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11373_2007_9226_Fig1_HTML.jpg
Colocalization of hNopp140, pol I and rDNA repeats. ( a ) Distribution of hNopp140 and pol I. The rounded-up mitotic cells were collected from HeLa culture by mechanical shake-off (upper panel; arrows for anaphase, arrowheads for telophase). The attached cells were at interphase (lower panel). Cells were subjected to d...
true
ImageCLEF
12178_2007_9002_Fig3_HTML.jpg
( a ) Transverse view of the proximal long head of the biceps in the bicipital groove. ( b ) Same image as in ( a ). Now the transducer is not 90 degrees to the tendon, causing it to appear hypoechoic (darker). This may mimic a tear of the tendon and is referred to as anisotropy
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ImageCLEF
12178_2007_9003_Fig1_HTML.jpg
An 64-year-old female with symptoms of bilateral lower limb neurogenic claudication with symptomatic improvement with a caudal epidural steroid injection. An interlaminar approach could have been considered appropriate, as well. ( a ) Sagittal view of a T2-weighted MRI of the lumbar spine. Note the grade I spondylolist...
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ImageCLEF
12178_2007_9003_Fig3_HTML.jpg
Fluoroscopic images of an L3-4 interlaminar approach. ( a ) AP view, pre-contrast, ( b ) Lateral view, pre-contrast, and ( c ) Lateral view, post-contrast
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ImageCLEF
12178_2007_9003_Fig5_HTML.jpg
Fluoroscopic images of a right L5-S1 transforaminal approach targeting the right L5 nerve root. ( a ) AP view, pre-contrast and ( b ) AP view, post-contrast
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12178_2007_9006_Fig5_HTML.jpg
Proximal and distal translation of superior and inferior poles of patella within trochlear groove. ( a ) Proximal translation ( b ) Distal translation
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12178_2007_9006_Fig6_HTML.jpg
Assessment for patellofemoral joint crepitation during active range of motion. ( a ) Extension ( b ) Flexion
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12178_2007_9007_Fig1_HTML.jpg
Steps of kyphoplasty
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12178_2007_9013_Fig1_HTML.jpg
Preoperative ( a ) and postoperative ( b ) roentgenograms of a 63-year-old patient who underwent kyphoplasty of a T12 compression fracture. The anterior vertebral height increased 4   mm and the kyphotic deformity decreased 5.6 °
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ImageCLEF
12178_2008_9027_Fig4_HTML.jpg
( a ) This anteroposterior radiograph demonstrates a minimally displaced type II supracondylar fracture. ( b ) The lateral view shows slight posterior angulation of the distal fracture fragment. ( c ) After 4   weeks in a cast, there has been interval healing and elbow range of motion may be started
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ImageCLEF
12178_2008_9039_Fig2_HTML.jpg
Oblique view of the lumbar spine. SAP superior articular process, IAP inferior articular process, P pedicle
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12178_2009_9055_Fig3_HTML.jpg
Eccentric calf stretches and strengthening exercises. Courtesy : R. Michael Galbraith
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ImageCLEF
12178_2009_9056_Fig10_HTML.jpg
CTS patient #5. Longitudinal view of the median nerve pre-stress ( a ) and during stress ( b ). The median nerve is the darker, hypoechoic linear (or tubular) structure bordered by a thin hyperechoic rim (epineurium) traversing from the left to the right side of the image. The brighter, hyperechoic tubular structure wi...
true
ImageCLEF
12178_2009_9056_Fig11_HTML.jpg
CTS patient #6. Longitudinal view of the median nerves pre-stress ( a , b ) and during stress ( c , d ). The median nerve is the darker, hypoechoic linear (or tubular) structure bordered by a thin hyperechoic rim (epineurium) traversing from the left to the right side of the image. The brighter, hyperechoic tubular s...
true
ImageCLEF
12178_2009_9056_Fig12_HTML.jpg
CTS patient #7. Longitudinal view of the median nerve pre-stress ( a ) and during stress ( b ). The median nerve is the darker, hypoechoic linear (or tubular) structure bordered by a thin hyperechoic rim (epineurium) traversing from the left to the right side of the image. The brighter, hyperechoic tubular structure wi...
true
ImageCLEF
12178_2009_9056_Fig3_HTML.jpg
Normal Subject #3. Longitudinal view of the median nerve pre-stress ( a ) and during stress ( b ). The median nerve is the darker, hypoechoic linear (or tubular) structure bordered by a thin hyperechoic rim (epineurium) traversing from the left to the right side of the image. The brighter, hyperechoic tubular structure...
true
ImageCLEF
12178_2009_9056_Fig5_HTML.jpg
Normal subject #5. Longitudinal view of the median nerve pre-stress ( a ) and during stress ( b ). The median nerve is the darker, hypoechoic linear (or tubular) structure bordered by a thin hyperechoic rim (epineurium) traversing from the left to the right side of the image. The brighter, hyperechoic tubular structure...
true
ImageCLEF
12178_2009_9056_Fig9_HTML.jpg
CTS patient #4. Longitudinal view of the median nerve pre-stress ( a ) and during stress ( b ). The median nerve is the darker, hypoechoic linear (or tubular) structure bordered by a thin hyperechoic rim (epineurium) traversing from the left to the right side of the image. The brighter, hyperechoic tubular structure wi...
true
ImageCLEF
1297-9686-41-26-1.jpg
Estimated (----) additive genetic variance and variance explained by a QTL compared to the simulated (----) parameters for a short depth of pedigree (see text for details) . Figure 1a presents results for MA-BLUP models using only daughter yield deviations (DYD) of bulls as phenotypic information, whereas Figure 1b sho...
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ImageCLEF
1297-9686-41-26-2.jpg
Estimated (----) additive genetic variance and variance explained by one QTL in comparison to their simulated (----) parameters when phenotypic information is used for bulls and cows . Phenotypic information corresponds to daughter yield deviations (DYD) of bulls and yield deviations (YD) of cows; Figure 2a presents re...
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ImageCLEF
1297-9686-41-46-2.jpg
Across-family statistical profiles obtained on chromosomes 1, 10 and 14 for the four parasite resistance traits analysed in the present study . The x -axis indicates the relative position on the linkage map (cM Haldane); the y-axis represents the log (1/p g -value); information content (IC) obtained along the linkage ...
true
ImageCLEF
1297-9686-42-35-3.jpg
Variables affecting long-term response to genomic selection . Simulations at heritability of 0.5 using ridge regression to estimate breeding values and model updating every other season. Squares and continuous lines: phenotypic selection; circles vs triangles: small vs. large training population; closed vs open: unweig...
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ImageCLEF
1297-9686-42-5-3.jpg
Accuracy of EBVs, ρ , obtained by BayesB, G-BLUP and P-BLUP depending on the maximum additive-genetic relationship between bulls in training and dev, a max , for the traits milk yield, fat yield, protein yield and somatic cell score, based on 2,096 training bulls in each a max scenario .
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1297-9686-42-5-4.jpg
Accuracy of EBVs, ρ , obtained by BayesB, G-BLUP and P-BLUP depending on the maximum additive-genetic relationship between bulls in training and dev, a max , for the traits milk yield, fat yield, protein yield and somatic cell score, based on 1,048 training bulls in each a max scenario .
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ImageCLEF
1297-9686-43-21-3.jpg
Means ± one standard deviations of genetic correlations within classes of number of common bulls between countries . The common bulls were defined as bulls having daughters in both countries of inspection without restriction on the country of origin of the bulls.
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1297-9686-43-22-1.jpg
QTL map of the entire genome for extended lactation of milk and milk composition .
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1297-9686-43-22-2.jpg
QTL map of the entire genome for milk and milk composition persistency .
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1297-9686-43-24-5.jpg
Overview canonical pathways . Ingenuity canonical pathways affected during time-course between inoculated and control cells in SCS-BTA18-Q and SCS-BTA18-q cells inoculated with E. coli and S. aureus , respectively; blue bars indicate p-value significance and the orange threshold line indicates the p ≤ 0.05 signifi...
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ImageCLEF
1297-9686-43-28-1.jpg
Comparing the metabolic traits between breeds . a) Bar plots of metabolic traits that significantly differed across sexes and breeds i.e. Duroc (DU), Iberian (IB), Landrace (LR), Large White (LW) and a Sino-European hybrid line (YL). b) Dendrogram of the four pig breeds (DU, IB, LR, LW) in terms of average standardized...
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ImageCLEF
1297-9686-43-28-3.jpg
Analysis of multiple tissue network for non-esterified fatty acids . a) Distribution of probeset connectivity in the multiple-tissue network. b) Box plot of standardized inter-tissue connectivity of genes in the five tissues i.e. backfat (FATB), gonad (GONA), adenohypophysis (AHYP), thyroid (THYG) and hypothalamus (HYP...
true
ImageCLEF
1423-0127-16-109-3.jpg
A. Three dimensional model of class C protein (PDB code 2QZ6 ) showing group C specific motif identified from present study in red colour and class C specific PROSITE motif in orange . The active site region is highlighted with dotted surface while the known two of the three conserved regions playing a role in activ...
true
ImageCLEF
1423-0127-16-113-2.jpg
Epitope mapping of monoclonal antibody R2-25 . ( A ) Schematic diagram of truncation constructs of Hsc70. A linear diagram of full-length Hsc70 is shown at the top; numbers indicate the corresponding amino acid position. The ATPase domain (ATPase), peptide binding domain (PBD), and C-terminal region (C) are shown. The ...
true
ImageCLEF
1423-0127-16-113-4.jpg
Binding of TPR proteins to Hsc70 . ( A ) TPR proteins binding capacity for Hsc70 with or without EEVD or scrambled EEVD (sEEVD: CAPISEDGSGETV) peptides as measured by ELISA. Immunoplates were coated with TPR-Ba, TPR-Lm1, TPR-Lm2 proteins or BSA (Cont.) and then Hsc70 was added. Data are the averages of triplicate sampl...
true
ImageCLEF
1423-0127-16-17-6.jpg
Silencing of Clathrin heavy chain in HepG2 cells . Multiplex RT-PCR products for GAPDH or clathrin heavy chain (CHC) of HepG2 cells either mock transfected (A); transfected with siGFP (B); transfected with siCHC3 (C) or transfected with siCHC5 (D). Samples represent day 1 to 4 post transfection and transfections were u...
true
ImageCLEF
1423-0127-16-17-8.jpg
Infection of siRNA silenced HepG2 cells . A. HepG2 cells either mock transfected (mock) or transfected with siGFP, siCHC3 or siCHC5 were infected with dengue virus serotype 2 at MOI 20 and the number of infected cells determined by our adaptation of the standard plaque assay [ 15 ]. Results are expressed as a percentag...
true
ImageCLEF
1423-0127-16-23-1.jpg
Surface 12-lead ECG of the three patients with Brugada syndrome carrying SCN5A mutation .
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ImageCLEF
1423-0127-16-3-1.jpg
Direct DNA sequencing of exon 2 of CYP21A2 gene . (A) Sequence of mutated allele showing heterozygous insertion in exon 2 resulting in additional three valine residues after codon 70. The inserted sequence and the corresponding valine residues are boxed. The site of insertion is indicated by an arrow. (B) The lower seq...
true
ImageCLEF
1423-0127-16-33-7.jpg
VEGF-shRNA downregulates expression of VEGF and Del1 in vitro . LS-174T cells were transfected with VEGF-shRNA and harvested 48 h later. (A) VEGF (upper row) and Del1 proteins (middle row) in lysates of untreated cells (lane 1) or cells transfected with control vector (lane 2), or VEGF-shRNA plasmid (lane 3) was Weste...
true
ImageCLEF
1423-0127-16-35-4.jpg
A: The analysis of nuclear factor NF- κ B and AP-1 from the nuclear extracts of liver samples at 6 hr of D-GalN treatment were performed with a nuclear extraction kit and using a commercially Electrophoretic-Mobility Shift Assay . The induction of nuclear factor NF- κ B and AP-1 nuclear factors by D-GalN treatment is p...
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ImageCLEF
1423-0127-16-35-5.jpg
A: Green tea (GT) extracts inhibit the mitochondrial apoptosis-signaling pathway . The cytosolic and mitochondrial fractions were prepared at 6 hr after D-GalN from the livers and subjected to western blot analysis for Bax and cytochrome c (Cyt c), respectively. Note that GT treatment decreased the D-GalN-induced cytos...
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ImageCLEF
1423-0127-16-35-8.jpg
Determination of multiple cytokines determination by cytokine antibody array in the plasma from control, 24 hr after D-GalN treatment, and 24 hr of after D-GalN and green tea (D-GalN+GT) pretreatment . The plasma cytokine profiles are displayed in A . The mean changes (indicated by ratios of control) of 6 cytokines (n...
true
ImageCLEF
1423-0127-16-41-3.jpg
IL-6 decreases the levels of HBV transcripts, core protein, and genome-containing nucleocapsids . Confluent cells (day0) were treated with or without 20 ng/ml of IL-6 for 2 days (day2), 4 days (day4) or 6 days (day6). For RNA analysis (panel for RNA), total RNAs were extracted and equal amounts of samples were subjecte...
true
ImageCLEF
1423-0127-16-43-1.jpg
ASK1 activation is involved in denbinobin-induced apoptosis in A549 cells . (A) A549 cells were transiently transfected with pcDNA (mock) or ASK1DN for 6 h. Following transfection, cells were replaced with fresh culture medium for 24 h and treated with vehicle or 20 μ M denbinobin for another 24 h. The percentage of a...
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ImageCLEF
1423-0127-16-43-2.jpg
ROS generation mediates denbinobin-induced apoptosis in A549 cells . (A) Following pretreatment with NAC (1 mM) or GSH (100 μ M) for 30 min, cells were incubated with the vehicle or 20 μ M denbinobin for another 24 h. Cells then were harvested, and apoptosis was analyzed by flow cytometry as described in "Materials a...
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ImageCLEF
1423-0127-16-43-3.jpg
Involvement of JNK activation in denbinobin-induced apoptosis in A549 cells . (A) Cells were pretreated with SP600125 (10 μ M) for 30 min before incubation with 20 μ M denbinobin for 24 h, and then apoptosis was detected using flow cytometry of PI-stained cells as described in "Materials and methods". Each column rep...
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ImageCLEF
1423-0127-16-43-4.jpg
Involvement of ROS and ASK1 in denbinobin-induced JNK activation in A549 cells . Cells were pretreated with 1 mM NAC or 100 μ M GSH (A) or transiently transfected with pcDNA or ASK1DN for 6 h (B) before incubation with 20 μ M denbinobin for 30 min. Cells were then harvested and subjected to immunoblotting for JNK pho...
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ImageCLEF
1423-0127-16-43-5.jpg
Involvement of AP-1 activation in denbinobin-induced apoptosis in A549 cells . (A) Cells were pretreated with curcumin (1 μ M) for 30 min before incubation with 20 μ M denbinobin for another 24 h, and then apoptosis was detected using flow cytometry of PI-stained cells as described in "Materials and methods". Each co...
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ImageCLEF
1423-0127-16-43-6.jpg
Involvement of ROS, ASK1, and JNK in denbinobin-induced c-Jun phosphorylation in A549 cells . Cells were pretreated with 1 mM NAC, 100 μ M GSH (A), or 10 μ M SP600125 (B), or transiently transfected with pcDNA, ASK1DN, JNK1DN, or JNK2DN for 6 h (C). After treatment, cells were treated with vehicle or 20 μ M denbinob...
true
ImageCLEF
1423-0127-16-43-7.jpg
Bim expression is involved in denbinobin-induced apoptosis in A549 cells . (A) Following transfection with control siRNA or bim siRNA for 6 h, cells were treated with vehicle or 20 μ M denbinobin for another 24 h. The DNA content was then analyzed by flow cytometry of PI-stained cells as described in "Materials and ...
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ImageCLEF
1423-0127-16-51-1.jpg
Similarity between Mars and HURP is higher than that between Vulcan and HURP . (A) Diagrams show conserved domains in HURP, Mars and Vulcan (Vlc). The sizes of the GKAP domains in HURP, Mars and Vlc are 297 (301 – 597), 315 (452 – 766) and 323 (266 – 588) amino acids, respectively. The amino acid sequences of the HURP ...
true
ImageCLEF
1423-0127-16-57-3.jpg
Tracings showing [Ca 2+ ] i (indicated by fluorescence ratio of fura-2 at 340 nm and 380 nm) transient in rat aortic endothelial cells . ACh (3 μ mol/L) elicited increases in [Ca 2+ ] i in fura-2-loaded endothelial cells. Vehicles of LPC and benidipine had no effect on ACh-induced increases in [Ca 2+ ] i (A). LPC (...
true
ImageCLEF
1423-0127-16-59-3.jpg
3D structure models of proteins . Models for proteins WAH-1 (modeled amino acids 238 – 700 of 700), CPS-6 (modeled amino acids 57 – 305 of 308), and endoG (modeled amino acids 65 – 296 of 297) were calculated using Phyre server. Model of HSP70-1 (modeled amino acids 1 – 554 of 641) was calculated by server M4T. Structu...
true
ImageCLEF
1423-0127-16-6-3.jpg
Kinetic analysis of human EndoG . (A) Electrophoresis analysis. EndoG (0.05 pmol) was mixed with various amounts of supercoiled pUC18 dsDNA and incubated at 37 ° C for 3 min. The resulting products were then analyzed by 1.2% agarose gels. Arrowheads denote the different topological forms of pUC18 plasmids. OC: open cir...
true
ImageCLEF
1423-0127-16-6-4.jpg
Magnesium requirements of human EndoG variants . (A) Electrophoresis analysis. EndoG variants were mixed with 0.1 μ g of linear pUC18 dsDNA in EndoG buffer containing various amounts of magnesium. The reaction mixtures were incubated at 37 ° C for indicated periods. The resulting products were analyzed by 1.2% agarose...
true
ImageCLEF
1423-0127-16-6-5.jpg
Cleavage specificities of human EndoG variants . (A)Sequence-specific cleavage assay. The structure of Eco R I-linearized pKJH20 DNA is shown at the top, with the open box designating the GC-rich sequence region (0.3 kb). Xba I site is located 1.6 kb from the Eco R I site at the 3' end of the linear pKJH20 DNA. In ...
true
ImageCLEF
1423-0127-16-62-1.jpg
Average classification error rate (percent) over 100 runs on different genotypes from 10-fold cross-dev .
true
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1423-0127-16-7-1.jpg
Scanning electron microscope images of the TiO 2 nanoparticles . (A) C150, (B) C200, (C) EDS elemental spectrum of C200, (D) S. aureus and UV100, (E) S. aureus and C150, and (F) S. aureus and C200. Scale bars: 100 nm.
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ImageCLEF
1423-0127-16-70-1.jpg
Perfusion of hearts with DETA/NO partially prevents the ischemia-induced decrease in respiratory chain activity and increase in proton leak of subsequently isolated mitochondria . (A): kinetics of the respiratory chain activity, and (B): kinetics of proton leak. Rat hearts were perfused for 3 min with 50 μ M of DETA/N...
true
ImageCLEF
1423-0127-16-8-5.jpg
Representative Western blots of neuronal nitric oxide synthase (nNOS), inducible NOS (iNOS) or endothelial NOS (eNOS) (insets) or densitometric analysis in amount of protein relative to α -tubulin from the heart at 1 or 4 h after systemic injection of LPS (15 mg/kg) in rats that were maintained under propofol anesthes...
true
ImageCLEF
1423-0127-16-81-6.jpg
Confocal microscopy of embryonic axolotl hearts treated with double-stranded MIR . The images show those hearts that stopped beating after 4 days but regained contractions later. Hearts were fixed after 9 days in culture. Normal heart (stage 36) organ cultured with lipofectin in Steinberg's Solution only for 10 days (A...
true
ImageCLEF
1423-0127-16-87-1.jpg
Effects of HG/SMG on the proliferation of BMSCs . BMSCs were plated onto glass coverslips, transferred to a biocompatible polyethylene culture bag [ 27 ], then cultured under HG or SMG conditions for 1- -7 days. The cells were fixed with 4% paraformaldehyde and proliferation was assessed by the methylene blue method. H...
true
ImageCLEF
1423-0127-16-87-2.jpg
Effects of HG/SMG on the osteogenic differentiation of rBMSCs . rBMSCs were cultured under HG/SMG conditions with or without osteoblastic inducement medium for 1, 3, 5 or 7 days during a culture period of 14 days. RT-PCR analysis for ALP, cbfa1 and ColIA1 mRNA expressions:(A) Electrophoresis graph of PCR products, B) G...
true
ImageCLEF
1423-0127-16-87-3.jpg
Effects of HG/SMG on cardiomyogenic differentiation of rBMSCs . rBMSCs were cultured under HG/SMG conditions with or without cardiomyocyte inducement medium for 1 or 3 days. RT-PCR analysis of β -MHC and GATA-4 mRNA expressions; (A) Electrophoresis graph of PCR products, (B) Gray intensity analysis of electrophoresis ...
true
ImageCLEF
1423-0127-16-87-4.jpg
Effects of HG/SMG on the adipogenic differentiation of rBMSCs . rBMSCs were cultured under HG/SMG conditions with or without adipogenic inducement medium for 1, 3, 5 or 7 days of a total culture period of 14 days. RT-PCR analysis of PPAR γ 2 mRNA expression. (A) Electrophoresis graph of PCR products, (B) Gray intensity...
true
ImageCLEF
1423-0127-16-87-5.jpg
Effects of HG on rBMSCs differentiation into force-sensitive cells . rBMSCs were cultured under HG conditions for 7 or 21 days. Cells were then analyzed by FACS with a cTnT-specific monoclonal antibody to detect cardiomyogenic differentiation, or a Cbfa1-specific antibody to detect osteoblastic differentiation. C, stat...
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ImageCLEF
1423-0127-16-88-1.jpg
Trophoblast differentiation from embryoid bodies on the biomimetic platform . Panel (a) shows a non-cystic early EB. Panel (b) shows a late cytic EB with clear fluid filled cavity (red arrow) and a small mass of cells similar to inner cell mass (ICM) of an embryos (green arrowhead) pushed towards the top. Panel (c) sho...
true
ImageCLEF
1423-0127-16-98-3.jpg
Oligomycin-induced Cellular ROS Production and Cell Death in HT-22 Cells . A : Flow cytometric analysis of cellular ROS levels with the simultaneous use of CM-H 2 DCFDA and MitoSOX red and the effect of oligomycin treatment (10 μ g/ml, 2 hr). DCF: dichlorofluorescein. MFI: median fluorescence intensity. B : Phase co...
true
ImageCLEF
1423-0127-17-16-4.jpg
Effect of NaVP on transcriptional regulation of various cardiac development-related genes . Gene expression levels were analyzed using RT-PCR techniques as described in Materials and Methods. (A) A representative RT-PCR analysis of HDAC1, HDAC2, MEF2C, CHF1, GATA4, Nkx2.5 CHF1, Tbx5 and MEF2C mRNA expression in E16 fet...
true
ImageCLEF
1423-0127-17-34-3.jpg
Three domains of AAG A (or C)-chain: (a) domain γ 1, (b) domain γ 2, (c) domain γ 3 . These figures were generated by O program (Jones et al., 1991).
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ImageCLEF
1423-0127-17-34-5.jpg
Two domains of AAG B (or D)-chain: (a) domain δ 1, and (b) domain δ 2 . These figures were generated by O program (Jones et al., 1991).
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ImageCLEF
1423-0127-17-34-6.jpg
Electron density of the NAG (red) near B 100Asn using the (2Fo - Fc) map contoured at 2.0 F . This figure was generated by O program (Jones et al., 1991).
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ImageCLEF
1423-0127-17-34-7.jpg
Three domains of AAG A (or C)-chain are drawn as ribbons . (a) Gray purple and green indicate domain γ 1 and green indicate domain γ 1 γ 2 γ 2 and γ 3 respectively. Active site residues are drawn in red. (b) Active Site comparison of abrin-a (red) and γ 3 respectively. Active site residues are drawn in red. (b) A...
true
ImageCLEF
1423-0127-17-40-1.jpg
Expression of EGFP, EGFP-NS1 and EGFP-NS1K334E . (A) The COS-7 cells transfected with pEGFP, pEGFP-NS1 or pEGFP-NS1K334E were observed under phase contrast (upper panel) and fluorescence microscope (middle panel). The fluorescence intensity was also detected using flowcytometry (lower panel). The (B) mRNA and (C) prote...
true
ImageCLEF
1423-0127-17-47-2.jpg
Replication of HSV-1 in the SIRC cell line . SIRC cells were infected with the KOS strain of HSV-1 at an MOI of 1 for 48 h (B). Mock-infected SIRC cells cultured in parallel were left untreated (A). HSV-1 replication was examined by confocal microscopy after staining with an HSV gD protein-specific rabbit polyclonal an...
true
ImageCLEF
1423-0127-17-6-1.jpg
Fluorescence images of transfected A7r5 cells . All CaD constructs were EGFP-tagged (left panels); actin was stained with red (middle panels). Merged images are shown on the right panels. Cells were transfected with EGFP (control, Row e), EGFP-wtCaD (wild-type CaD; Row f) and CaD mutant, including EGFP-A1A2 (Row a), EG...
true
ImageCLEF
1423-0127-17-72-5.jpg
Transcriptional activation of HO-1 leads to preferential upregulation of NOS I/PKG signaling in RVLM . Illustrative gels or summary of fold changes against aCSF controls in ratio of nitric oxide synthase I (NOS I), protein kinase G (PKG), NOS II or nitrotyrosine (NT) relative to β -actin protein detected in ventrolate...
true
ImageCLEF
1423-0127-17-72-6.jpg
Knockdown of ho-1 gene antagonized selectively the activation of HO-1 in RVLM . Illustrative gels or summary of fold changes against aCSF controls in ratio of HO-1 ( A ) or HO-2 ( B ) relative to β -actin protein detected in ventrolateral medulla of rats that received knockdown of ho-1 or ho-2 gene in RVLM 24 h ...
true
ImageCLEF
1423-0127-17-74-1.jpg
Analysis and identification of membrane proteins in AsPC-1 and BxPC-3 cells using a proteomics approach based on SDS-PAGE, in-gel digestion and LC-MS/MS . (A) Membrane proteins were isolated, separated with SDS-PAGE and detected with Simply Blue stain. The gel bands were then excised and digested with trypsin, and the ...
true
ImageCLEF
1423-0127-17-79-1.jpg
Nucleotide sequences of the neighboring regions of the mutations in the GLB1 gene of two GM1 gangliosidosis patients . The mutant sequencing diagrams are shown. The position of each mutation is marked with an arrow (panels A-D). Wild-type and mutant nucleotide and amino acid sequences are presented using A of the ATG s...
true
ImageCLEF
1423-0127-17-82-1.jpg
Transgenic mouse genotyping using multiplex allele-specific PCR and melting curve analysis . PCR was performed in an optical cycler (ABI 7300) using 1-10 ng genomic DNA from mice of the indicated genotypes and a reagent mix containing SYBR GreenER. Amplification plots (A, C) and melting curves (B, D) are shown. Primers...
true
ImageCLEF
1423-0127-17-88-5.jpg
Flow cytometry analysis to determine the number of E7-specific CD8+ T cells in the tumor-infiltrating lymphocytes of mice vaccinated subcutaneously or intratumorally . The TC-1 tumor-bearing C57BL/6 mice (5 per group) were immunized subcutaneously or intratumorally using a combination of 20 μ g/mouse of HPV-16 E7 (aa ...
true
ImageCLEF
1423-0127-17-9-3.jpg
The number of TH-positive cells was evaluated at four weeks after 6-OHDA lesioning . Normal TH immunoreactivity was detected in the substantia nigra (A) and striatum (C) of all the sham animals. Depletion of TH immunoreactivity was noted in the substantia nigra (B) and striatum (D) at the side treated with 6-OHDA. Immu...
true
ImageCLEF
1423-0127-17-90-5.jpg
Midpoint potential measurement of HLMW b 5 with spectroelectrochemical titration . Spectroelectrochemical titration was conducted by recording the absorption spectrum of HLMW b 5 (15 μ M in 50 mM sodium phosphate buffer pH 7.0) at various redox potentials by the addition of sodium dithionite to the oxidized form at ...
true
ImageCLEF
1423-0127-17-91-1.jpg
GLUT1 immunostaining in normal mice . Cortex immunostaining: cells within layers I to IV exhibit a cytoplasmic staining. The staining is presented as follows: A: Alexa 488 signals (green) for GLUT1. The arrow indicates an example of stained cell; B: Hoecsht signals (blue) for the nuclear counterstaining; C: Alexa 488 s...
true
ImageCLEF
1423-0127-17-91-2.jpg
PiT2 immunostaining in normal mice . A: PiT2 immunostaining in the cortex of a normal mouse. In this representative image, the staining is detected in all cortical layers, with a "rosette like" aspect. The arrow indicates a characteristic stained neuron displayed in the enlarged inset (magnification x300). B: PiT2 immu...
true
ImageCLEF
1423-0127-17-S1-S16-5.jpg
Effects of 3-AB, NIC and TAU on plasma (A) total cholesterol and (B) triglycerides of diabetic rats. Data are presented as mean ± S.E.M. for n = 6. Statistical comparisons were significantly different at **P < 0.01 and ***P < 0.001 vs. Control; at + P < 0.05, ++ P < 0.01 and +++ P < 0.001 vs. STZ; and at ° P < 0...
true
ImageCLEF
1423-0127-17-S1-S44-5.jpg
Effects of cholate and Calculus bovis on beating of cardiac myocytes. Cardiomyocytes were exposed to medium containing CA or C.Bovis -extract for 3 h. The morphological changes (A) and beating status (B), untreated cells, (a, d); CA 0.5 mM, (b, e); C.Bovis -extract 1x10 -1 mg/ml, (c, f)
true
ImageCLEF
1423-0127-17-S1-S47-2.jpg
Inverse correlations between urinary K excretion and dyslipidemic risk in Japanese adolescent girls . The participants who had successfully collected 24-h urine were divided into higher (n = 105) and lower (n = 107) groups at a median of urinary K excretion. (A) Serum triglyceride level and (B) Serum HDL level were mea...
true
ImageCLEF
1423-0127-17-S1-S47-3.jpg
Inverse correlations between urinary taurine excretion and dyslipidemic risk in Japanese adolescent girls . The participants who had successfully collected 24-h urine were divided into higher (n = 106) and lower groups (n = 106) at a median of urinary taurine excretion. (A) Serum triglyceride level, (B) plasma insulin ...
true
ImageCLEF
1423-0127-18-14-2.jpg
The effect of Scutellaria Radix on SOD and catalase activities and MDA levels in the brain tissue . (A) SOD and catalase activities, (B) MDA levels in hippocampus tissues. Values are expressed as mean ± standard deviation (mean ± S.D.), and analyzed by one-way ANOVA and multiple comparisons were performed by Tukey ...
true
ImageCLEF
1423-0127-18-21-3.jpg
Characterization of the E7-specific CD8+ T cell immune responses in na ï ve mice treated with HPV-16 E7 DNA vaccine in combination with DMXAA administered at different time points . (A) Schematic diagram of the immunization regimen of the CRT/E7 DNA vaccine and/or DMXAA administered at different time points, either 3...
true
ImageCLEF
1423-0127-18-21-4.jpg
Characterization of the E7-specific CD8+ T cell immune responses in tumor-bearing mice treated with HPV-16 E7 DNA vaccine in combination with DMXAA administered at different time points . (A) Schematic diagram of the immunization regimen of the CRT/E7 DNA vaccine and/or DMXAA administered at different time points, ei...
true
ImageCLEF
1423-0127-18-21-6.jpg
Characterization of the E7-specific memory CD8+ T cell immune responses in mice treated with HPV-16 E7 DNA vaccine in combination with DMXAA . (A) Schematic diagram of the immunization regimen of the CRT/E7 DNA vaccine and/or DMXAA. 5-8 weeks old C57BL/6 mice were vaccinated with pcDNA3-CRT/E7 DNA vaccine via gene gu...
true
ImageCLEF
1423-0127-18-23-4.jpg
Current unified model of mRNA decay pathways in Escherichia coli . (A) Schematic representation of major enzymatic steps involved in the disintegration and complete turnover of primary transcripts in E. coli . The decay of a regular transcript is usually initiated by endonucleolytic cleavage to generate primary decay...
true
ImageCLEF
1423-0127-18-28-3.jpg
Aciculatin suppresses the increase of mRNA and protein expression and promoter activity of LPS-induced iNOS and COX-2 in macrophages . A. 1 × 10 6 RAW264.7 cells were treated with aciculatin (1-10 μ M) for 30 min, then stimulated with LPS (1 μ g/mL) for 5 h, mRNA of iNOS and COX-2 were measured by RT-PCR. B. T...
true
ImageCLEF
1423-0127-18-29-6.jpg
Effects of basic residue mutation in NDUFV2 MTS on mitochondrial targeting . (a) The sites of basic residue in NDUFV2 N-terminal 1-32 amino acids were underlined and marked. (b) The effect of basic residue mutation within the N-terminal region of NDUFV2 on mitochondrial targeting was evaluated by confocal image analyse...
true
ImageCLEF
1423-0127-18-29-8.jpg
The human pathogenic NDUFV2 deletion mutant lost most of its mitochondrial targeting ability . (a) Schematic representation of the genomic structure of NDUFV2 in the first three exons. The 4-bp deletion of human pathogenic IVS2+5_+8delGTAA mutation is indicated by underlined red letters (GTAA). Dotted line represents t...
true
ImageCLEF
1423-0127-18-30-1.jpg
Chemical structure of salvianolic acid A (Sal A) and Sal B . More than eighteen components can be identified in Radix S. miltiorrhiza . Sal B is the most abundant while Sal A is the most potent water-soluble phenolic component in Radix S. miltiorrhiza .
true
ImageCLEF
1423-0127-18-32-6.jpg
Co-localization of PKA and nNOS proteins in NTS . Confocal microscopic images of NTS showing immunofluorescence staining for nNOS (A, Alexa Fluor 546), PKA (B, Alexa Fluor 488), or cell nuclei (C, DAPI). The merged image (D) showing single staining for PKA (arrowhead) or double immunofluorescence staining (yellow color...
true
ImageCLEF
1423-0127-18-4-3.jpg
Global analysis of the apoE3-(72-166) proteins in PBS (pH 7.3) . The SV experiment (A) was centrifuged to 42,000 rpm (circles) at 20 ° C for 4 h. The speed of centrofugation for SE experiments (B) was 10,000 rpm (circles), 15,000 rpm (triangles), and 20,000 rpm (squares) at 20 ° C each for 18 h. The solid lines in A-B ...
true
ImageCLEF
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MedPMC Multipanel Figure Detection Training/Test Datasets

Overview

This dataset contains the annotations used for the multipanel figure detection stage of the MedPMC framework. The task is to identify whether a biomedical figure is a multipanel, or compound, figure. This stage supports downstream subfigure extraction and caption alignment by separating figures that contain multiple visual panels from standalone figures. The training and validation sets combine GPT-4o–annotated PMC figures (source == "PMC_synthetic") and data derived from the ImageCLEF 2016 medical task (source == "ImageCLEF"). The test set consists of 1,615 ImageCLEF samples and 500 manually annotated PMC figures. For details on dataset construction, annotation guidelines, and the overall MedPMC pipeline, please refer to our paper.

Dataset Statistics

Split Samples
Train 56,135
Validation 13,991
Test 3,956

Dataset Features

Field Description
image Figure image
image_id Unique image identifier
caption Figure caption
is_multipanel Binary label indicating whether the figure is a multipanel figure
source Source dataset or annotation subset from which the sample was derived

Label Definition

A figure is labeled as is_multipanel = true if it contains multiple visually distinct panels, subfigures, or components within a single figure image. These figures often include panel labels such as A, B, C, or D, or otherwise present multiple image regions, plots, diagrams, or visual elements intended to be interpreted as separate panels.

A figure is labeled as is_multipanel = false if it is a standalone figure without clearly separated visual panels.

Quick Start

Load the Dataset

from datasets import load_dataset

dataset = load_dataset("Yale-BIDS-Chen/medpmc-multi-fig-detection-dataset")

print(dataset)

Citation

If you use this dataset, please cite:

Citation information will be updated soon.

Part of this dataset is derived from the ImageCLEF 2016 medical task dataset. Please also cite the original ImageCLEF dataset and associated publication:

@InProceedings{GSB2016,

Title = {Overview of the {ImageCLEF} 2016 medical task},
Author = {Garc\'ia Seco de Herrera, Alba and Schaer, Roger and Bromuri, Stefano and M\"uller, Henning },
Booktitle = {Working Notes of {CLEF} 2016 (Cross Language Evaluation Forum)},
Year = {2016},
Month = {September},
Location = {\'Evora, Portugal}
}

License and usage

This dataset is distributed under CC BY-NC-SA 4.0 for non-commercial research use. Users are responsible for complying with the licenses and terms.

Questions?

For questions or feedback, please contact Hyunjae Kim at hyunjae.kim@yale.edu.

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