recordId int64 | PMID int64 | title string | abstract string | labels int64 |
|---|---|---|---|---|
0 | 2,729,896 | Efficient computation of lod scores: genotype elimination, genotype redefinition, and hybrid maximum likelihood algorithms. | Calculation of multilocus lod scores presents challenging problems in numerical analysis, combinatories, programming, and genetics. It is possible to accelerate these computations by exploiting the simple pedigree structure of a CEPH-type pedigree consisting of a nuclear family plus all four grandparents. Lathrop et al... | 0 |
1 | 1,935,695 | The switch from larval to adult globin gene expression in Xenopus laevis is mediated by erythroid cells from distinct compartments. | The transition of hemoglobins during metamorphosis of Xenopus laevis involves replacement of the larval erythrocytes by adult ones, suggesting that the developmental control of this event depends upon the growth characteristics of the precursor cells. To identify the erythroid precursor cells and to investigate their d... | 0 |
2 | 19,810,439 | Postpartum mental illness: perspectives from an Arabian Gulf population. | There is growing awareness of the importance of mental health issues in the perinatal period in Western societies, but very little information is available from Muslim and Arab countries. Qualitative information gathered using focus group discussions of women of childbearing age is presented along with additional infor... | 0 |
3 | 9,238,028 | What initiates speciation in passion-vine butterflies? | Studies of the continuum between geographic races and species provide the clearest insights into the causes of speciation. Here we report on mate choice and hybrid viability experiments in a pair of warningly colored butterflies, Heliconius erato and Heliconius himera, that maintain their genetic integrity in the face ... | 0 |
4 | 11,023,715 | Eptastigmine restores the aged rat's normal cortical spectral power pattern. | We studied the ability of eptastigmine, a second-generation acetylcholinesterase inhibitor (AChEI), to reverse the age-related increase of electroencephalogram (EEG) mean cortical spectral power in slow-wave delta activity and decrease in fast-wave alpha and beta activity. The relative basal spectral power profile eval... | 0 |
5 | 6,607,727 | New findings in posterior amorphous corneal dystrophy. | Eight members of a family spanning five generations were found to have posterior amorphous corneal dystrophy. This rare abnormality was noted in both its centroperipheral and peripheral forms. The following five heretofore unrecognized features were noted: (1) hyperopia, (2) flattened corneal topography, (3) anterior i... | 0 |
6 | 6,736,367 | Computed tomography in congenital heart disease. | The CT results in defining anatomic and certain physiologic features in patients with congenital heart and great vessel anomalies were reviewed in 32 patients with a variety of congenital cardiac and aortic arch anomalies. Most of these cases (18 patients) were selected on the basis of angiocardiographic or echocardiog... | 0 |
7 | 15,631,204 | [Resistance to gentamicin, amikacin and ciprofloxacin among nosocomial isolates of klebsiella pneumoniae subspecie pneumoniae producing extended spectrum beta-lactamases]. | BACKGROUND: Klebsiella pneumoniae is a pathogenic bacterium frequently isolated from nosocomial samples, specially the subspecie pneunonlae, with extensive antibiolic resistance profiles, including third generation cepbhalosporiis, aminoglycosides and quinolones. This is specially true for those strains producing exte... | 0 |
8 | 16,342,261 | Transmission of migration propensity increases genetic divergence between populations. | The advent of molecular genetics has brought invaluable information, which is now routinely used by anthropologists in their attempt to reconstruct our demographic past. Since mitochondrial DNA loci are much more similar between populations than are Y-chromosome loci, it is suggested that women had a much higher migrat... | 0 |
9 | 7,533,121 | Persistent hepatitis C viremia after acute self-limiting posttransfusion hepatitis C. | Persistent viremia after clinical or subclinical hepatitis C virus (HCV) infection is believed to occur in patients with chronic hepatitis C, but little is known about the duration of HCV replication in patients with acute hepatitis who have recovered or the relation of HCV viremia with the kinetics of antibodies to HC... | 0 |
10 | 12,116,273 | Anticipation in migraine with affective psychosis. | Anticipation is the term given to the apparent occurrence of an inherited disorder at a progressively earlier age of onset in successive generations. A family of a mother and two children, a 17-year-old girl and a 13-year-old boy, all experienced migraine with affective psychosis. There is a strong genetic predispositi... | 0 |
11 | 9,069,538 | Prevalence and mechanism of resistance to 'third-generation' cephalosporins in clinically relevant isolates of Enterobacteriaceae from 43 hospitals in the UK, 1990-1991. | In a UK survey of the occurrence of extended spectrum beta-lactamases, 96 hospitals submitted a total of 3951 non-selected, non-duplicate isolates of Enterobacteriaceae from 100 patients in each hospital, 206 of these cultures being mixed and, therefore, discarded. These isolates were initially screened for strains lik... | 0 |
12 | 7,571,782 | [PTCA or alternative techniques? Balloon angioplasty remains dominant]. | The use of second generation devices like excimer laser, rotablator, directional atherectomy, and stents is increasing. It is noteworthy that they are used in most cases in combination with "balloon" dilatation. The application of these more expensive techniques requires more experience and skills than mere balloon dil... | 0 |
13 | 2,773,771 | Effect of the second-generation calcium channel blocking drug nisoldipine on diastolic left ventricular dysfunction in heart failure. | The effect of intravenous nisoldipine (0.12 microgram/kg/min) on diastolic left ventricular (LV) dysfunction was studied from simultaneous hemodynamic and radionuclide measurements in 12 patients with New York Heart Association class II to IV cardiac failure. The initial LV filling fraction was low, the peak LV filling... | 0 |
14 | 9,842,066 | The American Indian Holocaust: healing historical unresolved grief. | American Indians experienced massive losses of lives, land, and culture from European contact and colonization resulting in a long legacy of chronic trauma and unresolved grief across generations. This phenomenon, labeled historical unresolved grief, contributes to the current social pathology of high rates of suicide,... | 0 |
15 | 18,021,156 | A multigenerational cohort study of psychosis and suicide in a rural community: incidence rates and genetic founder effects. Preface. | null | 1 |
16 | 18,392,543 | Conceptions held by health professionals on violence against children and adolescents within the family. | The present study sought to understand the conceptions held by health professionals with regards to violence within the family against children and adolescents. Qualitative case-study methodology and techniques of participant observation, interviewing, and search in documents were used. Participants were staffed in a g... | 0 |
17 | 3,239,077 | The Gotland house: family relations through four generations in rural Sweden. | In discussing the opportunities for development in the local space, one should not go astray in theoretical speculations since development springs from the hearts of the people and their societies. In this story, we follow a family on an old farm on the Baltic island of Gotland through four generations--from Jaken, bor... | 0 |
18 | 8,798,156 | Activation of the mec-3 promoter in two classes of stereotyped lineages in Caenorhabditis elegans. | The mec-3 gene of Caenorhabditis elegans encodes a homeodomain protein and is expressed in one of two cells upon asymmetric cell division. As a result of asymmetric mec-3 expression, the two sister cells express different fates, so mec-3 is a likely target for the machinery that mediates asymmetric cell division. The u... | 0 |
19 | 17,912,637 | A decade of letrozole: FACE. | Third-generation nonsteroidal aromatase inhibitors (AIs), letrozole and anastrozole, are superior to tamoxifen as initial therapy for early breast cancer but have not been directly compared in a head-to-head adjuvant trial. Cumulative evidence suggests that AIs are not equivalent in terms of potency of estrogen suppres... | 0 |
20 | 7,570,276 | [Thrombocytopenia with absence of the radius in a 24-year-old woman]. | Thrombocytopenia with absent radius syndrome (TAR) is a rare disorder appearing at birth or soon after. The heredity pattern is autosomal recessive, although some patients in successive generations have been reported. A 24 year-old woman is presented who had moderate thrombocytopenia and shortened forearms due to lack ... | 0 |
21 | 335,323 | [The founding of the 1st County Hospital at Szekszárd and the 1st physician of the institution: Mihály Babits, great-grandfather of the poet]. | null | 0 |
22 | 21,779,316 | Sequence variants of the Phytophthora sojae RXLR effector Avr3a/5 are differentially recognized by Rps3a and Rps5 in soybean. | The perception of Phytophthora sojae avirulence (Avr) gene products by corresponding soybean resistance (Rps) gene products causes effector triggered immunity. Past studies have shown that the Avr3a and Avr5 genes of P. sojae are genetically linked, and the Avr3a gene encoding a secreted RXLR effector protein was recen... | 0 |
23 | 12,320,686 | [Turkish immigrants in Western Europe: with reference to the German case]. | "The export of surplus manpower to Western Europe has been an important feature of the Turkish employment policy since the 1960s....Professional education, set up in the receiving countries for foreign workers, has played a vital role on the employment opportunities. This is particularly the case of Germany, where the ... | 0 |
24 | 18,049,929 | Babies and toddlers in non-parental daycare can avoid stress and anxiety if they develop a lasting secondary attachment bond with one carer who is consistently accessible to them. | Babies and toddlers will have their attachment seeking response activated in the absence of the primary or a secondary attachment figure when they are in the presence of a stranger and in unfamiliar surroundings. Between the ages of about 6 months and 30 months, babies and toddlers can only terminate their attachment s... | 0 |
25 | 17,187,664 | Identification of potential CepR regulated genes using a cep box motif-based search of the Burkholderia cenocepacia genome. | BACKGROUND: The Burkholderia cenocepacia CepIR quorum sensing system has been shown to positively and negatively regulate genes involved in siderophore production, protease expression, motility, biofilm formation and virulence. In this study, two approaches were used to identify genes regulated by the CepIR quorum sen... | 0 |
26 | 17,763,547 | TMC125 (etravirine), a second generation non-nucleoside reverse transcriptase inhibitor. | null | 0 |
27 | 19,513,948 | GA-101, a third-generation, humanized and glyco-engineered anti-CD20 mAb for the treatment of B-cell lymphoid malignancies. | Glycart Biotechnology AG, Genentech Inc, F Hoffmann-La Roche Ltd, Biogen Idec Inc and Chugai Pharmaceutical Co Ltd are developing GA-101, a third-generation, humanized and glyco-engineered anti-CD20 IgG1 mAb, for the potential treatment of B-cell malignancies. Compared with classic type I CD20 antibodies (eg, rituximab... | 0 |
28 | 8,640,195 | Gametocytogenesis of Leucocytozoon caulleryi in in vitro culture: effect of human red blood cells on the development of second-generation merozoites. | For investigating development of second-generation merozoites of Leucocytozoon caulleryi into mature gametocytes, infected erythrocytes from chickens at 15 d after sporozoites inoculation were cultured in RPMI-1640 modified medium supplemented with 10% horse serum and 0.5 ml of human erythrocytes (type O). When culture... | 0 |
29 | 21,126,610 | Risk reduction for cardiac events after primary coronary intervention compared with thrombolysis for acute ST-elevation myocardial infarction (five-year results of the Swedish early decision reperfusion strategy [SWEDES] trial). | Primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction compares favorably to thrombolysis. In previous studies the benefit has been restricted to the early postinfarction period with no additional risk decrease beyond this period. Long-term outcome after use of third-generation thrombo... | 0 |
30 | 19,585,292 | An evaluation of monitoring practices in patients on second generation antipsychotics. | OBJECTIVE: Treatment with second generation antipsychotics (SGAs) can increase the risk of patients with schizophrenia developing obesity, hyperlipidaemia and diabetes. Routine monitoring is recommended, but clinical practice suggests monitoring is not conducted at a rate necessary for these comorbidities. The aim was... | 0 |
31 | 9,805,216 | Effect of oral contraceptive progestins on serum copper concentration. | OBJECTIVES: Recent epidemiologic studies have shown an increased mortality from cardiovascular diseases in people with higher serum copper levels. Even though higher serum copper concentration in women using oral contraceptives is well known, there is still uncertainty about the influence of newer progestin compounds ... | 0 |
32 | 17,718,871 | Factors associated with low incidence of exclusive breastfeeding for the first 6 months. | BACKGROUND: The identification of factors that are associated with early cessation of exclusive breastfeeding is important for defining strategies for the promotion of exclusive breastfeeding. The objective of this study was to identify the determinants of exclusive breastfeeding cessation before 6 months, including v... | 0 |
33 | 18,638,492 | Models for integrated pest control and their biological implications. | Successful integrated pest management (IPM) control programmes depend on many factors which include host-parasitoid ratios, starting densities, timings of parasitoid releases, dosages and timings of insecticide applications and levels of host-feeding and parasitism. Mathematical models can help us to clarify and predic... | 0 |
34 | 18,451,013 | NAMI perspective on CATIE: policy and research implications. | The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) was designed to assess effectiveness of antipsychotic medication for people with schizophrenia. The authors, who are administrators of the National Alliance on Mental Illness (NAMI), discuss CATIE and related policy and research studies and their i... | 0 |
35 | 12,172,548 | Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. | Familial exudative vitreoretinopathy (FEVR) is a hereditary ocular disorder characterized by a failure of peripheral retinal vascularization. Loci associated with FEVR map to 11q13-q23 (EVR1; OMIM 133780, ref. 1), Xp11.4 (EVR2; OMIM 305390, ref. 2) and 11p13-12 (EVR3; OMIM 605750, ref. 3). Here we have confirmed linkag... | 0 |
36 | 18,095,228 | Optimizing therapy for infections caused by enterobacteriaceae producing extended-spectrum beta-lactamases. | The spread of multidrug-resistant Enterobacteriaceae is complicating the treatment of nosocomial infections. In many parts of the world, resistance to third-generation cephalosporins exceeds 10% of total nosocomial isolates and 30% of isolates detected in the intensive care unit. This resistance is frequently due to th... | 0 |
37 | 19,355,992 | Targeting histone deacetylase inhibitors for anti-malarial therapy. | It is now clear that histone acetylation plays key roles in regulating gene transcription in both eukaryotes and prokaryotes, the acetylated form inducing gene expression while deacetylation silences genes. Recent studies have identified roles for histone acetyltransferases (HATs) and/or histone deacetylases (HDACs) in... | 0 |
38 | 15,953,514 | Effect of aspirin on phase gradient of 2F1-F2 distortion product otoacoustic emissions. | It is well known that aspirin consumption temporarily reduces overall otoacoustic emission (OAE) amplitude in humans. However, little is known about changes in the separate components of distortion product otoacoustic emissions (DPOAE), which may be distinguished by examining phase gradients. The effects of aspirin on ... | 0 |
39 | 21,980,961 | Nebivolol for the treatment of heart failure. | INTRODUCTION: Heart failure (HF) is a common and disabling disease with a high prevalence in the elderly. Beta-blockers are among the mainstay therapies of HF because they antagonize the deleterious effects of the chronic activation of sympathetic nervous system. In large randomized clinical trials, bisoprolol, carved... | 0 |
40 | 19,034,799 | Analysis and integration of developmental neurotoxicity and ancillary data into risk assessment: a case study of dimethoate. | Dimethoate is an organophosphate (OP) pesticide used to control a wide variety of insects on agricultural crops and ornamentals. To ensure that dimethoate is used safely, it is important to determine exposure levels that protect against adverse effects at all life stages, including the developing fetus, infant, and chi... | 0 |
41 | 16,166,793 | Viral etiology of hepatocellular carcinoma and HCV genotypes in Taiwan. | Etiologic variations of hepatocellular carcinoma (HCC) exist in different geographic areas of the world. Hepatitis B virus infection is associated with HCC. However, hepatitis C virus (HCV) infection plays an increasingly more important role in the development of HCC and is associated with more than 30% of HCC in Taiwa... | 0 |
42 | 1,554,830 | Epidemiology of penicillin-resistant Neisseria gonorrhoeae isolated in Taiwan, 1960-1990. | The epidemiology of penicillin-susceptible Neisseria gonorrhoeae isolated in Taiwan from 1960 to 1990 is summarized. The isolation of N. gonorrhoeae less sensitive to penicillin (i.e., with intrinsic resistance) was first reported in 1960. The rate at which organisms less sensitive to penicillin (MIC, greater than or e... | 0 |
43 | 10,680,451 | [Evaluation of selected HLA DRB1 gene alleles as genetic markers of type I diabetes in the population of northeastern Poland]. | Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease and both environmental and genetic factors play a role in its pathogenesis. The second-generation screen of human genome has confirmed that diabetes mellitus type 1 is a polygenic disease. The identification of the alleles with the highest association ... | 0 |
44 | 17,705,861 | Consultation meeting on the development of therapeutic vaccines for post kala azar dermal leishmaniasis. | BACKGROUND: Post kala azar dermal leishmaniasis (PKDL) is a disease that appears after treatment of visceral leishmaniasis (VL). The highest incidence of PKDL in the world is in Sudan. Many patients heal spontaneously within 6 months but those who don't are difficult to treat, often requiring months of daily injection... | 0 |
45 | 9,914,457 | An overview of the fifth-generation implantable cardioverter defibrillator. | It has been established that treatment with an implantable cardioverter is effective for life-threatening arrhythmia including ventricular tachycardia (VT) and ventricular fibrillation (VF). Although most third and fourth-generation implantable cardioverter defibrillator (ICD) models are effective for the treatment of ... | 0 |
46 | 15,036,760 | The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat. | Ammonium perfluorooctanoate (APFO) is a surfactant used primarily as an aid in processing various fluoropolymers. Many toxicology and epidemiological studies have been conducted with APFO; however, no specific information regarding functional reproduction was previously available. Therefore, the potential reproductive ... | 0 |
47 | 12,941,219 | Performance of advanced air bags based on data William Lehman Injury Research Center and new NASS PSUs. | The Ryder Trauma Center is a Level I trauma center that treats only the most severely injured occupants of vehicle crashes as well as other severe cases of trauma. The center investigates these crashes through funding provided by the Alliance of Automobile Manufacturers and the U.S. Department of Transportation-sponsor... | 0 |
48 | 3,357,699 | [Effect of the hybridization of Schistosoma mansoni strains on the degree of compatibility of the parthenitae with their mollusk intermediate hosts]. | After-effects of hybridization of S. mansoni strains, having Biomphalaria pfeifferi as an intermediate host, have been revealed for the first time. The crossing of two african strains (malarial-M and guinea-G), which have different compatibility rates with their specific intermediate hosts, has shown that hybrids displ... | 0 |
49 | 20,691,930 | Dual-energy lung perfusion computed tomography: a novel pulmonary functional imaging method. | Dual-energy computed tomography (DECT) can be used for visualization of pulmonary microvascular contrast material distribution, representing regional perfusion. It is performed as DECT angiography and allows for the reconstruction of morphologic images as well as of "perfusion maps." The authors of previous studies hav... | 0 |
50 | 7,682,256 | Correlation of plasma hepatitis C virus RNA levels with serum alanine aminotransferase in non-A, non-B chronic liver disease. | The relationship between plasma hepatitis C virus (HCV) RNA levels, antibody positivity, and hepatocellular damage were studied in 41 patients with non-A, non-B chronic liver disease. The patients were placed into two groups according to the plasma levels of HCV-RNA: plasma HCV-RNA level was estimated as high when dete... | 0 |
51 | 22,814,775 | Everolimus-eluting stent implantation for unprotected left main coronary artery stenosis. The PRECOMBAT-2 (Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease) study. | OBJECTIVES: This study sought to evaluate the safety and efficacy of second-generation drug-eluting stents (DES) for patients with unprotected left main coronary artery (ULMCA) stenosis. BACKGROUND: The clinical benefit of second-generation DES for ULMCA stenosis has not been determined. METHODS: The authors assessed ... | 0 |
52 | 20,400,208 | [Interpretive reading of the antibiogram in gram positive cocci]. | Resistance to methicillin in Staphylococcus is related to the expression of the mecA gene, and involves resistance to all beta-lactams, with the exception of the new cephalosporins, ceftobiprole and ceftaroline. Breakpoints for interpretation of this mechanism differ in S. aureus and in coagulase-negative species. For ... | 0 |
53 | 10,341,452 | Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations. | One transgenic rabbit line was generated carrying a fusion gene consisting of the cDNA for human IGF-1 fused to a mammary gland specific expression cassette derived from bovine alpha-S1-casein sequences. Transgene expression was shown to be strictly tissue and lactation period specific. The transgenic rabbit line was b... | 0 |
54 | 23,249,760 | Omega-6 polyunsaturated fatty acids and the early origins of obesity. | PURPOSE OF REVIEW: The incidence of obesity and its related metabolic disorders has increased significantly over the past 3 decades, culminating in the current global epidemic of metabolic disease and leading to the search for contributing factors. Exposure of the developing foetus/neonate to a typical Western diet in... | 1 |
55 | 20,166,359 | Ten-year survival of the cemented MS-30 femoral stem: increased revision rate in male patients. | This retrospective study evaluated the clinical and radiographic results of 337 consecutive matte surfaced, straight cemented MS-30 femoral stems implanted with first -to second-generation cementing technique. The median age of the patients at time of surgery was 72 (27-91) years. The median duration of follow-up was 1... | 0 |
56 | 12,704,263 | [Antibiotic prophylaxis in surgery: news and controversies]. | Preoperative administration of antibiotics to prevent possible post-surgical infections represents a cornerstone of modern medicine. Although the general principles of surgical prophylaxis have been quite clearly defined during the last few decades, advenaces in surgical techniques, the changes in bacterial ecology in ... | 0 |
57 | 19,209,622 | Novel homozygous AIRE mutation in a German patient with severe APECED. | Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive disorder typically presenting with chronic mucocutaneous candidiasis, hypoparathyroidism, and adrenal failure variably accompanied by other symptoms. APECED is caused by a mutation in the autoimmune regulator gene (AIR... | 0 |
58 | 22,704,189 | A practitioner's perspective on the application and research needs of membrane bioreactors for municipal wastewater treatment. | The application of membrane bioreactors (MBRs) for municipal wastewater treatment has increased dramatically over the last decade. From a practitioner's perspective, design practice has evolved over five "generations" in the areas of biological process optimization, separating process design from equipment supply, and ... | 0 |
59 | 10,808,218 | Subjective image quality of solid-state and photostimulable phosphor systems for digital intra-oral radiography. | OBJECTIVES: To compare subjectively the image quality of intra-oral radiographs from six digital systems. METHODS: Two generations of two different solid-state detectors; Visualix-1 and -2 (Gendex Dental Systems, Milan, Italy), Computed Dental Radiography (CDR) and CDR Active Pixel Sensor (APS) (Schick Technologies In... | 0 |
60 | 21,442,857 | [Severe psychoses in the elderly--schizophrenia and delusional disorder]. | The number of persons over 65 years of age with schizophrenia will increase in the future. Geriatric schizophrenia involves bizarre delusions and hallucinations similar to those occurring in younger schizophrenic patients. Delusions of an elderly delusional disorder patient focusing on the family and environment easily... | 0 |
61 | 18,564,176 | Glimepiride upregulates eNOS activity and inhibits cytokine-induced NF-kappaB activation through a phosphoinoside 3-kinase-Akt-dependent pathway. | AIMS: Several studies suggest increased mortality postcoronary angioplasty in patients on sulphonylureas. However, a theoretical reduction in cardiac risk has been suggested with the newer sulphonylurea agents, which differ from the first-generation agents. In the present study, we investigated whether a third generat... | 0 |
62 | 6,162,109 | Simultaneous yet independent inheritance of somatically acquired tolerance to two distinct H-2 antigenic haplotype determinants in mice. | We have previously presented evidence that somatically acquired immunological tolerance to foreign histocompatibility antigens induced in male inbred mice can be transmitted at a high frequency to first- and second-generation offspring without exposure of the progeny to the tolerizing antigenic stimulus. These data hav... | 0 |
63 | 8,301,480 | Branchio-oto-renal syndrome: incidence in three generations of a family. | It is well known that the persistence of alterations in the normal embryological development of branchial arches can lead to preauricular and cervical fistulas within a family. However, until 1970, there were no reports of dysplasia affecting the branchial, otic, and renal systems (BOR syndrome) with dominant autosomic... | 0 |
64 | 17,855,268 | [Genetic model analysis of leaf-weight traits in non-heading Chinese cabbage (Brassica campestris ssp. chinensis Makino)]. | The mixed major-gene plus polygene inheritance model was used to analyze the genetics of leafblade-weight and petiole-weight trait in SIxQiu017 of non-heading Chinese cabbage. The results showed that the leafblade-weight trait was controlled by one pair of negative complete dominant major genes plus additive-dominant p... | 0 |
65 | 3,587,137 | Cardiac computed tomography using redundant-ray prospective gating. | A fourth-generation, computed tomographic (CT) scanner, equipped for prospectively gated cardiac imaging, was modified to control the scan data acquisition by using knowledge of the location of redundant rays in the sinogram. In conventional prospective gating, a computer monitors the electrocardiogram (ECG) and calcul... | 0 |
66 | 10,206,239 | Genetic linkage study of panic: clinical methodology and description of pedigrees. | This paper describes the clinical methodology and currently collected pedigrees from an ongoing genetic study of panic disorder. The main objectives are to (1) document the clinical aspects of the study for current [Knowles et al., 1998: Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:138-147] and future reports of gene... | 0 |
67 | 6,549,385 | Lipogenic enzyme activity and fructose 2,6-bisphosphate concentration in livers of two lines of domestic fowl (Gallus domesticus) selected for different body fat content. | Livers were obtained from two lines of domestic broiler which had been selected for low (lean) and high (fat) plasma very-low-density lipoprotein concentration over three generations. The fat line possessed significantly higher hepatic specific activities of malate dehydrogenase (NADP), ATP citrate lyase and fatty acid... | 0 |
68 | 3,716,369 | [Familial idiopathic congestive cardiomyopathy in 2 brothers with a similar course]. | The course of idiopathic congestive cardiomyopathy in two full brothers is described. The diagnosis was made on the base of the existing cardiomegaly, gallop rhythm and congestive cardiac insufficiency, in the absence of any connection with some of the well known causes for hypertrophy and dilation of the heart. It was... | 0 |
69 | 9,316,884 | Generation of the isoprostane 8-epi-prostaglandin F2alpha in vitro and in vivo via the cyclooxygenases. | F2-isoprostanes are isomers of the prostaglandin PGF2alpha. At least one compound of this group, 8-epi-PGF2alpha, exhibits biological activity, and therefore special interest is focused on the mechanism of isoprostane formation: enzyme catalyzed or radical mediated. We analyzed the formation of isoprostanes in vitro an... | 0 |
70 | 18,322,917 | Grandmothers' longevity negatively affects daughters' fertility. | The evolution of postmenopausal longevity in human females has been the subject of debate. Specifically, there is disagreement about whether the evolution of the trait should be understood as an adaptive or a neutral process, and if the former, what the selective mechanism is. There are two main adaptive proposals to e... | 0 |
71 | 17,164,437 | Resistance to high-fat diet in the female progeny of obese mice fed a control diet during the periconceptual, gestation, and lactation periods. | With the worldwide epidemic of metabolic syndrome (MetS), the proportion of women that are overweight/obese and overfed during pregnancy has increased. The resulting abnormal uterine environment may have deleterious effects on fetal metabolic programming and lead to MetS in adulthood. A balanced/restricted diet and/or ... | 0 |
72 | 18,067,012 | Characteristics of and risk factors for pneumonia in patients with hematological malignancies developing fever after autologous blood stem cell transplantation. | We analyzed the incidence, etiology, risk factors and outcomes of 49 episodes of pneumonia that developed in 326 adult patients undergoing autologous stem-cell transplantation (ASCT) from January 1990 to December 2005. The median time for the onset of pneumonia after transplantation was 11 days (range 0-148). Empirical... | 0 |
73 | 8,945,645 | Custodial grandparenting: new roles for middle-aged and older adults. | An overview of grandparenting in light of changing demographics, family composition, and intergenerational dynamics is presented, as well as a review of custodial grandparenting which is impacted not only by these changes, but also by factors unique to this role. Research to date suggests that the demands of custodial ... | 0 |
74 | 7,698,698 | Variables associated with the risk of colorectal adenomas in asymptomatic patients with a family history of colorectal cancer. | The results of screening individuals referred to the Family Cancer Clinic at St Mark's Hospital from 1986 are presented. Colonoscopy was performed in 644 asymptomatic individuals (from 436 families) with a family history of colorectal cancer. Sixty nine (15.8%) of the families fulfilled the Amsterdam criteria for the h... | 0 |
75 | 20,218,696 | Total synthesis of (+/-)- and (-)-actinophyllic acid. | Development of efficient sequences for the total syntheses of (+/-)-actinophyllic acid (rac-1) and (-)-actinophyllic acid (1) are described. The central step in these syntheses is the aza-Cope/Mannich reaction, which constructs the previously unknown hexacyclic ring system of actinophyllic acid in one step from much si... | 0 |
76 | 17,983,255 | Estrogen receptor modulators and down regulators: optimal use in postmenopausal women with breast cancer. | Endocrine treatments have been used in breast cancer since 1896, when Beatson reported on the results of oophorectomy for advanced breast cancer. In the second half of the last century, different endocrine-based compounds were developed and, in this review, the role of the selective estrogen receptor modulators (SERMs)... | 0 |
77 | 22,155,899 | Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract. | HIV resides within anatomical 'sanctuary sites', where local drug exposure and viral dynamics may differ significantly from the systemic compartment. Suboptimal antiretroviral concentrations in the genital tract may result in compartmentalized viral replication, selection of resistant mutations and possible re-entry of... | 0 |
78 | 12,937,707 | Intergenerational interaction in health promotion: a qualitative study in Brazil. | OBJECTIVE: In 1994 a pilot intergenerational project was started in the city of Taguatinga, Brazil, to promote the well-being of both elderly and adolescent populations using reminiscence processes as a means of interaction. The purpose of the study is to evaluate the project from the participants' viewpoint and to im... | 0 |
79 | 14,743,775 | Cost-effective pharmacotherapy for inhalant allergic rhinitis. | The otolaryngologist is one of the decision leaders for patients who seek to learn more about their problems of respiratory allergy. Although these patients do not have a life-threatening illness, the reduction of quality of life and performance can significantly restrict their overall sense of well being. Patients wit... | 0 |
80 | 7,922,928 | Antimicrobial prophylaxis in surgery. Committee on Antimicrobial Agents, Canadian Infectious Disease Society. | OBJECTIVE: To provide guidelines for antimicrobial prophylaxis on the basis of the type of surgical procedure. OPTIONS: Standard drug regimens for prophylaxis of infection in a variety of surgical procedures were considered, including a first-generation cephalosporin; an aminoglycoside in combination with metronidazol... | 0 |
81 | 2,461,658 | Inherited retinal venous beading. | Four affected family members in two generations demonstrated an unusual, probably autosomal dominant, retinal vascular disorder called inherited retinal venous beading. The proband had retinal neovascularization, exudation, and vitreous hemorrhage. The other three affected family members had significant venous beading ... | 0 |
82 | 8,671,130 | What do patients expect from consultations for upper respiratory tract infections? | BACKGROUND AND OBJECTIVE: A cross-sectional survey was conducted amongst patients who consulted for upper respiratory tract infections (URTI) at 22 private practitioners' offices. METHOD: A total of 505 adult patients and 504 guardians (parents or grandparents of child patients) completed a self-administered questionn... | 0 |
83 | 19,157,666 | Transitions in living arrangements of Canadian seniors: findings from the NPHS longitudinal data. | This paper examines transitions in living arrangement decisions of the seniors using the first six cycles of the Canadian longitudinal National Population Health Survey microdata. Transitions from independent to intergenerational and institutional living arrangements are uniquely analyzed using a discrete-time hazard r... | 0 |
84 | 16,738,076 | Genetic and environmental influences on type A behavior pattern: evidence from twins and their parents in the Netherlands Twin Register. | OBJECTIVE: There is a dose-response positive relationship between type A behavior (TABP) and cardiovascular disease-related symptoms. Estimates of heritability for TABP from previous studies vary; this might be explained by limitations in the sizes and compositions of the samples. METHODS: This study combines a large ... | 0 |
85 | 19,442,855 | Assessment of sensitivity and specificity of first, second, and third generation EIA for the detection of antibodies to HIV-1 in oral fluid. | The performances of three blood-based immunoassays test kits were compared with regard to their ability to detect HIV-1 antibody in oral fluid. It was found that these three kits differ in their ability to detect HIV-1 antibody. Notably, a third generation EIA which has been shown to possess superior sensitivity for an... | 0 |
86 | 15,504,599 | Minocycline attenuates gentamicin induced hair cell loss in neonatal cochlear cultures. | Minocycline, a second-generation tetracycline antibiotic used against gram-negative and gram-positive bacteria, protects against a wide range of neurodegenerative disorders by inhibiting caspases, iNOS and the release of cytochrome c. Since aminoglycoside antibiotics damage sensory hair cells in the inner ear by activa... | 0 |
87 | 8,755,026 | [The occurrence of micronuclei in generations of HeLa cells irradiated at low doses]. | The frequency of cells with pronuclei was determined among the cells subject to acute and long-term treatment and their descendants. It remained unchanged after acute irradiation (60Co) at doses of 10-40 cGy but was elevated in three generations after long-term irradiation (137Cs, 20-40 cGy) and residence in the Cherno... | 0 |
88 | 8,990,404 | Molecular biology of plasminogen activators: what are the clinical implications of drug design? | The initial work on thrombolytic therapy for acute myocardial infarction (AMI) focused on intracoronary administration of streptokinase. Continuing research has given rise to the development of both second- and third-generation agents and consequent refinements in thrombolytic regimens. Intravenous recombinant tissue p... | 0 |
89 | 17,699,534 | Ethnicity as a correlate of the uptake of the first dose of mumps, measles and rubella vaccine. | The aim of this study was to investigate whether a relationship exists between ethnicity and uptake of the first dose of mumps, measles and rubella (MMR1) vaccination, and to study important factors influencing the parental decision about vaccination. Examination of routine data on uptake of MMR1 vaccine among children... | 0 |
90 | 14,989,286 | Dame Sheila Patricia Violet Sherlock. | Dame Sheila Patricia Violet Beckett Sherlock was the world's leading female physician-scientist of the twentieth century. Her brilliant, wide-ranging, original contributions to the investigation, diagnosis, classification, epidemiology, pathogenesis and management of liver disease played a leading role in the establish... | 0 |
91 | 6,831,857 | Silent reading: insights from second-generation deaf readers. | null | 0 |
92 | 7,613,038 | A genetic map of microsatellite markers on rat chromosome 7. | Nine microsatellite loci were mapped to rat Chromosome (Chr) 7 by genetic linkage and somatic cell hybrid analysis. These loci include the gene encoding a member of the IID sub-family of cytochrome P450 (Cyp2d), a gene with repetitive sequences expressed during myotube formation (D7Arb1e), four anonymous loci, D7Arb81,... | 0 |
93 | 17,224,956 | Gamma interferon assay as an alternative to PPD skin testing in selected patients with granulomatous intraocular inflammatory disease. | BACKGROUND: To evaluate the QuantiFERON-TB test (gamma interferon assay), approved by the Centers for Disease Control and Prevention for the detection of latent tuberculosis (LTB), in patients who potentially may require immunosuppressive therapy for ocular inflammatory disease. METHODS: Blood samples from 12 consecut... | 0 |
94 | 434,891 | Familial occurrence of omphalocele suggesting sex-linked inheritance. | A family is described in which 4 males in two generations had omphalocele. There was no case of omphalocele in any of the women. It is suggested that the mode of inheritance could be a sex-linked recessive trait. | 0 |
95 | 11,059,221 | In vitro susceptibilities to 23 antimicrobial agents of Haemophilus influenzae from pediatric patients in Japan. | One hundred eighty-six clinical isolates of Haemophilus influenzae (H. influenzae) collected from January 1996 through December 1997 from 182 pediatric patients and 16 isolates from blood or cerebrospinal fluid (CSF) of 13 patients with bacteremia and purulent meningitis collected during the last ten years were examine... | 0 |
96 | 7,468,656 | Familial occurrence of bifid femur and monodactylous ectrodactyly. | Two brothers each had one normal upper limb; one had tridactylous ectrodactyly of one hand with normal forearm bones; the other had monodactyly of one hand with absent ipsilateral ulna. Both had monodactyly of the feet, absence of the tibiae, and unilateral bifurcation of the femur. A sister of the paternal grandfather... | 0 |
97 | 17,435,317 | Antisense expression of a gene encoding a calcium-binding protein in transgenic tobacco leads to altered morphology and enhanced chlorophyll. | Entamoeba histolytica contains a novel calcium-binding protein like calmodulin,which was discovered earlier,and we have reported the presence of its homologue(s)and a dependent protein kinase in plants.To understand the functions of these in plants,a cDNA encoding a calcium-binding protein isolated from Entamoeba histo... | 0 |
98 | 19,618,482 | Development of a scalable process for high-yield lentiviral vector production by transient transfection of HEK293 suspension cultures. | BACKGROUND: Lentiviral vectors (LV) offer several advantages over other gene delivery vectors. Their potential for the integration and long-term expression of therapeutic genes renders them an interesting tool for gene and cell therapy interventions. However, large-scale LV production remains an important challenge fo... | 0 |
99 | 1,850,194 | SV40-transformed fragile (X) amniocytes. | We report SV-40 transformation of female and male fragile X [fra(X)] amniocytes. In the transformants, fra(X) (q27.3) was detected in the 7th passage (9 cell generations) in fra(X) female amniocytes. It was conserved until at least the 20th passage (42 cell generations) although the frequency was reduced or became diff... | 0 |
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howard-transgenerational-clean
This dataset was created from the file transgenerational-clean.csv in the collection of data files.
Dataset Structure
The dataset contains 48633 rows and 5 columns.
Features
recordId: int64PMID: int64title: objectabstract: objectlabels: int64
Source
Original file: transgenerational-clean.csv
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