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8ba395114162_0 | 8ba395114162 | 0 | Title: Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity
Passage: successful treatment for HCV serves to circumvent the viral inhibition of IFN induction. Thus, HCV may be an example of a medically relevant persistent viral infe... |
77fccf45d903_0 | 77fccf45d903 | 1 | Title: Type I Interferon Response Is Delayed in Human Astrovirus Infections
Passage: Results suggest that HAstV infection is not able to disrupt the innate immune sensing pathway induced by polyI:C . Only a previous infection with RV was able to reduce by 60% the IFN-β mRNA levels produced after polyI:C transfection, a... |
9ae57afb9180_0 | 9ae57afb9180 | 2 | Title: UNC93B1 Mediates Innate Inflammation and Antiviral Defense in the Liver during Acute Murine Cytomegalovirus Infection
Passage: 4-fold fewer PDCA-1+ pDCs expressing intracellular IFN-a at 40 h, and 3-fold fewer at 48 h post-infection, in 3d mice as compared to WT . This trend was also reflected in the proportion ... |
c18cd003d80f_0 | c18cd003d80f | 3 | Title: Immune Mechanisms Responsible for Vaccination against and Clearance of Mucosal and Lymphatic Norovirus Infection
Passage: HuNV infection and disease is rapid, with symptoms developing within 24-48 hours of infection and lasting for a few days. Thus, we selected three days after challenge as a readout for infecti... |
bdba9047b034_0 | bdba9047b034 | 4 | Title: First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020
Passage: A cluster of pneumonia of unknown origin was identified in Wuhan, China, in December 2019 . On 12 January 2020, Chinese authorities shared the sequence of a novel coronavirus termed severe acute... |
00859c313dcb_0 | 00859c313dcb | 5 | Title: First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020
Passage: Text: In the WHO European Region, COVID-19 surveillance was implemented 27 January 2020. We detail the first European cases. As at 21 February, nine European countries reported 47 cases. Among 3... |
3642cc3f9a55_0 | 3642cc3f9a55 | 6 | Title: First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020
Passage: Abstract: In the WHO European Region, COVID-19 surveillance was implemented 27 January 2020. We detail the first European cases. As at 21 February, nine European countries reported 47 cases. Amo... |
9929d17af28b_0 | 9929d17af28b | 7 | Title: First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020
Passage: All of the imported cases had a history of travel to China. This was consistent with the epidemiological situation in Asia, and supported the recommendation for testing of suspected cases with t... |
7b2e2fc8e311_0 | 7b2e2fc8e311 | 8 | Title: Development of an ELISA-array for simultaneous detection of five encephalitis viruses
Passage: Antibody arrays for simultaneous multiple antigen quantification are considered the most accurate methods . Liew validated one multiplex ELISA for the detection of 9 antigens; Anderson used microarray ELISA for multipl... |
ea410fa58631_0 | ea410fa58631 | 9 | Title: Development of an ELISA-array for simultaneous detection of five encephalitis viruses
Passage: for printing than for coating ELISA plates. Coating of a single well in microtiter plate requires 100 μl of a 1 μg/ml antibody solution, which is equivalent to 100 ng of IgG. For the ELISA-array, only 30 nl of a 50 μg/... |
de840d32328a_0 | de840d32328a | 10 | Title: Development of an ELISA-array for simultaneous detection of five encephalitis viruses
Passage: antibodies demonstrated that 0.05 mg/ml was also suitable. |
99d53e46f353_0 | 99d53e46f353 | 11 | Title: Development of an ELISA-array for simultaneous detection of five encephalitis viruses
Passage: Antigen binding was performed in PBS at 37°C for 2 h, followed by washing 3 times. Incubation of ELISA plates with biotinylated detecting antibody cocktails was performed in PBS at 37°C for 2 h. After washing, specific... |
d85892ed42ba_0 | d85892ed42ba | 12 | Title: Vaccines and Therapeutics Against Hantaviruses
Passage: The diameter of hantavirus particles is 80-US210 nm, and the structure is spherical or ovoid. They are composed of 20-30% fat, >50% protein, 7% carbohydrates, and 2% RNA. They are very stable and can survive for more than 18 days at 4 • C and −20 • C and 10... |
2fdf271b25ed_0 | 2fdf271b25ed | 13 | Title: Vaccines and Therapeutics Against Hantaviruses
Passage: glycoprotein, which mediates the recognition of and entry into host cells. The crystal structure of HTNV Gn is very similar to that of PUUV Gn, which confirms that hantavirus Gn is conserved in hantavirus . |
ba9705056a76_0 | ba9705056a76 | 14 | Title: Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France
Passage: negative polarity: S segment codes for the nucleocapsid protein and a small non-structural s protein in several viral species; M segment for the glycoprotein precursor of the envelope glycoproteins Gn and Gc; and L segmen... |
186b5b6e58d6_0 | 186b5b6e58d6 | 15 | Title: Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/K(b) Transgenic Mice May Associate with the Severity of Hemorrhagic Fever with Renal Syndrome
Passage: Hantaan virus antigens in the supernatants of the tissue sam... |
a165849de4a9_0 | a165849de4a9 | 16 | Title: Estimating the number of infections and the impact of non-
Passage: countries between 7 and 43 million individuals have been infected with SARS-CoV-Z up to 28th March, |
c432d7339a95_0 | c432d7339a95 | 17 | Title: SARS to novel coronavirus – old lessons and new lessons
Passage: According to the situation report published by the WHO on 28 January 2020 , a total of 2798 confirmed 2019-nCoV cases have been reported globally; of these, 2761 cases were from China, including Hong Kong , Macau and Taipei . Thirty-seven confirmed... |
a6758be54bc1_0 | a6758be54bc1 | 18 | Title: Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Passage: SARS-CoV and MERS-CoV cause severe disease, but despite the initial R0 estimations of greater than 2.0 for SARS-CoV , and some large outbreaks, neither were as transmissible as initial concerns suggested. SARS-CoV caused 8098 repo... |
bfbe59bf67b3_0 | bfbe59bf67b3 | 19 | Title: Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus
Passage: in Toronto, Canada, a single importation is thought to have led to about 400 cases and 44 deaths. Later estimates of R0 were less than 1, indicating that SARS-CoV may not have been capable of sustained transmission, especially in ... |
71f316a5d9bb_0 | 71f316a5d9bb | 20 | Title: Community responses to communication campaigns for influenza A (H1N1): a focus group study
Passage: The analysis of the focus group data was undertaken by a single researcher who was neither present at the focus groups nor had read any preliminary findings. This work was verified by the focus group facilitators ... |
3a40df1319d0_0 | 3a40df1319d0 | 21 | Title: Community responses to communication campaigns for influenza A (H1N1): a focus group study
Passage: The primary objective of this study was to provide health authorities with evidence-based practical information to guide the development and delivery of key health messages for H1N1 and other health campaigns. The... |
7a8c23e08b3a_0 | 7a8c23e08b3a | 22 | Title: Community responses to communication campaigns for influenza A (H1N1): a focus group study
Passage: The study was part of a rapid response initiative; therefore focus groups were selected as the most efficient means of data collection in the time available. Eight semi-structured focus groups were recruited betwe... |
64b091ea6450_0 | 64b091ea6450 | 23 | Title: Community responses to communication campaigns for influenza A (H1N1): a focus group study
Passage: All focus group sessions were recorded and independently, professionally transcribed. Transcriptions were mainly verbatim, with verbal padding and hesitations omitted. Apart from the facilitators, specific individ... |
e4d2a2f1430a_0 | e4d2a2f1430a | 24 | Title: Patterns of Positive Selection in Six Mammalian Genomes
Passage: Since it first became possible to compare the sequences of complete mammalian genomes about five years ago, a number of genome-wide scans for positively selected genes have been conducted using phylogenetic methods . These studies have provided a v... |
9f76209f7279_0 | 9f76209f7279 | 25 | Title: Patterns of Positive Selection in Six Mammalian Genomes
Passage: particular patterns of positive selection that have helped to shape present-day genes. To our knowledge this is the largest and most detailed genome-wide analysis of positive selection to date, not only in mammals but in any group of organisms ). |
79f959b69797_0 | 79f959b69797 | 26 | Title: Patterns of Positive Selection in Six Mammalian Genomes
Passage: To accurately identify orthologous sequences in the six mammalian species, we used syntenic whole-genome alignments produced by the MULTIZ program on the following assemblies available through the UCSC genome browser : human , chimpanzee , macaque ... |
f83e42b59ac1_0 | f83e42b59ac1 | 27 | Title: Patterns of Positive Selection in Six Mammalian Genomes
Passage: For each gene cluster we have selected the transcript that has been successfully mapped to the largest number of species, using CDS length as a secondary criteria. This procedure resulted in 17,500 genes that were successfully mapped to at least tw... |
e31f4b9747f1_0 | e31f4b9747f1 | 28 | Title: Severe Measles Infection: The Spectrum of Disease in 36 Critically Ill Adult Patients
Passage: Acute respiratory distress syndrome was defined in compliance with the Berlin conference on ARDS. 69 Adjunctive therapies of ARDS including prone positioning, inhaled nitric oxide , and extracorporeal circulation membr... |
93a267d2bfa2_0 | 93a267d2bfa2 | 29 | Title: Severe imported malaria in an intensive care unit: a review of 59 cases
Passage: frequent in those who died. These data are in agreement with literature review, where the fatality rate is higher in cerebral malaria and acute respiratory distress syndrome . Two of the patients were put on ECMO, used as a rescue t... |
90fcea86bba1_0 | 90fcea86bba1 | 30 | Title: Clinical features and outcome of patients with acute respiratory failure revealing anti-synthetase or anti-MDA-5 dermato-pulmonary syndrome: a French multicenter retrospective study
Passage: Almost all patients had ARDS, categorized as severe in 86% , with 17% of them requiring ECMO. ICU and hospital mortality r... |
a6c21f8ce3c1_0 | a6c21f8ce3c1 | 31 | Title: 36th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 15-18 March 2016
Passage: Conclusions: Although MSF is generally considered a benign disease we had a high ICU admission rate and a considerable mortality rate. We found that the SAPS II score, the leukocytes count and aPTT... |
4e51c24a7995_0 | 4e51c24a7995 | 32 | Title: Hantaviruses in the Americas and Their Role as Emerging Pathogens
Passage: Testing models of pathogenesis can be done more effectively when there is an animal model that mimics key aspects of the disease. There is no such model that closely mimics HFRS, but animal models exist for both the asymptomatic carriage ... |
61ed5c043fae_0 | 61ed5c043fae | 33 | Title: The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus
Passage: virological examination of the trachea, lung, brain, heart, liver, spleen, kidney, stomach, intestine, and olfactory bulb. All nine animals were observed for clinical signs and weighed daily as an indicator of... |
9d95e8d71cf3_0 | 9d95e8d71cf3 | 34 | Title: Complete Genome and Phylogeny of Puumala Hantavirus Isolates Circulating in France
Passage: between the reservoir and the disease is not clearly elucidated . Among likely explanations, it could be that many NE cases remain undetected or misdiagnosed due to mild symptoms which possibly lead to confusion with othe... |
4bba8391c7fa_0 | 4bba8391c7fa | 35 | Title: The mouse and ferret models for studying the novel avian-origin human influenza A (H7N9) virus
Passage: the trachea, lung, brain, heart, liver, spleen, kidney, stomach, intestine, and olfactory bulb. All nine animals were observed for clinical signs and weighed daily as an indicator of disease. Nasal and throat ... |
a5b5c2c9d0fa_0 | a5b5c2c9d0fa | 36 | Title: A Phylogeny-Based Global Nomenclature System and Automated Annotation Tool for H1 Hemagglutinin Genes from Swine Influenza A Viruses
Passage: Clade designations for 1A swine lineage. The 1A lineage contained 1,889 viruses from 34 countries collected from 2010 to the present . According to our nomenclature rules,... |
ce8ee9212117_0 | ce8ee9212117 | 37 | Title: A Phylogeny-Based Global Nomenclature System and Automated Annotation Tool for H1 Hemagglutinin Genes from Swine Influenza A Viruses
Passage: Clade designations for 1C swine lineage. The 1C lineage consisted of 315 viruses from 14 countries collected from 2010 to the present in China and South Korea. Avian H1 HA... |
7a6b64932b70_0 | 7a6b64932b70 | 38 | Title: A Phylogeny-Based Global Nomenclature System and Automated Annotation Tool for H1 Hemagglutinin Genes from Swine Influenza A Viruses
Passage: The 1B human seasonal lineage within-and between-clade APDs are presented in Table 3 . For the most part, each clade had an APD of Ͼ7% from other clades and almost all had... |
ecae5db72cd1_0 | ecae5db72cd1 | 39 | Title: A Phylogeny-Based Global Nomenclature System and Automated Annotation Tool for H1 Hemagglutinin Genes from Swine Influenza A Viruses
Passage: were placed into seven clades. The numerically dominant clades reflected intensive surveillance in the United States , investigator sequencing efforts in Canada , and the ... |
6e44b589a0d7_0 | 6e44b589a0d7 | 40 | Title: Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
Passage: Bats have a suite of antiviral defenses that keep the amount of virus in check. For example, some bats have an antiviral immune response called the interferon pathway perpetually switched on. In most other mammals, ha... |
1f2dc2186fc7_0 | 1f2dc2186fc7 | 41 | Title: Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
Passage: The experiments made use of cells from one bat species -the black flying fox -in which the interferon pathway is always on, and another -the Egyptian fruit bat -in which this pathway is only activated during an infect... |
e0f58a835c60_0 | e0f58a835c60 | 42 | Title: Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
Passage: Recent research advances are beginning to shed light on the molecular mechanisms by which bats avoid pathology from these otherwise virulent pathogens . Bats leverage a suite of species-specific mechanisms to limit vi... |
14e04adbff7f_0 | 14e04adbff7f | 43 | Title: Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence
Passage: countered by the virus spreading more quickly from cell to cell. This suggests that bat immune defenses may drive the evolution of faster transmitting viruses, and while bats are well protected from the harmful effect... |
c7358f7a0936_0 | c7358f7a0936 | 44 | Title: Design, Synthesis, Evaluation and Thermodynamics of 1-Substituted Pyridylimidazo[1,5-a]Pyridine Derivatives as Cysteine Protease Inhibitors
Passage: Cysteine-protease inhibitors have gained considerable attention over the last couple of decades and many classes of compounds are currently in human clinical trials... |
0ba1bf0660f0_0 | 0ba1bf0660f0 | 45 | Title: Design, Synthesis, Evaluation and Thermodynamics of 1-Substituted Pyridylimidazo[1,5-a]Pyridine Derivatives as Cysteine Protease Inhibitors
Passage: In summary, the results of the present study have established that 1-substituted pyridylimidazopyridine derivatives could be candidate for novel and potent inhibito... |
abac519731de_0 | abac519731de | 46 | Title: Design, Synthesis, Evaluation and Thermodynamics of 1-Substituted Pyridylimidazo[1,5-a]Pyridine Derivatives as Cysteine Protease Inhibitors
Passage: Text: Cysteine-protease inhibitors have gained considerable attention over the last couple of decades and many classes of compounds are currently in human clinical ... |
a0f12cda87ad_0 | a0f12cda87ad | 47 | Title: Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets
Passage: the corners with Valap, and evaporation was allowed to occur through the edges over several hours. Slides were observed either with a confocal microscope or with a Nikon TE2000 inverted fluorescence microscope with a 100× oil objecti... |
a4522a16f2cb_0 | a4522a16f2cb | 48 | Title: Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets
Passage: to be: |
a981e2331e46_0 | a981e2331e46 | 49 | Title: Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets
Passage: coacervate samples with 5 µM 5′-6-FAM-labeled RNA 15-mer at room temperature in 100 mM Tris-Cl pH 8. On the left, the system clearly separates into two phases with the RNA in the bottom, complex-enriched phase. On the right, the syst... |
bf83d5185f16_0 | bf83d5185f16 | 50 | Title: Rapid RNA Exchange in Aqueous Two-Phase System and Coacervate Droplets
Passage: All imaging visualization, analysis, calculations, and production of movies were performed using FIJI . All curve fitting was performed using MATLAB . All figures were produced using Adobe Illustrator . |
87deb06c52b8_0 | 87deb06c52b8 | 51 | Title: Hantaviruses in the Americas and Their Role as Emerging Pathogens
Passage: cases of acute febrile disease with renal compromise were described from several Eurasian countries and Japan, often in association with military engagements . HFRS as a distinct syndrome, however, was first brought to the attention of we... |
59ad36b0ec4f_0 | 59ad36b0ec4f | 52 | Title: Vaccines and Therapeutics Against Hantaviruses
Passage: The initiation of careful observation and prompt but judicious supportive treatment is crucial to improve patient survival condition for both HFRS and HCPS . It has been demonstrated that admission to the ICU and supportive treatment could greatly reduce th... |
87a6c85f9de0_0 | 87a6c85f9de0 | 53 | Title: Vaccines and Therapeutics Against Hantaviruses
Passage: It is wildly accepted that HFRS and HCPS are caused by uncontrolled systemic inflammatory responses, in which multiple inflammatory cytokines, especially TNF-α, IL-8, and RANTES, contributed to disease progression ; however, immunoregulation treatment in HF... |
6111d7fca9ff_0 | 6111d7fca9ff | 54 | Title: Vaccines and Therapeutics Against Hantaviruses
Passage: in 22 HCPS patients . However, a double-blind clinical trial in Chile failed to observe a significantly improved outcome between methylprednisolone recipients and placebo recipients for HCPS. Similarly, another randomized prospective study did not show any ... |
f3247836415e_0 | f3247836415e | 55 | Title: Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold
Passage: of improved or altered binding, roughly mimicking the somatic evolution strategy of the immune system . However, other in vitro display systems, suc... |
32686a094152_0 | 32686a094152 | 56 | Title: Antibody Engineering for Pursuing a Healthier Future
Passage: Phage display technology has facilitated the production of protein libraries, which are formed with large numbers of phage particles displaying different molecules . Specific binder screening with biopanning allows the enrichment of the desired molecu... |
b6e7a5b9a651_0 | b6e7a5b9a651 | 57 | Title: Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold
Passage: In the mid-1980s, the principle of modifying the filamentous phage genome to display polypeptides as fusions to coat proteins on the virion surface ... |
c2de313e4b70_0 | c2de313e4b70 | 58 | Title: 1918 Influenza: the Mother of All Pandemics
Passage: 12. Reid AH, Fanning TG, Hultin JV, Taubenberger JK. Origin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene. |
75e9ddd230e0_0 | 75e9ddd230e0 | 59 | Title: The 1918 Influenza Pandemic: Looking Back, Looking Forward
Passage: finding, and it will be important for future work to reconcile the well-accepted idea that a 1918-like virus may have circulated in Europe and North America in the second half of the 19th century, with the notion that Madrid would have escaped t... |
2881e557a6e6_0 | 2881e557a6e6 | 60 | Title: 1918 Influenza: the Mother of All Pandemics
Passage: by the Same Virus? If So, How and Why? |
1365c2d398f7_0 | 1365c2d398f7 | 61 | Title: 1918 Influenza: the Mother of All Pandemics
Passage: Could a 1918-like Pandemic Appear Again? |
eda5a7d15908_0 | eda5a7d15908 | 62 | Title: Revision of clinical case definitions: influenza-like illness and severe acute respiratory infection
Passage: "An acute respiratory illness with a measured temperature of ≥ 38 °C and cough, with onset within the past 10 days". a Compared with corresponding definition published in 1999. 9 Box 2. Criteria previous... |
6aa18dfd6c95_0 | 6aa18dfd6c95 | 63 | Title: Revision of clinical case definitions: influenza-like illness and severe acute respiratory infection
Passage: viruses. For the detection of infections with influenza viruses in children younger than five years, it may be advisable to use a tailored case definition, e.g. one that uses a higher temperature cutoff ... |
5867095de7b7_0 | 5867095de7b7 | 64 | Title: Revision of clinical case definitions: influenza-like illness and severe acute respiratory infection
Passage: conducted before WHO's 2011 consultation, the most predictive symptoms of influenza were found to be cough, fatigue, fever and myalgia. 18, 19 As sore throat had been identified as a negative predictor o... |
d7c507d5fbab_0 | d7c507d5fbab | 65 | Title: Low usage of government healthcare facilities for acute respiratory infections in guatemala: implications for influenza surveillance
Passage: We found 323 persons 6-7%) who met the pneumonia case definition in the previous year. Almost all met the case definition with self-reported cough and difficulty breathing... |
5305645e9b54_0 | 5305645e9b54 | 66 | Title: MERS coronavirus: diagnostics, epidemiology and transmission
Passage: DCs, may be an occupational group with significantly higher incidence of seropositivity to MERS-CoV when animals have active MERS-CoV infections . Expanded virological investigations of African DCs may lead to more seropositive animals and geo... |
9ccf166172f1_0 | 9ccf166172f1 | 67 | Title: MERS coronavirus: diagnostics, epidemiology and transmission
Passage: donors and 300 selfidentified animal workers from the Jazan Region of the KSA during 2012 . Similarly, a study of four herdsmen in contact with an infected DC herd in Al-Ahsa, eight people who had intermittent contact with the herd, 30 veterin... |
31ddf7d572d5_0 | 31ddf7d572d5 | 68 | Title: Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
Passage: Among confirmed cases, only 25.2% were healthcare workers, whereas around 75% were non-healthcare workers. |
1e5577f47bc4_0 | 1e5577f47bc4 | 69 | Title: MERS coronavirus: diagnostics, epidemiology and transmission
Passage: As a group, HCWs comprised 16 % of MERS cases in the KSA and South Korea. It is apparent that the weekly proportion of infected HCWs increases alongside each steep rise in overall detections . In May 2013, the WHO published guidelines for IPC ... |
3c401ba8f4d0_0 | 3c401ba8f4d0 | 70 | Title: Virus-Vectored Influenza Virus Vaccines
Passage: consideration for human influenza vaccination. |
b5ea9c2bee84_0 | b5ea9c2bee84 | 71 | Title: Virus-Vectored Influenza Virus Vaccines
Passage: current limitations of influenza vaccines. |
c5c27b18a2b5_0 | c5c27b18a2b5 | 72 | Title: Virus-Vectored Influenza Virus Vaccines
Passage: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147686/ |
29f37cff1793_0 | 29f37cff1793 | 73 | Title: Virus-Vectored Influenza Virus Vaccines
Passage: approaches. |
1483793c636a_0 | 1483793c636a | 74 | Title: Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold
Passage: phage populations in tandem with the relative abundance of free-living heterotrophic bacteria . Environmental metagenomics efforts are just beginnin... |
d008f289bdf0_0 | d008f289bdf0 | 75 | Title: Beyond phage display: non-traditional applications of the filamentous bacteriophage as a vaccine carrier, therapeutic biologic, and bioconjugation scaffold
Passage: effects upon their bacterial hosts that may not result in the development of resistance to infection. Several studies have reported increased antibi... |
907889ff4947_0 | 907889ff4947 | 76 | Title: Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory
Passage: ere is no specific treatment for MERS-CoV. Like most viral infections, the treatment options are supportive and symptomatic . At present,... |
7d4cf4aaa990_0 | 7d4cf4aaa990 | 77 | Title: Overview of the 3rd isirv-Antiviral Group Conference – advances in clinical management
Passage: Various therapeutic options have been investigated for the treatment of MERS-CoV, but no therapy of proven value currently exists. The use of SC was associated with adverse outcome in SARS 69 and is not recommended fo... |
e007891c7a68_0 | e007891c7a68 | 78 | Title: 2019-nCoV: The Identify-Isolate-Inform (3I) Tool Applied to a Novel Emerging Coronavirus
Passage: Supportive care with appropriate infection control is the mainstay of current CDC treatment guidelines for 2019-nCoV. There are not yet any approved antiviral treatments for 2019-nCoV. Emergency Use Authorizations f... |
d95b46e6f488_0 | d95b46e6f488 | 79 | Title: Host resilience to emerging coronaviruses
Passage: The current treatment and prevention options for SARS-CoV and MERS-CoV are limited. So far there are no licensed vaccines for SAR-CoV or MERS-CoV, although several strategies have been tried in animal models . There are also no antiviral strategies that are clea... |
fa42e5a97b5d_0 | fa42e5a97b5d | 80 | Title: Current and Novel Approaches in Influenza Management
Passage: LAIV viruses in the nasopharynx elicit immune response that epitomizes a natural influenza infection. For this reason, LAIV has shown some superiority over the IIV in terms of the induction of mucosal immunity via secreted immunoglobulin A . Use of th... |
9e77b6e78b58_0 | 9e77b6e78b58 | 81 | Title: Virus-Vectored Influenza Virus Vaccines
Passage: February and then manufacturers begin production, taking at least six months to produce the millions of vaccine doses required for the fall . If the prediction is imperfect, or if manufacturers have issues with vaccine production, vaccine efficacy or availability ... |
41a6a933b5e8_0 | 41a6a933b5e8 | 82 | Title: Efficacy and synergy of live-attenuated and inactivated influenza vaccines in young chickens
Passage: decade and it has been reported to protect young individuals better than IIV . Importantly, recent studies showed that LAIV can pre-sensitize the population and, subsequently, synergistically boost the efficacy ... |
8192959bda15_0 | 8192959bda15 | 83 | Title: Virus-Vectored Influenza Virus Vaccines
Passage: in humans . Currently, NA-specific antibody responses are not considered a correlate of protection . LAIV is administered as a nasal spray and contains the same three or four influenza virus strains as inactivated vaccines but on an attenuated vaccine backbone . L... |
0205563df4ff_0 | 0205563df4ff | 84 | Title: Estimating the number of infections and the impact of non-
Passage: representing between 1.88% and 11.43% ofthe population. The proportion of the population infected |
84c6ecbeabfb_0 | 84c6ecbeabfb | 85 | Title: Estimating the number of infections and the impact of non-
Passage: 03/0 25% 50% 753% 100% |
54cbbffdf075_0 | 54cbbffdf075 | 86 | Title: Estimating the number of infections and the impact of non-
Passage: Country % of total population infected |
24c6de07b832_0 | 24c6de07b832 | 87 | Title: Quantifying social distancing arising from pandemic influenza
Passage: The total population size of Sydney was NZ810 700, of which at least 14 130 were admitted to hospital and approximately 3500 died as a result of influenza infection . Based on a survey of 600 establishments covering 106 923 employees, the pro... |
fa94f3bd4e8d_0 | fa94f3bd4e8d | 88 | Title: Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes
Passage: Like SARS-CoV, 2019-nCoV induced pneumonia through respiratory tract by clinical observation. Therefore, the presence of viral antigen in oral swabs was used as detection standard for 2019-nCo... |
8c89a396ae94_0 | 8c89a396ae94 | 89 | Title: Pandemic (H1N1) 2009 Risk for Frontline Health Care Workers
Passage: swabs were only taken when patients were symptomatic. Previously, virus isolation has been the gold standard for infl uenza detection but RT-PCR is now considered to be more sensitive and specifi c. A previous study by some of the current autho... |
c62e28975289_0 | c62e28975289 | 90 | Title: Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes
Passage: In the first investigation, we aimed to test whether viral positive can be found in anal swab and blood as well as oral swabs. We conducted a molecular investigation to patients in Wuhan pulmo... |
549c7a101095_0 | 549c7a101095 | 91 | Title: Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes
Passage: through routine surveillance, and thus pose a threat to other people. In contrast, we found viral antibodies in near all patients, indicating serology should be considered for 2019-nCoV epidem... |
aacfa59fad67_0 | aacfa59fad67 | 92 | Title: Advanced Molecular Surveillance of Hepatitis C Virus
Passage: Hepatitis C virus infection is an important global public health problem. Approximately 180 million people are currently infected with HCV , and an alarming number of new infections occur annually . The prevalence of hepatitis C varies significantly w... |
90a3d49247d2_0 | 90a3d49247d2 | 93 | Title: Development and Applications of VSV Vectors Based on Cell Tropism
Passage: Hepatitis C virus has already infected more than 3% of the worldwide population and 80% of those infected develop persistent HCV infection . Persistent HCV infection often leads to chronic hepatitis, hepatic steatosis, cirrhosis, and hepa... |
1781c90dcb72_0 | 1781c90dcb72 | 94 | Title: Interferon Lambda: Opportunities, Risks, and Uncertainties in the Fight Against HCV
Passage: Hepatitis C virus is a positive sense, single-stranded RNA virus in the family Flaviviridae. It is estimated that as many as 160 million people are chronically infected worldwide with 3-4 million new infections every yea... |
f02d4fd60ba0_0 | f02d4fd60ba0 | 95 | Title: The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy
Passage: Worldwide 92-149 million people, representing approximately 2% of the world's population, are chronically infected with HCV , one of the causative agents of viral hepatitis. HCV is a blood borne virus and transmission occurs par... |
64251db7f306_0 | 64251db7f306 | 96 | Title: Self-Interest versus Group-Interest in Antiviral Control
Passage: summarize the main findings. |
c5be49a24ce2_0 | c5be49a24ce2 | 97 | Title: Estimating the number of infections and the impact of non-
Passage: main analysis. |
2394d5efc351_0 | 2394d5efc351 | 98 | Title: Preliminary Findings of a Randomized Trial of Non-Pharmaceutical Interventions to Prevent Influenza Transmission in Households
Passage: Characteristics of the 198 subjects are shown in Table 1 according to intervention arm. In general the groups were wellmatched. After randomization 70 of the households declined... |
f1c181f39229_0 | f1c181f39229 | 99 | Title: Preliminary Findings of a Randomized Trial of Non-Pharmaceutical Interventions to Prevent Influenza Transmission in Households
Passage: In terms of adherence, 45% of index subjects in the face mask arm reported wearing a mask often or always during the follow-up period, compared to 30% and 28% in the control and... |
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