Datasets:

rntc

/

ncbi_disease_knowledge_0_shots_train

like 0

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 121 761-774). Useful knowledge : ||| Output:

121 761-774).

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 121 761-774). Useful knowledge : ||| Output: [/INST] 121 761-774).

121 761-774).

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The PTS1R mRNA is expressed in all human tissues examined. Useful knowledge : ||| PTS1R definition: None ||| mRNA definition: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. ||| expressed definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. ||| human definition: Members of the species Homo sapiens. ||| tissues definition: Collections of differentiated CELLS, such as EPITHELIUM; CONNECTIVE TISSUE; MUSCLES; and NERVE TISSUE. Tissues are cooperatively arranged to form organs with specialized functions such as RESPIRATION; DIGESTION; REPRODUCTION; MOVEMENT; and others. ||| Output:

The PTS1R mRNA is expressed in all human tissues examined.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The PTS1R mRNA is expressed in all human tissues examined. Useful knowledge : ||| PTS1R definition: None ||| mRNA definition: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. ||| expressed definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. ||| human definition: Members of the species Homo sapiens. ||| tissues definition: Collections of differentiated CELLS, such as EPITHELIUM; CONNECTIVE TISSUE; MUSCLES; and NERVE TISSUE. Tissues are cooperatively arranged to form organs with specialized functions such as RESPIRATION; DIGESTION; REPRODUCTION; MOVEMENT; and others. ||| Output: [/INST] The PTS1R mRNA is expressed in all human tissues examined.

The PTS1R mRNA is expressed in all human tissues examined.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells. Useful knowledge : ||| Antibodies definition: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS). ||| human definition: Members of the species Homo sapiens. ||| PTS1R definition: None ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| human definition: Members of the species Homo sapiens. ||| monkey definition: Any haplorhine primate not belonging to the family Tarsiidae, Hylobatidae, Pongidae, or Hominidae; this does not correspond to any taxon. This group is divided into Old World monkeys (Cercopithecidae) and New World monkeys (Callitrichidae and Cebidae). Many types are used as an experimental model for human disease and drug testing. ||| rat definition: The common rat, Rattus norvegicus, often used as an experimental organism. ||| hamster cells definition: Any member of four genera of the rodent family Cricetidae; short-tailed Old World burrowing rodents with large cheek pouches. ||| Output:

Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells. Useful knowledge : ||| Antibodies definition: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS). ||| human definition: Members of the species Homo sapiens. ||| PTS1R definition: None ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| human definition: Members of the species Homo sapiens. ||| monkey definition: Any haplorhine primate not belonging to the family Tarsiidae, Hylobatidae, Pongidae, or Hominidae; this does not correspond to any taxon. This group is divided into Old World monkeys (Cercopithecidae) and New World monkeys (Callitrichidae and Cebidae). Many types are used as an experimental model for human disease and drug testing. ||| rat definition: The common rat, Rattus norvegicus, often used as an experimental organism. ||| hamster cells definition: Any member of four genera of the rodent family Cricetidae; short-tailed Old World burrowing rodents with large cheek pouches. ||| Output: [/INST] Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells.

Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The protein is localized mainly in the cytosol but is also found to be associated with peroxisomes. Useful knowledge : ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| localized definition: Being confined or restricted to a particular location. [HPO:probinson] ||| cytosol definition: Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components. ||| associated with definition: Joined in some kind of relationship. ||| peroxisomes definition: Microbodies which occur in animal and plant cells and in certain fungi and protozoa. They contain peroxidase, catalase, and allied enzymes. (From Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology, 2nd ed) ||| Output:

The protein is localized mainly in the cytosol but is also found to be associated with peroxisomes.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The protein is localized mainly in the cytosol but is also found to be associated with peroxisomes. Useful knowledge : ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| localized definition: Being confined or restricted to a particular location. [HPO:probinson] ||| cytosol definition: Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components. ||| associated with definition: Joined in some kind of relationship. ||| peroxisomes definition: Microbodies which occur in animal and plant cells and in certain fungi and protozoa. They contain peroxidase, catalase, and allied enzymes. (From Singleton and Sainsbury, Dictionary of Microbiology and Molecular Biology, 2nd ed) ||| Output: [/INST] The protein is localized mainly in the cytosol but is also found to be associated with peroxisomes.

The protein is localized mainly in the cytosol but is also found to be associated with peroxisomes.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Part of the peroxisomal PTS1R protein is tightly bound to the peroxisomal membrane. Useful knowledge : ||| peroxisomal definition: None ||| peroxisomal membrane definition: The lipid bilayer surrounding a peroxisome. [GOC:mah] ||| Output:

Part of the peroxisomal PTS1R protein is tightly bound to the peroxisomal membrane.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Part of the peroxisomal PTS1R protein is tightly bound to the peroxisomal membrane. Useful knowledge : ||| peroxisomal definition: None ||| peroxisomal membrane definition: The lipid bilayer surrounding a peroxisome. [GOC:mah] ||| Output: [/INST] Part of the peroxisomal PTS1R protein is tightly bound to the peroxisomal membrane.

Part of the peroxisomal PTS1R protein is tightly bound to the peroxisomal membrane.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Antibodies to PTS1R inhibit peroxisomal protein-import of PTS1-containing proteins in a permeabilized CHO cell system. Useful knowledge : ||| Antibodies definition: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS). ||| PTS1R definition: None ||| inhibit definition: The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process. ||| peroxisomal protein-import definition: A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners. [PMID:12667447, PMID:20154681, PMID:22375831] ||| permeabilized definition: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions. ||| CHO cell definition: CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells. ||| Output:

Antibodies to PTS1R inhibit peroxisomal protein-import of PTS1-containing proteins in a permeabilized CHO cell system.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Antibodies to PTS1R inhibit peroxisomal protein-import of PTS1-containing proteins in a permeabilized CHO cell system. Useful knowledge : ||| Antibodies definition: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS). ||| PTS1R definition: None ||| inhibit definition: The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process. ||| peroxisomal protein-import definition: A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners. [PMID:12667447, PMID:20154681, PMID:22375831] ||| permeabilized definition: Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions. ||| CHO cell definition: CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells. ||| Output: [/INST] Antibodies to PTS1R inhibit peroxisomal protein-import of PTS1-containing proteins in a permeabilized CHO cell system.

Antibodies to PTS1R inhibit peroxisomal protein-import of PTS1-containing proteins in a permeabilized CHO cell system.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In vitro-translated PTS1R protein specifically binds a serine-lysine-leucine-peptide. Useful knowledge : ||| Output:

In vitro-translated PTS1R protein specifically binds a serine-lysine-leucine-peptide.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In vitro-translated PTS1R protein specifically binds a serine-lysine-leucine-peptide. Useful knowledge : ||| Output: [/INST] In vitro-translated PTS1R protein specifically binds a serine-lysine-leucine-peptide.

In vitro-translated PTS1R protein specifically binds a serine-lysine-leucine-peptide.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant. Useful knowledge : ||| fusion protein definition: A protein in which the coding region of two genes have become in-frame and co-continuous. Fusion proteins can be formed by chromosomal breakage and/or recombination and also can be experimentally created using recombinant DNA techniques. ||| Output:

A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant. Useful knowledge : ||| fusion protein definition: A protein in which the coding region of two genes have become in-frame and co-continuous. Fusion proteins can be formed by chromosomal breakage and/or recombination and also can be experimentally created using recombinant DNA techniques. ||| Output: [/INST] A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.

A PAS8-PTS1R fusion protein complements the P. pastoris pas8 mutant.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The PTS1R cDNA also complements the PTS1 protein-import defect in skin fibroblasts from patients--belonging to complementation group two--diagnosed as having neonatal adrenoleukodystrophy or Zellweger syndrome. Useful knowledge : ||| PTS1R definition: None ||| cDNA definition: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe. ||| skin fibroblasts definition: None ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| complementation group definition: This gene may be involved in the mediation of DNA repair. ||| diagnosed definition: The determination of the nature of a disease or condition, or the distinguishing of one disease or condition from another. Assessment may be made through physical examination, laboratory tests, or the likes. Computerized programs may be used to enhance the decision-making process. ||| neonatal adrenoleukodystrophy definition: A rare metabolic disorder that affects neonates. It is characterized by damage of the white matter in the brain and degeneration of the adrenal glands. It manifests with hyperactivity, paralysis, muscular weakness, crossed eyes, hearing loss, seizures, and coma. ||| Zellweger syndrome definition: An autosomal recessive disorder due to defects in PEROXISOME biogenesis which involves more than 13 genes encoding peroxin proteins of the peroxisomal membrane and matrix. Zellweger syndrome is typically seen in the neonatal period with features such as dysmorphic skull; MUSCLE HYPOTONIA; SENSORINEURAL HEARING LOSS; visual compromise; SEIZURES; progressive degeneration of the KIDNEYS and the LIVER. Zellweger-like syndrome refers to phenotypes resembling the neonatal Zellweger syndrome but seen in children or adults with apparently intact peroxisome biogenesis. ||| Output:

The PTS1R cDNA also complements the @@PTS1 protein-import defect## in skin fibroblasts from patients--belonging to complementation group two--diagnosed as having @@neonatal adrenoleukodystrophy## or @@Zellweger syndrome##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The PTS1R cDNA also complements the PTS1 protein-import defect in skin fibroblasts from patients--belonging to complementation group two--diagnosed as having neonatal adrenoleukodystrophy or Zellweger syndrome. Useful knowledge : ||| PTS1R definition: None ||| cDNA definition: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe. ||| skin fibroblasts definition: None ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| complementation group definition: This gene may be involved in the mediation of DNA repair. ||| diagnosed definition: The determination of the nature of a disease or condition, or the distinguishing of one disease or condition from another. Assessment may be made through physical examination, laboratory tests, or the likes. Computerized programs may be used to enhance the decision-making process. ||| neonatal adrenoleukodystrophy definition: A rare metabolic disorder that affects neonates. It is characterized by damage of the white matter in the brain and degeneration of the adrenal glands. It manifests with hyperactivity, paralysis, muscular weakness, crossed eyes, hearing loss, seizures, and coma. ||| Zellweger syndrome definition: An autosomal recessive disorder due to defects in PEROXISOME biogenesis which involves more than 13 genes encoding peroxin proteins of the peroxisomal membrane and matrix. Zellweger syndrome is typically seen in the neonatal period with features such as dysmorphic skull; MUSCLE HYPOTONIA; SENSORINEURAL HEARING LOSS; visual compromise; SEIZURES; progressive degeneration of the KIDNEYS and the LIVER. Zellweger-like syndrome refers to phenotypes resembling the neonatal Zellweger syndrome but seen in children or adults with apparently intact peroxisome biogenesis. ||| Output: [/INST] The PTS1R cDNA also complements the @@PTS1 protein-import defect## in skin fibroblasts from patients--belonging to complementation group two--diagnosed as having @@neonatal adrenoleukodystrophy## or @@Zellweger syndrome##.

The PTS1R cDNA also complements the @@PTS1 protein-import defect## in skin fibroblasts from patients--belonging to complementation group two--diagnosed as having @@neonatal adrenoleukodystrophy## or @@Zellweger syndrome##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The PTS1R gene has been localized to a chromosomal location where no other peroxisomal disorder genes are known to map. Useful knowledge : ||| localized definition: Being confined or restricted to a particular location. [HPO:probinson] ||| chromosomal location definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| peroxisomal disorder definition: A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders. ||| genes definition: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. ||| map definition: A usually 2-dimensional diagrammatic representation of an object or area. ||| Output:

The PTS1R gene has been localized to a chromosomal location where no other @@peroxisomal disorder## genes are known to map.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The PTS1R gene has been localized to a chromosomal location where no other peroxisomal disorder genes are known to map. Useful knowledge : ||| localized definition: Being confined or restricted to a particular location. [HPO:probinson] ||| chromosomal location definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| peroxisomal disorder definition: A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders. ||| genes definition: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. ||| map definition: A usually 2-dimensional diagrammatic representation of an object or area. ||| Output: [/INST] The PTS1R gene has been localized to a chromosomal location where no other @@peroxisomal disorder## genes are known to map.

The PTS1R gene has been localized to a chromosomal location where no other @@peroxisomal disorder## genes are known to map.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Our findings represent the only case in which the molecular basis of the protein-import deficiency in human peroxisomal disorders is understood. Useful knowledge : ||| findings definition: None ||| case definition: None ||| molecular basis definition: Relating to or produced by or consisting of molecules. ||| protein-import deficiency definition: A nutritional condition produced by a deficiency of proteins in the diet, characterized by adaptive enzyme changes in the liver, increase in amino acid synthetases, and diminution of urea formation, thus conserving nitrogen and reducing its loss in the urine. Growth, immune response, repair, and production of enzymes and hormones are all impaired in severe protein deficiency. Protein deficiency may also arise in the face of adequate protein intake if the protein is of poor quality (i.e., the content of one or more amino acids is inadequate and thus becomes the limiting factor in protein utilization). (From Merck Manual, 16th ed; Harrison's Principles of Internal Medicine, 12th ed, p406) ||| human definition: Members of the species Homo sapiens. ||| peroxisomal disorders definition: A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders. ||| Output:

Our findings represent the only case in which the molecular basis of the @@protein-import deficiency## in human @@peroxisomal disorders## is understood.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Our findings represent the only case in which the molecular basis of the protein-import deficiency in human peroxisomal disorders is understood. Useful knowledge : ||| findings definition: None ||| case definition: None ||| molecular basis definition: Relating to or produced by or consisting of molecules. ||| protein-import deficiency definition: A nutritional condition produced by a deficiency of proteins in the diet, characterized by adaptive enzyme changes in the liver, increase in amino acid synthetases, and diminution of urea formation, thus conserving nitrogen and reducing its loss in the urine. Growth, immune response, repair, and production of enzymes and hormones are all impaired in severe protein deficiency. Protein deficiency may also arise in the face of adequate protein intake if the protein is of poor quality (i.e., the content of one or more amino acids is inadequate and thus becomes the limiting factor in protein utilization). (From Merck Manual, 16th ed; Harrison's Principles of Internal Medicine, 12th ed, p406) ||| human definition: Members of the species Homo sapiens. ||| peroxisomal disorders definition: A heterogeneous group of inherited metabolic disorders marked by absent or dysfunctional PEROXISOMES. Peroxisomal enzymatic abnormalities may be single or multiple. Biosynthetic peroxisomal pathways are compromised, including the ability to synthesize ether lipids and to oxidize long-chain fatty acid precursors. Diseases in this category include ZELLWEGER SYNDROME; INFANTILE REFSUM DISEASE; rhizomelic chondrodysplasia (CHONDRODYSPLASIA PUNCTATA, RHIZOMELIC); hyperpipecolic acidemia; neonatal adrenoleukodystrophy; and ADRENOLEUKODYSTROPHY (X-linked). Neurologic dysfunction is a prominent feature of most peroxisomal disorders. ||| Output: [/INST] Our findings represent the only case in which the molecular basis of the @@protein-import deficiency## in human @@peroxisomal disorders## is understood.

Our findings represent the only case in which the molecular basis of the @@protein-import deficiency## in human @@peroxisomal disorders## is understood.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: X-linked spastic paraplegia and Pelizaeus-Merzbacher disease are allelic disorders at the proteolipid protein locus. Useful knowledge : ||| X-linked spastic paraplegia definition: An X-linked recessive condition caused by mutation(s) in the L1CAM gene, encoding neural cell adhesion molecule L1. It is characterized by mental retardation, aphasia, shuffling gait and adducted thumbs. ||| Pelizaeus-Merzbacher disease definition: A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS, CONGENITAL. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190) ||| allelic disorders definition: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen. ||| proteolipid protein definition: This gene is involved in neuronal development. ||| locus definition: The position of a gene or a chromosomal marker on a chromosome; also, a stretch of DNA at a particular place on a particular chromosome. The use of locus is sometimes restricted to mean regions of DNA that are expressed. ||| Output:

@@X-linked spastic paraplegia## and @@Pelizaeus-Merzbacher disease## are @@allelic disorders## at the proteolipid protein locus.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: X-linked spastic paraplegia and Pelizaeus-Merzbacher disease are allelic disorders at the proteolipid protein locus. Useful knowledge : ||| X-linked spastic paraplegia definition: An X-linked recessive condition caused by mutation(s) in the L1CAM gene, encoding neural cell adhesion molecule L1. It is characterized by mental retardation, aphasia, shuffling gait and adducted thumbs. ||| Pelizaeus-Merzbacher disease definition: A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS, CONGENITAL. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190) ||| allelic disorders definition: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen. ||| proteolipid protein definition: This gene is involved in neuronal development. ||| locus definition: The position of a gene or a chromosomal marker on a chromosome; also, a stretch of DNA at a particular place on a particular chromosome. The use of locus is sometimes restricted to mean regions of DNA that are expressed. ||| Output: [/INST] @@X-linked spastic paraplegia## and @@Pelizaeus-Merzbacher disease## are @@allelic disorders## at the proteolipid protein locus.

@@X-linked spastic paraplegia## and @@Pelizaeus-Merzbacher disease## are @@allelic disorders## at the proteolipid protein locus.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Three forms of X-linked spastic paraplegia (SPG) have been defined. Useful knowledge : ||| X-linked spastic paraplegia definition: An X-linked recessive condition caused by mutation(s) in the L1CAM gene, encoding neural cell adhesion molecule L1. It is characterized by mental retardation, aphasia, shuffling gait and adducted thumbs. ||| SPG definition: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8) ||| Output:

Three forms of @@X-linked spastic paraplegia## (@@SPG##) have been defined.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Three forms of X-linked spastic paraplegia (SPG) have been defined. Useful knowledge : ||| X-linked spastic paraplegia definition: An X-linked recessive condition caused by mutation(s) in the L1CAM gene, encoding neural cell adhesion molecule L1. It is characterized by mental retardation, aphasia, shuffling gait and adducted thumbs. ||| SPG definition: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8) ||| Output: [/INST] Three forms of @@X-linked spastic paraplegia## (@@SPG##) have been defined.

Three forms of @@X-linked spastic paraplegia## (@@SPG##) have been defined.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: One locus (SPG 1) maps to Xq28 while two clinically distinct forms map to Xq22 (SPG2). Useful knowledge : ||| One locus definition: The position of a gene or a chromosomal marker on a chromosome; also, a stretch of DNA at a particular place on a particular chromosome. The use of locus is sometimes restricted to mean regions of DNA that are expressed. ||| SPG 1 definition: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8) ||| maps definition: A usually 2-dimensional diagrammatic representation of an object or area. ||| Xq28 definition: A chromosome band present on Xq ||| clinically definition: Relating to the examination and treatment of patients dependent on direct observation. The term may also refer to the institution (clinic) providing this activity. ||| map definition: A usually 2-dimensional diagrammatic representation of an object or area. ||| Xq22 definition: A chromosome band present on Xq ||| SPG2 definition: This gene is involved in neuronal development. ||| Output:

One locus (SPG 1) maps to Xq28 while two clinically distinct forms map to Xq22 (SPG2).

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: One locus (SPG 1) maps to Xq28 while two clinically distinct forms map to Xq22 (SPG2). Useful knowledge : ||| One locus definition: The position of a gene or a chromosomal marker on a chromosome; also, a stretch of DNA at a particular place on a particular chromosome. The use of locus is sometimes restricted to mean regions of DNA that are expressed. ||| SPG 1 definition: A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8) ||| maps definition: A usually 2-dimensional diagrammatic representation of an object or area. ||| Xq28 definition: A chromosome band present on Xq ||| clinically definition: Relating to the examination and treatment of patients dependent on direct observation. The term may also refer to the institution (clinic) providing this activity. ||| map definition: A usually 2-dimensional diagrammatic representation of an object or area. ||| Xq22 definition: A chromosome band present on Xq ||| SPG2 definition: This gene is involved in neuronal development. ||| Output: [/INST] One locus (SPG 1) maps to Xq28 while two clinically distinct forms map to Xq22 (SPG2).

One locus (SPG 1) maps to Xq28 while two clinically distinct forms map to Xq22 (SPG2).

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: A rare X-linked dysmyelinating disorder of the central nervous system, Pelizaeus-Merzbacher disease (PMD), has also been mapped to Xq21-q22, and is caused by mutations in the proteolipid protein gene (PLP) which encodes two myelin proteins, PLP and DM20. Useful knowledge : ||| rare definition: Not occurring regularly or at short intervals. ||| central nervous system definition: None ||| Pelizaeus-Merzbacher disease definition: A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS, CONGENITAL. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190) ||| PMD definition: A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS, CONGENITAL. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190) ||| mapped definition: The process of connecting an item or symbol to a code or concept. ||| Xq21-q22 definition: A chromosome band present on Xq ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| proteolipid protein gene definition: This gene is involved in neuronal development. ||| PLP definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). ||| encodes definition: To assign a code to represent data. ||| myelin proteins definition: MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure. ||| PLP definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). ||| DM20 definition: This gene is involved in neuronal development. ||| Output:

A rare @@X-linked dysmyelinating disorder## of the central nervous system, @@Pelizaeus-Merzbacher disease## (@@PMD##), has also been mapped to Xq21-q22, and is caused by mutations in the proteolipid protein gene (PLP) which encodes two myelin proteins, PLP and DM20.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: A rare X-linked dysmyelinating disorder of the central nervous system, Pelizaeus-Merzbacher disease (PMD), has also been mapped to Xq21-q22, and is caused by mutations in the proteolipid protein gene (PLP) which encodes two myelin proteins, PLP and DM20. Useful knowledge : ||| rare definition: Not occurring regularly or at short intervals. ||| central nervous system definition: None ||| Pelizaeus-Merzbacher disease definition: A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS, CONGENITAL. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190) ||| PMD definition: A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS, CONGENITAL. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190) ||| mapped definition: The process of connecting an item or symbol to a code or concept. ||| Xq21-q22 definition: A chromosome band present on Xq ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| proteolipid protein gene definition: This gene is involved in neuronal development. ||| PLP definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). ||| encodes definition: To assign a code to represent data. ||| myelin proteins definition: MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure. ||| PLP definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). ||| DM20 definition: This gene is involved in neuronal development. ||| Output: [/INST] A rare @@X-linked dysmyelinating disorder## of the central nervous system, @@Pelizaeus-Merzbacher disease## (@@PMD##), has also been mapped to Xq21-q22, and is caused by mutations in the proteolipid protein gene (PLP) which encodes two myelin proteins, PLP and DM20.

A rare @@X-linked dysmyelinating disorder## of the central nervous system, @@Pelizaeus-Merzbacher disease## (@@PMD##), has also been mapped to Xq21-q22, and is caused by mutations in the proteolipid protein gene (PLP) which encodes two myelin proteins, PLP and DM20.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: While narrowing the genetic interval containing SPG2 in a large pedigree, we found that PLP was the closest marker to the disease locus, implicating PLP as a possible candidate gene. Useful knowledge : ||| genetic interval definition: A time period, or other type of interval, during which something may be achieved, obtained or observed. ||| SPG2 definition: This gene is involved in neuronal development. ||| pedigree definition: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition. ||| PLP definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). ||| marker definition: A visual indicator of position, place or route. ||| disease locus definition: A disease that is confined to a specific organ or tissue and has not spread to other anatomic sites. ||| PLP definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). ||| gene definition: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. ||| Output:

While narrowing the genetic interval containing SPG2 in a large pedigree, we found that PLP was the closest marker to the disease locus, implicating PLP as a possible candidate gene.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: While narrowing the genetic interval containing SPG2 in a large pedigree, we found that PLP was the closest marker to the disease locus, implicating PLP as a possible candidate gene. Useful knowledge : ||| genetic interval definition: A time period, or other type of interval, during which something may be achieved, obtained or observed. ||| SPG2 definition: This gene is involved in neuronal development. ||| pedigree definition: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition. ||| PLP definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). ||| marker definition: A visual indicator of position, place or route. ||| disease locus definition: A disease that is confined to a specific organ or tissue and has not spread to other anatomic sites. ||| PLP definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). ||| gene definition: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. ||| Output: [/INST] While narrowing the genetic interval containing SPG2 in a large pedigree, we found that PLP was the closest marker to the disease locus, implicating PLP as a possible candidate gene.

While narrowing the genetic interval containing SPG2 in a large pedigree, we found that PLP was the closest marker to the disease locus, implicating PLP as a possible candidate gene.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: We have found that a point mutation (His139Tyr) in exon 3B of an affected male produces a mutant PLP but a normal DM20, and segregates with the disease (Zmax = 6. Useful knowledge : ||| point mutation definition: A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair. ||| affected definition: To be influenced by or changed. ||| male definition: A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both. ||| mutant definition: An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). ||| PLP definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). ||| DM20 definition: This gene is involved in neuronal development. ||| segregates definition: Barriers based on ethnicity or other group group membership. ||| disease definition: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. ||| Output:

We have found that a point mutation (His139Tyr) in exon 3B of an affected male produces a mutant PLP but a normal DM20, and segregates with the disease (Zmax = 6.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: We have found that a point mutation (His139Tyr) in exon 3B of an affected male produces a mutant PLP but a normal DM20, and segregates with the disease (Zmax = 6. Useful knowledge : ||| point mutation definition: A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair. ||| affected definition: To be influenced by or changed. ||| male definition: A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both. ||| mutant definition: An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). ||| PLP definition: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE). ||| DM20 definition: This gene is involved in neuronal development. ||| segregates definition: Barriers based on ethnicity or other group group membership. ||| disease definition: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. ||| Output: [/INST] We have found that a point mutation (His139Tyr) in exon 3B of an affected male produces a mutant PLP but a normal DM20, and segregates with the disease (Zmax = 6.

We have found that a point mutation (His139Tyr) in exon 3B of an affected male produces a mutant PLP but a normal DM20, and segregates with the disease (Zmax = 6.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 63, theta = 0. Useful knowledge : ||| Output:

63, theta = 0.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 63, theta = 0. Useful knowledge : ||| Output: [/INST] 63, theta = 0.

63, theta = 0.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 00). Useful knowledge : ||| Output:

00).

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 00). Useful knowledge : ||| Output: [/INST] 00).

00).

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: It appears, therefore, that SPG2 and PMD are allelic disorders Useful knowledge : ||| SPG2 definition: This gene is involved in neuronal development. ||| PMD definition: A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS, CONGENITAL. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190) ||| allelic disorders definition: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen. ||| Output:

It appears, therefore, that SPG2 and @@PMD## are @@allelic disorders##

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: It appears, therefore, that SPG2 and PMD are allelic disorders Useful knowledge : ||| SPG2 definition: This gene is involved in neuronal development. ||| PMD definition: A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS, CONGENITAL. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190) ||| allelic disorders definition: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen. ||| Output: [/INST] It appears, therefore, that SPG2 and @@PMD## are @@allelic disorders##

It appears, therefore, that SPG2 and @@PMD## are @@allelic disorders##