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olanzapine | severe akathisia | We report on three patients with acute schizophrenia , who developed severe akathisia during treatment with olanzapine ( 20-25 mg/d ) . |
methotrexate | non-Hodgkin lymphoma | We report one case of non-Hodgkin lymphoma in a patient , with a 30-year history of rheumatoid arthritis , taking low dose methotrexate weekly over a 10-month period . |
methotrexate | leukoencephalopathy | We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by , in the first case intrathecally administered methotrexate and , in the second by intrathecally administered methotrexate and cranial irradiation . |
ketoralac | bilateral sensorineural hearing loss | We report the case of a 20-year-old female with polyarteritis nodosa ( PAN ) who developed bilateral sensorineural hearing loss 25 minutes after receiving 30 mg of intravenous ketoralac . |
clozapine | polyserositis | We report the case of a patient who developed polyserositis ( pericardial effusion , pleural effusion , and pericarditis ) after being started on clozapine , and whose symptoms remitted upon discontinuation of clozapine . |
fludarabine | fatal intravascular autoimmune hemolytic anemia | We report the case of a patient with chronic lymphocytic leukemia ( CLL ) who developed fatal intravascular autoimmune hemolytic anemia ( AIHA ) after fludarabine treatment . |
rifampicin | adrenal failure | We report the case of a patient with the acquired immunodeficiency syndrome treated with rifampicin who had a 'normal ' screening test for adrenal insufficiency , yet had clinical evidence of adrenal failure . |
mirtazapine | intoxication | We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia . |
5-FU | squamous-cell carcinoma | We report the development of squamous-cell carcinoma within a basal-cell epithelioma that was treated with intralesional injections of 5-FU . |
promethazine | coma | We report the first case of a patient in a promethazine -induced coma responding to treatment with flumazenil . |
Cyclosporine A | herpes esophagitis | We report the first case of herpes esophagitis in a renal transplant patient treated with Cyclosporine A while on chronic steroid therapy . |
recombinant tissue-type plasminogen activator | renal failure | We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator ( t-PA ) . |
epinephrine | severe hypertension | We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine , submucosal epinephrine , or both . |
vitamin D | severe hypercalcemia | We report the use of pamidronate for acute , severe hypercalcemia secondary to iatrogenic vitamin D poisoning vitamin D poisoning . |
benzarone | severe hepatotoxicity | We report three cases of severe hepatotoxicity related to benzarone , a benzofuran derivative . |
ddI | fulminant hepatic failure | We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine ( ddI ) . |
captopril | neutropenia | We report two cases of neutropenia following captopril use in cardiac patients with trisomy 21 . |
tamoxifen | acute myeloid leukaemia | We report two cases that developed acute myeloid leukaemia ( AML ) during tamoxifen therapy for breast cancer . |
desipramine | anhedonic ejaculation | We report two patients with anhedonic ejaculation ( ejaculation without orgasm ) associated with initiation of treatment with desipramine . |
d-penicillamine | acute generalized dystonia | We reported 3 patients who developed acute generalized dystonia and akinetic rigid syndrome following an initial therapy with d-penicillamine 125-500 mg daily . |
benzarone | hepatotoxicity | We stress the potential of benzarone to cause hepatotoxicity , which usually resembles severe chronic active hepatitis . |
nicotinic acid | liver disease | We suggest that nicotinic acid was the cause of his liver disease , that this case is of particular note because of the rather short period of therapy before the onset of liver injury and the severity of the hepatic failure , and that the probable increased use of nicotinic acid for serum cholesterol control makes it especially important for physicians and their patients to be alert to the signs of hepatotoxicity . |
nefazodone | inhibits metabolism of tacrolimus | We suspect that nefazodone inhibits metabolism of tacrolimus tacrolimus . |
AZ | destroyed the gastric mucosal barrier | We thus concluded that an excessive dose of AZ had probably destroyed the gastric mucosal barrier or thrombocytopenia due to bone marrow disorder and thus eventually led to the development of hemorrhagic gastritis . |
ACTH | hyperkalemia | We wish to call for cautious approach at time of cessation of prolonged ACTH therapy because of possible unexpected and only partially understood hazardous side effects such as hyperkalemia . |
tamoxifen | endometrial adenocarcinoma of the secretory type | Well-differentiated endometrial adenocarcinoma of the secretory type ( FIGO Grade 1 ) with minimal myometrial invasion occurred in a postmenopausal patient on tamoxifen therapy 5 years after mastectomy for breast carcinoma . |
methotrexate | methotrexate toxicity | Well-known signs of methotrexate toxicity methotrexate toxicity include bone marrow suppression and oral and gastrointestinal ulceration . |
co-trimoxazole | red cell aplasia | When co-trimoxazole was stopped the red cell aplasia resolved . |
acyclovir | serum lithium level had increased | When measured , the serum lithium level had increased lithium level had increased 4-fold during acyclovir therapy . |
amphotericin B | severe side effects | When the disease recurred conventional amphotericin B was used again , but had to be stopped because of severe side effects . |
fludarabine | DAT became positive with anti-IgG and anti-C3d antiglobulins | When the patient was treated again with fludarabine nine months later , the DAT became positive with anti-IgG and anti-C3d antiglobulins after the second course of treatment . |
trazodone | involuntary movements | When the trazodone was reduced , the involuntary movements promptly ceased . |
isoniazid | histamine reaction | When tuberculosis patients on isoniazid eat certain varieties of fish they may develop a histamine reaction . |
desmopressin | vague symptoms | When vague symptoms develop during desmopressin therapy , hyponatremia must be considered as part of the differential diagnosis . |
heparin | thrombocytopenia | While most physicians are aware of heparin -induced thrombocytopenia and skin necrosis , the association of heparin and hyperkalemia is less well recognized . |
albendazole | worsening diarrhea | While undergoing treatment with albendazole , he developed worsening diarrhea with abdominal pain and fever . |
diltiazem | cutaneous vasculitis | Widespread cutaneous vasculitis associated with diltiazem . |
Cyclosporine A | herpes esophagitis | With the increasing use of Cyclosporine A in transplant patients , the incidence of herpes esophagitis may increase . |
desmopressin | hyponatremia | Within 24 hours of fluid restriction and cessation of desmopressin , her symptoms and hyponatremia resolved . |
isoniazid | acute renal failure | Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis , a patient developed acute renal failure . |
pranlukast | anemia | Within 6 months of pranlukast withdrawal , anemia resolved and urinary sediment and renal function normalized . |
desmopressin | hyponatremia | Without other causes for the hyponatremia , she was diagnosed with the syndrome of inappropriate antidiuretic hormone , presumably caused by desmopressin . |
penicillamine | Worsening of neurologic syndrome | Worsening of neurologic syndrome in patients with Wilson 's disease with initial penicillamine therapy . |
cisplatin | progressive sensorineural hearing loss | Young children undergoing cisplatin chemotherapy are known to be at risk for progressive sensorineural hearing loss . |
Zidovudine | birth defects | Zidovudine use in pregnancy : a report on 104 cases and the occurrence of birth defects . |
Ambien | death | Zolpidem ( Ambien ) , a relatively new nonbenzodiazepine sedative-hypnotic , was involved in the death of a 39-year-old obese male who was being treated for depression and insomnia . |
Ambien | death | Zolpidem tissue concentrations in a multiple drug related death involving Ambien . |
lithium carbonate | Creutzfeldt-Jakob like syndrome | a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment . |
lithium | akathisia | k bipolar manic-depressive patient , developed while on lithium prophylaxis , akathisia at therapeutic serum lithium levels and subsequently bucco-linguo-masticatory dyskinesia . |
rifabutin | uveitis | over the past 3 years there have been several reports of uveitis associated with rifabutin therapy . |