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NCT00000102 | Congenital Adrenal Hyperplasia: Calcium Channels as Therapeutic Targets | This study will test the ability of extended release nifedipine (Procardia XL), a blood
pressure medication, to permit a decrease in the dose of glucocorticoid medication children
take to treat congenital adrenal hyperplasia (CAH). | :
- diagnosed with Congenital Adrenal Hyperplasia (CAH)
- normal ECG during baseline evaluation | :
- history of liver disease, or elevated liver function tests
- history of cardiovascular disease | 1/2 | https://clinicaltrials.gov/show/NCT00000102 | 14 Years | 35 Years | All |
NCT00000105 | Vaccination With Tetanus and KLH to Assess Immune Responses. | The purpose of this study is to learn how the immune system works in response to vaccines. We
will give the vaccines to subjects who have cancer but have not had treatment, and to
patients who have had chemotherapy or stem cell transplant. Some patients will get vaccines
while they are on treatment... | :
- Patients must have a diagnosis of cancer of any histologic type.
- Patients must have a Karnofsky performance status great or equal to 70%.
- Patients must have an expected survival for at least four months.
- Normal healthy volunteers to serve as control for ... | :
- Pregnant or lactating women. Females of child-bearing potential will be asked to take
a pregnancy test before receiving vaccines.
- Serious intercurrent medical illnesses which would interfere with the ability of the
patient to carry out the follow-up monitori... | na | https://clinicaltrials.gov/show/NCT00000105 | 18 Years | N/A | All |
NCT00000106 | 41.8 Degree Centigrade Whole Body Hyperthermia for the Treatment of Rheumatoid Diseases | Recently a non-toxic system for whole body hyperthermia (WBH) used at the University of
Wisconsin has been shown to induce soluble tumor necrosis factor-receptor (sTNF-R) I and II
when patients are heated systemically to 41.8C for 60 minutes. This observation might provide
a biological basis for th... | :
- Patients are required to meet the criteria of the American College of Rheumatology
(ACR)for rheumatoid arthritis.
- Patients should be in functional class II, or III according to the criteria of the
ACR.
- All candidates must be unsuccessfully tr... | null | n/a | https://clinicaltrials.gov/show/NCT00000106 | 18 Years | 65 Years | All |
NCT00000108 | Effects of Training Intensity on the CHD Risk Factors in Postmenopausal Women | The purpose of this research is to find out whether training at different exercise
intensities reduces the risk of developing cardiovascular disease (CVD) to a different
extent. Heart attacks and stroke are the leading cause of death in older women. Reduced
variability of the heart rate and increas... | :
- Postmenopausal and preferably on hormone replacement therapy
- In good general health
- Have a body mass index (BMI, weight in kg/height in m2) of between 25 and 40
- Exercise less than 20 min/day two days a week | null | n/a | https://clinicaltrials.gov/show/NCT00000108 | 50 Years | 65 Years | Female |
NCT00000110 | Influence of Diet and Endurance Running on Intramuscular Lipids Measured at 4.1 TESLA | The purpose of this pilot investigation is to use 1 H Magnetic Resonance Spectroscopy (MRS)
to 1) document the change in intra-muscular lipid stores (IML) before and after a prolonged
bout of endurance running and, 2) determine the pattern (time course) of IML replenishment
following an extremely l... | :
- Healthy volunteers (developmental phase)
- Healthy endurance-trained subjects
- Maximum age for males is 39
- Maximum age for females is 49 | null | n/a | https://clinicaltrials.gov/show/NCT00000110 | 18 Years | 49 Years | All |
NCT00000113 | Correction of Myopia Evaluation Trial (COMET) | To evaluate whether progressive addition lenses (PALs) slow the rate of progression of
juvenile-onset myopia (nearsightedness) when compared with single vision lenses, as measured
by cycloplegic autorefraction. An additional outcome measure is axial length, as measured by
A-scan ultrasonography.
... | Children between the ages of 6 and 12 years with myopia in both eyes (defined as spherical
equivalent between -1.25 D and -4.50 D in each eye as measured by cycloplegic
autorefraction), astigmatism less than or equal to 1.50 D, and no anisometropia (defined as
a difference in spherical equiva... | include visual acuity greater than 20/25, strabismus, use
of contact lenses, birth weight less than 1,250 grams, use of bifocal or progressive
addition lenses, or any conditions precluding adherence to the protocol. | 3 | https://clinicaltrials.gov/show/NCT00000113 | 6 Years | 12 Years | All |
NCT00000114 | Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa | To determine whether supplements of vitamin A or vitamin E alone or in combination affect the
course of retinitis pigmentosa. | Men and nonpregnant women between ages 18 and 49 years with common forms of RP were
included. All eligible patients had retinal arteriolar attenuation, elevated dark
adaptation thresholds, and reduced ERGs. Patients had best corrected Snellen visual acuity
of 20/100 or better, central visual ... | null | 3 | https://clinicaltrials.gov/show/NCT00000114 | 18 Years | 49 Years | All |
NCT00000115 | Randomized Trial of Acetazolamide for Uveitis-Associated Cystoid Macular Edema | To test the efficacy of acetazolamide for the treatment of uveitis-associated cystoid macular
edema. | Males and females 8 years of age or older and weighing at least 35 kg (77 lb) were eligible
for the study. Patients had to have a best corrected visual acuity of 20/40 or worse in at
least one eye with cystoid macular edema demonstrable on fluorescein angiography.
Patients were allowed to r... | included current use of acetazolamide as part of a therapeutic regimen; a history of
hypersensitivity reactions to acetazolamide, sulfonamides, or angiography dye; unclear
ocular media that would obscure fluorescein angiography; macular subretinal
neovascularization or a macular hole; or inab... | 2 | https://clinicaltrials.gov/show/NCT00000115 | 8 Years | N/A | All |
NCT00000117 | Intravenous Immunoglobulin Therapy in Optic Neuritis | To determine whether high-dose intravenous immunoglobulin (IVIg) is more effective than
placebo in restoring lost visual function (visual acuity) in optic neuritis (ON).
To determine the time course of recovery following IVIg administration. If the reports of
IVIg-associated clinical improvement ... | To be eligible, patients must have a history of one or more episodes of previous
demyelinating optic neuritis occurring in the setting of classic, adult-onset definite MS
(clinically definite or laboratory-supported definite MS, or cranial MRI changes consistent
with MS). In most cases, onset... | null | 3 | https://clinicaltrials.gov/show/NCT00000117 | N/A | 50 Years | All |
NCT00000118 | Ganciclovir Implant Study for Cytomegalovirus Retinitis | To determine the therapeutic efficacy of a sustained-release intraocular drug delivery system
for ganciclovir therapy of cytomegalovirus (CMV) retinitis in patients with acquired
immunodeficiency syndrome (AIDS). | All patients must have had AIDS as defined by the Centers for Disease Control and
Prevention and non-sight-threatening CMV retinitis Patients could not have been previously
treated with systemic ganciclovir or foscarnet and must not have had evidence of other
organ involvement with CMV. Patie... | null | 3 | https://clinicaltrials.gov/show/NCT00000118 | N/A | N/A | All |
NCT00000119 | Safety and Efficacy of a Heparin-Coated Intraocular Lens in Uveitis | To investigate the safety and efficacy of a heparin surface-modified intraocular lens in
patients with uveitis undergoing cataract surgery.
To evaluate the safety and efficacy of intraocular lens implantation in patients with severe
uveitis. | Women and men 18 years or older with a documented history of uveitis in an eye requiring
cataract surgery are eligible for the study. In all patients, the eye must be free of
active inflammation for at least 3 months before surgery, with or without anti-inflammatory
medications. | include corneal pathology or hazy media that preclude
evaluation of the intraocular lens, uncontrolled glaucoma, and diabetes mellitus. Monocular
patients and patients who cannot be followed for at least 1 year are also excluded. | 2 | https://clinicaltrials.gov/show/NCT00000119 | 18 Years | N/A | All |
NCT00000120 | Clinical Trial of Eye Prophylaxis in the Newborn | To compare the effectiveness of silver nitrate drops, erythromycin ointment, or no medication
in preventing neonatal conjunctivitis caused by Chlamydia trachomatis and other eye
infections.
To compare side effects of the two prophylactic agents. | The study included male and female infants delivered at University Hospital in Seattle,
Washington. Women were recruited after the 28th week of pregnancy and had to be
English-speaking. In addition, they planned to stay at the hospital at least 48 hours
following delivery and lived in the gre... | null | 3 | https://clinicaltrials.gov/show/NCT00000120 | N/A | 1 Year | All |
NCT00000121 | The Prism Adaptation Study (PAS) | To determine whether the preoperative use of prisms in eyeglasses can improve the outcome of
surgery for acquired esotropia, a type of strabismus.
To determine whether patients who respond to prism adaptation by developing a new stable
angle of -deviation have a better surgical result than do pat... | An eligible male or female must have been age 3 years or older (adults were included) and
must have had esotropia that occurred at age 6 months or older, with no history of previous
eye muscle surgery. | null | 3 | https://clinicaltrials.gov/show/NCT00000121 | 3 Years | N/A | All |
NCT00000122 | Fluorouracil Filtering Surgery Study (FFSS) | To determine whether postoperative subconjunctival injections of 5-fluorouracil (5-FU)
increase the success rate of filtering surgery in patients at high risk for failure after
standard glaucoma filtering surgery. | Men and women with uncontrolled intraocular pressure greater than 21 mm Hg in one or both
eyes despite maximal tolerated therapy and who were aphakic or had undergone previous
filtering surgery were eligible to participate. | null | 3 | https://clinicaltrials.gov/show/NCT00000122 | N/A | N/A | All |
NCT00000123 | The Berkeley Orthokeratology Study | To evaluate the relative efficacy of orthokeratology, primarily by assessment of changes in
central corneal thickness, astigmatism, visual acuity, endothelial cell density, and corneal
curvature.
To evaluate the relative safety of orthokeratology, primarily by assessment of changes in
cent... | Myopic volunteers, ages 20 to 35, who had not worn contact lenses were eligible to
participate in the study if they were free of ocular disease, were in good physical health,
and were not taking systemic medications that could have ocular side effects. In addition,
eligibility was limited to ... | null | 3 | https://clinicaltrials.gov/show/NCT00000123 | 20 Years | 35 Years | All |
NCT00000124 | Collaborative Ocular Melanoma Study (COMS) | To evaluate therapeutic interventions for patients who have choroidal melanoma, the most
common primary eye cancer affecting adults, and to assess the potential life-preserving as
well as sight-preserving role of radiation therapy.
To determine which of two standard treatments, removal of the eye... | Men and women eligible for the study must be age 21 or older, have primary choroidal
melanoma in only one eye, and have no evidence of metastatic disease. Accurate estimation
of tumor thickness by echography must also be possible. | null | 3 | https://clinicaltrials.gov/show/NCT00000124 | 21 Years | N/A | All |
NCT00000125 | Ocular Hypertension Treatment Study (OHTS) | To determine whether medical reduction of intraocular pressure prevents or delays the onset
of glaucomatous visual field loss and/or optic disc damage in ocular hypertensive
participants judged to be at moderate risk for developing open-angle glaucoma.
To produce natural history data to assist in... | Men and nonpregnant women between the ages of 40 and 80 with IOP greater than or equal to
24 mm Hg but less than or equal to 32 mm Hg in at least one eye and IOP greater than or
equal to 21 but less than or equal to 32 mm Hg in the fellow eye, as well as normal visual
fields and optic discs a... | null | 3 | https://clinicaltrials.gov/show/NCT00000125 | 40 Years | 80 Years | All |
NCT00000126 | Ischemic Optic Neuropathy Decompression Trial Followup (IONDT Followup) | To follow all patients enrolled in the original Ischemic Optic Neuropathy Decompression Trial
(IONDT) to determine (1) the incidence of non-arteritic ischemic optic neuropathy (NAION) in
the second eye, (2) changes in visual acuity over time in both the study and second eye, and
(3) other aspects o... | All living patients from the 420 patients originally enrolled in the IONDT have been asked
to participate in the IONDT Followup Study. No new patients are being recruited. | null | na | https://clinicaltrials.gov/show/NCT00000126 | 50 Years | N/A | All |
NCT00000127 | Ischemic Optic Neuropathy Decompression Trial (IONDT) | To assess the safety and efficacy of optic nerve sheath decompression surgery for
non-arteritic ischemic optic neuropathy (NAION). | Men and women age 50 years or older, with acute NAION and visual symptoms for 14 days or
less since the onset of symptoms, and visual acuity worse than or equal to 20/64 were
eligible for randomization. | null | 3 | https://clinicaltrials.gov/show/NCT00000127 | 50 Years | N/A | All |
NCT00000129 | Prospective Evaluation of Radial Keratotomy (PERK) Study | To determine whether radial keratotomy is effective in reducing myopia.
To detect complications of the surgery.
To discover patient characteristics and surgical factors affecting the results.
To determine the long-term safety and efficacy of the procedure. | All men and women had 2 to 8 diopters of simple myopia and were correctable to 20/20 or
better with glasses or contact lenses. All patients had the stability of their myopia
documented by previous records. Patients were at least 21 years of age and lived in the
metropolitan area of the study ... | null | 3 | https://clinicaltrials.gov/show/NCT00000129 | 21 Years | N/A | All |
NCT00000131 | Central Vein Occlusion Study (CVOS) | To determine whether photocoagulation therapy can help prevent iris neovascularization in
eyes with central vein occlusion (CVO) and evidence of ischemic retina.
To assess whether grid-pattern photocoagulation therapy will reduce loss of central visual
acuity due to macular edema secondary to CVO... | Men and women must have been age 21 or older and willing to return for followup visits for
3 years following assignment into the appropriate group and randomization. Each of the four
groups has specific eligibility criteria. Patients with retinal vascular disease other than
that specified in ... | null | 3 | https://clinicaltrials.gov/show/NCT00000131 | 21 Years | N/A | All |
NCT00000132 | Early Manifest Glaucoma Trial (EMGT) | The primary purpose is to compare the effect of immediate therapy to lower the intraocular
pressure (IOP) versus late or no treatment on the progression of newly detected open-angle
glaucoma, as measured by increasing visual field loss and/or optic disc changes.
The secondary purposes are to dete... | Men and women between ages 50 and 80 years who have newly detected and untreated chronic
open-angle glaucoma with repeatable visual field defects by Humphrey perimetry are eligible
for inclusion. | include the following: advanced visual field loss (MD less than or equal
to 16 dB) or threat to fixation; mean IOP > 30 mm Hg or any IOP > 35 mm Hg in at least one
eye; VA < 0.5 in either eye; or any conditions precluding reliable fields or photos, use of
study treatment, or 4-year followup. | 3 | https://clinicaltrials.gov/show/NCT00000132 | 50 Years | 80 Years | All |
NCT00000133 | Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) - Outcome Study of Cryotherapy for Retinopathy of Prematurity | To determine the safety and efficacy of trans-scleral cryotherapy of the peripheral retina in
certain low birth-weight infants with retinopathy of prematurity (ROP) for reducing blindness
from ROP.
To determine the long-term outcome for eyes that had severe ("threshold") ROP, both with and
... | Premature infants of either gender who were eligible for the natural history study had
weighed less than 1,251 grams at birth and had survived the first 28 days of life. They had
no major ocular or systemic congenital anomalies. Infants who met these criteria and also
had a threshold level of... | null | n/a | https://clinicaltrials.gov/show/NCT00000133 | N/A | 1 Year | All |
NCT00000135 | Studies of the Ocular Complications of AIDS (SOCA)--Monoclonal Antibody CMV Retinitis Trial (MACRT) | To evaluate the efficacy and safety of a human anti-CMV monoclonal antibody, MSL-109, as
adjunct therapy for controlling CMV retinitis. | :
- 13 years or older at entry
- Diagnosis of AIDS according to the Centers for Disease Control and Prevention (CDC)
definition
- Diagnosis of active CMV retinitis as determined by a SOCA-certified ophthalmologist at
time of enrollment
-... | :
- Current treatment with intravenous immune globulin (IVIG), CMV immune globulin
(CMVIG), alpha-interferon (alpha-IFN), gamma-interferon (gamma-IFN) or interleukin-2
(IL-2)
- Media opacity that precludes visualization of the fundus in all eyes meeting
... | 2/3 | https://clinicaltrials.gov/show/NCT00000135 | 13 Years | N/A | All |
NCT00000136 | Studies of the Ocular Complications of AIDS (SOCA)--Foscarnet-Ganciclovir CMV Retinitis Trial (FGCRT) | To evaluate the relative safety and efficacy of ganciclovir and foscarnet as initial
treatment of patients with cytomegalovirus (CMV) retinitis. | :
- CMV retinitis in one or both eyes
- At least 1/4 disk are of one CMV lesion photographable
- Diagnosis of AIDS as defined by Center for Disease Control criteria or documented HIV
infection
- Age 13 and greater
- Visual acuity ≥ 3/20... | :
- Previous treatment of CMV retinitis
- Treatment with anti-CMV therapy for an extra-ocular CMV infection currently or in the
past 28 days
- Known or suspected allergy to study drugs
- Pregnant or Lactating | 3 | https://clinicaltrials.gov/show/NCT00000136 | 13 Years | N/A | All |
NCT00000137 | Collaborative Corneal Transplantation Studies (CCTS) | To determine whether histocompatibility matching of corneal transplant donors and recipients
can reduce the incidence of graft rejection in high-risk patients. | Males and females age 10 years or older with two to four quadrants of corneal stroma
vascularization or a history of allograft rejection in the eye considered for surgery were
eligible for both studies in the CCTS.
Patients must have been willing to participate in 3 years of followup. No on... | null | 3 | https://clinicaltrials.gov/show/NCT00000137 | 10 Years | N/A | All |
NCT00000138 | Herpetic Eye Disease Study (HEDS) I | To evaluate the efficacy of topical corticosteroids in treating herpes simplex stromal
keratitis in conjunction with topical trifluridine.
To evaluate the efficacy of oral acyclovir in treating herpes simplex stromal keratitis in
patients receiving concomitant topical corticosteroids and trifluri... | Eligibility criteria common to the three protocols included age 12 years or older, no
active HSV epithelial keratitis, no prior keratoplasty of the involved eye, and not
pregnant. Protocol-specific criteria are noted in the description above. | null | 3 | https://clinicaltrials.gov/show/NCT00000138 | 12 Years | N/A | All |
NCT00000140 | The Silicone Study | To compare, through a randomized, multicenter surgical trial, the postoperative tamponade
effectiveness of intraocular silicone oil with that of an intraocular long-acting gas
(initially sulfur hexafluoride [SF 6 ], later perfluoropropane [C 3 F 8 ]) for the management
of retinal detachment complic... | Eligibility criteria included but were not limited to PVR of Grade C-3 or greater according
to the Retina Society Classification and visual acuity of light perception or better. | null | 3 | https://clinicaltrials.gov/show/NCT00000140 | N/A | N/A | All |
NCT00000142 | Studies of the Ocular Complications of AIDS (SOCA)--HPMPC Peripheral CMV Retinitis Trial (HPCRT) | To test and evaluate the efficacy and safety of intravenous cidofovir (Vistide, previously
known as HPMPC) for the treatment of retinitis. | :
- diagnosis of AIDS according to the Centers for Disease Control and Prevention (CDC)
- 13 years or older
- Diagnosis of CMV (cytomegalovirus) retinitis as determined by a SOCA-certified
Ophthalmologist.
- At least one lesion whose size is one-quar... | :
- Evidence of a CMV (cytomegalovirus) retinitis lesion within zone 1. A lesion less than
1,500 µ from the margin of the optic disc or less than 3,000 µ from the center of the
fovea in either eye excludes a patient.
- Evidence of a CMV retinitis lesions that invo... | 2/3 | https://clinicaltrials.gov/show/NCT00000142 | 13 Years | N/A | All |
NCT00000144 | Glaucoma Laser Trial (GLT) Glaucoma Laser Trial Followup Study (GLTFS) | To compare the safety and long-term efficacy of argon laser treatment of the trabecular
meshwork with standard medical treatment for primary open-angle glaucoma. | At the time of recruitment, patients had to be at least 35 years old with an intraocular
pressure of at least 22 mm Hg or greater in each eye and evidence of optic nerve damage in
at least one eye. | null | 3 | https://clinicaltrials.gov/show/NCT00000144 | 35 Years | N/A | All |
NCT00000149 | Collaborative Initial Glaucoma Treatment Study (CIGTS) | To compare the long-term effect of treating newly diagnosed open-angle glaucoma with standard
medical treatment versus filtration surgery. | Patients must be at least 25 years old with an intraocular pressure of 20 mm Hg or greater
and evidence of optic nerve damage and/or visual field loss in one or both eyes. The ocular
findings must exclude causes of glaucoma other than primary open-angle glaucoma, pigmentary
glaucoma, or pseud... | null | 3 | https://clinicaltrials.gov/show/NCT00000149 | 25 Years | 75 Years | All |
NCT00000150 | Submacular Surgery Trials (SST) | To determine whether surgical removal of subfoveal choroidal neovascularization (CNV) and
associated hemorrhage in patients with age-related macular degeneration (AMD), the ocular
histoplasmosis syndrome (OHS), or idiopathic CNV stabilizes or improves vision more often
than observation.
To... | Group B: Patients with evidence of large hemorrhages from subfoveal neovascular AMD
lesions, visual acuity (SST protocol) of 20/100 to light perception, with the area of
hemorrhage larger than the area of fluorescein angiographically visible CNV, with any
visible CNV less than or equal to 9 M... | include other ocular diseases compromising vision, history of submacular
surgery in the study eye, history of subfoveal laser photocoagulation that extends under
the foveal avascular zone, recent intraocular surgery, or previous investigational therapy
for CNV. | 3 | https://clinicaltrials.gov/show/NCT00000150 | 18 Years | N/A | All |
NCT00000151 | Early Treatment Diabetic Retinopathy Study (ETDRS) | To evaluate the effectiveness of both argon laser photocoagulation and aspirin therapy in
delaying or preventing progression of early diabetic retinopathy to more severe stages of
visual loss and blindness.
To help determine the best time to initiate photocoagulation treatment in diabetic
... | Men and women between the ages of 18 and 70 years with moderate or severe nonproliferative
diabetic retinopathy or mild proliferative retinopathy in both eyes, with no previous
photocoagulation treatment, and with visual acuity of 20/40 or better (20/200 or better if
macular edema is present)... | null | 3 | https://clinicaltrials.gov/show/NCT00000151 | 18 Years | 70 Years | All |
NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | To determine whether 50 mg of beta-carotene taken every other day reduces the risk of
developing age-related macular degeneration (AMD) among male U.S. physicians who were aged 40
to 84 in 1982.
To investigate the possible relationship of AMD with other antioxidants, including selenium
and... | When the Physicians Health Study was established in the early 1980s by the NHLBI to collect
data on a stable population at risk for heart attack, only male physicians were studied
because males were thought to be at higher risk than females for ischemic heart problems.
The study population co... | null | 3 | https://clinicaltrials.gov/show/NCT00000152 | 40 Years | 84 Years | Male |
NCT00000153 | Krypton-Argon Regression of Neovascularization Study (KARNS) | To evaluate whether red krypton laser treatment is as effective at causing regression of
diabetic disc neovascularization as treatment with the blue-green argon laser, when both
lasers are used with identical panretinal photocoagulation patterns.
To assess the vision of study patients.
T... | Men and women ages 18 through 79 diagnosed with diabetes mellitus and who had
neovascularization on the optic nerve head (NVD) were eligible. NVD in one or both eyes of
each patient had to be greater than or equal to DRS Standard Photograph 10A. NVD was
defined as new vessels on the surface o... | null | 3 | https://clinicaltrials.gov/show/NCT00000153 | 18 Years | 79 Years | All |
NCT00000154 | Diabetic Retinopathy Vitrectomy Study (DRVS) | To compare two therapies, early vitrectomy and conventional management, for recent severe
vitreous hemorrhage secondary to diabetic retinopathy. Conventional management includes
vitrectomy if hemorrhage fails to clear during a waiting period of 6 to 12 months or if
retinal detachment involving the ... | Men and women eligible for the vitreous hemorrhage group had at least one eye with recent
severe vitreous hemorrhage (within 5 months) and visual acuity of 5/200 or less. Patients
eligible for the "very severe proliferative retinopathy with useful vision" group had
extensive active fibrovascu... | null | 3 | https://clinicaltrials.gov/show/NCT00000154 | 18 Years | 70 Years | All |
NCT00000155 | The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study | To describe the clinical course of keratoconus and to describe the relationships among its
visual and physiological manifestations, including high- and low-contrast visual acuity,
corneal curvature, slit lamp biomicroscopic findings, corneal scarring, and quality of life.
To identify risk factors... | Patients with keratoconus were eligible if they were at least 12 years old; had an
irregular cornea as determined by keratometry, retinoscopy, or direct ophthalmoscopy in at
least one eye; had Vogt's striae, Fleischer's ring, or corneal scarring characteristic of
keratoconus in at least one e... | null | na | https://clinicaltrials.gov/show/NCT00000155 | 12 Years | N/A | All |
NCT00000156 | The Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP) | To evaluate the effect of ambient light reduction on the incidence of retinopathy of
prematurity (ROP). | Premature infants weighing less than 1,251 grams at birth and having a gestational age of
less than 31 weeks were eligible for randomization. Consent must have been obtained within
24 hours of birth. Patients with major congenital anomalies are excluded. | null | 3 | https://clinicaltrials.gov/show/NCT00000156 | N/A | 1 Day | All |
NCT00000158 | Macular Photocoagulation Study (MPS) | To evaluate laser treatment of choroidal neovascularization (CNV) through randomized,
controlled clinical trials. The Macular Photocoagulation Study (MPS) consisted of three sets
of randomized, controlled clinical trials. Change in best-corrected visual acuity from
baseline was the primary outcome ... | Common Eligibility Criteria for the Argon, Krypton, and Foveal Studies:
To be eligible, men and women must have been experiencing visual symptoms attributable to
the macular lesion, such as decreased visual acuity or Amsler grid distortion, at the time
of entry into the study. They also mus... | null | 3 | https://clinicaltrials.gov/show/NCT00000158 | 18 Years | N/A | All |
NCT00000159 | Sorbinil Retinopathy Trial (SRT) | To evaluate the safety and efficacy of the investigational drug sorbinil, an aldose reductase
inhibitor, in preventing the development of diabetic retinopathy and neuropathy in persons
with insulin-dependent diabetes. | Men and women eligible for the SRT had diabetes for 1 to 15 years and were between ages 18
and 56 at the time of enrollment. They had begun taking insulin before their 41st birthday.
Their hemoglobin A1c value was within the diabetic range. On retinal examination, they
showed no evidence of o... | null | 3 | https://clinicaltrials.gov/show/NCT00000159 | 18 Years | 56 Years | All |
NCT00000160 | Diabetic Retinopathy Study (DRS) | To determine whether photocoagulation helps prevent severe visual loss from proliferative
diabetic retinopathy.
To determine whether a difference exists in the efficacy and safety of argon versus xenon
photocoagulation for proliferative diabetic retinopathy. | Patients were eligible if they had best corrected visual acuity of 20/100 or better in each
eye and the presence of proliferative diabetic retinopathy in at least one eye or severe
nonproliferative retinopathy in both eyes. They could not have had prior treatment with
photocoagulation or pitu... | null | 3 | https://clinicaltrials.gov/show/NCT00000160 | N/A | 70 Years | All |
NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | To determine whether vitamin E supplementation reduces the risk of cataract and age-related
macular degeneration (AMD) in women.
To determine whether vitamin C supplementation reduces the risk of cataract and AMD in women.
To determine whether beta-carotene supplementation reduces the risk of c... | Women's Health Study:
A participant must have met all of the following criteria:
(a) female; (b) aged 45 years or older; (c) postmenopausal or with no intention of becoming
pregnant; (d) no reported personal history of cardiovascular disease, cancer (other than
non-melanoma skin ... | null | 3 | https://clinicaltrials.gov/show/NCT00000161 | 45 Years | N/A | Female |
NCT00000167 | Complications of Age-Related Macular Degeneration Prevention Trial | To determine whether application of low-intensity laser treatment of eyes with drusen in the
macula can prevent later complications of age-related macular degeneration and thereby
preserve visual function. | Patients eligible for CAPT can be either male or female and meet the following criteria:
Age at least 50 years old
Vision in each eye must measure 20/40 or better.
At least 10 large drusen in each eye
Available for follow-up examinations for 5 years after enrollment
... | null | 3 | https://clinicaltrials.gov/show/NCT00000167 | 50 Years | N/A | All |
NCT00000171 | Study of Melatonin: Sleep Problems in Alzheimer's Disease | This protocol is a multicenter clinical trial of melatonin for sleep disturbances associated
with Alzheimer's disease (AD). Frequent nocturnal awakening is a common behavioral symptom of
AD. Nighttime wandering and agitated behavior may result in injuries and sleep disruption for
caregivers. Altern... | :
- Patients must meet NINCDS-ADRDA criteria for probable Alzheimer's disease (AD).
Patients must have disrupted sleep, documented by clinical history and by 1 to 2 weeks
of recording using wrist activity monitors.
- A diagnosis of probable AD.
- MMS... | :
- Sleep disturbance is acute (within the last 2 weeks).
- Sleep disturbance is associated with an acute illness with delirium.
- Clinically significant movement disorder that would interfere with the actigraph
readings.
- Not having a mobile upper ... | 3 | https://clinicaltrials.gov/show/NCT00000171 | 55 Years | N/A | All |
NCT00000173 | Memory Impairment Study (Mild Cognitive Impairment Study) | The National Institute on Aging (NIA) is launching a nationwide treatment study targeting
individuals with mild cognitive impairment (MCI), a condition characterized by a memory
deficit, but not dementia. An NIA-funded study recently confirmed that MCI is different from
both dementia and normal age... | :
- Memory complaints and memory difficulties which are verified by an informant.
- Abnormal memory function documented by scoring below the education adjusted cutoff on
the Logical Memory II subscale (Delayed Paragraph Recall) from the Wechsler Memory
Scale - Rev... | :
- Any significant neurologic disease other than suspected incipient Alzheimer's disease,
such as Parkinson's disease, multi-infarct dementia, Huntington's disease, normal
pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder,
subd... | 3 | https://clinicaltrials.gov/show/NCT00000173 | 55 Years | 90 Years | All |
NCT00000176 | Alzheimer's Disease Prevention Trial | This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's
disease in women with a family history of Alzheimer's disease. | :
- Healthy women 65 or older with a family history of memory problems not currently on
estrogen. | :
- Significant neurological impairment
- Current estrogen use
- History of breast cancer | 3 | https://clinicaltrials.gov/show/NCT00000176 | 65 Years | N/A | Female |
NCT00000179 | Agitation in Alzheimer's Disease | Agitation affects 70 to 90 percent of patients with AD. Signs of agitation include verbal and
physical aggressiveness, irritability, wandering, and restlessness. These behaviors often
make caring for patients at home very difficult. Trazodone and haldol are two of the most
commonly prescribed drugs... | :
- Memory problem consistent with a probable diagnosis of Alzheimer's disease (AD)
- Agitation symptoms for at least the past 2 weeks
- Patient has caregiver who can participate
- Patient lives in the same household as the caregiver | null | 3 | https://clinicaltrials.gov/show/NCT00000179 | 50 Years | N/A | All |
NCT00000292 | Acute Withdrawal From Smoked Cocaine - 9 | The purpose of this study is to develop an experimental paradigm to examine acute withdrawal
symptoms from cocaine. | :
M/F ages 21-45 with a history of smoked cocaine use at least twice a week for the past six
months, including 0.5 g of cocaine in a 24hr period on at least one occasion. In good
health as evidenced by physical exam and complete blood count, chest X-ray and electrolyte
and liver fu... | :
Any DSM-IV Axis I disorder other than cocaine abuse or dependence, or dependence or daily
use of psychoactive drugs other than nicotine or caffeine. A history of violence and/or
currently on probation, parole or awaiting trial. Pregnant as determined by serum pregnancy
screen, la... | 1 | https://clinicaltrials.gov/show/NCT00000292 | 21 Years | 45 Years | All |
NCT00000359 | Treatments for Benign Paroxysmal Positional Vertigo (BPPV) | The purpose of this study was to determine the relative short- and long-term efficacy of
several physical treatment paradigms commonly employed for the treatment of benign paroxysmal
positional vertigo (BPPV), including the canalith repositioning (Epley) maneuver, the
liberatory (Semont) maneuver, ... | :
Patients may be eligible for this study if they:
- Are at least 21 years old.
- Have a diagnosis of unilateral posterior semicircular canal BPPV according to
established clinical test criteria.
- Have functional to normal range of motion of the neck a... | :
Patients will not be eligible for this study if they:
- Have a history of prior ear surgery or prior treatment for BPPV.
- Have an orthopedic or connective tissue disorder that impairs functional neck or trunk
range of motion.
- Have a significant neu... | 2 | https://clinicaltrials.gov/show/NCT00000359 | 21 Years | N/A | All |
NCT00000361 | Autoimmunity in Inner Ear Disease | The purpose of this study is to determine whether prednisone, methotrexate, and
cyclophosphamide are effective in the treatment of rapidly progressive sensorineural hearing
loss in both ears. This condition is called autoimmune inner ear disease (AIED), because it
is thought that the hearing loss i... | :
- Have sensorineural (nerve/inner ear) hearing loss of at least 30 dB in each ear, which
has rapidly progressed.
- Are in good general health.
- Are sterile or use contraception (if a woman of child-bearing age).
- Are able to speak and understand ... | :
- Have had any previous reaction to prednisone, or history of psychiatric reaction to
corticosteroids.
- Have used corticosteroids for more than 30 days within the past 90 days. Patients who
have been off corticosteroids for at least 30 days may be eligible.
... | 3 | https://clinicaltrials.gov/show/NCT00000361 | 18 Years | 70 Years | All |
NCT00000362 | Randomized Study of Two Interventions for Liquid Aspiration: Short-Term and Long-Term Effects | The purpose of this study is to determine whether chin-down posture or use of a thickened
liquid diet is more effective in the prevention of aspiration and aspiration pneumonia in
patients with Parkinson's disease and/or dementia. Liquid aspiration is the most common type
of aspiration in older pop... | :
- Have dementia or Parkinson's disease and are found to aspirate on thin liquid during a
set of qualifying swallows. | :
- Have smoked more than a pack of cigarettes per day in the last year.
- Drink more than 3 alcoholic beverages per day on a regular basis.
- Have had any head and neck cancer treatment.
- Have any head and neck anatomic deformities.
- Have a histor... | 3 | https://clinicaltrials.gov/show/NCT00000362 | 50 Years | 95 Years | All |
NCT00000367 | Prevention of Suicide in the Elderly | The purpose of this study is to design a program to prevent suicide in elderly patients by
educating patients, their families, and physicians on depression and suicidal thoughts.
A program to prevent suicide in elderly patients needs to be developed. Since elderly
patients frequently have doctor'... | :
-
Patients must have:
Depressive symptoms and signs. (Required for 920 of the 1200 patients; 280 patients should
have no significant depressive symptomatology.) | null | n/a | https://clinicaltrials.gov/show/NCT00000367 | 60 Years | N/A | All |
NCT00000370 | Treatment of Social Phobia | Social phobia is a very common and debilitating disorder, with public speaking anxiety being
the most common fear. Psychologists have found that treating patients for their fear of
public speaking, through cognitive-behavioral treatment (talk-based therapy) or exposure
treatment (where participants... | :
-
Patients must have:
Social phobia with public speaking anxiety. | null | n/a | https://clinicaltrials.gov/show/NCT00000370 | N/A | N/A | All |
NCT00000377 | Preventing the Return of Depression in Elderly Patients | The purpose of this study is to compare the effectiveness of two doses of nortriptyline in
elderly patients whose depression returned after stopping treatment. Nortriptyline is an
antidepressant.
This study enrolls patients who were treated for depression in an earlier research study and
w... | :
-
Patients must have:
Recurrence of major depression while in a maintenance placebo condition in the currently
funded maintenance therapy protocol (Study I). | null | n/a | https://clinicaltrials.gov/show/NCT00000377 | 60 Years | 80 Years | All |
NCT00000388 | Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA) | This trial is a continuation of the Multimodal Treatment Study of Children with Attention
Deficit Hyperactivity Disorder (MTA Study). Continuation Aim 1 is to track the persistence of
intervention-related effects as the MTA sample matures into mid-adolescence, including
subsequent mental-health and... | :
-
Patients must have:
Rigorously diagnosed Attention Deficit Hyperactivity Disorder (ADHD). | null | 4 | https://clinicaltrials.gov/show/NCT00000388 | 7 Years | 9 Years | All |
NCT00000390 | Antidepressant Treatment of AIDS Related Depression. | To test the effectiveness treating AIDS related depression with imipramine hydrochloride.
Depression syndromes are commonly associated with chronic, disabling, and fatal diseases. Due
to the relentless course of HIV infection, there is a certain reluctance to treat the
associated depression. In o... | :
- Patient must be ambulatory and relatively good health. Even if unable to work at least
able to partially care care for self and not demented.
- May have been alcoholic or drug abuser 6 months previous.
- Unspecified
- CD4 Unspecified. | :
- Non ambulatory patients or those requiring extensive help in self care are excluded.
- Non ambulatory patients or those requiring extensive help in self care are excluded.
- Current alcohol or drug abuse.
- Unspecified | 2 | https://clinicaltrials.gov/show/NCT00000390 | 18 Years | 65 Years | All |
NCT00000395 | Antifolate Effectiveness in Arthritis | This study looks at how the arthritis drug methotrexate works in low doses to treat
rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.)
Methotrexate blocks the action of the B-vitamin known as folic acid. We are studying the
biochemical reactions affected by t... | :
- Individuals starting methotrexate for rheumatoid arthritis.
- Study subjects should not currently be taking folic acid-containing vitamins. | :
- Cancer, renal, or liver disease.
- Previous use of methotrexate within the past 6 months or current use of folic
acid-containing supplements. | 2 | https://clinicaltrials.gov/show/NCT00000395 | 18 Years | 85 Years | All |
NCT00000396 | Arthritis Patient Education for Urban African Americans | Research has shown that people with arthritis can improve their ability to cope with
arthritis pain with the help of patient education programs, which teach people things they
can do to help manage their disease. However, we do not know much about the effects of
arthritis patient education programs... | :
- Urban African Americans with arthritis
- 18 years or older | :
- None | n/a | https://clinicaltrials.gov/show/NCT00000396 | 18 Years | N/A | All |
NCT00000398 | Behavioral Treatment of Fibromyalgia | Fibromyalgia (FM) is one of the most common rheumatic diseases (conditions or disorders that
cause pain or stiffness in the joints, muscles, or bones). It affects 6 million Americans and
up to 20 percent of patients seen by doctors who specialize in treating rheumatic diseases.
This study will eval... | :
- Complaints of pain persisting for 6 months
- Meet diagnostic criteria for fibromyalgia (American College of Rheumatology criteria) | :
- A significant adverse medical condition that would expose the individual to increased
risk of an adverse experience during the course of the trial (e.g. a recent (<6
months) myocardial infarction)
- An abnormal cardiac response to exercise
- Othe... | 2 | https://clinicaltrials.gov/show/NCT00000398 | 21 Years | N/A | All |
NCT00000402 | Calcium and Bone Mass in Young Females | We originally suggested that calcium in the diet is important in determining the amount of
bone (bone mass) that builds up in young adults. We are testing the effect of calcium on bone
mass in 354 Caucasian (white) girls. At the start of this 7-year study, the average age of
the girls was 11 years,... | :
- Pubertal stage II
- Calcium intake below a threshold level
- Caucasian
- Normal health | :
- Medications affecting calcium and bone metabolism
- Chronic diseases
- Metabolic bone disease
- Abnormality in calcium metabolism | 2 | https://clinicaltrials.gov/show/NCT00000402 | 8 Years | 13 Years | Female |
NCT00000403 | Doxycycline and OA Progression | This study will determine whether doxycycline decreases the severity or rate of progression
of osteoarthritis (OA) in the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the
most popular agents used to treat OA, but elderly women, in whom OA is especially common, are
at greatest risk of dev... | :
- Women 45-64 years of age.
- Upper tertile of sex-, age- and race-adjusted norms for body mass index.
- Unilateral knee OA at baseline.
- Postmenopausal status or otherwise incapable of childbearing.
- Ability to ambulate (move about) independentl... | :
- Premenopausal status (unless subject has had a hysterectomy).
- Current use of any investigational drug.
- Significant hematologic, renal, hepatic or cardiovascular disease (but not including
mild/moderate hypertension) or any other serious medical condition t... | 3 | https://clinicaltrials.gov/show/NCT00000403 | 45 Years | 64 Years | Female |
NCT00000404 | Effects of Comprehensive Care for Knee OA | We will study 300 people with knee osteoarthritis (OA) who receive their medical care from a
large health maintenance organization (HMO) in Indianapolis. Our study will evaluate a
comprehensive plan for treatment of knee OA by primary care physicians. Primary care
physicians will provide standard c... | :
- Study participants must be treated for chronic knee pain by a primary care physician
at a participating HMO and satisfy American College of Rheumatology Clinical Criteria
for the diagnosis of knee OA.
- All subjects will be able to read and write English, have... | :
- Significant hematologic, renal, hepatic, or cardiovascular disease (but not including
mild/moderate hypertension) or any other serious medical condition that might preclude
the subject's ability to participate fully in the project, keep clinic appointments,
et... | 2 | https://clinicaltrials.gov/show/NCT00000404 | 40 Years | N/A | All |
NCT00000406 | Effects of Strength Training on Knee Osteoarthritis | To understand the effects of leg strengthening exercise, we will study the effects of
strength training of the legs in four groups of people: (1) osteoarthritis (OA) with knee
pain; (2) OA without knee pain; (3) no OA but elderly with knee pain; and (4) normal elderly
with no OA or knee pain. In ea... | :
- Males and females 60 to 100 years of age | :
- Knee joint replacement surgery
- Diabetes mellitus
- Uncontrollable hypertension
- Neuropathies of the lower extremity
- Poor mental cognition (i.e., inability to follow instructions) | 2 | https://clinicaltrials.gov/show/NCT00000406 | 60 Years | N/A | All |
NCT00000408 | Low Back Pain Patient Education Evaluation | Back pain is one of the most common of all symptoms. It is also a great cause of days lost
from work and visits to health care providers. This study will develop and evaluate an
approach to low back pain that allows subjects to talk with each other and with health
professionals via an Internet disc... | :
- Must live in the United States
- Must understand and write English
- Must have access to a computer with e-mail and expect to have this access for at least
3 years
- Must be 18 years old
- Must have seen a doctor for back pain at le... | :
- Pregnancy
- Back surgery in the past 6 months
- Expectation of having back surgery in the next 6 months
- Back pain due to a car accident or other major injury within the last 6 months
- Back pain or sciatica due to systemic disease (inflammatory... | n/a | https://clinicaltrials.gov/show/NCT00000408 | 18 Years | N/A | All |
NCT00000409 | Spine Patient Outcomes Research Trial (SPORT): Degenerative Spondylolisthesis With Spinal Stenosis | This study tests the effectiveness of different treatments for the three most commonly
diagnosed conditions of the lower backbone (lumbar spine). The purpose is to learn which of
two commonly prescribed treatments (surgery and nonsurgical therapy) works better for
specific types of low back pain.
... | :
- Duration of Symptoms: 12 or more weeks.
- Treatments Tried: Nonsteroidal. anti-inflammatory medical therapy and physical
therapy.
- Surgical Screening: Pain in low back, buttocks, or lower extremity that becomes worse
with lumbar extension. Must ... | :
- Previous lumbar spine surgery.
- Not a surgical candidate for any of these reasons: Overall health that makes spinal
surgery too life-threatening to be an appropriate alternative, patient has improved
dramatically with conservative care, or the patient is unab... | 4 | https://clinicaltrials.gov/show/NCT00000409 | 18 Years | N/A | All |
NCT00000410 | Spine Patient Outcomes Research Trial (SPORT) - Intervertebral Disc Herniation | This study tests the effectiveness of different treatments for the three most commonly
diagnosed lumbar (lower) spine conditions. The purpose of the study is to learn which of two
commonly prescribed treatments (surgery and non-surgical therapy) works better for specific
types of low back pain.
... | :
- Duration of symptoms: 6 or more weeks.
- Treatments tried: Non-steroidal anti-inflammatory medical therapy and physical
therapy.
- Surgical screening: Persistent radicular pain provoked by moderate exercise, sitting,
increased abdominal pressure,... | :
- Previous lumbar spine surgery.
- Not a surgical candidate for any of these reasons: Overall health which makes spinal
surgery too life-threatening to be an appropriate alternative, dramatic improvement
with conservative care, or inability (for any reason) to u... | 4 | https://clinicaltrials.gov/show/NCT00000410 | 18 Years | N/A | All |
NCT00000411 | Spine Patient Outcomes Research Trial (SPORT): Spinal Stenosis | This study tests the effectiveness of different treatments for the three most commonly
diagnosed conditions of the lower backbone (lumbar spine). The purpose is to learn which of
two commonly prescribed treatments (surgery and nonsurgical therapy) works better for
specific types of low back pain. L... | :
- Duration of Symptoms: 12 or more weeks.
- Treatments tried: Nonsteroidal anti-inflammatory medical therapy and physical therapy.
- Surgical Screening: Pain in low back, buttocks, or lower extremity that becomes worse
with lumbar extension. Must be confirmed by... | :
- Previous lumbar spine surgery.
- Not a surgical candidate for any of these reasons: Overall health that makes spinal
surgery too life-threatening to be an appropriate alternative, patient has improved
dramatically with conservative care, or the patient is unab... | 4 | https://clinicaltrials.gov/show/NCT00000411 | 18 Years | N/A | All |
NCT00000413 | Osteoporosis Prevention in Preadolescent Girls | This study will test an osteoporosis prevention program aimed at preadolescent girls between
the ages of 10 and 12 who have not yet started their menstrual periods. Girls in this age
group are adding large amounts of new bone to their skeletons. Adding more bone at this time
of life can reduce a pe... | :
- 9- and 10-year-old premenarchal girls (girls who have not started their periods). | :
- Comorbid conditions or medications that are associated with decreased bone density
such as the following: corticosteroids; anticonvulsants; thiazide diuretics; history
of cancer; Type I diabetes; thyrotoxicosis; hyperparathyroidism; Cushing's syndrome;
juvenil... | 2 | https://clinicaltrials.gov/show/NCT00000413 | 9 Years | 13 Years | Female |
NCT00000419 | Safety of Estrogens in Lupus: Hormone Replacement Therapy | Safety of Estrogens in Lupus Erythematosus - National Assessment (SELENA) is a study to test
whether postmenopausal women with systemic lupus erythematosus (SLE, or lupus) can safely use
the hormone estrogen. In this part of the study, we will look at the effects of estrogen
replacement therapy on ... | :
- Female
- Unequivocal diagnosis of SLE
- Inactive disease or stable on 0.5 mg/kg/day or less of prednisone
- Chemical evidence of menopause or have stopped periods for at least 6 months | :
- Blood pressure >145/95 on three occasions
- Deep vein, arterial thrombosis or pulmonary embolus
- GPL >40; MPL >40; APL >50; dRVVT >37 sec
- APL antibody syndrome ever
- Gynecologic or breast cancer
- Hepatic dysfunction or liver tu... | 3 | https://clinicaltrials.gov/show/NCT00000419 | 18 Years | 85 Years | Female |
NCT00000421 | Serologically Active, Clinically Stable Systemic Lupus Erythematosus | The first part of this study will use the database of a large, ongoing NIH-sponsored lupus
study, Safety of Estrogen in Lupus Erythematosus National Assessment. We will examine the
levels of a blood protein known as C3a in a series of patient blood samples to see if C3a
levels predict lupus flares ... | :
- Meets ACR criteria for SLE
- Inactive or stable in lupus activity
- History of positive dsDNA
- Current prednisone dose no more than 15 mg daily | :
- Active infections
- Poorly controlled diabetes mellitus
- Pregnancy
- Uncontrolled hypertension | 2 | https://clinicaltrials.gov/show/NCT00000421 | 13 Years | 65 Years | Female |
NCT00000424 | Tidal Lavage in Knee Osteoarthritis | This study compared the effects of tidal lavage (washing out) of the knee joint and an
imitation lavage procedure in people with knee osteoarthritis. In tidal lavage, the doctor
flushes out a knee joint with repeated injections of a mild salt solution, done under local
anesthesia. Study participant... | :
- Knee pain attributed to osteoarthritis for at least 1 year.
- Meet American College of Rheumatology clinical or clinical plus x-ray criteria for
knee osteoarthritis
- Have at least a moderate pain rating on at least one of the five Western
Ontari... | :
- Significant conditions of the spine, hips, or feet that affect the ability to walk
- Significant medical conditions that affect the ability to walk and function
- Inflammatory arthritis, such as rheumatoid arthritis or gout
- Degenerative arthritis secondary t... | 2 | https://clinicaltrials.gov/show/NCT00000424 | 40 Years | N/A | All |
NCT00000425 | Toward Better Outcomes in Osteoarthritis | This study will determine if there is a difference between commonly used nonsteroidal
anti-inflammatory drugs (NSAIDs) and acetaminophen (a pain-reliever that does not prevent
inflammation) for treating knee pain in osteoarthritis (OA). The two main results we will
look at are disease progression a... | :
- Knee osteoarthritis
- Moderate radiographic evidence by Kellgren and Lawrence grade 2-4
- Knee pain > 20 on VAS pain scale | :
- Bilateral knee replacements
- Unwillingness to take acetaminophen for pain relief | 3 | https://clinicaltrials.gov/show/NCT00000425 | 50 Years | 85 Years | All |
NCT00000427 | Effects of Parathyroid Hormone in Men With Osteoporosis | Alendronate is a drug that blocks or reduces bone loss, while parathyroid hormone (PTH)
stimulates the formation of new bone. The purpose of this study is to compare the
bone-building effects of PTH alone, alendronate alone, and both PTH and alendronate in men
with osteoporosis over a two-and-a-hal... | :
- Bone density of the spine or femoral neck two standard deviations below the mean of
young adult men
- Normal renal and liver function tests, normal serum testosterone level, normal vitamin
D and PTH levels | :
- Significant cardiac, renal, hepatic, or malignant disease.
- Disorders (e.g., Paget's disease, hyperthyroidism, hyperparathyroidism) or drugs
(e.g., steroids, anticonvulsants, lithium, bisphosphonates, calcitonin, fluoride)
known to affect bone metabolism
... | 3 | https://clinicaltrials.gov/show/NCT00000427 | 46 Years | 85 Years | Male |
NCT00000430 | Low-Dose Hormone Replacement Therapy and Alendronate for Osteoporosis | Osteoporosis, a condition in which bones are fragile and break easily, is a major health
problem for postmenopausal women. Research studies have shown that both estrogen/progestin
replacement therapy (hormone replacement therapy, or HRT) and alendronate are effective in
preventing and treating oste... | :
- Women at least 60 years of age.
- Good general health.
- Willingness to participate in this 3.5 year study.
- Ability to give informed consent.
- Ability to live independently and travel to the research center for visits (we will
pr... | :
- Any history of cancer except the following: (a) superficial basal or squamous cell
carcinoma of the skin which has been completely resected or resolved by a topical
chemotherapeutic agent, and (b) other malignancies treated curatively at least 10
years previou... | 3 | https://clinicaltrials.gov/show/NCT00000430 | 60 Years | N/A | Female |
NCT00000432 | Lyme Disease Prevention Program | This is a large study of an educational program on Lyme disease prevention for passengers on
ferry boats going to Nantucket Island during the period from Memorial Day until Labor Day.
Some boats provide passengers with the experimental program and the other boats provide a
"control" program that th... | :
- Ferry passengers traveling to Nantucket Island | :
- Foreign (non-U.S.) residence | 3 | https://clinicaltrials.gov/show/NCT00000432 | N/A | N/A | All |
NCT00000433 | Blocking Tumor Necrosis Factor in Ankylosing Spondylitis | The Division of Rheumatology at University of California San Francisco is conducting a
research study on the treatment of ankylosing spondylitis (AS) with a new therapy currently
used for people with other forms of arthritis. The drug, called Enbrel (or etanercept), is a
protein that is given twice... | :
- Diagnosis of Ankylosing spondylitis
- Acceptable stable treatments during study: oral glucocorticoids (less than or equal to
10 mg/d) and/or NSAIDs at recommended doses and/or one of the following options:
methotrexate (less than or equal to 20.0 mg/week); sul... | :
- Diagnosis of psoriatic arthritis, inflammatory bowel disease, reactive arthritis, or
Behýet disease
- Significant medical problems, such as diabetes mellitus
- History of active or recurrent infections
- Complete ankylosis of the entire spine | 2 | https://clinicaltrials.gov/show/NCT00000433 | 18 Years | 80 Years | All |
NCT00000435 | dnaJ Peptide for Relieving Rheumatoid Arthritis | A small protein called dnaJ peptide may help people with rheumatoid arthritis (RA) by
preventing their immune system cells from attacking their own tissues. The purpose of this
study is to determine if small amounts of dnaJ peptide can "re-educate" immune cells in
people with RA so that the cells s... | :
- Active rheumatoid arthritis as defined by the revised American College of Rheumatology
(ACR) 1987 criteria. Evidence of active disease will be based on at least six swollen
or nine tender joints.
- Diagnosis of rheumatoid arthritis of less than 5 years
... | :
- Patients taking more 7.5 mg of prednisone or disease modifying agents other than
hydrochloroquine or sulfasalazine (i.e., gold, penicillamine, azathioprine,
cyclophosphamide, methotrexate, cyclosporine, or anti-TNF agents)
- Serum creatinine greater than 1.5 m... | 2 | https://clinicaltrials.gov/show/NCT00000435 | 18 Years | 85 Years | All |
NCT00000437 | Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) | The purpose of this study is to determine the effectiveness of naltrexone (Revia) or matched
placebo combined with nicotine patch (Nicotrol) or placebo patch using a 2x2 design in
reducing drinking and smoking in patients with both nicotine and alcohol dependence. | :
- Meets criteria for alcohol dependence and nicotine dependence.
- Expresses a desire to cut down or stop drinking and smoking. | :
- Currently meets criteria for dependence on substances other than alcohol and nicotine.
- Any history of opiate dependence or evidence of current opiate use.
- Significant medical disorders that will increase potential risk or interfere with
study participation... | 4 | https://clinicaltrials.gov/show/NCT00000437 | 18 Years | 65 Years | All |
NCT00000461 | Harvard Atherosclerosis Reversibility Project (HARP) | To determine by sequential coronary arteriography whether a lipid-lowering diet with and
without lipid-lowering drugs could reverse coronary artery disease in normocholesterolemic
patients. Also, to test whether fish oil supplements could improve human coronary
atherosclerosis. Finally, to determin... | Men and women, normocholesterolemic, with 30 percent or greater narrowing of a coronary
artery lumen as revealed by angiography. (Cholesterol-Lowering Agent Trial).
Men and women with angiographically-documented coronary heart disease (Fish Oil Tr | null | 2 | https://clinicaltrials.gov/show/NCT00000461 | 18 Years | 75 Years | All |
NCT00000468 | Myocardial Infarction Triage and Intervention Project (MITI) | To determine the practicality, benefit, and safety of paramedic administration of
thrombolytic therapy for acute myocardial infarction. The feasibility of paramedics correctly
identifying candidates for thrombolytic therapy following myocardial infarction was assessed
in Phase I. In Phase II, pre-h... | Men and women, ages 35 to 71, with chest pain of between 15 minutes and 6 hours duration,
systolic blood pressure of more than 80 mm Hg and less than 200 mm Hg, and a diastolic
blood pressure of less than 120 mm Hg. (Phase I).
Men and women with m | null | 3 | https://clinicaltrials.gov/show/NCT00000468 | 35 Years | 71 Years | All |
NCT00000469 | Asymptomatic Carotid Artery Plaque Study (ACAPS) | To determine whether warfarin or lovastatin alone or in combination retarded the progression
of atherosclerotic plaques in the carotid arteries of high risk individuals with asymptomatic
carotid stenosis. Also, to determine if a full scale trial was feasible. | Men and women with early carotid atherosclerosis and moderately elevated LDL cholesterol
between the 60th and 90th percentiles. | null | 2 | https://clinicaltrials.gov/show/NCT00000469 | 40 Years | 79 Years | All |
NCT00000478 | Asymptomatic Cardiac Ischemia Pilot (ACIP) Study | To assess the feasibility of and test the methodology for a full-scale clinical trial of
therapies for asymptomatic cardiac ischemia. | Men aand women with angiographically documented coronary artery disease, ischemia on both
stress (exercise) testing and 48-hour ambulatory electrocardiogram monitoring, and who were
amenable to revascularization. | null | 3 | https://clinicaltrials.gov/show/NCT00000478 | 18 Years | 75 Years | All |
NCT00000479 | Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer | The purpose of this study is to evaluate the effects of low-dose aspirin and vitamin E in
primary prevention of cardiovascular disease and cancer in apparently healthy women. | :
- Healthy women
- No previous history of cardiovascular disease or cancer
- No contraindications to aspirin or vitamin E | null | 3 | https://clinicaltrials.gov/show/NCT00000479 | 45 Years | N/A | Female |
NCT00000481 | Women's Health Trial: Feasibility Study in Minority Populations | To evaluate the feasibility of recruiting women of different socioeconomic status and
minority groups and to determine whether these women could achieve and maintain a modified
fat-eating pattern. The full-scale trial sought to determine whether a low-fat diet could
decrease the incidence of cancer... | Postmenopausal women, aged 50 to 69 years, who consumed 38 percent or more of total
calories as fat at baseline. | null | 3 | https://clinicaltrials.gov/show/NCT00000481 | 50 Years | 69 Years | Female |
NCT00000482 | Coronary Drug Project | To determine whether regular administration of lipid modifying drugs (clofibrate, nicotinic
acid, estrogen, dextrothyroxine) to men with a documented myocardial infarction would result
in significant reduction in total mortality over a five year period. Secondarily, to
determine whether the degree ... | Men, ages 30-64. Three months beyond most recent myocardial infarction. | null | 3 | https://clinicaltrials.gov/show/NCT00000482 | 30 Years | 64 Years | Male |
NCT00000487 | Multiple Risk Factor Intervention Trial for the Prevention of Coronary Heart Disease (MRFIT) | To determine for a group of men at high risk of death from coronary heart disease whether a
special intervention program to lower serum cholesterol, reduce blood pressure, and eliminate
cigarette smoking would result in a significant reduction in mortality from coronary heart
disease. | Men, ages 35-57. One or more of three risk factors--hypertension, hypercholesterolemia, and
cigarette smoking.
Free from coronary heart disease. | null | 3 | https://clinicaltrials.gov/show/NCT00000487 | 35 Years | 57 Years | Male |
NCT00000493 | Multicenter Investigation of Limitation of Infarct Size (MILIS) | To assess the ability of two separate therapeutic interventions, propranolol and
hyaluronidase, to limit the ultimate size of an acute myocardial infarction. A secondary
objective was to assess the influence of these therapies upon ventricular function and
morbidity following myocardial infarction. | Men and women, under age 75. Documented myocardial infarction which could be treated within
18 hours of onset of ischemic symptoms. | null | 3 | https://clinicaltrials.gov/show/NCT00000493 | 18 Years | 74 Years | All |
NCT00000497 | Dietary Intervention Study for Hypertension (DISH) | The primary objective of this multicenter cooperative clinical trial was to determine if
dietary modification would enable drug controlled hypertensive patients to remain at 'goal
blood pressures' after antihypertensive medication was withdrawn. The proposal made use of
the HDFP hypertensive popula... | Men and women with hypertension. Diastolic blood pressure equal to or above 95 mm Hg and 90
mm Hg, respectively for home and clinic readings. | null | 3 | https://clinicaltrials.gov/show/NCT00000497 | 40 Years | N/A | All |
NCT00000498 | Control of Hypertension by Non-Pharmacologic Means | To determine whether blood pressure could be controlled by nutritional-hygienic,
non-pharmacologic means in hypertensives treated with drugs in the Hypertension Detection and
Follow-up Trial (HDFP). | Men and women with controlled hypertension. | null | 3 | https://clinicaltrials.gov/show/NCT00000498 | 40 Years | 100 Years | All |
NCT00000501 | Hypertension Prevention Trial (HPT) Feasibility Study | To test the feasibility and the efficacy of nutritional interventions in the primary
prevention of hypertension in individuals predisposed to the development of hypertension;
specifically, to test the hypothesis that reduction of weight and/or decreased sodium intake
in obese individuals, or decrea... | Men and women, ages 25 to 49. Diastolic blood pressure between 78 and 89 mm Hg. Free of
major disease. Not on a special diet or antihypertensive medication at entry. Some mild to
moderately obese subjects. | null | 2 | https://clinicaltrials.gov/show/NCT00000501 | 25 Years | 49 Years | All |
NCT00000502 | Evaluation of SC-V Versus Conventional CPR | To assess the benefits of a new method of cardiopulmonary resuscitation, SC-V CPR
(simultaneous compression and ventilation CPR) in terms of short and long-term survival and
lessened cerebral dysfunction. | Men, women, and children in cardiac arrest for which CPR was initiated in ten minutes or
less from the time of arrest. | null | 3 | https://clinicaltrials.gov/show/NCT00000502 | 18 Years | 75 Years | All |
NCT00000513 | Trial of Antihypertensive Intervention Management | The objective of the Trial of Antihypertensive Intervention Management (TAIM) was to
determine the efficacy of dietary management and/or drug therapy, namely thiazide-like
diuretics or a beta-blocker, in the control of mild hypertension. Additionally, the
Continuation of the Trial of Antihypertensi... | Men and women, ages 21 to 65, with mild hypertension in the range of 90 to 100 mm Hg
diastolic blood pressure.
Subjects were obese (110-150 percent of ideal weight). | null | 3 | https://clinicaltrials.gov/show/NCT00000513 | 21 Years | 65 Years | All |
NCT00000514 | Systolic Hypertension in the Elderly Program (SHEP) | The primary objective was to assess whether long-term administration of antihypertensive
therapy to elderly subjects with isolated systolic hypertension reduced the combined
incidence of fatal and non-fatal stroke. The secondary objectives were to evaluate: the
effect of long-term antihypertensive ... | Men and women, aged 60 or over, with isolated systolic hypertension. | null | 3 | https://clinicaltrials.gov/show/NCT00000514 | 60 Years | 100 Years | All |
NCT00000515 | Randomized Trial of Dietary Intervention Therapy in Obese Hypertensives (DITOH) | To determine the effects on blood pressure of dietary intervention, restricting caloric
intake to 600 calories per day for 16 weeks compared to a control diet of 1200 calories per
day in obese hypertensives. Secondary aims included a study of psychological characteristics
at baseline and during the... | Men and women, ages 25 to 55. Subjects were obese, weighing between 130 and 210 percent of
ideal body weight. Subjects had diastolic blood pressures between 90 and 105 mm Hg and were
not on antihypertensive medications. | null | 3 | https://clinicaltrials.gov/show/NCT00000515 | 25 Years | 55 Years | All |
NCT00000516 | Studies of Left Ventricular Dysfunction (SOLVD) | To determine if enalapril treatment of left ventricular dysfunction (LVD) due to ischemic or
hypertensive heart disease led to reduced mortality and morbidity in symptomatic and
asymptomatic patients. There were a Prevention Trial, a Treatment Trial, and a registry. | Men and women, ages 21 to 80. Subjects were asymptomatic or symptomatic and had ejection
fractions equal to or below 35 percent. | null | 3 | https://clinicaltrials.gov/show/NCT00000516 | 21 Years | 80 Years | All |
NCT00000517 | Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF) | To determine the benefits and risks of oral anticoagulant therapy in reducing embolic stroke
and systemic emboli in patients with atrial fibrillation without rheumatic heart disease. | Men and women, 18 years of age or older, with non-rheumatic atrial fibrillation. | null | 3 | https://clinicaltrials.gov/show/NCT00000517 | 18 Years | N/A | All |
NCT00000518 | Electrophysiologic Study Versus Electrocardiographic Monitoring (ESVEM) | To determine whether electrophysiologic study (EPS) or Holter monitoring (HM) was the better
method for selecting effective long-term antiarrhythmic drug therapy in patients with
sustained ventricular tachycardia, ventricular fibrillation, or an episode of aborted sudden
death. | Men and women with documented ventricular tachycardia and those resuscitated from sudden
death. | null | 3 | https://clinicaltrials.gov/show/NCT00000518 | 18 Years | 75 Years | All |
NCT00000519 | Exercise Training and Plasma Lipoproteins in Man | To determine the effects in moderately obese subjects of weight loss by combined dieting and
exercise training on risk factors for coronary artery disease including lipoprotein lipids,
apoproteins and blood pressure. | Men and women, ages 25-49. Subjects were overweight with blood pressure less than 160/95 mm
Hg and total cholesterol less than 260 mm/dl. | null | 3 | https://clinicaltrials.gov/show/NCT00000519 | 25 Years | 49 Years | All |
NCT00000520 | Prevention of Coronary Aneurysms in Kawasaki Syndrome | To test the efficacy of intravenous gamma globulin (IVGG) in preventing coronary artery
aneurysms in children with Kawasaki Syndrome. | Boys and girls who met the CDC criteria for Kawasaki Syndrome. Subjects were excluded if
they presented themselves to the participating centers after the tenth day of illness. | null | 2 | https://clinicaltrials.gov/show/NCT00000520 | 1 Year | 17 Years | All |
NCT00000521 | Sodium-Potassium Blood Pressure Trial in Children | To examine the effects of nutritional intervention on the rate of rise of blood pressure in
late childhood and early adolescence. | Children in grades 5 through 8 whose systolic blood pressure was greater than or equal to
120 mm Hg on two visits. | null | 4 | https://clinicaltrials.gov/show/NCT00000521 | 10 Years | 13 Years | All |
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