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PubMed_Summ_train

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[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: (1) Lockdown-related fatigue occurring during the COVID-19 pandemic is a complex problem that can be experienced in different social groups. The objective of the current study is to attempt to identify socio-demographic and lifestyle-related factors that determine the impact of fatigue on health in general as well as in physical, cognitive, and psychosocial terms and to determine whether, and to what extent, these were predictors of fatigue in nursing students during the COVID-19 pandemic. (2) The study was conducted by the diagnostic poll method between 20 March and 15 December 2021 among 894 nursing students at six Polish universities. To collect the data, a validated Modified Fatigue Impact Scale (MFIS) was used. (3) Students from the age group of ≤20 experienced a significantly greater impact of fatigue on health in general as well as in physical and cognitive terms. The study demonstrated a significant negative relationship between the year of study and the impact of fatigue on health in general terms (r = -0.12; \n OUTPUT:\n " }, { "from": "agent", "value": "Determinants of the Impact of Fatigue on the Health of Polish Nursing Students during the COVID-19 Pandemic." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cryptococcal meningitis is a common cause of AIDS-related mortality. Although symptom recurrence after initial treatment is common, the etiology is often difficult to decipher. We sought to summarize characteristics, etiologies and outcomes among persons with second-episode symptomatic recurrence.\n OUTPUT:\n " }, { "from": "agent", "value": "Recurrence of symptoms following cryptococcal meningitis - characterizing a diagnostic conundrum with multiple etiologies." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To evaluate the prognostic impact of serum uric acid (SUA) on clinical outcomes in patients with acute decompensated heart failure, as well as identify the correlation between hyperuricemia and renal function and diuretic resistance in these patients.\n OUTPUT:\n " }, { "from": "agent", "value": "[Prognostic impact of uric acid in patients with acute decompensated heart failure]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: COVID-19 is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It commonly affects the respiratory system, producing pneumonia-like symptoms. Among extrapulmonary manifestations, involvement of the gastrointestinal tract is common with symptoms of nausea, vomiting, diarrhea, and abdominal pain. Coronavirus acts by targeting the ACE-2 receptors in the alveoli of the lungs, but because these receptors are also present in other organs, such as the pancreas, it can affect the pancreas as well, thus causing acute pancreatitis. We here discuss a case of a 72-year-old hypertensive male with COVID-19 who presented with atypical presentation of acute abdominal pain and a few episodes of vomiting. Laboratory investigations were inconclusive. Imaging findings were suggestive of small bowel obstruction and perforation; thus, an exploratory laparotomy was done in which a mesenteric growth was found, reported as acute pancreatitis on histopathology. Therefore, attention should be paid to the pancreatic involvement and atypical presentations in COVID-19 patients.\n OUTPUT:\n " }, { "from": "agent", "value": "Acute pancreatitis masquerading as mesentric growth in COVID-19 patient: A case report." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The design of deep convolutional neural networks has resulted in significant advances and successes in the field of object detection. However, despite these achievements, the high computational and memory costs of such object detection networks on the edge or in mobile scenarios are one of the most significant barriers to their broad adoption. To solve this problem, this paper introduces an improved lightweight real-time convolutional neural network based on YOLOv5, called Alpha-SGANet: A multi-attention-scale feature pyramid network combined with a lightweight network based on Alpha-IoU loss. Firstly, we add one more prediction head to detect different-scale objects, design a lightweight and efficient feature extraction network using ShuffleNetV2 in the backbone, and reduce information loss using the SPP module with a smaller convolutional nucleus. Then, cleverly, employ GAFPN to improve feature transition processing in the neck region, including the usage of the Ghost module to construct efficient feature maps to help prediction. The CBAM module was further integrated to find areas of interest in the scene; finally, combined with Alpha-IOU loss for model supervision training, the biggest performance improvement was achieved. The experiment results show that, compared with YOLOv5s, our proposed method can achieve higher accuracy with fewer parameters and has real-time speed through verification on the PASCAL VOC dataset and MS COCO dataset.\n OUTPUT:\n " }, { "from": "agent", "value": "Alpha-SGANet: A multi-attention-scale feature pyramid network combined with lightweight network based on Alpha-IoU loss." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To generate and evaluate post-therapeutic optical coherence tomography (OCT) images based on pre-therapeutic images with generative adversarial network (GAN) to predict the short-term response of patients with retinal vein occlusion (RVO) to anti-vascular endothelial growth factor (anti-VEGF) therapy. Real-world imaging data were retrospectively collected from 1 May 2017, to 1 June 2021. A total of 515 pairs of pre-and post-therapeutic OCT images of patients with RVO were included in the training set, while 68 pre-and post-therapeutic OCT images were included in the validation set. A pix2pixHD method was adopted to predict post-therapeutic OCT images in RVO patients after anti-VEGF therapy. The quality and similarity of synthetic OCT images were evaluated by screening and evaluation experiments. We quantitatively and qualitatively assessed the prognostic accuracy of the synthetic post-therapeutic OCT images. The post-therapeutic OCT images generated by the pix2pixHD algorithm were comparable to the actual images in edema resorption response. Retinal specialists found most synthetic images (62/68) difficult to differentiate from the real ones. The mean absolute error (MAE) of the central macular thickness (CMT) between the synthetic and real OCT images was 26.33 ± 15.81 μm. There was no statistical difference in CMT between the synthetic and the real images. In this retrospective study, the application of the pix2pixHD algorithm objectively predicted the short-term response of each patient to anti-VEGF therapy based on OCT images with high accuracy, suggestive of its clinical value, especially for screening patients with relatively poor prognosis and potentially guiding clinical treatment. Importantly, our artificial intelligence-based prediction approach's non-invasiveness, repeatability, and cost-effectiveness can improve compliance and follow-up management of this patient population.\n OUTPUT:\n " }, { "from": "agent", "value": "Predicting OCT images of short-term response to anti-VEGF treatment for retinal vein occlusion using generative adversarial network." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Enteroviruses are members of the \n OUTPUT:\n " }, { "from": "agent", "value": "Activation of Host Cellular Signaling and Mechanism of Enterovirus 71 Viral Proteins Associated with Hand, Foot and Mouth Disease." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Bloodstream infections are a leading cause of morbidity and mortality. The rapid diagnostic testing of positive blood cultures (PBCs) shortens times to effective therapy and the de-escalation of broad-spectrum empiric therapy. This is the first study examining the Qvella FAST\n OUTPUT:\n " }, { "from": "agent", "value": "Direct MALDI-TOF MS and Antimicrobial Susceptibility Testing of Positive Blood Cultures Using the FAST" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Communicable respiratory viral infections pose both epidemic and pandemic threats and broad-spectrum antiviral strategies could improve preparedness for these events. To discover host antiviral restriction factors that may act as suitable targets for the development of host-directed antiviral therapies, we here conduct a whole-genome CRISPR activation screen with influenza B virus (IBV). A top hit from our screen, beta-1,3-glucuronyltransferase 1 (B3GAT1), effectively blocks IBV infection. Subsequent studies reveal that B3GAT1 activity prevents cell surface sialic acid expression. Due to this mechanism of action, B3GAT1 expression broadly restricts infection with viruses that require sialic acid for entry, including Victoria and Yamagata lineage IBVs, H1N1/H3N2 influenza A viruses (IAVs), and the unrelated enterovirus D68. To understand the potential utility of B3GAT1 induction as an antiviral strategy in vivo, we specifically express B3GAT1 in the murine respiratory epithelium and find that overexpression is not only well-tolerated, but also protects female mice from a lethal viral challenge with multiple influenza viruses, including a pandemic-like H1N1 IAV. Thus, B3GAT1 may represent a host-directed broad-spectrum antiviral target with utility against clinically relevant respiratory viruses.\n OUTPUT:\n " }, { "from": "agent", "value": "Cellular glycan modification by B3GAT1 broadly restricts influenza virus infection." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Osteoporosis is a highly prevalent condition affecting a growing number of patients affected by chronic obstructive pulmonary disease (COPD), with crucial implications for risk of fragility fractures, hospitalization, and mortality. Several risk factors have been identified to have a role in osteoporosis development in COPD patients, including corticosteroid therapy, systemic inflammation, smoke, physical activity levels, malnutrition, and sarcopenia. In this scenario, a personalized multitarget intervention focusing on the pathological mechanisms underpinning osteoporosis is mandatory to improve bone health in these frail patients. Specifically, physical exercise, nutritional approach, dietary supplements, and smoke cessation are the cornerstone of the lifestyle approach to osteoporosis in COPD patients, improving not only bone health but also physical performance and balance. On the other hand, pharmacological treatment should be considered for both the prevention and treatment of osteoporosis in patients at higher risk of fragility fractures. Despite these considerations, several barriers still affect the integration of a personalized approach to managing osteoporosis in COPD patients. However, digital innovation solutions and telemedicine might have a role in optimizing sustainable networking between hospital assistance and community settings to improve bone health and reduce sanitary costs of the long-term management of COPD patients with osteoporosis.\n OUTPUT:\n " }, { "from": "agent", "value": "Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: As the construction industry is striding towards the industrialization of green buildings, a precast concrete frame beam-column joint with high-strength reinforcement was proposed. Simulate reversed cyclic loading was carried out on two precast connections and one cast-in-place connection to examine the seismic behavior of the proposed new precast connection. The main test variables between the two precast connections were the strength of the reinforcement at the bottom of the beam. The failure shape, hysteresis curve, skeleton curve, strength, deformation ability, stiffness degradation, and energy dissipation were monitored and compared with the cast-in-place connection. The findings of this paper showed that the precast joints had good strength reserve, and the seismic performance in the later stage of loading even exceeds the cast-in-place joints. It was also found that the plastic hinge zone of the beam could be moved away from the column surface via reinforcement method. Additionally, based on the experiment, a detailed nonlinear finite element analysis (FEA) method was developed to reproduce the test response of specific types of bending moment-resistant precast concrete beam-column connections under a reversed loading test, which provided a theoretical reference for further research of the connections.\n OUTPUT:\n " }, { "from": "agent", "value": "Seismic Performance of Precast Concrete Frame Beam-Column Connections with High-Strength Bars." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In order to effectively monitor toxic and harmful substances in sewage discharge, a rapid, highly sensitive detection of complex pollutants with similar structures has become an urgent problem to be solved. In this paper, a supramolecular colorimetric array sensor based on charge-transfer complex was constructed, which can quickly detect aniline and phenol pollutants (such as p-phenylenediamine, m-phenylenediamine, o-phenylenediamine, m-aminophenol, hydroquinone, and resorcinol) with similar structures. When six anilines and phenol isomers with similar structures were added to the supramolecular colorimetric array sensor, different color changes were produced under natural light. Linear discriminant analysis (LDA) showed that the supramolecular colorimetric array sensor could recognize and distinguish these isomers, and a mixture with different concentration ratios could be well categorized. The total Euclidean distance (TED) of an array with pollutant concentrations had a good linear correlation, and the detection limit (LOD) was as low as 10\n OUTPUT:\n " }, { "from": "agent", "value": "A colorimetric supramolecular sensor array based on charge-transfer complexes for multiplex aniline and phenolic pollutants detection." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The distribution and migration of heavy metal(loid)s in the soil-vegetable systems of courtyard gardens near mining areas have rarely been investigated, leading to potential food safety risks for residents. Moreover, the existing research is mainly focused on the total content of heavy metal(loid)s (tMetals) rather than the bioavailable contents (aMetals). In this study, 26 and 28 pairs of soil and vegetable samples were collected from the courtyard gardens near the Realgar mine in Baiyun Town and the lead-zinc (Pb-Zn) mine in Shuikoushan Town, respectively. The tMetal and aMetal of cadmium (Cd), mercury (Hg), arsenic (As), Pb, chromium (Cr), nickel (Ni), copper (Cu), Zn, manganese (Mn), iron (Fe), and calcium (Ca) in the samples were analyzed in this study. The results showed that courtyard gardens were polluted by various heavy metal(loid)s at varying degrees. The bioavailabilities of different metals varied significantly, among which Cd has the highest bioavailability (> 30%). In the transfer process of heavy metal(loid)s, the transfer rate (Tf) was ranked as soil-roots (1.50) > stems-leaves (1.07) > roots-stems (0.46) > stems-fruits (0.33). Redundancy analysis was used to evaluate the driving effects, and the results revealed that aCa, aZn, and aFe in soil could inhibit the absorption of aCd by plant roots. Soil organic matter was the inhibiting factor regarding the transfer of aAs and aCu, whereas it was also the promoting factor for transferring aPb, aNi, and aCr. Furthermore, the multilayer perceptron (MLP) could effectively predict the Tf of heavy metal(loid)s based on the aMetal. The R\n OUTPUT:\n " }, { "from": "agent", "value": "Driving effects and transfer prediction of heavy metal(loid)s in contaminated courtyard gardens using redundancy analysis and multilayer perceptron." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: While challenges facing community and acute care practitioners have been studied elsewhere, this is not the case for respiratory therapists (RTs). This study aimed to examine attitudinal differences amongst RTs in British Columbia regarding challenges faced by acute and community settings.\n OUTPUT:\n " }, { "from": "agent", "value": "A survey on the attitudinal differences between acute and community settings." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Syphilis can cause a wide range of systemic manifestations, such as papular rash, malaise, weight loss, muscle aches, generalized lymphadenopathy, and meningitis. However, pulmonary involvement in patients with secondary syphilis is thought to be relatively rare. Moreover, bone involvement in patients with secondary syphilis is also considered rare, and only a few cases of involvement of lung and bone in such patients have been reported. In this paper, we report a case of secondary syphilis with pulmonary involvement in the form of multiple nodules with low attenuation areas, lymphadenopathy and multiple bone lesions detected on computed tomography and 18F fluorodeoxyglucose-positron emission tomography/computed tomography.\n OUTPUT:\n " }, { "from": "agent", "value": "Syphilis With Multiple Pulmonary Nodules and Bone Lesions Detected on Computed Tomography and 18F Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The relationship between the tortuosity of the parent artery and treatment outcomes is not well established. We investigate the association between parent artery tortuosity and flow diverter (FD) treatment outcomes in patients with internal carotid artery aneurysms in this study.\n OUTPUT:\n " }, { "from": "agent", "value": "Tortuosity of parent artery predicts in-stent stenosis after pipeline flow-diverter stenting for internal carotid artery aneurysms." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The combination of oncolytic viruses (OVs) with immune checkpoint blockades is a research hotspot and has shown good efficacy. Here, we present the first attempt to combine oncolytic herpes simplex virus 2 (OH2) with an anti-SIRPα antibody as an antitumour treatment. Our results provide unique insight into the combination of innate immunity with OV.\n OUTPUT:\n " }, { "from": "agent", "value": "SIRPα antibody combined with oncolytic virus OH2 protects against tumours by activating innate immunity and reprogramming the tumour immune microenvironment." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Gastric-type mucinous endocervical adenocarcinomas (GAS) are new variant types of cervical adenocarcinomas according to the 2014 World Health Organization (WHO) classification. GAS is a unique disease that can be differentiated from typical adenocarcinomas-it is less common and more aggressive and likely to have deep invasion and horizontal diffusion, invasion of the uterus and vagina, early distant metastases, and a lower 5-year survival rate compared to the usual-type cervical cancer. At present, initial treatment and postoperative adjuvant therapy are not conclusive, but early detection and early treatment are a consensus that can improve prognosis. Most of its occurrence has nothing to do with human papillomavirus (HPV) infection. Whether it is only negative for the subtypes that can be detected at present and whether it may be an unknown subtype of infection need to be further explored in the future. The clinical symptoms commonly include aqueous secretion, lower abdominal pain, and elevated serum carbohydrate antigen-19-9 (CA19-9) levels, which may be helpful for diagnosis. MRI and PET-CT can help to describe the characteristics of lesions and judge the state of the systemic metastasis. We believe that early detection and surgical treatment will give patients more benefits. Looking for potential gene and molecular changes and establishing biomarkers to identify molecular targets will be the key to early identification and target therapy.\n OUTPUT:\n " }, { "from": "agent", "value": "Gastric-type mucinous endocervical adenocarcinomas: A case report and literature review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Hexafluoropropylene oxide dimer acids (HFPO-DA) and hexafluoropropylene oxide trimer acids (HFPO-TA) are alternatives to perfluorooctanoic acid (PFOA). However, little information on the comparison of their toxicities is available. Here, zebrafish embryos were exposed to PFOA, HFPO-DA, and HFPO-TA with exposure concentrations of 5 and 500 μg/L. Behavioral abnormal, enzyme activities and gene expression profiles in zebrafish embryos were determined. Results showed that exposure to PFOA and its alternatives increased heart rates and inhibited locomotor activity of zebrafish embryos. Further, their exposures changed the enzyme activities (acetylcholinesterase and oxidative stress-related enzymes), ATP content, and expressions of genes related to hypothalamic-pituitary-thyroid (HPT) axis, apoptosis, and lipid metabolism. Comparison analyses found that PFOA, HFPO-TA, and HFPO-DA exposures induced different effects on the embryonic development of zebrafish, which indicates the different modes of action. The HFPO-DA exposure induced specific effects on the disorder of lipid metabolism, HPT axis, and neurodevelopment. The HFPO-TA exposure also induced different effects from the PFOA exposure, which focused on lipid metabolism. The current data shows that the HFPO-DA and HFPO-TA might not be safe alternatives to PFOA. This study provides a new understanding of the biological hazards of PFOA alternatives in aquatic organisms, which can guide their usage.\n OUTPUT:\n " }, { "from": "agent", "value": "Comparison of developmental toxicity induced by PFOA, HFPO-DA, and HFPO-TA in zebrafish embryos." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Multiple choice questions (MCQs) suffer from cueing, item quality and factual knowledge testing. This study presents a novel multimodal test containing alternative item types in a computer-based assessment (CBA) format, designated as Proxy-CBA. The Proxy-CBA was compared to a standard MCQ-CBA, regarding validity, reliability, standard error of measurement, and cognitive load, using a quasi-experimental crossover design. Biomedical students were randomized into two groups to sit a 65-item formative exam starting with the MCQ-CBA followed by the Proxy-CBA (group 1, \n OUTPUT:\n " }, { "from": "agent", "value": "Utility of a multimodal computer-based assessment format for assessment with a higher degree of reliability and validity." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Hyperuricemia (HUA) refers to a physiological condition of high serum uric acid (SUA) level in the body, which may cause an increased risk of several chronic diseases. The kidney's impaired uric acid (UA) metabolism is an important reason for HUA. In this study, we tested the hypothesis that circulating factors produced during exercise regulate the expression of ABCC4, ABCG2, URAT1, and GLUT9 in normal rat kidneys and normal rat kidney cells (NRK-52E) and their relationship with NF-κB and NRF-2. NRK-52E cells were separately cultured by serum from 10 healthy SD rats who did not exercise (CON) and 10 healthy SD rats who did aerobic treadmill exercise for 6 weeks. Cells cultured by serum from rats who did aerobic treadmill exercise for 6 weeks were separated by without NRF-2 inhibitor (EXE) and with NRF-2 inhibitor (EXE + ML). SUA level of rats was tested by using dry chemical assays, xanthine oxidase (XOD) activity in serum and liver were tested by using enzyme colorimetry assays, protein expression in kidney and NRK-52E cells were tested by using Western-blot, and UA levels in the upper or lower chamber were tested by colorimetry assays. Aerobic exercise reduced SUA levels in rats but did not significantly affect on liver xanthine oxidase. It also increased the expression of some UA transporters in the kidney and NRK-52E cells and increased the cells' ability in UA excretion. When the NRF-2 was inhibited, the NF-κB and ABCG2 increased, and the expression of ABCC4, URAT1, and GLUT9 decreased. In conclusion, this study suggested that 6 weeks of aerobic treadmill exercise intervention may help to improve the excretion of UA in renal cells, suggesting that long-term aerobic exercise may be a means to prevent hyperuricemia.\n OUTPUT:\n " }, { "from": "agent", "value": "Exercise serum regulates uric acid transporters in normal rat kidney cells." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: We have used quantum chemical methods to study the structural principles and energetics of A-site ordered AA'B\n OUTPUT:\n " }, { "from": "agent", "value": "Structural principles of cation ordering and octahedral tilting in A-site ordered double perovskites: ferroelectric CaMnTi" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This work presents the design and fabrication of a metamaterial-based stimulated dual band antenna on FR4 material (dielectric constant 4.3) to operate in Industrial, Scientific and Medical (ISM) and Radio-frequency Identification (RFID) applications. The antenna model had an overall dimension of 70 × 31 × 1.6 mm\n OUTPUT:\n " }, { "from": "agent", "value": "A Metamaterial Inspired AMC Backed Dual Band Antenna for ISM and RFID Applications." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The effect of antibiotics on the human microbiome is now well established, but their indirect effect on the related immune response is less clear. The possible association of Herpes zoster, which involves a reactivation of a previous varicella zoster virus infection, with prior antibiotic exposure might indicate a potential link with the immune response.\n OUTPUT:\n " }, { "from": "agent", "value": "Prior antibiotics and risk of subsequent Herpes zoster: A population-based case control study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: COVID-19 has widened the existing digital divide, especially for people from socially and economically deprived communities. We describe a program evaluation using a community participatory approach to develop self-reported items of patient experience with technology inclusive of digital access and literacy. The feedback received from Community Advisory Boards and Community Engagement Studio members led to the evaluation and refinement of the individual items. The community-based participatory approach highlighted in our paper to develop these items could serve as a model for other screening tool development for enhancing equity and inclusiveness in clinical care and research.\n OUTPUT:\n " }, { "from": "agent", "value": "Development and initial cognitive testing of the Digital Equity Screening Tool (DEST): Community participatory approach to assessing digital inequality." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Tetra-\n OUTPUT:\n " }, { "from": "agent", "value": "Design and Synthesis of Visible-Light-Responsive Azobenzene Building Blocks for Chemical Biology." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Squamous cell carcinoma in situ of the hand and nail is an infrequent tumor but represents the majority of hand and nail malignancies. While the conventional treatments of invasive nail unit squamous cell carcinoma include Mohs micrographic surgery, wide local excision, or distal digit amputation, no standardized management paradigm for in situ disease exists and the necessity of surgical options is debated. This review aims to discuss the most commonly reported treatment methods and critically assess relevant management considerations in order to facilitate appropriate treatment decisions for nail unit SCCis across dermatologic practice settings. Assessment of the current literature reveals insufficient evidence to determine a standardized treatment for nail unit squamous cell carcinoma in situ. Rather, management is greatly impacted by multiple factors including the presence of subungual involvement, surgical candidacy, importance of curative treatment, and patient preferences regarding cosmesis and function versus cure. When cure is desired, Mohs micrographic surgery is the treatment of choice in most cases. In the setting of desired curative intent, but poor surgical candidacy, radiotherapy may be effective and provide a reasonable chance of functional and cosmetic preservation. Other methods including photodynamic therapy, electrodesiccation and curettage, cryotherapy, and intralesional chemotherapeutics may be appropriate in specific circumstances, but are generally limited by lack of evidence or impracticalities. Lastly, observation with palliation may be appropriate when considering exceedingly rare disease-related mortality.\n OUTPUT:\n " }, { "from": "agent", "value": "Squamous Cell Carcinoma in Situ of the Nail Unit: Current Evidence and Recommendations for Patient Centered Treatment." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Parkinson's disease (PD) is characterized by motor disabilities precipitated by α-synuclein aggregation and dopaminergic neurodegeneration. The roles of oxidative stress, neuroinflammation, dysfunction of the mitogen-activated protein kinase (MAPK) pathway, and apoptosis in dopaminergic neurodegeneration have been established. We investigated the potential neuroprotective effect of xanthotoxin, a furanocoumarin extracted from family Apiaceae, in a rotenone-induced PD model in rats since it has not yet been elucidated.\n OUTPUT:\n " }, { "from": "agent", "value": "Xanthotoxin modulates oxidative stress, inflammation, and MAPK signaling in a rotenone-induced Parkinson's disease model." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation. P2X7 has also emerged as an attractive therapeutic target for inflammatory brain diseases. However, little is known about the ability of nanobodies to cross the BBB. Here we evaluated the ability of P2X7-specific nanobodies to reach and to block P2X7 on microglia following intravenous or intracerebral administration. For this study, we reformatted and sequence-optimized P2X7 nanobodies for higher stability and elevated isoelectric point. Following injection of nanobodies or nanobody-encoding adeno-associated viral vectors (AAV), we monitored the occupancy and blockade of microglial P2X7 \n OUTPUT:\n " }, { "from": "agent", "value": "Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: How exploding stars forge elements could be harder to trace.\n OUTPUT:\n " }, { "from": "agent", "value": "New sodium isotope challenges theories of exotic atomic nuclei." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Lumbar epidural analgesia (EA) is the most commonly used method for reducing labour pain, but its impact on the duration of the second stage of labour and on neonatal and maternal outcomes remains a matter of debate. Our aim was to examine whether EA affected the course and the outcomes of labour among patients divided according to the Robson-10 group classification system.\n OUTPUT:\n " }, { "from": "agent", "value": "The Effect of Epidural Analgesia on Labour and Neonatal and Maternal Outcomes in 1, 2a, 3, and 4a Robson's Classes: A Propensity Score-Matched Analysis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Institutions sponsoring athletics must be prepared for emergencies. Due to this, more governing bodies are requiring a sports-related emergency action plan (EAP). Yet, the effects of these policies are unknown. We compared adoption of EAPs and associated best practices in Oregon high schools before and after a policy requiring an EAP. Athletic directors were invited to complete a survey during the year before the policy went into effect and again the following year. We assessed whether the school had a written EAP and if they did, was the EAP venue specific, available at the venue, distributed to personnel, and annually reviewed and rehearsed. Pre/post-policy proportions were analyzed using Fisher exact tests for all schools and then schools that completed both surveys. There was a significant increase of schools that reported having an EAP after the policy went into effect (all schools: 55% to 99% [\n OUTPUT:\n " }, { "from": "agent", "value": "The Effect of a Statewide Policy on High School Emergency Action Plans." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Breastmilk contains many important nutrients, anti-inflammatory agents, and immunomodulators. It is the preferred nutrition source for infants. However, the association of the duration of exclusive breastmilk feeding (BMF) with asthma development is unclear. Data on children from the United States who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2014 were obtained. We examined the association between the duration of exclusive BMF and asthma in 6000 children (3 to 6 years old). After calculating the duration of exclusive breastfeeding according to answers to NHANES questionnaires, the estimated duration of exclusive BMF was divided into five categories: never breastfed or BMF for 0 to 2 months after birth; BMF for 2 to 4 months after birth; BMF for 4 to 6 months after birth; and BMF for ≥6 months after birth. The overall prevalence of asthma in children aged 3 to 6 years was approximately 13.9%\n OUTPUT:\n " }, { "from": "agent", "value": "Association of Exclusive Breastfeeding with Asthma Risk among Preschool Children: An Analysis of National Health and Nutrition Examination Survey Data, 1999 to 2014." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Shoot cultures of hypericin non-producing \n OUTPUT:\n " }, { "from": "agent", "value": "Evolutionary Aspects of Hypericin Productivity and Endogenous Phytohormone Pools Evidenced in " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: A substantial proportion of the population of females in India falls in the perimenopausal and postmenopausal age groups. One of the complications associated with older age in women is the weakening of bones and the fall in bone mineral density (BMD). This has a severe debilitating consequence in a woman's life and leads to reduced quality of life along with a greater incidence of fractures. If the fracture involves the hip or the vertebrae, it can cause immobility and be devastating. Postmenopausal osteoporosis is linked with the deficiency of estrogen that occurs with the cessation of the function of the ovaries as age progresses. The function of estrogen in the bone remodeling process is very well understood after years of research; estrogen plays a part in both the formation of bone as well as the prevention of the resorption of bone. A diagnosis can be made by dual-energy X-ray absorptiometry (DEXA). It is the gold standard and can spot low bone density at particular sites. The treatment options are selected according to the severity and rate of progression and factors pertaining to each patient. All postmenopausal women should be made aware of this disorder, and they should be encouraged to cultivate a healthy lifestyle through the implementation of a proper diet and inculcation of a regular exercise routine. Smoking and drinking alcohol should be limited, and calcium and vitamin D supplementation should be started in all women of the postmenopausal age group with or without osteoporosis. In patients who have been diagnosed with the disorder, pharmacological intervention is done. Drugs should be selected based on their side effects and contradictions. Follow-up is essential, and patient compliance should be carefully monitored. This article attempts to review the existing literature on this very prevalent disorder to spread awareness about it so that all postmenopausal women can take the necessary steps to prevent the weakening of their bones, and deal with its progression.\n OUTPUT:\n " }, { "from": "agent", "value": "Postmenopausal Osteoporosis: A Literature Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In this study, the effect of media composition, N/P ratio and cultivation strategy on the formation of carotenoids in a \n OUTPUT:\n " }, { "from": "agent", "value": "Formation of Lutein, β-Carotene and Astaxanthin in a " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: A structured approach in the diagnostic process of hypoglycemia is important to find the right diagnosis. The first step is to recognize the symptoms of hypoglycemia, confirming the hypoglycemia during symptoms and dissolvement of complaints once the glucose level is restored to normal. This confirms the Whipple triad. The second step is to exclude common causes. The third, and most important, step is a diagnostic fasting test. Measurement of insulin and C-peptide during hypoglycemia will guide to exogenic or endogenic causes of hyperinsulinism. Targeted additional investigation is then required. Often the underlying cause is treatable. This justifies the need to measure a well-timed serum glucose when hypoglycemia is suspected to make a quick diagnosis.\n OUTPUT:\n " }, { "from": "agent", "value": "[Hypoglycaemia in patients without diabetes mellitus]." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Perovskite solar cells (PSCs) are being developed rapidly and exhibit greatly potential commercialization. Herein, it is found that the device performance can be improved by manipulating the migration of iodine ions via reverse-biasing, for example, at -0.4 V for 3 min in dark. Characterizations suggest that reverse bias can increase the charge recombination resistance, improve carrier transport, and enhance built-in electric field. Iodine ions including iodine interstitials in perovskites are confirmed to migrate and accumulate at the SnO\n OUTPUT:\n " }, { "from": "agent", "value": "Manipulating the Migration of Iodine Ions via Reverse-Biasing for Boosting Photovoltaic Performance of Perovskite Solar Cells." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Thousands of buildings in Cleveland, Ohio were demolished or rehabilitated since the Great Recession in the 2000s. Recent evidence suggests removing vacant and decaying buildings reduces violent and firearm-involved crime. This study examines the dose-response relationship between demolitions, rehabilitations, and crime. We use Bayesian spatiotemporal models to estimate the association of interest for five types of crime outcomes: violent crimes, violent crimes involving a firearm, drug crimes, and crimes often associated with building vacancy. We estimate associations in quarterly time periods from 2012 through 2017 in 569 hexagons approximately the size of a neighborhood (2000 feet, approximately 610 m, in diameter), stratified by vacancy level. Across vacancy levels, the majority of our models do not identify statistically significant associations between demolition and rehabilitation dose and crime incidence. However, in some cases, we identify positive associations between demolition and crime. These associations generally appeared at higher levels of demolition (2 or 3 or more demolitions) in areas characterized by medium to high levels of vacancy. We also find that the presence of a property rehabilitation is associated with an increase in drug crimes in areas with medium levels of vacancy.\n OUTPUT:\n " }, { "from": "agent", "value": "Crime and Building Rehabilitation or Demolition: A Dose-Response Analysis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Wearable digital health technologies (DHTs) have the potential to improve chronic kidney disease (CKD) management through patient engagement. This study aimed to investigate and elicit preferences of individuals with CKD toward wearable DHTs designed to support self-management of their condition.\n OUTPUT:\n " }, { "from": "agent", "value": "Using discrete-choice experiments to elicit preferences for digital wearable health technology for self-management of chronic kidney disease." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The positive effects of both antipsychotic medication and cognitive behavioral therapy in psychosis (CBTp) for people who are distressed by their experience of hearing voices remain limited. As a result, there has been a recent surge in talk-based individual approaches. Many of these continue not to be very well known nor implemented in practice. Some of the approaches may focus more on understanding and dealing constructively with voices, an element that has been identified as potentially helpful by voice hearers. Existing barriers to a wider implementation include both the widespread pathologization of hearing voices and a lack of mental health professionals who have been trained and trusted to carry out these new interventions.\n OUTPUT:\n " }, { "from": "agent", "value": "Talk-based approaches to support people who are distressed by their experience of hearing voices: A scoping review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Hemifacial spasm (HFS) due to an arachnoid cyst at the cerebellopontine angle is rare. Here, the authors reported such a case and analyzed the mechanism of facial nerve hyperactivity by reviewing the literature.\n OUTPUT:\n " }, { "from": "agent", "value": "Arachnoid cyst alone causes hemifacial spasm: illustrative case." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Antimicrobial Photodynamic Treatment (aPDT) is a non-thermal sterilization technology, which can inactivate common foodborne pathogens. In the present study, photodynamic inactivation on \n OUTPUT:\n " }, { "from": "agent", "value": "Antibacterial Efficacy and Mechanisms of Curcumin-Based Photodynamic Treatment against " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Temporin family is one of the largest among antimicrobial peptides (AMPs), which act mainly by penetrating and disrupting the bacterial membranes. To further understand the relationship between the physical-chemical properties and their antimicrobial activity and selectivity, an analogue of Temporin L, [Nle\n OUTPUT:\n " }, { "from": "agent", "value": "Synthetic Amphipathic β-Sheet Temporin-Derived Peptide with Dual Antibacterial and Anti-Inflammatory Activities." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: A 57-year-old female presented with headache and dizziness for 3 months. Preoperative MRI revealed a lesion located at the pineal region and back side of the third ventricle, accompanied by hydrocephalus. The infratentorial supracerebellar approach may cause visuomotor, acousticomotor, and hearing disturbances. With the patient in a supine position, the authors used a frontal linear incision that was 3 cm anterior to the coronal suture and 2 cm away from the midline and an anterior endoscopic transcortical approach, which could achieve endoscopic third ventriculostomy, alleviating and preventing hydrocephalus due to postoperative adhesion and resection of the lesion at the same time. The pathological diagnosis was cavernous hemangioma. The video can be found here: https://stream.cadmore.media/r10.3171/2021.4.FOCVID215.\n OUTPUT:\n " }, { "from": "agent", "value": "Anterior endoscopic transcortical approach to a pineal region cavernous hemangioma." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: To evaluate the potential of a novel system using outlier detection screening algorithms and to identify medication related risks in an inpatient setting.\n OUTPUT:\n " }, { "from": "agent", "value": "Screening for Medication Errors and Adverse Events Using Outlier Detection Screening Algorithms in an Inpatient Setting." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: We thank you and your co-authors for the comment [...].\n OUTPUT:\n " }, { "from": "agent", "value": "Reply to De Giorgi et al. Comment on \"Kesić et al. Early Diagnostics of Vulvar Intraepithelial Neoplasia. " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: to create and validate a high-fidelity simulation scenario about the initial support to suicide bereaved people.\n OUTPUT:\n " }, { "from": "agent", "value": "Creation and validation of a high-fidelity simulation scenario for suicide postvention." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Pancreatic ductal adenocarcinoma (PDAC) is caused by genetic mutations in four genes: KRAS proto-oncogene and GTPase (<i>KRAS</i>), tumor protein P53 (<i>TP53</i>), cyclin-dependent kinase inhibitor 2A (<i>CDKN2A</i>), and mothers against decapentaplegic homolog 4 (<i>SMAD4</i>), also called the big 4. The changes in tumors are very complex, making their characterization in the early stages challenging. Therefore, the development of innovative therapeutic approaches is desirable. The key to overcoming PDAC is diagnosing it in the early stages. Therefore, recent studies have investigated the multifaced characteristics of PDAC, which includes cancer cell metabolism, mesenchymal cells including cancer-associated fibroblasts and immune cells, and metagenomics, which extend to characterize various biomolecules including RNAs and volatile organic compounds. Various alterations in the <i>KRAS</i>-dependent as well as <i>KRAS</i>-independent pathways are involved in the refractoriness of PDAC. The optimal combination of these new technologies is expected to help treat intractable pancreatic cancer.\n OUTPUT:\n " }, { "from": "agent", "value": "Pancreatic Cancer Research beyond DNA Mutations." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In the cold deserts of the McMurdo Dry Valleys (MDV) the suitability of soil for microbial life is determined by both contemporary processes and legacy effects. Climatic changes and accompanying glacial activity have caused local extinctions and lasting geochemical changes to parts of these soil ecosystems over several million years, while areas of refugia may have escaped these disturbances and existed under relatively stable conditions. This study describes the impact of historical glacial and lacustrine disturbance events on microbial communities across the MDV to investigate how this divergent disturbance history influenced the structuring of microbial communities across this otherwise very stable ecosystem. Soil bacterial communities from 17 sites representing either putative refugia or sites disturbed during the Last Glacial Maximum (LGM) (22-17 kya) were characterized using 16 S metabarcoding. Regardless of geographic distance, several putative refugia sites at elevations above 600 m displayed highly similar microbial communities. At a regional scale, community composition was found to be influenced by elevation and geographic proximity more so than soil geochemical properties. These results suggest that despite the extreme conditions, diverse microbial communities exist in these putative refugia that have presumably remained undisturbed at least through the LGM. We suggest that similarities in microbial communities can be interpreted as evidence for historical climate legacies on an ecosystem-wide scale.\n OUTPUT:\n " }, { "from": "agent", "value": "Glacial Legacies: Microbial Communities of Antarctic Refugia." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Adaptive sensory behavior is thought to depend on processing in recurrent cortical circuits, but how dynamics in these circuits shapes the integration and transmission of sensory information is not well understood. Here, we study neural coding in recurrently connected networks of neurons driven by sensory input. We show analytically how information available in the network output varies with the alignment between feedforward input and the integrating modes of the circuit dynamics. In light of this theory, we analyzed neural population activity in the visual cortex of mice that learned to discriminate visual features. We found that over learning, slow patterns of network dynamics realigned to better integrate input relevant to the discrimination task. This realignment of network dynamics could be explained by changes in excitatory-inhibitory connectivity among neurons tuned to relevant features. These results suggest that learning tunes the temporal dynamics of cortical circuits to optimally integrate relevant sensory input.\n OUTPUT:\n " }, { "from": "agent", "value": "Learning shapes cortical dynamics to enhance integration of relevant sensory input." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The climbing plants in India are listed in detail in this data note. This comprehensive list of climbers was compiled using more than 100 published and unpublished sources that span more than a century. It includes a total of 2,608 species representing 585 genera and 104 spermatophyte plant families. Each species listed in the dataset is categorised according to its degree of woodiness and climbing strategies. The dataset also includes information on The International Union for Conservation of Nature (IUCN) status of all climber species from India. The botanical nomenclature used in the data has been updated to reflect Angiosperm Phylogeny Group (APG) IV classification. Researchers who are conducting ecological, taxonomic, phylogenetic, and evolutionary studies on climbers will be particularly interested in this dataset.\n OUTPUT:\n " }, { "from": "agent", "value": "The climbing flora of India: A comprehensive checklist." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The aim of this study was to evaluate the preclinical results of 2 types of commercially available deproteinized bovine bone mineral (DBBM) when applied to alveolar bone defects in dogs.\n OUTPUT:\n " }, { "from": "agent", "value": "Evaluation of regeneration after the application of 2 types of deproteinized bovine bone mineral to alveolar bone defects in adult dogs." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This study aimed to investigate the safety of COVID-19 vaccination in patients with epilepsy (PWE) and their willingness to undergo vaccination.\n OUTPUT:\n " }, { "from": "agent", "value": "Experiences investigation for COVID-19 vaccination in patients with epilepsy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Liquid-liquid phase separation (LLPS) has emerged as an important phenomenon associated with formation of membraneless organelles. Recently, LLPS has been shown to act as nucleation centers for disease-associated protein aggregation and amyloid fibril formation. Phase-separated α-synuclein droplets gradually rigidify during the course of protein aggregation, and it is very challenging to understand the biomolecular interactions that lead to liquid-like to solid-like transition using conventional ensemble measurements. Here, we describe a spectrally-resolved fluorescence microscopy based Förster resonance energy transfer (FRET) imaging to probe interactions of α-synuclein in individual droplets during LLPS-mediated aggregation. By acquiring entire emission spectral profiles of individual droplets upon sequential excitation of acceptors and donors therein, this technique allows for the quantification of sensitized emission proportional to the extent of FRET, which enables interrogation of the evolution of local interactions of donor-/acceptor-labeled α-synuclein molecules within each droplet. The present study on single droplets is not only an important development for studying LLPS but can also be used to investigate self-assembly or aggregation in biomolecular systems and soft materials.\n OUTPUT:\n " }, { "from": "agent", "value": "Spectrally Resolved FRET Microscopy of α-Synuclein Phase-Separated Liquid Droplets." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Until recently the number of alleles of the nonclassical HLA class I gene HLA-E documented in the IPD-IMGT/HLA Database was small and as a result, the gene was often not considered to be notably polymorphic. Here, we describe our work in identifying and submitting 86 novel HLA-E alleles after full-gene single-molecule real-time (SMRT) DNA sequencing of 6227 DNA samples. These samples were comprised of 2468 patients undergoing hematopoietic cell transplantation and 3759 unrelated potential donors. A total of 111 unique HLA-E alleles were detected in this cohort. The majority of novel alleles (79.1%) contained polymorphisms in intronic regions, highlighting the significant undiscovered variation present in the noncoding regions of the HLA-E gene.\n OUTPUT:\n " }, { "from": "agent", "value": "86 novel HLA-E alleles discovered through full-gene sequencing of 6227 hematopoietic cell transplant patients and unrelated donors." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Disaster and space environments are similar in that they are closed environment, with limited lifelines. Here, we examined the similarity between disaster food and space food, to explore interactive problem-solving of food support for disaster and space environments. The Japan Disaster Food Certification Standards (Japan Disaster Food Society) and the Japanese Space Food Certification Standards (Japan Aerospace Exploration Agency) requirements and certified products, which were posted on the websites as of June 16, 2021, were compared. Certified products were classified into \"staple foods,\" \"main and/or side dishes,\" \"milk and dairy products,\" \"fruits,\" \"confectionery and favorite beverages,\" \"condiments,\" \"dietary supplements,\" and \"sets.\" Certification standards involved six items for Japan Disaster Food and eight items for Japanese Space Food. Most standards were similar. Concretely, both standards demanded room temperature storage, tough packaging and hygiene management in facilities. Both emphasized habitual food and easy eating. However, the best-by date was ≥6 mo for Japan Disaster Food, but ≥1.5 y for Japanese Space Food. In addition, Japanese Space Food required noted nutritious, food hygienic, eatable in space, cookable by specific equipment, endurable pressure by launch, and domestically produced food. There were 171 and 47 products of Japan Disaster Food and Japanese Space Food, respectively. Staple foods (pregelatinized rice, etc.) and main and/or side dishes were commonest among Japan Disaster Foods and Japanese Space Foods, respectively. It is possible to utilize of Space Food as Disaster Food, but there are some issues that must be cleared before \"utilization of Disaster Food as Space Food.\"\n OUTPUT:\n " }, { "from": "agent", "value": "Similarities between Disaster Food and Space Food." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Despite recent research associating social class with subjective well-being (SWB), the relationship between the two, manifested through victim justice sensitivity and envy, has not been properly investigated. Guided by social comparison and social cognitive tendency theories, we explored the direct and indirect relationships between social class and SWB among Chinese undergraduate students. This study employed a cross-sectional, questionnaire-based research design. 1,405 undergraduate students completed questionnaires regarding subjective social class, victim justice sensitivity, envy, and SWB. The results showed that social class was positively related to SWB and negatively associated with victim justice sensitivity and envy. Victim justice sensitivity was negatively related to SWB, victim justice sensitivity was positively related to envy, and envy was negatively associated with SWB. Social class correlated with SWB through three paths: the mediating role of victim justice sensitivity, the mediating role of envy, and the serial mediating roles of victim justice sensitivity and envy. The results indicate that social class could contribute to college students' SWB through the mechanisms of victim justice sensitivity and envy. This study advances the understanding of how the relationship between social class and college students' SWB operates. Furthermore, the findings will facilitate the promotion of college students' SWB.\n OUTPUT:\n " }, { "from": "agent", "value": "The relationship between social class and subjective well-being: A serial mediation model." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Recessive mutations in PRKN, PARK7, and PINK1 are established causes of early-onset Parkinson's disease (EOPD). Previous studies have interrogated the role of heterozygous variants in these genes but mainly focused on rare (minor allele frequency [MAF] &lt;1%) damaging variants or established mutations. Here, we assessed heterozygous private PRKN, PARK7 and PINK1 variants in PD risk in four large-scale PD case-control datasets by performing gene-wise burden analyses using sequencing data totaling 5,829 PD cases and 7,221 controls, and summary allele counts from 9,501 PD cases and 48,207 controls. Results showed no significant burden in all three genes after meta-analyses. Burden in EOPD (age at onset &lt;50 years) and late-onset PD (≥50 years) remained nonsignificant. In summary, we found no evidence to support the association of the excess burden of heterozygous private variants in PRKN, PARK7, and PINK1 with PD risk in the European population. Larger, more diverse cohorts are needed to accurately determine their role in PD.\n OUTPUT:\n " }, { "from": "agent", "value": "Gene-based burden analysis of damaging private variants in PRKN, PARK7 and PINK1 in Parkinson's disease cohorts of European descent." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Protein misfolding and self-assembling into amyloid structures are associated with a number of diseases. Characterization of protein amyloid formation reactions is a challenging task as transient populations of multiple species are involved. Here we outline a method for identification and characterization of the individual soluble states during protein amyloid formation. The method combines NMR translational diffusion measurements with multilinear data analysis.\n OUTPUT:\n " }, { "from": "agent", "value": "Identification of Distinct Soluble States During Fibril Formation Using Multilinear Analysis of NMR Diffusion Data." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Kawasaki disease is a systemic vasculitis, especially of the coronary arteries, affecting children. Despite extensive research, much is still unknown about the principal driver behind the amplified inflammatory response. We propose mitochondria may play a critical role. Mitochondria serve as a central hub, influencing energy generation, cell proliferation, and bioenergetics. Regulation of these biological processes, however, comes at a price. Release of mitochondrial DNA into the cytoplasm acts as damage-associated molecular patterns, initiating the development of inflammation. As a source of reactive oxygen species, they facilitate activation of the NLRP3 inflammasome. Kawasaki disease involves many of these inflammatory pathways. Progressive mitochondrial dysfunction alters the activity of immune cells and may play a role in the pathogenesis of Kawasaki disease. Because they contain their own genome, mitochondria are susceptible to mutation which can propagate their dysfunction and immunostimulatory potential. Population-specific variants in mitochondrial DNA have also been linked to racial disparities in disease risk and treatment response. Our objective is to critically examine the current literature of mitochondria's role in coordinating proinflammatory signaling pathways, focusing on potential mitochondrial dysfunction in Kawasaki disease. No association between impaired mitochondrial function and Kawasaki disease exists, but we suggest a relationship between the two. We hypothesize a framework of mitochondrial determinants that may contribute to ethnic/racial disparities in the progression of Kawasaki disease.\n OUTPUT:\n " }, { "from": "agent", "value": "The role of mitochondria in the pathogenesis of Kawasaki disease." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Tumours utilise tryptophan (Trp) and its metabolites to promote their growth and evade host defences. They recruit Trp through up-regulation of Trp transporters, and up-regulate key enzymes of Trp degradation and down-regulate others. Thus, Trp 2,3-dioxygenase (TDO2), indoleamine 2,3-dioxygenase 1 (IDO1), IDO2, N'-formylkynurenine formamidase (FAMID) and Kyn aminotransferase 1 (KAT1) are all up-regulated in many cancer types, whereas Kyn monooxygenase (KMO), kynureninase (KYNU), 2-amino-3-carboxymuconic acid-6-semialdehyde decarboxylase (ACMSD) and quinolinate phosphoribosyltransferase (QPRT) are up-regulated in a few, but down-regulated in many, cancers. This results in accumulation of the aryl hydrocarbon receptor (AhR) ligand kynurenic acid and in depriving the host of NAD+ by blocking its synthesis from quinolinic acid. The host loses more NAD+ by up-regulation of the NAD+-consuming poly (ADP-ribose) polymerases (PARPs) and the protein acetylaters SIRTs. The nicotinamide arising from PARP and SIRT activation can be recycled in tumours to NAD+ by the up-regulated key enzymes of the salvage pathway. Up-regulation of the Trp transporters SLC1A5 and SLC7A5 is associated mostly with that of TDO2 = FAMID &gt; KAT1 &gt; IDO2 &gt; IDO1. Tumours down-regulate enzymes of serotonin synthesis, thereby removing competition for Trp from the serotonin pathway. Strategies for combating tumoral immune escape could involve inhibition of Trp transport into tumours, inhibition of TDO and IDOs, inhibition of FAMID, inhibition of KAT and KYNU, inhibition of NMPRT and NMNAT, inhibition of the AhR, IL-4I1, PARPs and SIRTs, and by decreasing plasma free Trp availability to tumours by albumin infusion or antilipolytic agents and inhibition of glucocorticoid induction of TDO by glucocorticoid antagonism.\n OUTPUT:\n " }, { "from": "agent", "value": "Tryptophan metabolism and disposition in cancer biology and immunotherapy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Most pediatric COVID-19 cases are asymptomatic; however, a small number of children are diagnosed with multisystem inflammatory syndrome in children (MIS-C), a rare but severe condition that is associated with SARS-CoV-2 infection. Persistent symptoms of COVID-19 illness in children diagnosed with/without MIS-C is largely unknown. A retrospective EHR review of patients with COVID-19 illness from one pediatric healthcare system to assess the presence of acute (&lt;30 days) and chronic (≥30, 60-120, and &gt;120 days) long-term COVID symptoms was conducted. Patients/caregivers completed a follow-up survey from March 2021 to January 2022 to assess the presence of long COVID. Results showed that non-MIS-C children (\n OUTPUT:\n " }, { "from": "agent", "value": "Comparison of Long-Term Complications of COVID-19 Illness among a Diverse Sample of Children by MIS-C Status." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Immunotherapy for cancer that aims to promote T cell anti-tumor activity has changed current clinical practice, where some previously lethal cancers have now become treatable. However, clinical trials with low response rates have been disappointing for pancreatic ductal adenocarcinoma (PDAC). One suggested explanation is the accumulation of dominantly immunosuppressive tumor-associated macrophages and myeloid-derived suppressor cells in the tumor microenvironment (TME). Using retrospectively collected tumor specimens and transcriptomic data from PDAC, we demonstrate that expression of the scavenger receptor MARCO correlates with poor prognosis and a lymphocyte-excluding tumor phenotype. PDAC cell lines produce IL-10 and induce high expression of MARCO in myeloid cells, and this was further enhanced during hypoxic conditions. These myeloid cells suppressed effector T and natural killer (NK) cells and blocked NK cell tumor infiltration and tumor killing in a PDAC 3D-spheroid model. Anti-human MARCO (anti-hMARCO) antibody targeting triggered the repolarization of tumor-associated macrophages and activated the inflammasome machinery, resulting in IL-18 production. This in turn enhanced T cell and NK cell functions. The targeting of MARCO thus remodels the TME and represents a rational approach to make immunotherapy more efficient in PDAC patients.\n OUTPUT:\n " }, { "from": "agent", "value": "Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: BACKGROUND : Wilson disease (WD) is an autosomal recessive disorder caused by mutation in the Adenosine Triphosphate 7B (ATP7B) gene. The spectrum of ATP7B mutation varies in different populations. The objective of this study was to identify the mutation in exon 8 and exon 14 of ATP7B gene in Bangladeshi children clinically diagnosed as WD. We also aimed to explore the phenotypic presentation.\n OUTPUT:\n " }, { "from": "agent", "value": "Mutational analysis of exon 8 and exon 14 of ATP7B gene in Bangladeshi children with Wilson disease." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Alopecia Areata (AA) is a chronic condition which has been associated with poor quality of life and mood status disturbances. The aim of this study is to compare the sleep quality between AA patients and controls, and to analyze the impact of poor sleep quality on patients with AA regarding mood status disturbances, quality of life and sexuality. A cross-sectional study including patients suffering from mild-to-severe AA and sex- and age-matched healthy controls was performed. Socio-demographic and clinical variables, sleep quality, quality of life, sexual disfunction, anxiety, depression and personality were collected using validated questionnaires. A total of 120 participants (60 patients and 60 controls) were included. Patients with AA showed worse sleep scores than controls (\n OUTPUT:\n " }, { "from": "agent", "value": "The Impact of Sleep Quality on Mood Status and Quality of Life in Patients with Alopecia Areata: A Comparative Study." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Endometrial receptivity is essential for successful pregnancy, and its impairment is a major cause of embryo-implantation failure. MicroRNAs (miRNAs) that regulate epigenetic modifications have been associated with endometrial receptivity. However, the molecular mechanisms whereby miRNAs regulate endometrial receptivity remain unclear. Therefore, we investigated whether miR-182 and its potential targets influence trophoblast cell attachment. miR-182 was expressed at lower levels in the secretory phase than in the proliferative phase of endometrium tissues from fertile donors. However, miR-182 expression was upregulated during the secretory phase in infertile women. Transfecting a synthetic miR-182-5p mimic decreased spheroid attachment of human JAr choriocarcinoma cells and E-cadherin expression (which is important for endometrial receptivity). miR-182-5p also downregulated N-Myc downstream regulated 1 (NDRG1), which was studied further. NDRG1 was upregulated in the secretory phase of the endometrium tissues and induced E-cadherin expression through the nuclear factor-κΒ (NF-κΒ)/zinc finger E-box binding homeobox 1 (ZEB1) signaling pathway. NDRG1-overexpressing or -depleted cells showed altered attachment rates of JAr spheroids. Collectively, our findings indicate that miR-182-5p-mediated NDRG1 downregulation impaired embryo implantation by upregulating the NF-κΒ/ZEB1/E-cadherin pathway. Hence, miR-182-5p is a potential biomarker for negative selection in endometrial receptivity and a therapeutic target for successful embryo implantation.\n OUTPUT:\n " }, { "from": "agent", "value": "The miR-182-5p/NDRG1 Axis Controls Endometrial Receptivity through the NF-κB/ZEB1/E-Cadherin Pathway." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The purpose of this investigation was to determine ¹H-NMR profiling and antioxidant activity of the most common types of honey, namely, citrus honey (HC1) (\n OUTPUT:\n " }, { "from": "agent", "value": "¹H-NMR Metabolic Profiling, Antioxidant Activity, and Docking Study of Common Medicinal Plant-Derived Honey." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Online platforms play a relevant role in the creation and diffusion of false or misleading news. Concerningly, the COVID-19 pandemic is shaping a communication network which reflects the emergence of collective attention towards a topic that rapidly gained universal interest. Here, we characterize the dynamics of this network on Twitter, analysing how unreliable content distributes among its users. We find that a minority of accounts is responsible for the majority of the misinformation circulating online, and identify two categories of users: a few active ones, playing the role of 'creators', and a majority playing the role of 'consumers'. The relative proportion of these groups (approx. 14% creators-86% consumers) appears stable over time: consumers are mostly exposed to the opinions of a vocal minority of creators (which are the origin of 82% of fake content in our data), that could be mistakenly understood as representative of the majority of users. The corresponding pressure from a perceived majority is identified as a potential driver of the ongoing COVID-19 infodemic.\n OUTPUT:\n " }, { "from": "agent", "value": "The voice of few, the opinions of many: evidence of social biases in Twitter COVID-19 fake news sharing." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Glioblastoma (GBM) is the most common form of malignant primary brain tumor with a dismal prognosis. Currently, the standard treatments for GBM rarely achieve satisfactory results, which means that current treatments are not individualized and precise enough. In this study, a multiomics-based GBM classification was established and three subclasses (GPA, GPB, and GPC) were identified, which have different molecular features both in bulk samples and at single-cell resolution. A robust GBM poor prognostic signature (GPS) score model was then developed using machine learning method, manifesting an excellent ability to predict the survival of GBM. NVP-BEZ235, GDC-0980, dasatinib and XL765 were ultimately identified to have subclass-specific efficacy targeting patients with a high risk of poor prognosis. Furthermore, the GBM classification and GPS score model could be considered as potential biomarkers for immunotherapy response. In summary, an integrative genomic analysis was conducted to advance individual-based therapies in GBM.\n OUTPUT:\n " }, { "from": "agent", "value": "Integrative genomic analysis facilitates precision strategies for glioblastoma treatment." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: This paper presents a formulation of a preview optimal control strategy for a half-car model equipped with active aerodynamic surfaces. The designed control strategy consists of two parts: a feed-forward controller to deal with the future road disturbances and a feedback controller to deal with tracking error. An anti-jerk functionality is employed in the design of preview control strategy that can reliably reduce the jerk of control inputs to improve the performance of active aerodynamic surfaces and reduce vehicle body jerk to enhance the ride comfort without degrading road holding capability. The proposed control scheme determines proactive control action against oncoming potential road disturbances to mitigate the effect of deterministically known road disturbances. The performance of proposed anti-jerk optimal control strategy is compared with that of optimal control without considering jerk. Simulation results considering frequency and time domain characteristics are carried out using MATLAB to demonstrate the effectiveness of the proposed scheme. The frequency domain characteristics are discussed only for the roll inputs, while time domain characteristics are discussed for the corresponding ground velocity inputs of bump and asphalt road, respectively. The results show that using anti-jerk optimal preview control strategy improves the performance of vehicle dynamics by reducing jerk of aerodynamic surfaces and vehicle body jerk simultaneously.\n OUTPUT:\n " }, { "from": "agent", "value": "Performance Improvement of a Vehicle Equipped with Active Aerodynamic Surfaces Using Anti-Jerk Preview Control Strategy." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Predator-prey interactions shape ecosystem stability and are influenced by changes in ecosystem productivity. However, because multiple biotic and abiotic drivers shape the trophic responses of predators to productivity, we often observe patterns, but not mechanisms, by which productivity drives food web structure. One way to capture mechanisms shaping trophic responses is to quantify trophic interactions among multiple trophic groups and by using complementary metrics of trophic ecology. In this study, we combine two diet-tracing methods: diet DNA and stable isotopes, for two trophic groups (top predators and intermediate predators) in both low- and high-productivity habitats to elucidate where in the food chain trophic structure shifts in response to changes in underlying ecosystem productivity. We demonstrate that while top predators show increases in isotopic trophic position (<i>δ</i>¹⁵N) with productivity, neither their isotopic niche size nor their DNA diet composition changes. Conversely, intermediate predators show clear turnover in DNA diet composition towards a more predatory prey base in high-productivity habitats. Taking this multi-trophic approach highlights how predator identity shapes responses in predator-prey interactions across environments with different underlying productivity, building predictive power for understanding the outcomes of ongoing anthropogenic change.\n OUTPUT:\n " }, { "from": "agent", "value": "Changes in invertebrate food web structure between high- and low-productivity environments are driven by intermediate but not top-predator diet shifts." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Aims The aim of this project was to provide an ambulatory pathway for diagnosis and management of patients with suspected Pulmonary Embolism (PE) with \"low-risk\" features. Methods A structured algorithm for the management of suspected PE was designed and implemented in April 2021. This involved the development of local guidelines to identify those \"low-risk\" patients with suspected PE, through the use of modified sPESI and Hestia criteria. This pathway was audited monthly to establish effect on admission and hospital length of stay. Results 51 CT PAs were performed by the Emergency Department in April 2021. Total number of CT confirmed PEs in April was 7(11%). 12 \"low-risk\" patients with suspected PE were identified and placed on the \"Ambulatory Suspected Pulmonary Embolism Pathway\". One (8.3%) patient on this pathway had a confirmed PE. Patients placed on this pathway spent significantly less time in the Emergency Department and in hospital with greater satisfaction by physicians using this pathway. Conclusion This pathway has succeeded in significantly decreasing length of stay both in the ED and in hospital for patients with suspected and confirmed PE.\n OUTPUT:\n " }, { "from": "agent", "value": "An Ambulatory Pathway for the Investigation of Patients with Suspected Pulmonary Embolism." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Mitochondrial DNA changes can contribute to both an increased and decreased likelihood of cancer. This process is complex and not fully understood. Polymorphisms and mutations, especially those of the missense type, can affect mitochondrial functions, particularly if the conservative domain of the protein is concerned. This study aimed to identify the possible relationships between brain gliomas and the occurrence of specific mitochondrial DNA polymorphisms and mutations in respiratory complexes III, IV and V. The investigated material included blood and tumour material collected from 30 Caucasian patients diagnosed with WHO grade II, III or IV glioma. The mitochondrial genetic variants were investigated across the mitochondrial genome using next-generation sequencing (MiSeq/FGx system-Illumina). The study investigated, in silico, the effects of missense mutations on the biochemical properties, structure and functioning of the encoded protein, as well as their potential harmfulness. The A14793G (MTCYB), A15758G, (MT-CYB), A15218G (MT-CYB), G7444A (MT-CO1) polymorphisms, and the T15663C (MT-CYB) and G8959A (ATP6) mutations were assessed in silico as harmful alterations that could be involved in oncogenesis. The G8959A (E145K) ATP6 missense mutation has not been described in the literature so far. In light of these results, further research into the role of mtDNA changes in brain tumours should be conducted.\n OUTPUT:\n " }, { "from": "agent", "value": "Mitochondrial DNA Changes in Genes of Respiratory Complexes III, IV and V Could Be Related to Brain Tumours in Humans." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Asthma is a chronic disease of the airways characterized by inflammation, tightened muscles, and thickened airway walls leading to symptoms such as shortness of breath, chest tightness, and cough in patients. The increased risk of asthma in children of asthmatics parents supports the existence of genetic factors involved in the pathogenesis of this disease. Genome-wide association studies have discovered several single nucleotide polymorphisms associated with asthma. These polymorphisms occur within several genes and can contribute to different asthma phenotypes, affect disease severity, and clinical response to different therapies. The complexity in the etiology of asthma also results from interactions between environmental and genetic factors. Environmental exposures have been shown to increase the prevalence of asthma in individuals who are genetically susceptible. This review summarizes what is currently known about the genetics of asthma in relation to risk, response to common treatments, and gene-environmental interactions.\n OUTPUT:\n " }, { "from": "agent", "value": "The Genetic Factors of the Airway Epithelium Associated with the Pathology of Asthma." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Noninvasive single-photon emission computed tomography (SPECT) imaging with [\n OUTPUT:\n " }, { "from": "agent", "value": "Longitudinal MicroSPECT Imaging of Systemic Sclerosis Model Mice with [" } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: African swine fever (ASF) is the most dangerous pig disease, and causes enormous economic losses in the global pig industry. However, the mechanisms of ASF virus (ASFV) infection remains largely unclear. Hence, this study investigated the host response mechanisms to ASFV infection. We analyzed the differentially expressed proteins (DEPs) between serum samples from ASFV-infected and uninfected pigs using quantitative proteomics. Setting the \n OUTPUT:\n " }, { "from": "agent", "value": "African swine fever virus infection activates inflammatory responses through downregulation of the anti-inflammatory molecule C1QTNF3." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Nucleoplasty and neuroplasty are often performed in patients with refractory lower back pain when conservative treatment is ineffective. Lumbar spinal stenosis (LSS) is caused by multiple factors; in some cases, a single procedure of nucleoplasty or neuroplasty alone does not provide sufficient treatment effect.\n OUTPUT:\n " }, { "from": "agent", "value": "Comparison of the Effect of Balloon Catheter vs Nucleoplasty vs Balloon Catheter and Nucleoplasty in Patients With Lumbar Spinal Stenosis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Addenbrooke's cognitive examination (ACE) is a cognitive screening tool that has developed through three stages: ACE, ACE-Revised (ACE-R), and ACE-Ⅲ. In addition, mini-Addenbrooke's Cognitive Examination (M-ACE) and ACE mobile are the additional versions that is derived from ACE-III. ACE and its related versions show better performance than Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in detecting mild cognitive impairment in different neurological disorders. It has been translated into numerous languages, including Chinese. Through reviewing the history, validity, and comparison with other cognitive tests of Chinese versions of ACE, it aims to facilitate the clinical and scientific use, further development, improvement, and validation of Chinese versions of ACE in various neurological disorders and ultimately promote early identification and management of cognitive impairment in China.\n OUTPUT:\n " }, { "from": "agent", "value": "Utility of Chinese Versions of Addenbrooke's Cognitive Examination: A Narrative Review." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Cortical stimulation \n OUTPUT:\n " }, { "from": "agent", "value": "Artifact propagation in subdural cortical electrostimulation: Characterization and modeling." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Salt stress during pre-harvest limits the shelf life and post-harvest quality of produce; however, silicon nutrition can mitigate salt stress in plants. Thus, we evaluated the effects of salinity and fertilization with Si, in pre-harvest, on the morpho-physiological characteristics of onion bulbs during shelf life. The experiment was set up in randomized complete blocks, with treatments arranged in split-split plots. The plots had four levels of electrical conductivity of irrigation water (0.65, 1.7, 2.8, and 4.1 dS m\n OUTPUT:\n " }, { "from": "agent", "value": "Effect of Salinity and Silicon Doses on Onion Post-Harvest Quality and Shelf Life." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: In aging, the brain is more vulnerable to injury and neurodegenerative disease, but the mechanisms responsible are largely unknown. Evidence now suggests that neuroinflammation, mediated by resident brain astrocyte and microglia populations, are key players in the generation of inflammatory responses and may influence both age related processes and the initiation/progression of neurodegeneration. Consequently, targeting these cell types individually and collectively may aid in the development of novel disease-modifying therapies. We have optimized and characterized a protocol for the effective sequential isolation of both microglia and astrocytes from the adult mouse brain in young and aged mice. We demonstrate a technique for the sequential isolation of these immune cells by using magnetic beads technology, optimized to increase yield and limit potential artifacts in downstream transcriptomic applications, including RNA-sequencing pipelines. This technique is versatile, cost-effective, and reliable for the study of responses within the same biological context, simultaneously being advantageous in reducing mice numbers required to assess cellular responses in normal and age-related pathological conditions.\n OUTPUT:\n " }, { "from": "agent", "value": "Sequential Isolation of Microglia and Astrocytes from Young and Aged Adult Mouse Brains for Downstream Transcriptomic Analysis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The response time is an important parameter for thermopiles sensors, which reflects the response speed of the device. The accurate measurement of response time is extremely important to evaluate device characteristics for using them in suitable scenarios. In this work, to accurately measure the response time of thermopile sensors, an Al microheater is integrated in a MEMS thermopile as an in situ heat source. Compared with the traditional chopper measurement method for response time, this approach avoids mechanical delay induced by chopper blades. Accordingly, based on this approach, the response time of the device is measured to be 6.9 ms, while that is 12.7 ms when a chopping system is used, demonstrating that an error of at least 5.8 ms is avoided. Such an approach is quite simple to realize and provides a novel route to accurately measure the response time.\n OUTPUT:\n " }, { "from": "agent", "value": "A Highly Accurate Method for Measuring Response Time of MEMS Thermopiles." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Tinnitus is an intrusive and chronic illness affecting a significant portion of the population, decreasing affected individuals' quality of life and socioeconomic functioning. Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuromodulatory method utilizing weak electrical currents to elicit short and long-term central nervous system changes. Several studies have proven its effect on tinnitus. We aimed to broaden the knowledge and provide data on the effect and its retention.\n OUTPUT:\n " }, { "from": "agent", "value": "Long-term effect of transcranial direct current stimulation in the treatment of chronic tinnitus: A randomized, placebo-controlled trial." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Although productive progress has been made in colorectal cancer (CRC) researchs, CRC is the second most frequent type of malignancy and the major cause of cancer-related death among gastrointestinal cancers. As angiogenesis constitutes an important point in the control of CRC progression and metastasis, understanding the key signaling pathways that regulate CRC angiogenesis is critical in elucidating ways to inhibit CRC. Herein, we comprehensively summarized the angiogenesis-related pathways of CRC, including vascular endothelial growth factor (VEGF), nuclear factor-kappa B (NF-κB), Janus kinase (JAK)/signal transducer and activator of transcription (STAT), Wingless and int-1 (Wnt), and Notch signaling pathways. We divided the factors influencing the specific pathway into promoters and inhibitors. Among these, some drugs or natural compounds that have antiangiogenic effects were emphasized. Furthermore, the interactions of these pathways in angiogenesis were discussed. The current review provides a comprehensive overview of the key signaling pathways that are involved in the angiogenesis of CRC and contributes to the new anti-angiogenic strategies for CRC.\n OUTPUT:\n " }, { "from": "agent", "value": "Classical Angiogenic Signaling Pathways and Novel Anti-Angiogenic Strategies for Colorectal Cancer." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Type 2 diabetes is a lifestyle-related disease that affects people worldwide and is especially prevalent in the elderly. Many elderly people with diabetes also complain of dry skin; however, the relationship between aging and dry skin in type 2 diabetes is unknown. The purpose of this study was to examine the interaction between aging and dry skin using the specific pathogen-free KK-Ay/TaJcl type 2 diabetes mouse model. Skin dryness in this model increases with age and was evaluated at 10, 27, 40, and 50 weeks. We observed increased mast cell expression, increased histamine and matrix metalloproteinase-1 levels, and decreased collagen expression in the skin of aging KK-Ay/TaJcl mice. In addition, the increased expression of angiopoietin 2, interleukin-6, tumor necrosis factor-α, and endostatin in the blood indicated kidney damage in this model. Aging KK-Ay/TaJcl mice also showed fatty liver pathology, which led to increased reactive oxygen species in the blood and liver, as well as the increased expression of M1 macrophages in the liver. These results showed that dry skin is associated with skin, kidney, and liver interactions in an aging type 2 diabetes mouse model.\n OUTPUT:\n " }, { "from": "agent", "value": "Skin, Liver, and Kidney Interactions Contribute to Skin Dryness in Aging KK-Ay/Tajcl Mice." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Avian metapneumoviruses (aMPV subtypes A-D) are respiratory and reproductive pathogens of poultry. Since aMPV-A was initially reported in Mexico in 2014, there have been no additional reports of its detection in the country. Using nontargeted next-generation sequencing (NGS) of FTA card-spotted respiratory samples from commercial chickens in Mexico, seven full genome sequences of aMPV-A (lengths of 13,288-13,381 nucleotides) were de novo assembled. Additionally, complete coding sequences of genes N (\n OUTPUT:\n " }, { "from": "agent", "value": "Detection and Genome Sequence Analysis of Avian Metapneumovirus Subtype A Viruses Circulating in Commercial Chicken Flocks in Mexico." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: It is well known that many mineral deposits are related to hydrothermal processes, especially auriferous deposits. In this research paper, we show how to distinguish areas that have experienced hydrothermal activity, by construing airborne gamma-ray spectrometry data, especially potassium. An indirect application of aerial gamma-ray spectrometry technique is used to detect possible minerals deposits. In this region, an airborne gamma ray survey (K, eU and eTh) was carried out, based on irregular K, \"F\" parameter -, and Th-normalized of the K and eU anomalies. This work exhibits the mapping of hydrothermal regions possibly showing gold mineralization and the pointing out of new geological portions for this sequence, establishing prospective criteria for regional mineral exploration. We can suggest a new exploratory target, the area that is located next to Jabal Al-Ardiya (white colour on ternary map), which is characterized by high values of F-parameter, KD%, and K/eTh. Besides, enriched areas are found scattered in the north-eastern side of the study area. As result, the airborne gamma ray spectromertic data, might be used for estimation of prospective Gold Ore zones associated with the potassium alteration.\"\n OUTPUT:\n " }, { "from": "agent", "value": "Using of airborne gamma-ray spectrometric data to the exposure of potassic alteration -recognition of alteration relates to gold mineralization." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third highly pathogenic human coronavirus and is rapidly transmitted by infected individuals regardless of their symptoms. During the COVID-19 pandemic, owing to the dearth of skilled healthcare workers (HCWs) to collect samples for early diagnosis, self-collection emerged as a viable alternative. To evaluate the reliability of self-collection, we compared the virus detection rate using 3990 self-collected swabs and HCW-collected swabs, procured from the same individuals and collected immediately after the self-collection. The results of multiplex reverse-transcription quantitative polymerase chain reaction revealed that the viral load in the HCW-collected swabs was marginally (18.4-28.8 times) higher than that in self-collected swabs. Self-collection showed no significant difference in sensitivity and specificity from HCW-collection (κ = 0.87, McNemar's test; \n OUTPUT:\n " }, { "from": "agent", "value": "Performance Analysis of Self-Collected Nasal and Oral Swabs for Detection of SARS-CoV-2." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Alternative splicing (AS) is an important post-transcriptional mechanism promoting the diversity of transcripts and proteins to regulate various life processes in eukaryotes. Sclerotinia stem rot is a major disease of \n OUTPUT:\n " }, { "from": "agent", "value": "Alternative splicing reprogramming in fungal pathogen " } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: The tapetum is a specialized layer of cells within the anther, adjacent to the sporogenous tissue. During its short life, it provides nutrients, molecules and materials to the pollen mother cells and microsporocytes, being essential during callose degradation and pollen wall formation. The interaction between the tapetum and sporogenous cells in Solanum lycopersicum (tomato) plants, despite its importance for breeding purposes, is poorly understood. To investigate this process, gene editing was used to generate loss-of-function mutants that showed the complete and specific absence of tapetal cells. These plants were obtained targeting the previously uncharacterized Solyc03g097530 (SlTPD1) gene, essential for tapetum specification in tomato plants. In the absence of tapetum, sporogenous cells developed and callose deposition was observed. However, sporocytes failed to undergo the process of meiosis and finally degenerated, leading to male sterility. Transcriptomic analysis conducted in mutant anthers lacking tapetum revealed the downregulation of a set of genes related to redox homeostasis. Indeed, mutant anthers showed a reduction in the accumulation of reactive oxygen species (ROS) at early stages and altered activity of ROS-scavenging enzymes. The results obtained highlight the importance of the tapetal tissue in maintaining redox homeostasis during male gametogenesis in tomato plants.\n OUTPUT:\n " }, { "from": "agent", "value": "The tapetal tissue is essential for the maintenance of redox homeostasis during microgametogenesis in tomato." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Neoadjuvant systemic therapy (NST) for triple-negative breast cancer and HER2-positive breast cancer yields a pathological complete response in approximately 60% of patients. A pathological complete response to NST predicts an excellent prognosis and can be accurately determined by percutaneous image-guided vacuum-assisted core biopsy (VACB). We evaluated radiotherapy alone, without breast surgery, in patients with early-stage triple-negative breast cancer or HER2-positive breast cancer treated with NST who had an image-guided VACB-determined pathological complete response.\n OUTPUT:\n " }, { "from": "agent", "value": "Eliminating breast surgery for invasive breast cancer in exceptional responders to neoadjuvant systemic therapy: a multicentre, single-arm, phase 2 trial." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Wild type transthyretin-derived amyloid (ATTRwt) is the major component of non-hereditary transthyretin amyloidosis. Its accumulation in the heart of elderly patients is life threatening. A variety of genetic variants of transthyretin can lead to hereditary transthyretin amyloidosis, which shows different clinical symptoms, like age of onset and pattern of organ involvement. However, in the case of non-hereditary transthyretin amyloidosis ATTRwt fibril deposits are located primarily in heart tissue. In this structural study we analyzed ATTRwt amyloid fibrils from the heart of a patient with non-hereditary transthyretin amyloidosis. We present a 2.78 Å reconstructed density map of these ATTRwt fibrils using cryo electron microscopy and compare it with previously published V30M variants of ATTR fibrils extracted from heart and eye of different patients. All structures show a remarkably similar spearhead like shape in their cross section, formed by the same N- and C-terminal fragments of transthyretin with some minor differences. This demonstrates common features for ATTR fibrils despite differences in mutations and patients.\n OUTPUT:\n " }, { "from": "agent", "value": "Cryo-EM structure of an ATTRwt amyloid fibril from systemic non-hereditary transthyretin amyloidosis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Adropin is a peptide encoded by the energy homeostasis-associated gene (\n OUTPUT:\n " }, { "from": "agent", "value": "Therapeutic Benefits of Adropin in Aged Mice After Transient Ischemic Stroke via Reduction of Blood-Brain Barrier Damage." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Diabetes is associated with several complications, including neuropathic pain, which is difficult to manage with currently available drugs. Descending noradrenergic neurons possess antinociceptive activity; however, their involvement in diabetic neuropathic pain remains to be explored.\n OUTPUT:\n " }, { "from": "agent", "value": "Guanfacine Normalizes the Overexpression of Presynaptic α-2A Adrenoceptor Signaling and Ameliorates Neuropathic Pain in a Chronic Animal Model of Type 1 Diabetes." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Epithelial-mesenchymal transition is one of the main mechanisms for tumor progression and metastasis. Transcription factors such as TWIST1 are key regulators of the epithelial-mesenchymal transition and are regarded as potential therapeutic targets for the treatment of cancer. The purpose of this study was to examine TWIST1 as a possible epithelial-mesenchymal transition-related prognostic biomarker in oral epithelial dysplasia and oral tongue squamous cell carcinomas, as well as the biological behavior of TWIST1-silencing in oral tongue squamous cell carcinomas cell lines.\n OUTPUT:\n " }, { "from": "agent", "value": "TWIST1 regulates proliferation, migration, and invasion and is a prognostic marker for oral tongue squamous cell carcinoma." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Obesity is a pathology whose incidence is increasing throughout the world. There are many pathologies associated with obesity. In recent years, the influence of the microbiota on both health and pathological states has been known. There is growing information related to changes in the microbiome and obesity, as well as its associated pathologies. Changes associated with age, exercise, and weight changes have been described. In addition, metabolic changes associated with the microbiota, bariatric surgery, and fecal matter transplantation are described. In this review, we summarize the biology and physiology of microbiota in obese patients, its role in the pathophysiology of several disorders associated, and the emerging therapeutic applications of prebiotics, probiotics, and fecal microbiota transplantation.\n OUTPUT:\n " }, { "from": "agent", "value": "Gut microbiota and obesity: New insights." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Extracellular vesicles (EVs) are small packages that are released by almost all types of cells. While the role of EVs in pathogenesis of certain diseases such as cancer is well established, EVs role in ocular health and disease is still at early stages of investigation. Given the significant role of EVs in pathological development and progression of diseases such as cancer, EVs present a similar opportunity for investigation in ocular pathophysiology. Studies have shown the presence of EVs in fluids from the ocular environment have close links with ocular health and disease. Hence, the cargo carried in EVs from ocular fluids can be used for monitoring disease phenotypes or therapeutic outcomes in eye-related disorders. Furthermore, in recent times EVs have increasingly gained attention as therapeutics and drug-delivery vehicles for treatment of eye diseases. There is a close relationship between EVs and mitochondria functioning with mitochondria dysfunction leading to a significant number of ophthalmic disorders. This review discusses the current knowledge of EVs in visual systems with a special focus on eye diseases resulting from dysfunctional mitochondria.\n OUTPUT:\n " }, { "from": "agent", "value": "Role of extracellular vesicles in mitochondrial eye diseases." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: Leptospirosis is a zoonotic disease of global importance. The current vaccine provides serovar-specific and short-term immunity and does not prevent bacterial shedding in infected animals. Subunit vaccines based on surface proteins have shown to induce protection in an animal model. However, these proteins were tested with non-clinical adjuvants and induced low to moderate protective efficacy. We formulated a variable region of \n OUTPUT:\n " }, { "from": "agent", "value": "LigA formulated in AS04 or Montanide ISA720VG induced superior immune response compared to alum, which correlated to protective efficacy in a hamster model of leptospirosis." } ]

[ { "from": "human", "value": "Given an abstract of a biomedical paper, generate the title.\n INPUT: We present exact solutions of test particle orbits spiraling inward from the innermost stable circular orbit (ISCO) of a Kerr black hole. Our results are valid for any allowed value of the angular momentum a parameter of the Kerr metric. These solutions are of considerable physical interest. In particular, the radial four-velocity of these orbits is both remarkably simple and, with the radial coordinate scaled by its ISCO value, universal in form, otherwise completely independent of the black hole spin.\n OUTPUT:\n " }, { "from": "agent", "value": "Inspirals from the Innermost Stable Circular Orbit of Kerr Black Holes: Exact Solutions and Universal Radial Flow." } ]