Datasets:

hippocrates

/

PubMed_Summ_train

like 0

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: <b>Aims:</b> To describe the diversity of pharmacogenomic variants affecting warfarin metabolism in Sri Lankans. <b>Materials &amp; methods:</b> Genotype data were filtered out from an anonymized database of 400 Sri Lankans, and minor allele frequencies (MAF) were calculated. Variants of <i>CYP2C9</i>, <i>VKORC1</i> and <i>CYP4F2</i> genes were studied. <b>Results:</b> Overall, <i>CYP2C9*2</i> and <i>CYP2C9*3</i> alleles had MAFs of 2.25% (95% CI: 0.80-3.70) and 10.38% (95% CI: 7.50-13.50), respectively. <i>CYP2C9*11</i> and <i>CYP2C9*14</i> alleles had MAFs of 0.13% (95% CI: 0-0.74) and 2.50% (95% CI: 0.97-4.03), respectively. MAFs of <i>VKORC1</i> variants rs7294, rs9934438, rs8050894 and rs2884737 were 47.25% (95% CI: 42.36-52.14), 10.13% (95% CI: 7.28-13.22), 9.88% (95% CI: 7.06-12.94) and 4.88% (95% CI: 2.86-7.14), respectively. MAF of <i>CYP4F2</i> variant rs2108622 was 45.63% (95% CI: 40.87-50.63). <b>Conclusion:</b> Compared with other populations, the frequencies of some studied variants were significantly different in Sri Lankans, and these are likely to account for variability in warfarin dosage requirements.\n OUTPUT:\n " }, { "from": "agent", "value": "Diversity of pharmacogenomic variants affecting warfarin metabolism in Sri Lankans." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Hyperforin is a representative polycyclic polyprenylated acylphloroglucinols (PPAPs) that exerts a variety of pharmacological activities. The complete biosynthesis pathway of hyperforin has not been elucidated due to its complex structure and unclear genetic background of its source plants. This mini-review focuses on the bioactivity and biosynthesis of hyperforin. These analyses can provide useful insights into the biosynthesis investigations of hyperforin and other PPAPs with complex structures.\n OUTPUT:\n " }, { "from": "agent", "value": "Targeting the biological activity and biosynthesis of hyperforin: a mini-review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The \n OUTPUT:\n " }, { "from": "agent", "value": "Draft Genome of " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: There is uncertainty whether multivessel (MV-PCI) or culprit-only percutaneous coronary intervention (CO-PCI) should be the treatment of choice in patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS) and multivessel disease (MVD).\n OUTPUT:\n " }, { "from": "agent", "value": "Multivessel versus Culprit-Only Percutaneous Coronary Intervention in Patients with Non-ST-Elevation Acute Coronary Syndrome." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In the coastal wetland, nitrogen is a limiting element for plant growth and reproduction. However, nitrogen inputs increase annually due to the rise in nitrogen emissions from human activity in coastal wetlands. Nitrogen additions may alter the coastal wetlands' soil properties, bacterial compositions, and plant growth. The majority of nitrogen addition studies, however, are conducted in grasslands and forests, and the relationship between soil properties, bacterial compositions, and plant growth driven by nitrogen addition is poorly understood in coastal marshes. We conducted an experiment involving nitrogen addition in the \n OUTPUT:\n " }, { "from": "agent", "value": "Nitrogen addition alters plant growth in China's Yellow River Delta coastal wetland through direct and indirect effects." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Objectives　Recent studies have shown a bidirectional association between diabetes and periodontal disease. However, the longitudinal association between periodontal pocket depth and new onset of diabetes remains controversial. Therefore, this study aimed to examine the association between periodontal pocket depth and new onset of diabetes using dental check-up data in a community-based population.Methods　The study comprised 5,163 participants aged≥20 years (mean age±standard deviation, 57.4±13.9 years; women, 66.3%) who underwent dental check-ups between April 2016 and March 2019 in a Tokyo ward. We classified the participants into three groups using community periodontal index codes from dental check-ups: healthy periodontal pocket group, periodontal pocket 4-5 mm group, and periodontal pocket ≥6 mm group. The participants were followed until the end of March 2020. Additionally, data on individuals who developed diabetes in the same ward were acquired from the National Health Insurance and Latter-Stage Older Persons Health Care System using ICD-10 codes. As the study outcome, we identified individuals who developed diabetes after the dental check-up date. Diabetes incidence rates were compared using the log-rank test and Cox regression analysis. Additionally, we performed a sensitivity analysis using a similar framework.Results　The log-rank test showed that the cumulative incidence of diabetes between the three groups was significantly different (P<0.01). A Cox regression analysis model adjusted for sex, age, smoking habits, number of teeth present, and oral hygiene status showed that the diabetes development hazard ratio (HR) for the periodontal pocket ≥6 mm group was 1.44 (95% confidence interval [CI]; 1.04-2.00) when compared with that of the healthy periodontal pocket group. In the sensitivity analysis of individuals aged ≥40 years, the HR for the periodontal pocket ≥6 mm group was 1.55 (95% CI; 1.11-2.16) when compared with that of the healthy periodontal pocket group. Similarly, among men aged ≥40 years, the HR for the periodontal pocket ≥6 mm group was 1.72 (95% CI; 1.04-2.85) when compared with that of the healthy periodontal pocket group. However, no significant association between new onset of diabetes and periodontal pocket depth was found for women aged ≥40 years (HR=1.39, 95% CI; 0.89-2.18).Conclusion　This The study suggests a longitudinal association between periodontal pocket depth and new onset of diabetes. The association was particularly pronounced in men aged ≥40 years. Therefore, men aged <40 years should maintain good oral health through appropriate dental health guidance to prevent the future development of diabetes.\n OUTPUT:\n " }, { "from": "agent", "value": "[Association between periodontal pocket depth determined during dental check-ups and new onset of diabetes in community residents: the LIFE study]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Adolescence is a vulnerable period for the development of eating disorders, but there are disparities in eating disorder risk among adolescents. One population that may be at increased risk but is vastly understudied, is adolescents residing in rural regions within the United States. Rural communities face many mental and physical health disparities; however, the literature on rural adolescent eating disorder risk is nearly nonexistent. In this paper we summarize the scant literature on disordered eating and eating disorder risk and prevalence among rural US adolescents. We also detail eating disorder risk factors that may have unique influence in this population, including socioeconomic status, food insecurity, healthcare access, body image, and weight stigma. Given the presence of numerous eating disorder risk factors, we speculate that rural adolescents may be a particularly vulnerable population for eating disorders and we propose critical next steps in research for understanding eating disorder risk among the understudied population of rural adolescents. PUBLIC SIGNIFICANCE: Rural adolescents may be at increased risk for eating disorders due to disproportionate burden of known risk factors, though this relationship remains understudied. We present a summary of the literature on prevalence and unique risk factors, proposing that this may be a high-risk population. We detail next steps for research to understand eating disorder risk in this population to inform future prevention, identification, and treatment efforts needed in this community.\n OUTPUT:\n " }, { "from": "agent", "value": "Eating disorder risk in rural US adolescents: What do we know and where do we go?" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Promoting a diverse workforce of healthcare professionals that delivers equitable patient care is an important goal in oncology, as in all of medicine. While most medical schools have a diversity office and associated initiatives, little is known about radiation oncology (RO) department-level efforts to promote diversity, equity, and inclusion (DEI). We describe the current state of DEI leadership and initiatives in RO departments in the US to guide future policies and programs.\n OUTPUT:\n " }, { "from": "agent", "value": "The Current State of Departmental Diversity, Equity, and Inclusion Efforts within US Academic Radiation Oncology Departments." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Assess family-level factors associated with childhood immunization schedule adherence.\n OUTPUT:\n " }, { "from": "agent", "value": "Vaccination Trends and Family-Level Characteristics Associated With Incomplete or Delayed Childhood Immunizations: The Healthy Start Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This paper studies the problem of practical synchronization for delayed neural networks via hybrid-driven impulsive control in which delayed impulses and external disturbance are taken into account. Firstly, a switching method which establishes the relationship between error signals and a threshold function is introduced, which determines whether time-driven control or event-driven control is activated. Secondly, the effects of delayed impulses and external disturbance on impulsive systems are considered, and the corresponding comparison lemma is proposed. Thirdly, whenever the norm of the initial value of the error system state is less than or greater than the initial value of the threshold function, under the proposed hybrid-driven impulsive control scheme, the practical synchronization of the delayed neural networks with delayed impulses and external disturbance can be achieved by synchronizing impulses. Moreover, the Zeno behavior can be excluded under the proposed hybrid-driven impulsive control. Finally, two numerical examples are presented to verify the effectiveness of the theoretical results.\n OUTPUT:\n " }, { "from": "agent", "value": "Practical synchronization of neural networks with delayed impulses and external disturbance via hybrid control." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Emergent phenomena at heterointerfaces are directly associated with the bonding geometry of adjacent layers. Effective control of accessible parameters, such as the bond length and bonding angles, offers an elegant method to tailor competing energies of the electronic and magnetic ground states. In this study, we construct unit-thick syntactic layers of cobaltites within a strongly tilted octahedral matrix via atomically precise synthesis. The octahedral tilt patterns of adjacent layers propagate into cobaltites, leading to a continuation of octahedral tilting while maintaining substantial misfit tensile strain. These effects induce severe rumpling within an atomic plane of neighboring layers, further triggering the electronic reconstruction between the splitting orbitals. First-principles calculations reveal that the cobalt ions transit to a higher spin state level upon octahedral tilting, resulting in robust ferromagnetism in ultrathin cobaltites. This work demonstrates a design methodology for fine-tuning the lattice and spin degrees of freedom in correlated quantum heterostructures by exploiting epitaxial geometric engineering.\n OUTPUT:\n " }, { "from": "agent", "value": "Atomically engineered cobaltite layers for robust ferromagnetism." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Hawthorn powder were mixed with corn starch and heated in water to make corn starch-hawthorn mixtures (CS-Haw) and then the physicochemical properties and hydrolysis characteristics of the mixtures were measured. Results showed that the addition of hawthorn powder decreased the viscosity of corn starch, and prolonged the pasting temperature, while the microstructure analysis indicated that hawthorn particles aggregated on the surfaces of starch granules, reducing the chance of starch contacting with water, then delayed the starch gelatinization. The presence of hawthorn powder also reduced the \n OUTPUT:\n " }, { "from": "agent", "value": "Effects of hawthorn addition on the physicochemical properties and hydrolysis of corn starch." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: A lateral flow immunoassay (LFA) biosensor that allows the sensitive and accurate identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other common respiratory viruses remains highly desired in the face of the coronavirus disease 2019 pandemic. Here, we propose a multiplex LFA method for the on-site, rapid, and highly sensitive screening of multiple respiratory viruses, using a multilayered film-like fluorescent tag as the performance enhancement and signal amplification tool. This film-like three-dimensional (3D) tag was prepared through the layer-by-layer assembly of highly photostable CdSe@ZnS-COOH quantum dots (QDs) onto the surfaces of monolayer graphene oxide nanosheets, which can provide larger reaction interfaces and specific active surface areas, higher QD loads, and better luminescence and dispersibility than traditional spherical fluorescent microspheres for LFA applications. The constructed fluorescent LFA biosensor can simultaneously and sensitively quantify SARS-CoV-2, influenza A virus, and human adenovirus with low detection limits (8 pg/mL, 488 copies/mL, and 471 copies/mL), short assay time (15 min), good reproducibility, and high accuracy. Moreover, our proposed assay has great potential for the early diagnosis of respiratory virus infections given its robustness when validated in real saliva samples.\n OUTPUT:\n " }, { "from": "agent", "value": "Introduction of graphene oxide-supported multilayer-quantum dots nanofilm into multiplex lateral flow immunoassay: A rapid and ultrasensitive point-of-care testing technique for multiple respiratory viruses." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Both the bulbs and flowers of \n OUTPUT:\n " }, { "from": "agent", "value": "UHPLC-Q-Exactive Orbitrap MS/MS-Based Untargeted Metabolomics and Molecular Networking Reveal the Differential Chemical Constituents of the Bulbs and Flowers of " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Non-alcoholic fatty liver disease (NAFLD) occurs in 25% of the global population and manifests as lipid deposition, hepatocyte injury, activation of Kupffer and stellate cells, and steatohepatitis. Predominantly expressed in hepatocytes, the augmenter of liver regeneration (ALR) is a key factor in liver regulation that can alleviate fatty liver disease and protect the liver from abnormal liver lipid metabolism. ALR has three isoforms (15-, 21-, and 23-kDa), amongst which 23-kDa ALR is the most extensively studied. The 23-kDa ALR isoform is a sulfhydryl oxidase that resides primarily in the mitochondrial intermembrane space (IMS), whereby it protects the liver against various types of injury. In this review, we describe the role of ALR in regulating hepatocytes in the context of NAFLD. We also discuss questions about ALR that remain to be explored in the future. In conclusion, ALR appears to be a promising therapeutic target for treating NAFLD.\n OUTPUT:\n " }, { "from": "agent", "value": "The protective roles of augmenter of liver regeneration in hepatocytes in the non-alcoholic fatty liver disease." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Chemical investigation of an EtOAc extract of the endophytic fungus \n OUTPUT:\n " }, { "from": "agent", "value": "Pseudocercones A-C, three new polyketide derivatives from the endophytic fungus " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Bermudagrass (Cynodon dactylon L.) is an important warm-season turfgrass species with well-developed stolons, which lay the foundation for the fast propagation of bermudagrass plants through asexual clonal growth. However, the growth and development of bermudagrass stolons are still poorly understood at the molecular level.\n OUTPUT:\n " }, { "from": "agent", "value": "Proteome-wide analyses reveal diverse functions of protein acetylation and succinylation modifications in fast growing stolons of bermudagrass (Cynodon dactylon L.)." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Currently, the effect of selenium and oxidized fish oil interactions on the intestinal lipid metabolism and antioxidant responses of fish remains unknown. Herein, yellow catfish \n OUTPUT:\n " }, { "from": "agent", "value": "Effects of Dietary Selenium and Oxidized Fish Oils on Intestinal Lipid Metabolism and Antioxidant Responses of Yellow Catfish " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The immune response induced by surface topography crucially determines the implant success. However, how the immune response is mediated by the size of surface topography remains unclear. Hence, various biocompatible Mg-Al layered double hydroxides sheet-array films with different sizes (nano, micro and nano/micro mixture) were constructed on the biomedical titanium, and their osteo-immunomodulation effects on the macrophages were explored. The nano-sheet array structures significantly promoted the polarization of M2 macrophages by activating the PI3K-AKT-mTOR signaling pathway with high gene expressions of integrin β2 and FAK. While the micro-sheet array structures enhanced osteogenic differentiation of mouse bone marrow mesenchymal stem cells (mBMSCs) \n OUTPUT:\n " }, { "from": "agent", "value": "Effect of micro/nano-sheet array structures on the osteo-immunomodulation of macrophages." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Dr. Purushottam Vishwanath Gharpure was an eminent Indian pathologist and an emeritus Professor of Pathology at the Grant Medical College, Bombay. He was a pioneer in carrying out the first field trial of polio vaccination which marked the beginning of the polio eradication program in India. Dr. Gharpure set an example by taking his laboratory work to the field and proving how the laboratory research can be used to better the society. The mesmerizing story of Dr. \"Gharpure's life\" is described in this paper.\n OUTPUT:\n " }, { "from": "agent", "value": "Dr. P. V. Gharpure - An eminent Indian pathologist and a pioneer in starting oral polio vaccination in India." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Acute respiratory infection by influenza virus is a persistent and pervasive public health problem. Antiviral innate immunity initiated by type I interferon (IFN) is the first responder to pathogen invasion and provides the first line of defense. We discovered that Axin1, a scaffold protein, was reduced during influenza virus infection. We also found that overexpression of Axin1 and the chemical stabilizer of Axin1, XAV939, reduced influenza virus replication in lung epithelial cells. This effect was also observed with respiratory syncytial virus and vesicular stomatitis virus. Axin1 boosted type I IFN response to influenza virus infection and activated JNK/c-Jun and Smad3 signaling. XAV939 protected mice from influenza virus infection. Thus, our studies provide new mechanistic insights into the regulation of the type I IFN response and present a new potential therapeutic of targeting Axin1 against influenza virus infection.\n OUTPUT:\n " }, { "from": "agent", "value": "Axin1: A novel scaffold protein joins the antiviral network of interferon." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Different movement speeds can contribute to different joint loading in sports. Joint contact force is the actual force acting on the articular surface, which could predict performance and injury, but is rarely reported for badminton overhead strokes. Through an approach using musculoskeletal modelling, six male elite badminton players performed forehand overhead strokes at different movement speeds (fast (100%) vs. moderate (90%)). The synchronized kinematics and ground reaction force (GRF) data were measured using a motion capturing system and a force platform. All kinematics and GRF information were input into the AnyBody musculoskeletal modelling to determine the three-dimensional hip, knee and ankle contact forces. Paired \n OUTPUT:\n " }, { "from": "agent", "value": "Biomechanical Analysis on Skilled Badminton Players during Take-Off Phase in Forehand Overhead Strokes: A Pilot Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Kidney transplantation is the definitive treatment for end stage renal disease (ESRD), offering improved quality of life and survival benefit over remaining on dialysis. There is, however, a prevailing significant mismatch between patients awaiting transplantation and available donor kidneys. Over time, initial stringent donor criteria have broadened and organs from extended criteria donors (ECDs) and older donors are now being accepted for transplantation. The spectrum of living donors has also undergone a change from close family members to an increasingly non-related, non-directed altruistic donors, newly classified as 'unspecified' donors. Unspecified elderly donors could be a potential untapped resource to expanding the kidney donor pool globally.\n OUTPUT:\n " }, { "from": "agent", "value": "The altruistic elderly, a valuable but unrecognised kidney donor group. A case report of an 85-year-old unspecified kidney donor." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To explore the clinical effect of the tuberculosis (TB) doctor-nurse integration management model METHODS: This study is a retrospective historical cohort study. The clinical data of 180 patients with TB in our hospital from 2019 to 2020 were analyzed retrospectively. In a control group, 90 cases were treated with the traditional medical care model. An observation group of 90 cases received clinical diagnoses, treatments, and nursing under a doctor-nurse integration management model. Comparative analyses between the two groups were conducted on various aspects, including the awareness level of TB prevention and control, medication compliance and patient satisfaction. Comparisons between the two groups were evaluated using independent-sample t-tests or Chi-squared tests RESULTS: Compared with the control group, the knowledge awareness levels of TB prevention and medication compliance in the observation group were significantly higher (p < .05). The appointment waiting times and hospitalization times in the observation group were significantly lower than in the control group (p < .05). The total average satisfaction score of the patients in the observation group was significantly higher than in the control group (p < .05). Compared with the control group, the patients in the observation group were significantly more satisfied with their nursing methods, operating techniques, psychological techniques, service attitudes, and ward management (p < .05). In addition, in the observation group, medical-nursing relationships and doctor-patient communication were better than in the control group; additionally, the satisfaction of doctors with nursing work was also higher than in the control group, which was a statistically significant difference (p < .05) CONCLUSION: The implementation of an integrated medical-nursing cooperation model for TB will help increase the awareness of health knowledge in patients with TB, improve patient medication compliance and enhance patient satisfaction.\n OUTPUT:\n " }, { "from": "agent", "value": "Construction and application of tuberculosis medical and nursing integration cooperation model." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Alzheimer's disease (AD) is a common neurodegenerative disorder causing dementia in the elderly population. Functional disconnection of brain is considered to be the main cause of AD. In this study, we applied a newly developed association (Asso) mapping approach to directly quantify the functional disconnections and to explore the diagnostic effects for AD with resting-state functional magnetic resonance imaging data from 36 AD patients and 42 age-, gender-, and education-matched healthy controls (HC). We found that AD patients showed decreased Asso in left dorsoanterior insula (INS) while increased functional connections of INS with right medial prefrontal cortex (MPFC) and left posterior cingulate cortex (PCC). The changed Asso and functional connections were closely associated with cognitive performances. In addition, the reduced Asso and increased functional connections could serve as effective neuromarkers to distinguish AD patients from HC. Our research provided new evidence for functional disconnections in AD and demonstrated that functional disconnections between cognition-memory networks may be potential early biomarkers for AD.\n OUTPUT:\n " }, { "from": "agent", "value": "Altered functional association and couplings: Effective diagnostic neuromarkers for Alzheimer's disease." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Host-virus protein interactions are critical for intracellular viral propagation. Understanding the interactions between cellular and viral proteins may help us develop new antiviral strategies. Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus that causes severe damage to the global swine industry. Here, we employed co-immunoprecipitation and liquid chromatography-mass spectrometry to characterize 426 unique PEDV nucleocapsid (N) protein-binding proteins in infected Vero cells. A protein-protein interaction network (PPI) was created, and gene ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) database analyses revealed that the PEDV N-bound proteins belong to different cellular pathways, such as nucleic acid binding, ribonucleoprotein complex binding, RNA methyltransferase, and polymerase activities. Interactions of the PEDV N protein with 11 putative proteins: tripartite motif containing 21, DEAD-box RNA helicase 24, G3BP stress granule assembly factor 1, heat shock protein family A member 8, heat shock protein 90 alpha family class B member 1, YTH domain containing 1, nucleolin, Y-box binding protein 1, vimentin, heterogeneous nuclear ribonucleoprotein A2/B1, and karyopherin subunit alpha 1, were further confirmed by in vitro co-immunoprecipitation assay. In summary, studying an interaction network can facilitate the identification of antiviral therapeutic strategies and novel targets for PEDV infection.\n OUTPUT:\n " }, { "from": "agent", "value": "The Network of Interactions between the Porcine Epidemic Diarrhea Virus Nucleocapsid and Host Cellular Proteins." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The plastic concentration in terrestrial systems is orders of magnitude higher than that found in marine ecosystems, which has raised global concerns about their potential risk to agricultural sustainability. Previous research on the transport of nanoplastics in soil relied heavily on the qualitative prediction of the mean-field extended Derjaguin-Landau-Verwey-Overbeek theory (XDLVO), but direct and quantitative measurements of the interfacial forces between single nanoplastics and porous media are lacking. In this study, we conducted multiscale investigations ranging from column transport experiments to single particle measurements. The maximum effluent concentration (C/C0) of amino-modified nanoplastics (PS-NH\n OUTPUT:\n " }, { "from": "agent", "value": "Using colloidal AFM probe technique and XDLVO theory to predict the transport of nanoplastics in porous media." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To clarify the views of the general population of two countries (US and Japan), concerning handling of their medical records electronically, disclosure of the name of disease, secondary usage of information, compiling their records into a lifelong medical record, access to their medical records on the internet, questionnaire filling for delicate history, comprehensive consent for laboratory results, chart and genome profile, and AI use in diagnosis and explanation.\n OUTPUT:\n " }, { "from": "agent", "value": "Surveys Aimed at General Citizens of the US and Japan About Their Attitudes Toward Electronic Medical Data Handling - 10 Years Change, Before and After Covid-19." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This was a retrospective cohort study aimed at identifying parameters measured at diagnosis of pediatric IBD to predict subsequent biologic therapy, as an equivalent to an unfavorable clinical course. Identification of predictors of poor outcomes is an important issue in current ECCO guidelines on pIBD. The study population consisted of 119 children with Crohn's disease and 112 with ulcerative colitis, diagnosed and monitored for at least 1 year from 2009-2019. The population was divided into the study groups separately: 39 children with CD and 14 with UC who received biologics before the age of 18 y compared to 80 with CD and 98 with UC who did not. The combined analysis of 53 biologic therapy recipients vs. 178 non-recipients with IBD was also conducted. Logistic regression tests (OR, RR) and sensitivity, specificity, PPV, and NPV were used. Factors significantly correlated with subsequent biologic therapy were perianal disease, complicated disease behavior, high PCDAI (CD), fatigue, hypoalbuminemia, high PUCAI (UC) and fever, fatigue, hypoalbuminemia, hypoproteinemia, and elevated CRP (IBD). Marginally significant factors were ileocecal disease, elevated serum IgA, anemia, and L4a-L4b coexistence. Apart from parameters already accepted as POPO (B2/3, perianal disease), interesting observations are the significance of IgA, L4a-L4b in CD, and hypoalbuminemia in UC.\n OUTPUT:\n " }, { "from": "agent", "value": "Prognostic Factors of Biologic Therapy in Pediatric IBD." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Flux balance analysis (FBA) is a crucial method to analyze large-scale constraint-based metabolic networks and computing design strategies for strain production in metabolic engineering. However, as it is often non-straightforward to obtain such design strategies to produce valuable metabolites, many tools have been proposed based on FBA. Among them, GridProd, which divides the solution space into small squares by focusing on the cell growth rate and the target metabolite production rate to efficiently find the reaction deletion strategies, was extended to CubeProd, which divides the solution space into small cubes. However, as GridProd and CubeProd naively divide the solution space into equal sizes, even places where solutions are unlikely to exist are examined. To address this issue, we introduce dynamic solution space division methods based on CubeProd for faster computing by avoiding searching in places where the solutions do not exist. We applied the proposed method DynCubeProd to iJO1366, which is a genome-scale constraint-based model of \n OUTPUT:\n " }, { "from": "agent", "value": "Dynamic Solution Space Division-Based Methods for Calculating Reaction Deletion Strategies for Constraint-Based Metabolic Networks for Substance Production: DynCubeProd." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Chemerin is a multifunctional adipokine that regulates adipogenesis, insulin signaling and blood pressure and has thus a central function in metabolism. Mounting evidence confirmed a function of chemerin in various cancers. In this study, we investigated the role of chemerin in rhabdomyosarcoma (RMS), an aggressive soft tissue cancer that affects mainly children and young adults. We found chemerin expression in 93.8% (90 of 96) of RMS cases, with a range of 86.7-96.7% for the four RMS subgroups. While chemerin is uniformly expressed in normal skeletal muscle, its expression in RMS is patchy with interspersed areas that are devoid of chemerin. This variable chemerin expression is reflected by RMS cell lines as two of them (Rh41 and Rd18) were found to secrete chemerin while the two other ones (JR1 and RD) were negative. Deletion of chemerin in Rh41 and Rd18 cells did not alter their growth rate or morphology. We investigated the potential influence of chemerin on immune surveillance by coculturing parental and chemerin-deficient RMS cells with resting- or lipopolysaccharide (LPS)-activated human peripheral monocytes. The absence of chemerin in the RMS cells led to increased expression levels of the coinhibitory molecules PD-L1 and PD-L2 while levels of the costimulatory molecule CD86 were not changed. Further, the absence of chemerin enhanced the secretion of cytokines (IL-1β, IL-6, IL-10 and TNF) that have been shown to support RMS pathogenesis. These data indicate that the loss of chemerin expression by RMS cells repolarizes monocytes in the tumor microenvironment to supporting tumor progression.\n OUTPUT:\n " }, { "from": "agent", "value": "Loss of Chemerin in Rhabdomyosarcoma Cells Polarizes Adjacent Monocytes to an Immunosuppressive Phenotype." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Pulsed field ablation (PFA) is a promising new ablation modality for the treatment of atrial fibrillation (AF); however, the effect of fiber orientation on the ablation characteristics of PFA in AF treatment is still unclear, which is likely an essential factor in influencing the ablation characteristics. This study constructed an anatomy-based left atrium (LA) model incorporating fiber orientation and selected various electrical conductivity and ablation targets to investigate the effect of anisotropic electrical conductivity (AC), compared with isotropic electrical conductivity (IC), on the ablation characteristics of PFA in AF treatment. The results show that the percentage differences in the size of the surface ablation area between AC and IC are greater than 73.71%; the maximum difference in the size of the ablation isosurface between AC and IC at different locations in the atrial wall is 3.65 mm (\n OUTPUT:\n " }, { "from": "agent", "value": "Effect of Anisotropic Electrical Conductivity Induced by Fiber Orientation on Ablation Characteristics of Pulsed Field Ablation in Atrial Fibrillation Treatment: A Computational Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Facial and cochlear nerve preservation in large vestibular schwannomas is a major challenge. Bimanual pincers or plate-knife dissection techniques have been described as crucial for nerve preservation. The authors demonstrate a recently applied diamond knife dissection technique to peel the nerves from the tumor capsule. This technique minimizes the nerve trauma significantly, and complete resection of a large vestibular schwannoma without any facial nerve palsy and hearing preservation is possible. The authors illustrate this technique during surgery of a 2.6-cm vestibular schwannoma in a 27-year-old male patient resulting in normal facial function and preserved hearing postoperatively. The video can be found here: https://stream.cadmore.media/r10.3171/2021.7.FOCVID21104.\n OUTPUT:\n " }, { "from": "agent", "value": "Diamond knife dissection technique for nerve preservation during resection of large vestibular schwannomas." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The abundance and biological role of potassium suggest that its unstable nuclide was present in all stages of terrestrial biogenesis. With its enhanced isotopic ratio in the Archean eon, 40K may have contributed to the special, perhaps unique, biogenetic conditions that were present in the primitive Earth. Compared to the U and Th radionuclides, 40K has a less disruptive radiochemical impact, which may drive a moderate, but persistent evolution of the structural and functional properties of proto-biological molecules. In the main β-decay route of 40K, the radiation dose generated by an Archean solution with potassium ions can be larger than the present background radiation on Earth by one to two orders of magnitude. Estimates of the rates of organic molecules indirectly affected by β decays are provided for two schematic models of the propagation of secondary events in the solvent of prebiotic solutions. The left-handed β- particles emitted by 40K are the best candidates to trigger an enantiomeric excess of L-type amino acids via weak nuclear forces in the primitive Earth. The concentration-dependent radiation dose of 40K fits well in dry-wet scenarios of life's origins and should be considered in realistic simulations of prebiotic chemical pathways.\n OUTPUT:\n " }, { "from": "agent", "value": "On the Role of " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Recent research has contested the previously accepted paradigm that volatile anaesthetics improve outcomes in cardiac surgery patients when compared to intravenous anaesthesia. In this review we summarise the mechanisms of myocardial ischaemia/reperfusion injury and cardioprotection in cardiac surgery. In addition, we make a comprehensive analysis of evidence comparing outcomes in patients undergoing cardiac surgery under volatile or intravenous anaesthesia, in terms of mortality and morbidity (cardiac, neurological, renal, pulmonary).\n OUTPUT:\n " }, { "from": "agent", "value": "Volatile Anaesthesia versus Total Intravenous Anaesthesia for Cardiac Surgery-A Narrative Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To investigate cardiac pathology in critically ill patients with coronavirus disease 2019 (COVID-19) and identify associations between pathological changes and clinical characteristics.\n OUTPUT:\n " }, { "from": "agent", "value": "Neutrophil infiltration and myocarditis in patients with severe COVID-19: A post-mortem study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Dementia is a syndrome that impairs learning and memory. To date, there is no effective therapy for dementia. Current prescription drugs, such as cholinesterase inhibitors, fail to improve the condition of dementia and are often accompanied by severe adverse effects. In recent years, the number of studies into the use of traditional Chinese medicine (TCM) for dementia treatment has increased, revealing a formula that could significantly improve memory and cognitive dysfunctions in animal models. TCM showed fewer adverse effects, lower costs, and improved suitability for long-term use compared with currently prescribed drugs. Due to the complexity of ingredients and variations in bioactivity of herbal medicines, the multi-target nature of the traditional Chinese formula affected the outcome of dementia therapy. Innovations in TCM will create a platform for the development of new drugs for the prevention and treatment of dementia, further strengthening and enhancing the current influence of TCM.\n OUTPUT:\n " }, { "from": "agent", "value": "Traditional Chinese medicine promotes the control and treatment of dementia." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Many compounds containing the β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold, including cinnamamide derivatives, have been shown to inhibit tyrosinase potently in vitro and in vivo. Structural changes to cinnamamide derivatives were produced by adding a dithionate functional group to provide eight (\n OUTPUT:\n " }, { "from": "agent", "value": "Design and Synthesis of (" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Focal therapy has emerged as an interesting option for localized low- to intermediate-risk prostate cancer (PCa). Targeted microwave ablation (TMA) is a novel FT modality involving targeted delivery of microwave energy under multiparametric magnetic resonance imaging (MRI)/ultrasound guidance.\n OUTPUT:\n " }, { "from": "agent", "value": "Safety and Feasibility of Transperineal Targeted Microwave Ablation for Low- to Intermediate-risk Prostate Cancer." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The aim of this study is to assess the bone mineral density (BMD) and \n OUTPUT:\n " }, { "from": "agent", "value": "Bone Mineral Density Reference Values in 18- to 95-Year-Old Population in Lombardy Region, Italy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: A rapid and simple HPLC-DAD analytical method was developed and optimized for the determination of anthocynanins in three red Greek winegrape varieties (Kotsifali, Limnio, and Vradiano). The critical parameters, such as the acidifying solvent and the extraction temperature, which affect the extraction of anthocyanins from the grapes, were studied to find the optimum values. The developed methodology was validated in terms of selectivity, linearity, accuracy, and precision and presented satisfactory results. The limits of quantification (LOQs) ranged between 0.20 mg/kg to 0.60 mg/kg, and the limits of detection (LODs) ranged between 0.06 mg/kg and 0.12 mg/kg. The RSD% of the within-day and between-day assays were lower than 6.2% and 8.5%, respectively, showing adequate precision. The accuracy ranged between 91.6 and 119% for within-day assay and between 89.9 and 123% for between-day assay. Sixteen samples from the main regions of each variety as well as from the official ampelographic collections of Greece were collected during the 2020 growing season and were further analyzed by HPLC-DAD. Notable differences in the anthocyanin content were detected among the cultivars using hierarchical cluster analysis (HCA).\n OUTPUT:\n " }, { "from": "agent", "value": "An Optimized HPLC-DAD Methodology for the Determination of Anthocyanins in Grape Skins of Red Greek Winegrape Cultivars (" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The mass separation of chemical element mixtures is a relevant task for numerous applications in the nuclear power industry. One of the promising approaches to solve this problem is plasma mass separation. In a recent study, the efficiency of plasma mass separation in a configuration with a potential well and a homogeneous magnetic field was experimentally demonstrated. This article examines the possibility of increasing the distance between the deposition regions of charged particles with different masses by varying the profile of the electric field potential. Such correlation can be considered as the control in a system of active particles. A cylindrical coordinate system is used. The electric field is axially symmetrical, and the magnetic field is directed along the axis of the symmetry. The corresponding mathematical problem was solved in a general way. The criteria for increasing the distance between the deposition areas of the \"light\" and \"heavy\" components of the mixture have been formulated. A high sensitivity of particle trajectories to the electric field potential in the region of the pericentres of the trajectories of charged particles was detected. Recommendations for the practical implementation of the optimal spatial separation of ion fluxes are proposed.\n OUTPUT:\n " }, { "from": "agent", "value": "The Optimal Axis-Symmetrical Plasma Potential Distribution for Plasma Mass Separation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Lung cancer is one of the most common malignant tumors in the world, and its incidence and mortality rate rank among the top malignant tumors worldwide, which has become an important killer threatening human survival rate and well-being. Modern medical treatment for lung cancer is mainly based on surgery and radiotherapy, with gene, targeted drugs and immunotherapy as auxiliary treatments, which are effective, but there are problems such as postoperative recurrence, resistance to radiotherapy, toxic side effects and poor compliance. In recent years, with the continuous development of TCM, TCM is popular among physicians and patients for its high efficiency, low toxicity, low side effects and economic benefits, etc. As a classical TCM formula, Qianjin Weijin Decoction(QJWJ) has certain value in the treatment of lung cancer. This paper summarizes and analyzes the clinical research, molecular mechanism, pharmacological effects and chemical composition of QJWJ in the treatment of lung cancer, in order to provide more ideas and theoretical basis for the treatment of lung cancer with QJWJ.\n OUTPUT:\n " }, { "from": "agent", "value": "A Chinese classical prescription Qianjinweijing Decoction in treatment of lung cancer: An overview." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The Memory Complaints Inventory (MCI) is a stand-alone memory-based symptom validity test (SVT). The measure is promising and has been used with relative frequency, but requires additional research (Armistead-Jehle & Shura, 2022). The current study sought to expand the empirical base of the MCI by comparing it to the Cognitive Bias Scale, a new symptom validity measure assessing cognitive over reporting on the Personality Assessment Inventory (PAI).\n OUTPUT:\n " }, { "from": "agent", "value": "Comparison of the Memory Complaints Inventory and the PAI Cognitive Bias Scale in a Military Sample." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cast steel is commonly used to produce structural and safety parts. Foundry processes allow producing parts from scrap steel directly to the required dimensions without any forming operation. Cast components may, however, exhibit macro- and micro-shrinkage porosities. The combined effect of macro- and micro-shrinkages on the fatigue behavior of cast steel has been characterized in the literature. Macro-shrinkages may nowadays be eliminated by adequate positioning of risers. However, micro-shrinkages will always be present in cast steel components. Present work addresses the influence of micro-shrinkage porosity on a G20Mn5 cast steel. G20Mn5 (normalized) ingots have been cast under industrial conditions, but ensuring the absence of macro-porosities. Solidification leads to two very different microstructures prior to the normalization treatment: columnar dendrites beneath the surface (\n OUTPUT:\n " }, { "from": "agent", "value": "Low Cycle Fatigue of G20Mn5 Cast Steel Relation between Microstructure and Fatigue Life." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Micro/nano-contaminants have been the focal pollutants in environmental science, which includes several nanomaterials, nanocomposites, fibers, glass, plastics etc. Micro/nano size pollutants are more harmful than macro pollutants due to their size. Therefore, there is an urgent need for research on the possible fate of glass particles in the environment, especially in plant and soil systems. Here, the synthesized nano-glass (NG) from the waste windshield and analyzed its uptake and effect on the wheat (\n OUTPUT:\n " }, { "from": "agent", "value": "Impact of nano-glass (NG) particles on seed germination and it's accumulation in plant parts of wheat (" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Hypoxia is defined as a cellular stress condition caused by a decrease in oxygen below physiologically normal levels. Cells in the core of a rapidly growing solid tumor are faced with the challenge of inadequate supply of oxygen through the blood, owing to improper vasculature inside the tumor. This hypoxic microenvironment inside the tumor initiates a gene expression program that alters numerous signaling pathways, allowing the cancer cell to eventually evade adverse conditions and attain a more aggressive phenotype. A multitude of studies covering diverse aspects of gene regulation has tried to uncover the mechanisms involved in hypoxia-induced tumorigenesis. The role of epigenetics in executing widespread and dynamic changes in gene expression under hypoxia has been gaining an increasing amount of support in recent years. This chapter discusses, in detail, various epigenetic mechanisms driving the cellular response to hypoxia in cancer.\n OUTPUT:\n " }, { "from": "agent", "value": "Epigenetic Regulation During Hypoxia and Its Implications in Cancer." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The 1,4-α-glucan branching enzymes (GBEs, EC 2.4.1.18), is reported to catalyze the formation of α-1,6 branching points in carbohydrates, which has ability of changing the structure of starch by adjusting the points and frequency of branch points in starch. In practical uses, GBEs are expected to be used at relatively high temperature because of high temperature requirement of starch gelatinization process. However, the present GBE does not meet the requirements, which limits the application of GBEs in starch modification industry. In order to enhance the thermostability of GBE, we combined the values of B-factor and accessible surface area, as well as the opportunity of building potential salt bridges in this enzyme. As a result, amino acid sites 73 and 137 in GBE from Geobacillus thermoglucosidans STB02 were selected in our research. The results show that substitution of Lys with Glu at amino acid 137 site resulted in an approximately 36.6 % enhancement in half-time; replacement of Gln with Asp at this site resulted in a 26 % improvement in thermostability. In addition to thermostability, catalytic ability is another factor to be concerned in our study. We constructed combined mutants with high catalytic efficiency and high thermostability. Compared with wild type, the resulting mutants have advantages in maltodextrin modification, of which product exhibited stronger stability than unmodified maltodextrin. Our study provides a new approach to increase thermostability of present GBE and create mutants with high thermostability and catalytic ability.\n OUTPUT:\n " }, { "from": "agent", "value": "Thermostability and catalytic ability enhancements of 1,4-α-glucan branching enzyme by introducing salt bridges at flexible amino acid sites." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Force feedback is a critical element for performing and learning surgical suturing skill. Force feedback is impoverished or not present at all in non-open surgery (i.e., in simulation, laparoscopic, and robotic-assisted surgery), but it can be augmented using different modalities. This rapid, systematic review examines how the modality of delivering force feedback influences the performance and learning of surgical suturing skills.\n OUTPUT:\n " }, { "from": "agent", "value": "How does the modality of delivering force feedback influence the performance and learning of surgical suturing skills? We don't know, but we better find out! A review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The treatment of benign skull base tumors remains challenging. These tumors are often located in close relationship to critical structures. Therefore, radical resection of these tumors can be associated with high morbidity. Multimodal treatment concepts, including controlled partial tumor resection followed by radiosurgery, should be considered.\n OUTPUT:\n " }, { "from": "agent", "value": "Adaptive Hybrid Surgery Experiences in Benign Skull Base Tumors." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The early detection of inflammation and infection is important to prevent irreversible lung damage in cystic fibrosis. Novel and non-invasive monitoring tools would be of high benefit for the quality of life of patients. Our group previously detected over 100 exhaled mass-to-charge (\n OUTPUT:\n " }, { "from": "agent", "value": "Identification of Exhaled Metabolites in Children with Cystic Fibrosis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Myelodysplastic syndrome is one of the main hematological malignancies that threaten the health of the elderly. However, biomarkers which predict the progression and prognosis of MDS are still controversial and puzzling. FOXO1 gene plays an important role in a variety of intracellular functions, including tumor suppression and cellular immune regulation. However, there is no research report on the correlation between FOXO1 and the clinical features of MDS including immune environment. In this study, we observed that FOXO1 expression is associated with neutrophil count, blasts, chromosome and different MDS scoring systems. FOXO1 expression is closely related to MDS cell immune polarization, and the increase expression of FOXO1 is significantly related to the amplification of immune cell polarization ratio. In addition, FOXO1 expression is associated with progression-free survival and overall survival in MDS patients. Moreover, in a multivariate model FOXO1 low-expression was an independent predictor of poor survival in MDS. In summary, FOXO1 may play a candidate tumor suppressor in MDS, and FOXO1 is a useful independent prognostic predictor in MDS, and it may provide a candidate target therapy in future.\n OUTPUT:\n " }, { "from": "agent", "value": "Decreased FOXO1 Expression Is Correlated with Poor Prognosis in Myelodysplastic Syndromes." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Though critical to primary care, continuity of care has rarely been examined in China. This study aims to assess the relationship between continuity of care and healthcare costs among patients with chronic diseases within primary care settings in China.\n OUTPUT:\n " }, { "from": "agent", "value": "Continuity of Care and Healthcare Costs among Patients with Chronic Disease: Evidence from Primary Care Settings in China." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Drug resistance presents an ever-increasing global public health threat that involves all major microbial pathogens and antimicrobial drugs. Strains that are resistant to multiple drugs pose severe clinical problems and cost lives. However, systematic studies on cross-resistance of \n OUTPUT:\n " }, { "from": "agent", "value": "Molecular Mechanism of " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Lower urinary tract dysfunction often requires tissue repair or replacement to restore physiological functions. Current clinical treatments involving autologous tissues or synthetic materials inevitably bring in situ complications and immune rejection. Advances in therapies using stem cells offer new insights into treating lower urinary tract dysfunction. One of the most frequently used stem cell sources is adipose tissue because of its easy access, abundant source, low risk of severe complications, and lack of ethical issues. The regenerative capabilities of adipose-derived stem cells (ASCs) in vivo are primarily orchestrated by their paracrine activities, strong regenerative potential, multi-differentiation potential, and cell-matrix interactions. Moreover, biomaterial scaffolds conjugated with ASCs result in an extremely effective tissue engineering modality for replacing or repairing diseased or damaged tissues. Thus, ASC-based therapy holds promise as having a tremendous impact on reconstructive urology of the lower urinary tract.\n OUTPUT:\n " }, { "from": "agent", "value": "Therapies Based on Adipose-Derived Stem Cells for Lower Urinary Tract Dysfunction: A Narrative Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Two interacting double quantum dots (DQDs) can be suitable candidates for operation in the applications of quantum information processing and computation. In this work, DQDs are modeled by the heterostructure of two-dimensional (2D) MoS\n OUTPUT:\n " }, { "from": "agent", "value": "Dynamical Behavior of Two Interacting Double Quantum Dots in 2D Materials for Feasibility of Controlled-NOT Operation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The AMP-activated protein kinase (AMPK) is a cellular sensor of energetics and when activated in skeletal muscle during contraction can impart changes in skeletal muscle metabolism. Therapeutics that selectively activate AMPK have been developed to lower glucose levels through increased glucose disposal rates as an approach to abrogate the hyperglycemic state of diabetes; however, the metabolic fate of glucose following AMPK activation remains unclear. We have used a combination of \n OUTPUT:\n " }, { "from": "agent", "value": "AMPK activation is sufficient to increase skeletal muscle glucose uptake and glycogen synthesis but is not required for contraction-mediated increases in glucose metabolism." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Studies suggest that elevated postnatal blood lead levels (BLLs) are negatively associated with child growth. This study aimed to investigate the associations of childhood BLLs at age one year and growth outcomes at age six years (\n OUTPUT:\n " }, { "from": "agent", "value": "Lead Exposure in Infancy and Subsequent Growth in Beninese Children." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The swimming kinematics (how fish move) and dynamics (how forces effect movement) of \n OUTPUT:\n " }, { "from": "agent", "value": "The Kinematics and Dynamics of " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: It is difficult for traditional signal-recognition methods to effectively classify and identify multiple emitter signals in a low SNR environment. This paper proposes a multi-emitter signal-feature-sorting and recognition method based on low-order cyclic statistics CWD time-frequency images and the YOLOv5 deep network model, which can quickly dissociate, label, and sort the multi-emitter signal features in the time-frequency domain under a low SNR environment. First, the denoised signal is extracted based on the low-order cyclic statistics of the typical modulation types of radiation source signals. Second, the time-frequency graph of multisource signals was obtained through CWD time-frequency analysis. The cyclic frequency was controlled to balance the noise suppression effect and operation time to achieve noise suppression of multisource signals at a low SNR. Finally, the YOLOv5s deep network model is used as a classifier to sort and identify the received signals from multiple radiation sources. The method proposed in this paper has high real-time performance. It can identify the radiation source signals of different modulation types with high accuracy under the condition of a low SNR.\n OUTPUT:\n " }, { "from": "agent", "value": "Low SNR Multi-Emitter Signal Sorting and Recognition Method Based on Low-Order Cyclic Statistics CWD Time-Frequency Images and the YOLOv5 Deep Learning Model." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Anxiety-related mental health problems constitute a health challenge, especially in the elderly population. At present, there are few psychological treatments to reduce anxiety adapted to this group. The aim of this study was to conduct a systematic review of the literature to determine the therapeutic effects of Acceptance and Commitment Therapy (ACT) on anxiety in older adults, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. Two blinded reviewers participated in the search, selection and methodological quality assessment processes; reaching satisfactory levels of agreement between reviewers (κ > 0.70). The search was performed in PubMed, Proquest Central, Scopus and Web of Science; making use of standardized terms for the construction of the algorithm. In the general search 348 studies were found. After applying the eligibility criteria and excluding duplicates, seven articles were extracted for qualitative analysis. The total number of subjects was 633, with an average age of 68.89 years (68.94% women). The analysis of methodological rigor showed moderate indices on average. The publications focused primarily on samples with a diagnosis of generalized anxiety disorder, proposing a variety of assessment tests for related dependent variables, especially depressive symptoms and psychological flexibility. Critical analysis of the findings provides evidence for the efficacy of ACT in reducing anxious and depressive symptoms in older adults. This study proposes the use of this procedure as a non-pharmacological alternative for a group usually underrepresented in the scientific literature on this topic.\n OUTPUT:\n " }, { "from": "agent", "value": "Is acceptance and commitment therapy helpful in reducing anxiety symptomatology in people aged 65 or over? A systematic review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cardiac involvement is well documented in thrombotic thrombocytopenic purpura (TTP). Management remains challenging due to thrombocytopenia. Caplacizumab is a novel medication in TTP, but questions remain on its overall benefit in TTP patients. We report a 76-year-old woman who was admitted for non-ST segment elevation myocardial infarction, left systolic ventricular dysfunction, severe hemolytic anemia, and thrombocytopenia suggestive of TTP (PLASMIC score 7). Therapeutic plasma exchange (TPE) and caplacizumab were started alongside an immunosuppressive regimen. After 3 days of treatment, repeat echocardiography showed complete resolution of left ventricular dysfunction. We were able to stop TPE and start aspirin on the fourth day after normalization of platelet count. Our report outlines the potential benefits of caplacizumab for the time-sensitive management of acute coronary syndrome and the compromised volume status of heart failure patients, with early platelet recovery and lower duration of TPE.\n OUTPUT:\n " }, { "from": "agent", "value": "Caplacizumab in the successful management of cardiac involvement in thrombotic thrombocytopenic purpura." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Ischemia-induced angiogenesis is critical for blood flow restoration and tissue regeneration, but the underlying molecular mechanism is not fully understood. ATG7 (autophagy related 7) is essential for classical degradative macroautophagy/autophagy and cell cycle regulation. However, whether and how ATG7 influences endothelial cell (EC) function and regulates post-ischemic angiogenesis remain unknown. Here, we showed that in mice subjected to femoral artery ligation, EC-specific deletion of \n OUTPUT:\n " }, { "from": "agent", "value": "Ablation of endothelial " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Most machine learning-based methods predict outcomes rather than understanding causality. Machine learning methods have been proved to be efficient in finding correlations in data, but unskilful to determine causation. This issue severely limits the applicability of machine learning methods to infer the causal relationships between the entities of a biological network, and more in general of any dynamical system, such as medical intervention strategies and clinical outcomes system, that is representable as a network. From the perspective of those who want to use the results of network inference not only to understand the mechanisms underlying the dynamics, but also to understand how the network reacts to external stimuli (e. g. environmental factors, therapeutic treatments), tools that can understand the causal relationships between data are highly demanded. Given the increasing popularity of machine learning techniques in computational biology and the recent literature proposing the use of machine learning techniques for the inference of biological networks, we would like to present the challenges that mathematics and computer science research faces in generalising machine learning to an approach capable of understanding causal relationships, and the prospects that achieving this will open up for the medical application domains of systems biology, the main paradigm of which is precisely network biology at any physical scale.\n OUTPUT:\n " }, { "from": "agent", "value": "Machine Learning for Causal Inference in Biological Networks: Perspectives of This Challenge." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Malic acid, mainly used as acidulant and taste enhancer in the food industry, is currently produced from fossil resources. In this study, microbial L-malate production with the filamentous fungus \n OUTPUT:\n " }, { "from": "agent", "value": "Effect of process mode, nitrogen source and temperature on L-malic acid production with " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Alcohol affects many neuronal proteins that are upstream or down-stream of synaptic vesicle fusion and neurotransmitter release. Less well studied is alcohol's effect on the fusion machinery including SNARE proteins and lipid membranes. Using a SNARE-driven fusion assay we show that fusion probability is significantly increased at 0.4% v/v (68 mM) ethanol; but not with methanol up to 10%. Ethanol appears to act directly on membrane lipids since experiments focused on protein properties [circular dichroism spectrometry, site-directed fluorescence interference contrast (sdFLIC) microscopy, and vesicle docking results] showed no significant changes up to 5% ethanol, but a protein-free fusion assay also showed increased lipid membrane fusion rates with 0.4% ethanol. These data show that the effects of high physiological doses of ethanol on SNARE-driven fusion are mediated through ethanol's interaction with the lipid bilayer of membranes and not SNARE proteins, and that methanol affects lipid membranes and SNARE proteins only at high doses.\n OUTPUT:\n " }, { "from": "agent", "value": "Drunken lipid membranes, not drunken SNARE proteins, promote fusion in a model of neurotransmitter release." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Corticosteroids have for some time been used as first-line drugs for the topical treatment of noninfectious uveitis, but poor ocular bioavailability and the rapid clearance of eye drops necessitate frequent dosing, reducing patient compliance. In this study, we used an acid-sensitive stearoxyl-ketal-dexamethasone pro-drug microcrystals (SKD MCs), which is consistently safe and effective in the control of uveitis inflammation in rats. We used a rat model of experimental autoimmune uveitis (EAU) to evaluate the effects of SKD MCs in terms of clinical manifestations, molecular biology, pathological histology, and visual electrophysiology compared to dexamethasone sodium phosphate injection or phosphate-buffered saline. SKD MCs significantly reduced inflammation in EAU, improved the ability to suppress inflammatory cytokines and to protect retinal function, and significantly reduced retinal microglia activation, with no increase in intraocular pressure throughout the treatment. Our results indicate that the SKD MCs formulation holds promise as a new strategy for the treatment of noninfectious uveitis and potentially other ocular inflammatory diseases.\n OUTPUT:\n " }, { "from": "agent", "value": "Long-acting acid-sensitive ketal-linked dexamethasone microcrystals for treating experimental autoimmune uveitis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Vinegar is widely used in Chinese diet as a traditional condiment, and its functional component acetic acid has been proposed to prevent obesity, while its mechanism is still unclear. Bile acids (BAs) have been reported to have a protective effect on obesity. This study demonstrated that high-fat diet induced obesity (DIO) seriously disturbed BAs balance by significantly decreasing hepatic BAs synthesis and increasing fecal BAs excretion. However, acetate supplemented in the high-fat diet can restore BAs balance by mainly promoting hepatic taurine conjugated BAs (tauro-BAs) synthesis and decreasing fecal tauro-BAs excretion. The tauro-BAs, as the antagonists, inhibited the intestinal-liver farnesoid X receptor (FXR)-fibroblast growth factor 15 (FGF15)-FGF receptor 4 (FGFR4) signaling pathway, and negatively regulated the production of hepatic BAs. Present study provided important clues for further investigation of the mechanism of acetic acid inhibiting DIO.\n OUTPUT:\n " }, { "from": "agent", "value": "Dietary acetic acid suppress high-fat diet-induced obesity in mice by altering taurine conjugated bile acids metabolism." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: First reports of narcolepsy with cataplexy (NC) in Russia were made by Mankovsky in 1925. The largest series of patients (n=110) was reported by A. Vein in 1964. However, until today narcolepsy remains relatively unknown in Russia. The aim of this study is to report clinical and polysomnography (PSG)/Multiple Sleep Latency Test (MSLT) results in the Russian population and compare them with the European Narcolepsy Network (EU-NN) data (n=1099) reported.\n OUTPUT:\n " }, { "from": "agent", "value": "Clinical and neurophysiological characteristics of 89 patients with narcolepsy and cataplexy from the Russian Narcolepsy Network." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma, a lethal disease lacking specific therapies. This study reports on the identification, characterization, and immunotherapeutic application of HLA-presented neoantigens specific for the DNAJB1-PRKACA fusion transcript in fibrolamellar hepatocellular carcinoma. DNAJB1-PRKACA-derived HLA class I and HLA class II ligands induce multifunctional cytotoxic CD8\n OUTPUT:\n " }, { "from": "agent", "value": "The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This paper presents a polarization calibration method applied to a microwave polarimeter demonstrator based on a near-infrared (NIR) frequency up-conversion stage that allows both optical correlation and signal detection at a wavelength of 1550 nm. The instrument was designed to measure the polarization of cosmic microwave background (CMB) radiation from the sky, obtaining the Stokes parameters of the incoming signal simultaneously, in a frequency range from 10 to 20 GHz. A linearly polarized input signal with a variable polarization angle is used as excitation in the polarimeter calibration setup mounted in the laboratory. The polarimeter systematic errors can be corrected with the proposed calibration procedure, achieving high levels of polarization efficiency (low polarization percentage errors) and low polarization angle errors. The calibration method is based on the fitting of polarization errors by means of sinusoidal functions composed of additive or multiplicative terms. The accuracy of the fitting increases with the number of terms in such a way that the typical error levels required in low-frequency CMB experiments can be achieved with only a few terms in the fitting functions. On the other hand, assuming that the calibration signal is known with the required accuracy, additional terms can be calculated to reach the error levels needed in ultrasensitive B-mode polarization CMB experiments.\n OUTPUT:\n " }, { "from": "agent", "value": "Polarization Calibration of a Microwave Polarimeter with Near-Infrared Up-Conversion for Optical Correlation and Detection." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Radiobiological investigations on the reproductive behavior of female \n OUTPUT:\n " }, { "from": "agent", "value": "Effect of Irradiation on Reproduction of Female " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Field studies were conducted from 2016 to 2019 (south-eastern Poland; 49°58'40.6″ N 22°33'11.3″ E) with the aim to identify the chemical composition of winter wheat grain upon foliar application of biostimulants, of which PlanTonic BIO (containing nettle and willow extracts) showed antifungal activity. The main chemical compositions and their spatial distribution in wheat grain were characterized by Raman spectroscopy technique. It was established that applied biostimulants and hydro-thermal conditions changed the chemical composition of the grain during all the studied years. A similar chemical composition of the grain was achieved in plants treated with synthetic preparations, including both intensive and extensive variants. The second group, in terms of an increase in fatty acid content, consists of grains of plants treated with biostimulants PlanTonic BIO, PlanTonic BIO + Natural Crop and PlanTonic BIO + Biofol Plex. The future of using biostimulants in crop production, including those containing salicylic acid and nettle extracts, appears to be a promising alternative to synthetic crop protection products.\n OUTPUT:\n " }, { "from": "agent", "value": "The Influence of Biostimulants Used in Sustainable Agriculture for Antifungal Protection on the Chemical Composition of Winter Wheat Grain." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Metabolic shifts can occur in cells of the innate immune system in response to microbial infection. Whether these metabolic shifts benefit host defense and propagation of an immune response appears to be context dependent. In an arms race, host-adapted microbes and mammalian cells vie for control of biosynthetic machinery, organelles, and metabolites. Herein, we discuss the intersection of host metabolism and cell-intrinsic immunity with implications for cell fate during infection. Sensation of microbial ligands in isolation results in host metabolic shifts that imbues normal innate immune function, such as cytokine secretion. However, living microbes have an arsenal of effectors and strategies to subvert cell-intrinsic immune responses by manipulating host metabolism. Consequently, host metabolism is monitored as an indicator of invasion or manipulation by a pathogen, primarily through the actions of guard proteins and inflammasome pathways. In this review, we frame initiation of cell-intrinsic immunity in the context of host metabolism to include a physiologic \"Goldilocks zone\" of allowable shifts with guard circuits monitoring wide perturbations away from this zone for the initiation of innate immune responses. Through comparison of studies with purified microbial ligands, dead microbes, and live pathogens we may begin to understand how shifts in metabolism determine the outcome of host-pathogen interactions.\n OUTPUT:\n " }, { "from": "agent", "value": "Biting the hand that feeds: Metabolic determinants of cell fate during infection." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Occupational exposures have been regarded as a risk factor for the development of chronic obstructive pulmonary disease (COPD). However, there is little knowledge regarding the effect of occupational exposure on the treatment outcomes of COPD. Therefore, the aim of this study was to evaluate the question of whether occupational exposure can have a potential impact on COPD outcomes. \n OUTPUT:\n " }, { "from": "agent", "value": "Impact of Previous Occupational Exposure on Outcomes of Chronic Obstructive Pulmonary Disease." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Extracellular vesicles (EVs) are highly promising as drug delivery vehicles due to their nanoscale size, stability and biocompatibility. EVs possess natural targeting abilities and are known to traverse long distances to reach their target cells. This long-range organotropism and the ability to penetrate hard-to-reach tissues, including the brain, have sparked interest in using EVs for the targeted delivery of pharmaceuticals. In addition, EVs can be readily harvested from an individual's biofluids, making them especially suitable for personalized medicine applications. However, the targeting abilities of unmodified EVs have proven to be insufficient for clinical applications. Multiple attempts have been made to bioengineer EVs to fine-tune their on-target binding. Here, we summarize the current state of knowledge on the natural targeting abilities of native EVs. We also critically discuss the strategies to functionalize EV surfaces for superior long-distance targeting of specific tissues and cells. Finally, we review the challenges in achieving specific on-target binding of EV nanocarriers.\n OUTPUT:\n " }, { "from": "agent", "value": "Targeting Capabilities of Native and Bioengineered Extracellular Vesicles for Drug Delivery." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Artificially-induced defects in the lattice of graphene are a powerful tool for engineering the properties of the crystal, especially if organized in highly-ordered structures such as periodic arrays. A method to deterministically induce defects in graphene is to irradiate the crystal with low-energy (&lt;20 keV) electrons delivered by a scanning electron microscope. However, the nanometric precision granted by the focused beam can be hindered by the pattern irradiation itself due to the small lateral separation among the elements, which can prevent the generation of sharp features. An accurate analysis of the achievable resolution is thus essential for practical applications. To this end, we investigated patterns generated by low-energy electron irradiation combining atomic force microscopy and micro-Raman spectroscopy measurements. We proved that it is possible to create well-defined periodic patterns with precision of a few tens of nanometers. We found that the defected lines are influenced by electrons back-scattered by the substrate, which limit the achievable resolution. We provided a model that takes into account such substrate effects. The findings of our study allow the design and easily accessible fabrication of graphene devices featuring complex defect engineering, with a remarkable impact on technologies exploiting the increased surface reactivity.\n OUTPUT:\n " }, { "from": "agent", "value": "Periodic Structural Defects in Graphene Sheets Engineered via Electron Irradiation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The use of single-atom catalysts is a promising approach to solve the issues of polysulfide shuttle and sluggish conversion chemistry in lithium-sulfur (Li-S) batteries. However, a single-atom catalyst usually contains a low content of active centers because more metal ions lead to generation of aggregation or the formation of nonatomic catalysts. Herein, a 2D conductive metal-organic framework [Co\n OUTPUT:\n " }, { "from": "agent", "value": "Electrostatic Potential-Induced Co-N" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The IMPACT study established the role of controlled esophageal cooling in preventing esophageal thermal injury during radiofrequency (RF) ablation for atrial fibrillation (AF). The effect of esophageal cooling on ablation lesion delivery and procedural and patient outcomes had not been previously studied. The objective was to determine the effect of esophageal cooling on the formation of RF lesions, the ability to achieve procedural endpoints, and clinical outcomes.\n OUTPUT:\n " }, { "from": "agent", "value": "Effect of esophageal cooling on ablation lesion formation in the left atrium: Insights from Ablation Index data in the IMPACT trial and clinical outcomes." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Li-Fraumeni-syndrome (LFS) is a rare, highly penetrant cancer predisposition syndrome (CPS) caused by pathogenic variants (PVs) in \n OUTPUT:\n " }, { "from": "agent", "value": "Health Behavior and Cancer Prevention among Adults with Li-Fraumeni Syndrome and Relatives in Germany-A Cohort Description." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Comprehensive pathology reporting of cancers is important for patient management, tumor staging, and prognostication. Standardized cancer datasets are essential in guiding pathology reporting in a consistent and concise manner and this facilitates effective global cancer information exchange and comparison. The International Collaboration on Cancer Reporting (ICCR) is an alliance of several national and international pathology societies in many countries as well as bodies which are involved in tumor classification and staging. One function of the ICCR is to develop evidence-based, standardized reporting datasets for each cancer site. Herein, we report the development of an evidence-based cancer dataset by an ICCR panel of international experts for the reporting of primary uterine gestational trophoblastic neoplasia. We present the core elements that should be included and noncore elements that are recommended for inclusion in pathology reports. Lists of the response values are provided for each element, along with explanatory commentaries. The dataset also discusses controversial issues in the reporting of gestational trophoblastic neoplasia. Such evidence-based and structured pathology datasets developed through an international effort will facilitate consistent and accurate exchange and comparison of epidemiological and pathologic parameters among different populations and countries. This will ultimately improve gestational trophoblastic neoplasia patient care and facilitate future research.\n OUTPUT:\n " }, { "from": "agent", "value": "Dataset for the Reporting of Gestational Trophoblastic Neoplasia: Recommendations From the International Collaboration on Cancer Reporting (ICCR)." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: There is a well-known association between the connective tissue disorders (CTDs) and lung disease. In addition to interstitial lung disease, the CTDs may affect the air spaces and pulmonary vasculature. Imaging tests are important not only in diagnosis but also in management of these complex disorders. In the present review, key aspects of the imaging of CTD-reated diseases are discussed.\n OUTPUT:\n " }, { "from": "agent", "value": "Imaging of Lung Disease Associated with Connective Tissue Disease." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: There is a widely recognized need to increase funding available for improving nutrition in low- and middle-income countries and to move beyond traditional grants from development agencies and private foundations. This includes the so-called innovative financing approaches, such as impact investment (i.e., investing with the intent to generate positive social impact). Impact investment is no substitute for much-needed public funding to support direct nutrition interventions, but such approaches could make sense where supporting nutrition entails a \"business case\" that could create profit for a business-thus fostering the positive returns needed by investors. This includes some food-based approaches, as most households purchase food from for-profit companies and entrepreneurs. Investment in firms that produce nutritious foods for local markets could be profitable and-if it were to improve food affordability, accessibility, or desirability-could help improve diet quality. In this Perspective, we describe these innovative financing mechanisms and discuss their potential for supporting nutritious foods. We note that doing so would require a simple yet evidence-based approach to screening nutritious foods for potential investment, and we describe our experience operationalizing this through a novel nutrition impact investment mechanism: the Nutritious Foods Financing Facility. We conclude by highlighting remaining gaps to explore the potential of impact investment in nutrition and what the nutrition community can do to help fill them-and to mitigate the risk of such approaches being applied in ways that do not lead to positive social impact for nutrition.\n OUTPUT:\n " }, { "from": "agent", "value": "Impact Investing Holds Promise for Nutrition If Guided by Evidence." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Children in hospitals endure a variety of stressful situations. Children feel friendly toward and have fun with robots. Care robots are considered to be an alternate technique to relieve stress after hospitalization. A mixed-methods study was conducted on caregivers to understand the ideal care robot. One hundred and fifty caregivers of pediatric patients participated in a quantitative online survey, and eleven participated in focus group interviews for qualitative analysis. Quantitative data underwent descriptive statistics. Content analysis was conducted for qualitative data. Regarding the overall awareness and necessity of a care robot, the caregivers thought it would help patients adapt to the hospital environment more quickly. The caregivers' preferred character-shaped robots of child height. For sound, they preferred an animated character's voice. For movement, they preferred the robot to roll on wheels. Regarding functions, medicine was the item for which they most wanted to use game elements. For the educational element, the caregivers wanted to teach children the reasons for and methods of medicine administration. Four themes were derived from the qualitative results. The findings are expected to contribute to the future development of care robots that can assist pediatric patients.\n OUTPUT:\n " }, { "from": "agent", "value": "Caregiver Views on Prospective Use of Robotic Care in Helping Children Adapt to Hospitalization." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Dihydroartemisinin (DHA), a widely used antimalarial agent, has clinical potential for the treatment of hepatic carcinoma. Although chemotherapy is indispensable for tumor therapy, it is generally limited by poor solubility, low efficiency, rapid clearance, and side effects. As an emerging treatment method, photothermal therapy (PTT) has many outstanding properties, but suffers from poor photostability of photosensitizer and incomplete ablation. Multimodal therapies could combine the advantages of different therapy methods to improve antitumor efficiency. Hence, we designed a nano-delivery system (ICG&DHA@ZIF-8) using zeolitic imidazolate framework-8 (ZIF-8) with a high porous rate and pH sensitivity property, to co-load DHA and indocyanine green (ICG). Dynamic light scattering and transmission electron microscopy were used to characterize the prepared nanoparticles. The photothermal conversion and drug release performances of ICG&DHA@ZIF-8 were investigated. In vitro antitumor efficacy and cellular uptake were studied. The mechanism of the combination treatment was studied by reactive oxygen species level detection and western blot assays. In vivo antitumor assays were then studied with the guidance of ex vivo imaging. The results showed that the ICG&DHA@ZIF-8 based combination therapy could efficiently kill hepatic carcinoma cells and suppress tumor growth. This research provides a potential nanodrug for the treatment of hepatic carcinoma.\n OUTPUT:\n " }, { "from": "agent", "value": "Co-Delivery of Dihydroartemisinin and Indocyanine Green by Metal-Organic Framework-Based Vehicles for Combination Treatment of Hepatic Carcinoma." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Glioblastoma remains the most lethal form of brain cancer, where hybrid nanomaterials biofunctionalized with polysaccharide peptides offer disruptive strategies relying on passive/active targeting and multimodal therapy for killing cancer cells. Thus, in this research, we report for the first time the rational design and synthesis of novel hybrid colloidal nanostructures composed of gold nanoparticles stabilized by trisodium citrate (AuNP@TSC) as the oxidase-like nanozyme, coupled with cobalt-doped superparamagnetic iron oxide nanoparticles stabilized by carboxymethylcellulose ligands (Co-MION@CMC) as the peroxidase-like nanozyme. They formed inorganic-inorganic dual-nanozyme systems functionalized by a carboxymethylcellulose biopolymer organic shell, which can trigger a biocatalytic cascade reaction in the cancer tumor microenvironment for the combination of magnetothermal-chemodynamic therapy. These nanoassemblies were produced through a \n OUTPUT:\n " }, { "from": "agent", "value": "Bioengineered Carboxymethylcellulose-Peptide Hybrid Nanozyme Cascade for Targeted Intracellular Biocatalytic-Magnetothermal Therapy of Brain Cancer Cells." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: A 58-year-old man presented to his practitioner with right-sided pleuritic chest pain, dyspnea, and fatigue 18 days following the first dose of the ChAdOx1 nCov-19 vaccine. Chest radiography showed a basal wedge-shaped consolidation indicative of a Hampton's hump in the right lower lobe, which was confirmed by subsequent computed tomography pulmonary angiography. The major laboratory abnormalities were a markedly elevated D-dimer level of 7.53 µg/mL (normal range &lt; 0.5 µg/mL), a CRP level of 62.8 mg/L (normal range &lt; 5 mg/L), and a previously unknown activated protein C resistance of 1.3 (normal range ≥ 1.8). Genetic analysis identified the patient to be heterozygous for the FV\n OUTPUT:\n " }, { "from": "agent", "value": "Temporal Association between Hampton's Hump Pulmonary Embolism and First-Dose ChAdOx1 nCov-19 Vaccine in a Patient with Activated Protein C Resistance." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: African Swine Fever (ASF) causes high mortality and often results in strict culling policies for affected pigs and international market restrictions. It took more than 25 years for swine inventories in Haiti and the Dominican Republic to recover from an ASF outbreak that took place from 1978 to 1984. The 2021 outbreaks in the Dominican Republic and Haiti pose threats to animal health, livestock markets, and producer livelihoods. A partial equilibrium Haitian pig sector model (HPM-2021) was developed to assess the economic impacts of a 2021 Haitian ASF outbreak of a similar size to the 1980s outbreak. The dynamic model examines ASF impacts from 2021 to 2024, through 100 iterations of stochastic supply shocks, and three specific demand shocks. Recovery alternatives are assessed through 2030, and outbreaks and recovery outcomes are compared to a baseline reflecting 2019 trends. The analysis includes economic effects on national pork and maize in Haiti, the Dominican Republic, the rest of the Caribbean, and the rest of the world. Findings demonstrate higher vulnerabilities of the traditional sector to ASF-related disruptions. The inflated prices generated by pork production shortfalls are an opportunity to accelerate income growth for remaining traditional pig producers. When there is no consumer avoidance, the production losses caused by ASF generate high prices and contribute to a minimum of 49% increase in traditional sector revenue, and a minimum of 2.22% revenue growth in the commercial sector from the 2019 base year. Nevertheless, the potential for consumer avoidance of pork cause prices to decrease and offset those gains by as much as 90% in the traditional sector and 44% in the commercial sector. Smaller commercial sector impacts derive from different elasticities. ASF-induced high prices also lead to increased consumer expenditure losses by up to 200% over the outbreak period. Nevertheless, consumer expenditures tend to recover instantaneously with ASF eradication. Due to persisting demand shocks, producers will earn up to 0.3% lower than baseline levels income from 2027 to 2030. Few models evaluate the economic impacts of health response policies in less developed countries like Haiti. HPM-2021 results highlight ASF impacts on prices, which can benefit certain producers and disincentivize on-farm disease reporting. Slow recovery and consumer avoidance of pork are detrimental to long-term swine industry survival, producer livelihoods, and the overall rural economy.\n OUTPUT:\n " }, { "from": "agent", "value": "An analysis of African Swine Fever consequences on rural economies and smallholder swine producers in Haiti." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Two decades after reports of the anti-pruritic effects of botulinum neurotoxins (BoNTs), there is still no approved product for the anti-itch indication of BoNTs, and most clinical case reports still focus on the off-label use of BoNTs for various itchy conditions. Few randomized clinical trials have been conducted with controversial results, and the beneficial effects of BoNTs against itch are mainly based on case studies and case series. These studies are valuable in presenting the potential application of BoNTs in chronic pruritic conditions, but due to the nature of these studies, they are categorized as providing lower levels of evidence or lower grades of recommendation. To obtain approval for the anti-pruritic indication of BoNTs, higher levels of evidence are required, which can be achieved through conducting large-scale and well-designed studies with proper control groups and established careful and reliable primary and secondary outcomes. In addition to clinical evidence, presenting the mechanism-based antipruritic action of BoNTs can potentially strengthen, accelerate, and facilitate the current efforts towards further investments in accelerating the field towards the potential approval of BoNTs for itchy conditions. This review, therefore, aimed to provide the state-of-the-art mechanisms underlying the anti-itch effect of BoNTs from basic studies that resemble various clinical conditions with itch as a hallmark. Evidence of the neuronal, glial, and immune modulatory actions of BoNTs in reducing the transmission of itch are presented, and future potential directions are outlined.\n OUTPUT:\n " }, { "from": "agent", "value": "How Does Botulinum Toxin Inhibit Itch?" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: We propose a Vision-Language Transformer (VLT) framework for referring segmentation to facilitate deep interactions among multi-modal information and enhance the holistic understanding to vision-language features. There are different ways to understand the dynamic emphasis of a language expression, especially when interacting with the image. However, the learned queries in existing transformer works are fixed after training, which cannot cope with the randomness and huge diversity of the language expressions. To address this issue, we propose a Query Generation Module, which dynamically produces multiple sets of input-specific queries to represent the diverse comprehensions of language expression. To find the best among these diverse comprehensions, so as to generate a better mask, we propose a Query Balance Module to selectively fuse the corresponding responses of the set of queries. Furthermore, to enhance the model's ability in dealing with diverse language expressions, we consider inter-sample learning to explicitly endow the model with knowledge of understanding different language expressions to the same object. We introduce masked contrastive learning to narrow down the features of different expressions for the same target object while distinguishing the features of different objects. The proposed approach is lightweight and achieves new state-of-the-art referring segmentation results consistently on five datasets.\n OUTPUT:\n " }, { "from": "agent", "value": "VLT: Vision-Language Transformer and Query Generation for Referring Segmentation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To evaluate the clinical performance of self-assembling peptides versus fluoride-based delivery systems in post-orthodontic white spot lesions.\n OUTPUT:\n " }, { "from": "agent", "value": "Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The prognosis of gastric cancer in an advanced stage remains poor. The exact efficacy of the use of intraoperative sustained-release chemotherapy with 5-fluorouracil (5-FU) in advanced-stage gastric cancer is still unelucidated.\n OUTPUT:\n " }, { "from": "agent", "value": "No long-term survival benefit with sustained-release 5-fluorouracil implants in patients with stages II and III gastric cancer." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Tissue engineering is one of the most important medical rehabilitation tools that includes two vital components of scaffolding and cell growth stimulants. Therefore, designing a more intelligent, portable, monitorable, and safe scaffold that can release growth factors is a key step in achieving an acceptable level of cells for treating patients. In this study, a nanofibers-grafted scaffold was prepared with two-nozzle electrospinning to serve as a tissue engineering scaffold. Fundamental physical characterizations were carried out by scanning electron microscopy (SEM), pore diameter determination, and FT-IR. Fundamental physical characterization revealed that the nanofibers-scaffolds grafted with Royal Jelly significantly increased hydrophilicity, but the porosity of the novel-nanofibers did not alter significantly than the nanofibers without Royal Jelly. Based on the MTT assay results, cell growth, survival, and proliferation of the HUVEC Cell line were increased in the nanofibers scaffold grafted with Royal Jelly. Together, these findings highlight the potential of our novel scaffold for tissue engineering applications.\n OUTPUT:\n " }, { "from": "agent", "value": "A novel 3D-electrospun nanofibers-scaffold grafted with Royal Jelly: improve hydrophilicity of the nanofibers-scaffold and proliferation of HUVEC cell line." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: A growing body of research suggests disinhibited eating and weaker executive function (EF) are two risk factors for pediatric obesity. Emerging brain imaging and behavioral findings support the notion that EF skills impact eating regulation. However, a major gap in the current literature is a synthesis of the association between various EF skills and disinhibited eating patterns across child development. To address this gap, a systematic review and meta-analysis was conducted to examine the effect of EF skills on disinhibited eating behaviors among youth ages 3-18 years old. PubMed and PsychINFO databases were utilized and data from 15 studies with a total sample of 4909 youth were included. A random effects meta-analysis revealed a small negative effect of overall EF skills on disinhibited eating behavior, \n OUTPUT:\n " }, { "from": "agent", "value": "Disinhibited Eating and Executive Functioning in Children and Adolescents: A Systematic Review and Meta-Analysis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: COVID-19 has infected millions of people worldwide over the past few years. The main technique used for COVID-19 detection is reverse transcription, which is expensive, sensitive, and requires medical expertise. X-ray imaging is an alternative and more accessible technique. This study aimed to improve detection accuracy to create a computer-aided diagnostic tool. Combining other artificial intelligence applications techniques with radiological imaging can help detect different diseases. This study proposes a technique for the automatic detection of COVID-19 and other chest-related diseases using digital chest X-ray images of suspected patients by applying transfer learning (TL) algorithms. For this purpose, two balanced datasets, Dataset-1 and Dataset-2, were created by combining four public databases and collecting images from recently published articles. Dataset-1 consisted of 6000 chest X-ray images with 1500 for each class. Dataset-2 consisted of 7200 images with 1200 for each class. To train and test the model, TL with nine pretrained convolutional neural networks (CNNs) was used with augmentation as a preprocessing method. The network was trained to classify using five classifiers: two-class classifier (normal and COVID-19); three-class classifier (normal, COVID-19, and viral pneumonia), four-class classifier (normal, viral pneumonia, COVID-19, and tuberculosis (Tb)), five-class classifier (normal, bacterial pneumonia, COVID-19, Tb, and pneumothorax), and six-class classifier (normal, bacterial pneumonia, COVID-19, viral pneumonia, Tb, and pneumothorax). For two, three, four, five, and six classes, our model achieved a maximum accuracy of 99.83, 98.11, 97.00, 94.66, and 87.29%, respectively.\n OUTPUT:\n " }, { "from": "agent", "value": "Classification and Detection of COVID-19 and Other Chest-Related Diseases Using Transfer Learning." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Polaritons - hybrid light-matter states formed in cavity - strongly change the properties of the underlying matter. In optical or plasmonic nanocavities, polaritons decay by radiative emission of the cavity, which is accessible experimentally. Due to the interaction of a molecule with the quantized radiation field, polaritons exhibit light-induced conical intersections (LICIs) which dramatically influence the nuclear dynamics of molecular polaritons. We show that ultrafast radiative emission from the lower polariton is controlled by the geometric phase imposed by the LICI. This finding provides insight into the process of emission and, furthermore, allows one to compute these signals by augmenting the Born-Oppenheimer approximation for polaritons with a geometric phase term.\n OUTPUT:\n " }, { "from": "agent", "value": "Radiative emission of polaritons controlled by light-induced geometric phase." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Endovascular treatment (EVT) for acute large vessel occlusion has proven to be effective in randomized controlled trials. We conducted a prospective cohort study to evaluate the real-world efficacy of EVT in a metropolitan area with a large number of comprehensive stroke centers and to compare it with the results of other registries and randomized controlled trials (RCTs).\n OUTPUT:\n " }, { "from": "agent", "value": "Primary results of mechanical thrombectomy for acute ischemic stroke: The K-NET registry in the Japanese metropolitan area." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Forest fragments consist of important ecosystems for the maintenance of sand fly populations and Leishmania hosts. This study sought to identify the phlebotomine fauna and its infection by Leishmania spp. in forest fragments on the campus of the Federal University of Acre (UFAC), Western Amazon. Monthly collections with CDC traps were carried out from March 2020 to June 2021, in four forest fragments of UFAC. Male and female insects were processed and identified at species level. A sample of females was subjected to polymerase chain reaction (PCR) analysis to verify the presence Leishmania DNA. In total, 465 specimens were collected, of which 238 were males and 227 were females. The most frequent species were Nyssomyia antunesi (Coutinho, 1939) (47.3%), Trichophoromyia sp. (Mangabeira, 1942) (18.70%), and Ny. whitmani (Antunes & Coutinho, 1939) (8.81%). Molecular analysis detected the presence of Leishmania (Ross, 1903) DNA in a specimen of Ny. antunesi, and another one of Evandromyia walker (Newstead, 1914). The forest fragments of the university campus harbor a diverse sand fly fauna with the presence of Leishmania DNA in these insects, in addition to the presence of other species considered incriminated vectors of Leishmania parasites.\n OUTPUT:\n " }, { "from": "agent", "value": "Phlebotomine Fauna (Diptera: Psychodidae) and Infection by Leishmania spp. in Forest Fragments of a University Campus, Western Amazon." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study aimed to screen different winter wheat genotypes at the onset of metabolic changes induced by water deficit to comprehend possible adaptive features of photosynthetic apparatus function and structure to physiological drought. The drought treatment was the most influential variable affecting plant growth and relative water content, and genotype variability determined with what intensity varieties of winter wheat seedlings responded to water deficit. PEG-induced drought, as expected, changed phenomenological energy fluxes and the efficiency with which an electron is transferred to final PSI acceptors. Based on the effect size, fluorescence parameters were grouped to represent photochemical parameters, that is, the donor and acceptor side of PSII (PC1); the thermal phase of the photosynthetic process, or the electron flow around PSI, and the chain of electrons between PSII and PSI (PC2); and phenomenological energy fluxes per cross-section (PC3). Furthermore, four distinct clusters of genotypes were discerned based on their response to imposed physiological drought, and integrated analysis enabled an explanation of their reactions' specificity. The most reliable JIP-test parameters for detecting and comparing the drought impact among tested genotypes were the variable fluorescence at K, L, I step, and PI\n OUTPUT:\n " }, { "from": "agent", "value": "PEG-induced physiological drought for screening winter wheat genotypes sensitivity - integrated biochemical and chlorophyll " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study aimed to evaluate snack food-group composition by weight status among United States adolescents.\n OUTPUT:\n " }, { "from": "agent", "value": "Association of weight status with the types of foods consumed at snacking occasions among US adolescents." } ]