracture reposition, necessitating the use of additional agents such as opioids. Against our expectations, most Dutch Emergency Departments do not use nitrous oxide. Reasons for this are the limited analgesic effects for most procedures, the availability of good alternatives and cost and sustainability considerations.\n OUTPUT:\n " }, { "from": "agent", "value": "[Nitrous oxide is not widely used for children in the emergency departments in The Netherlands]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective and cognitive processes, have not been completely mapped. We aimed to investigate regional cerebral blood flow (rCBF) changes over the DLPFC and the subgenual anterior cingulate cortex (sgACC) of different NIBS protocols using Single-Photon Emission Computed Tomography (SPECT). A factorial, within-subjects, double-blinded study was performed. Twenty-three healthy subjects randomly underwent four sessions of NIBS applied once a week: transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), combined tDCS + iTBS and placebo. The radiotracer 99m-Technetium-ethylene-cysteine-dimer was injected intravenously during the NIBS session, and SPECT neuroimages were acquired after the session. Results revealed that the combination of tDCS + iTBS increased right sgACC rCBF. Cathodal and anodal tDCS increased and decreased DLPFC rCBF, respectively, while iTBS showed no significant changes compared to the placebo. Our findings suggest that the combined protocol might optimize the activity in the right sgACC and encourage future trials with neuropsychiatric populations. Moreover, mechanistic studies to investigate the effects of tDCS and iTBS over the DLPFC are required.\n OUTPUT:\n " }, { "from": "agent", "value": "Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Females have higher age-adjusted incidence of Alzheimer's disease than males but the reasons for this remain unclear. One proposed contributing factor is that, historically, women had less access to education and therefore may accumulate less cognitive reserve. However, educational attainment is confounded by IQ, which in itself is a component of cognitive reserve and does not differ between sexes. Steeper age-related cognitive declines are associated with increased risk of dementia. We therefore evaluated the moderating effects of two proxies for cognitive reserve, education and IQ, on the steepness of age-related declining cognitive trajectories in unimpaired older males and females.\n OUTPUT:\n " }, { "from": "agent", "value": "Sex-Specific Protective Effects of Cognitive Reserve on Age-Related Cognitive Decline: A 5-Year Prospective Cohort Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Counseling of Implantable Cardioverter-defibrillator (ICD) patients with regard to individual risks and benefits is challenging. An evidence-based decision aid tailored to the needs of Dutch ICD patients is not yet available. The objective of this pilot project was to structurally evaluate the current clinical practice in The Netherlands and the ICD patient experience, in order to develop an online decision aid to facilitate shared decision making in ICD procedures.\n OUTPUT:\n " }, { "from": "agent", "value": "The development of a decision aid for shared decision making in the Dutch implantable cardioverter defibrillator patient population: A novel approach to patient education." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Intelligence is often discussed in terms of neural networks in the cerebral cortex, whose evolution has presumably been influenced by Darwinian selection. Here we present molecular evidence that one of the many kinesin motors, KIF14, has evolved to exhibit a special feature in its amino acid sequence that could improve neural networks. The improvement is quantified by comparison of NIF14 sequences for 12 species. The special feature is level sets of synchronized hydrophobic extrema in water wave profiles based on several hydropathic scales. The most effective scale is a new one based on fractals indicative of approach of globular curvatures to self-organized criticality, which summarizes evolutionary trends based on intelligent design.\n OUTPUT:\n " }, { "from": "agent", "value": "Darwinian Evolution of Intelligence." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In the present study, an eco-friendly process was made for the rapid synthesis of silver nanoparticles using aqueous leaf extract of Hibiscus sabdariffa. The process was characterized by Fourier Transform Infrared (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-visible and X-ray diffraction (XRD). These green silver nanoparticles (NPs) were used for mitigating the adverse effects of salinity on seed germination and growth parameters in plants. Accordingly, two experiments were conducted. In the first experiment, seven concentrations of green silver NPs and nine levels of NaCl:CaCl were apptoed on seeds for germination, and their effects were evaluated. In the second experiment, three concentrations of green silver NPs and NaCl were hypothesized to affect plant growth parameters. Seed germination, plant height, leaf, and root fresh and dry weights, as well as relative water content (RWC), decreased significantly under salt stress. However, green silver NPs intervened by alleviating the adverse effects of stress. Accordingly, green silver NPs were beneficial due to (1) activation of the antioxidant system by enhancing antioxidant enzymes such as catalase (CAT), ascorbate peroxidase (APX), peroxidase (POD), and superoxide dismutase (SOD); (2) increase in the amounts of proline, soluble sugars and carbohydrates for osmoprotection; (3) improvements in flavonoid and anthocyanin contents. Real-time PCR showed that flavonoid and anthocyanin contents increased because of higher expressions in chalcone synthase (CHS), flavanone 3-hydroxylase (F3H), and anthocyanidin synthase (ANS) genes. In conclusion, green silver NPs offered an eco-friendly application for further research on agricultural development.\n OUTPUT:\n " }, { "from": "agent", "value": "Alleviating the adverse effects of salinity on Roselle plants by green synthesized nanoparticles." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Pecan (\n OUTPUT:\n " }, { "from": "agent", "value": "Oxidative Stress Amelioration of Novel Peptides Extracted from Enzymatic Hydrolysates of Chinese Pecan Cake." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Fluoride pollution is widely present in the living environment. As a critical period of brain development, the perinatal period is extremely vulnerable to fluoride. Studies have found that choline can protect the brain's memory and enhance the ability to focus. However, the effect of choline on perinatal fluoride-induced nerve damage remains unclear. Therefore, 32 Kunming newly conceived female mice and their offspring mice were randomly divided into control, NaF, LC + NaF, and HC + NaF groups, and the HE staining, Y-maze test, RT-PCR, western blotting, immunohistochemistry, etc. were used in this study. The results showed that fluoride decreased the brain organ coefficients and brain protein content (p < 0.05, p < 0.01), and caused histomorphological damage in the hippocampus and cortex, which suggested that fluoride affected the development of the brain and damaged the brain. Moreover, the results of the Y-maze test showed that fluoride increased the number of learning days, error reaction time, and total reaction time, and decreased the AchE activity in the brain (p < 0.05, p < 0.01), which indicated that fluoride reduced the learning and memory ability of the mice. Besides, the results showed that fluoride decreased the mRNA and protein expression levels of α4β2 nAChRs and α7 nAChRs in the hippocampus and cortex (p < 0.05, p < 0.01). However, perinatal choline supplementation reversed the aforementioned fluoride-induced changes. In short, these results demonstrated that choline alleviated perinatal fluoride-induced learning and memory impairment, which will provide a rationale for the mitigation and prevention of fluoride-induced brain damage.\n OUTPUT:\n " }, { "from": "agent", "value": "Choline alleviated perinatal fluoride exposure-induced learning and memory impairment through α4β2 nAChRs and α7 nAChRs in offspring mice." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The purpose of this study was to evaluate the rehabilitation effects of four common interventions (BA: body acupuncture, SA: scalp acupuncture, TA: tongue acupuncture, SLT: speech and language training) used singly or in combination with language function in patients with post-stroke aphasia (PSA).\n OUTPUT:\n " }, { "from": "agent", "value": "Effects of Acupuncture-Related Therapies in the Rehabilitation of Patients with Post-Stroke Aphasia-A Network Meta-Analysis of Randomized Controlled Trials." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Toxic metal pollution requires significant adjustments in plant metabolism. Here, we show that the plant microbiota plays an important role in this process. The endophytic Sporobolomyces ruberrimus isolated from a serpentine population of Arabidopsis arenosa protected plants against excess metals. Coculture with its native host and Arabidopsis thaliana inhibited Fe and Ni uptake. It had no effect on host Zn and Cd uptake. Fe uptake inhibition was confirmed in wheat and rape. Our investigations show that, for the metal inhibitory effect, the interference of microorganisms in plant ethylene homeostasis is necessary. Application of an ethylene synthesis inhibitor, as well as loss-of-function mutations in canonical ethylene signalling genes, prevented metal uptake inhibition by the fungus. Coculture with S. ruberrimus significantly changed the expression of Fe homeostasis genes: IRT1, OPT3, OPT6, bHLH38 and bHLH39 in wild-type (WT) A. thaliana. The expression pattern of these genes in WT plants and in the ethylene signalling defective mutants significantly differed and coincided with the plant accumulation phenotype. Most notably, down-regulation of the expression of IRT1 solely in WT was necessary for the inhibition of metal uptake in plants. This study shows that microorganisms optimize plant Fe and Ni uptake by fine-tuning plant metal homeostasis.\n OUTPUT:\n " }, { "from": "agent", "value": "Endophytic yeast protect plants against metal toxicity by inhibiting plant metal uptake through an ethylene-dependent mechanism." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: A significant proportion of global road crashes are attributed to unsafe driving behaviors. The current study aimed to explore potential differences in driving behaviors across experienced and novice drivers using two separate approaches; a questionnaire study and an instrumented vehicle study (IVS). The analysis of 260 questionnaires and 1,372 traffic interactions within the IVS revelated that driving experience affects driving performance for different driving tasks. Factor analysis of the questionnaire data revealed the impact of driving errors, lapses, violations, and aggressive violations on the behavior of novice and experienced drivers. Behavioral models of novice and experienced drivers encountering other road users were determined using binary logistic regression. The results showed that novice drivers were more likely to engage in driving violations while experienced drivers were more likely to engage in aggressive violations. Unauthorized speeding, zigzag movements, using a mobile phone while driving, and unauthorized overtaking on roads were the most frequent driving violations by novice drivers. The most frequent aggressive violations by experienced drivers were tempting other drivers to create a race and chasing other drivers. These findings may be used as a framework to facilitate safer driving behaviors by reducing errors, lapses, violations and aggressive violations, and facilitating safety-promoting attitudes.\n OUTPUT:\n " }, { "from": "agent", "value": "An exploration of the role of driving experience on self-reported and real-world aberrant driving behaviors." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Pregnancy induces reprogramming of maternal physiology to support fetal development and growth. Maternal hepatocytes undergo hypertrophy and hyperplasia to drive maternal liver growth and alter their gene expression profiles simultaneously. This study aimed to further understand maternal hepatocyte adaptation to pregnancy.\n OUTPUT:\n " }, { "from": "agent", "value": "Maternal Hepatocytes Heterogeneously and Dynamically Exhibit Developmental Phenotypes Partially via YAP1 during Pregnancy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Community attitudes towards large carnivores are of central importance to their conservation in human-dominated landscapes. In this study, we evaluate community attitudes and perceptions towards the Amur tiger (Panthera tigris altaica), Amur leopard (Panthera pardus orientalis) and bears (Ursus thibetanus and Ursus arctos), as well as their prey species, namely sika deer (Cervus nippon), roe deer and wild boar (Sus scrofa), in Yanbian Korean Autonomous Prefecture, Jilin province, northeast China. We surveyed 139 households and found that community members' perceptions of large carnivores and their prey species were influenced by their predominant economic activities; their prior interactions with wildlife; their household income level; and whether they were either long-term residents of Yanbian or had migrated to the region from elsewhere in China. We recorded fairly neutral attitudes towards large carnivores among the communities we surveyed, but strongly negative attitudes were shown towards wild boar, particularly where respondents had lost agricultural products to crop raiding by wild boar. We recommend conservation stakeholders in northeast China utilise this finding to encourage support for large carnivore recovery and conservation by targeting messaging around the importance of the tiger as a key predator of wild boar in the ecosystem. Furthermore, our findings suggest that government provided compensation paid for cattle lost to large carnivore predation (notably, by tigers) may be helping to reduce animosity from cattle owners towards large carnivores. However, we also highlight that compensation for loss of livestock is therefore performing a useful role in mitigating human-wildlife conflict, that there are potentially unintended consequences of the current compensation program, for example it fails to dissuade livestock grazing in protected areas.\n OUTPUT:\n " }, { "from": "agent", "value": "Community attitudes towards Amur tigers (Panthera tigris altaica) and their prey species in Yanbian, Jilin province, a region of northeast China where tigers are returning." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Molecular changes in the brain of individuals afflicted with Alzheimer's disease (AD) are an intense area of study. Little is known about the role of protein abundance and posttranslational modifications in AD progression and treatment, in particular large-scale intact N-linked glycoproteomics analysis. To elucidate the N-glycoproteome landscape, we developed an approach based on multi-lectin affinity enrichment, hydrophilic interaction chromatography, and LC-MS-based glycoproteomics. We analyzed brain tissue from 10 persons with no cognitive impairment or AD, 10 with asymptomatic AD, and 10 with symptomatic AD, detecting over 300 glycoproteins and 1900 glycoforms across the samples. The majority of glycoproteins have N-glycans that are high-mannosidic or complex chains that are fucosylated and bisected. The Man5 N-glycan was found to occur most frequently at >20% of the total glycoforms. Unlike the glycoproteomes of other tissues, sialylation is a minor feature of the brain N-glycoproteome, occurring at <9% among the glycoforms. We observed AD-associated differences in the number of antennae, frequency of fucosylation, bisection, and other monosaccharides at individual glycosylation sites among samples from our three groups. Further analysis revealed glycosylation differences in subcellular compartments across disease stage, including glycoproteins in the lysosome frequently modified with paucimannosidic glycans. These results illustrate the N-glycoproteomics landscape across the spectrum of AD clinical and pathologic severity and will facilitate a deeper understanding of progression and treatment development.\n OUTPUT:\n " }, { "from": "agent", "value": "Glycoproteomics Landscape of Asymptomatic and Symptomatic Human Alzheimer's Disease Brain." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In species with separate sexes, females and males often differ in their morphology, physiology and behaviour. Such sex-specific traits are functionally linked to variation in reproductive competition, mate choice and parental care, which have all been linked to sex roles. At the 150th anniversary of Darwin's theory on sexual selection, the question of why patterns of sex roles vary within and across species remains a key topic in behavioural and evolutionary ecology. New theoretical, experimental and comparative evidence suggests that variation in the adult sex ratio (ASR) is a key driver of variation in sex roles. Here, we first define and discuss the historical emergence of the sex role concept, including recent criticisms and rebuttals. Second, we review the various sex ratios with a focus on ASR, and explore its theoretical links to sex roles. Third, we explore the causes, and especially the consequences, of biased ASRs, focusing on the results of correlational and experimental studies of the effect of ASR variation on mate choice, sexual conflict, parental care and mating systems, social behaviour, hormone physiology and fitness. We present evidence that animals in diverse societies are sensitive to variation in local ASR, even on short timescales, and propose explanations for conflicting results. We conclude with an overview of open questions in this field integrating demography, life history and behaviour.\n OUTPUT:\n " }, { "from": "agent", "value": "Sex roles and sex ratios in animals." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Regulating the activity of specific neurons is essentially important in neurocircuit dissection and neuropathy therapy. As a recently developed strategy, nanomaterial-enabled non-genetic neuromodulations that realize remote physical stimuli have made vast progress and shown great clinical potential. However, minimal invasiveness and high spatiotemporal resolution are still challenging for non-genetic neuromodulation. Herein, we report a second near-infrared (NIR-II) light-induced transcranial non-genetic neurostimulation via bioinspired nano-vesicles. The rationally designed vesicles are obtained from vesicle membrane-confined enzymatic reactions. This study demonstrates that the vesicle-enabled NIR-II photothermal stimuli can elicit neuronal signaling dynamics with precise spatiotemporal control and thus evoke defined neural circuits in non-transgenic mice. Moreover, the vesicle-mediated NIR-II optical stimulation can regulate mouse motor behaviors with minimal invasiveness by eliminating light-emitting implants. Furthermore, the biological modulation is integrated with photoacoustic brain imaging, realizing navigational and efficient neuromodulation. Such transcranial and precise NIR-II optical neuromodulation mediated by bioinspired vesicles shows the potential for the optical-theranostics of neurological diseases in non-transgenic organisms. This article is protected by copyright. All rights reserved.\n OUTPUT:\n " }, { "from": "agent", "value": "Transcranial Non-genetic Neuromodulation Via Bioinspired Vesicle-Enabled Precise NIR-II Optical-stimulation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In the current work, we designed and synthesized three families of non-fused and fused compounds based on cyanopyridone: derivatives of 6-amino-1,2-dihydropyridine-3,5-dicarbonitrile (\n OUTPUT:\n " }, { "from": "agent", "value": "Identification of Novel Cyanopyridones and Pyrido[2,3-" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Antivenom is an essential treatment for snake envenomation; however, early adverse reactions (EARs) are major limitations to its use. We performed a retrospective cross-sectional study using Ramathibodi Poison Center data (January 2016 to December 2017) to clarify the incidence and severity of EARs following different F(ab')₂ antivenoms. Among 1006 envenomed patients, 684 (68%) received antivenom therapy with a total of 1157 doses, mostly green pit viper antivenom. The overall EAR incidence and rate were 22. 5% (154/684) and 15% (173/1157), respectively. The EAR rate following each type of antivenom was &amp;gt;10%, except for Russell's viper antivenom (2.9%); the severe reaction rate was 2.6% (30/1157). Malayan pit viper bites caused a high incidence of EARs (37.8%) and the highest EAR rate (22.3%). Fifty-two cases developed anaphylaxis. All EARs occurred within 2 h after treatment initiation. No deaths were attributed to EARs. The duration of administration was significantly different between doses of antivenom that induced EARs and those that did not. In conclusion, all types and every dose of antivenom should be infused for 30-60 min. Preparation of resuscitation equipment and continuous clinical observation are crucial for at least 2 h after administration, and prompt treatment should be provided when EARs occur.\n OUTPUT:\n " }, { "from": "agent", "value": "Early Adverse Reactions to Snake Antivenom: Poison Center Data Analysis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Introduction COVID-19 is an infectious illness that first appeared in Wuhan, China in December 2019, and subsequently spread over the entire world. Those who were affected suffered from fever, cough, weakness, and breathlessness, along with the probability of developing pneumonia which sometimes leads to respiratory failure. The older population with co-morbidities was at higher risk. Methods In this experimental study, 59 subjects with COVID-19 were included according to pre-decided inclusion and exclusion criteria. Pre-vitals before the treatment were noted such as heart rate, respiratory rate, and oxygen saturation (SPO\n OUTPUT:\n " }, { "from": "agent", "value": "Immediate Effectiveness of Chest Proprioceptive Neuromuscular Facilitation (PNF) Technique on Hemodynamic Status in COVID-19 Patients: An Original Research." } ]