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Chlormadinone acetate | withdrawal syndrome | Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer . |
Chlorpropamide | hemolytic anemia | Chlorpropamide -induced hemolytic anemia . |
methimazole | Choanal atresia | Choanal atresia and athelia : methimazole teratogenicity or a new syndrome ? |
clindamycin | Cholestatic liver disease | Cholestatic liver disease with ductopenia ( vanishing bile duct syndrome ) after administration of clindamycin and trimethoprim-sulfamethoxazole . |
tissue-type plasminogen activator | Cholesterol crystal embolization | Cholesterol crystal embolization -associated renal failure after therapy with recombinant tissue-type plasminogen activator . |
Cholestyramine | hyperchloremic metabolic acidosis | Cholestyramine induced hyperchloremic metabolic acidosis . |
tissue plasminogen activator | Choroidal hemorrhage | Choroidal hemorrhage associated with systemic tissue plasminogen activator . |
chlorambucil | Chromosome abnormalities | Chromosome abnormalities after chlorambucil therapy of polycythaemia vera . |
hydrochlorothiazide | Chronic photosensitivity | Chronic photosensitivity associated with hydrochlorothiazide ingestion occurred in four patients . |
Cimetidine | fever | Cimetidine -induced fever . |
Cimetidine | fever | Cimetidine is a rare cause of drug-induced fever . |
procainamide | lupus syndrome | Circulating anticoagulant in the procainamide -induced lupus syndrome . |
gold | neuropathy | Clinical and morphological features of gold neuropathy . |
magnesium sulfate | hypermagnesemia | Clinical signs of hypermagnesemia are an uncommon complication following oral administration of magnesium sulfate . |
disopyramide | fasting hypoglycemia | Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy . |
vinorelbine | SIADH | Clinicians should be aware of the possibility that vinorelbine may cause SIADH and possibly hypokalemia . |
phenolphthalein | TEN | Clinicians should include phenolphthalein in their list of possible causes of drug-induced TEN . |
mefloquine | severe hypoglycaemia | Clinicians who manage cachectic patients , particularly those with protracted diarrhoea and/or receiving anti-malarial drugs including mefloquine , should be aware of the risk of severe hypoglycaemia . |
Clofibrate | myopathy | Clofibrate -induced myopathy in patients with diabetes insipidus . |
Clonidine | bradycardia | Clonidine -induced bradycardia in patients with spinal cord injury . |
cisplatin | Clostridium difficile colitis | Clostridium difficile colitis associated with cisplatin -based chemotherapy in ovarian cancer patients . |
clindamycin phosphate | Clostridium difficile toxin-induced colitis | Clostridium difficile toxin-induced colitis after use of clindamycin phosphate vaginal cream . |
Clozapine | polyserositis | Clozapine induced polyserositis . |
Clozapine | rhabdomyolysis | Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels . |
Co-trimoxazole | red cell aplasia | Co-trimoxazole red cell aplasia in leukaemia . |
nefazodone | interfere with tacrolimus metabolism | Coadministration of antidepressant agents such as nefazodone , or any other drug that inhibits the CYP3A4 isoenzyme subfamily , should be anticipated to interfere with tacrolimus metabolism tacrolimus metabolism . |
cephalosporin | Coagulopathy | Coagulopathy associated with the use of cephalosporin or moxalactam antibiotics in acute and chronic renal failure . |
propranolol | disorientation | Comparable adverse effects , such as disorientation and temporary amnesia , have been reported in patients in the analogous agent , propranolol . |
hydroxychloroquine | nephrosis | Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy . |
methotrexate | Concurrent acute megaloblastic anaemia | Concurrent acute megaloblastic anaemia and pneumonitis : a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis . |
budesonide | Contact dermatitis | Contact dermatitis due to budesonide : report of five cases and review of the Japanese literature . |
lithium | nephrotoxicity | Controversy concerning the nephrotoxicity of lithium is discussed , and recommendations for the evaluation of renal failure during lithium therapy are provided . |
methotrexate | diffuse interstitial pulmonary fibrosis | Conversely , diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms . |
amphotericin B | cardiac arrhythmia | Correction of serum electrolyte imbalance prevents cardiac arrhythmia during amphotericin B administration . |
quinapril | Cough | Cough induced by quinapril with resolution after changing to fosinopril . |
zidovudine | teratogenic | Currently the use of zidovudine is one of the few specific measures available , and as a potentially teratogenic and fetotoxic agent , any decision for its use requires evaluation of the potential for fetal damage . |
methimazole | Cutaneous reactions | Cutaneous reactions to propylthiouracil and methimazole occur in 3 % -5 % of adults . |
Cyclophosphamide | interstitial pneumonitis | Cyclophosphamide can rarely cause interstitial pneumonitis and fibrosis . |
Cyclophosphamide | pneumonitis | Cyclophosphamide pneumonitis . |
Cyclosporin | hirsutism | Cyclosporin side effects included hirsutism , hypertension , increased blood levels of urea and creatinine , and abnormalities in liver function tests . |
Cytarabine | cerebellar syndrome | Cytarabine -induced cerebellar syndrome : case report and literature review . |
D-penicillamine | crescentic glomerulonephritis | D-penicillamine induced crescentic glomerulonephritis : report and review of the literature . |
5-FU | diarrhea | DATA SYNTHESIS : Genetic deficiencies in DPD , the rate-limiting enzyme responsible for 5-FU catabolism , may occur in 3 % or more of patients with cancer putting them at increased risk for unusually severe adverse reactions ( e.g. , diarrhea , stomatitis , mucositis , myelosuppression , neurotoxicity ) to standard doses of 5-FU . |
cisplatin | Anaphylactoid reactions | DISCUSSION : Anaphylactoid reactions have been described previously with cisplatin administration . |
ifosfamide | Central nervous system ( CNS ) toxicity | DISCUSSION : Central nervous system ( CNS ) toxicity has been described with ifosfamide , with most cases reported in the pediatric population . |
foscarnet | Electrolyte disorders | DISCUSSION : Electrolyte disorders associated with foscarnet are reviewed . |
clindamycin | C. difficile toxin in stool | DISCUSSION : No published clinical studies in patients receiving clindamycin vaginal cream for bacterial vaginosis have documented C. difficile toxin in stool samples of patients with diarrhea . |
Phenolphthalein | TEN | DISCUSSION : Phenolphthalein is the active ingredient in several over-the-counter laxative preparations and has only rarely been reported to cause TEN . |
lovastatin | Rhabdomyolysis | DISCUSSION : Rhabdomyolysis is a clinical syndrome resulting from the destruction of skeletal muscle that may progress to renal failure Several drugs have been associated with rhabdomyolysis , including lovastatin , a hydroxymethylglutaryl-coenzyme A reductase inhibitor . |
Danazol | thrombocytopenia | Danazol induced thrombocytopenia . |
Dapsone | Dapsone syndrome | Dapsone syndrome Dapsone syndrome in cutaneous lupus erythematosus . |
alprazolam | Decreased plasma cortisol level | Decreased plasma cortisol level during alprazolam treatment of panic disorder : a case report . |
colchicine | Delay of corneal wound healing | Delay of corneal wound healing in patients treated with colchicine . |
flurbiprofen | Delayed hypersensitivity | Delayed hypersensitivity to flurbiprofen . |
interleukin-2 | neurotoxicity | Delayed neurotoxicity of intraventricular interleukin-2 : a case report . |
L-asparaginase | Delayed pseudocyst of the pancreas | Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase . |
niacin | Dental and gingival pain | Dental and gingival pain as side effects of niacin therapy . |
carbamazepine | Deposits of plasma proteins in the skin | Deposits of plasma proteins in the skin during treatment with carbamazepine and diphenylhydantoin . |
Desipramine | SIADH | Desipramine -associated SIADH in an elderly woman : case report . |
nitrofurantoin | pulmonary side effects | Despite the known pulmonary side effects of nitrofurantoin , there is no report of this toxicity occurring in pregnant patients . |
MTX | extensive skin rash | Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia . |
interferon alfa | thrombocythemia | Development of essential thrombocythemia in a patient treated with interferon alfa and pentostatin for hairy cell leukemia . |
macrophage-colony-stimulating factor | nephrotic syndrome | Development of nephrotic syndrome in a patient with acute myeloblastic leukemia after treatment with macrophage-colony-stimulating factor . |
cyclophosphamide | porphyria cutanea tarda | Development of porphyria cutanea tarda after treatment with cyclophosphamide . |
practolol | sclerosing peritonitis | Diagnosis : practolol induced sclerosing peritonitis . |
5-fluorouracil | severe adverse reactions | Dihydropyrimidine dehydrogenase deficiency : a pharmacogenetic defect causing severe adverse reactions to 5-fluorouracil -based chemotherapy . |
Diphenylhydantoin | acute intermittent porphyria | Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria . |
itraconazole | drug eruption | Discontinuation of the itraconazole caused resolution of the drug eruption . |
Disopyramide | hypoglycemia | Disopyramide ( Norpace ) -induced hypoglycemia . |
Disopyramide | heart block | Disopyramide -induced heart block . |
praziquantel | myositis | Disseminated muscular cysticercosis with myositis induced by praziquantel therapy . |
Disulfiram | encephalopathy | Disulfiram encephalopathy as a cause of the catatonia syndrome . |
cefmenoxime | Disulfiram-like reactions | Disulfiram-like reactions with newer cephalosporins : cefmenoxime . |
acyclovir | increase serum lithium levels | Does acyclovir increase serum lithium levels ? |
Doxorubicin | cardiotoxicity | Doxorubicin cardiotoxicity : possible role of digoxin in its prevention . |
quinacrine hydrochloride | psychosis | Drug-induced psychosis resulted from the administration of quinacrine hydrochloride at a dosage of 100 mg twice daily for the treatment of discoid lupus . |
tolazoline | Duodenal ulceration | Duodenal ulceration : a complication of tolazoline therapy . |
asparaginase | Dural sinus thrombosis | Dural sinus thrombosis developed in two children with acute lymphoblastic leukemia during induction treatment with vincristine sulfate , prednisone , and asparaginase . |
IFN | IDDM | During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully . |
carbamazepine | toxic symptoms | During clarithromycin coadministration , four out of the seven patients developed moderate-to-severe toxic symptoms of carbamazepine , such as drowsiness , dizziness , and ataxia , which resolved within 5 days after clarithromycin discontinuation . |
cisplatin | 100 mg/m2 | During her third cycle , she again received cisplatin 100 mg/m2 over 30 minutes and developed palmar pruritus , urticaria , and edema . |
HDARAC | dysarthria | During the first treatment , dysarthria and ataxia were seen after completion of the patient 's eighth and final dose of HDARAC . |
morphine sulfate | Dyspnea | Dyspnea possibly associated with controlled-release morphine sulfate tablets . |
carbamazepine | Dystonia | Dystonia associated with carbamazepine administration : experience in brain-damaged children . |
chlorambucil | EEG abnormalities | EEG abnormalities were observed in two of the nine children during chlorambucil therapy . |
ritonavir | maculopapular eruption | Early ritonavir -induced maculopapular eruption . |
ibuprofen | Edema | Edema associated with ibuprofen therapy . |
dexamethasone | hypertrophic obstructive cardiomyopathy | Effect of beta-blockade on symptomatic dexamethasone -induced hypertrophic obstructive cardiomyopathy in premature infants : three case reports and literature review . |
nitrate | hypotension | Elderly patients for whom nitrate has been prescribed should be warned of the occurrence of hypotension , leading to unconsciousness . |
procainamide | Electrical proarrhythmia | Electrical proarrhythmia with procainamide : a new ICD-drug interaction . |
amiodarone | syncope | Eleven days after initiation of therapy with amiodarone , the patient experienced syncope and was noted to have recurrent episodes of polymorphous ventricular tachycardia . |
clozapine | Eosinophilia | Eosinophilia caused by clozapine was observed in challenge , preceded by a faster neutrophil production and consecutive decrease ( z = 2.27 , p = 0.01 ) . |
clozapine | Eosinophilia | Eosinophilia has been encountered from 0.2 to 61.7 % in clozapine -treated patients , mostly with a transient course and spontaneous remission . |
methotrexate | Erosion of psoriatic plaques | Erosion of psoriatic plaques : an early sign of methotrexate toxicity methotrexate toxicity . |
methotrexate | Erosion of psoriatic plaques | Erosion of psoriatic plaques after chronic methotrexate administration . |
rifampicin | Erythema multiforme bullosum | Erythema multiforme bullosum due to rifampicin . |
Erythromycin | rhabdomyolysis | Erythromycin is a macrolide antibiotic that may increase the risk of lovastatin -induced rhabdomyolysis . |
omeprazole | Esophageal candidiasis | Esophageal candidiasis following omeprazole therapy : a report of two cases . |
omeprazole | Esophageal candidiasis | Esophageal candidiasis was diagnosed at endoscopy in two patients receiving omeprazole therapy . |
propranolol | Esophageal spasm | Esophageal spasm following propranolol overdose relieved by glucagon . |