Datasets:

rntc

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ncbi_disease_knowledge_0_shots_train

like 0

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: A common human skin tumour is caused by activating mutations in beta-catenin. Useful knowledge : ||| human definition: Members of the species Homo sapiens. ||| skin tumour definition: Tumors or cancer of the SKIN. ||| activating definition: To cause something to start or to stimulate activity. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output:

A common human @@skin tumour## is caused by activating mutations in beta-catenin.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: A common human skin tumour is caused by activating mutations in beta-catenin. Useful knowledge : ||| human definition: Members of the species Homo sapiens. ||| skin tumour definition: Tumors or cancer of the SKIN. ||| activating definition: To cause something to start or to stimulate activity. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output: [/INST] A common human @@skin tumour## is caused by activating mutations in beta-catenin.

A common human @@skin tumour## is caused by activating mutations in beta-catenin.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: WNT signalling orchestrates a number of developmental programs. Useful knowledge : ||| signalling definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] ||| developmental programs definition: The process of formulating, improving, and expanding educational, managerial, or service-oriented work plans (excluding computer program development). ||| Output:

WNT signalling orchestrates a number of developmental programs.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: WNT signalling orchestrates a number of developmental programs. Useful knowledge : ||| signalling definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] ||| developmental programs definition: The process of formulating, improving, and expanding educational, managerial, or service-oriented work plans (excluding computer program development). ||| Output: [/INST] WNT signalling orchestrates a number of developmental programs.

WNT signalling orchestrates a number of developmental programs.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family. Useful knowledge : ||| response definition: Any act or phenomena, or behavior, constituting a reply or reaction of a living organism or its part to some foregoing stimulus or agent. ||| stimulus definition: An environmental event, agent, act, or influence that can be detected by a receptor in the body and will invariably produce a reaction in a living organism, e.g. change in the behavior, functional or trophic reaction. ||| cytoplasmic definition: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990) ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| CTNNB1 definition: This gene is involved in signal transduction and regulation of transcription. ||| stabilized definition: Condition did not change and required not further care to maintain condition ||| downstream definition: None ||| transcriptional activation definition: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes. ||| Output:

In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family. Useful knowledge : ||| response definition: Any act or phenomena, or behavior, constituting a reply or reaction of a living organism or its part to some foregoing stimulus or agent. ||| stimulus definition: An environmental event, agent, act, or influence that can be detected by a receptor in the body and will invariably produce a reaction in a living organism, e.g. change in the behavior, functional or trophic reaction. ||| cytoplasmic definition: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990) ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| CTNNB1 definition: This gene is involved in signal transduction and regulation of transcription. ||| stabilized definition: Condition did not change and required not further care to maintain condition ||| downstream definition: None ||| transcriptional activation definition: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes. ||| Output: [/INST] In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family.

In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: One of the target genes for beta-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to cancer, particularly in the colon. Useful knowledge : ||| target genes definition: A gene proposed to have a primary role in a disease, based upon its known function in other organisms or model systems or based upon its physical proximity to markers linked to a genetic disease. ||| c-MYC definition: None ||| constitutive activation definition: Nuclear receptor subfamily 1 group I member 3 (352 aa, ~40 kDa) is encoded by the human NR1I3 gene. This protein is involved in the regulation of xenobiotic and endobiotic metabolism. ||| WNT pathway definition: A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| colon definition: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON. ||| Output:

One of the target genes for beta-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to @@cancer##, particularly in the colon.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: One of the target genes for beta-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to cancer, particularly in the colon. Useful knowledge : ||| target genes definition: A gene proposed to have a primary role in a disease, based upon its known function in other organisms or model systems or based upon its physical proximity to markers linked to a genetic disease. ||| c-MYC definition: None ||| constitutive activation definition: Nuclear receptor subfamily 1 group I member 3 (352 aa, ~40 kDa) is encoded by the human NR1I3 gene. This protein is involved in the regulation of xenobiotic and endobiotic metabolism. ||| WNT pathway definition: A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| colon definition: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON. ||| Output: [/INST] One of the target genes for beta-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to @@cancer##, particularly in the colon.

One of the target genes for beta-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to @@cancer##, particularly in the colon.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Most colon cancers arise from mutations in the gene encoding adenomatous polyposis coli (APC), a protein required for ubiquitin-mediated degradation of beta-catenin, but a small percentage of colon and some other cancers harbour beta-catenin-stabilizing mutations. Useful knowledge : ||| colon cancers definition: A primary or metastatic malignant neoplasm that affects the colon. Representative examples include carcinoma, lymphoma, and sarcoma. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| gene definition: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. ||| encoding definition: None ||| adenomatous polyposis coli ( definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| ubiquitin-mediated degradation definition: Ubiquitinated Protein Degradation involves the regulated covalent conjugation of one or more ubiquitin residues to one or more sites on a protein that acts as a tag by which the protein-transport machinery ferries the targeted ubiquinated protein to the proteasome for proteolytic destruction. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| colon definition: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON. ||| cancers definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| Output:

Most @@colon cancers## arise from mutations in the gene encoding @@adenomatous polyposis coli## (@@APC##), a protein required for ubiquitin-mediated degradation of beta-catenin, but a small percentage of @@colon and some other cancers## harbour beta-catenin-stabilizing mutations.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Most colon cancers arise from mutations in the gene encoding adenomatous polyposis coli (APC), a protein required for ubiquitin-mediated degradation of beta-catenin, but a small percentage of colon and some other cancers harbour beta-catenin-stabilizing mutations. Useful knowledge : ||| colon cancers definition: A primary or metastatic malignant neoplasm that affects the colon. Representative examples include carcinoma, lymphoma, and sarcoma. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| gene definition: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. ||| encoding definition: None ||| adenomatous polyposis coli ( definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| ubiquitin-mediated degradation definition: Ubiquitinated Protein Degradation involves the regulated covalent conjugation of one or more ubiquitin residues to one or more sites on a protein that acts as a tag by which the protein-transport machinery ferries the targeted ubiquinated protein to the proteasome for proteolytic destruction. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| colon definition: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON. ||| cancers definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| Output: [/INST] Most @@colon cancers## arise from mutations in the gene encoding @@adenomatous polyposis coli## (@@APC##), a protein required for ubiquitin-mediated degradation of beta-catenin, but a small percentage of @@colon and some other cancers## harbour beta-catenin-stabilizing mutations.

Most @@colon cancers## arise from mutations in the gene encoding @@adenomatous polyposis coli## (@@APC##), a protein required for ubiquitin-mediated degradation of beta-catenin, but a small percentage of @@colon and some other cancers## harbour beta-catenin-stabilizing mutations.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Recently, we discovered that transgenic mice expressing an activated beta-catenin are predisposed to developing skin tumours resembling pilomatricomas. Useful knowledge : ||| transgenic mice definition: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. ||| expressing definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. ||| activated definition: To cause something to start or to stimulate activity. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| predisposed definition: None ||| skin tumours definition: Tumors or cancer of the SKIN. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| Output:

Recently, we discovered that transgenic mice expressing an activated beta-catenin are predisposed to developing @@skin tumours## resembling @@pilomatricomas##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Recently, we discovered that transgenic mice expressing an activated beta-catenin are predisposed to developing skin tumours resembling pilomatricomas. Useful knowledge : ||| transgenic mice definition: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. ||| expressing definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. ||| activated definition: To cause something to start or to stimulate activity. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| predisposed definition: None ||| skin tumours definition: Tumors or cancer of the SKIN. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| Output: [/INST] Recently, we discovered that transgenic mice expressing an activated beta-catenin are predisposed to developing @@skin tumours## resembling @@pilomatricomas##.

Recently, we discovered that transgenic mice expressing an activated beta-catenin are predisposed to developing @@skin tumours## resembling @@pilomatricomas##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human pilomatricomas might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations. Useful knowledge : ||| skin definition: None ||| adult definition: A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. ||| mice definition: The common mouse species, Mus musculus. ||| de novo definition: Anew, afresh, or over again from the beginning. ||| hair-follicle morphogenesis definition: The process in which the anatomical structures of the hair follicle are generated and organized. [GOC:ln] ||| human definition: Members of the species Homo sapiens. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| hair matrix cells definition: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound. ||| Output:

Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human @@pilomatricomas## might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human pilomatricomas might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations. Useful knowledge : ||| skin definition: None ||| adult definition: A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. ||| mice definition: The common mouse species, Mus musculus. ||| de novo definition: Anew, afresh, or over again from the beginning. ||| hair-follicle morphogenesis definition: The process in which the anatomical structures of the hair follicle are generated and organized. [GOC:ln] ||| human definition: Members of the species Homo sapiens. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| hair matrix cells definition: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound. ||| Output: [/INST] Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human @@pilomatricomas## might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations.

Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human @@pilomatricomas## might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Here, we explore the cell origin and aetiology of this common human skin tumour. Useful knowledge : ||| cell origin definition: The name of the cell from which the biological specimen was derived. ||| aetiology definition: Used with diseases for causative agents including microorganisms and includes environmental and social factors and personal habits as contributing factors. It includes pathogenesis. ||| human definition: Members of the species Homo sapiens. ||| skin tumour definition: Tumors or cancer of the SKIN. ||| Output:

Here, we explore the cell origin and aetiology of this common human @@skin tumour##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Here, we explore the cell origin and aetiology of this common human skin tumour. Useful knowledge : ||| cell origin definition: The name of the cell from which the biological specimen was derived. ||| aetiology definition: Used with diseases for causative agents including microorganisms and includes environmental and social factors and personal habits as contributing factors. It includes pathogenesis. ||| human definition: Members of the species Homo sapiens. ||| skin tumour definition: Tumors or cancer of the SKIN. ||| Output: [/INST] Here, we explore the cell origin and aetiology of this common human @@skin tumour##.

Here, we explore the cell origin and aetiology of this common human @@skin tumour##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: We found nuclear LEF-1 in the dividing tumour cells, providing biochemical evidence that pilomatricomas are derived from hair matrix cells. Useful knowledge : ||| nuclear definition: Pertaining to the nucleus. ||| LEF-1 definition: Lymphoid enhancer-binding factor 1 (399 aa, ~44 kDa) is encoded by the human LEF1 gene. This protein is involved in Wnt signaling and transcriptional regulation. ||| biochemical definition: Of or relating to biochemistry; involving chemical processes in living organisms. ||| evidence definition: Knowledge on which to base belief. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| hair matrix cells definition: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound. ||| Output:

We found nuclear LEF-1 in the dividing @@tumour## cells, providing biochemical evidence that @@pilomatricomas## are derived from hair matrix cells.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: We found nuclear LEF-1 in the dividing tumour cells, providing biochemical evidence that pilomatricomas are derived from hair matrix cells. Useful knowledge : ||| nuclear definition: Pertaining to the nucleus. ||| LEF-1 definition: Lymphoid enhancer-binding factor 1 (399 aa, ~44 kDa) is encoded by the human LEF1 gene. This protein is involved in Wnt signaling and transcriptional regulation. ||| biochemical definition: Of or relating to biochemistry; involving chemical processes in living organisms. ||| evidence definition: Knowledge on which to base belief. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| hair matrix cells definition: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound. ||| Output: [/INST] We found nuclear LEF-1 in the dividing @@tumour## cells, providing biochemical evidence that @@pilomatricomas## are derived from hair matrix cells.

We found nuclear LEF-1 in the dividing @@tumour## cells, providing biochemical evidence that @@pilomatricomas## are derived from hair matrix cells.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: At least 75% of these tumours possess mutations affecting the amino-terminal segment, normally involved in phosphorylation-dependent, ubiquitin-mediated degradation of the protein. Useful knowledge : ||| tumours definition: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| affecting definition: To be influenced by or changed. ||| amino-terminal segment definition: The amino acid residing in the first position of a protein or peptide. ||| phosphorylation-dependent definition: Binding to a protein upon phosphorylation of the target protein. [PMID:26060076] ||| ubiquitin-mediated degradation definition: Ubiquitinated Protein Degradation involves the regulated covalent conjugation of one or more ubiquitin residues to one or more sites on a protein that acts as a tag by which the protein-transport machinery ferries the targeted ubiquinated protein to the proteasome for proteolytic destruction. ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| Output:

At least 75% of these @@tumours## possess mutations affecting the amino-terminal segment, normally involved in phosphorylation-dependent, ubiquitin-mediated degradation of the protein.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: At least 75% of these tumours possess mutations affecting the amino-terminal segment, normally involved in phosphorylation-dependent, ubiquitin-mediated degradation of the protein. Useful knowledge : ||| tumours definition: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| affecting definition: To be influenced by or changed. ||| amino-terminal segment definition: The amino acid residing in the first position of a protein or peptide. ||| phosphorylation-dependent definition: Binding to a protein upon phosphorylation of the target protein. [PMID:26060076] ||| ubiquitin-mediated degradation definition: Ubiquitinated Protein Degradation involves the regulated covalent conjugation of one or more ubiquitin residues to one or more sites on a protein that acts as a tag by which the protein-transport machinery ferries the targeted ubiquinated protein to the proteasome for proteolytic destruction. ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| Output: [/INST] At least 75% of these @@tumours## possess mutations affecting the amino-terminal segment, normally involved in phosphorylation-dependent, ubiquitin-mediated degradation of the protein.

At least 75% of these @@tumours## possess mutations affecting the amino-terminal segment, normally involved in phosphorylation-dependent, ubiquitin-mediated degradation of the protein.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This percentage of CTNNB1 mutations is greater than in all other human tumours examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans.. Useful knowledge : ||| percentage definition: A unit for expressing a number as a fraction of hundred (on the basis of a rate or proportion per hundred). ||| CTNNB1 definition: This gene is involved in signal transduction and regulation of transcription. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| human tumours definition: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. ||| hair matrix cell definition: Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components. ||| tumorigenesis definition: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. ||| humans definition: Members of the species Homo sapiens. ||| Output:

This percentage of CTNNB1 mutations is greater than in all other human @@tumours## examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans..

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This percentage of CTNNB1 mutations is greater than in all other human tumours examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans.. Useful knowledge : ||| percentage definition: A unit for expressing a number as a fraction of hundred (on the basis of a rate or proportion per hundred). ||| CTNNB1 definition: This gene is involved in signal transduction and regulation of transcription. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| human tumours definition: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. ||| hair matrix cell definition: Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components. ||| tumorigenesis definition: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. ||| humans definition: Members of the species Homo sapiens. ||| Output: [/INST] This percentage of CTNNB1 mutations is greater than in all other human @@tumours## examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans..

This percentage of CTNNB1 mutations is greater than in all other human @@tumours## examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans..

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HFE mutations analysis in 711 hemochromatosis probands: evidence for S65C implication in mild form of hemochromatosis. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| probands definition: None ||| evidence definition: Knowledge on which to base belief. ||| mild form definition: Gentle or temperate in nature or degree. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| Output:

HFE mutations analysis in 711 @@hemochromatosis## probands: evidence for S65C implication in mild form of @@hemochromatosis##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HFE mutations analysis in 711 hemochromatosis probands: evidence for S65C implication in mild form of hemochromatosis. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| probands definition: None ||| evidence definition: Knowledge on which to base belief. ||| mild form definition: Gentle or temperate in nature or degree. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| Output: [/INST] HFE mutations analysis in 711 @@hemochromatosis## probands: evidence for S65C implication in mild form of @@hemochromatosis##.

HFE mutations analysis in 711 @@hemochromatosis## probands: evidence for S65C implication in mild form of @@hemochromatosis##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Hereditary hemochromatosis (HH) is a common autosomal recessive genetic disorder of iron metabolism. Useful knowledge : ||| Hereditary hemochromatosis definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| HH definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| autosomal definition: Any chromosome other than a sex chromosome. [GOC:mah] ||| iron metabolism definition: sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosynthesis) and catabolism of iron; the buildup and breakdown of iron for utilization by the organism. ||| Output:

@@Hereditary hemochromatosis## (@@HH##) is a common @@autosomal recessive genetic disorder## of iron metabolism.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Hereditary hemochromatosis (HH) is a common autosomal recessive genetic disorder of iron metabolism. Useful knowledge : ||| Hereditary hemochromatosis definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| HH definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| autosomal definition: Any chromosome other than a sex chromosome. [GOC:mah] ||| iron metabolism definition: sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosynthesis) and catabolism of iron; the buildup and breakdown of iron for utilization by the organism. ||| Output: [/INST] @@Hereditary hemochromatosis## (@@HH##) is a common @@autosomal recessive genetic disorder## of iron metabolism.

@@Hereditary hemochromatosis## (@@HH##) is a common @@autosomal recessive genetic disorder## of iron metabolism.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The HFE candidate gene encoding an HLA class I-like protein involved in HH was identified in 1996. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| encoding definition: None ||| HH definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| identified definition: The procedure of having an identity established. ||| Output:

The HFE candidate gene encoding an HLA class I-like protein involved in @@HH## was identified in 1996.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The HFE candidate gene encoding an HLA class I-like protein involved in HH was identified in 1996. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| encoding definition: None ||| HH definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| identified definition: The procedure of having an identity established. ||| Output: [/INST] The HFE candidate gene encoding an HLA class I-like protein involved in @@HH## was identified in 1996.

The HFE candidate gene encoding an HLA class I-like protein involved in @@HH## was identified in 1996.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Two missense mutations have been described C282Y, accounting for 80% to 90% of HH chromosomes, and H63D, which is associated with a milder form of the disease representing 40% to 70% of non-C282Y HH chromosomes. Useful knowledge : ||| missense mutations definition: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed) ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| associated with definition: Joined in some kind of relationship. ||| disease definition: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| Output:

Two missense mutations have been described C282Y, accounting for 80% to 90% of @@HH## chromosomes, and H63D, which is associated with a milder form of the disease representing 40% to 70% of non-C282Y @@HH## chromosomes.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Two missense mutations have been described C282Y, accounting for 80% to 90% of HH chromosomes, and H63D, which is associated with a milder form of the disease representing 40% to 70% of non-C282Y HH chromosomes. Useful knowledge : ||| missense mutations definition: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed) ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| associated with definition: Joined in some kind of relationship. ||| disease definition: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| Output: [/INST] Two missense mutations have been described C282Y, accounting for 80% to 90% of @@HH## chromosomes, and H63D, which is associated with a milder form of the disease representing 40% to 70% of non-C282Y @@HH## chromosomes.

Two missense mutations have been described C282Y, accounting for 80% to 90% of @@HH## chromosomes, and H63D, which is associated with a milder form of the disease representing 40% to 70% of non-C282Y @@HH## chromosomes.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: We report here on the analysis of C282Y, H63D, and the 193A-- > T substitution leading to the S65C missense substitution in a large series of probands and controls. Useful knowledge : ||| report definition: Detailed account or statement or formal record of the proceedings of a meeting or session. May also document status or progress of an activity or research project. ||| analysis definition: None ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| missense definition: None ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| probands definition: None ||| controls definition: The containment, regulation, or restraint of costs. Costs are said to be contained when the value of resources committed to an activity is not considered excessive. This determination is frequently subjective and dependent upon the specific geographic area of the activity being measured. (From Dictionary of Health Services Management, 2d ed) ||| Output:

We report here on the analysis of C282Y, H63D, and the 193A-- > T substitution leading to the S65C missense substitution in a large series of probands and controls.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: We report here on the analysis of C282Y, H63D, and the 193A-- > T substitution leading to the S65C missense substitution in a large series of probands and controls. Useful knowledge : ||| report definition: Detailed account or statement or formal record of the proceedings of a meeting or session. May also document status or progress of an activity or research project. ||| analysis definition: None ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| missense definition: None ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| probands definition: None ||| controls definition: The containment, regulation, or restraint of costs. Costs are said to be contained when the value of resources committed to an activity is not considered excessive. This determination is frequently subjective and dependent upon the specific geographic area of the activity being measured. (From Dictionary of Health Services Management, 2d ed) ||| Output: [/INST] We report here on the analysis of C282Y, H63D, and the 193A-- > T substitution leading to the S65C missense substitution in a large series of probands and controls.

We report here on the analysis of C282Y, H63D, and the 193A-- > T substitution leading to the S65C missense substitution in a large series of probands and controls.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The results confirm that the C282Y substitution was the main mutation involved in hemochromatosis, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the HH chromosomes that did not carry the C282Y mutation. Useful knowledge : ||| results definition: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition. ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| carrier chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output:

The results confirm that the C282Y substitution was the main mutation involved in @@hemochromatosis##, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the @@HH## chromosomes that did not carry the C282Y mutation.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The results confirm that the C282Y substitution was the main mutation involved in hemochromatosis, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the HH chromosomes that did not carry the C282Y mutation. Useful knowledge : ||| results definition: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition. ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| carrier chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output: [/INST] The results confirm that the C282Y substitution was the main mutation involved in @@hemochromatosis##, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the @@HH## chromosomes that did not carry the C282Y mutation.

The results confirm that the C282Y substitution was the main mutation involved in @@hemochromatosis##, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the @@HH## chromosomes that did not carry the C282Y mutation.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In addition, our screening showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation. Useful knowledge : ||| screening definition: Procedures performed on people to identify those who have NEOPLASMS or PRENEOPLASTIC CONDITIONS. ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| probands definition: None ||| chromosome definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| assigned definition: An allotting or an appointment to a particular person or use, or for a particular time or object. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output:

In addition, our screening showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In addition, our screening showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation. Useful knowledge : ||| screening definition: Procedures performed on people to identify those who have NEOPLASMS or PRENEOPLASTIC CONDITIONS. ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| probands definition: None ||| chromosome definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| assigned definition: An allotting or an appointment to a particular person or use, or for a particular time or object. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output: [/INST] In addition, our screening showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation.

In addition, our screening showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This substitution accounted for 7. Useful knowledge : ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| Output:

This substitution accounted for 7.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This substitution accounted for 7. Useful knowledge : ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| Output: [/INST] This substitution accounted for 7.

This substitution accounted for 7.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 8% of HH chromosomes that were neither C282Y nor H63D. Useful knowledge : ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| Output:

8% of @@HH## chromosomes that were neither C282Y nor H63D.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 8% of HH chromosomes that were neither C282Y nor H63D. Useful knowledge : ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| Output: [/INST] 8% of @@HH## chromosomes that were neither C282Y nor H63D.

8% of @@HH## chromosomes that were neither C282Y nor H63D.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This enrichment of S65C among HH chromosomes suggests that the S65C substitution is associated with the mild form of hemochromatosis. Useful knowledge : ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| associated with definition: Joined in some kind of relationship. ||| mild form definition: Gentle or temperate in nature or degree. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| Output:

This enrichment of S65C among @@HH## chromosomes suggests that the S65C substitution is associated with the mild form of @@hemochromatosis##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This enrichment of S65C among HH chromosomes suggests that the S65C substitution is associated with the mild form of hemochromatosis. Useful knowledge : ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| associated with definition: Joined in some kind of relationship. ||| mild form definition: Gentle or temperate in nature or degree. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| Output: [/INST] This enrichment of S65C among @@HH## chromosomes suggests that the S65C substitution is associated with the mild form of @@hemochromatosis##.

This enrichment of S65C among @@HH## chromosomes suggests that the S65C substitution is associated with the mild form of @@hemochromatosis##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Germline BRCA1 alterations in a population-based series of ovarian cancer cases. Useful knowledge : ||| Germline definition: None ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| Output:

Germline BRCA1 alterations in a population-based series of @@ovarian cancer## cases.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Germline BRCA1 alterations in a population-based series of ovarian cancer cases. Useful knowledge : ||| Germline definition: None ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| Output: [/INST] Germline BRCA1 alterations in a population-based series of @@ovarian cancer## cases.

Germline BRCA1 alterations in a population-based series of @@ovarian cancer## cases.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The objective of this study was to provide more accurate frequency estimates of breast cancer susceptibility gene 1 (BRCA1) germline alterations in the ovarian cancer population. Useful knowledge : ||| objective definition: The end-result or objective, which may be specified or required in advance. ||| study definition: A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. ||| accurate definition: The quality of nearness to the truth or the true value. ||| frequency definition: None ||| estimates definition: To calculate approximately. ||| breast cancer definition: A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males. ||| susceptibility gene 1 definition: Mutated forms of genes which encode proteins that are essential for the control and maintenance of normal cellular processes. Inherited or somatic mutations in the wild-type form of these genes alters control of their expression, resulting in a change in control of the cell cycle. Individuals who harbor cancer-predisposing genes require fewer somatic mutations for transformation of a particular cell, thereby predisposing them to the development of cancer. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| germline alterations definition: Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| population definition: The total number of individuals inhabiting a particular region or area. ||| Output:

The objective of this study was to provide more accurate frequency estimates of @@breast cancer## susceptibility gene 1 (BRCA1) germline alterations in the @@ovarian cancer## population.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The objective of this study was to provide more accurate frequency estimates of breast cancer susceptibility gene 1 (BRCA1) germline alterations in the ovarian cancer population. Useful knowledge : ||| objective definition: The end-result or objective, which may be specified or required in advance. ||| study definition: A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. ||| accurate definition: The quality of nearness to the truth or the true value. ||| frequency definition: None ||| estimates definition: To calculate approximately. ||| breast cancer definition: A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males. ||| susceptibility gene 1 definition: Mutated forms of genes which encode proteins that are essential for the control and maintenance of normal cellular processes. Inherited or somatic mutations in the wild-type form of these genes alters control of their expression, resulting in a change in control of the cell cycle. Individuals who harbor cancer-predisposing genes require fewer somatic mutations for transformation of a particular cell, thereby predisposing them to the development of cancer. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| germline alterations definition: Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| population definition: The total number of individuals inhabiting a particular region or area. ||| Output: [/INST] The objective of this study was to provide more accurate frequency estimates of @@breast cancer## susceptibility gene 1 (BRCA1) germline alterations in the @@ovarian cancer## population.

The objective of this study was to provide more accurate frequency estimates of @@breast cancer## susceptibility gene 1 (BRCA1) germline alterations in the @@ovarian cancer## population.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: To achieve this, we determined the prevalence of BRCA1 alterations in a population-based series of consecutive ovarian cancer cases. Useful knowledge : ||| prevalence definition: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| consecutive definition: In regular succession without gaps. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| Output:

To achieve this, we determined the prevalence of BRCA1 alterations in a population-based series of consecutive @@ovarian cancer## cases.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: To achieve this, we determined the prevalence of BRCA1 alterations in a population-based series of consecutive ovarian cancer cases. Useful knowledge : ||| prevalence definition: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| consecutive definition: In regular succession without gaps. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| Output: [/INST] To achieve this, we determined the prevalence of BRCA1 alterations in a population-based series of consecutive @@ovarian cancer## cases.

To achieve this, we determined the prevalence of BRCA1 alterations in a population-based series of consecutive @@ovarian cancer## cases.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This is the first population-based ovarian cancer study reporting BRCA1 alterations derived from a comprehensive screen of the entire coding region. Useful knowledge : ||| study definition: A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| comprehensive definition: Broad in scope; including all or everything. ||| screen definition: An electronic device designed as a display or a physical device designed to be a protective meshwork. ||| coding region definition: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR). ||| Output:

This is the first population-based @@ovarian cancer## study reporting BRCA1 alterations derived from a comprehensive screen of the entire coding region.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This is the first population-based ovarian cancer study reporting BRCA1 alterations derived from a comprehensive screen of the entire coding region. Useful knowledge : ||| study definition: A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| comprehensive definition: Broad in scope; including all or everything. ||| screen definition: An electronic device designed as a display or a physical device designed to be a protective meshwork. ||| coding region definition: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR). ||| Output: [/INST] This is the first population-based @@ovarian cancer## study reporting BRCA1 alterations derived from a comprehensive screen of the entire coding region.

This is the first population-based @@ovarian cancer## study reporting BRCA1 alterations derived from a comprehensive screen of the entire coding region.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: One hundred and seven ovarian cancer cases were analyzed for BRCA1 alterations using the RNase mismatch cleavage assay followed by direct sequencing. Useful knowledge : ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| analyzed definition: Examination and interpretation; the process of identifying an issue to be understood and addressed, modelling the issue, investigating the model results, interpreting the results, and possibly making a recommendation. The concept also refers to the examination and study of a whole in terms of the parts composing it. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| RNase definition: A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-. ||| direct sequencing definition: A technique used to identify the sequence of individual nucleobases in a single strand of DNA fragment template, which can be a plasmid insert, genomic DNA or a PCR product. In addition, direct sequencing of genomic DNA or PCR products does not require sub-cloning of the gene of interest into a vector. ||| Output:

One hundred and seven @@ovarian cancer## cases were analyzed for BRCA1 alterations using the RNase mismatch cleavage assay followed by direct sequencing.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: One hundred and seven ovarian cancer cases were analyzed for BRCA1 alterations using the RNase mismatch cleavage assay followed by direct sequencing. Useful knowledge : ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| analyzed definition: Examination and interpretation; the process of identifying an issue to be understood and addressed, modelling the issue, investigating the model results, interpreting the results, and possibly making a recommendation. The concept also refers to the examination and study of a whole in terms of the parts composing it. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| RNase definition: A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-. ||| direct sequencing definition: A technique used to identify the sequence of individual nucleobases in a single strand of DNA fragment template, which can be a plasmid insert, genomic DNA or a PCR product. In addition, direct sequencing of genomic DNA or PCR products does not require sub-cloning of the gene of interest into a vector. ||| Output: [/INST] One hundred and seven @@ovarian cancer## cases were analyzed for BRCA1 alterations using the RNase mismatch cleavage assay followed by direct sequencing.

One hundred and seven @@ovarian cancer## cases were analyzed for BRCA1 alterations using the RNase mismatch cleavage assay followed by direct sequencing.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Two truncating mutations, 962del4 and 3600del11, were identified. Useful knowledge : ||| truncating definition: Translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| identified definition: The procedure of having an identity established. ||| Output:

Two truncating mutations, 962del4 and 3600del11, were identified.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Two truncating mutations, 962del4 and 3600del11, were identified. Useful knowledge : ||| truncating definition: Translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| identified definition: The procedure of having an identity established. ||| Output: [/INST] Two truncating mutations, 962del4 and 3600del11, were identified.

Two truncating mutations, 962del4 and 3600del11, were identified.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Both patients had a family history of breast or ovarian cancer. Useful knowledge : ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| family history of definition: A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. ||| breast definition: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| Output:

Both patients had a family history of @@breast or ovarian cancer##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Both patients had a family history of breast or ovarian cancer. Useful knowledge : ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| family history of definition: A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. ||| breast definition: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| Output: [/INST] Both patients had a family history of @@breast or ovarian cancer##.

Both patients had a family history of @@breast or ovarian cancer##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Several novel as well as previously reported uncharacterized variants were also identified, some of which were associated with a family history of cancer. Useful knowledge : ||| uncharacterized definition: The act of describing distinctive characteristics or essential features. ||| variants definition: An alteration or difference from a norm or standard. ||| identified definition: The procedure of having an identity established. ||| associated with definition: Joined in some kind of relationship. ||| family history of cancer definition: A record of a patient's medical background regarding the cancer and cancer-related problems of blood relatives. ||| Output:

Several novel as well as previously reported uncharacterized variants were also identified, some of which were associated with a family history of @@cancer##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Several novel as well as previously reported uncharacterized variants were also identified, some of which were associated with a family history of cancer. Useful knowledge : ||| uncharacterized definition: The act of describing distinctive characteristics or essential features. ||| variants definition: An alteration or difference from a norm or standard. ||| identified definition: The procedure of having an identity established. ||| associated with definition: Joined in some kind of relationship. ||| family history of cancer definition: A record of a patient's medical background regarding the cancer and cancer-related problems of blood relatives. ||| Output: [/INST] Several novel as well as previously reported uncharacterized variants were also identified, some of which were associated with a family history of @@cancer##.

Several novel as well as previously reported uncharacterized variants were also identified, some of which were associated with a family history of @@cancer##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The frequency distribution of common polymorphisms was determined in the 91 Caucasian cancer cases in this series and 24 sister controls using allele-specific amplification. Useful knowledge : ||| frequency definition: None ||| distribution definition: The placement, arrangement of instance of entities within a space. ||| polymorphisms definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| Caucasian definition: A group distinguished by classification according to physical features. This group, also called Europoid, centers around the Mediterranean Sea but includes other parts of Europe. (from Winick: Dictionary of Anthropology, 1972; American Heritage Dictionary, 2d College ed) ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| cases definition: None ||| series definition: A group or succession of objects, substances, or events arranged in regular order in space or time, connected by a like relation, or forming a kind of chain. ||| sister controls definition: The containment, regulation, or restraint of costs. Costs are said to be contained when the value of resources committed to an activity is not considered excessive. This determination is frequently subjective and dependent upon the specific geographic area of the activity being measured. (From Dictionary of Health Services Management, 2d ed) ||| Output:

The frequency distribution of common polymorphisms was determined in the 91 Caucasian @@cancer## cases in this series and 24 sister controls using allele-specific amplification.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The frequency distribution of common polymorphisms was determined in the 91 Caucasian cancer cases in this series and 24 sister controls using allele-specific amplification. Useful knowledge : ||| frequency definition: None ||| distribution definition: The placement, arrangement of instance of entities within a space. ||| polymorphisms definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| Caucasian definition: A group distinguished by classification according to physical features. This group, also called Europoid, centers around the Mediterranean Sea but includes other parts of Europe. (from Winick: Dictionary of Anthropology, 1972; American Heritage Dictionary, 2d College ed) ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| cases definition: None ||| series definition: A group or succession of objects, substances, or events arranged in regular order in space or time, connected by a like relation, or forming a kind of chain. ||| sister controls definition: The containment, regulation, or restraint of costs. Costs are said to be contained when the value of resources committed to an activity is not considered excessive. This determination is frequently subjective and dependent upon the specific geographic area of the activity being measured. (From Dictionary of Health Services Management, 2d ed) ||| Output: [/INST] The frequency distribution of common polymorphisms was determined in the 91 Caucasian @@cancer## cases in this series and 24 sister controls using allele-specific amplification.

The frequency distribution of common polymorphisms was determined in the 91 Caucasian @@cancer## cases in this series and 24 sister controls using allele-specific amplification.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The rare form of the Q356R polymorphism was significantly (P = 0. Useful knowledge : ||| rare definition: Not occurring regularly or at short intervals. ||| polymorphism definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| Output:

The rare form of the Q356R polymorphism was significantly (P = 0.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The rare form of the Q356R polymorphism was significantly (P = 0. Useful knowledge : ||| rare definition: Not occurring regularly or at short intervals. ||| polymorphism definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| Output: [/INST] The rare form of the Q356R polymorphism was significantly (P = 0.

The rare form of the Q356R polymorphism was significantly (P = 0.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 03) associated with a family history of ovarian cancer, suggesting that this polymorphism may influence ovarian cancer risk. Useful knowledge : ||| associated with definition: Joined in some kind of relationship. ||| family history of definition: A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| polymorphism definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| influence definition: The power to have an effect on people, things, or events. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| risk definition: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome. ||| Output:

03) associated with a family history of @@ovarian cancer##, suggesting that this polymorphism may influence @@ovarian cancer## risk.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 03) associated with a family history of ovarian cancer, suggesting that this polymorphism may influence ovarian cancer risk. Useful knowledge : ||| associated with definition: Joined in some kind of relationship. ||| family history of definition: A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| polymorphism definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| influence definition: The power to have an effect on people, things, or events. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| risk definition: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome. ||| Output: [/INST] 03) associated with a family history of @@ovarian cancer##, suggesting that this polymorphism may influence @@ovarian cancer## risk.

03) associated with a family history of @@ovarian cancer##, suggesting that this polymorphism may influence @@ovarian cancer## risk.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In summary, our data suggest a role for some uncharacterized variants and rare forms of polymorphisms in determining ovarian cancer risk, and highlight the necessity to screen for missense alterations as well as truncating mutations in this population. Useful knowledge : ||| data definition: A collection or single item of factual information, derived from measurement or research, from which conclusions may be drawn. ||| uncharacterized definition: The act of describing distinctive characteristics or essential features. ||| variants definition: An alteration or difference from a norm or standard. ||| polymorphisms definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| risk definition: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome. ||| missense definition: None ||| alterations definition: The act or process of modifying something. ||| truncating definition: Translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| population definition: The total number of individuals inhabiting a particular region or area. ||| Output:

In summary, our data suggest a role for some uncharacterized variants and rare forms of polymorphisms in determining @@ovarian cancer## risk, and highlight the necessity to screen for missense alterations as well as truncating mutations in this population.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In summary, our data suggest a role for some uncharacterized variants and rare forms of polymorphisms in determining ovarian cancer risk, and highlight the necessity to screen for missense alterations as well as truncating mutations in this population. Useful knowledge : ||| data definition: A collection or single item of factual information, derived from measurement or research, from which conclusions may be drawn. ||| uncharacterized definition: The act of describing distinctive characteristics or essential features. ||| variants definition: An alteration or difference from a norm or standard. ||| polymorphisms definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| risk definition: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome. ||| missense definition: None ||| alterations definition: The act or process of modifying something. ||| truncating definition: Translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| population definition: The total number of individuals inhabiting a particular region or area. ||| Output: [/INST] In summary, our data suggest a role for some uncharacterized variants and rare forms of polymorphisms in determining @@ovarian cancer## risk, and highlight the necessity to screen for missense alterations as well as truncating mutations in this population.

In summary, our data suggest a role for some uncharacterized variants and rare forms of polymorphisms in determining @@ovarian cancer## risk, and highlight the necessity to screen for missense alterations as well as truncating mutations in this population.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Useful knowledge : ||| Identification definition: A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| homologue definition: A gene from one species which corresponds to a gene in another species and that is related via a common ancestral species. These genes retain a similar sequence and function. ||| adenomatous polyposis coli definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| tumour suppressor definition: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible. ||| Output:

Identification of APC2, a homologue of the @@adenomatous polyposis coli tumour## suppressor.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Useful knowledge : ||| Identification definition: A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| homologue definition: A gene from one species which corresponds to a gene in another species and that is related via a common ancestral species. These genes retain a similar sequence and function. ||| adenomatous polyposis coli definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| tumour suppressor definition: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible. ||| Output: [/INST] Identification of APC2, a homologue of the @@adenomatous polyposis coli tumour## suppressor.

Identification of APC2, a homologue of the @@adenomatous polyposis coli tumour## suppressor.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The adenomatous polyposis coli (APC) tumour-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin. Useful knowledge : ||| adenomatous polyposis coli (APC) definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| tumour-suppressor protein definition: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development. ||| Wnt signalling pathway definition: A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. ||| complex definition: Hard, involved or complicated, elaborate, having many parts. ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output:

The @@adenomatous polyposis coli (APC) tumour##-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The adenomatous polyposis coli (APC) tumour-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin. Useful knowledge : ||| adenomatous polyposis coli (APC) definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| tumour-suppressor protein definition: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development. ||| Wnt signalling pathway definition: A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. ||| complex definition: Hard, involved or complicated, elaborate, having many parts. ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output: [/INST] The @@adenomatous polyposis coli (APC) tumour##-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin.

The @@adenomatous polyposis coli (APC) tumour##-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Complex formation induces the rapid degradation of betacatenin. Useful knowledge : ||| Complex formation definition: The aggregation, arrangement and bonding together of a set of components to form a TORC1 complex. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218] ||| induces definition: The act of bringing about something. ||| degradation definition: None ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output:

Complex formation induces the rapid degradation of betacatenin.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Complex formation induces the rapid degradation of betacatenin. Useful knowledge : ||| Complex formation definition: The aggregation, arrangement and bonding together of a set of components to form a TORC1 complex. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218] ||| induces definition: The act of bringing about something. ||| degradation definition: None ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output: [/INST] Complex formation induces the rapid degradation of betacatenin.

Complex formation induces the rapid degradation of betacatenin.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In colon carcinoma cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]). Useful knowledge : ||| colon carcinoma definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. ||| cells definition: The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary. ||| loss definition: A gradual decline in amount or activity. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| accumulation definition: A state characterized by the gradual increase in entities or substances. ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| nucleus definition: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| binds definition: The action of attracting something and forming a bond with it. ||| activates definition: To cause something to start or to stimulate activity. ||| Tcf-4 transcription factor definition: A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder. ||| reviewed definition: An article or book published after examination of published material on a subject. It may be comprehensive to various degrees and the time range of material scrutinized may be broad or narrow, but the reviews most often desired are reviews of the current literature. The textual material examined may be equally broad and can encompass, in medicine specifically, clinical material as well as experimental research or case reports. State-of-the-art reviews tend to address more current matters. A review of the literature must be differentiated from HISTORICAL ARTICLE on the same subject, but a review of historical literature is also within the scope of this publication type. ||| Output:

In @@colon carcinoma## cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]).

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In colon carcinoma cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]). Useful knowledge : ||| colon carcinoma definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. ||| cells definition: The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary. ||| loss definition: A gradual decline in amount or activity. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| accumulation definition: A state characterized by the gradual increase in entities or substances. ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| nucleus definition: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| binds definition: The action of attracting something and forming a bond with it. ||| activates definition: To cause something to start or to stimulate activity. ||| Tcf-4 transcription factor definition: A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder. ||| reviewed definition: An article or book published after examination of published material on a subject. It may be comprehensive to various degrees and the time range of material scrutinized may be broad or narrow, but the reviews most often desired are reviews of the current literature. The textual material examined may be equally broad and can encompass, in medicine specifically, clinical material as well as experimental research or case reports. State-of-the-art reviews tend to address more current matters. A review of the literature must be differentiated from HISTORICAL ARTICLE on the same subject, but a review of historical literature is also within the scope of this publication type. ||| Output: [/INST] In @@colon carcinoma## cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]).

In @@colon carcinoma## cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]).

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Here, we report the identification and genomic structure of APC homologues. Useful knowledge : ||| identification definition: A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others. ||| genomic structure definition: The structural elements that comprise a gene or transcription unit. Gene structures include the transcription initiation site, the protein coding sequences, intervening sequences, and the transcription termination or polyadenylation sites as well as the regulatory elements (enhancers, silencers, and the promoter) that lie outside the boundaries of the transcribed unit. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| homologues definition: A gene from one species which corresponds to a gene in another species and that is related via a common ancestral species. These genes retain a similar sequence and function. ||| Output:

Here, we report the identification and genomic structure of APC homologues.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Here, we report the identification and genomic structure of APC homologues. Useful knowledge : ||| identification definition: A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others. ||| genomic structure definition: The structural elements that comprise a gene or transcription unit. Gene structures include the transcription initiation site, the protein coding sequences, intervening sequences, and the transcription termination or polyadenylation sites as well as the regulatory elements (enhancers, silencers, and the promoter) that lie outside the boundaries of the transcribed unit. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| homologues definition: A gene from one species which corresponds to a gene in another species and that is related via a common ancestral species. These genes retain a similar sequence and function. ||| Output: [/INST] Here, we report the identification and genomic structure of APC homologues.

Here, we report the identification and genomic structure of APC homologues.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin. Useful knowledge : ||| Mammalian definition: Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| domain structure definition: The components and their relationship and manner of arrangement in constituting a whole. ||| analyzed definition: Examination and interpretation; the process of identifying an issue to be understood and addressed, modelling the issue, investigating the model results, interpreting the results, and possibly making a recommendation. The concept also refers to the examination and study of a whole in terms of the parts composing it. ||| SAMP definition: None ||| binding definition: The action of attracting something and forming a bond with it. ||| conductin definition: This gene is involved in signal transduction and plays a role in development. ||| Output:

Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin. Useful knowledge : ||| Mammalian definition: Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| domain structure definition: The components and their relationship and manner of arrangement in constituting a whole. ||| analyzed definition: Examination and interpretation; the process of identifying an issue to be understood and addressed, modelling the issue, investigating the model results, interpreting the results, and possibly making a recommendation. The concept also refers to the examination and study of a whole in terms of the parts composing it. ||| SAMP definition: None ||| binding definition: The action of attracting something and forming a bond with it. ||| conductin definition: This gene is involved in signal transduction and plays a role in development. ||| Output: [/INST] Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin.

Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- colon carcinoma cells. Useful knowledge : ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| regulates definition: A rule or order issued by an authority stating what may or may not be done or how something must be done. ||| formation definition: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. [GOC:curators, ISBN:0198547684] ||| active definition: Exerting influence or producing an effect. ||| betacatenin-Tcf definition: A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974] ||| complexes definition: A molecular entity formed by loose association involving two or more component molecular entities. The bonding between the components is normally weaker than in a covalent bond. ||| transient transcriptional activation assays definition: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| colon carcinoma definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. ||| cells definition: The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary. ||| Output:

Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- @@colon carcinoma## cells.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- colon carcinoma cells. Useful knowledge : ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| regulates definition: A rule or order issued by an authority stating what may or may not be done or how something must be done. ||| formation definition: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. [GOC:curators, ISBN:0198547684] ||| active definition: Exerting influence or producing an effect. ||| betacatenin-Tcf definition: A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974] ||| complexes definition: A molecular entity formed by loose association involving two or more component molecular entities. The bonding between the components is normally weaker than in a covalent bond. ||| transient transcriptional activation assays definition: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| colon carcinoma definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. ||| cells definition: The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary. ||| Output: [/INST] Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- @@colon carcinoma## cells.

Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- @@colon carcinoma## cells.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Human APC2 maps to chromosome 19p13. Useful knowledge : ||| Human definition: Members of the species Homo sapiens. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| maps definition: A usually 2-dimensional diagrammatic representation of an object or area. ||| chromosome 19p13 definition: A chromosome band present on 19p ||| Output:

Human APC2 maps to chromosome 19p13.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Human APC2 maps to chromosome 19p13. Useful knowledge : ||| Human definition: Members of the species Homo sapiens. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| maps definition: A usually 2-dimensional diagrammatic representation of an object or area. ||| chromosome 19p13 definition: A chromosome band present on 19p ||| Output: [/INST] Human APC2 maps to chromosome 19p13.

Human APC2 maps to chromosome 19p13.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 3. Useful knowledge : ||| Output:

3.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 3. Useful knowledge : ||| Output: [/INST] 3.

3.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: APC and APC2 may therefore have comparable functions in development and cancer. Useful knowledge : ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| functions definition: The normal action performed by a structure or device. ||| development definition: None ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| Output:

APC and APC2 may therefore have comparable functions in development and @@cancer##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: APC and APC2 may therefore have comparable functions in development and cancer. Useful knowledge : ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| functions definition: The normal action performed by a structure or device. ||| development definition: None ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| Output: [/INST] APC and APC2 may therefore have comparable functions in development and @@cancer##.

APC and APC2 may therefore have comparable functions in development and @@cancer##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Familial deficiency of the seventh component of complement associated with recurrent bacteremic infections due to Neisseria. Useful knowledge : ||| Familial deficiency definition: Familial LCAT (lecithin-cholesterol acyltransferase) deficiency (FLD) is a form of lecithin-cholesterol acyltransferase deficiency (LCAT; see this term) characterized clinically by corneal opacities, hemolytic anemia, and renal failure, and biochemically by severely decreased HDL cholesterol and complete deficiency of the LCAT enzyme. ||| complement definition: The complement system is a complex system of serum proteins that interact in a cascade. Many of the early components are serine proteases that activate each other sequentially. This complement system consists of three separate activation triggers: (1) Ab binding to a cell surface, (2) formation of immune complexes, and (3) a carbohydrate component of a microbe's cell membrane. Along with this triggers, there are also two sets of mechanisms. Both of these mechanisms, classical pathway and alternative or properdin pathway, make MAC (Membrane Attack Complex), which can lyse and destroy the cell. ||| associated with definition: Joined in some kind of relationship. ||| recurrent definition: Applied to a sign, symptom, or other manifestation that occurs multiple times at usually irregular intervals. The occurences are separated by an interval in which the sign, symptom, or manifestation is not present. [] ||| bacteremic infections definition: Infections by bacteria, general or unspecified. ||| Neisseria definition: A genus of gram-negative, aerobic, coccoid bacteria whose organisms are part of the normal flora of the oropharynx, nasopharynx, and genitourinary tract. Some species are primary pathogens for humans. ||| Output:

@@Familial deficiency of the seventh component of complement## associated with recurrent @@bacteremic infections due to Neisseria##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Familial deficiency of the seventh component of complement associated with recurrent bacteremic infections due to Neisseria. Useful knowledge : ||| Familial deficiency definition: Familial LCAT (lecithin-cholesterol acyltransferase) deficiency (FLD) is a form of lecithin-cholesterol acyltransferase deficiency (LCAT; see this term) characterized clinically by corneal opacities, hemolytic anemia, and renal failure, and biochemically by severely decreased HDL cholesterol and complete deficiency of the LCAT enzyme. ||| complement definition: The complement system is a complex system of serum proteins that interact in a cascade. Many of the early components are serine proteases that activate each other sequentially. This complement system consists of three separate activation triggers: (1) Ab binding to a cell surface, (2) formation of immune complexes, and (3) a carbohydrate component of a microbe's cell membrane. Along with this triggers, there are also two sets of mechanisms. Both of these mechanisms, classical pathway and alternative or properdin pathway, make MAC (Membrane Attack Complex), which can lyse and destroy the cell. ||| associated with definition: Joined in some kind of relationship. ||| recurrent definition: Applied to a sign, symptom, or other manifestation that occurs multiple times at usually irregular intervals. The occurences are separated by an interval in which the sign, symptom, or manifestation is not present. [] ||| bacteremic infections definition: Infections by bacteria, general or unspecified. ||| Neisseria definition: A genus of gram-negative, aerobic, coccoid bacteria whose organisms are part of the normal flora of the oropharynx, nasopharynx, and genitourinary tract. Some species are primary pathogens for humans. ||| Output: [/INST] @@Familial deficiency of the seventh component of complement## associated with recurrent @@bacteremic infections due to Neisseria##.

@@Familial deficiency of the seventh component of complement## associated with recurrent @@bacteremic infections due to Neisseria##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The serum of a 29-year old woman with a recent episode of disseminated gonococcal infection and a history of meningococcal meningitis and arthritis as a child was found to lack serum hemolytic complement activity. Useful knowledge : ||| serum definition: The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins. ||| woman definition: Human females as cultural, psychological, sociological, political, and economic entities. ||| episode definition: A noteworthy happening that is distinctive in a series of related events. ||| disseminated definition: To scatter widely; spread. ||| gonococcal infection definition: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879. ||| history definition: Record and study of past events. ||| meningococcal meningitis definition: A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8) ||| arthritis definition: Acute or chronic inflammation of JOINTS. ||| child definition: A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. ||| serum hemolytic complement activity definition: A screening assay for circulating COMPLEMENT PROTEINS. Diluted SERUM samples are added to antibody-coated ERYTHROCYTES and the percentage of cell lysis is measured. The values are expressed by the so called CH50, in HEMOLYTIC COMPLEMENT units per milliliter, which is the dilution of serum required to lyse 50 percent of the erythrocytes in the assay. ||| Output:

The serum of a 29-year old woman with a recent episode of @@disseminated gonococcal infection## and a history of @@meningococcal meningitis## and @@arthritis## as a child was found to lack serum hemolytic complement activity.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The serum of a 29-year old woman with a recent episode of disseminated gonococcal infection and a history of meningococcal meningitis and arthritis as a child was found to lack serum hemolytic complement activity. Useful knowledge : ||| serum definition: The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins. ||| woman definition: Human females as cultural, psychological, sociological, political, and economic entities. ||| episode definition: A noteworthy happening that is distinctive in a series of related events. ||| disseminated definition: To scatter widely; spread. ||| gonococcal infection definition: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879. ||| history definition: Record and study of past events. ||| meningococcal meningitis definition: A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8) ||| arthritis definition: Acute or chronic inflammation of JOINTS. ||| child definition: A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. ||| serum hemolytic complement activity definition: A screening assay for circulating COMPLEMENT PROTEINS. Diluted SERUM samples are added to antibody-coated ERYTHROCYTES and the percentage of cell lysis is measured. The values are expressed by the so called CH50, in HEMOLYTIC COMPLEMENT units per milliliter, which is the dilution of serum required to lyse 50 percent of the erythrocytes in the assay. ||| Output: [/INST] The serum of a 29-year old woman with a recent episode of @@disseminated gonococcal infection## and a history of @@meningococcal meningitis## and @@arthritis## as a child was found to lack serum hemolytic complement activity.

The serum of a 29-year old woman with a recent episode of @@disseminated gonococcal infection## and a history of @@meningococcal meningitis## and @@arthritis## as a child was found to lack serum hemolytic complement activity.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The seventh component of complement (C7) was not detected by functional or immunochemical assays, whereas other components were normal by hemolytic and immunochemical assessment. Useful knowledge : ||| C7 definition: None ||| functional definition: None ||| immunochemical assays definition: The determination of the amount of islet cell antibody present in a sample. ||| components definition: None ||| hemolytic definition: None ||| Output:

The seventh component of complement (C7) was not detected by functional or immunochemical assays, whereas other components were normal by hemolytic and immunochemical assessment.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The seventh component of complement (C7) was not detected by functional or immunochemical assays, whereas other components were normal by hemolytic and immunochemical assessment. Useful knowledge : ||| C7 definition: None ||| functional definition: None ||| immunochemical assays definition: The determination of the amount of islet cell antibody present in a sample. ||| components definition: None ||| hemolytic definition: None ||| Output: [/INST] The seventh component of complement (C7) was not detected by functional or immunochemical assays, whereas other components were normal by hemolytic and immunochemical assessment.

The seventh component of complement (C7) was not detected by functional or immunochemical assays, whereas other components were normal by hemolytic and immunochemical assessment.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Her fresh serum lacked complement-mediated bactericidal activity against Neisseria gonorrhoeae, but the addition of fresh normal serum or purified C7 restored bactericidal activity as well as hemolytic activity. Useful knowledge : ||| fresh definition: Not previously used. ||| serum definition: The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins. ||| Neisseria gonorrhoeae definition: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA. ||| fresh definition: Not previously used. ||| purified definition: The process of removing impurities. ||| C7 definition: None ||| bactericidal activity definition: None ||| hemolytic activity definition: Disruption of the integrity of the erythrocyte membrane causing release of hemoglobin. ||| Output:

Her fresh serum lacked complement-mediated bactericidal activity against Neisseria gonorrhoeae, but the addition of fresh normal serum or purified C7 restored bactericidal activity as well as hemolytic activity.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Her fresh serum lacked complement-mediated bactericidal activity against Neisseria gonorrhoeae, but the addition of fresh normal serum or purified C7 restored bactericidal activity as well as hemolytic activity. Useful knowledge : ||| fresh definition: Not previously used. ||| serum definition: The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins. ||| Neisseria gonorrhoeae definition: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA. ||| fresh definition: Not previously used. ||| purified definition: The process of removing impurities. ||| C7 definition: None ||| bactericidal activity definition: None ||| hemolytic activity definition: Disruption of the integrity of the erythrocyte membrane causing release of hemoglobin. ||| Output: [/INST] Her fresh serum lacked complement-mediated bactericidal activity against Neisseria gonorrhoeae, but the addition of fresh normal serum or purified C7 restored bactericidal activity as well as hemolytic activity.

Her fresh serum lacked complement-mediated bactericidal activity against Neisseria gonorrhoeae, but the addition of fresh normal serum or purified C7 restored bactericidal activity as well as hemolytic activity.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The absence of functional C7 activity could not be accounted for on the basis of an inhibitor. Useful knowledge : ||| absence definition: Not existing in a specified place at a specified time. ||| functional definition: None ||| C7 activity definition: Body movements of a human or an animal as a behavioral phenomenon. ||| inhibitor definition: A class of substances that binds to and inhibits the function or activity of a target. ||| Output:

The @@absence of functional C7## activity could not be accounted for on the basis of an inhibitor.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The absence of functional C7 activity could not be accounted for on the basis of an inhibitor. Useful knowledge : ||| absence definition: Not existing in a specified place at a specified time. ||| functional definition: None ||| C7 activity definition: Body movements of a human or an animal as a behavioral phenomenon. ||| inhibitor definition: A class of substances that binds to and inhibits the function or activity of a target. ||| Output: [/INST] The @@absence of functional C7## activity could not be accounted for on the basis of an inhibitor.

The @@absence of functional C7## activity could not be accounted for on the basis of an inhibitor.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Opsonization and generation of chemotactic activity functioned normally. Useful knowledge : ||| Opsonization definition: The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149] ||| generation definition: A single step in the line of descent from a common ancestor. ||| chemotactic activity definition: Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult. ||| Output:

Opsonization and generation of chemotactic activity functioned normally.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Opsonization and generation of chemotactic activity functioned normally. Useful knowledge : ||| Opsonization definition: The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149] ||| generation definition: A single step in the line of descent from a common ancestor. ||| chemotactic activity definition: Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult. ||| Output: [/INST] Opsonization and generation of chemotactic activity functioned normally.

Opsonization and generation of chemotactic activity functioned normally.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Complete absence of C7 was also found in one sibling who had the clinical syndrome of meningococcal meningitis and arthritis as a child and in this siblings clinically well eight-year-old son. Useful knowledge : ||| Complete definition: To possess every necessary or normal part or component or step; having come or been brought to a conclusion. ||| absence definition: Not existing in a specified place at a specified time. ||| C7 definition: None ||| sibling definition: Interactions and relationships between sisters and/or brothers. The concept also applies to animal studies. ||| clinical syndrome definition: None ||| meningococcal meningitis definition: A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8) ||| arthritis definition: Acute or chronic inflammation of JOINTS. ||| child definition: A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. ||| siblings definition: Persons or animals having at least one parent in common. (American College Dictionary, 3d ed) ||| clinically definition: Relating to the examination and treatment of patients dependent on direct observation. The term may also refer to the institution (clinic) providing this activity. ||| Output:

@@Complete absence of C7## was also found in one sibling who had the clinical syndrome of @@meningococcal meningitis## and @@arthritis## as a child and in this siblings clinically well eight-year-old son.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Complete absence of C7 was also found in one sibling who had the clinical syndrome of meningococcal meningitis and arthritis as a child and in this siblings clinically well eight-year-old son. Useful knowledge : ||| Complete definition: To possess every necessary or normal part or component or step; having come or been brought to a conclusion. ||| absence definition: Not existing in a specified place at a specified time. ||| C7 definition: None ||| sibling definition: Interactions and relationships between sisters and/or brothers. The concept also applies to animal studies. ||| clinical syndrome definition: None ||| meningococcal meningitis definition: A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8) ||| arthritis definition: Acute or chronic inflammation of JOINTS. ||| child definition: A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. ||| siblings definition: Persons or animals having at least one parent in common. (American College Dictionary, 3d ed) ||| clinically definition: Relating to the examination and treatment of patients dependent on direct observation. The term may also refer to the institution (clinic) providing this activity. ||| Output: [/INST] @@Complete absence of C7## was also found in one sibling who had the clinical syndrome of @@meningococcal meningitis## and @@arthritis## as a child and in this siblings clinically well eight-year-old son.

@@Complete absence of C7## was also found in one sibling who had the clinical syndrome of @@meningococcal meningitis## and @@arthritis## as a child and in this siblings clinically well eight-year-old son.