annotation_id int64 1 12 | annotator int64 1 1 | created_at stringlengths 27 27 | id int64 1 12 | label stringlengths 1.07k 5.65k | lead_time float64 286 262k | text stringlengths 8.08k 21.5k | updated_at stringlengths 27 27 |
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1 | 1 | 2025-09-18T09:14:33.602208Z | 1 | [{"start":16663,"end":16674,"text":"lymphocytes","labels":["CellType"]},{"start":6272,"end":6277,"text":"PBMCs","labels":["CellType"]},{"start":9860,"end":9865,"text":"PBMCs","labels":["CellType"]},{"start":10554,"end":10559,"text":"PBMCs","labels":["CellType"]},{"start":11028,"end":11033,"text":"PBMCs","labels":["Cell... | 1,152.703 | Introduction The persistence of replication-competent, but transcriptionally inhibited HIV-1 proviral DNA in long-lived, latent cellular reservoirs is a significant barrier to the development of a functional cure [1,2] Even after long-term, suppressive antiretroviral therapy (ART), spontaneous reactivation of proviral ... | 2025-09-19T10:27:00.943310Z |
2 | 1 | 2025-09-18T09:14:33.602342Z | 2 | [{"start":449,"end":463,"text":"HeLa cell line","labels":["CellLine"]},{"start":5062,"end":5079,"text":"Jurkat 2D10 cells","labels":["CellLine"]},{"start":4027,"end":4047,"text":"primary CD4+ T cells","labels":["InVitroPrimaryCell"]},{"start":5219,"end":5231,"text":"CD4+ T cells","labels":["CellType"]},{"start":418,"en... | 1,278.895 | Results Dcas9-targeted hiv-1 ltr-interactome analysis identified prmt3 as a ltr-binding factor Seeking host factors that specifically associate with the HIV-1 LTR, we conducted an LTR-interacted proteome analysis based on a refined version of a previously described nuclease-deficient Cas9 (dCas9)-targeted chromatin-bas... | 2025-09-19T10:27:44.193443Z |
3 | 1 | 2025-09-18T09:14:33.602565Z | 3 | [{"start":180,"end":190,"text":"HeLa cells","labels":["CellLine"]},{"start":609,"end":619,"text":"HeLa cells","labels":["CellLine"]},{"start":2189,"end":2199,"text":"HeLa cells","labels":["CellLine"]},{"start":3080,"end":3090,"text":"HeLa cells","labels":["CellLine"]},{"start":4396,"end":4406,"text":"HeLa cells","label... | 1,428.181 | Methods The cytotoxic effects of the A. incana DCM fraction were evaluated in a dose-dependent manner using the MTT assay on several cancer cell lines, with particular emphasis on HeLa cells. Flow cytometry was used to assess cell cycle arrest and apoptosis, while RT-qPCR quantified changes in the expression of apoptot... | 2025-09-19T10:28:32.559073Z |
4 | 1 | 2025-09-18T09:14:33.602726Z | 4 | [{"start":3403,"end":3442,"text":"HIV-infected Jurkat-derived T cell line","labels":["CellLine"]},{"start":415,"end":442,"text":"memory-resting CD4+ T cells","labels":["CellType"]},{"start":1058,"end":1086,"text":"dormant HIV-infected T cells","labels":["CellType"]},{"start":1959,"end":1974,"text":"infected T cell","la... | 2,644.033 | Introduction The introduction of antiretroviral therapy (ART) has successfully limited the spread of Human Immunodeficiency Virus (HIV) and improved patient clinical outcomes. However, a complete cure for HIV infection remains out of reach, as the transcriptionally silent but replication-competent provirus that is inte... | 2025-09-23T11:41:58.629944Z |
5 | 1 | 2025-09-18T09:14:33.602884Z | 5 | [{"start":10297,"end":10308,"text":"splenocytes","labels":["CellType"]},{"start":10836,"end":10847,"text":"splenocytes","labels":["CellType"]},{"start":6151,"end":6191,"text":"CD4+ T cell line models of HIV-1 latency","labels":["CellLine"]},{"start":6624,"end":6636,"text":"T cell lines","labels":["CellLine"]},{"start":... | 3,095.487 | Introduction Antiretroviral therapy (ART) has been highly effective at suppressing human immunodeficiency virus (HIV) replication, thus significantly reducing disease progression and mortality in infected individuals. However, ART is not curative and does not meaningfully impact persistent viral reservoirs (VRs) of lat... | 2025-09-23T11:46:44.468234Z |
6 | 1 | 2025-09-18T09:14:33.603081Z | 6 | [{"start":1396,"end":1405,"text":"NCI-H1299","labels":["CellLine"]},{"start":1602,"end":1617,"text":"NCI-H1299 cells","labels":["CellLine"]},{"start":3264,"end":3273,"text":"NCI-H1299","labels":["CellLine"]},{"start":5137,"end":5146,"text":"NCI-H1299","labels":["CellLine"]},{"start":5591,"end":5606,"text":"NCI-H1299 ce... | 6,390.476 | Materials and methods Statistical analysis The data were described as mean ± standard deviation (SD) and the statistical significance was determined by one-way ANOVA before LSD test for multiple comparisons and independent-sample t-test for comparison between the two groups. The level of p ***Results*** Discussion The ... | 2025-09-19T12:14:00.590887Z |
7 | 1 | 2025-09-18T09:14:33.603373Z | 7 | [{"start":1092,"end":1099,"text":"neurons","labels":["CellType"]},{"start":8719,"end":8730,"text":"neutrophils","labels":["CellType"]},{"start":1793,"end":1805,"text":"HEK293 cells","labels":["CellLine"]},{"start":2471,"end":2477,"text":"HEK293","labels":["CellLine"]},{"start":3266,"end":3272,"text":"HEK293","labels":[... | 261,568.989 | 2. results 3. discussion Cell surface receptors and their coupled intracellular signaling pathways have been intensively studied in many physiological and pathological processes over five decades. Due to the critical feature of these receptor-mediated signaling in promoting malignant proliferation, invasion, and metast... | 2025-09-23T11:51:44.173489Z |
8 | 1 | 2025-09-18T09:14:33.603471Z | 8 | [{"start":8299,"end":8310,"text":"NSCLC cells","labels":["CellType"]},{"start":10874,"end":10885,"text":"NSCLC cells","labels":["CellType"]},{"start":11309,"end":11320,"text":"NSCLC cells","labels":["CellType"]},{"start":668,"end":678,"text":"A549 cells","labels":["CellLine"]},{"start":2501,"end":2511,"text":"A549 cell... | 286.076 | Results IFN-γ significantly induced STAT1 phosphorylation, leading to a time-dependent upregulation of PD-L1 expression. Immunofluorescence confirmed that p-STAT1 is translocated to nucleus. Curcumin treatment inhibited STAT1 phosphorylation by 68% (p p ***Conclusion*** Curcumin effectively inhibits IFN-γ-induced STAT1... | 2025-09-22T13:46:32.762897Z |
9 | 1 | 2025-09-18T09:14:33.603605Z | 9 | [{"start":920,"end":936,"text":"cell line MIO-M1","labels":["CellLine"]},{"start":5334,"end":5351,"text":"retinal microglia","labels":["CellType"]},{"start":5634,"end":5660,"text":"inner blood-retina barrier","labels":["Tissue"]},{"start":2285,"end":2300,"text":"retinal tissues","labels":["Tissue"]},{"start":5792,"end"... | 7,366.209 | Materials and methods Statistical analysis All experiments were performed at least three times. A one-way ANOVA followed by a Tukey's post-hoc test was used to compare the RT-qPCR signals from the treated cells and the ELISA results. For comparison of RT-qPCR signals from treated cells to the hypothetical value of 1 (n... | 2025-09-22T16:13:48.125477Z |
10 | 1 | 2025-09-18T09:14:33.603847Z | 10 | [{"start":1969,"end":1979,"text":"HeLa cells","labels":["CellLine"]},{"start":2255,"end":2265,"text":"HeLa cells","labels":["CellLine"]},{"start":2344,"end":2348,"text":"HeLa","labels":["CellLine"]},{"start":2495,"end":2505,"text":"HeLa cells","labels":["CellLine"]},{"start":2582,"end":2591,"text":"HeLa cell","labels":... | 5,727.084 | 2. results 3. discussion Conifer bark, the medicinal use of which dates back more than 2000 years, contains bioactive alkaloids, flavonoids, lignans, phenolic acids, proanthocyanidins, stilbenes, and terpenoids that contribute to its therapeutic potential. Various conifer bark extracts are used nowadays in the nutraceu... | 2025-09-22T18:17:46.605439Z |
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OTAR3088 ChEMBL assay descriptions raw data
_TSV file containing all articles annotated in LabelStudio. These are considered the raw outputs of curation carried out for this data.
The following EuropePMC articles were annotated here:
- PMC12105127
- PMC11075828
- PMC11699618
- PMC12101583
- PMC12072392
- PMC12141184
- PMC10442740
- PMC12115102
- PMC11641291
- PMC12118871
- PMC11419360
- PMC12081701
Annotations were completed in alignment with the following annotation guidelines: https://github.com/EuropePMC/OTAR3088/blob/main/docs/annotation_guidelines.md
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