source_symbol stringlengths 2 10 | target_symbol stringlengths 2 10 | class int64 0 1 | source_summary stringlengths 85 2.46k | target_summary stringlengths 85 2.46k | source_wikipedia stringlengths 27 93.9k | target_wikipedia stringlengths 27 93.9k | source_wikicrow stringlengths 2.08k 18.3k | target_wikicrow stringlengths 2.08k 20.9k |
|---|---|---|---|---|---|---|---|---|
FZR1 | ELMO2 | 0 | Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic G2 DNA damage checkpoint signaling; and positive regulation of protein metabolic process. Located in nuclear membrane and nucleoplasm. Colo... | The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] | Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene. Interactions FZR1 has been shown to interact with CDC27 and FBXO5. References Further reading External links Overview of all the structural information available in the PDB for UniProt: Q9UM11 (Fizzy-related p... | Engulfment and cell motility protein 2 is a protein that in humans is encoded by the ELMO2 gene. The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. A... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== FZR1 is a gene that encodes the protein fizzy and cell division cycle 20 related 1, commonly referred to as FZR1 or CDH1. This protein is a regulatory component of the anaphase-promoting complex/cyclosome (APC/C), a ... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== ELMO2 (Engulfment and Cell Motility 2) is a gene that encodes a scaffold protein involved in various cellular processes, including cell motility, polarity, and microtubule dynamics. The ELMO2 protein is characterized... |
TCEA1 | RPA2 | 1 | Predicted to enable DNA binding activity; translation elongation factor activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templat... | This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellula... | Transcription elongation factor A protein 1 is a protein that in humans is encoded by the TCEA1 gene. In other organisms, this gene is better known as transcription elongation factor II S (TFIIS). It mainly helps to resolve backtracked elongation complexes by inducing a cut in the RNAP active site, so reaction becomes ... | Replication protein A 32 kDa subunit is a protein that in humans is encoded by the RPA2 gene. Interactions RPA2 has been shown to interact with: See also Single-stranded binding protein Replication protein A Replication protein A1 Replication protein A3 References == Further reading == | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== TCEA1 is a gene that encodes the transcription elongation factor A1, a protein integral to the transcription process by RNA polymerase II. This protein is categorized as a transcription factor and plays a pivotal rol... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== RPA2 is a gene that encodes the replication protein A2, a critical component of the heterotrimeric replication protein A (RPA) complex. This complex is essential for DNA metabolism, including replication, repair, rec... |
FNIP1 | PYCARD | 0 | This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related ... | This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large sign... | Folliculin-interacting protein 1 (FNIP1) functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. FNIP1 acts as a scaffold to load FLCN onto Hsp90. FNIP1 is also involved in chaperoning of both kinase and non-kinase clients. Co-c... | PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene. It is localized mainly in the nucleus of monocytes and macrophages. In case of pathogen infection, however, it relocalizes rapidly to the cytoplasm, perinuclear space,... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== Folliculin interacting protein 1 (FNIP1) is a gene that encodes a protein of the same name, which plays a pivotal role in cellular energy homeostasis and metabolism. The FNIP1 protein is primarily involved in the reg... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== PYCARD is a gene that encodes the protein ASC (Apoptosis-associated Speck-like protein containing a CARD), which is integral to the regulation of apoptosis and inflammation. The ASC protein is characterized by its tw... |
UBC | UBE2B | 1 | This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repa... | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. Th... | The University of British Columbia (UBC) is a public research university with campuses near Vancouver and Kelowna, in British Columbia, Canada. Established in 1908, it is the oldest university in British Columbia and oldest Canadian university west of Winnipeg. With an annual research budget of $893 million, UBC funds ... | Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzym... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== The UBC gene encodes the ubiquitin C protein, a pivotal component of the ubiquitin-proteasome system, which is integral to protein degradation and cellular regulation. Ubiquitin C is a small, highly conserved protein... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== UBE2B is a gene that encodes the ubiquitin-conjugating enzyme E2 B, a critical component of the ubiquitin-proteasome system. This enzyme is involved in the post-translational modification of proteins through ubiquiti... |
IL2RA | UBE2D1 | 0 | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integra... | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. Th... | The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with interleukin-2, a ple... | Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene. Function The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-acti... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== The IL2RA gene encodes the interleukin-2 receptor subunit alpha (CD25), a critical component of the high-affinity interleukin-2 (IL-2) receptor complex, which plays a pivotal role in the immune system. This receptor ... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== UBE2D1 is a gene that encodes the ubiquitin-conjugating enzyme E2 D1, a crucial component of the ubiquitination pathway, which is involved in protein degradation and regulation within cells. As a member of the E2 enz... |
BRAF | MARK3 | 1 | This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identi... | The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] | BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B, while the protein is more formally known as serine/threonine-protein kinase B-Raf. The B-Raf protein is involved in sending signals inside cells which are inv... | MAP/microtubule affinity-regulating kinase 3 is an enzyme that in humans is encoded by the MARK3 gene. Interactions MARK3 has been shown to interact with Stratifin. It has been linked to a form of genetic blindness, believed to be a genetic recessive disease that progressively destroys the eyes. References == Furt... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== The BRAF gene encodes the B-Raf proto-oncogene, a serine/threonine kinase that plays a pivotal role in the mitogen-activated protein kinase (MAPK) signaling pathway, specifically within the Ras-RAF-MEK-ERK cascade. T... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== MARK3, or microtubule affinity-regulating kinase 3, is a gene that encodes a serine/threonine kinase involved in the regulation of microtubule dynamics and cell polarity. The protein product of MARK3, also known as C... |
MGA | EBNA1BP2 | 0 | Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of... | Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022] | MGA, MAX dimerization protein is a protein that in humans is encoded by the MGA gene. References == Further reading == | Probable rRNA-processing protein EBP2 is a protein that in humans is encoded by the EBNA1BP2 gene. Interactions EBNA1BP2 has been shown to interact with FGF3. References == Further reading == | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== MGA (MAX dimerization protein MGA) is a gene that encodes a transcription factor involved in the regulation of gene expression, particularly in the context of cellular differentiation and development. The protein pro... | Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ======== EBNA1BP2 is a gene that encodes the EBNA1 binding protein 2, a nucleolar protein involved in various cellular processes, including ribosome biogenesis and mRNA maturation. The protein is known for its interactions wi... |
SEMA4D | ARHGEF11 | 1 | "Enables identical protein binding activity; semaphorin receptor binding activity; and transmembrane(...TRUNCATED) | "Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellu(...TRUNCATED) | "Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the se(...TRUNCATED) | "Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 ge(...TRUNCATED) | "Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ====(...TRUNCATED) | "Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ====(...TRUNCATED) |
KDM6A | CAB39 | 0 | "This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which en(...TRUNCATED) | "Enables kinase binding activity and protein serine/threonine kinase activator activity. Involved in(...TRUNCATED) | "Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X c(...TRUNCATED) | "Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene. The protein en(...TRUNCATED) | "Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ====(...TRUNCATED) | "Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ====(...TRUNCATED) |
RB1 | E2F3 | 1 | "The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor (...TRUNCATED) | "This gene encodes a member of a small family of transcription factors that function through binding(...TRUNCATED) | "The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1(...TRUNCATED) | "Transcription factor E2F3 is a protein that in humans is encoded by the E2F3 gene. Function The pr(...TRUNCATED) | "Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ====(...TRUNCATED) | "Info ==== Gene Position (hg19) ==================== Related Genes ============= Overview ====(...TRUNCATED) |
End of preview. Expand in Data Studio
README.md exists but content is empty.
- Downloads last month
- 2