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niflumic acid

fluorosis

After ruling out a hydrotelluric source of fluorine , the patient 's fluorosis was linked to chronic use of niflumic acid , following the publication in 1978 of the 2 previously reported cases affected by this drug .

cholestyramine II

lethargy

After taking cholestyramine II sachets twice daily for two months she presented with lethargy , confusion and drowsiness .

rifampicin

skin lesions

After the patient discontinued rifampicin , the skin lesions cleared completely within 5 weeks without any systemic medication .

cresol

increasing myalgia

After therapy for diabetic coma with insulin ( containing the preservative cresol ) and electrolyte solutions was started , the patient complained of increasing myalgia , developed a high fever and respiratory and metabolic acidosis and lost consciousness .

amiodarone

jaundice

After therapy with parenteral amiodarone ( 2300 mg in 3 days ) and other measures , signs of congestive heart failure disappeared ; subsequently the patient developed jaundice , marked increase in serum transaminase levels and fall in prothrombin time , and histologic changes of severe centrilobular necrosis were observed in hepatic biopsy .

cimetidine

decreased oxygen saturation and arterial PO2

After treatment with cimetidine , there was a rapid deterioration with decreased oxygen saturation and arterial PO2 values .

doxorubicin

cardiomyopathy

Aggressive management of doxorubicin -induced cardiomyopathy associated with 'low ' doses of doxorubicin .

ticlopidine

Agranulocytosis

Agranulocytosis associated with ticlopidine : a possible benefit with filgastim .

lithium

thyroid dysfunctions

Albeit rare among Western patients , such lithium -associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese .

Albendazole

pseudomembranous colitis

Albendazole -induced pseudomembranous colitis .

Albuterol

hypokalemia

Albuterol -induced hypokalemia and its potential cardiac toxicity are discussed briefly .

gold

mucocutaneous side effects

All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy , at a time when RA had improved markedly compared to pretreatment status .

benzoin

Allergic contact dermatitis

Allergic contact dermatitis to compound tincture of benzoin .

Allopurinol

hand and foot deformities

Allopurinol -associated hand and foot deformities in chronic tophaceous gout .

Allopurinol

hypersensitivity

Allopurinol hypersensitivity .

cyclophosphamide

Alopecia

Alopecia , nausea , and vomiting were attributed to the cyclophosphamide component of the therapy .

propranolol

Alternating sinus rhythm

Alternating sinus rhythm and intermittent sinoatrial ( S-A ) block was observed in a 57-year-old woman , under treatment for angina with 80 mg propranolol daily .

propranolol

Alternating sinus rhythm

Alternating sinus rhythm and intermittent sinoatrial block induced by propranolol .

metronidazole

pseudomembranous colitis

Although a few case reports link metronidazole with the development of pseudomembranous colitis , albendazole has not been associated with the development of this condition .

protamine

type I anaphylaxis

Although adverse reactions to protamine are reported infrequently and are usually mild , we recently observed the first fatal case of type I anaphylaxis resulting from protamine .

cisplatin

colitis

Although both patients recovered from the colitis after the administration of vancomycin , the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin .

vincristine

severe visual loss

Although differential diagnostic alternatives can be considered in all described cases it is very likely that vincristine does cause severe visual loss in a small number of patients .

verapamil

dyspnea

Although dyspnea associated with verapamil administration has been reported , this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration .

fluoxetine

headache

Although fluoxetine -induced headache occurred in one patient , the other five reported no side effects at the doses used .

tamoxifen

proliferative lesions of the endometrium

Although its side effects are few , tamoxifen increases the incidence of proliferative lesions of the endometrium , which theoretically should be preventable with progestational agents .

CCNU

pulmonary toxicity

Although lung specimens were lacking from these three patients , it is suggested that the pulmonary toxicity of CCNU may be dose-related .

calcitriol

secondary hyperparathyroidism

Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication , potassium loss also should be kept in mind .

DCF

immunosuppression

Although myelosuppression is mild , immunosuppression and superinfection are potential hazards of treatment with DCF .

methyl nitrite

methemoglobinemia

Although other nitrites induce methemoglobinemia , exposure to methyl nitrite during phenylpropanolamine production appears to be a new cause of occupational methemoglobinemia .

praziquantel

inflammation

Although praziquantel administration may have been effective in killing the parasite in both patients , we are concerned about the production of marked inflammation as a result of treatment .

retinoic acid

fatal complication

Although retinoic acid is well tolerated by the majority of patients with this disease , a potentially fatal complication of this kind of treatment has been reported : `` the retinoic acid syndrome `` .

MTX

pulmonary toxicity

Although risk factors for MTX -induced pulmonary toxicity are poorly understood , the presence in 3 out of 5 of our patients of pre-existing lung disease , represented by diffuse interstitial changes on chest X-ray , and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis .

gold-salt

nephropathy

Although the data indicate an immune-complex cause for gold-salt nephropathy , the incident antigen ( or antigens ) and mechanism of action remain unidentified .

penicillamine

PV

Although the essential cause of PV is unclear , its onset has occasionally been associated with drug therapy , in particular penicillamine .

dopamine

coronary vasoconstriction

Although the existence of an acute pericarditis or an acute myocarditis as possible causes of the ST elevation can not be fully ruled out , the sudden onset , prominent magnitude , and brief duration of the ST elevation are perhaps more indicative of an acute ischemic event , possibly related to a transient coronary vasoconstriction induced by the dopamine infusion .

trazodone

movement disorder

Although the movement disorder could not with certainty be attributed to trazodone alone , the drug at least acted as an eliciting agent .

t-PA

cholesterol crystal embolization

Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations ( N Engl J Med 321:1270 , 1989 ) , this is the first reported case of atheroembolic acute renal failure following t-PA therapy .

ampicillin

seizures

Although they had complex medical problems , the high serum concentrations of ampicillin at the time of seizures without their recurrence after discontinuing the antibiotic suggest that the seizures were related to the ampicillin therapy .

methotrexate

nodules

Although they had only a few nodules at diagnosis , the nodules increased in number and size 3 to 4 months after the start of methotrexate therapy in both patients .

G-CSF

leucocytosis

Although this G-CSF -driven leucocytosis was alarming it did not appear to have adversely affected the patient 's prognosis .

bretylium

ventricular arrhythmia

Although transient increases in ectopy after bretylium therapy have been described , presumably due to catecholamine release , the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized .

disulfiram

catatonia

Although useful in the management of chronic alcoholism , disulfiram is being increasingly associated with a wide spectrum of side effects and untoward medical sequelae , which now include catatonia .

Aluminum

Aluminum intoxication

Aluminum intoxication Aluminum intoxication , along with other factors , was considered to be the cause of TC development .

gold

Alveolar-interstitial pneumopathy

Alveolar-interstitial pneumopathy after gold -salts compounds administration , requiring mechanical ventilation .

metronidazole

Amebic abscess of the spleen

Amebic abscess of the spleen complicated by metronidazole -induced neurotoxicity : case report .

Amiodarone

dysthyroidism

Amiodarone -induced dysthyroidism .

Amiodarone

thyrotoxicosis

Amiodarone -induced thyrotoxicosis associated with thyrotropin receptor antibody .

Amiodarone hydrochloride

pulmonary toxicity

Amiodarone hydrochloride , a new antiarrhythmic agent , has been associated with pulmonary toxicity characterized by cough , dyspnea and diffuse pulmonary infiltrates .

Amiodarone

AVT

Amiodarone was the third drug to induce AVT in this patient ; she received 200 mg/day six days per week for six months .

amiodarone

thyrotoxicosis

Among 12 thyrotoxic patients , a patient with arrhythmogenic right ventricular dysplasia , who had been taking amiodarone for 4 years , developed thyrotoxicosis with subacute onset , accompanied by transiently positive thyrotropin ( TSH ) receptor antibody ( TRAb ) , or thyrotropin-binding inhibiting immunoglobulin ( TBII ) .

Amoxapine

cognitive impairment

Amoxapine -induced cognitive impairment in two patients .

Amphotericin B

nephrotoxicity

Amphotericin B nephrotoxicity in humans decreased by salt repletion .

Amphotericin B

cardiac arrest

Amphotericin B overdose in pediatric patients with associated cardiac arrest .

Ampicillin

seizures

Ampicillin -associated seizures .

Ampicillin

electrical decrement

Ampicillin increased the preexisting electrical decrement in three rabbits with experimental autoimmune myasthenia gravis while the drug had no deleterious effects in less affected or normal animals .

Ampicillin

myasthenia gravis

Ampicillin may aggravate clinical and experimental myasthenia gravis .

Levemepromazine

respiratory distress syndrome

An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate ( Levemepromazine ) a phenothiazine antipsychotic drug , was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome .

BCG

osteomyelitis in the left calcaneus

An 8-year-old girl , who had been vaccinated with BCG without subsequent regional reactions , developed osteomyelitis in the left calcaneus 7 months later .

L-asparaginase

acute pancreatitis

An adolescent male developed acute pancreatitis and pseudocyst of the pancreas 16 weeks after cessation of intramuscular L-asparaginase .

PTU

granulocytopenia

An association of granulocytopenia , eosinophilia , skin reaction and hepatitis during propylthiouracil ( PTU ) therapy for thyrotoxicosis in a 47 year old black female is reported .

procainamide hydrochloride

lupus syndrome

An elderly man with procainamide hydrochloride -induced lupus syndrome had a circulating anticoagulant against factor XI and a biologic false-positive ( BFP ) test result for syphilis .

methimazole

choanal atresia

An infant girl with choanal atresia , athelia , minor anomalies , and mild to moderate mental retardation was born to a woman treated for hyperthyroidism throughout pregnancy with methimazole and propranolol .

Bromocryptine

lost vision

An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment .

acetazolamide

severe acidosis

An insulin-dependent diabetic patient with nephropathy developed severe acidosis after treatment with acetazolamide for glaucoma .

Ecstasy

Ecstasy poisoning

An unusual case of Ecstasy poisoning Ecstasy poisoning .

burn injury

psoralens

An unusual cause of burn injury : unsupervised use of drugs that contain psoralens .

prednisone

Anaphylactic reaction

Anaphylactic reaction to oral prednisone : a case report and review of the literature .

dextrose

Anaphylactoid reaction

Anaphylactoid reaction to 50 % solution of dextrose .

methylprednisolone

Anaphylactoid reaction

Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis .

cisplatin

Anaphylactoid reactions

Anaphylactoid reactions with intraperitoneal cisplatin .

zomepirac

Anaphylactoid shock

Anaphylactoid shock , disseminated intravascular coagulation , and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache .

cyclosporine

Anaphylaxis

Anaphylaxis to intravenous cyclosporine and tolerance to oral cyclosporine : case report and review .

desipramine

Anhedonic ejaculation

Anhedonic ejaculation with desipramine .

HAL

significant 32 % -46 % loss of tyrosine hydroxylase ( TH ) immunoreactive neurons

Animals treated with HAL showed a highly significant 32 % -46 % loss of tyrosine hydroxylase ( TH ) immunoreactive neurons in the substantia nigra , and 20 % contraction of the TH stained dendritic arbour .

interferon alfa

Anterior ischemic optic neuropathy

Anterior ischemic optic neuropathy secondary to interferon alfa .

phenol

Anterior spinal artery syndrome

Anterior spinal artery syndrome -- a complication of cervical intrathecal phenol injection .

sulfamethoxazole

colitis

Antibiotic-associated colitis ( pseudomembranous colitis ) developed in four patients with spinal cord injury and taking oral trimethoprim - sulfamethoxazole .

propylthiouracil

Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis

Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy .

methazolamide

Aplastic anemia

Aplastic anemia and agranulocytosis in patients using methazolamide for glaucoma .

morphine

bradypneic

Approximately 15 min after the first administration of nebulised morphine the patient became markedly bradypneic ( respiratory rate : 4-5 bpm ) , hypotensive ( BP 70/40 mmHg ) , and responded only partially to command .

amphotericin B

Arrhythmias

Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them .

phenylephrine

Arterial hypertension

Arterial hypertension associated with topical ocular use of phenylephrine in dogs .

AZ

acute hemorrhagic gastritis

As far as we know , this is the first case report of acute hemorrhagic gastritis associated with AZ intoxication AZ intoxication .

tuberculin

hypersensitivity response

As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline , it was probably caused by restoration of pathogen-specific cellular immunity .

insulin

hypoglycaemia

Assessment of cortisol response was by insulin -induced hypoglycaemia in three cases , by short tetracosactrin test in two , and by low-dose tetracosactrin and 24-hour urinary cortisol/creatinine ratio in one .

Atenolol

memory impairment

Atenolol induced memory impairment : a case report .

methylprednisolone

Atrial fibrillation

Atrial fibrillation following methylprednisolone pulse therapy .

diltiazem

Atrial fibrillation

Atrial fibrillation was induced by diltiazem in two patients and verapamil induced syncope in one patient .

amiodarone

Atrioventricular block

Atrioventricular block complicating amiodarone -induced hypothyroidism in a patient with pre-excitation and rate-dependent bilateral bundle branch block .

theophylline

reaction to the drug became more toxic

Attempts were made to stop and then restart the theophylline therapy at progressively lower doses ; however , with each attempt , the patient 's reaction to the drug became more toxic , with serum theophylline levels ranging between 99.9 and 149.9 micromol/L ( 18 and 27 microg/mL ) .

amiodarone

Atypical ventricular tachycardia

Atypical ventricular tachycardia ( torsade de pointes ) induced by amiodarone : arrhythmia previously induced by quinidine and disopyramide .

Ara-C

herpesvirus infection

Autopsy evidence of herpesvirus infection was found in visceral organs of four leukemic patients who had received large doses of cytarabine ( cytosine arabinoside ; Ara-C ) shortly before their death .

Azathioprine

myelosuppression

Azathioprine -induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis .

Azathioprine

myelosuppression

Azathioprine can cause severe myelosuppression .

Colchicine

adverse effect on wound healing

BACKGROUND : Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation .

Fluoxetine

sexual dysfunction

BACKGROUND : Fluoxetine , a highly specific serotonin reuptake inhibitor , has been reported to cause sexual dysfunction in a minority of patients .

cyclosporine

Hypersensitivity reactions

BACKGROUND : Hypersensitivity reactions to cyclosporine are rare .

MTX

liver damage

BACKGROUND : Methotrexate ( MTX ) may induce liver damage , which in some psoriatics will lead to fibrosis or cirrhosis .

heroin

Ballistic movements

Ballistic movements due to ischemic infarcts after intravenous heroin overdose : report of two cases .

Barbiturate

submassive hepatic necrosis

Barbiturate -induced submassive hepatic necrosis .