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[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Telemedicine is becoming routine in health care. Postpandemic, a universal return to face-to-face consultations may risk a loss of some of the advantages of telemedicine. However, rapid implementation and adoption without robust evaluation of usability, efficacy, and effectiveness could potentially lead to suboptimal health outcomes and downstream challenges to providers.\n OUTPUT:\n " }, { "from": "agent", "value": "Use of Telemedicine in Pediatric Services for 4 Representative Clinical Conditions: Scoping Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Considering the rapid increase in the population over the age of 65, there is increasing need to consider models of care for persons with dementia (PWD). One common deficit associated with dementia progression is difficulty with successful participation in mealtimes. Difficulty participating in mealtimes in PWD is not the result of one factor, but rather a confluence of biological, psychological, and social characteristics common in dementia. Factors leading to mealtime difficulties for PWD may include changes in cognitive status, altered sensorimotor functioning, and increased reliance on caregiver support. The complex nature of biological, psychological, and social factors leading to mealtime difficulty highlights the need for a pragmatic model that caregivers can utilize to successfully support PWD during mealtimes. Existing models of dementia and mealtime management were reviewed and collated to create a model of mealtime management that considers this complex interplay. The Biopsychosocial Model of Mealtime Management builds on past research around patient-centered care and introduces an asset-based approach to capitalize on a PWD's retained capabilities as opposed to compensating for disabilities associated with dementia. We hope this model will provide a framework for caregivers to understand what factors impact mealtime participation in PWD and provide appropriate means on intervention.\n OUTPUT:\n " }, { "from": "agent", "value": "A Biopsychosocial Model of Mealtime Management in Persons with Dementia, an Asset-Based Approach to Patient-Centered Care." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Medulloblastoma (MB) is a heterogeneous disease in which survival is highly affected by the underlying subgroup-specific characteristics. Although the current treatment modalities have increased the overall survival rates of MB up to 70-80%, MB remains a major cause of cancer-related mortality among children. This indicates that novel therapeutic approaches against MB are needed. New promising treatment options comprise the targeting of cells and components of the tumor microenvironment (TME). The TME of MB consists of an intricate multicellular network of tumor cells, progenitor cells, astrocytes, neurons, supporting stromal cells, microglia, immune cells, extracellular matrix components, and vasculature systems. In this review, we will discuss all the different components of the MB TME and their role in MB initiation, progression, metastasis, and relapse. Additionally, we briefly introduce the effect that age plays on the TME of brain malignancies and discuss the MB subgroup-specific differences in TME components and how all of these variations could affect the progression of MB. Finally, we highlight the TME-directed treatments, in which we will focus on therapies that are being evaluated in clinical trials.\n OUTPUT:\n " }, { "from": "agent", "value": "The Tumor Microenvironment of Medulloblastoma: An Intricate Multicellular Network with Therapeutic Potential." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Self-assembled-assisted ternary nanocomposite In\n OUTPUT:\n " }, { "from": "agent", "value": "Comparative and Efficient Ammonia Gas Sensing Study with Self-assembly-Synthesized Metal Oxide-SiC Fiber-Based Mesoporous SiO" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Health-related expectations regarding aging is a gerontological construct that is potentially predictive of morbidity and mortality in later life. The Expectations Regarding Ageing scale (ERA-12) is a widely used measure of health-related expectations, although it has not previously been administered in Japanese. The present research aimed to elucidate the psychometric properties of the first Japanese translation of the ERA-12 and evaluate health-related expectations among middle-aged and older Japanese.\n OUTPUT:\n " }, { "from": "agent", "value": "Health-Related Expectations Regarding Aging among Middle-Aged and Older Japanese: Psychometric Performance and Novel Findings from the ERA-12-J." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: [This corrects the article DOI: 10.1016/j.rcsop.2021.100038.].\n OUTPUT:\n " }, { "from": "agent", "value": "Erratum to \"A qualitative exploration of the impact of knowledge and perceptions about hypertension in medication adherence in Middle Eastern refugees and migrants\" [Exploratory Research in Clinical and Social Pharmacy 3C (2021) 100038]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study aimed to determine the therapeutic effect of equol (EQ) on osteoporotic osteoarthritis (OP OA).\n OUTPUT:\n " }, { "from": "agent", "value": "Protective effects of equol on the cartilage and subchondral bone in ovariectomized rats with osteoarthritis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Although a facile route to prepare AgCu nanoalloys (NAs) with enhanced antibacterial efficacy using Ag NP catalysis of Cu ions at elevated temperatures was previously developed, its detailed reaction process is still unclear due to the fast reaction process at higher temperatures. This work found that AgCu NAs can also be synthesized by the same process but at room temperature. AgCu NAs formation kinetics have been studied using UV-Visible spectra and Transmission Electron Microscopy (TEM), where formation includes Cu\n OUTPUT:\n " }, { "from": "agent", "value": "AgCu NP Formation by the Ag NP Catalysis of Cu Ions at Room Temperature and Their Antibacterial Efficacy: A Kinetic Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Colorectal cancer (CRC) is one of the most commonly diagnosed human malignancies. Ribosomal protein L31 (RPL31, aka eL31) is a component of the 60S large ribosomal subunit, and its expression pattern and functional role in CRC have not been reported.\n OUTPUT:\n " }, { "from": "agent", "value": "Silencing eL31 suppresses the progression of colorectal cancer via targeting DEPDC1." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Two-dimensional (2D) nanomaterials hold great potential for cancer theranostic applications, yet their clinical translation faces great challenges of high toxicity and limited therapeutic/diagnostic modality. Here, we have created a kind of symbiotic 2D carbon-2D clay nanohybrids, which are composed of a novel 2D carbon nanomaterial (carbon nanochips, or CNC), prepared by carbonizing a conjugated polymer polydiiodobutadiyne, and a 2D layered aluminosilicate clay mineral montmorillonite (MMT). Intriguingly, with the formation of the nanohybrids, MMT can help the dispersion of CNC, while CNC can significantly reduce the hemolysis and toxicity of MMT. The symbiotic combination of CNC and MMT also leads to a synergistic anti-cancer theranostic effect. CNC has a strong absorption and high photothermal conversion efficiency in the second near-infrared region (NIR-II, 1000-1700 nm), while MMT contains Fe\n OUTPUT:\n " }, { "from": "agent", "value": "Near-Infrared-II Activatable Symbiotic 2D Carbon-Clay Nanohybrids for Dual Imaging-Guided Combinational Cancer Therapy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Proper brain development requires the precise coordination and orchestration of various molecular and cellular processes and dysregulation of these processes can lead to neurological diseases. In the past decades, post-transcriptional regulation of gene expression has been shown to contribute to various aspects of brain development and function in the central nervous system. MicroRNAs (miRNAs), short non-coding RNAs, are emerging as crucial players in post-transcriptional gene regulation in a variety of tissues, such as the nervous system. In recent years, miRNAs have been implicated in multiple aspects of brain development, including neurogenesis, migration, axon and dendrite formation, and synaptogenesis. Moreover, altered expression and dysregulation of miRNAs have been linked to neurodevelopmental and psychiatric disorders. Magnetic resonance imaging (MRI) is a powerful imaging technology to obtain high-quality, detailed structural and functional information from the brains of human and animal models in a non-invasive manner. Because the spatial expression patterns of miRNAs in the brain, unlike those of DNA and RNA, remain largely unknown, a whole-brain imaging approach using MRI may be useful in revealing biological and pathological information about the brain affected by miRNAs. In this review, we highlight recent advancements in the research of miRNA-mediated modulation of neuronal processes that are important for brain development and their involvement in disease pathogenesis. Also, we overview each MRI technique, and its technological considerations, and discuss the applications of MRI techniques in miRNA research. This review aims to link miRNA biological study with MRI analytical technology and deepen our understanding of how miRNAs impact brain development and pathology of neurological diseases.\n OUTPUT:\n " }, { "from": "agent", "value": "microRNA Biology on Brain Development and Neuroimaging Approach." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Short-term load forecasting is viewed as one promising technology for demand prediction under the most critical inputs for the promising arrangement of power plant units. Thus, it is imperative to present new incentive methods to motivate such power system operations for electricity management. This paper proposes an approach for short-term electric load forecasting using long short-term memory networks and an improved sine cosine algorithm called MetaREC. First, using long short-term memory networks for a special kind of recurrent neural network, the dispatching commands have the characteristics of storing and transmitting both long-term and short-term memories. Next, four important parameters are determined using the sine cosine algorithm base on a logistic chaos operator and multilevel modulation factor to overcome the inaccuracy of long short-term memory networks prediction, in terms of the manual selection of parameter values. Moreover, the performance of the MetaREC method outperforms others with regard to convergence accuracy and convergence speed on a variety of test functions. Finally, our analysis is extended to the scenario of the MetaREC_long short-term memory with back propagation neural network, long short-term memory networks with default parameters, long short-term memory networks with the conventional sine-cosine algorithm, and long short-term memory networks with whale optimization for power load forecasting on a real electric load dataset. Simulation results demonstrate that the multiple forecasts with MetaREC_long short-term memory can effectively incentivize the high accuracy and stability for short-term power load forecasting.\n OUTPUT:\n " }, { "from": "agent", "value": "Individualized Short-Term Electric Load Forecasting Using Data-Driven Meta-Heuristic Method Based on LSTM Network." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Scleral lenses rely on the scleroconjunctival region without bearing the cornea, which could improve the symptoms and modify the corneal nerve plexus morphology.\n OUTPUT:\n " }, { "from": "agent", "value": "Corneal Confocal Analysis after Scleral Lens Wear in Keratoconus Patients: A Pilot Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Pregnancy is one of the most challenging processes the human body is exposed to: the healthy mother can carry to term a genetically different new-born, while her immune system adapts to tolerate this new status and avoids rejection. In autoimmune disorders, motherhood is even more challenging, with additional medical counselling, mother care, and foetus development checks being necessary. While the aspects of supplementary mother care and pregnancy progress tracking are associated with well-established medical procedures and protocols, counselling, be it pre- or post-conception, is still underestimated and scarcely applied. Indeed, over the past decades, medical counselling for this particular population has changed significantly, but from a healthcare's provider point of view, more is required to ensure a smooth, controllable pregnancy evolution. One of the most frequent autoimmune diseases affecting young females during their fertile years is Systemic Lupus Erythematosus (SLE). Like other heterogenous diseases, it exposes the mother to severe, organ-threatening complications and unpredictable evolution. Both the disease and its treatment can significantly affect the mother's willingness to engage in a potentially risky pregnancy, as well as the likeliness to carry it to term without any impairments. A good collaboration between the patient's rheumatologist and obstetrician is therefore mandatory in order to: (a) allow the mother to make an informed decision on pursuing with the pregnancy; (b) ensure a perfect synchronization between pregnancy terms and treatment; and (c) avoid or minimize potential complications. The best approach to achieve these outcomes is pregnancy planning. Moreover, knowing one desired prerequisite for a successful pregnancy evolution in SLE mothers is a stable, inactive, quiescent disease for at least six months prior to conception, planning becomes more than a recommended procedure. One particular aspect that requires attention before conception is the treatment scheme applied before delivery as autoantibodies can influence significantly the course of pregnancy. In this view, future SLE mothers should ideally benefit from preconception counselling within their agreed care pathway. A multidisciplinary team including at least the rheumatologist and obstetrician should be employed throughout the pregnancy, to decide on the appropriate timing of conception and compatible medication with respect to disease activity, as well as to monitor organ involvement and foetus development progress.\n OUTPUT:\n " }, { "from": "agent", "value": "Preparing for Pregnancy in Women with Systemic Lupus Erythematosus-A Multidisciplinary Approach." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Atrazine, one of the most commonly used herbicides in the world, is of concern because of its frequent occurrence in various water bodies and the potential threat it constitutes to ecosystems. The transport of contaminants in seasonally ice-covered lakes is an important factor affecting the under-ice water environment, and changes in phase during ice growth and melting cause redistribution of atrazine between ice and water phases. To explore the migration pattern of atrazine during freezing and thawing, laboratory simulation experiments involving freezing and thawing were carried out. The effects of ice thickness, freezing temperature, and initial concentration on the migration ability of atrazine during freezing were investigated. The results showed that the relationship between the concentration of atrazine in ice and water during freezing was ice layer < water before freezing < water layer under the ice. Atrazine tended to migrate to under-ice water during the freezing process, and the intensity of migration was positively correlated with the ice thickness, freezing temperature, and initial concentration. During the thawing phase, atrazine trapped in the ice was released into the water in large quantities in the early stages. The first 20% of meltwater concentration was significantly higher than the average concentration in ice, with the highest case being 2.75 times the average concentration in ice. The results reported in this study are a useful reference for planning possible pollution control measures on such lakes during their freeze-thaw process.\n OUTPUT:\n " }, { "from": "agent", "value": "The Migration Pattern of Atrazine during the Processes of Water Freezing and Thawing." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Monitoring of water quality is one of the world's main intentions for countries. Classification techniques based on support vector machines (SVMs) and artificial neural network (ANN) has been widely used in several applications of water research. Water quality assessment with high accuracy and efficiency with innovational approaches permitted us to acquire additional knowledge and information to obtain an intelligent monitoring system. In this paper, we present the use of principal component analysis (PCA) combined with SVM and ANN with decision templates combination data fusion method. PCA was used for features selection from original database. The multi-layer perceptron network (MLP) and the one-against-all strategy for SVM method have been widely used. Decision templates are applied to increase the accuracy of the water quality classification. The specific classification approach was employed to assess the water quality of the Tilesdit dam in Algeria as a study area, defined with a dataset of eight physicochemical parameters collected in the period 2009-2018, such as temperature, pH, electrical conductivity, and turbidity. The selection of the excellent parameters of the used models can be improving the performance of classification process. In order to assess their results, an experiment step using collected dataset corresponding to the accuracy and running time of training and test phases, and robustness to noise, is carried out. Various scenarios are examined in comparative study to obtain the most results of decision step with and without feature selection of the input data. From the results, we found that the integration of SVM and ANN with PCA yields accuracy up than 98%. The combination by decision templates of two classifiers SVM and ANN with PCA yields an accuracy of 99.24% using k-fold cross-validation. The combination data fusion enhanced expressively the results of the proposed monitoring framework that had proven a considerable ability in surface water quality assessment.\n OUTPUT:\n " }, { "from": "agent", "value": "A decision fusion method based on classification models for water quality monitoring." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Neddylation, or the covalent addition of NEDD8 to specific lysine residue of proteins, is a reversible posttranslational modification, which regulates numerous biological functions; however, its involvement and therapeutic significance in osteoporosis remains unknown. Our results revealed that during the soluble receptor activator of nuclear factor-κB ligand (sRANKL)-stimulated osteoclast differentiation, the neddylation and expression of UBA3, the NEDD8-activating enzyme (NAE) catalytic subunit, were dose- and time-dependently upregulated in RAW 264.7 macrophages. UBA3 knockdown for diminishing NAE activity or administering low doses of the NAE inhibitor MLN4924 significantly suppressed sRANKL-stimulated osteoclast differentiation and bone-resorbing activity in the macrophages by inhibiting sRANKL-stimulated neddylation and tumor necrosis factor receptor-associated factor 6 (TRAF6)-activated transforming growth factor-β-activated kinase 1 (TAK1) downstream signaling for diminishing nuclear factor-activated T cells c1 (NFATc1) expression. sRANKL enhanced the interaction of TRAF6 with the neddylated proteins and the polyubiquitination of TRAF6's lysine 63, which activated TAK1 downstream signaling; however, this process was inhibited by MLN4924. MLN4924 significantly reduced osteoporosis in an ovariectomy- and sRANKL-induced osteoporosis mouse model in vivo. Our novel finding was that NAE-mediated neddylation participates in RANKL-activated TRAF6-TAK1-NFATc1 signaling during osteoclast differentiation and osteoporosis, suggesting that neddylation may be a new target for treating osteoporosis.\n OUTPUT:\n " }, { "from": "agent", "value": "Inhibition of Neddylation Suppresses Osteoclast Differentiation and Function In Vitro and Alleviates Osteoporosis In Vivo." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: So far, shreds of evidence have shown that COVID-19 related hospitalization, serious outcomes, and mortality were high among individuals with chronic medical conditions. However, strict compliance with basic public health measures such as hand washing with soap, social distancing, and wearing masks has been recommended and proven effective in preventing transmission of the infection. Therefore, this study aimed to determine the level of compliance with COVID-19 preventive measures and identify its predictors among patients with common chronic diseases in public hospitals of Southern Ethiopia by applying the proportional odds model.\n OUTPUT:\n " }, { "from": "agent", "value": "Compliance with COVID-19 preventive measures among chronic disease patients in Wolaita and Dawuro zones, Southern Ethiopia: A proportional odds model." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Multiple temporary abdominal closure (TAC) techniques are currently used to manage the open abdomen (OA) in severely injured trauma patients, with variability in efficacy and cost. We evaluated the clinical outcomes of two commonly used TAC methods: ABTHERA Negative Pressure Therapy System and whipstitch suture closure (WC).\n OUTPUT:\n " }, { "from": "agent", "value": "Simple suture whipstitch closure is a reasonable option for many patients requiring temporary abdominal closure for blunt or penetrating trauma." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Pregnant people living with HIV (PLWH) are at especially high risk for progression from latent tuberculosis infection (LTBI) to active tuberculosis (TB) disease. Among pregnant PLWH, concurrent TB increases the risk of complications such as preeclampsia, intrauterine fetal-growth restriction, low birth weight, preterm-delivery, perinatal transmission of HIV, and admission to the neonatal intensive care unit. The grave impact of superimposed TB disease on maternal morbidity and mortality among PLWH necessitates clear guidelines for concomitant therapy and an understanding of the pharmacokinetics (PK) and potential drug-drug interactions (DDIs) between antitubercular (anti-TB) agents and antiretroviral therapy (ART) in pregnancy.\n OUTPUT:\n " }, { "from": "agent", "value": "Evidence for Implementation: Management of TB in HIV and Pregnancy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Microbial biotechnology uses microorganisms and their derivatives to generate industrial and/or environmental products that impact daily life. Modern biotechnology uses proteomics, metabolomics, quantum processors, and massive sequencing methods to yield promising results with microorganisms. However, the fundamental concepts of microbial biotechnology focus on the specific search for microorganisms from natural sources and their correct analysis to implement large-scale processes. This mini-review focuses on the methods used for the isolation and selection of microorganisms with biotechnological potential to empathize the importance of these concepts in microbial biotechnology. In this work, a review of the state of the art in recent years on the selection and characterization of microorganisms with a basic approach to understanding the importance of fundamental concepts in the field of biotechnology was carried out. The proper selection of isolation sources and the design of suitable selection criteria according to the desired activity have generated substantial changes in the development of biotechnology for more than three decades. Some examples include Taq polymerase in the PCR method and CRISPR technology. The objective of this mini review is to establish general ideas for the screening of microorganisms based on basic concepts of biotechnology that are left aside in several articles and maintain the importance of the basic concepts that this implies in the development of modern biotechnology.\n OUTPUT:\n " }, { "from": "agent", "value": "Fundaments and Concepts on Screening of Microorganisms for Biotechnological Applications. Mini Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Despite relational continuity (RC) with the doctor being key to care quality for chronic patients, particularly in fragmented healthcare systems, like many in Latin America (LA), little is known about RC and its attributes, particularly regarding specialists. Aim: We aim to analyse chronic patients' perceptions of RC with primary (PC) and secondary (SC) care doctors, and record changes between 2015 and 2017 in the public healthcare networks of six LA countries. An analysis of two cross-sectional studies applying the CCAENA questionnaire to chronic patients (N = 4881) was conducted in Argentina, Brazil, Chile, Colombia, Mexico, and Uruguay. The dependent variables of RC with PC and SC doctors were: consistency, trust, effective communication, and synthetic indexes based on RC attributes. Descriptive and multivariate analyses were performed. Although the RC index was high in 2015, especially in PC in all countries, and at both levels in Argentina and Uruguay, low perceived consistency of PC and SC doctors in Colombia and Chile and of SC doctors in Mexico revealed important areas for improvement. In 2017 the RC index of SC doctors increased in Chile and Mexico, while SC doctors' consistency in Colombia decreased. This study reveals important gaps in achieving RC with doctors, particularly in SC, which requires further structural and organisational reforms.\n OUTPUT:\n " }, { "from": "agent", "value": "Relational Continuity of Chronic Patients with Primary and Secondary Care Doctors: A Study of Public Healthcare Networks of Six Latin American Countries." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: We propose a spatial calibration method for wide field-of-view (FoV) near-eye displays (NEDs) with complex image distortions. Image distortions in NEDs can destroy the reality of the virtual object and cause sickness. To achieve distortion-free images in NEDs, it is necessary to establish a pixel-by-pixel correspondence between the viewpoint and the displayed image. Designing compact and wide-FoV NEDs requires complex optical designs. In such designs, the displayed images are subject to gaze-contingent, non-linear geometric distortions, which explicit geometric models can be difficult to represent or computationally intensive to optimize. To solve these problems, we propose neural distortion field (NDF), a fully-connected deep neural network that implicitly represents display surfaces complexly distorted in spaces. NDF takes spatial position and gaze direction as input and outputs the display pixel coordinate and its intensity as perceived in the input gaze direction. We synthesize the distortion map from a novel viewpoint by querying points on the ray from the viewpoint and computing a weighted sum to project output display coordinates into an image. Experiments showed that NDF calibrates an augmented reality NED with 90° FoV with about 3.23 pixel (5.8 arcmin) median error using only 8 training viewpoints. Additionally, we confirmed that NDF calibrates more accurately than the non-linear polynomial fitting, especially around the center of the FoV.\n OUTPUT:\n " }, { "from": "agent", "value": "Neural distortion fields for spatial calibration of wide field-of-view near-eye displays." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In China, the promotion of sexuality education for children and adolescents is hindered by a relatively conservative culture and insufficient drive from the government. With the government and the market failing to deliver in this area, social organizations, such as the third sector, are playing an important role. This paper mainly discusses how Chinese social organizations promote sexuality education for children and adolescents on a large scale. This paper studied NW, the largest sexuality education support platform in China at present, and 16 frontline implementing organizations in its cooperation network. This research collects empirical data through participatory observation and semi-structured interviews, involving a total of 37 interviewees, plus relevant text data. The study follows the analytical method of process tracking, trying to extract the key mechanisms of how social organizations promote sexuality education from the processes demonstrated by the specific cases. This paper focuses on the key phases of a standardized sexuality education program, from its design to promotion and then to implementation. It is found that, based on the large-scale operation strategy, the operation process of the sexuality education program exhibited three core mechanisms: standardized program design, organizational cooperation network and administrative mobilization. These three mechanisms have become the key force to break through many of the cultural and institutional obstacles and achieve large-scale implementation of sexuality education. Finally, this paper discusses the challenges of operationalizing the sexuality education program, with compromised teaching quality as a major one, and points to the direction for future research.\n OUTPUT:\n " }, { "from": "agent", "value": "Promoting Sexuality Education for Children and Adolescents on a Large Scale: Program Design, Organizational Cooperation Network and Administrative Mobilization." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Many prediction models for coronavirus disease 2019 (COVID-19) have been developed. External validation is mandatory before implementation in the intensive care unit (ICU). We selected and validated prognostic models in the Euregio Intensive Care COVID (EICC) cohort.\n OUTPUT:\n " }, { "from": "agent", "value": "Predicting COVID-19 prognosis in the ICU remained challenging: external validation in a multinational regional cohort." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Reversibility of frailty in the elderly has been discussed comprehensively and but association between recovery of frail state and rest-activity rhythm (RAR) patterns remains unclear. The aim of the current study was to examine a predictor of RAR patterns at the baseline against change of frail state after the intervention in the elderly community-dwellers. This study was performed during Covid-19 pandemic, at the period from April in 2020 to March in 2022. Participants were publicly recruited from senior's exercise program hosted by Akita city or Yurihonjo city. The revised Japanese version of the Cardiovascular Health Study criteria (revised J-CHS criteria) was used to assess frail state in each participant before and after the 6-month intervention. To measure the nonparametric RAR parameters consisting of interdaily stability (IS), intra-daily variability (IV), relative amplitude (RA) and average physical activity for the most active 10-h span (M10) or for the least active 5-h span (L5) over the average 24-h profile, an Actiwatch Spectrum Plus device was worn on each participant's non-dominant wrist for seven continuous days. The final samples were 75 participants except for persons with uncompleted data, classified into the improved group (n = 12), the maintained group (n = 53) and the deteriorated group (n = 10) according to frail alteration after the six-month intervention. As a result of the multinomial logistic regression analysis with the reference of the maintained group, the improvement of frail state associated with a low value of IS and total night-sleep time at the baseline, and M10 and L5 at the initial time were also able to predict worsening of frail state after the six-months intervention. A result of this follow-up study provides grounds for our proposal that alterations of RAR patterns in the elderly could be observed in association with recovery or worsening of frail state after the intervention. The potential finding, however, warrants further longitudinal investigation.\n OUTPUT:\n " }, { "from": "agent", "value": "Association between recovery of frailty state and the nonparametric rest-activity rhythm patterns in the elderly community-dwellers: A 6-month follow-up study during Covid-19 pandemic." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The concept of standardized nursing languages (SNLs) was introduced to solve the problem created by the use of different terminologies to document care by nurses working in diversified contexts. This study explored professional nurses' experiences in the utilization of SNL in documenting patients' care.\n OUTPUT:\n " }, { "from": "agent", "value": "Nurses' lived experiences in the utilization of standardized nursing languages in documentation of nursing care, in Cross River State, Nigeria." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: We present the measurement of entanglement between twin beams generated with a doubly resonant optical parameter oscillator (OPO) based on four-wave mixing in hot ^{85}Rb vapor above threshold. This is the first measurement of entanglement in an OPO with a χ^{(3)} media above threshold. We reconstruct the covariance matrix for several configurations and based on a full picture of the four side band mode state, we study entanglement between all possible bipartitions. We show a robust generation of entanglement with stronger generation for a specific pair of modes. For this system, we show that atomic density is a determinant factor for the generation and loss of quantum correlations. The generation of entangled fields with an atomic OPO operating close to atomic resonance of alkali atoms enables a natural integration into quantum networks.\n OUTPUT:\n " }, { "from": "agent", "value": "Continuous Variable Entanglement in an Optical Parametric Oscillator Based on a Nondegenerate Four Wave Mixing Process in Hot Alkali Atoms." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To investigate the effect of force applied during massage on relieving nonspecific low back pain (LBP).\n OUTPUT:\n " }, { "from": "agent", "value": "The Effect of Massage Force on Relieving Nonspecific Low Back Pain: A Randomized Controlled Trial." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The purpose of this work was to construct shallow neural networks (SNN) using time-lapse technology (TLT) from morphokinetic parameters coupled to assisted reproductive technology (ART) parameters in order to assist the choice of embryo(s) to be transferred with the highest probability of achieving a live birth (LB).\n OUTPUT:\n " }, { "from": "agent", "value": "Shallow artificial networks with morphokinetic time-lapse parameters coupled to ART data allow to predict live birth." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Liver cirrhosis (LC) takes the main place in the structure of the pathology of the digestive system in terms of the frequency of mortality, as well as in the development of fatal and poorly controlled complications, which requires the search for effective methods for preventing the progression of the disease and the development of complications. The article provides updated information on the role of the intestinal microbiota, as well as endotoxemia and increased intestinal permeability syndromes in the pathophysiology of LC and its complications. The results of recent meta-analyses of the impact of dysbiotic disorders on the prognosis of the LC and the options for their correction are presented. Understanding of the significance of involvement of gut microbiota in the pathogenesis of LC has become one of the levers of management of the risks of complications of LC. In this case, the livergut axis can be considered to be the leading link to the formation of most of the main complications of LC.\n OUTPUT:\n " }, { "from": "agent", "value": "[Liver cirrosis and complication risk management]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Little is known about how many patients with hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) receive on-demand and/or prophylactic treatment and what their clinical features are. Here, we estimated, using Delphi-based consensus, prevalence and treatment patterns in Germany as well as patient features linked to long-term prophylaxis.\n OUTPUT:\n " }, { "from": "agent", "value": "Patients with hereditary angioedema and their treatment patterns in Germany: a Delphi consensus study" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The anatomical elements that in humans prevent blood backflow from the aorta and pulmonary artery to the left and right ventriclesare the aortic and pulmonary valves, respectively. Each valve regularly consists of three leaflets (cusps), each supported by its valvular sinus. From the medical viewpoint, each set of three leaflets and sinuses is regarded as a morpho-functional unit. This notion also applies to birds and non-human mammals. However, the structures that prevent the return of blood to the heart in other vertebrates are notably different. This has led to discrepancies between physicians and zoologists in defining what a cardiac outflow tract valve is. The aim here is to compare the gross anatomy of the outflow tract valvular system among several groups of vertebrates in order to understand the conceptual and nomenclature controversies in the field.\n OUTPUT:\n " }, { "from": "agent", "value": "The Medical versus Zoological Concept of Outflow Tract Valves of the Vertebrate Heart." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In recent years, the harmonization of domestic and foreign clinical recommendations for the treatment of cystitis has been achieved. Nitrofurans and fosfomycin trometamol are recommended as first line therapy antibiotics, and oral 3rd generation of cephalosporins are recommended as alternative antibiotics; fluoroquinolones are excluded from the recommended medications due to an unfavorable safety profile. The main rationale for inclusion of antibiotics in the recommendations as a first line therapy of cystitis is the level of resistance of uropathogens to antibiotics, primarily Escherichia coli. Stable low level of resistance of E. coli in Russia was noted to nitrofurans and fosfomycin (5%), higher to cephalosporins. Among nitrofurans, furazidine is characterized by higher activity against E. coli compared to nitrofurantoin. The potassium salt of furazidine in dosage form with magnesium carbonate is preferred, since it is characterized by higher bioavailability and provides a therapeutic level of concentrations in urine above the MIC during the entire dosing period. Due to the global increase in the resistance of uropathogens observed in recent years, experts have begun to pay more and more attention to the ecological safety of antimicrobial therapy in order to minimize the risk of concomitant (collateral) damage, contributing to the selection of multi-drug resistant strains of microorganisms. In the latest WHO document of 2021, experts divided antibiotics into three groups (ACCESS, WATCH, RESERVE) according to the priority of choice. The ACCESS group of drugs for the treatment of cystitis includes nitrofurantoin and furazidine as agents with minimal collateral effect, while fosfomycin trometamol and cephalosporins are listed in the WATCH group. Thus, from the standpoint of ecological safety, WHO experts recommend prescribing nitrofurans in the treatment of cystitis in the first line of therapy.\n OUTPUT:\n " }, { "from": "agent", "value": "[Rationale for choosing an antibiotic for the treatment of cystitis: recommendations of clinical pharmacologists: A review]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Dilated cardiomyopathy (DCM) is a common cause of heart failure (HF) and is of familial origin in 20-40% of cases. Genetic testing by next-generation sequencing (NGS) has yielded a definite diagnosis in many cases; however, some remain elusive. In this study, we used a combination of NGS, human-induced pluripotent-stem-cell-derived cardiomyocytes (iPSC-CMs) and nanopore long-read sequencing to identify the causal variant in a multi-generational pedigree of DCM. A four-generation family with familial DCM was investigated. Next-generation sequencing (NGS) was performed on 22 family members. Skin biopsies from two affected family members were used to generate iPSCs, which were then differentiated into iPSC-CMs. Short-read RNA sequencing was used for the evaluation of the target gene expression, and long-read RNA nanopore sequencing was used to evaluate the relevance of the splice variants. The pedigree suggested a highly penetrant, autosomal dominant mode of inheritance. The phenotype of the family was suggestive of laminopathy, but previous genetic testing using both Sanger and panel sequencing only yielded conflicting evidence for \n OUTPUT:\n " }, { "from": "agent", "value": "Genotype Complements the Phenotype: Identification of the Pathogenicity of an LMNA Splice Variant by Nanopore Long-Read Sequencing in a Large DCM Family." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The state of digitalisation in the healthcare sector in Switzerland is lagging, even as the national electronic health record (EHR) is being gradually implemented. Little is known about the implementation of electronic prescribing systems, their auxiliary features or drug datasets in Swiss hospitals.The aim of this study was to understand which electronic systems are implemented to support doctors in Swiss hospitals during the medication prescribing process.\n OUTPUT:\n " }, { "from": "agent", "value": "Digitalisation of the drug prescribing process in Swiss hospitals - results of a survey." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Diabetes is a metabolic pathology with chronic high blood glucose levels that occurs when the pancreas does not produce enough insulin or the body does not properly use the insulin it produces. Diabetes management is a puzzle and focuses on a healthy lifestyle, physical exercise, and medication. Thus far, the condition remains incurable; management just helps to control it. Its medical treatment is expensive and is to be followed for the long term, which is why people, especially from low-income countries, resort to herbal medicines. However, many active compounds isolated from plants (phytocompounds) are poorly bioavailable due to their low solubility, low permeability, or rapid elimination. To overcome these impediments and to alleviate the cost burden on disadvantaged populations, plant nanomedicines are being studied. Nanoparticulate formulations containing antidiabetic plant extracts or phytocompounds have shown promising results. We herein aimed to provide an overview of the use of lipid- and inorganic-based nanoparticulate delivery systems with plant extracts or phytocompounds for the treatment of diabetes while highlighting their advantages and limitations for clinical application. The findings from the reviewed works showed that these nanoparticulate formulations resulted in high antidiabetic activity at low doses compared to the corresponding plant extracts or phytocompounds alone. Moreover, it was shown that nanoparticulate systems address the poor bioavailability of herbal medicines, but the lack of enough preclinical and clinical pharmacokinetic and/or pharmacodynamic trials still delays their use in diabetic patients.\n OUTPUT:\n " }, { "from": "agent", "value": "An Overview of Herbal-Based Antidiabetic Drug Delivery Systems: Focus on Lipid- and Inorganic-Based Nanoformulations." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cancer cachexia is a fatal syndrome associated with muscle regeneration disability. Tumor factors induce the apoptosis of myoblasts to impair the regeneration of skeletal muscle. Cancer cachectic myoblast apoptosis is associated with mitochondria injury. It has been reported that activated mitochondrial calpain caused mitochondria injury in mouse cardiomyocytes and pulmonary smooth muscle. We wondered if mitochondrial calpains exist in skeletal myoblast and their potential role in myoblast apoptosis of cancer cachexia. We used a transwell to build a novel myoblast-carcinoma cell coculture model to simulate the cancer cachexia environment in vitro. Calpain inhibitors, calpastatin (CAST) and calpeptin (CAPT), were used during coculture. We found for the first time that two calpains (calpain-1 and calpain-2) and CAST were present in the mitochondria of myoblast. The activation of mitochondrial calpain decreased mitochondrial complex I activity, promoted mitochondrial permeability transition pore opening, and impaired mitochondrial membrane potential in myoblast during coculture, which induced myoblasts apoptosis. CAST and CAPT protected myoblasts from apoptosis by inhibiting mitochondrial calpain activity, which may attenuate or even reverse cancer cachectic muscle atrophy by improving muscle regeneration ability. Our study provides a new perspective for understanding the mechanism of cancer cachexia, and will further contribute to treat cancer cachexia by focusing on the mitochondrial calpain activity.\n OUTPUT:\n " }, { "from": "agent", "value": "Calpain inhibitors inhibit mitochondrial calpain activity to ameliorate apoptosis of cocultured myoblast." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: (1) Background: HIV-1 sub-subtype A1 is common in parts of Africa, Russia, former Soviet Union countries, and Eastern Europe. In Pakistan, sub-subtype A1 is the predominant HIV-1 subtype. Preliminary evidence suggests that distinct strains of HIV-1 sub-subtype A1 are circulating in Pakistan; however, an in-depth molecular phylogenetic characterization of HIV-1 sub-subtype A1 strains in Pakistan have not been presented. We performed a detailed characterization of the HIV-1 sub-subtype A1 epidemic in Pakistan using state-of-the-art molecular epidemiology and phylodynamics. (2) Methods: A total of 143 HIV-1 sub-subtype A1 \n OUTPUT:\n " }, { "from": "agent", "value": "Phylogenetic Characterization of HIV-1 Sub-Subtype A1 in Karachi, Pakistan." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Preclinical studies have shown that parathyroid hormone (PTH) loses its biological effects through oxidation. PTH can be oxidized at methionines 8 and 18. Three possible variations of oxidized PTH (oxPTH) exist: Met8(ox)PTH, Met18(ox)PTH, and Met8, Met18(di-ox)PTH. A recent study showed that Met18(ox)PTH retained biological activity and was able to upregulate \n OUTPUT:\n " }, { "from": "agent", "value": "Biological Activity of Different Forms of Oxidized Parathyroid Hormone." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Silent speech interfaces (SSIs) enable speech recognition and synthesis in the absence of an acoustic signal. Yet, the archetypal SSI fails to convey the expressive attributes of prosody such as pitch and loudness, leading to lexical ambiguities. The aim of this study was to determine the efficacy of using surface electromyography (sEMG) as an approach for predicting continuous acoustic estimates of prosody. Ten participants performed a series of vocal tasks including sustained vowels, phrases, and monologues while acoustic data was recorded simultaneously with sEMG activity from muscles of the face and neck. A battery of time-, frequency-, and cepstral-domain features extracted from the sEMG signals were used to train deep regression neural networks to predict fundamental frequency and intensity contours from the acoustic signals. We achieved an average accuracy of 0.01 ST and precision of 0.56 ST for the estimation of fundamental frequency, and an average accuracy of 0.21 dB SPL and precision of 3.25 dB SPL for the estimation of intensity. This work highlights the importance of using sEMG as an alternative means of detecting prosody and shows promise for improving SSIs in future development.\n OUTPUT:\n " }, { "from": "agent", "value": "Prediction of Voice Fundamental Frequency and Intensity from Surface Electromyographic Signals of the Face and Neck." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cancer is frequently associated with the appearance of cachexia, a multifactorial wasting syndrome. Cachexia develops either as a result of tumor progression or as a side effect of anticancer treatments, especially of standard chemotherapy, eventually representing the direct cause of death in up to one third of all cancer patients. Cachexia, within its multi-organ affection, is characterized by severe loss of muscle mass and function, representing the most relevant subject of preclinical and clinical investigation.\n OUTPUT:\n " }, { "from": "agent", "value": "Targeting mitochondria and oxidative stress in cancer- and chemotherapy-induced muscle wasting." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: BACKGROUND Leiomyosarcoma (LMS) of the inferior vena cava (IVC) is a rare malignancy, and complete resection may provide better patient survival. Hepatectomy for intrahepatic tumor recurrence has not been previously reported. CASE REPORT A 58-year-old woman underwent resection of an IVC-LMS with en bloc nephrectomy, adrenalectomy, and retroperitoneal soft tissue resection without IVC reconstruction 3 years 8 months ago. Twenty-nine months after the primary operation, a solitary intrahepatic liver tumor was found adjacent to the right and middle hepatic veins during imaging follow-up. The patient was diagnosed with LMS recurrence. As her liver functional parameters permitted major hepatectomy, right hepatectomy combined with resection of the vena cava wall leaving a tumor-free margin and securing the confluence of the middle hepatic vein were successfully accomplished via an anterior approach, without adverse events. Intrahepatic metastasis of LMS invading the vena cava wall has been diagnosed historically. Her postoperative course was uneventful, and at 1-year follow-up after the second surgery, she was observed to have no tumor relapse without any adjuvant treatment. Previous reports have shown that IVC-LMS is often observed, and operative risk or prognosis is based on the extension of the LMS toward the hepatic veins or cardiac atrium. CONCLUSIONS Radical hepatectomy for recurrent IVC-LMS has not been previously reported, and our case experience revealed that a challenging surgical intervention resulting in complete tumor removal can provide good survival outcomes.\n OUTPUT:\n " }, { "from": "agent", "value": "Successful Right Hepatectomy for Recurrent Liver Tumor Originating from an Inferior Vena Cava Leiomyosarcoma: A Follow-Up Case Report." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cancer cells need a steady supply of nutrients to evade cell death and proliferate. Depriving cancer cells of the amino acid cystine can trigger the non-apoptotic cell death process of ferroptosis. Here, we report that cancer cells can evade cystine deprivation-induced ferroptosis by uptake and catabolism of the cysteine-rich extracellular protein albumin. This protective mechanism is enhanced by mTORC1 inhibition and involves albumin degradation in the lysosome, predominantly by cathepsin B (CTSB). CTSB-dependent albumin breakdown followed by export of cystine from the lysosome via the transporter cystinosin fuels the synthesis of glutathione, which suppresses lethal lipid peroxidation. When cancer cells are grown under non-adherent conditions as spheroids, mTORC1 pathway activity is reduced, and albumin supplementation alone affords considerable protection against ferroptosis. These results identify the catabolism of extracellular protein within the lysosome as a mechanism that can inhibit ferroptosis in cancer cells.\n OUTPUT:\n " }, { "from": "agent", "value": "Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Given that human \n OUTPUT:\n " }, { "from": "agent", "value": "Less Pronounced Immunopathological Responses Following Oral Butyrate Treatment of " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Ehlers-Danlos syndromes (EDS) are a group of disorders characterized by abnormal connective tissue affecting several organ systems. Patients with the hypermobile type of EDS (hEDS) commonly experience chronic pain which can present as musculoskeletal pain, fibromyalgia, neuropathic pain or abdominal pain. The effective management of chronic pain in hEDS patients is a challenge. This study reviews two cases of chronic pain in hEDS patients and the multimodal treatment regimen used along with peripheral nerve stimulation for shoulder and knee pains, never before reported in hEDS patients. Since hEDS associated chronic pain is multifactorial in origin, treatment requires a multidisciplinary approach which includes physical therapy, psychotherapy, pharmacotherapy and interventional pain procedures such as trigger point injections, peripheral nerve block, radiofrequency ablation and peripheral nerve stimulation.\n OUTPUT:\n " }, { "from": "agent", "value": "Multidisciplinary chronic pain management strategies in patients with Ehlers-Danlos syndromes." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Recent research has contested the previously accepted paradigm that volatile anaesthetics improve outcomes in cardiac surgery patients when compared to intravenous anaesthesia. In this review we summarise the mechanisms of myocardial ischaemia/reperfusion injury and cardioprotection in cardiac surgery. In addition, we make a comprehensive analysis of evidence comparing outcomes in patients undergoing cardiac surgery under volatile or intravenous anaesthesia, in terms of mortality and morbidity (cardiac, neurological, renal, pulmonary).\n OUTPUT:\n " }, { "from": "agent", "value": "Volatile Anaesthesia versus Total Intravenous Anaesthesia for Cardiac Surgery-A Narrative Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Inflammation is generally thought to be involved in the occurrence and development of preeclampsia (PE), but its specific effect on PE remains unclear. In the present study, the expression levels of 92 inflammation-related proteins were measured in the late pregnancy maternal plasma from patients with PE (\n OUTPUT:\n " }, { "from": "agent", "value": "Plasma Olink Proteomics Identifies CCL20 as a Novel Predictive and Diagnostic Inflammatory Marker for Preeclampsia." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Two >130-meter-diameter impact craters formed on Mars during the later half of 2021. These are the two largest fresh impact craters discovered by the Mars Reconnaissance Orbiter since operations started 16 years ago. The impacts created two of the largest seismic events (magnitudes greater than 4) recorded by InSight during its 3-year mission. The combination of orbital imagery and seismic ground motion enables the investigation of subsurface and atmospheric energy partitioning of the impact process on a planet with a thin atmosphere and the first direct test of martian deep-interior seismic models with known event distances. The impact at 35°N excavated blocks of water ice, which is the lowest latitude at which ice has been directly observed on Mars.\n OUTPUT:\n " }, { "from": "agent", "value": "Largest recent impact craters on Mars: Orbital imaging and surface seismic co-investigation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The COVID-19 pandemic is a global mental health crisis that disproportionately impacts adolescents. Loneliness is a particularly salient pandemic psychosocial outcome to understand; however, research to date on this outcome is sparse and largely cross-sectional. In response, we examined pre-pandemic risk factors for pandemic loneliness. Further, we examined how risk may differ based on key demographics, and whether mediation or moderation models best explained potential disparities in experiencing loneliness. Self-reported, pre-pandemic mental health, trauma exposure, and family conflict survey data were collected at Wave 1 in a diverse sample of 369 adolescents (54.5% female, 45.5% male; 30.1% White; 30.9% Black; 18.4% Hispanic; M\n OUTPUT:\n " }, { "from": "agent", "value": "Adolescent Loneliness during the COVID-19 Pandemic: The Role of Pre-Pandemic Risk Factors." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Left bundle branch pacing (LBBP) has emerged as an alternative to biventricular pacing (BVP) for delivering cardiac resynchronization therapy. We sought to compare the acute improvement of electrical and mechanical synchrony, and hemodynamics between LBBP and BVP in patients with heart failure and left bundle branch block.\n OUTPUT:\n " }, { "from": "agent", "value": "Left Bundle Branch Pacing Versus Biventricular Pacing for Acute Cardiac Resynchronization in Patients With Heart Failure." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To evaluate admission Animal Trauma Triage (ATT) score, shock index (SI), and markers of perfusion, including base excess (BE), plasma lactate, and lactate clearance in dogs with blunt trauma.\n OUTPUT:\n " }, { "from": "agent", "value": "Markers of tissue perfusion and their relation to mortality in dogs with blunt trauma." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Individuals affected by COVID-19 have an alteration in autonomic balance, associated with impaired cardiac parasympathetic modulation and, consequently, a decrease in heart rate variability (HRV). This study examines the inter- and intrarater reliability of HRV) parameters derived from short-term recordings in individuals post-COVID. Sixty-nine participants of both genders post-COVID were included. The RR interval, the time elapsed between two successive R-waves of the QRS signal on the electrocardiogram (RRi), were recorded during a 10 min period in a supine position using a portable heart rate monitor (Polar\n OUTPUT:\n " }, { "from": "agent", "value": "Intra- and Interrater Reliability of Short-Term Measurement of Heart Rate Variability on Rest in Individuals Post-COVID-19." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The Japanese quail (\n OUTPUT:\n " }, { "from": "agent", "value": "Impacts of Continuous and Intermittent Use of Bovine Colostrum on Laying Japanese Quails: Egg Performance and Traits, Blood Biochemical and Antioxidant Status." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Scoliosis is a degenerative disease with a 3D deformity in the alignment of the spinal column. Surgical spinal correction outcomes are heavily dependent on the surgeon's expertise and use of visual cues because of time requirements, lack of automation, and radiation exposure associated with current intraoperative measurement techniques. In this study, the authors sought to validate a novel, nonradiographic, and semiautomated device that measures spinal alignment intraoperatively using deep learning and computer vision.\n OUTPUT:\n " }, { "from": "agent", "value": "Semiautomated intraoperative measurement of Cobb angle and coronal C7 plumb line using deep learning and computer vision for scoliosis correction: a feasibility study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: One of the main challenges in wound healing is the wound infection due to various causes, of which moisture is the most important reason. Owing to this fact, wound dressings that can collect wound moisture in addition to showing antibacterial properties have provided an important basis for wound healing research. In this study, gelatin and poly lactic acid (PLA) polymers were used in a wound dressing textile to provide gelation and structure strength properties, respectively. Meanwhile, silver nanoparticles (SNPs) synthesized through the green method were integrated into these fibers to provide the formed textile with antibacterial properties. Nanoparticles were made using donkey dung extract, and nanofibers were produced by the solution blow spinning method which has high production efficiency and low energy consumption among spinning methods. The produced nanoparticles were characterized and evaluated by UV-Vis, DLS, XRD, and FTIR methods, and the production of silver nanoparticles that were coated with metabolites in the extract was proven. In addition, the morphology and diameter of the resulted fibers and presence of nanoparticles were confirmed by the SEM method. The size and size distribution of the synthesized fibers were determined through analyzing SEM results. Gelatin nanofibers demonstrated a mean size of 743 nm before and 773 nm after nanoparticle coating. PLA nanofibers demonstrated a mean size of 57 nm before and 182 nm after nanoparticle coating. Finally, 335 nm was the mean diameter size of gelatin/PLA/SNPs nanofibers. Also, the textiles synthesized by PLA and gelatin which contained silver nanoparticles showed higher antibacterial activity against both gram-positive and gram-negative species compared to PLA and gelatin tissues without nanoparticles. Cytotoxicity test on L929 cells showed that silver nanoparticles incorporated textiles of PLA and gelatin show a very low level and non-significant toxicity compared to the free particles.\n OUTPUT:\n " }, { "from": "agent", "value": "Antimicrobial Activity of Blow Spun PLA/Gelatin Nanofibers Containing Green Synthesized Silver Nanoparticles against Wound Infection-Causing Bacteria." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The prevalence of Amblyomma geoemydae infesting yellow-margined box turtle (Cuora flavomarginata) was determined for the first time in northern Taiwan. In total, 352 ticks (140 adults, 61 nymphs and 151 larvae) were collected from 56 yellow-margined box turtles. The overall infestation was observed with an average density of 6.3 ticks per turtle and the highest seasonal prevalence was observed on March with an average tick density of 14.3 ticks per turtle. The higher seasonal prevalence was observed on April, May, July and October with an average density of 4.8, 8.3, 5.7 and 8.5 ticks per turtle, respectively. The seasonal activity of these turtles may contribute to the variation in the number of collected ticks. The genetic identity was determined by comparing the sequences of ITS2 genes obtained from seven Taiwan species of A. geoemydae and nine other species representing eight Amblyomma species and Ixodes persulcatus as outgroup. Our results provide the first zootiological survey of A. geoemydae infesting wild turtles in northern Taiwan and highlight the importance of this tick species in the study of parasite dynamics on testudines in Taiwan. Further study focused on the seasonality pattern of turtle ticks will help reveal the ecology of this host-parasite system and its impact on animal/human health.\n OUTPUT:\n " }, { "from": "agent", "value": "First zootiological survey of Amblyomma geoemydae ticks (Acari: Ixodidae) infesting a wild turtle (Cuora flavomarginata) in northern Taiwan." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The purpose of this study was to determine the influence of mandibular unilateral and bilateral distal extension partial edentulous situation and the use of removable partial dental prostheses on the force exerted on maxillary anterior teeth. A commercially available jaw model with exchangeable teeth was used. Seven experimental conditions of mandibular distal extension edentulous situation were prepared and a distal extension removable partial dental prosthesis to replace missing posterior teeth was fabricated. The occlusal force was measured by inserting an occlusal force measuring film between the maxillary and mandibular teeth of the model. An occlusal load was applied and the forces and ratios were compared using the Kruskal-Wallis test and the Mann-Whitney U test (p < 0.05). As a result, the force exerted on the maxillary anterior teeth increased significantly as the number of remaining teeth decreased in unilateral and bilateral edentulous situation. The force exerted on the maxillary anterior teeth decreased significantly with use of a removable partial dental prosthesis. It is concluded that when the number of remaining teeth decreases in mandibular unilateral and bilateral distal extension partial edentulous situation, the burden on the maxillary anterior teeth increases. Our findings suggest that for patients with mandibular distal extension partial edentulous situation, using a removable partial dental prosthesis is effective in preserving the remaining teeth by reducing excessive force.\n OUTPUT:\n " }, { "from": "agent", "value": "Force exerted on maxillary anterior teeth in mandibular unilateral and bilateral distal extension partial edentulous situation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The use of virus-neutralizing monoclonal antibodies is an effective method of etiotropic therapy for SARS-CoV-2 in patients of high-risk groups of severe COVID-19. Regdanvimab is a single-component monoclonal antibodies immunoglobulin G1, whose mechanism of action is aimed at binding SARS-CoV-2 virus at the RBD site of the spike protein S1 domain. In the Russian Federation, regdanvimab is approved for emergency administration in COVID-19 for adult patients not requiring respiratory therapy who are at high risk of developing a severe course of the disease.\n OUTPUT:\n " }, { "from": "agent", "value": "[Efficacy and safety of regdanvimab in patients with mild/moderate COVID-19 and high risk of progression of the disease: a retrospective study in a short-term stay unit]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The purpose of this study was to evaluate the periodontal status of patients who routinely did SPT, when compared to patients that did not SPT. This retrospective cohort study was conducted at a general dental office from 2001 to 2019. Patients aged 18 to 81 years who visited the dental office over a 10-year period were assigned into two groups: an SPT group, which included patients who continually visited the dental office for SPT one or more times every year, and an irregular group, consisting of patients who did not visit the dental office at least once a year. A total of 7307 teeth (SPT group) and 4659 teeth (irregular group) were evaluated, and the periodontal conditions were compared between the first and latest visits. Multiple regression analysis was used to analyze the results. The mean follow-up time was 13.74 years. The risk factors for improvements in probing pocket depth included age, sex, smoking, diabetes mellitus, molar tooth, and irregular SPT group (p < 0.001), and that for a positive bleeding on probing site was the irregular group (odds ratio 2.94; 95% confidence interval 2.63-3.29). This study showed that lack of routine in attending the SPT program significantly decreased the periodontal parameters, thus highlighting the importance of continuing with the program to maintain the periodontal health.\n OUTPUT:\n " }, { "from": "agent", "value": "Differences in periodontal parameters between SPT patients who regularly and irregularly visited the dental clinic analyzed at tooth level: a 14-year retrospective cohort study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Neonate patients have a reduced thoracic cavity, making thoracoscopic procedures even more challenging than their adult counterparts.\n OUTPUT:\n " }, { "from": "agent", "value": "Design and validation of looping assistance methods in robotic-assisted neonatal surgical suturing in a chest model." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cardiac lipomas, especially ones originating from the left ventricle, are extremely rare. They may be asymptomatic or may present with various non-specific symptoms. Herein, we report a case of a giant lipoma of the left ventricle, with frequent ventricular premature beats on electrocardiogram. An echocardiogram demonstrated a large hyperechoic mass occupying a significant portion of the left ventricle. We further describe the diagnostic workup utilizing multimodality cardiac imaging and treatment options. Cardiac MRI demonstrated fat suppression, and cardiac CT showed a homogenous low-attenuation mass suggesting lipomatous matter. The mass was subsequently surgically removed for pathology examination in order to rule out liposarcoma. Histopathology demonstrated mature adipocytes, entrapped myocytes with hypertrophy, and interstitial fibrosis foci confirming the diagnosis of lipoma.\n OUTPUT:\n " }, { "from": "agent", "value": "Giant Intracardiac Lipoma: A Case Report and the Role of Multimodality Cardiac Imaging." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Progestin resistance is a major obstacle to conservative therapy in patients with endometrial cancer (EC) and endometrial atypical hyperplasia (EAH). However, the related inducing factor is yet unclear. In this study, thyroid hormone and its receptor α (TRα) and β (TRβ) of patients were assayed. THRB-silenced RL95-2 and KLE EC cells were cultured to investigate the response of progestins. Transcriptomics and Western blotting were performed to investigate the changes in signaling pathways. We found that THRB, rather than THRA, knockdown promoted the viability and motilities of RL95-2 cells but not KLE cells. The suppressive effect of progestins on cell growth and motility significantly decreased in THRB-silenced RL95-2 cells. Multiple proliferation-related signaling pathways were enriched, and the activities of mammalian targets of rapamycin (mTOR)/4e-binding protein 1 (4EBP1)/eukaryotic translation initiation factor 4G (eIF4G) rather than phosphorylated protein kinase B (Akt) were remarkably boosted. Progestin treatment enhanced the effects, and the augmentation was partially abated on supplementation with T3. In THRB-knockdown KLE cells, the progestins-activated partial signaling pathway expression (either mTOR or eIF4G), and supplementation with T3 did not induce noticeable alterations. The serum levels of triiodothyronine (T3) were significantly lower in patients with EC compared with healthy women. A strong expression of TRβ was observed in most patients with EC and EAH sensitive to progestin treatment. In contrast, TRα positive expression was detected in less than half of the patients sensitive to progestin therapy. In conclusion, THRB knockdown enhanced the viability and motility of type I EC cells and attenuated the suppressive effects of progestins by activating the mTOR-4EBP1/eIF4G pathway. Lower expression of THRB is likely correlated with progesterone resistance.\n OUTPUT:\n " }, { "from": "agent", "value": "Thyroid Hormone Receptor β Knockdown Reduces Suppression of Progestins by Activating the mTOR Pathway in Endometrial Cancer Cells." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ' fibrinogen (GPF), in 103 hospitalized patients with COVID-19 and 19 healthy controls. We found significant associations between GPF levels and the severity of COVID-19 as judged by blood oxygen saturation (SpO \n OUTPUT:\n " }, { "from": "agent", "value": "Gamma' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Diabetic neuropathy (DN) is a type of sensory nerve damage that can occur in patients with diabetes. Although the understanding of pathophysiology is incomplete, DN is often associated with structural and functional alterations of the affected neurons. Among all possible causes of nerve damage, Schwann cells (SCs) are thought to play a key role in repairing peripheral nerve injury, suggesting that functional deficits occurring in SCs may potentially exhibit their pathogenic roles in DN. Therefore, elucidating the mechanisms that underlie this pathology can be used to develop novel therapeutic targets. In this regard, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have recently attracted great attention in ameliorating SCs' dysfunction. However, the detailed mechanisms remain uncertain. In the present study, we investigated how GLP-1 RA Liraglutide protects against RSC96 SCs dysfunction through a diabetic condition mimicked by high glucose and high free fatty acid (FFA). Our results showed that high glucose and high FFAs reduced the viability of RSC96 SCs by up to 51%, whereas Liraglutide reduced oxidative stress by upregulating antioxidant enzymes, and thus protected cells from apoptosis. Liraglutide also inhibited NFκB-mediated inflammation, inducing SCs to switch from pro-inflammatory cytokine production to anti-inflammatory cytokine production. Moreover, Liraglutide upregulated the production of neurotrophic factors and myelination-related proteins, and these protective effects appear to be synergistically linked to insulin signaling. Taken together, our findings demonstrate that Liraglutide ameliorates diabetes-related SC dysfunction through the above-mentioned mechanisms, and suggest that modulating GLP-1 signaling in SCs may be a promising strategy against DN.\n OUTPUT:\n " }, { "from": "agent", "value": "Liraglutide Attenuates Glucolipotoxicity-Induced RSC96 Schwann Cells' Inflammation and Dysfunction." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Mini dental implants (MDIs) are an affordable alternative for overdentures in medically compromised patients with reduced bone volume. This human study reports the histomorphometric analysis of early loaded and flaplessly placed tapered, one-piece MDIs (ILZ, Southern Implants; Sa: 1.5 μm) after 7 to 11 months in function. Patients agreed to have an additional MDI placed and removed for evaluation. MDI stability was assessed via Periotest prior to implant removal. Histologic sections of four mandibular and three maxillary MDIs with surrounding bone were processed, and the bone-to-implant contact (BIC) was analyzed. At retrieval, the MDIs were in function for more than 6 months, were clinically healthy, and had mean probing pocket depths of 1.4 mm and 1.6 mm in the maxilla and mandible, respectively. Periotest values were < 5.5, indicating clinical stability. Most of the screw threads were filled with bone and revealed an intimate BIC, without any signs of intervening fibrous tissue layer. In both arches, the mean BIC was 68.5%. Large osteocytes could be identified in the calcified tissue, indicative of mature peri-implant bone. It can be concluded that MDIs, when loaded within 2 weeks in either arch, provide proper clinical stability and high BIC after 6 months.\n OUTPUT:\n " }, { "from": "agent", "value": "Histomorphometric Analysis of Flaplessly Placed and Early Loaded One-Piece Mini Dental Implants in Overdenture Patients." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: (1) Background: Significant advances in digital modelling worldwide have been attributed to the practical application of digital musculoskeletal (MS) models in clinical practice. However, the vast majority of MS models are designed to assess adults' mobility, and the range suitable for children is very limited. (2) Methods: Seventeen healthy and 4 cerebral palsy (CP) children were recruited for the gait measurements. Surface electromyography (EMG) and ground reaction forces (GRFs) were acquired simultaneously. The MS model of the adult was adapted to the child and simulated in AnyBody. The differences between measured and MS model-estimated GRFs and muscle activations were evaluated using the following methods: the root-mean-square error (RMSE); the Pearson coefficient \n OUTPUT:\n " }, { "from": "agent", "value": "Accuracy of Ground Reaction Force and Muscle Activation Prediction in a Child-Adapted Musculoskeletal Model." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The objective and relative competitiveness of obstetrical and gynecologic subspecialty training programs remain understudied. Traditional metrics, such as match rate or program fill rate, fail to standardize the application environment. This limits their applicability when examining demographic trends or when comparing data between different fellowship matches. The normalized competitive index was introduced to serve as a comprehensive metric of competitiveness by incorporating disparate indicators and normalizing to enable more detailed analyses.\n OUTPUT:\n " }, { "from": "agent", "value": "Analyzing trends in obstetrics and gynecology fellowship training over the last decade using the normalized competitive index." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Neuroendocrine neoplasms (NEN) originate from neuroendocrine cells ubiquitously spread throughout the body. Hypercalcemia associated with cancer is the most common life-threatening metabolic disorder in patients with advanced stage cancer. Paraneoplastic hypercalcemia is more commonly associated with hematological malignancies, renal and breast carcinomas, and squamous cell carcinomas, but it has also been described in patients with well-differentiated NEN, where it often remains undiagnosed. Among its causes, systemic secretion of parathyroid hormone-related protein (PTHrP) and ectopic production of 1,25-dihydroxyvitamin D and parathyroid hormone (PTH) may be considered paraneoplastic causes of hypercalcemia. In order to clarify the diagnostic work up of paraneoplastic hypercalcemia in patients with NEN, we perform a systematic review, which is lacking in the literature.\n OUTPUT:\n " }, { "from": "agent", "value": "What Lies behind Paraneoplastic Hypercalcemia Secondary to Well-Differentiated Neuroendocrine Neoplasms? A Systematic Review of the Literature." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Hydrogen produced from biomass feedstocks is considered an effective solution in moving toward a decarbonized economy. Biohydrogen is a clean energy source that has gained global attention for adoption as it promises to mitigate climate change and human environmental damage. Through the circular economy framework, sustainable biohydrogen production with other bioproducts while addressing issues such as waste management is possible. This study presents a comprehensive review of the various biomass feedstocks and processing technologies associated with biohydrogen generation, as well as the possible integration of existing industries into a circular bioeconomy framework. The currently standing challenges and future perspectives are also discussed.\n OUTPUT:\n " }, { "from": "agent", "value": "Biohydrogen in a circular bioeconomy: A critical review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To describe the clinical characteristics of secondary hemophagocytic lymphohistiocytosis (HLH) among adult patients, investigate its risk factors for 90-day overall survival (OS) from diagnosis, and establish a new prognostic model applicable to adult patients with secondary HLH.\n OUTPUT:\n " }, { "from": "agent", "value": "Clinical characteristics and risk factors for 90-day overall survival among 204 adult patients with secondary hemophagocytic lymphohistiocytosis: Experience from a single-center retrospective study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: [This corrects the article DOI: 10.2147/IJN.S21523.].\n OUTPUT:\n " }, { "from": "agent", "value": "Erratum: Targeted Delivery of Doxorubicin Utilizing Chitosan Nanoparticles Surface Functionalized with Anti Her2 Trastuzumab [Corrigendum]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Side-chain type sulfonated poly(phenylquinoxaline) (SPPQ)-based proton exchange membranes (PEMs) with different ionic exchange capacity (IEC) were successfully synthesized by copolymerization from 4,4'-bis (2-diphenyletherethylenedione) diphenyl ether, 4,4'-bis (2-phenylethylenedione) diphenyl ether and 3,3',4,4'-tetraaminobiphenyl, and post-sulfonation process. The sulfonic acid groups were precisely grafted onto the \n OUTPUT:\n " }, { "from": "agent", "value": "Novel Side-Chain Type Sulfonated Poly(phenylquinoxaline) Proton Exchange Membranes for Direct Methanol Fuel Cells." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Magneto-ionics, which deals with the change of magnetic properties through voltage-driven ion migration, is expected to be one of the emerging technologies to develop energy-efficient spintronics. While a precise modulation of magnetism is achieved when voltage is applied, much more uncontrolled is the spontaneous evolution of magneto-ionic systems upon removing the electric stimuli (\n OUTPUT:\n " }, { "from": "agent", "value": "Frequency-dependent stimulated and post-stimulated voltage control of magnetism in transition metal nitrides: towards brain-inspired magneto-ionics." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To compare the clinical efficacy of lumbar endoscopic Delta large channel and microscopic tubular Quadrant channel unilateral laminotomy with bilateral decompression in the treatment of elderly patients with lumbar spinal stenosis.\n OUTPUT:\n " }, { "from": "agent", "value": "Comparison of the short-term effects of lumbar endoscopic and microscopic tubular unilateral laminotomy with bilateral decompression in the treatment of elderly patients with lumbar spinal stenosis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Lipedema is a poorly known condition. Diagnosis is based almost exclusively on clinical criteria, which may be subjective and not always reliable. This study aimed to investigate regional body composition (BC) by dual-energy X-ray absorptiometry (DXA) in patients with lipedema and healthy controls and to determine cut-off values of fat mass (FM) indices to provide an additional tool for the diagnosis and staging of this condition.\n OUTPUT:\n " }, { "from": "agent", "value": "Body Composition Assessment by Dual-Energy X-Ray Absorptiometry: A Useful Tool for the Diagnosis of Lipedema." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Although the safety performance of the Australian commercial fishing industry has been the subject of multiple investigations, it has ultimately remained undefined. While most Australian industries notify industry regulators of significant workplace incidents and injuries in their operations, the majority of persons in the commercial fishing industry are contractors who are paid piecework and in some jurisdictions specifically excluded from the worker compensation legislation, meaning that most occupational injuries, including fatalities, are not captured in the centralized worker compensation data sets. This study presents the analysis of a systematic review of industry databases, published academic, and, Australian coroners reports to assist improve the definition of the nation's commercial fishing industry safety performance. The analysis shows occupational fatality rates are significantly higher than currently reported, and recurring factors contributing to deaths at sea remain unaddressed. The study is significant as it demonstrates how workplace injuries and deaths can be hidden within data sets applying broad industry classification and provides a foundation for future research in Australian fishing and other industries.\n OUTPUT:\n " }, { "from": "agent", "value": "Death at sea-the true rate of occupational fatality within the Australian commercial fishing industry." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Esophageal cancer (EC) is the sixth leading cause of cancer deaths worldwide. Nodal skip metastasis (NSM), a common form of lymphatic spread in EC, can be defined as the metastatic involvement of distant lymph nodes (LNs) without prior involvement of adjacent LNs. The results of the previous studies investigating the association between NSM and survival outcomes in patients with EC were inconsistent and even contradictory. The aim of this systematic review and meta-analysis is to investigate the prognostic value of NSM and to summarize the NSM definitions of EC in previous studies.\n OUTPUT:\n " }, { "from": "agent", "value": "The Prognostic Value of Nodal Skip Metastasis in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Sarcomas are a leading cause of cancer death in individuals younger than 20 years of age and represent the largest group of rare solid tumors. To date, more than 100 morphological subtypes of sarcomas have been described, among which epidemiology, clinical features, management, and prognosis differ significantly. Delays and errors in the diagnosis of sarcomas limit the number of effective therapeutic modalities and catastrophically worsen the prognosis. Therefore, the development of an algorithm for the early accurate diagnosis of sarcomas seems to be as important as the development of novel therapeutic advances. This literature review aims to summarize the results of recent investigations regarding the imaging of sarcoma progression based on the use of X-ray computed tomography (CT) in preclinical studies and in current clinical practice through the lens of cancer hallmarks. We attempted to summarize the main CT imaging features of soft-tissue and bone sarcomas. We noted the development of new molecular markers with high specificity to antibodies and chemokines, which are expressed in particular sarcoma subtypes to reach tumor type-specific imaging. We demonstrate the possibility of the use of X-ray computed microtomography (micro-CT) for non-destructive 3D visualization of solid tumors by increasing the visibility of soft tissues with X-ray scattering agents. Based on the results of recent studies, we hypothesize that micro-CT enables the visualization of neovascularization and stroma formation in sarcomas at high-resolution in vivo and ex vivo, including the novel techniques of whole-block and whole-tissue imaging. Finding correlations between CT, PET/CT, and micro-CT imaging features, the results of the histopathological specimen examination and clinical outcomes may significantly increase the accuracy of soft-tissue and bone tumor diagnostics, which leads to the initiation of appropriate histotype-specific management in a timely manner and, consequently, to improved outcomes.\n OUTPUT:\n " }, { "from": "agent", "value": "Imaging Hallmarks of Sarcoma Progression Via X-ray Computed Tomography: Beholding the Flower of Evil." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The quality of transurethral resection of bladder tumor (TURBT) markedly varies among surgeons and may have a considerable impact on treatment outcomes. The importance of a surgical checklist for TURBT has been suggested in order to standardize the procedure and improve surgical and oncological outcomes. In the present study, we verified the usefulness of a checklist for managing patients with non-muscle-invasive bladder cancer (NMIBC).\n OUTPUT:\n " }, { "from": "agent", "value": "Quality improvement in managing patients with non-muscle-invasive bladder cancer by introducing a surgical checklist for transurethral resection of bladder tumor." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Adolescents who are exposed to community violence are at risk for a number of adverse consequences that can persist into adulthood. Community violence exposure has consistently been associated with subsequent aggressive behavior, and beliefs or norms about aggression are one potential mechanism underlying this relation. The goal of this review was to examine and synthesize the literature regarding beliefs about aggression as a mediator of relations between community violence exposure and aggressive behavior among adolescents. A systematic search of the literature identified 10 studies that met inclusion criteria. Findings across studies generally supported the notion that beliefs about aggression mediate relations between community violence exposure and aggressive behavior. However, studies varied considerably in their design and analytic approach which limited conclusions that can be drawn. Because studies were similar in their limitations, several themes were identified and described qualitatively: inappropriate design to examine mediation (i.e., failure to establish temporal precedence of variables); examining a unidimensional construct of general beliefs about aggression; and lack of examining potential differences across subgroups, particularly across sex. Recommendations for future research that will bolster the evidence include drawing on advances in data analytic techniques, investigating multiple aspects of beliefs about aggression, examining differences in mediated effects across subgroups, and investigating beliefs as mechanisms of change in intervention studies. Implications for violence prevention efforts are discussed.\n OUTPUT:\n " }, { "from": "agent", "value": "Beliefs About Aggression as Mediators of Relations Between Community Violence Exposure and Aggressive Behavior Among Adolescents: Review and Recommendations." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Alkali metal dihydrogen-antimonides [M(L)\n OUTPUT:\n " }, { "from": "agent", "value": "Synthesis and Application of Alkali Metal Antimonide-A New Approach to Antimony Chemistry." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Exposure to tobacco products and advertising at the point of sale may be associated with pro-smoking cognitions. However, previous studies on this topic measured exposure based on self-report and did not include European countries. The aim of this study was to assess the association between objectively measured exposure to tobacco outlets and non-smoking adolescents' smoking attitudes, beliefs and norms.\n OUTPUT:\n " }, { "from": "agent", "value": "The association between objectively measured exposure to tobacco outlets and smoking cognitions: a study among non-smoking adolescents in four Dutch cities." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Despite the large body of research on sex differences in pain, there is a lack of translation to real-world pain management. Our aim was to analyse the sex differences in the analgesic response to oxycodone/naloxone (OXN) and tapentadol (TAP), in comparison with other opioids (OPO) commonly prescribed for chronic non-cancer pain (CNCP). An observational and cross-sectional study was conducted on ambulatory CNCP patients (\n OUTPUT:\n " }, { "from": "agent", "value": "Sex Differences in Oxycodone/Naloxone vs. Tapentadol in Chronic Non-Cancer Pain: An Observational Real-World Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Robots are increasingly being adopted in healthcare to carry out various tasks that enhance patient care. This scoping review aims to establish the types of robots being used in healthcare and identify where they are deployed.\n OUTPUT:\n " }, { "from": "agent", "value": "Robots in Healthcare: a Scoping Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Late complete atrioventricular block (CAVB) is a rare periprocedural complication in the treatment of atrioventricular (AV) nodal re-entrant tachycardia. However, it can necessitate permanent pacemaker implantation. We present a case of late CAVB that developed during the periprocedural period. Its pathogenesis was attributed to the indirect or functional effects on the fast pathway of the AV node due to the presence of paroxysmal supraventricular tachycardia with PR prolongation. Additionally, PR prolongation regressed to within the normal range after curing the late CAVB, and the advanced AV block with treadmill exercise stress test also improved 1:1 AV conduction with time. Periprocedural complications such as bradyarrhythmia may be reversible if late CAVB occurs within a few weeks after ablation. Thus, urgent permanent pacemaker implantation should be carefully considered.\n OUTPUT:\n " }, { "from": "agent", "value": "Late reversible complete atrioventricular block and PR interval normalization after antegrade slow pathway ablation for atrioventricular nodal re-entrant tachycardia with pre-existing PR prolongation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Usually, chromosome sets (karyotypes) and genome sizes are rather stable for distinct species and therefore of diagnostic value for taxonomy. In combination with (cyto)genomics, both features provide essential cues for genome evolution and phylogenetic relationship studies within and between taxa above the species level. We present for the first time a survey on chromosome counts and genome size measurement for one or more accessions from all 36 duckweed species and discuss the evolutionary impact and peculiarities of both parameters in duckweeds.\n OUTPUT:\n " }, { "from": "agent", "value": "Chromosome Numbers and Genome Sizes of All 36 Duckweed Species (" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Retinal diseases are major causes of irreversible vision loss and blindness. Despite extensive research into their pathophysiology and etiology, pharmacotherapy effectiveness and surgical outcomes remain poor. Based largely on numerous preclinical studies, administration of mesenchymal stem cells (MSCs) as a therapeutic strategy for retinal diseases holds great promise, and various approaches have been applied to the therapies. However, hindered by the retinal barriers, the initial vision for the stem cell replacement strategy fails to achieve the anticipated effect and has now been questioned. Accumulating evidence now suggests that the paracrine effect may play a dominant role in MSC-based treatment, and MSC-derived extracellular vesicles emerge as a novel compelling alternative for cell-free therapy. This review summarizes the therapeutic potential and current strategies of this fascinating class of cells in retinal degeneration and other retinal dysfunctions.\n OUTPUT:\n " }, { "from": "agent", "value": "Mesenchymal-Stem-Cell-Based Strategies for Retinal Diseases." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Fluid recirculation is an important function for organ-on-chip and microfluidic applications. For a systematic analysis, simultaneously applying multi-flow conditions in parallel channels is essential. However, control of parallel recirculation flows without using dynamic off-chip controllers that can drastically simplify device operation has been rarely implemented. In this study, we develop a microfluidic recirculation system driven only by water-head pressures. The pressures generated by reservoirs with <500 mL water volumes drive the system and recirculate <500 μL cell culture media volumes. The system realizes media recirculation in its four parallel channels with pulsatile and constant flows in a preprogrammed manner. The system, which consists of oscillator and cell culture modules, controls the flow rates and shear stress in wide ranges of 0.06-144 μL min\n OUTPUT:\n " }, { "from": "agent", "value": "Gravity-driven preprogrammed microfluidic recirculation system for parallel biosensing of cell behaviors." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: All species interact in complex antagonistic or mutualistic networks that may be driven by turnover in species composition due to spatiotemporal environmental filtering. Therefore, studying differences in insect communities along environmental gradients may improve our understanding of the abiotic and biotic factors that shape the structure of trophic networks. Parasitoids are interesting models to do so, due to their intimate eco-evolutionary relationship with their hosts. We explored the differences in cereal aphid-parasitoid food webs during the winter among nine localities in Chilean central-south valley, along a gradient of 1200 km from north (29° S) to south (40° S). We hypothesized that diapause incidence would increase in the coldest areas, resulting in a lower number of parasitoid species active during the winter. Consequently, network specialization, generality, and vulnerability indexes should increase with decreasing latitude, which implies fewer and more weakly connected links per parasitoid species through an increased fraction of basal host species. Based on the severity of winter, three areas along the explored gradient were distinguished, but clustering did not follow a clear north-south latitudinal gradient. Instead, few differences were observed in overwintering strategies, with very low levels of diapause in all localities, and no major differences in food-web composition. The major differences along the gradient were the relative abundances of the different aphid, parasitoid and hyperparasitoid species, with higher levels of spatial and temporal variation observed for the less abundant species. Our results provide a better understanding of the activity and abundance of aphid parasitoids during winter in relation to climatic conditions.\n OUTPUT:\n " }, { "from": "agent", "value": "Composition and structure of winter aphid-parasitoid food webs along a latitudinal gradient in Chile." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Infection with \n OUTPUT:\n " }, { "from": "agent", "value": "Gastrointestinal histoplasmosis complicating pediatric Crohn disease: A case report and review of literature." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The experiment was carried out in a reciprocating lubricated conformal sliding contact between steel discs of the same hardness. The effects of disc surface texturing on the friction coefficient at various operating conditions (temperature, normal load, and frequency of oscillations) were studied. Under various conditions, surface texturing caused friction reductions of sliding pairs. The largest reduction was 4.6 times at a lower temperature and 2.5 times at a higher temperature. The effect of the pit area ratio on the friction reduction was visible at a higher temperature. The highest dimple density of 25% corresponded to a lower coefficient of friction than the smallest density of 9%. The sliding pair with a dimple density of 17% led to large variation of the friction force. At lower temperatures, the coefficients of friction were lower compared to tests at higher temperatures.\n OUTPUT:\n " }, { "from": "agent", "value": "Effects of Operating Conditions and Pit Area Ratio on the Coefficient of Friction of Textured Assemblies in Lubricated Reciprocating Sliding." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The skull shapes of mammals diversified more rapidly early in their history.\n OUTPUT:\n " }, { "from": "agent", "value": "Bursts in skull evolution weakened with time." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Silicosis is a fibrotic lung disease caused by the inhalation of free crystalline silica. Its pathogenesis is extremely complex and involves a variety of cells. Exosomes emerge as a favorable candidate for communication between cells. LncRNA is a major component transported by exosomes in many inflammatory diseases. However, the role of exosomal lncRNA in the pathogenesis of silicosis is still unclear. In this study, the decreased expression of a novel exosomal lncRNA MSTRG.91634.7 in silicosis patients was identified according to high-throughput sequencing. Then, this macrophage-derived exosomal lncRNA MSTRG.91634.7 could regulate the fibroblast's activation by targeting PINK1 in a co-culture system of THP-1 and MRC-5. Finally, the mouse was exposed to 3 mg/50 μL silica to set up the silicosis model. AAV-ov-Pink1 was intratracheally injected to overexpress PINK1 in mice lungs. Our results suggested that PINK1, the target protein of lncRNA MSTRG.91634.7, participated in restricting the silica-induced lung inflammation and fibrosis in mice.\n OUTPUT:\n " }, { "from": "agent", "value": "Macrophage-derived exosomal lncRNA MSTRG.91634.7 inhibits fibroblasts activation by targeting PINK1 in silica-induced lung fibrosis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Doping analysis with a fast-turnaround-time reporting of 24/48 h is a \"traditional\" requirement for major competitions such as the Olympic Games, which require tremendously increased allocation of resources, especially during the COVID-19 pandemic. The \"Closed-Loop\" concept and operation mode established by the Beijing Organizing Committee for the 2022 Olympic and Paralympic Winter Games (BOCOG) provided a relatively isolated environment to non-Games-related civilians. To maintain this system, more than 200 persons were included as supporting crew of the laboratory with massive logistic resources allocated. The National Anti-Doping Laboratory in Beijing carried out the analysis mission of the Beijing 2022 Olympic and Paralympic Winter Games. During the Winter Olympics, 3165 samples were analyzed, whereas during the Paralympics, 679 samples were analyzed. The workforce accomplishing this work was composed of 36 domestic analysts, 20 international experts from other World Anti-Doping Agency-accredited laboratories, 61 university students with suitable majors, and 12 on-site instrumental engineers. This article summarizes the achievements from the laboratory's preparation phase; in-Game operational details such as instruments, methods, workforces, and facility; and the Quality Assurance measures to maintain the integrity and correctness of results reported to the Result Management Authority, with the effect of the pandemic and \"Closed-Loop\" situation during the whole process highlighted.\n OUTPUT:\n " }, { "from": "agent", "value": "Operation of the anti-doping laboratory for the Beijing 2022 Olympic and Paralympic Winter Games." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Qualitative research investigating pharmacists' participation in Long-Term Care (LTC) within interdisciplinary teams is scarce.\n OUTPUT:\n " }, { "from": "agent", "value": "Long-term care professionals' views on pharmacists: a qualitative study using Role Theory." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Assessing the adaptation of rectal temperature (T\n OUTPUT:\n " }, { "from": "agent", "value": "Using Predictive Modeling Technique to Assess Core Temperature Adaptations from Heart Rate, Sweat Rate, and Thermal Sensation in Heat Acclimatization and Heat Acclimation." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: We report the whole-genome sequence of a promising fish probiotic, Aneurinibacillus migulanus TP115, which was isolated from the gut of Nile tilapia (Oreochromis niloticus). The \n OUTPUT:\n " }, { "from": "agent", "value": "Whole-Genome Sequence of Aneurinibacillus migulanus TP115, a Potential Fish Probiotic Isolated from Oreochromis niloticus Gut." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Recently, ocular biometrics in unconstrained environments using images obtained at visible wavelength have gained the researchers' attention, especially with images captured by mobile devices. Periocular recognition has been demonstrated to be an alternative when the iris trait is not available due to occlusions or low image resolution. However, the periocular trait does not have the high uniqueness presented in the iris trait. Thus, the use of datasets containing many subjects is essential to assess biometric systems' capacity to extract discriminating information from the periocular region. Also, to address the within-class variability caused by lighting and attributes in the periocular region, it is of paramount importance to use datasets with images of the same subject captured in distinct sessions. As the datasets available in the literature do not present all these factors, in this work, we present a new periocular dataset containing samples from 1122 subjects, acquired in 3 sessions by 196 different mobile devices. The images were captured under unconstrained environments with just a single instruction to the participants: to place their eyes on a region of interest. We also performed an extensive benchmark with several Convolutional Neural Network (CNN) architectures and models that have been employed in state-of-the-art approaches based on Multi-class Classification, Multi-task Learning, Pairwise Filters Network, and Siamese Network. The results achieved in the closed- and open-world protocol, considering the identification and verification tasks, show that this area still needs research and development.\n OUTPUT:\n " }, { "from": "agent", "value": "A new periocular dataset collected by mobile devices in unconstrained scenarios." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Despite the strong link between cardiometabolic pregnancy complications and future heart disease, there are documented gaps in engaging those who experience such conditions in recommended postpartum follow-up and preventive care. The goal of our study was to understand how people in a Medicaid-insured population perceive and manage risks during and after pregnancy related to an ongoing cardiometabolic disorder.\n OUTPUT:\n " }, { "from": "agent", "value": "A Qualitative Study of Perceptions, Strengths, and Opportunities in Cardiometabolic Risk Management During Pregnancy and Postpartum in a Georgia Safety-Net Hospital, 2021." } ]