wasifis/ade-dataset · Datasets at Hugging Face

drugname stringlengths 2 49	drugreaction stringlengths 2 82	text stringlengths 18 476
alprazolam	Changes in the plasma cortisol level	1 . Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment ( mean 0.62 +/- 0.15 mg/day ) compared with during the period of high-dose period ( mean 1.08 +/- 0.28 mg/day ) .
alprazolam	decreased plasma cortisol level	3 . Thus , the decreased plasma cortisol level during alprazolam treatment of panic disorder was suggested to be caused not by symptom alleviation due to alprazolam but by alprazolam administration itself .
lorazepam	seizures	A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported .
adenosine	acceleration of the heart rate	A 12 year old patient with atrial flutter is presented , in whom intravenous adenosine was followed by acceleration of the heart rate to a potentially dangerous arrhythmia .
ibuprofen	15-kg weight gain	A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy .
phenytoin	unilateral gingival hyperplasia	A 15-year follow-up of phenytoin -induced unilateral gingival hyperplasia : a case report .
tryptophan	eosinophilia myalgia syndrome	A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan , which were given during his initial induction chemotherapy and also after autologous marrow transplantation .
minocycline	eruption	A 17-year-old female patient who had been taking oral minocycline ( 50 mg twice daily ) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis .
zonisamide	heat stroke	A 2-year-old mentally retarded boy with frontal lobe epilepsy presented with an episode that resembled heat stroke during the administration of zonisamide .
clozapine	rhabdomyolysis	A 21-year-old patient developed rhabdomyolysis during his nineteenth week of treatment with clozapine for drug-resistant schizophrenia .
ibuprofen	severe hypersensitivity reaction	A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen .
methysergide	retroperitoneal fibrosis	A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide .
risperidone	dyskinetic movements	A 28 year old white schizophrenic male has been under risperidone monotherapy for about one year when he developed dyskinetic movements .
fenclofenac	IgA deficiency	A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac .
enalapril	acute renal failure	A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril .
bleomycin	left homonymous hemianopsia	A 36-year-old man being treated with cisplatinum , vinblastine , and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia , encephalopathy , and a partial nondominant parietal lobe syndrome .
MTX	overwhelming hepatic necrosis	A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis .
bleomycin	interstitial pneumonitis	A 42 year old man , treated for testicular carcinoma with combination chemotherapy that included bleomycin , developed life threatening interstitial pneumonitis .
methotrexate	erosion of a psoriatic plaque	A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate .
amiodarone	atypical ventricular tachycardia	A 44-year-old woman is described in whom amiodarone , disopyramide , and quinidine , administered alone separately , induced atypical ventricular tachycardia ( AVT , torsade de pointes ) .
propylthiouracil	agranulocytosis	A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil .
pentazocine	gradual stiffness	A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities , developed gradual stiffness and weakness of the lower extremities .
5-ASA	worsening respiratory distress	A 49-year-old man with Crohn 's disease treated with prednisone and mesalamine ( 5-ASA ) developed worsening respiratory distress and fever .
captopril	attacks of asthma	A 51-yr-old nonsmoking male patient without any history of previous allergies , asthma , hay fever , or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure .
sodium aurothiomalate	low-grade fever	A 52-year-old , white female developed low-grade fever , cough , and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis .
phenytoin	transient hemiparesis	A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury .
bromocriptine	schizophrenia	A 53-year-old male , without any prior history of psychosis , developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma .
amiodarone	thyrotoxicosis	A 54-year-old man , treated with amiodarone , developed thyrotoxicosis .
lamotrigine	TEN	A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor .
methyldopa	hepatitis	A 55-year-old woman developed symptoms suggestive of hepatitis 12 weeks after first receiving methyldopa for hypertension .
thiabendazole	prolonged jaundice	A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy .
cinepazide	behavioral change	A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide , a cerebral vasodilator .
D-penicillamine	rapidly progressive glomerulonephritis	A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g .
interferon beta	pulmonary sarcoidosis	A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes .
nifedipine	dysphagia for solids	A 57-year-old woman presented with a 3-week history of dysphagia for solids , 6 months after starting treatment with nifedipine .
Norpace	complete heart block	A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block ( CHB ) following administration of disopyramide phosphate ( Norpace ) .
streptokinase	ischaemic cerebrovascular accident	A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli .
gold	lichen planus	A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold .
scopolamine	unilateral acute angle-closure glaucoma	A 58-year-old woman developed unilateral acute angle-closure glaucoma four days after the application of a patch of transdermal scopolamine delivery system ( TRANSDERM-V ) .
theophylline	gynecomastia	A 61 year-old male patient developed gynecomastia after starting theophylline .
procainamide	clinical lupus syndrome	A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody , positive lupus erythematosus ( LE ) cell preparation , and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy .
metformin	miliary tuberculosis	A 62-year-old Indian with diabetic nephropathy controlled with metformin , developed miliary tuberculosis for which he was treated with rifampicin , isoniazid and ethambutol .
MTX	severe skin rash	A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days , respectively , following a single dose of 40 mg/m2 methotrexate ( MTX ) .
Amphojel	small-bowel obstruction	A 65-year-old woman , in the intensive care unit because of septic shock and acute renal failure , had a small-bowel obstruction due to Amphojel concretions .
isosorbide dinitrate	syncope	A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate ( 5 mg ) .
lithium	movement disorder	A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression .
digoxin	complete atrioventricular block	A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments .
ampicillin	diarrhea	A 67-year-old man developed diarrhea shortly after a 10-day course of oral ampicillin .
fenoprofen	pure red cell aplasia	A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months .
2-propylpentanoic acid	severe unilateral grand mal seizure	A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years ( phenobarbitone therapy ) ; 1.5 years later valproate ( 2-propylpentanoic acid , VPA ) was added to the therapy .
procainamide	granulocytopenia	A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide ( 750 mg/day ) .
flecainide	acute reversible encephalopathy	A 73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide .
vincristine	sensori-neural hearing loss	A 73-year-old woman with non-Hodgkin 's lymphoma had two episodes of severe , bilateral , sensori-neural hearing loss after vincristine therapy .
procainamide	shocks	A 78-year-old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy .
acyclovir	acute renal failure	A 9-year-old boy developed acute renal failure following intravenous acyclovir ( 30 mg/kg per day ) administered for 6 days to treat herpetic encephalitis .
cyclosporine	hypersensitivity reactions	A MEDLINE search identified all the reported cases of hypersensitivity reactions to cyclosporine .
chloramphenicol	hypersensitivity	A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature , as well as possible alternative explanations in this case , are provided .
deanol	tardive dyskinesia	A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented .
minoxidil	fatal interaction	A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder .
IL-2	cognitive dysfunction	A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction .
BCNU	fatal pulmonary fibrosis	A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy .
ticlopidine	febrile agranulocytosis	A case is reported of an elderly woman who developed febrile agranulocytosis several weeks after commencing ticlopidine but who had a favorable outcome after cessation of that drug and treatment with filgastrim .
theophylline	theophylline intoxication	A case is reported of theophylline intoxication theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine .
Rifampicin	Erythema Multiforme Bullosum	A case of Erythema Multiforme Bullosum in patient of lepromatous leprosy with pulmonary tuberculosis due to Rifampicin is described .
desipramine	SIADH	A case of SIADH associated with desipramine treatment in an elderly depressed woman is described .
choline magnesium trisalicylate	hepatotoxicity	A case of a 21-year-old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described .
aspirin	acute subdural haematoma	A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented .
allopurinol	hypersensitivity	A case of allopurinol hypersensitivity , possibly the first in a black African , is reported .
barbiturate	submassive hepatic necrosis	A case of barbiturate -induced submassive hepatic necrosis is presented and the literature is reviewed .
phenytoin	basilar invagination	A case of basilar invagination which is thought to have arisen from the patient 's intrauterine exposure to phenytoin is presented .
sodium bisulfite	contact dermatitis	A case of contact dermatitis due to sodium bisulfite in an ophthalmic solution .
fluoxetine	seizures	A case of fluoxetine induced seizures , in a person with Down syndrome , is described .
halothane	hepatitis	A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity .
fluoxetine	mania	A case of mania associated with fluoxetine .
ethanolamine oleate	noncardiogenic pulmonary edema	A case of noncardiogenic pulmonary edema by ethanolamine oleate .
phenytoin	hepatitis	A case of phenytoin -induced hepatitis with mononucleosis is reported , and syndromes associated with phenytoin hypersensitivity reactions are discussed .
trazodone	priapism	A case of priapism associated with trazodone is described .
suxamethonium	apnoea	A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported .
propranolol	esophageal spasm	A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented .
pyridoxine	seizures	A case of pyridoxine -dependent seizures is reported .
vincristine	severe visual loss	A case of severe visual loss following a single dose of vincristine is described .
niflumic acid	skeletal fluorosis	A case of skeletal fluorosis induced by prolonged treatment with niflumic acid , a fast-acting non-steroid antiinflammatory agent , is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated , in addition , with corticosteroids .
timolol	heart failure	A case of timolol -associated heart failure in a 73-year old white man is reported .
etretinate	toxic hepatitis	A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman .
protamine	pulmonary vasoconstriction	A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement .
dapsone	hypersensitivity syndrome	A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented .
phenobarbital	hypersensitivity	A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever , a pruritic desquamating erythrodermic rash , alopecia , icterus , protein-losing enteropathy , myositis , and nephritis , is described .
nitrofurantoin	pulmonary fibrosis	A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis .
human growth hormone	Creutzfeldt-Jakob disease	A clinically atypical , neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence ( 1970 to 1973 ) with human growth hormone processed from pooled cadaveric pituitary glands .
dapsone	hypersensitivity syndrome	A dapsone hypersensitivity syndrome , consisting of fever , headache , nausea , vomiting , lymphadenopathy , hepatitis , hemolysis , leukopenia , and mononucleosis , has been described in patients treated with the drug for leprosy .
fluoxetine	manic episode	A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine .
methicillin	massive proteinuria	A drug addict with staphylococcal endocarditis treated with methicillin , who developed massive proteinuria and acute nephritic syndrome is described .
theophylline	drug interaction	A drug interaction between zafirlukast and theophylline .
levomepromazine	fatal case of pancytopenia	A fatal case of pancytopenia due to levomepromazine .
streptokinase	fatal massive pulmonary embolus	A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis .
diazepam	fatal pancytopenia	A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds , admitted for a manic episode and treated with levomepromazine , diazepam and lithium carbonate .
methylprednisolone	anaphylactoid reaction	A further case of anaphylactoid reaction to methylprednisolone is reported .
sulindac	isolated idential sensory neuropathy	A healthy , 30-year-old man , exposed to sulindac on two separate occasions , had an incapacitating isolated idential sensory neuropathy .
cotrimoxazole	hyperkalaemia	A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea , and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients ; one patient became unconscious .
vasopressin	lethal complication	A lethal complication of peripheral vein vasopressin infusion .

alprazolam

Changes in the plasma cortisol level

1 . Changes in the plasma cortisol level were reported in a male patient with panic disorder during the period of low-dose alprazolam treatment ( mean 0.62 +/- 0.15 mg/day ) compared with during the period of high-dose period ( mean 1.08 +/- 0.28 mg/day ) .

alprazolam

decreased plasma cortisol level

3 . Thus , the decreased plasma cortisol level during alprazolam treatment of panic disorder was suggested to be caused not by symptom alleviation due to alprazolam but by alprazolam administration itself .

lorazepam

seizures

A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported .

adenosine

acceleration of the heart rate

A 12 year old patient with atrial flutter is presented , in whom intravenous adenosine was followed by acceleration of the heart rate to a potentially dangerous arrhythmia .

ibuprofen

15-kg weight gain

A 15-kg weight gain developed in a patient during the third week of ibuprofen therapy .

phenytoin

unilateral gingival hyperplasia

A 15-year follow-up of phenytoin -induced unilateral gingival hyperplasia : a case report .

tryptophan

eosinophilia myalgia syndrome

A 16-year-old white male with acute biphenotypic leukemia developed evidence of the eosinophilia myalgia syndrome associated with total parenteral nutritional support with solutions containing tryptophan , which were given during his initial induction chemotherapy and also after autologous marrow transplantation .

minocycline

eruption

A 17-year-old female patient who had been taking oral minocycline ( 50 mg twice daily ) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis .

zonisamide

heat stroke

A 2-year-old mentally retarded boy with frontal lobe epilepsy presented with an episode that resembled heat stroke during the administration of zonisamide .

clozapine

rhabdomyolysis

A 21-year-old patient developed rhabdomyolysis during his nineteenth week of treatment with clozapine for drug-resistant schizophrenia .

ibuprofen

severe hypersensitivity reaction

A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen .

methysergide

retroperitoneal fibrosis

A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide .

risperidone

dyskinetic movements

A 28 year old white schizophrenic male has been under risperidone monotherapy for about one year when he developed dyskinetic movements .

fenclofenac

IgA deficiency

A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac .

enalapril

acute renal failure

A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril .

bleomycin

left homonymous hemianopsia

A 36-year-old man being treated with cisplatinum , vinblastine , and bleomycin for testicular carcinoma developed a dense left homonymous hemianopsia , encephalopathy , and a partial nondominant parietal lobe syndrome .

MTX

overwhelming hepatic necrosis

A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis .

bleomycin

interstitial pneumonitis

A 42 year old man , treated for testicular carcinoma with combination chemotherapy that included bleomycin , developed life threatening interstitial pneumonitis .

methotrexate

erosion of a psoriatic plaque

A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate .

amiodarone

atypical ventricular tachycardia

A 44-year-old woman is described in whom amiodarone , disopyramide , and quinidine , administered alone separately , induced atypical ventricular tachycardia ( AVT , torsade de pointes ) .

propylthiouracil

agranulocytosis

A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil .

pentazocine

gradual stiffness

A 47 year-old woman who had a 4-year history of intramuscular pentazocine injections in the lower extremities , developed gradual stiffness and weakness of the lower extremities .

5-ASA

worsening respiratory distress

A 49-year-old man with Crohn 's disease treated with prednisone and mesalamine ( 5-ASA ) developed worsening respiratory distress and fever .

captopril

attacks of asthma

A 51-yr-old nonsmoking male patient without any history of previous allergies , asthma , hay fever , or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure .

sodium aurothiomalate

low-grade fever

A 52-year-old , white female developed low-grade fever , cough , and dyspnea after 8 weeks treatment with sodium aurothiomalate for rheumatoid arthritis .

phenytoin

transient hemiparesis

A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury .

bromocriptine

schizophrenia

A 53-year-old male , without any prior history of psychosis , developed schizophrenia 4 days after starting low-dose bromocriptine therapy for a macroprolactinoma .

amiodarone

thyrotoxicosis

A 54-year-old man , treated with amiodarone , developed thyrotoxicosis .

lamotrigine

TEN

A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor .

methyldopa

hepatitis

A 55-year-old woman developed symptoms suggestive of hepatitis 12 weeks after first receiving methyldopa for hypertension .

thiabendazole

prolonged jaundice

A 55-yr-old man developed prolonged jaundice and sicca complex after a course of thiabendazole therapy .

cinepazide

behavioral change

A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide , a cerebral vasodilator .

D-penicillamine

rapidly progressive glomerulonephritis

A 56-year-old woman with scleroderma developed rapidly progressive glomerulonephritis with epithelial crescents associated with hemoptysis after 27 months of D-penicillamine therapy and a cumulative dose of 1,200 g .

interferon beta

pulmonary sarcoidosis

A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes .

nifedipine

dysphagia for solids

A 57-year-old woman presented with a 3-week history of dysphagia for solids , 6 months after starting treatment with nifedipine .

Norpace

complete heart block

A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block ( CHB ) following administration of disopyramide phosphate ( Norpace ) .

streptokinase

ischaemic cerebrovascular accident

A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli .

gold

lichen planus

A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold .

scopolamine

unilateral acute angle-closure glaucoma

A 58-year-old woman developed unilateral acute angle-closure glaucoma four days after the application of a patch of transdermal scopolamine delivery system ( TRANSDERM-V ) .

theophylline

gynecomastia

A 61 year-old male patient developed gynecomastia after starting theophylline .

procainamide

clinical lupus syndrome

A 61-year-old man developed clinical lupus syndrome with positive antinuclear antibody , positive lupus erythematosus ( LE ) cell preparation , and diffuse proliferative glomerulonephritis following 26 months of procainamide therapy .

metformin

miliary tuberculosis

A 62-year-old Indian with diabetic nephropathy controlled with metformin , developed miliary tuberculosis for which he was treated with rifampicin , isoniazid and ethambutol .

MTX

severe skin rash

A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days , respectively , following a single dose of 40 mg/m2 methotrexate ( MTX ) .

Amphojel

small-bowel obstruction

A 65-year-old woman , in the intensive care unit because of septic shock and acute renal failure , had a small-bowel obstruction due to Amphojel concretions .

isosorbide dinitrate

syncope

A 65-year-old woman with angina pectoris presented with syncope after sublingual ingestion of isosorbide dinitrate ( 5 mg ) .

lithium

movement disorder

A 65-year-old woman with bipolar disorder and complicated cardiovascular disease who was on maintenance lithium therapy developed a movement disorder following high doses of trazodone for treatment of an acute depression .

digoxin

complete atrioventricular block

A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments .

ampicillin

diarrhea

A 67-year-old man developed diarrhea shortly after a 10-day course of oral ampicillin .

fenoprofen

pure red cell aplasia

A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months .

2-propylpentanoic acid

severe unilateral grand mal seizure

A 7-year-old boy developed a severe unilateral grand mal seizure at the age of 5 years ( phenobarbitone therapy ) ; 1.5 years later valproate ( 2-propylpentanoic acid , VPA ) was added to the therapy .

procainamide

granulocytopenia

A 71-year-old man with paroxysmal atrial fibrillation who had a previous anterior myocardial infarction exhibited granulocytopenia 8 days following the administration of oral sustained-release procainamide ( 750 mg/day ) .

flecainide

acute reversible encephalopathy

A 73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide .

vincristine

sensori-neural hearing loss

A 73-year-old woman with non-Hodgkin 's lymphoma had two episodes of severe , bilateral , sensori-neural hearing loss after vincristine therapy .

procainamide

shocks

A 78-year-old man with a transvenous cardioverter defibrillator system developed frequent shocks during oral procainamide therapy .

acyclovir

acute renal failure

A 9-year-old boy developed acute renal failure following intravenous acyclovir ( 30 mg/kg per day ) administered for 6 days to treat herpetic encephalitis .

cyclosporine

hypersensitivity reactions

A MEDLINE search identified all the reported cases of hypersensitivity reactions to cyclosporine .

chloramphenicol

hypersensitivity

A brief review of reported cases of chloramphenicol hypersensitivity in the English-language literature , as well as possible alternative explanations in this case , are provided .

deanol

tardive dyskinesia

A case history of a 15-year-old boy who developed incapacitating tardive dyskinesia that resolved during treatment with deanol is presented .

minoxidil

fatal interaction

A case is presented which illustrates a probably fatal interaction between minoxidil and a coagulation disorder .

IL-2

cognitive dysfunction

A case is reported of a 40 year old woman treated with intraventricular IL-2 for leptomeningeal disease who developed progressive cognitive dysfunction .

BCNU

fatal pulmonary fibrosis

A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy .

ticlopidine

febrile agranulocytosis

A case is reported of an elderly woman who developed febrile agranulocytosis several weeks after commencing ticlopidine but who had a favorable outcome after cessation of that drug and treatment with filgastrim .

theophylline

theophylline intoxication

A case is reported of theophylline intoxication theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine .

Rifampicin

Erythema Multiforme Bullosum

A case of Erythema Multiforme Bullosum in patient of lepromatous leprosy with pulmonary tuberculosis due to Rifampicin is described .

desipramine

SIADH

A case of SIADH associated with desipramine treatment in an elderly depressed woman is described .

choline magnesium trisalicylate

hepatotoxicity

A case of a 21-year-old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described .

aspirin

acute subdural haematoma

A case of acute subdural haematoma originating spontaneously from an angiomatous meningioma in a patient receiving prophylactic aspirin therapy is presented .

allopurinol

hypersensitivity

A case of allopurinol hypersensitivity , possibly the first in a black African , is reported .

barbiturate

submassive hepatic necrosis

A case of barbiturate -induced submassive hepatic necrosis is presented and the literature is reviewed .

phenytoin

basilar invagination

A case of basilar invagination which is thought to have arisen from the patient 's intrauterine exposure to phenytoin is presented .

sodium bisulfite

contact dermatitis

A case of contact dermatitis due to sodium bisulfite in an ophthalmic solution .

fluoxetine

seizures

A case of fluoxetine induced seizures , in a person with Down syndrome , is described .

halothane

hepatitis

A case of halothane induced hepatitis is reported in a middle aged woman who underwent gastric surgery for morbid obesity .

fluoxetine

mania

A case of mania associated with fluoxetine .

ethanolamine oleate

noncardiogenic pulmonary edema

A case of noncardiogenic pulmonary edema by ethanolamine oleate .

phenytoin

hepatitis

A case of phenytoin -induced hepatitis with mononucleosis is reported , and syndromes associated with phenytoin hypersensitivity reactions are discussed .

trazodone

priapism

A case of priapism associated with trazodone is described .

suxamethonium

apnoea

A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported .

propranolol

esophageal spasm

A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented .

pyridoxine

seizures

A case of pyridoxine -dependent seizures is reported .

vincristine

severe visual loss

A case of severe visual loss following a single dose of vincristine is described .

niflumic acid

skeletal fluorosis

A case of skeletal fluorosis induced by prolonged treatment with niflumic acid , a fast-acting non-steroid antiinflammatory agent , is reported in a 35-year-old woman suffering from rheumatoid arthritis and treated , in addition , with corticosteroids .

timolol

heart failure

A case of timolol -associated heart failure in a 73-year old white man is reported .

etretinate

toxic hepatitis

A case of toxic hepatitis caused by combination therapy with methotrexate and etretinate in the treatment of severe psoriasis is presented in a 47-year-old woman .

protamine

pulmonary vasoconstriction

A case report is presented concerning the administration of ketanserin in the treatment of pulmonary vasoconstriction and right ventricular failure following the infusion of protamine in a patient undergoing coronary artery bypass surgery and mitral valve replacement .

dapsone

hypersensitivity syndrome

A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented .

phenobarbital

hypersensitivity

A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever , a pruritic desquamating erythrodermic rash , alopecia , icterus , protein-losing enteropathy , myositis , and nephritis , is described .

nitrofurantoin

pulmonary fibrosis

A chronic reaction associated with long-term treatment with nitrofurantoin has also been reported and causes irreversible pulmonary fibrosis .

human growth hormone

Creutzfeldt-Jakob disease

A clinically atypical , neuropathologically verified case of Creutzfeldt-Jakob disease is described in a 32-year-old New Zealand woman with idiopathic hypopituitarism who had been treated in late adolescence ( 1970 to 1973 ) with human growth hormone processed from pooled cadaveric pituitary glands .

dapsone

hypersensitivity syndrome

A dapsone hypersensitivity syndrome , consisting of fever , headache , nausea , vomiting , lymphadenopathy , hepatitis , hemolysis , leukopenia , and mononucleosis , has been described in patients treated with the drug for leprosy .

fluoxetine

manic episode

A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine .

methicillin

massive proteinuria

A drug addict with staphylococcal endocarditis treated with methicillin , who developed massive proteinuria and acute nephritic syndrome is described .

theophylline

drug interaction

A drug interaction between zafirlukast and theophylline .

levomepromazine

fatal case of pancytopenia

A fatal case of pancytopenia due to levomepromazine .

streptokinase

fatal massive pulmonary embolus

A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis .

diazepam

fatal pancytopenia

A fatal pancytopenia occurred in a patient with an history of depression with hypomanic rebounds , admitted for a manic episode and treated with levomepromazine , diazepam and lithium carbonate .

methylprednisolone

anaphylactoid reaction

A further case of anaphylactoid reaction to methylprednisolone is reported .

sulindac

isolated idential sensory neuropathy

A healthy , 30-year-old man , exposed to sulindac on two separate occasions , had an incapacitating isolated idential sensory neuropathy .

cotrimoxazole

hyperkalaemia

A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea , and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients ; one patient became unconscious .

vasopressin

lethal complication

A lethal complication of peripheral vein vasopressin infusion .