Datasets:

rntc

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ncbi_disease_knowledge_0_shots_train

like 0

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: A common human skin tumour is caused by activating mutations in beta-catenin. Useful knowledge : ||| human definition: Members of the species Homo sapiens. ||| skin tumour definition: Tumors or cancer of the SKIN. ||| activating definition: To cause something to start or to stimulate activity. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output:

A common human @@skin tumour## is caused by activating mutations in beta-catenin.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: A common human skin tumour is caused by activating mutations in beta-catenin. Useful knowledge : ||| human definition: Members of the species Homo sapiens. ||| skin tumour definition: Tumors or cancer of the SKIN. ||| activating definition: To cause something to start or to stimulate activity. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output: [/INST] A common human @@skin tumour## is caused by activating mutations in beta-catenin.

A common human @@skin tumour## is caused by activating mutations in beta-catenin.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: WNT signalling orchestrates a number of developmental programs. Useful knowledge : ||| signalling definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] ||| developmental programs definition: The process of formulating, improving, and expanding educational, managerial, or service-oriented work plans (excluding computer program development). ||| Output:

WNT signalling orchestrates a number of developmental programs.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: WNT signalling orchestrates a number of developmental programs. Useful knowledge : ||| signalling definition: The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] ||| developmental programs definition: The process of formulating, improving, and expanding educational, managerial, or service-oriented work plans (excluding computer program development). ||| Output: [/INST] WNT signalling orchestrates a number of developmental programs.

WNT signalling orchestrates a number of developmental programs.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family. Useful knowledge : ||| response definition: Any act or phenomena, or behavior, constituting a reply or reaction of a living organism or its part to some foregoing stimulus or agent. ||| stimulus definition: An environmental event, agent, act, or influence that can be detected by a receptor in the body and will invariably produce a reaction in a living organism, e.g. change in the behavior, functional or trophic reaction. ||| cytoplasmic definition: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990) ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| CTNNB1 definition: This gene is involved in signal transduction and regulation of transcription. ||| stabilized definition: Condition did not change and required not further care to maintain condition ||| downstream definition: None ||| transcriptional activation definition: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes. ||| Output:

In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family. Useful knowledge : ||| response definition: Any act or phenomena, or behavior, constituting a reply or reaction of a living organism or its part to some foregoing stimulus or agent. ||| stimulus definition: An environmental event, agent, act, or influence that can be detected by a receptor in the body and will invariably produce a reaction in a living organism, e.g. change in the behavior, functional or trophic reaction. ||| cytoplasmic definition: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990) ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| CTNNB1 definition: This gene is involved in signal transduction and regulation of transcription. ||| stabilized definition: Condition did not change and required not further care to maintain condition ||| downstream definition: None ||| transcriptional activation definition: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes. ||| Output: [/INST] In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family.

In response to this stimulus, cytoplasmic beta-catenin (encoded by CTNNB1) is stabilized, enabling downstream transcriptional activation by members of the LEF/TCF family.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: One of the target genes for beta-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to cancer, particularly in the colon. Useful knowledge : ||| target genes definition: A gene proposed to have a primary role in a disease, based upon its known function in other organisms or model systems or based upon its physical proximity to markers linked to a genetic disease. ||| c-MYC definition: None ||| constitutive activation definition: Nuclear receptor subfamily 1 group I member 3 (352 aa, ~40 kDa) is encoded by the human NR1I3 gene. This protein is involved in the regulation of xenobiotic and endobiotic metabolism. ||| WNT pathway definition: A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| colon definition: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON. ||| Output:

One of the target genes for beta-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to @@cancer##, particularly in the colon.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: One of the target genes for beta-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to cancer, particularly in the colon. Useful knowledge : ||| target genes definition: A gene proposed to have a primary role in a disease, based upon its known function in other organisms or model systems or based upon its physical proximity to markers linked to a genetic disease. ||| c-MYC definition: None ||| constitutive activation definition: Nuclear receptor subfamily 1 group I member 3 (352 aa, ~40 kDa) is encoded by the human NR1I3 gene. This protein is involved in the regulation of xenobiotic and endobiotic metabolism. ||| WNT pathway definition: A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| colon definition: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON. ||| Output: [/INST] One of the target genes for beta-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to @@cancer##, particularly in the colon.

One of the target genes for beta-catenin/TCF encodes c-MYC, explaining why constitutive activation of the WNT pathway can lead to @@cancer##, particularly in the colon.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Most colon cancers arise from mutations in the gene encoding adenomatous polyposis coli (APC), a protein required for ubiquitin-mediated degradation of beta-catenin, but a small percentage of colon and some other cancers harbour beta-catenin-stabilizing mutations. Useful knowledge : ||| colon cancers definition: A primary or metastatic malignant neoplasm that affects the colon. Representative examples include carcinoma, lymphoma, and sarcoma. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| gene definition: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. ||| encoding definition: None ||| adenomatous polyposis coli ( definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| ubiquitin-mediated degradation definition: Ubiquitinated Protein Degradation involves the regulated covalent conjugation of one or more ubiquitin residues to one or more sites on a protein that acts as a tag by which the protein-transport machinery ferries the targeted ubiquinated protein to the proteasome for proteolytic destruction. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| colon definition: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON. ||| cancers definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| Output:

Most @@colon cancers## arise from mutations in the gene encoding @@adenomatous polyposis coli## (@@APC##), a protein required for ubiquitin-mediated degradation of beta-catenin, but a small percentage of @@colon and some other cancers## harbour beta-catenin-stabilizing mutations.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Most colon cancers arise from mutations in the gene encoding adenomatous polyposis coli (APC), a protein required for ubiquitin-mediated degradation of beta-catenin, but a small percentage of colon and some other cancers harbour beta-catenin-stabilizing mutations. Useful knowledge : ||| colon cancers definition: A primary or metastatic malignant neoplasm that affects the colon. Representative examples include carcinoma, lymphoma, and sarcoma. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| gene definition: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. ||| encoding definition: None ||| adenomatous polyposis coli ( definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| ubiquitin-mediated degradation definition: Ubiquitinated Protein Degradation involves the regulated covalent conjugation of one or more ubiquitin residues to one or more sites on a protein that acts as a tag by which the protein-transport machinery ferries the targeted ubiquinated protein to the proteasome for proteolytic destruction. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| colon definition: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON. ||| cancers definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| Output: [/INST] Most @@colon cancers## arise from mutations in the gene encoding @@adenomatous polyposis coli## (@@APC##), a protein required for ubiquitin-mediated degradation of beta-catenin, but a small percentage of @@colon and some other cancers## harbour beta-catenin-stabilizing mutations.

Most @@colon cancers## arise from mutations in the gene encoding @@adenomatous polyposis coli## (@@APC##), a protein required for ubiquitin-mediated degradation of beta-catenin, but a small percentage of @@colon and some other cancers## harbour beta-catenin-stabilizing mutations.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Recently, we discovered that transgenic mice expressing an activated beta-catenin are predisposed to developing skin tumours resembling pilomatricomas. Useful knowledge : ||| transgenic mice definition: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. ||| expressing definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. ||| activated definition: To cause something to start or to stimulate activity. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| predisposed definition: None ||| skin tumours definition: Tumors or cancer of the SKIN. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| Output:

Recently, we discovered that transgenic mice expressing an activated beta-catenin are predisposed to developing @@skin tumours## resembling @@pilomatricomas##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Recently, we discovered that transgenic mice expressing an activated beta-catenin are predisposed to developing skin tumours resembling pilomatricomas. Useful knowledge : ||| transgenic mice definition: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. ||| expressing definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. ||| activated definition: To cause something to start or to stimulate activity. ||| beta-catenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| predisposed definition: None ||| skin tumours definition: Tumors or cancer of the SKIN. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| Output: [/INST] Recently, we discovered that transgenic mice expressing an activated beta-catenin are predisposed to developing @@skin tumours## resembling @@pilomatricomas##.

Recently, we discovered that transgenic mice expressing an activated beta-catenin are predisposed to developing @@skin tumours## resembling @@pilomatricomas##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human pilomatricomas might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations. Useful knowledge : ||| skin definition: None ||| adult definition: A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. ||| mice definition: The common mouse species, Mus musculus. ||| de novo definition: Anew, afresh, or over again from the beginning. ||| hair-follicle morphogenesis definition: The process in which the anatomical structures of the hair follicle are generated and organized. [GOC:ln] ||| human definition: Members of the species Homo sapiens. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| hair matrix cells definition: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound. ||| Output:

Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human @@pilomatricomas## might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human pilomatricomas might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations. Useful knowledge : ||| skin definition: None ||| adult definition: A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. ||| mice definition: The common mouse species, Mus musculus. ||| de novo definition: Anew, afresh, or over again from the beginning. ||| hair-follicle morphogenesis definition: The process in which the anatomical structures of the hair follicle are generated and organized. [GOC:ln] ||| human definition: Members of the species Homo sapiens. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| hair matrix cells definition: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound. ||| Output: [/INST] Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human @@pilomatricomas## might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations.

Given that the skin of these adult mice also exhibits signs of de novo hair-follicle morphogenesis, we wondered whether human @@pilomatricomas## might originate from hair matrix cells and whether they might possess beta-catenin-stabilizing mutations.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Here, we explore the cell origin and aetiology of this common human skin tumour. Useful knowledge : ||| cell origin definition: The name of the cell from which the biological specimen was derived. ||| aetiology definition: Used with diseases for causative agents including microorganisms and includes environmental and social factors and personal habits as contributing factors. It includes pathogenesis. ||| human definition: Members of the species Homo sapiens. ||| skin tumour definition: Tumors or cancer of the SKIN. ||| Output:

Here, we explore the cell origin and aetiology of this common human @@skin tumour##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Here, we explore the cell origin and aetiology of this common human skin tumour. Useful knowledge : ||| cell origin definition: The name of the cell from which the biological specimen was derived. ||| aetiology definition: Used with diseases for causative agents including microorganisms and includes environmental and social factors and personal habits as contributing factors. It includes pathogenesis. ||| human definition: Members of the species Homo sapiens. ||| skin tumour definition: Tumors or cancer of the SKIN. ||| Output: [/INST] Here, we explore the cell origin and aetiology of this common human @@skin tumour##.

Here, we explore the cell origin and aetiology of this common human @@skin tumour##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: We found nuclear LEF-1 in the dividing tumour cells, providing biochemical evidence that pilomatricomas are derived from hair matrix cells. Useful knowledge : ||| nuclear definition: Pertaining to the nucleus. ||| LEF-1 definition: Lymphoid enhancer-binding factor 1 (399 aa, ~44 kDa) is encoded by the human LEF1 gene. This protein is involved in Wnt signaling and transcriptional regulation. ||| biochemical definition: Of or relating to biochemistry; involving chemical processes in living organisms. ||| evidence definition: Knowledge on which to base belief. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| hair matrix cells definition: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound. ||| Output:

We found nuclear LEF-1 in the dividing @@tumour## cells, providing biochemical evidence that @@pilomatricomas## are derived from hair matrix cells.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: We found nuclear LEF-1 in the dividing tumour cells, providing biochemical evidence that pilomatricomas are derived from hair matrix cells. Useful knowledge : ||| nuclear definition: Pertaining to the nucleus. ||| LEF-1 definition: Lymphoid enhancer-binding factor 1 (399 aa, ~44 kDa) is encoded by the human LEF1 gene. This protein is involved in Wnt signaling and transcriptional regulation. ||| biochemical definition: Of or relating to biochemistry; involving chemical processes in living organisms. ||| evidence definition: Knowledge on which to base belief. ||| pilomatricomas definition: A tumor composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It is a relatively uncommon tumor, which may occur at any age from infancy. The majority of patients are under 20, and females are affected more than males. The lesion is usually a solitary deep dermal or subcutaneous tumor 3-30 mm in diameter, situated in the head, neck, or upper extremity. (From Rook et al., Textbook of Dermatology, 4th ed, p2401) ||| hair matrix cells definition: Sensory cells in the organ of Corti, characterized by their apical stereocilia (hair-like projections). The inner and outer hair cells, as defined by their proximity to the core of spongy bone (the modiolus), change morphologically along the COCHLEA. Towards the cochlear apex, the length of hair cell bodies and their apical STEREOCILIA increase, allowing differential responses to various frequencies of sound. ||| Output: [/INST] We found nuclear LEF-1 in the dividing @@tumour## cells, providing biochemical evidence that @@pilomatricomas## are derived from hair matrix cells.

We found nuclear LEF-1 in the dividing @@tumour## cells, providing biochemical evidence that @@pilomatricomas## are derived from hair matrix cells.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: At least 75% of these tumours possess mutations affecting the amino-terminal segment, normally involved in phosphorylation-dependent, ubiquitin-mediated degradation of the protein. Useful knowledge : ||| tumours definition: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| affecting definition: To be influenced by or changed. ||| amino-terminal segment definition: The amino acid residing in the first position of a protein or peptide. ||| phosphorylation-dependent definition: Binding to a protein upon phosphorylation of the target protein. [PMID:26060076] ||| ubiquitin-mediated degradation definition: Ubiquitinated Protein Degradation involves the regulated covalent conjugation of one or more ubiquitin residues to one or more sites on a protein that acts as a tag by which the protein-transport machinery ferries the targeted ubiquinated protein to the proteasome for proteolytic destruction. ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| Output:

At least 75% of these @@tumours## possess mutations affecting the amino-terminal segment, normally involved in phosphorylation-dependent, ubiquitin-mediated degradation of the protein.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: At least 75% of these tumours possess mutations affecting the amino-terminal segment, normally involved in phosphorylation-dependent, ubiquitin-mediated degradation of the protein. Useful knowledge : ||| tumours definition: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| affecting definition: To be influenced by or changed. ||| amino-terminal segment definition: The amino acid residing in the first position of a protein or peptide. ||| phosphorylation-dependent definition: Binding to a protein upon phosphorylation of the target protein. [PMID:26060076] ||| ubiquitin-mediated degradation definition: Ubiquitinated Protein Degradation involves the regulated covalent conjugation of one or more ubiquitin residues to one or more sites on a protein that acts as a tag by which the protein-transport machinery ferries the targeted ubiquinated protein to the proteasome for proteolytic destruction. ||| protein definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. ||| Output: [/INST] At least 75% of these @@tumours## possess mutations affecting the amino-terminal segment, normally involved in phosphorylation-dependent, ubiquitin-mediated degradation of the protein.

At least 75% of these @@tumours## possess mutations affecting the amino-terminal segment, normally involved in phosphorylation-dependent, ubiquitin-mediated degradation of the protein.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This percentage of CTNNB1 mutations is greater than in all other human tumours examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans.. Useful knowledge : ||| percentage definition: A unit for expressing a number as a fraction of hundred (on the basis of a rate or proportion per hundred). ||| CTNNB1 definition: This gene is involved in signal transduction and regulation of transcription. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| human tumours definition: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. ||| hair matrix cell definition: Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components. ||| tumorigenesis definition: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. ||| humans definition: Members of the species Homo sapiens. ||| Output:

This percentage of CTNNB1 mutations is greater than in all other human @@tumours## examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans..

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This percentage of CTNNB1 mutations is greater than in all other human tumours examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans.. Useful knowledge : ||| percentage definition: A unit for expressing a number as a fraction of hundred (on the basis of a rate or proportion per hundred). ||| CTNNB1 definition: This gene is involved in signal transduction and regulation of transcription. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| human tumours definition: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. ||| hair matrix cell definition: Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components. ||| tumorigenesis definition: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill. ||| humans definition: Members of the species Homo sapiens. ||| Output: [/INST] This percentage of CTNNB1 mutations is greater than in all other human @@tumours## examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans..

This percentage of CTNNB1 mutations is greater than in all other human @@tumours## examined thus far, and directly implicates beta-catenin/LEF misregulation as the major cause of hair matrix cell tumorigenesis in humans..

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HFE mutations analysis in 711 hemochromatosis probands: evidence for S65C implication in mild form of hemochromatosis. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| probands definition: None ||| evidence definition: Knowledge on which to base belief. ||| mild form definition: Gentle or temperate in nature or degree. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| Output:

HFE mutations analysis in 711 @@hemochromatosis## probands: evidence for S65C implication in mild form of @@hemochromatosis##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HFE mutations analysis in 711 hemochromatosis probands: evidence for S65C implication in mild form of hemochromatosis. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| probands definition: None ||| evidence definition: Knowledge on which to base belief. ||| mild form definition: Gentle or temperate in nature or degree. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| Output: [/INST] HFE mutations analysis in 711 @@hemochromatosis## probands: evidence for S65C implication in mild form of @@hemochromatosis##.

HFE mutations analysis in 711 @@hemochromatosis## probands: evidence for S65C implication in mild form of @@hemochromatosis##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Hereditary hemochromatosis (HH) is a common autosomal recessive genetic disorder of iron metabolism. Useful knowledge : ||| Hereditary hemochromatosis definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| HH definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| autosomal definition: Any chromosome other than a sex chromosome. [GOC:mah] ||| iron metabolism definition: sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosynthesis) and catabolism of iron; the buildup and breakdown of iron for utilization by the organism. ||| Output:

@@Hereditary hemochromatosis## (@@HH##) is a common @@autosomal recessive genetic disorder## of iron metabolism.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Hereditary hemochromatosis (HH) is a common autosomal recessive genetic disorder of iron metabolism. Useful knowledge : ||| Hereditary hemochromatosis definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| HH definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| autosomal definition: Any chromosome other than a sex chromosome. [GOC:mah] ||| iron metabolism definition: sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosynthesis) and catabolism of iron; the buildup and breakdown of iron for utilization by the organism. ||| Output: [/INST] @@Hereditary hemochromatosis## (@@HH##) is a common @@autosomal recessive genetic disorder## of iron metabolism.

@@Hereditary hemochromatosis## (@@HH##) is a common @@autosomal recessive genetic disorder## of iron metabolism.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The HFE candidate gene encoding an HLA class I-like protein involved in HH was identified in 1996. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| encoding definition: None ||| HH definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| identified definition: The procedure of having an identity established. ||| Output:

The HFE candidate gene encoding an HLA class I-like protein involved in @@HH## was identified in 1996.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The HFE candidate gene encoding an HLA class I-like protein involved in HH was identified in 1996. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| encoding definition: None ||| HH definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| identified definition: The procedure of having an identity established. ||| Output: [/INST] The HFE candidate gene encoding an HLA class I-like protein involved in @@HH## was identified in 1996.

The HFE candidate gene encoding an HLA class I-like protein involved in @@HH## was identified in 1996.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Two missense mutations have been described C282Y, accounting for 80% to 90% of HH chromosomes, and H63D, which is associated with a milder form of the disease representing 40% to 70% of non-C282Y HH chromosomes. Useful knowledge : ||| missense mutations definition: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed) ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| associated with definition: Joined in some kind of relationship. ||| disease definition: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| Output:

Two missense mutations have been described C282Y, accounting for 80% to 90% of @@HH## chromosomes, and H63D, which is associated with a milder form of the disease representing 40% to 70% of non-C282Y @@HH## chromosomes.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Two missense mutations have been described C282Y, accounting for 80% to 90% of HH chromosomes, and H63D, which is associated with a milder form of the disease representing 40% to 70% of non-C282Y HH chromosomes. Useful knowledge : ||| missense mutations definition: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed) ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| associated with definition: Joined in some kind of relationship. ||| disease definition: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| Output: [/INST] Two missense mutations have been described C282Y, accounting for 80% to 90% of @@HH## chromosomes, and H63D, which is associated with a milder form of the disease representing 40% to 70% of non-C282Y @@HH## chromosomes.

Two missense mutations have been described C282Y, accounting for 80% to 90% of @@HH## chromosomes, and H63D, which is associated with a milder form of the disease representing 40% to 70% of non-C282Y @@HH## chromosomes.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: We report here on the analysis of C282Y, H63D, and the 193A-- > T substitution leading to the S65C missense substitution in a large series of probands and controls. Useful knowledge : ||| report definition: Detailed account or statement or formal record of the proceedings of a meeting or session. May also document status or progress of an activity or research project. ||| analysis definition: None ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| missense definition: None ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| probands definition: None ||| controls definition: The containment, regulation, or restraint of costs. Costs are said to be contained when the value of resources committed to an activity is not considered excessive. This determination is frequently subjective and dependent upon the specific geographic area of the activity being measured. (From Dictionary of Health Services Management, 2d ed) ||| Output:

We report here on the analysis of C282Y, H63D, and the 193A-- > T substitution leading to the S65C missense substitution in a large series of probands and controls.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: We report here on the analysis of C282Y, H63D, and the 193A-- > T substitution leading to the S65C missense substitution in a large series of probands and controls. Useful knowledge : ||| report definition: Detailed account or statement or formal record of the proceedings of a meeting or session. May also document status or progress of an activity or research project. ||| analysis definition: None ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| missense definition: None ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| probands definition: None ||| controls definition: The containment, regulation, or restraint of costs. Costs are said to be contained when the value of resources committed to an activity is not considered excessive. This determination is frequently subjective and dependent upon the specific geographic area of the activity being measured. (From Dictionary of Health Services Management, 2d ed) ||| Output: [/INST] We report here on the analysis of C282Y, H63D, and the 193A-- > T substitution leading to the S65C missense substitution in a large series of probands and controls.

We report here on the analysis of C282Y, H63D, and the 193A-- > T substitution leading to the S65C missense substitution in a large series of probands and controls.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The results confirm that the C282Y substitution was the main mutation involved in hemochromatosis, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the HH chromosomes that did not carry the C282Y mutation. Useful knowledge : ||| results definition: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition. ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| carrier chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output:

The results confirm that the C282Y substitution was the main mutation involved in @@hemochromatosis##, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the @@HH## chromosomes that did not carry the C282Y mutation.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The results confirm that the C282Y substitution was the main mutation involved in hemochromatosis, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the HH chromosomes that did not carry the C282Y mutation. Useful knowledge : ||| results definition: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition. ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| carrier chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output: [/INST] The results confirm that the C282Y substitution was the main mutation involved in @@hemochromatosis##, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the @@HH## chromosomes that did not carry the C282Y mutation.

The results confirm that the C282Y substitution was the main mutation involved in @@hemochromatosis##, accounting for 85% of carrier chromosomes, whereas the H63D substitution represented 39% of the @@HH## chromosomes that did not carry the C282Y mutation.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In addition, our screening showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation. Useful knowledge : ||| screening definition: Procedures performed on people to identify those who have NEOPLASMS or PRENEOPLASTIC CONDITIONS. ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| probands definition: None ||| chromosome definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| assigned definition: An allotting or an appointment to a particular person or use, or for a particular time or object. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output:

In addition, our screening showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In addition, our screening showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation. Useful knowledge : ||| screening definition: Procedures performed on people to identify those who have NEOPLASMS or PRENEOPLASTIC CONDITIONS. ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| probands definition: None ||| chromosome definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| assigned definition: An allotting or an appointment to a particular person or use, or for a particular time or object. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output: [/INST] In addition, our screening showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation.

In addition, our screening showed that the S65C substitution was significantly enriched in probands with at least one chromosome without an assigned mutation.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This substitution accounted for 7. Useful knowledge : ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| Output:

This substitution accounted for 7.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This substitution accounted for 7. Useful knowledge : ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| Output: [/INST] This substitution accounted for 7.

This substitution accounted for 7.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 8% of HH chromosomes that were neither C282Y nor H63D. Useful knowledge : ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| Output:

8% of @@HH## chromosomes that were neither C282Y nor H63D.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 8% of HH chromosomes that were neither C282Y nor H63D. Useful knowledge : ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| Output: [/INST] 8% of @@HH## chromosomes that were neither C282Y nor H63D.

8% of @@HH## chromosomes that were neither C282Y nor H63D.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This enrichment of S65C among HH chromosomes suggests that the S65C substitution is associated with the mild form of hemochromatosis. Useful knowledge : ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| associated with definition: Joined in some kind of relationship. ||| mild form definition: Gentle or temperate in nature or degree. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| Output:

This enrichment of S65C among @@HH## chromosomes suggests that the S65C substitution is associated with the mild form of @@hemochromatosis##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This enrichment of S65C among HH chromosomes suggests that the S65C substitution is associated with the mild form of hemochromatosis. Useful knowledge : ||| HH chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| substitution definition: <p>Definition: Indicates that the subject Act has undergone or should undergo substitution of a type indicated by Act.code.</p><p>Rationale: Used to specify "allowed" substitution when creating orders, "actual" susbstitution when sending events, as well as the reason for the substitution and who was responsible for it.</p> ||| associated with definition: Joined in some kind of relationship. ||| mild form definition: Gentle or temperate in nature or degree. ||| hemochromatosis definition: A disorder of iron metabolism characterized by a triad of HEMOSIDEROSIS; LIVER CIRRHOSIS; and DIABETES MELLITUS. It is caused by massive iron deposits in parenchymal cells that may develop after a prolonged increase of iron absorption. (Jablonski's Dictionary of Syndromes & Eponymic Diseases, 2d ed) ||| Output: [/INST] This enrichment of S65C among @@HH## chromosomes suggests that the S65C substitution is associated with the mild form of @@hemochromatosis##.

This enrichment of S65C among @@HH## chromosomes suggests that the S65C substitution is associated with the mild form of @@hemochromatosis##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Germline BRCA1 alterations in a population-based series of ovarian cancer cases. Useful knowledge : ||| Germline definition: None ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| Output:

Germline BRCA1 alterations in a population-based series of @@ovarian cancer## cases.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Germline BRCA1 alterations in a population-based series of ovarian cancer cases. Useful knowledge : ||| Germline definition: None ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| Output: [/INST] Germline BRCA1 alterations in a population-based series of @@ovarian cancer## cases.

Germline BRCA1 alterations in a population-based series of @@ovarian cancer## cases.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The objective of this study was to provide more accurate frequency estimates of breast cancer susceptibility gene 1 (BRCA1) germline alterations in the ovarian cancer population. Useful knowledge : ||| objective definition: The end-result or objective, which may be specified or required in advance. ||| study definition: A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. ||| accurate definition: The quality of nearness to the truth or the true value. ||| frequency definition: None ||| estimates definition: To calculate approximately. ||| breast cancer definition: A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males. ||| susceptibility gene 1 definition: Mutated forms of genes which encode proteins that are essential for the control and maintenance of normal cellular processes. Inherited or somatic mutations in the wild-type form of these genes alters control of their expression, resulting in a change in control of the cell cycle. Individuals who harbor cancer-predisposing genes require fewer somatic mutations for transformation of a particular cell, thereby predisposing them to the development of cancer. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| germline alterations definition: Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| population definition: The total number of individuals inhabiting a particular region or area. ||| Output:

The objective of this study was to provide more accurate frequency estimates of @@breast cancer## susceptibility gene 1 (BRCA1) germline alterations in the @@ovarian cancer## population.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The objective of this study was to provide more accurate frequency estimates of breast cancer susceptibility gene 1 (BRCA1) germline alterations in the ovarian cancer population. Useful knowledge : ||| objective definition: The end-result or objective, which may be specified or required in advance. ||| study definition: A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. ||| accurate definition: The quality of nearness to the truth or the true value. ||| frequency definition: None ||| estimates definition: To calculate approximately. ||| breast cancer definition: A primary or metastatic malignant neoplasm involving the breast. The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple. Malignant breast neoplasms occur more frequently in females than in males. ||| susceptibility gene 1 definition: Mutated forms of genes which encode proteins that are essential for the control and maintenance of normal cellular processes. Inherited or somatic mutations in the wild-type form of these genes alters control of their expression, resulting in a change in control of the cell cycle. Individuals who harbor cancer-predisposing genes require fewer somatic mutations for transformation of a particular cell, thereby predisposing them to the development of cancer. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| germline alterations definition: Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| population definition: The total number of individuals inhabiting a particular region or area. ||| Output: [/INST] The objective of this study was to provide more accurate frequency estimates of @@breast cancer## susceptibility gene 1 (BRCA1) germline alterations in the @@ovarian cancer## population.

The objective of this study was to provide more accurate frequency estimates of @@breast cancer## susceptibility gene 1 (BRCA1) germline alterations in the @@ovarian cancer## population.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: To achieve this, we determined the prevalence of BRCA1 alterations in a population-based series of consecutive ovarian cancer cases. Useful knowledge : ||| prevalence definition: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| consecutive definition: In regular succession without gaps. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| Output:

To achieve this, we determined the prevalence of BRCA1 alterations in a population-based series of consecutive @@ovarian cancer## cases.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: To achieve this, we determined the prevalence of BRCA1 alterations in a population-based series of consecutive ovarian cancer cases. Useful knowledge : ||| prevalence definition: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| consecutive definition: In regular succession without gaps. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| Output: [/INST] To achieve this, we determined the prevalence of BRCA1 alterations in a population-based series of consecutive @@ovarian cancer## cases.

To achieve this, we determined the prevalence of BRCA1 alterations in a population-based series of consecutive @@ovarian cancer## cases.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This is the first population-based ovarian cancer study reporting BRCA1 alterations derived from a comprehensive screen of the entire coding region. Useful knowledge : ||| study definition: A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| comprehensive definition: Broad in scope; including all or everything. ||| screen definition: An electronic device designed as a display or a physical device designed to be a protective meshwork. ||| coding region definition: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR). ||| Output:

This is the first population-based @@ovarian cancer## study reporting BRCA1 alterations derived from a comprehensive screen of the entire coding region.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This is the first population-based ovarian cancer study reporting BRCA1 alterations derived from a comprehensive screen of the entire coding region. Useful knowledge : ||| study definition: A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| comprehensive definition: Broad in scope; including all or everything. ||| screen definition: An electronic device designed as a display or a physical device designed to be a protective meshwork. ||| coding region definition: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR). ||| Output: [/INST] This is the first population-based @@ovarian cancer## study reporting BRCA1 alterations derived from a comprehensive screen of the entire coding region.

This is the first population-based @@ovarian cancer## study reporting BRCA1 alterations derived from a comprehensive screen of the entire coding region.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: One hundred and seven ovarian cancer cases were analyzed for BRCA1 alterations using the RNase mismatch cleavage assay followed by direct sequencing. Useful knowledge : ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| analyzed definition: Examination and interpretation; the process of identifying an issue to be understood and addressed, modelling the issue, investigating the model results, interpreting the results, and possibly making a recommendation. The concept also refers to the examination and study of a whole in terms of the parts composing it. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| RNase definition: A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-. ||| direct sequencing definition: A technique used to identify the sequence of individual nucleobases in a single strand of DNA fragment template, which can be a plasmid insert, genomic DNA or a PCR product. In addition, direct sequencing of genomic DNA or PCR products does not require sub-cloning of the gene of interest into a vector. ||| Output:

One hundred and seven @@ovarian cancer## cases were analyzed for BRCA1 alterations using the RNase mismatch cleavage assay followed by direct sequencing.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: One hundred and seven ovarian cancer cases were analyzed for BRCA1 alterations using the RNase mismatch cleavage assay followed by direct sequencing. Useful knowledge : ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| cases definition: None ||| analyzed definition: Examination and interpretation; the process of identifying an issue to be understood and addressed, modelling the issue, investigating the model results, interpreting the results, and possibly making a recommendation. The concept also refers to the examination and study of a whole in terms of the parts composing it. ||| BRCA1 definition: A tumor suppressor gene (GENES, TUMOR SUPPRESSOR) located on human CHROMOSOME 17 at locus 17q21. Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. It encodes a large nuclear protein that is a component of DNA repair pathways. ||| alterations definition: The act or process of modifying something. ||| RNase definition: A family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-. ||| direct sequencing definition: A technique used to identify the sequence of individual nucleobases in a single strand of DNA fragment template, which can be a plasmid insert, genomic DNA or a PCR product. In addition, direct sequencing of genomic DNA or PCR products does not require sub-cloning of the gene of interest into a vector. ||| Output: [/INST] One hundred and seven @@ovarian cancer## cases were analyzed for BRCA1 alterations using the RNase mismatch cleavage assay followed by direct sequencing.

One hundred and seven @@ovarian cancer## cases were analyzed for BRCA1 alterations using the RNase mismatch cleavage assay followed by direct sequencing.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Two truncating mutations, 962del4 and 3600del11, were identified. Useful knowledge : ||| truncating definition: Translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| identified definition: The procedure of having an identity established. ||| Output:

Two truncating mutations, 962del4 and 3600del11, were identified.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Two truncating mutations, 962del4 and 3600del11, were identified. Useful knowledge : ||| truncating definition: Translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| identified definition: The procedure of having an identity established. ||| Output: [/INST] Two truncating mutations, 962del4 and 3600del11, were identified.

Two truncating mutations, 962del4 and 3600del11, were identified.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Both patients had a family history of breast or ovarian cancer. Useful knowledge : ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| family history of definition: A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. ||| breast definition: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| Output:

Both patients had a family history of @@breast or ovarian cancer##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Both patients had a family history of breast or ovarian cancer. Useful knowledge : ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| family history of definition: A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. ||| breast definition: In humans, one of the paired regions in the anterior portion of the THORAX. The breasts consist of the MAMMARY GLANDS, the SKIN, the MUSCLES, the ADIPOSE TISSUE, and the CONNECTIVE TISSUES. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| Output: [/INST] Both patients had a family history of @@breast or ovarian cancer##.

Both patients had a family history of @@breast or ovarian cancer##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Several novel as well as previously reported uncharacterized variants were also identified, some of which were associated with a family history of cancer. Useful knowledge : ||| uncharacterized definition: The act of describing distinctive characteristics or essential features. ||| variants definition: An alteration or difference from a norm or standard. ||| identified definition: The procedure of having an identity established. ||| associated with definition: Joined in some kind of relationship. ||| family history of cancer definition: A record of a patient's medical background regarding the cancer and cancer-related problems of blood relatives. ||| Output:

Several novel as well as previously reported uncharacterized variants were also identified, some of which were associated with a family history of @@cancer##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Several novel as well as previously reported uncharacterized variants were also identified, some of which were associated with a family history of cancer. Useful knowledge : ||| uncharacterized definition: The act of describing distinctive characteristics or essential features. ||| variants definition: An alteration or difference from a norm or standard. ||| identified definition: The procedure of having an identity established. ||| associated with definition: Joined in some kind of relationship. ||| family history of cancer definition: A record of a patient's medical background regarding the cancer and cancer-related problems of blood relatives. ||| Output: [/INST] Several novel as well as previously reported uncharacterized variants were also identified, some of which were associated with a family history of @@cancer##.

Several novel as well as previously reported uncharacterized variants were also identified, some of which were associated with a family history of @@cancer##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The frequency distribution of common polymorphisms was determined in the 91 Caucasian cancer cases in this series and 24 sister controls using allele-specific amplification. Useful knowledge : ||| frequency definition: None ||| distribution definition: The placement, arrangement of instance of entities within a space. ||| polymorphisms definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| Caucasian definition: A group distinguished by classification according to physical features. This group, also called Europoid, centers around the Mediterranean Sea but includes other parts of Europe. (from Winick: Dictionary of Anthropology, 1972; American Heritage Dictionary, 2d College ed) ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| cases definition: None ||| series definition: A group or succession of objects, substances, or events arranged in regular order in space or time, connected by a like relation, or forming a kind of chain. ||| sister controls definition: The containment, regulation, or restraint of costs. Costs are said to be contained when the value of resources committed to an activity is not considered excessive. This determination is frequently subjective and dependent upon the specific geographic area of the activity being measured. (From Dictionary of Health Services Management, 2d ed) ||| Output:

The frequency distribution of common polymorphisms was determined in the 91 Caucasian @@cancer## cases in this series and 24 sister controls using allele-specific amplification.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The frequency distribution of common polymorphisms was determined in the 91 Caucasian cancer cases in this series and 24 sister controls using allele-specific amplification. Useful knowledge : ||| frequency definition: None ||| distribution definition: The placement, arrangement of instance of entities within a space. ||| polymorphisms definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| Caucasian definition: A group distinguished by classification according to physical features. This group, also called Europoid, centers around the Mediterranean Sea but includes other parts of Europe. (from Winick: Dictionary of Anthropology, 1972; American Heritage Dictionary, 2d College ed) ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| cases definition: None ||| series definition: A group or succession of objects, substances, or events arranged in regular order in space or time, connected by a like relation, or forming a kind of chain. ||| sister controls definition: The containment, regulation, or restraint of costs. Costs are said to be contained when the value of resources committed to an activity is not considered excessive. This determination is frequently subjective and dependent upon the specific geographic area of the activity being measured. (From Dictionary of Health Services Management, 2d ed) ||| Output: [/INST] The frequency distribution of common polymorphisms was determined in the 91 Caucasian @@cancer## cases in this series and 24 sister controls using allele-specific amplification.

The frequency distribution of common polymorphisms was determined in the 91 Caucasian @@cancer## cases in this series and 24 sister controls using allele-specific amplification.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The rare form of the Q356R polymorphism was significantly (P = 0. Useful knowledge : ||| rare definition: Not occurring regularly or at short intervals. ||| polymorphism definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| Output:

The rare form of the Q356R polymorphism was significantly (P = 0.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The rare form of the Q356R polymorphism was significantly (P = 0. Useful knowledge : ||| rare definition: Not occurring regularly or at short intervals. ||| polymorphism definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| Output: [/INST] The rare form of the Q356R polymorphism was significantly (P = 0.

The rare form of the Q356R polymorphism was significantly (P = 0.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 03) associated with a family history of ovarian cancer, suggesting that this polymorphism may influence ovarian cancer risk. Useful knowledge : ||| associated with definition: Joined in some kind of relationship. ||| family history of definition: A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| polymorphism definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| influence definition: The power to have an effect on people, things, or events. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| risk definition: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome. ||| Output:

03) associated with a family history of @@ovarian cancer##, suggesting that this polymorphism may influence @@ovarian cancer## risk.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 03) associated with a family history of ovarian cancer, suggesting that this polymorphism may influence ovarian cancer risk. Useful knowledge : ||| associated with definition: Joined in some kind of relationship. ||| family history of definition: A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| polymorphism definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| influence definition: The power to have an effect on people, things, or events. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| risk definition: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome. ||| Output: [/INST] 03) associated with a family history of @@ovarian cancer##, suggesting that this polymorphism may influence @@ovarian cancer## risk.

03) associated with a family history of @@ovarian cancer##, suggesting that this polymorphism may influence @@ovarian cancer## risk.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In summary, our data suggest a role for some uncharacterized variants and rare forms of polymorphisms in determining ovarian cancer risk, and highlight the necessity to screen for missense alterations as well as truncating mutations in this population. Useful knowledge : ||| data definition: A collection or single item of factual information, derived from measurement or research, from which conclusions may be drawn. ||| uncharacterized definition: The act of describing distinctive characteristics or essential features. ||| variants definition: An alteration or difference from a norm or standard. ||| polymorphisms definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| risk definition: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome. ||| missense definition: None ||| alterations definition: The act or process of modifying something. ||| truncating definition: Translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| population definition: The total number of individuals inhabiting a particular region or area. ||| Output:

In summary, our data suggest a role for some uncharacterized variants and rare forms of polymorphisms in determining @@ovarian cancer## risk, and highlight the necessity to screen for missense alterations as well as truncating mutations in this population.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In summary, our data suggest a role for some uncharacterized variants and rare forms of polymorphisms in determining ovarian cancer risk, and highlight the necessity to screen for missense alterations as well as truncating mutations in this population. Useful knowledge : ||| data definition: A collection or single item of factual information, derived from measurement or research, from which conclusions may be drawn. ||| uncharacterized definition: The act of describing distinctive characteristics or essential features. ||| variants definition: An alteration or difference from a norm or standard. ||| polymorphisms definition: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. ||| ovarian cancer definition: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. ||| risk definition: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome. ||| missense definition: None ||| alterations definition: The act or process of modifying something. ||| truncating definition: Translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| population definition: The total number of individuals inhabiting a particular region or area. ||| Output: [/INST] In summary, our data suggest a role for some uncharacterized variants and rare forms of polymorphisms in determining @@ovarian cancer## risk, and highlight the necessity to screen for missense alterations as well as truncating mutations in this population.

In summary, our data suggest a role for some uncharacterized variants and rare forms of polymorphisms in determining @@ovarian cancer## risk, and highlight the necessity to screen for missense alterations as well as truncating mutations in this population.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Useful knowledge : ||| Identification definition: A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| homologue definition: A gene from one species which corresponds to a gene in another species and that is related via a common ancestral species. These genes retain a similar sequence and function. ||| adenomatous polyposis coli definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| tumour suppressor definition: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible. ||| Output:

Identification of APC2, a homologue of the @@adenomatous polyposis coli tumour## suppressor.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Useful knowledge : ||| Identification definition: A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| homologue definition: A gene from one species which corresponds to a gene in another species and that is related via a common ancestral species. These genes retain a similar sequence and function. ||| adenomatous polyposis coli definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| tumour suppressor definition: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible. ||| Output: [/INST] Identification of APC2, a homologue of the @@adenomatous polyposis coli tumour## suppressor.

Identification of APC2, a homologue of the @@adenomatous polyposis coli tumour## suppressor.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The adenomatous polyposis coli (APC) tumour-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin. Useful knowledge : ||| adenomatous polyposis coli (APC) definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| tumour-suppressor protein definition: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development. ||| Wnt signalling pathway definition: A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. ||| complex definition: Hard, involved or complicated, elaborate, having many parts. ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output:

The @@adenomatous polyposis coli (APC) tumour##-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The adenomatous polyposis coli (APC) tumour-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin. Useful knowledge : ||| adenomatous polyposis coli (APC) definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. ||| tumour-suppressor protein definition: Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development. ||| Wnt signalling pathway definition: A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, and the vertebrate INT gene. The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. ||| complex definition: Hard, involved or complicated, elaborate, having many parts. ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output: [/INST] The @@adenomatous polyposis coli (APC) tumour##-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin.

The @@adenomatous polyposis coli (APC) tumour##-suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta (GSK-3beta), axin/conductin and betacatenin.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Complex formation induces the rapid degradation of betacatenin. Useful knowledge : ||| Complex formation definition: The aggregation, arrangement and bonding together of a set of components to form a TORC1 complex. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218] ||| induces definition: The act of bringing about something. ||| degradation definition: None ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output:

Complex formation induces the rapid degradation of betacatenin.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Complex formation induces the rapid degradation of betacatenin. Useful knowledge : ||| Complex formation definition: The aggregation, arrangement and bonding together of a set of components to form a TORC1 complex. [GO_REF:0000079, GOC:kmv, GOC:TermGenie, PMID:21952218] ||| induces definition: The act of bringing about something. ||| degradation definition: None ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| Output: [/INST] Complex formation induces the rapid degradation of betacatenin.

Complex formation induces the rapid degradation of betacatenin.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In colon carcinoma cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]). Useful knowledge : ||| colon carcinoma definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. ||| cells definition: The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary. ||| loss definition: A gradual decline in amount or activity. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| accumulation definition: A state characterized by the gradual increase in entities or substances. ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| nucleus definition: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| binds definition: The action of attracting something and forming a bond with it. ||| activates definition: To cause something to start or to stimulate activity. ||| Tcf-4 transcription factor definition: A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder. ||| reviewed definition: An article or book published after examination of published material on a subject. It may be comprehensive to various degrees and the time range of material scrutinized may be broad or narrow, but the reviews most often desired are reviews of the current literature. The textual material examined may be equally broad and can encompass, in medicine specifically, clinical material as well as experimental research or case reports. State-of-the-art reviews tend to address more current matters. A review of the literature must be differentiated from HISTORICAL ARTICLE on the same subject, but a review of historical literature is also within the scope of this publication type. ||| Output:

In @@colon carcinoma## cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]).

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In colon carcinoma cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]). Useful knowledge : ||| colon carcinoma definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. ||| cells definition: The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary. ||| loss definition: A gradual decline in amount or activity. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| accumulation definition: A state characterized by the gradual increase in entities or substances. ||| betacatenin definition: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS. ||| nucleus definition: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| binds definition: The action of attracting something and forming a bond with it. ||| activates definition: To cause something to start or to stimulate activity. ||| Tcf-4 transcription factor definition: A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder. ||| reviewed definition: An article or book published after examination of published material on a subject. It may be comprehensive to various degrees and the time range of material scrutinized may be broad or narrow, but the reviews most often desired are reviews of the current literature. The textual material examined may be equally broad and can encompass, in medicine specifically, clinical material as well as experimental research or case reports. State-of-the-art reviews tend to address more current matters. A review of the literature must be differentiated from HISTORICAL ARTICLE on the same subject, but a review of historical literature is also within the scope of this publication type. ||| Output: [/INST] In @@colon carcinoma## cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]).

In @@colon carcinoma## cells, loss of APC leads to the accumulation of betacatenin in the nucleus, where it binds to and activates the Tcf-4 transcription factor (reviewed in [1] [2]).

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Here, we report the identification and genomic structure of APC homologues. Useful knowledge : ||| identification definition: A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others. ||| genomic structure definition: The structural elements that comprise a gene or transcription unit. Gene structures include the transcription initiation site, the protein coding sequences, intervening sequences, and the transcription termination or polyadenylation sites as well as the regulatory elements (enhancers, silencers, and the promoter) that lie outside the boundaries of the transcribed unit. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| homologues definition: A gene from one species which corresponds to a gene in another species and that is related via a common ancestral species. These genes retain a similar sequence and function. ||| Output:

Here, we report the identification and genomic structure of APC homologues.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Here, we report the identification and genomic structure of APC homologues. Useful knowledge : ||| identification definition: A process by which an individual unconsciously endeavors to pattern himself after another. This process is also important in the development of the personality, particularly the superego or conscience, which is modeled largely on the behavior of adult significant others. ||| genomic structure definition: The structural elements that comprise a gene or transcription unit. Gene structures include the transcription initiation site, the protein coding sequences, intervening sequences, and the transcription termination or polyadenylation sites as well as the regulatory elements (enhancers, silencers, and the promoter) that lie outside the boundaries of the transcribed unit. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| homologues definition: A gene from one species which corresponds to a gene in another species and that is related via a common ancestral species. These genes retain a similar sequence and function. ||| Output: [/INST] Here, we report the identification and genomic structure of APC homologues.

Here, we report the identification and genomic structure of APC homologues.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin. Useful knowledge : ||| Mammalian definition: Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| domain structure definition: The components and their relationship and manner of arrangement in constituting a whole. ||| analyzed definition: Examination and interpretation; the process of identifying an issue to be understood and addressed, modelling the issue, investigating the model results, interpreting the results, and possibly making a recommendation. The concept also refers to the examination and study of a whole in terms of the parts composing it. ||| SAMP definition: None ||| binding definition: The action of attracting something and forming a bond with it. ||| conductin definition: This gene is involved in signal transduction and plays a role in development. ||| Output:

Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin. Useful knowledge : ||| Mammalian definition: Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| domain structure definition: The components and their relationship and manner of arrangement in constituting a whole. ||| analyzed definition: Examination and interpretation; the process of identifying an issue to be understood and addressed, modelling the issue, investigating the model results, interpreting the results, and possibly making a recommendation. The concept also refers to the examination and study of a whole in terms of the parts composing it. ||| SAMP definition: None ||| binding definition: The action of attracting something and forming a bond with it. ||| conductin definition: This gene is involved in signal transduction and plays a role in development. ||| Output: [/INST] Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin.

Mammalian APC2, which closely resembles APC in overall domain structure, was functionally analyzed and shown to contain two SAMP domains, both of which are required for binding to conductin.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- colon carcinoma cells. Useful knowledge : ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| regulates definition: A rule or order issued by an authority stating what may or may not be done or how something must be done. ||| formation definition: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. [GOC:curators, ISBN:0198547684] ||| active definition: Exerting influence or producing an effect. ||| betacatenin-Tcf definition: A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974] ||| complexes definition: A molecular entity formed by loose association involving two or more component molecular entities. The bonding between the components is normally weaker than in a covalent bond. ||| transient transcriptional activation assays definition: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| colon carcinoma definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. ||| cells definition: The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary. ||| Output:

Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- @@colon carcinoma## cells.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- colon carcinoma cells. Useful knowledge : ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| regulates definition: A rule or order issued by an authority stating what may or may not be done or how something must be done. ||| formation definition: The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. [GOC:curators, ISBN:0198547684] ||| active definition: Exerting influence or producing an effect. ||| betacatenin-Tcf definition: A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974] ||| complexes definition: A molecular entity formed by loose association involving two or more component molecular entities. The bonding between the components is normally weaker than in a covalent bond. ||| transient transcriptional activation assays definition: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes. ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| colon carcinoma definition: A malignant epithelial neoplasm that arises from the colon and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. ||| cells definition: The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary. ||| Output: [/INST] Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- @@colon carcinoma## cells.

Like APC, APC2 regulates the formation of active betacatenin-Tcf complexes, as demonstrated using transient transcriptional activation assays in APC -/- @@colon carcinoma## cells.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Human APC2 maps to chromosome 19p13. Useful knowledge : ||| Human definition: Members of the species Homo sapiens. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| maps definition: A usually 2-dimensional diagrammatic representation of an object or area. ||| chromosome 19p13 definition: A chromosome band present on 19p ||| Output:

Human APC2 maps to chromosome 19p13.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Human APC2 maps to chromosome 19p13. Useful knowledge : ||| Human definition: Members of the species Homo sapiens. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| maps definition: A usually 2-dimensional diagrammatic representation of an object or area. ||| chromosome 19p13 definition: A chromosome band present on 19p ||| Output: [/INST] Human APC2 maps to chromosome 19p13.

Human APC2 maps to chromosome 19p13.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 3. Useful knowledge : ||| Output:

3.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 3. Useful knowledge : ||| Output: [/INST] 3.

3.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: APC and APC2 may therefore have comparable functions in development and cancer. Useful knowledge : ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| functions definition: The normal action performed by a structure or device. ||| development definition: None ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| Output:

APC and APC2 may therefore have comparable functions in development and @@cancer##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: APC and APC2 may therefore have comparable functions in development and cancer. Useful knowledge : ||| APC definition: A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors. ||| APC2 definition: This gene is involved in signal transduction and cell cycle regulation. ||| functions definition: The normal action performed by a structure or device. ||| development definition: None ||| cancer definition: A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. ||| Output: [/INST] APC and APC2 may therefore have comparable functions in development and @@cancer##.

APC and APC2 may therefore have comparable functions in development and @@cancer##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Familial deficiency of the seventh component of complement associated with recurrent bacteremic infections due to Neisseria. Useful knowledge : ||| Familial deficiency definition: Familial LCAT (lecithin-cholesterol acyltransferase) deficiency (FLD) is a form of lecithin-cholesterol acyltransferase deficiency (LCAT; see this term) characterized clinically by corneal opacities, hemolytic anemia, and renal failure, and biochemically by severely decreased HDL cholesterol and complete deficiency of the LCAT enzyme. ||| complement definition: The complement system is a complex system of serum proteins that interact in a cascade. Many of the early components are serine proteases that activate each other sequentially. This complement system consists of three separate activation triggers: (1) Ab binding to a cell surface, (2) formation of immune complexes, and (3) a carbohydrate component of a microbe's cell membrane. Along with this triggers, there are also two sets of mechanisms. Both of these mechanisms, classical pathway and alternative or properdin pathway, make MAC (Membrane Attack Complex), which can lyse and destroy the cell. ||| associated with definition: Joined in some kind of relationship. ||| recurrent definition: Applied to a sign, symptom, or other manifestation that occurs multiple times at usually irregular intervals. The occurences are separated by an interval in which the sign, symptom, or manifestation is not present. [] ||| bacteremic infections definition: Infections by bacteria, general or unspecified. ||| Neisseria definition: A genus of gram-negative, aerobic, coccoid bacteria whose organisms are part of the normal flora of the oropharynx, nasopharynx, and genitourinary tract. Some species are primary pathogens for humans. ||| Output:

@@Familial deficiency of the seventh component of complement## associated with recurrent @@bacteremic infections due to Neisseria##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Familial deficiency of the seventh component of complement associated with recurrent bacteremic infections due to Neisseria. Useful knowledge : ||| Familial deficiency definition: Familial LCAT (lecithin-cholesterol acyltransferase) deficiency (FLD) is a form of lecithin-cholesterol acyltransferase deficiency (LCAT; see this term) characterized clinically by corneal opacities, hemolytic anemia, and renal failure, and biochemically by severely decreased HDL cholesterol and complete deficiency of the LCAT enzyme. ||| complement definition: The complement system is a complex system of serum proteins that interact in a cascade. Many of the early components are serine proteases that activate each other sequentially. This complement system consists of three separate activation triggers: (1) Ab binding to a cell surface, (2) formation of immune complexes, and (3) a carbohydrate component of a microbe's cell membrane. Along with this triggers, there are also two sets of mechanisms. Both of these mechanisms, classical pathway and alternative or properdin pathway, make MAC (Membrane Attack Complex), which can lyse and destroy the cell. ||| associated with definition: Joined in some kind of relationship. ||| recurrent definition: Applied to a sign, symptom, or other manifestation that occurs multiple times at usually irregular intervals. The occurences are separated by an interval in which the sign, symptom, or manifestation is not present. [] ||| bacteremic infections definition: Infections by bacteria, general or unspecified. ||| Neisseria definition: A genus of gram-negative, aerobic, coccoid bacteria whose organisms are part of the normal flora of the oropharynx, nasopharynx, and genitourinary tract. Some species are primary pathogens for humans. ||| Output: [/INST] @@Familial deficiency of the seventh component of complement## associated with recurrent @@bacteremic infections due to Neisseria##.

@@Familial deficiency of the seventh component of complement## associated with recurrent @@bacteremic infections due to Neisseria##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The serum of a 29-year old woman with a recent episode of disseminated gonococcal infection and a history of meningococcal meningitis and arthritis as a child was found to lack serum hemolytic complement activity. Useful knowledge : ||| serum definition: The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins. ||| woman definition: Human females as cultural, psychological, sociological, political, and economic entities. ||| episode definition: A noteworthy happening that is distinctive in a series of related events. ||| disseminated definition: To scatter widely; spread. ||| gonococcal infection definition: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879. ||| history definition: Record and study of past events. ||| meningococcal meningitis definition: A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8) ||| arthritis definition: Acute or chronic inflammation of JOINTS. ||| child definition: A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. ||| serum hemolytic complement activity definition: A screening assay for circulating COMPLEMENT PROTEINS. Diluted SERUM samples are added to antibody-coated ERYTHROCYTES and the percentage of cell lysis is measured. The values are expressed by the so called CH50, in HEMOLYTIC COMPLEMENT units per milliliter, which is the dilution of serum required to lyse 50 percent of the erythrocytes in the assay. ||| Output:

The serum of a 29-year old woman with a recent episode of @@disseminated gonococcal infection## and a history of @@meningococcal meningitis## and @@arthritis## as a child was found to lack serum hemolytic complement activity.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The serum of a 29-year old woman with a recent episode of disseminated gonococcal infection and a history of meningococcal meningitis and arthritis as a child was found to lack serum hemolytic complement activity. Useful knowledge : ||| serum definition: The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins. ||| woman definition: Human females as cultural, psychological, sociological, political, and economic entities. ||| episode definition: A noteworthy happening that is distinctive in a series of related events. ||| disseminated definition: To scatter widely; spread. ||| gonococcal infection definition: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879. ||| history definition: Record and study of past events. ||| meningococcal meningitis definition: A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8) ||| arthritis definition: Acute or chronic inflammation of JOINTS. ||| child definition: A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. ||| serum hemolytic complement activity definition: A screening assay for circulating COMPLEMENT PROTEINS. Diluted SERUM samples are added to antibody-coated ERYTHROCYTES and the percentage of cell lysis is measured. The values are expressed by the so called CH50, in HEMOLYTIC COMPLEMENT units per milliliter, which is the dilution of serum required to lyse 50 percent of the erythrocytes in the assay. ||| Output: [/INST] The serum of a 29-year old woman with a recent episode of @@disseminated gonococcal infection## and a history of @@meningococcal meningitis## and @@arthritis## as a child was found to lack serum hemolytic complement activity.

The serum of a 29-year old woman with a recent episode of @@disseminated gonococcal infection## and a history of @@meningococcal meningitis## and @@arthritis## as a child was found to lack serum hemolytic complement activity.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The seventh component of complement (C7) was not detected by functional or immunochemical assays, whereas other components were normal by hemolytic and immunochemical assessment. Useful knowledge : ||| C7 definition: None ||| functional definition: None ||| immunochemical assays definition: The determination of the amount of islet cell antibody present in a sample. ||| components definition: None ||| hemolytic definition: None ||| Output:

The seventh component of complement (C7) was not detected by functional or immunochemical assays, whereas other components were normal by hemolytic and immunochemical assessment.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The seventh component of complement (C7) was not detected by functional or immunochemical assays, whereas other components were normal by hemolytic and immunochemical assessment. Useful knowledge : ||| C7 definition: None ||| functional definition: None ||| immunochemical assays definition: The determination of the amount of islet cell antibody present in a sample. ||| components definition: None ||| hemolytic definition: None ||| Output: [/INST] The seventh component of complement (C7) was not detected by functional or immunochemical assays, whereas other components were normal by hemolytic and immunochemical assessment.

The seventh component of complement (C7) was not detected by functional or immunochemical assays, whereas other components were normal by hemolytic and immunochemical assessment.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Her fresh serum lacked complement-mediated bactericidal activity against Neisseria gonorrhoeae, but the addition of fresh normal serum or purified C7 restored bactericidal activity as well as hemolytic activity. Useful knowledge : ||| fresh definition: Not previously used. ||| serum definition: The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins. ||| Neisseria gonorrhoeae definition: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA. ||| fresh definition: Not previously used. ||| purified definition: The process of removing impurities. ||| C7 definition: None ||| bactericidal activity definition: None ||| hemolytic activity definition: Disruption of the integrity of the erythrocyte membrane causing release of hemoglobin. ||| Output:

Her fresh serum lacked complement-mediated bactericidal activity against Neisseria gonorrhoeae, but the addition of fresh normal serum or purified C7 restored bactericidal activity as well as hemolytic activity.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Her fresh serum lacked complement-mediated bactericidal activity against Neisseria gonorrhoeae, but the addition of fresh normal serum or purified C7 restored bactericidal activity as well as hemolytic activity. Useful knowledge : ||| fresh definition: Not previously used. ||| serum definition: The clear portion of BLOOD that is left after BLOOD COAGULATION to remove BLOOD CELLS and clotting proteins. ||| Neisseria gonorrhoeae definition: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA. ||| fresh definition: Not previously used. ||| purified definition: The process of removing impurities. ||| C7 definition: None ||| bactericidal activity definition: None ||| hemolytic activity definition: Disruption of the integrity of the erythrocyte membrane causing release of hemoglobin. ||| Output: [/INST] Her fresh serum lacked complement-mediated bactericidal activity against Neisseria gonorrhoeae, but the addition of fresh normal serum or purified C7 restored bactericidal activity as well as hemolytic activity.

Her fresh serum lacked complement-mediated bactericidal activity against Neisseria gonorrhoeae, but the addition of fresh normal serum or purified C7 restored bactericidal activity as well as hemolytic activity.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The absence of functional C7 activity could not be accounted for on the basis of an inhibitor. Useful knowledge : ||| absence definition: Not existing in a specified place at a specified time. ||| functional definition: None ||| C7 activity definition: Body movements of a human or an animal as a behavioral phenomenon. ||| inhibitor definition: A class of substances that binds to and inhibits the function or activity of a target. ||| Output:

The @@absence of functional C7## activity could not be accounted for on the basis of an inhibitor.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The absence of functional C7 activity could not be accounted for on the basis of an inhibitor. Useful knowledge : ||| absence definition: Not existing in a specified place at a specified time. ||| functional definition: None ||| C7 activity definition: Body movements of a human or an animal as a behavioral phenomenon. ||| inhibitor definition: A class of substances that binds to and inhibits the function or activity of a target. ||| Output: [/INST] The @@absence of functional C7## activity could not be accounted for on the basis of an inhibitor.

The @@absence of functional C7## activity could not be accounted for on the basis of an inhibitor.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Opsonization and generation of chemotactic activity functioned normally. Useful knowledge : ||| Opsonization definition: The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149] ||| generation definition: A single step in the line of descent from a common ancestor. ||| chemotactic activity definition: Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult. ||| Output:

Opsonization and generation of chemotactic activity functioned normally.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Opsonization and generation of chemotactic activity functioned normally. Useful knowledge : ||| Opsonization definition: The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149] ||| generation definition: A single step in the line of descent from a common ancestor. ||| chemotactic activity definition: Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult. ||| Output: [/INST] Opsonization and generation of chemotactic activity functioned normally.

Opsonization and generation of chemotactic activity functioned normally.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Complete absence of C7 was also found in one sibling who had the clinical syndrome of meningococcal meningitis and arthritis as a child and in this siblings clinically well eight-year-old son. Useful knowledge : ||| Complete definition: To possess every necessary or normal part or component or step; having come or been brought to a conclusion. ||| absence definition: Not existing in a specified place at a specified time. ||| C7 definition: None ||| sibling definition: Interactions and relationships between sisters and/or brothers. The concept also applies to animal studies. ||| clinical syndrome definition: None ||| meningococcal meningitis definition: A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8) ||| arthritis definition: Acute or chronic inflammation of JOINTS. ||| child definition: A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. ||| siblings definition: Persons or animals having at least one parent in common. (American College Dictionary, 3d ed) ||| clinically definition: Relating to the examination and treatment of patients dependent on direct observation. The term may also refer to the institution (clinic) providing this activity. ||| Output:

@@Complete absence of C7## was also found in one sibling who had the clinical syndrome of @@meningococcal meningitis## and @@arthritis## as a child and in this siblings clinically well eight-year-old son.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Complete absence of C7 was also found in one sibling who had the clinical syndrome of meningococcal meningitis and arthritis as a child and in this siblings clinically well eight-year-old son. Useful knowledge : ||| Complete definition: To possess every necessary or normal part or component or step; having come or been brought to a conclusion. ||| absence definition: Not existing in a specified place at a specified time. ||| C7 definition: None ||| sibling definition: Interactions and relationships between sisters and/or brothers. The concept also applies to animal studies. ||| clinical syndrome definition: None ||| meningococcal meningitis definition: A fulminant infection of the meninges and subarachnoid fluid by the bacterium NEISSERIA MENINGITIDIS, producing diffuse inflammation and peri-meningeal venous thromboses. Clinical manifestations include FEVER, nuchal rigidity, SEIZURES, severe HEADACHE, petechial rash, stupor, focal neurologic deficits, HYDROCEPHALUS, and COMA. The organism is usually transmitted via nasopharyngeal secretions and is a leading cause of meningitis in children and young adults. Organisms from Neisseria meningitidis serogroups A, B, C, Y, and W-135 have been reported to cause meningitis. (From Adams et al., Principles of Neurology, 6th ed, pp689-701; Curr Opin Pediatr 1998 Feb;10(1):13-8) ||| arthritis definition: Acute or chronic inflammation of JOINTS. ||| child definition: A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. ||| siblings definition: Persons or animals having at least one parent in common. (American College Dictionary, 3d ed) ||| clinically definition: Relating to the examination and treatment of patients dependent on direct observation. The term may also refer to the institution (clinic) providing this activity. ||| Output: [/INST] @@Complete absence of C7## was also found in one sibling who had the clinical syndrome of @@meningococcal meningitis## and @@arthritis## as a child and in this siblings clinically well eight-year-old son.

@@Complete absence of C7## was also found in one sibling who had the clinical syndrome of @@meningococcal meningitis## and @@arthritis## as a child and in this siblings clinically well eight-year-old son.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HLA histocompatibility typing of the family members did not demonstrate evidence for genetic linkage of C7 deficiency with the major histocompatibility loci. Useful knowledge : ||| HLA histocompatibility typing definition: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed) ||| family members definition: Any of the individuals who are descended from a common progenitor, related by marriage or other legal tie, or by a feeling of closeness. ||| evidence definition: Knowledge on which to base belief. ||| genetic linkage definition: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME. ||| C7 deficiency definition: None ||| histocompatibility loci definition: Genetic loci responsible for the encoding of histocompatibility antigens other than those encoded by the MAJOR HISTOCOMPATIBILITY COMPLEX. The antigens encoded by these genes are often responsible for graft rejection in cases where histocompatibility has been established by standard tests. The location of some of these loci on the X and Y chromosomes explains why grafts from males to females may be rejected while grafts from females to males are accepted. In the mouse roughly 30 minor histocompatibility loci have been recognized, comprising more than 500 genes. ||| Output:

HLA histocompatibility typing of the family members did not demonstrate evidence for genetic linkage of @@C7 deficiency## with the major histocompatibility loci.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HLA histocompatibility typing of the family members did not demonstrate evidence for genetic linkage of C7 deficiency with the major histocompatibility loci. Useful knowledge : ||| HLA histocompatibility typing definition: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed) ||| family members definition: Any of the individuals who are descended from a common progenitor, related by marriage or other legal tie, or by a feeling of closeness. ||| evidence definition: Knowledge on which to base belief. ||| genetic linkage definition: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME. ||| C7 deficiency definition: None ||| histocompatibility loci definition: Genetic loci responsible for the encoding of histocompatibility antigens other than those encoded by the MAJOR HISTOCOMPATIBILITY COMPLEX. The antigens encoded by these genes are often responsible for graft rejection in cases where histocompatibility has been established by standard tests. The location of some of these loci on the X and Y chromosomes explains why grafts from males to females may be rejected while grafts from females to males are accepted. In the mouse roughly 30 minor histocompatibility loci have been recognized, comprising more than 500 genes. ||| Output: [/INST] HLA histocompatibility typing of the family members did not demonstrate evidence for genetic linkage of @@C7 deficiency## with the major histocompatibility loci.

HLA histocompatibility typing of the family members did not demonstrate evidence for genetic linkage of @@C7 deficiency## with the major histocompatibility loci.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This report represents the first cases of C7 deficiency associated with infectious complications and suggests that bactericidal activity may be important in host defense against bacteremic neisseria infections. Useful knowledge : ||| report definition: Detailed account or statement or formal record of the proceedings of a meeting or session. May also document status or progress of an activity or research project. ||| cases definition: None ||| C7 deficiency definition: None ||| associated with definition: Joined in some kind of relationship. ||| infectious complications definition: The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION. ||| bactericidal activity definition: None ||| host defense definition: Host Defenses against pathology include physical barriers to pathogens, immediate nonspecific and constitutive (innate) defenses, specific inducible immune responses, metabolic and physiologic homeostatic mechanisms, detoxification, repair processes, and healing mechanisms. ||| bacteremic neisseria infections definition: Infections with bacteria of the family NEISSERIACEAE. ||| Output:

This report represents the first cases of @@C7 deficiency## associated with infectious complications and suggests that bactericidal activity may be important in host defense against @@bacteremic neisseria infections##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: This report represents the first cases of C7 deficiency associated with infectious complications and suggests that bactericidal activity may be important in host defense against bacteremic neisseria infections. Useful knowledge : ||| report definition: Detailed account or statement or formal record of the proceedings of a meeting or session. May also document status or progress of an activity or research project. ||| cases definition: None ||| C7 deficiency definition: None ||| associated with definition: Joined in some kind of relationship. ||| infectious complications definition: The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION. ||| bactericidal activity definition: None ||| host defense definition: Host Defenses against pathology include physical barriers to pathogens, immediate nonspecific and constitutive (innate) defenses, specific inducible immune responses, metabolic and physiologic homeostatic mechanisms, detoxification, repair processes, and healing mechanisms. ||| bacteremic neisseria infections definition: Infections with bacteria of the family NEISSERIACEAE. ||| Output: [/INST] This report represents the first cases of @@C7 deficiency## associated with infectious complications and suggests that bactericidal activity may be important in host defense against @@bacteremic neisseria infections##.

This report represents the first cases of @@C7 deficiency## associated with infectious complications and suggests that bactericidal activity may be important in host defense against @@bacteremic neisseria infections##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: GCH1 mutation in a patient with adult-onset oromandibular dystonia. Useful knowledge : ||| GCH1 definition: None ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| patient definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| adult-onset definition: A progressive neurodegenerative disorder affecting upper motor neurons, characterized by progressive muscle weakness. ||| oromandibular dystonia definition: A kind of focal dystonia characterized by forceful contractions of the face, jaw, and/or tongue causing difficulty in opening and closing the mouth and often affecting chewing and speech. [HPO:probinson] ||| Output:

GCH1 mutation in a patient with adult-onset @@oromandibular dystonia##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: GCH1 mutation in a patient with adult-onset oromandibular dystonia. Useful knowledge : ||| GCH1 definition: None ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| patient definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| adult-onset definition: A progressive neurodegenerative disorder affecting upper motor neurons, characterized by progressive muscle weakness. ||| oromandibular dystonia definition: A kind of focal dystonia characterized by forceful contractions of the face, jaw, and/or tongue causing difficulty in opening and closing the mouth and often affecting chewing and speech. [HPO:probinson] ||| Output: [/INST] GCH1 mutation in a patient with adult-onset @@oromandibular dystonia##.

GCH1 mutation in a patient with adult-onset @@oromandibular dystonia##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The authors report a mutation in exon 5 of GCH1 in a patient with adult-onset oromandibular dystonia and no obvious family history of dystonia. Useful knowledge : ||| authors definition: The writer of a book, article, or other text. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| exon 5 definition: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA. ||| GCH1 definition: None ||| patient definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| adult-onset definition: A progressive neurodegenerative disorder affecting upper motor neurons, characterized by progressive muscle weakness. ||| oromandibular dystonia definition: A kind of focal dystonia characterized by forceful contractions of the face, jaw, and/or tongue causing difficulty in opening and closing the mouth and often affecting chewing and speech. [HPO:probinson] ||| family history definition: A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. ||| dystonia definition: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77) ||| Output:

The authors report a mutation in exon 5 of GCH1 in a patient with adult-onset @@oromandibular dystonia## and no obvious family history of @@dystonia##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The authors report a mutation in exon 5 of GCH1 in a patient with adult-onset oromandibular dystonia and no obvious family history of dystonia. Useful knowledge : ||| authors definition: The writer of a book, article, or other text. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| exon 5 definition: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA. ||| GCH1 definition: None ||| patient definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| adult-onset definition: A progressive neurodegenerative disorder affecting upper motor neurons, characterized by progressive muscle weakness. ||| oromandibular dystonia definition: A kind of focal dystonia characterized by forceful contractions of the face, jaw, and/or tongue causing difficulty in opening and closing the mouth and often affecting chewing and speech. [HPO:probinson] ||| family history definition: A record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions. ||| dystonia definition: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77) ||| Output: [/INST] The authors report a mutation in exon 5 of GCH1 in a patient with adult-onset @@oromandibular dystonia## and no obvious family history of @@dystonia##.

The authors report a mutation in exon 5 of GCH1 in a patient with adult-onset @@oromandibular dystonia## and no obvious family history of @@dystonia##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The patient responded positively to treatment with L-dopa. Useful knowledge : ||| patient definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| positively definition: Involving advantage or good. ||| treatment definition: Used with diseases for therapeutic interventions except drug therapy, diet therapy, radiotherapy, and surgery, for which specific subheadings exist. The concept is also used for articles and books dealing with multiple therapies. ||| L-dopa definition: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. ||| Output:

The patient responded positively to treatment with L-dopa.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The patient responded positively to treatment with L-dopa. Useful knowledge : ||| patient definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| positively definition: Involving advantage or good. ||| treatment definition: Used with diseases for therapeutic interventions except drug therapy, diet therapy, radiotherapy, and surgery, for which specific subheadings exist. The concept is also used for articles and books dealing with multiple therapies. ||| L-dopa definition: The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. ||| Output: [/INST] The patient responded positively to treatment with L-dopa.

The patient responded positively to treatment with L-dopa.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: These findings demonstrate that GCH1 mutations must be considered even in patients with dystonic symptoms not typical of dopa-responsive dystonia. Useful knowledge : ||| findings definition: None ||| GCH1 definition: None ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| dystonic symptoms definition: Subjective evidence of disease perceived by the patient. ||| dopa-responsive dystonia definition: None ||| Output:

These findings demonstrate that GCH1 mutations must be considered even in patients with @@dystonic## symptoms not typical of @@dopa-responsive dystonia##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: These findings demonstrate that GCH1 mutations must be considered even in patients with dystonic symptoms not typical of dopa-responsive dystonia. Useful knowledge : ||| findings definition: None ||| GCH1 definition: None ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| dystonic symptoms definition: Subjective evidence of disease perceived by the patient. ||| dopa-responsive dystonia definition: None ||| Output: [/INST] These findings demonstrate that GCH1 mutations must be considered even in patients with @@dystonic## symptoms not typical of @@dopa-responsive dystonia##.

These findings demonstrate that GCH1 mutations must be considered even in patients with @@dystonic## symptoms not typical of @@dopa-responsive dystonia##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells. Useful knowledge : ||| hereditary hemochromatosis protein definition: Hereditary hemochromatosis protein (348 aa, ~40 kDa) is encoded by the human HFE gene. This protein plays a role in the regulation of transport of iron. ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| regulates definition: A rule or order issued by an authority stating what may or may not be done or how something must be done. ||| HeLa cells definition: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. ||| Output:

The @@hereditary hemochromatosis## protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells. Useful knowledge : ||| hereditary hemochromatosis protein definition: Hereditary hemochromatosis protein (348 aa, ~40 kDa) is encoded by the human HFE gene. This protein plays a role in the regulation of transport of iron. ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| regulates definition: A rule or order issued by an authority stating what may or may not be done or how something must be done. ||| HeLa cells definition: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. ||| Output: [/INST] The @@hereditary hemochromatosis## protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells.

The @@hereditary hemochromatosis## protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis (Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R. J., Ellis, M. C., Fullan, A., Hinton, L. M., Jones, N. L., Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D. B., Mapa, F. A., McClelland, E., Meyer, N. C., Mintier, G. A., Moeller, N., Moore, T., Morikang, E., Prasss, C. E ., Quintana, L., Starnes, S. M ., Schatzman, R. C ., Brunke, K. J ., Drayna, D. T., Risch, N. J ., Bacon, B. R ., and Wolff, R. R . Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| protein product definition: The end result of a manufacturing process; anything that is produced. ||| gene mutated definition: Human ATM wild-type allele is located within 11q22-q23 and is approximately 143 kb in length. This allele, which encodes serine-protein kinase ATM protein, plays a critical role in cell cycle checkpoint signaling pathways required for cellular response to DNA damage and maintenance of genomic stability. Defects in the ATM gene cause ataxia telangiectasia and contribute to certain cancers such as T-cell acute lymphoblastic leukemia, B-cell chronic lymphocytic leukemia and B-cell non-Hodgkin lymphomas. ||| autosomal recessive disease hereditary hemochromatosis definition: A form of rare hereditary hemochromatosis, a group of diseases characterized by excessive tissue iron deposition of genetic origin. Type 4 is less rare than the other rare forms of hereditary hemochromatosis. The disease is phenotypically heterogeneous with two sub-types. Ferroportin disease form A is the usual form and is generally asymptomatic with no tissue damage and further complications. Ferroportin disease form B is rarer and resembles hemochromatosis type 1, but can affect children. Ferroportin disease is due to mutations in the SLC40A1 gene located on chromosome 2, which encodes for ferroportin (FPN), an iron exporter negatively regulated by the hepcidin hormone. Transmission is autosomal dominant. ||| Feder definition: Fish eye disease (FED) is a form of genetic LCAT (lecithin-cholesterol acyltransferase) deficiency (see this term) characterized clinically by corneal opacifications, and biochemically by significantly reduced HDL cholesterol and partial LCAT enzyme deficiency. ||| Basava definition: Human TBXT wild-type allele is located in the vicinity of 6q27 and is approximately 11 kb in length. This allele, which encodes T-box transcription factor T protein, plays a role in the regulation of transcription during mesoderm formation and differentiation. Gene duplication is associated with familial chordoma. ||| A. definition: The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum. ||| Fullan definition: Containing as much or as many as is possible or normal. ||| A. definition: The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum. ||| Jones definition: None ||| Kimmel definition: The mission of the Kimmel Cancer Center is to make transformational discoveries of the cellular and molecular biology of the malignant process and the individual's and society's response to it; effectively translate the latest research discoveries and clinical trials to provide the highest quality of care to all patients including those of diverse ethnic and racial populations; and provide expert and humanitarian care to cancer patients, their families, and those at risk. It received its NCI designation in 1996. ||| Mapa definition: None ||| E. definition: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. ||| Prasss definition: A disease of infants due to group 2 phage type 17 staphylococci that produce an epidermolytic exotoxin. Superficial fine vesicles and bullae form and rupture easily, resulting in loss of large sheets of epidermis. ||| Quintana definition: None ||| Bacon definition: A chemotherapy regimen consisting of bleomycin, doxorubicin, lomustine, mechlorethamine, and vincristine that may be used in the treatment of head and neck cancer. ||| Wolff definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| Output:

HFE is the protein product of the gene mutated in the @@autosomal recessive disease## @@hereditary hemochromatosis## (Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R. J., Ellis, M. C., Fullan, A., Hinton, L. M., Jones, N. L., Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D. B., Mapa, F. A., McClelland, E., Meyer, N. C., Mintier, G. A., Moeller, N., Moore, T., Morikang, E., Prasss, C. E ., Quintana, L., Starnes, S. M ., Schatzman, R. C ., Brunke, K. J ., Drayna, D. T., Risch, N. J ., Bacon, B. R ., and Wolff, R. R .

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HFE is the protein product of the gene mutated in the autosomal recessive disease hereditary hemochromatosis (Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R. J., Ellis, M. C., Fullan, A., Hinton, L. M., Jones, N. L., Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D. B., Mapa, F. A., McClelland, E., Meyer, N. C., Mintier, G. A., Moeller, N., Moore, T., Morikang, E., Prasss, C. E ., Quintana, L., Starnes, S. M ., Schatzman, R. C ., Brunke, K. J ., Drayna, D. T., Risch, N. J ., Bacon, B. R ., and Wolff, R. R . Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| protein product definition: The end result of a manufacturing process; anything that is produced. ||| gene mutated definition: Human ATM wild-type allele is located within 11q22-q23 and is approximately 143 kb in length. This allele, which encodes serine-protein kinase ATM protein, plays a critical role in cell cycle checkpoint signaling pathways required for cellular response to DNA damage and maintenance of genomic stability. Defects in the ATM gene cause ataxia telangiectasia and contribute to certain cancers such as T-cell acute lymphoblastic leukemia, B-cell chronic lymphocytic leukemia and B-cell non-Hodgkin lymphomas. ||| autosomal recessive disease hereditary hemochromatosis definition: A form of rare hereditary hemochromatosis, a group of diseases characterized by excessive tissue iron deposition of genetic origin. Type 4 is less rare than the other rare forms of hereditary hemochromatosis. The disease is phenotypically heterogeneous with two sub-types. Ferroportin disease form A is the usual form and is generally asymptomatic with no tissue damage and further complications. Ferroportin disease form B is rarer and resembles hemochromatosis type 1, but can affect children. Ferroportin disease is due to mutations in the SLC40A1 gene located on chromosome 2, which encodes for ferroportin (FPN), an iron exporter negatively regulated by the hepcidin hormone. Transmission is autosomal dominant. ||| Feder definition: Fish eye disease (FED) is a form of genetic LCAT (lecithin-cholesterol acyltransferase) deficiency (see this term) characterized clinically by corneal opacifications, and biochemically by significantly reduced HDL cholesterol and partial LCAT enzyme deficiency. ||| Basava definition: Human TBXT wild-type allele is located in the vicinity of 6q27 and is approximately 11 kb in length. This allele, which encodes T-box transcription factor T protein, plays a role in the regulation of transcription during mesoderm formation and differentiation. Gene duplication is associated with familial chordoma. ||| A. definition: The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum. ||| Fullan definition: Containing as much or as many as is possible or normal. ||| A. definition: The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum. ||| Jones definition: None ||| Kimmel definition: The mission of the Kimmel Cancer Center is to make transformational discoveries of the cellular and molecular biology of the malignant process and the individual's and society's response to it; effectively translate the latest research discoveries and clinical trials to provide the highest quality of care to all patients including those of diverse ethnic and racial populations; and provide expert and humanitarian care to cancer patients, their families, and those at risk. It received its NCI designation in 1996. ||| Mapa definition: None ||| E. definition: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. ||| Prasss definition: A disease of infants due to group 2 phage type 17 staphylococci that produce an epidermolytic exotoxin. Superficial fine vesicles and bullae form and rupture easily, resulting in loss of large sheets of epidermis. ||| Quintana definition: None ||| Bacon definition: A chemotherapy regimen consisting of bleomycin, doxorubicin, lomustine, mechlorethamine, and vincristine that may be used in the treatment of head and neck cancer. ||| Wolff definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| Output: [/INST] HFE is the protein product of the gene mutated in the @@autosomal recessive disease## @@hereditary hemochromatosis## (Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R. J., Ellis, M. C., Fullan, A., Hinton, L. M., Jones, N. L., Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D. B., Mapa, F. A., McClelland, E., Meyer, N. C., Mintier, G. A., Moeller, N., Moore, T., Morikang, E., Prasss, C. E ., Quintana, L., Starnes, S. M ., Schatzman, R. C ., Brunke, K. J ., Drayna, D. T., Risch, N. J ., Bacon, B. R ., and Wolff, R. R .

HFE is the protein product of the gene mutated in the @@autosomal recessive disease## @@hereditary hemochromatosis## (Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R. J., Ellis, M. C., Fullan, A., Hinton, L. M., Jones, N. L., Kimmel, B. E., Kronmal, G. S., Lauer, P., Lee, V. K., Loeb, D. B., Mapa, F. A., McClelland, E., Meyer, N. C., Mintier, G. A., Moeller, N., Moore, T., Morikang, E., Prasss, C. E ., Quintana, L., Starnes, S. M ., Schatzman, R. C ., Brunke, K. J ., Drayna, D. T., Risch, N. J ., Bacon, B. R ., and Wolff, R. R .

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: (1996) Nat. Useful knowledge : ||| Output:

(1996) Nat.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: (1996) Nat. Useful knowledge : ||| Output: [/INST] (1996) Nat.

(1996) Nat.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Genet. Useful knowledge : ||| Genet definition: None ||| Output:

Genet.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Genet. Useful knowledge : ||| Genet definition: None ||| Output: [/INST] Genet.

Genet.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 13, 399-408). Useful knowledge : ||| Output:

13, 399-408).

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 13, 399-408). Useful knowledge : ||| Output: [/INST] 13, 399-408).

13, 399-408).

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: At the cell surface, HFE complexes with transferrin receptor (TfR), increasing the dissociation constant of transferrin (Tf) for its receptor 10-fold (Gross, C. N ., Irrinki, A., Feder, J. N ., and Enns, C. A . Useful knowledge : ||| cell surface definition: The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| complexes definition: A molecular entity formed by loose association involving two or more component molecular entities. The bonding between the components is normally weaker than in a covalent bond. ||| transferrin receptor definition: Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released. ||| TfR definition: Transferrin receptor protein 1 (760 aa, ~85 kDa) is encoded by the human TFRC gene. This protein plays a role in the transport of iron into cells. ||| increasing definition: None ||| Tf definition: This gene is involved in the blood coagulation process by initiating blood coagulation cascades. ||| receptor definition: A protein located on the cell surface, or in the cytoplasm, that binds to a specific signaling factor, such as a hormone, antigen, or neurotransmitter, causing a conformational and functional change in the receptor molecule. The ligand-bound receptor then alters its interaction with target molecules, which leads to changes in cellular physiology through modification of the activity of one or more signal transduction pathways. ||| Feder definition: Fish eye disease (FED) is a form of genetic LCAT (lecithin-cholesterol acyltransferase) deficiency (see this term) characterized clinically by corneal opacifications, and biochemically by significantly reduced HDL cholesterol and partial LCAT enzyme deficiency. ||| Output:

At the cell surface, HFE complexes with transferrin receptor (TfR), increasing the dissociation constant of transferrin (Tf) for its receptor 10-fold (Gross, C. N ., Irrinki, A., Feder, J. N ., and Enns, C. A .

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: At the cell surface, HFE complexes with transferrin receptor (TfR), increasing the dissociation constant of transferrin (Tf) for its receptor 10-fold (Gross, C. N ., Irrinki, A., Feder, J. N ., and Enns, C. A . Useful knowledge : ||| cell surface definition: The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| complexes definition: A molecular entity formed by loose association involving two or more component molecular entities. The bonding between the components is normally weaker than in a covalent bond. ||| transferrin receptor definition: Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released. ||| TfR definition: Transferrin receptor protein 1 (760 aa, ~85 kDa) is encoded by the human TFRC gene. This protein plays a role in the transport of iron into cells. ||| increasing definition: None ||| Tf definition: This gene is involved in the blood coagulation process by initiating blood coagulation cascades. ||| receptor definition: A protein located on the cell surface, or in the cytoplasm, that binds to a specific signaling factor, such as a hormone, antigen, or neurotransmitter, causing a conformational and functional change in the receptor molecule. The ligand-bound receptor then alters its interaction with target molecules, which leads to changes in cellular physiology through modification of the activity of one or more signal transduction pathways. ||| Feder definition: Fish eye disease (FED) is a form of genetic LCAT (lecithin-cholesterol acyltransferase) deficiency (see this term) characterized clinically by corneal opacifications, and biochemically by significantly reduced HDL cholesterol and partial LCAT enzyme deficiency. ||| Output: [/INST] At the cell surface, HFE complexes with transferrin receptor (TfR), increasing the dissociation constant of transferrin (Tf) for its receptor 10-fold (Gross, C. N ., Irrinki, A., Feder, J. N ., and Enns, C. A .

At the cell surface, HFE complexes with transferrin receptor (TfR), increasing the dissociation constant of transferrin (Tf) for its receptor 10-fold (Gross, C. N ., Irrinki, A., Feder, J. N ., and Enns, C. A .

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: (1998) J. Biol. Useful knowledge : ||| Output:

(1998) J. Biol.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: (1998) J. Biol. Useful knowledge : ||| Output: [/INST] (1998) J. Biol.

(1998) J. Biol.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Chem. Useful knowledge : ||| Chem definition: A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen. ||| Output:

Chem.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Chem. Useful knowledge : ||| Chem definition: A laboratory test designed for the quantification of an organic or inorganic chemical within a biological specimen. ||| Output: [/INST] Chem.

Chem.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 273, 22068-22074; Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebron, J. Useful knowledge : ||| Output:

273, 22068-22074; Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebron, J.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: 273, 22068-22074; Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebron, J. Useful knowledge : ||| Output: [/INST] 273, 22068-22074; Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebron, J.

273, 22068-22074; Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebron, J.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., and Schatzman, R. C. (1998) Proc. Useful knowledge : ||| A. definition: The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum. ||| Watson definition: None ||| Sigal definition: The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS). ||| E. definition: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. ||| Output:

A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., and Schatzman, R. C. (1998) Proc.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., and Schatzman, R. C. (1998) Proc. Useful knowledge : ||| A. definition: The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum. ||| Watson definition: None ||| Sigal definition: The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS). ||| E. definition: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc. ||| Output: [/INST] A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., and Schatzman, R. C. (1998) Proc.

A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., and Schatzman, R. C. (1998) Proc.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Natl . Useful knowledge : ||| Natl definition: Cathepsin L1 (333 aa, ~38 kDa) is encoded by the human CTSL gene. This protein is involved in both proteolysis and immunity. ||| Output:

Natl .

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Natl . Useful knowledge : ||| Natl definition: Cathepsin L1 (333 aa, ~38 kDa) is encoded by the human CTSL gene. This protein is involved in both proteolysis and immunity. ||| Output: [/INST] Natl .

Natl .

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Acad. Useful knowledge : ||| Acad definition: An autosomal recessive disorder of fatty acid oxidation, and branched chain amino acids (AMINO ACIDS, BRANCHED-CHAIN); LYSINE; and CHOLINE catabolism, that is due to defects in either subunit of ELECTRON TRANSFER FLAVOPROTEIN or its dehydrogenase, electron transfer flavoprotein-ubiquinone oxidoreductase (EC 1.5.5.1). ||| Output:

Acad.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Acad. Useful knowledge : ||| Acad definition: An autosomal recessive disorder of fatty acid oxidation, and branched chain amino acids (AMINO ACIDS, BRANCHED-CHAIN); LYSINE; and CHOLINE catabolism, that is due to defects in either subunit of ELECTRON TRANSFER FLAVOPROTEIN or its dehydrogenase, electron transfer flavoprotein-ubiquinone oxidoreductase (EC 1.5.5.1). ||| Output: [/INST] Acad.

Acad.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Sci. Useful knowledge : ||| Output:

Sci.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Sci. Useful knowledge : ||| Output: [/INST] Sci.

Sci.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: U S A 95, 1472-1477). Useful knowledge : ||| U S A 95 definition: A country in NORTH AMERICA between CANADA and MEXICO. ||| Output:

U S A 95, 1472-1477).

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: U S A 95, 1472-1477). Useful knowledge : ||| U S A 95 definition: A country in NORTH AMERICA between CANADA and MEXICO. ||| Output: [/INST] U S A 95, 1472-1477).

U S A 95, 1472-1477).

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HFE does not remain at the cell surface, but traffics with TfR to Tf-positive internal compartments (Gross et al., 1998). Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| cell surface definition: The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] ||| TfR definition: Transferrin receptor protein 1 (760 aa, ~85 kDa) is encoded by the human TFRC gene. This protein plays a role in the transport of iron into cells. ||| internal compartments definition: <p>A named tag set for metadata used to populate a security category label field that "segments" an IT resource per policy by indicating that access and use is restricted to members of a defined community or project. (HL7 Healthcare Privacy and Security Classification System)</p><i>Usage Note:</i>This is the healthcare analog to the US Intelligence Community's concept of a Special Access Program. Compartment codes may be used in as a field value in an initiator's clearance to indicate permission to access and use an IT Resource with a security label having the same compartment value in security category label field.<p>Map: Aligns with ISO 2382-8 definition of Compartment - "A division of data into isolated blocks with separate security controls for the purpose of reducing risk."</p> ||| Output:

HFE does not remain at the cell surface, but traffics with TfR to Tf-positive internal compartments (Gross et al., 1998).

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HFE does not remain at the cell surface, but traffics with TfR to Tf-positive internal compartments (Gross et al., 1998). Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| cell surface definition: The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] ||| TfR definition: Transferrin receptor protein 1 (760 aa, ~85 kDa) is encoded by the human TFRC gene. This protein plays a role in the transport of iron into cells. ||| internal compartments definition: <p>A named tag set for metadata used to populate a security category label field that "segments" an IT resource per policy by indicating that access and use is restricted to members of a defined community or project. (HL7 Healthcare Privacy and Security Classification System)</p><i>Usage Note:</i>This is the healthcare analog to the US Intelligence Community's concept of a Special Access Program. Compartment codes may be used in as a field value in an initiator's clearance to indicate permission to access and use an IT Resource with a security label having the same compartment value in security category label field.<p>Map: Aligns with ISO 2382-8 definition of Compartment - "A division of data into isolated blocks with separate security controls for the purpose of reducing risk."</p> ||| Output: [/INST] HFE does not remain at the cell surface, but traffics with TfR to Tf-positive internal compartments (Gross et al., 1998).

HFE does not remain at the cell surface, but traffics with TfR to Tf-positive internal compartments (Gross et al., 1998).

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Using a HeLa cell line in which the expression of HFE is controlled by tetracycline, we show that the expression of HFE reduces 55Fe uptake from Tf by 33% but does not affect the endocytic or exocytic rates of TfR cycling. Useful knowledge : ||| HeLa cell line definition: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. ||| expression definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| controlled definition: The act of directing or determining; regulation or maintenance of a function or action; a relation of constraint of one entity (thing or person or group) by another. ||| tetracycline definition: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. ||| expression definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| Tf definition: This gene is involved in the blood coagulation process by initiating blood coagulation cascades. ||| endocytic definition: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis. ||| exocytic rates definition: The cellular processes that contribute to exocytosis. [Wikipedia:Exocytosis] ||| TfR definition: Transferrin receptor protein 1 (760 aa, ~85 kDa) is encoded by the human TFRC gene. This protein plays a role in the transport of iron into cells. ||| cycling definition: The use of a bicycle for transportation or recreation. It does not include the use of a bicycle in studying the body's response to physical exertion (BICYCLE ERGOMETRY TEST see EXERCISE TEST). ||| Output:

Using a HeLa cell line in which the expression of HFE is controlled by tetracycline, we show that the expression of HFE reduces 55Fe uptake from Tf by 33% but does not affect the endocytic or exocytic rates of TfR cycling.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Using a HeLa cell line in which the expression of HFE is controlled by tetracycline, we show that the expression of HFE reduces 55Fe uptake from Tf by 33% but does not affect the endocytic or exocytic rates of TfR cycling. Useful knowledge : ||| HeLa cell line definition: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. ||| expression definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| controlled definition: The act of directing or determining; regulation or maintenance of a function or action; a relation of constraint of one entity (thing or person or group) by another. ||| tetracycline definition: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. ||| expression definition: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION. ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| Tf definition: This gene is involved in the blood coagulation process by initiating blood coagulation cascades. ||| endocytic definition: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis. ||| exocytic rates definition: The cellular processes that contribute to exocytosis. [Wikipedia:Exocytosis] ||| TfR definition: Transferrin receptor protein 1 (760 aa, ~85 kDa) is encoded by the human TFRC gene. This protein plays a role in the transport of iron into cells. ||| cycling definition: The use of a bicycle for transportation or recreation. It does not include the use of a bicycle in studying the body's response to physical exertion (BICYCLE ERGOMETRY TEST see EXERCISE TEST). ||| Output: [/INST] Using a HeLa cell line in which the expression of HFE is controlled by tetracycline, we show that the expression of HFE reduces 55Fe uptake from Tf by 33% but does not affect the endocytic or exocytic rates of TfR cycling.

Using a HeLa cell line in which the expression of HFE is controlled by tetracycline, we show that the expression of HFE reduces 55Fe uptake from Tf by 33% but does not affect the endocytic or exocytic rates of TfR cycling.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Therefore, HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| reduce definition: Made less in size or amount or degree. ||| cellular acquisition definition: The process by which something is acquired or obtained. ||| iron definition: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. ||| Tf definition: This gene is involved in the blood coagulation process by initiating blood coagulation cascades. ||| endocytic compartments definition: <p>A named tag set for metadata used to populate a security category label field that "segments" an IT resource per policy by indicating that access and use is restricted to members of a defined community or project. (HL7 Healthcare Privacy and Security Classification System)</p><i>Usage Note:</i>This is the healthcare analog to the US Intelligence Community's concept of a Special Access Program. Compartment codes may be used in as a field value in an initiator's clearance to indicate permission to access and use an IT Resource with a security label having the same compartment value in security category label field.<p>Map: Aligns with ISO 2382-8 definition of Compartment - "A division of data into isolated blocks with separate security controls for the purpose of reducing risk."</p> ||| Output:

Therefore, HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Therefore, HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| reduce definition: Made less in size or amount or degree. ||| cellular acquisition definition: The process by which something is acquired or obtained. ||| iron definition: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. ||| Tf definition: This gene is involved in the blood coagulation process by initiating blood coagulation cascades. ||| endocytic compartments definition: <p>A named tag set for metadata used to populate a security category label field that "segments" an IT resource per policy by indicating that access and use is restricted to members of a defined community or project. (HL7 Healthcare Privacy and Security Classification System)</p><i>Usage Note:</i>This is the healthcare analog to the US Intelligence Community's concept of a Special Access Program. Compartment codes may be used in as a field value in an initiator's clearance to indicate permission to access and use an IT Resource with a security label having the same compartment value in security category label field.<p>Map: Aligns with ISO 2382-8 definition of Compartment - "A division of data into isolated blocks with separate security controls for the purpose of reducing risk."</p> ||| Output: [/INST] Therefore, HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments.

Therefore, HFE appears to reduce cellular acquisition of iron from Tf within endocytic compartments.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| reduces definition: Made less in size or amount or degree. ||| iron uptake definition: The absorption by a tissue of some substance, food material, mineral, etc., and its permanent or temporary retention. ||| Tf definition: This gene is involved in the blood coagulation process by initiating blood coagulation cascades. ||| Fe-nitrilotriacetic acid definition: A derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.) ||| Output:

HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered. Useful knowledge : ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| reduces definition: Made less in size or amount or degree. ||| iron uptake definition: The absorption by a tissue of some substance, food material, mineral, etc., and its permanent or temporary retention. ||| Tf definition: This gene is involved in the blood coagulation process by initiating blood coagulation cascades. ||| Fe-nitrilotriacetic acid definition: A derivative of acetic acid, N(CH2COOH)3. It is a complexing (sequestering) agent that forms stable complexes with Zn2+. (From Miall's Dictionary of Chemistry, 5th ed.) ||| Output: [/INST] HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered.

HFE specifically reduces iron uptake from Tf, as non-Tf-mediated iron uptake from Fe-nitrilotriacetic acid is not altered.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf-mediated pathway of iron uptake. Useful knowledge : ||| results definition: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition. ||| decreased definition: A subjective response indicating that something is or has decreased. ||| ferritin definition: Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types. ||| levels definition: A position on a scale measuring intensity, quality, or amount. ||| HeLa cell system definition: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| Tf-mediated pathway definition: The series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah] ||| iron uptake definition: The absorption by a tissue of some substance, food material, mineral, etc., and its permanent or temporary retention. ||| Output:

These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf-mediated pathway of iron uptake.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf-mediated pathway of iron uptake. Useful knowledge : ||| results definition: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition. ||| decreased definition: A subjective response indicating that something is or has decreased. ||| ferritin definition: Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types. ||| levels definition: A position on a scale measuring intensity, quality, or amount. ||| HeLa cell system definition: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| Tf-mediated pathway definition: The series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah] ||| iron uptake definition: The absorption by a tissue of some substance, food material, mineral, etc., and its permanent or temporary retention. ||| Output: [/INST] These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf-mediated pathway of iron uptake.

These results explain the decreased ferritin levels seen in our HeLa cell system and demonstrate the specific control of HFE over the Tf-mediated pathway of iron uptake.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver, pancreas, heart, and spleen that are iron loaded in hereditary hemochromatotic individuals lacking functional HFE. Useful knowledge : ||| results definition: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition. ||| cellular iron homeostasis definition: Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. [GOC:ai, GOC:mah] ||| organs definition: A unique macroscopic (gross) anatomic structure that performs specific functions. It is composed of various tissues. An organ is part of an anatomic system or a body region. Representative examples include the heart, lung, liver, spleen, and uterus. ||| liver definition: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. ||| pancreas definition: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM. ||| heart definition: The hollow, muscular organ that maintains the circulation of the blood. ||| spleen definition: An encapsulated lymphatic organ through which venous blood filters. ||| iron definition: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. ||| loaded definition: To fill or to place an object onto or into a structure or conveyence; in computer terms, to copy data into memory. ||| hereditary hemochromatotic definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| individuals definition: Persons as individuals (e.g., ABORTION APPLICANTS) or as members of a group (e.g., HISPANIC AMERICANS). It is not used for members of the various professions (e.g., PHYSICIANS) or occupations (e.g., LIBRARIANS) for which OCCUPATIONAL GROUPS is available. ||| functional definition: None ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| Output:

These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver, pancreas, heart, and spleen that are iron loaded in @@hereditary hemochromatotic## individuals lacking functional HFE.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver, pancreas, heart, and spleen that are iron loaded in hereditary hemochromatotic individuals lacking functional HFE. Useful knowledge : ||| results definition: The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition. ||| cellular iron homeostasis definition: Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. [GOC:ai, GOC:mah] ||| organs definition: A unique macroscopic (gross) anatomic structure that performs specific functions. It is composed of various tissues. An organ is part of an anatomic system or a body region. Representative examples include the heart, lung, liver, spleen, and uterus. ||| liver definition: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. ||| pancreas definition: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM. ||| heart definition: The hollow, muscular organ that maintains the circulation of the blood. ||| spleen definition: An encapsulated lymphatic organ through which venous blood filters. ||| iron definition: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. ||| loaded definition: To fill or to place an object onto or into a structure or conveyence; in computer terms, to copy data into memory. ||| hereditary hemochromatotic definition: An inherited metabolic disorder characterized by iron accumulation in the tissues. ||| individuals definition: Persons as individuals (e.g., ABORTION APPLICANTS) or as members of a group (e.g., HISPANIC AMERICANS). It is not used for members of the various professions (e.g., PHYSICIANS) or occupations (e.g., LIBRARIANS) for which OCCUPATIONAL GROUPS is available. ||| functional definition: None ||| HFE definition: This gene plays a role in the modulation of iron transport. ||| Output: [/INST] These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver, pancreas, heart, and spleen that are iron loaded in @@hereditary hemochromatotic## individuals lacking functional HFE.

These results also have implications for the understanding of cellular iron homeostasis in organs such as the liver, pancreas, heart, and spleen that are iron loaded in @@hereditary hemochromatotic## individuals lacking functional HFE.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population. Useful knowledge : ||| Mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| haplotype definition: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX. ||| studies definition: None ||| familial Mediterranean definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| fever definition: An abnormal elevation of body temperature, usually as a result of a pathologic process. ||| relationships definition: A state of connectedness between people, objects, or events; to be associated or connected with something. ||| evidence definition: Knowledge on which to base belief. ||| carrier definition: An individual who carries an inheritable genetic mutation without manifestation of the associated condition. ||| frequency definition: None ||| reduced definition: Made less in size or amount or degree. ||| penetrance definition: The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed) ||| Ashkenazi definition: Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe. ||| Output:

Mutation and haplotype studies of @@familial Mediterranean fever## reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population. Useful knowledge : ||| Mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| haplotype definition: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX. ||| studies definition: None ||| familial Mediterranean definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| fever definition: An abnormal elevation of body temperature, usually as a result of a pathologic process. ||| relationships definition: A state of connectedness between people, objects, or events; to be associated or connected with something. ||| evidence definition: Knowledge on which to base belief. ||| carrier definition: An individual who carries an inheritable genetic mutation without manifestation of the associated condition. ||| frequency definition: None ||| reduced definition: Made less in size or amount or degree. ||| penetrance definition: The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed) ||| Ashkenazi definition: Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe. ||| Output: [/INST] Mutation and haplotype studies of @@familial Mediterranean fever## reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population.

Mutation and haplotype studies of @@familial Mediterranean fever## reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever with serositis or synovitis. Useful knowledge : ||| Familial Mediterranean fever definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| FMF definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| recessive disorder definition: An inherited disorder manifested only when two copies of a mutated gene are present. ||| characterized definition: The act of describing distinctive characteristics or essential features. ||| episodes definition: A noteworthy happening that is distinctive in a series of related events. ||| fever definition: An abnormal elevation of body temperature, usually as a result of a pathologic process. ||| serositis definition: Inflammation of a serous membrane. ||| synovitis definition: Inflammation of the SYNOVIAL MEMBRANE. ||| Output:

@@Familial Mediterranean fever## (@@FMF##) is a @@recessive disorder## characterized by episodes of fever with @@serositis## or @@synovitis##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever with serositis or synovitis. Useful knowledge : ||| Familial Mediterranean fever definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| FMF definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| recessive disorder definition: An inherited disorder manifested only when two copies of a mutated gene are present. ||| characterized definition: The act of describing distinctive characteristics or essential features. ||| episodes definition: A noteworthy happening that is distinctive in a series of related events. ||| fever definition: An abnormal elevation of body temperature, usually as a result of a pathologic process. ||| serositis definition: Inflammation of a serous membrane. ||| synovitis definition: Inflammation of the SYNOVIAL MEMBRANE. ||| Output: [/INST] @@Familial Mediterranean fever## (@@FMF##) is a @@recessive disorder## characterized by episodes of fever with @@serositis## or @@synovitis##.

@@Familial Mediterranean fever## (@@FMF##) is a @@recessive disorder## characterized by episodes of fever with @@serositis## or @@synovitis##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The FMF gene (MEFV) was cloned recently, and four missense mutations were identified. Useful knowledge : ||| FMF gene definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| MEFV definition: None ||| cloned definition: A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed) ||| missense mutations definition: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed) ||| identified definition: The procedure of having an identity established. ||| Output:

The @@FMF## gene (MEFV) was cloned recently, and four missense mutations were identified.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The FMF gene (MEFV) was cloned recently, and four missense mutations were identified. Useful knowledge : ||| FMF gene definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| MEFV definition: None ||| cloned definition: A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed) ||| missense mutations definition: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed) ||| identified definition: The procedure of having an identity established. ||| Output: [/INST] The @@FMF## gene (MEFV) was cloned recently, and four missense mutations were identified.

The @@FMF## gene (MEFV) was cloned recently, and four missense mutations were identified.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Here we present data from non-Ashkenazi Jewish and Arab patients in whom we had not originally found mutations and from a new, more ethnically diverse panel. Useful knowledge : ||| data definition: A collection or single item of factual information, derived from measurement or research, from which conclusions may be drawn. ||| Jewish definition: The monotheistic religion of the Jews based on the teachings of the Hebrew Scriptures (Torah). ||| Arab definition: Members of a Semitic people inhabiting the Arabian peninsula or other countries of the Middle East and North Africa. The term may be used with reference to ancient, medieval, or modern ethnic or cultural groups. (From Random House Unabridged Dictionary, 2d ed) ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| panel definition: Any number of entities (members) considered as a unit. ||| Output:

Here we present data from non-Ashkenazi Jewish and Arab patients in whom we had not originally found mutations and from a new, more ethnically diverse panel.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Here we present data from non-Ashkenazi Jewish and Arab patients in whom we had not originally found mutations and from a new, more ethnically diverse panel. Useful knowledge : ||| data definition: A collection or single item of factual information, derived from measurement or research, from which conclusions may be drawn. ||| Jewish definition: The monotheistic religion of the Jews based on the teachings of the Hebrew Scriptures (Torah). ||| Arab definition: Members of a Semitic people inhabiting the Arabian peninsula or other countries of the Middle East and North Africa. The term may be used with reference to ancient, medieval, or modern ethnic or cultural groups. (From Random House Unabridged Dictionary, 2d ed) ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| panel definition: Any number of entities (members) considered as a unit. ||| Output: [/INST] Here we present data from non-Ashkenazi Jewish and Arab patients in whom we had not originally found mutations and from a new, more ethnically diverse panel.

Here we present data from non-Ashkenazi Jewish and Arab patients in whom we had not originally found mutations and from a new, more ethnically diverse panel.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Among 90 symptomatic mutation-positive individuals, 11 mutations accounted for 79% of carrier chromosomes. Useful knowledge : ||| symptomatic definition: Exhibiting the symptoms of a particular disease. ||| mutation-positive definition: A finding of Lynch syndrome in which one is identified as a carrier or obligate carrier of a pathogenic mutation(s) in one of several DNA mismatch repair genes, including MLH1, MSH2/EPCAM, MSH6 or PMS2. ||| individuals definition: Persons as individuals (e.g., ABORTION APPLICANTS) or as members of a group (e.g., HISPANIC AMERICANS). It is not used for members of the various professions (e.g., PHYSICIANS) or occupations (e.g., LIBRARIANS) for which OCCUPATIONAL GROUPS is available. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| carrier chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| Output:

Among 90 symptomatic mutation-positive individuals, 11 mutations accounted for 79% of carrier chromosomes.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Among 90 symptomatic mutation-positive individuals, 11 mutations accounted for 79% of carrier chromosomes. Useful knowledge : ||| symptomatic definition: Exhibiting the symptoms of a particular disease. ||| mutation-positive definition: A finding of Lynch syndrome in which one is identified as a carrier or obligate carrier of a pathogenic mutation(s) in one of several DNA mismatch repair genes, including MLH1, MSH2/EPCAM, MSH6 or PMS2. ||| individuals definition: Persons as individuals (e.g., ABORTION APPLICANTS) or as members of a group (e.g., HISPANIC AMERICANS). It is not used for members of the various professions (e.g., PHYSICIANS) or occupations (e.g., LIBRARIANS) for which OCCUPATIONAL GROUPS is available. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| carrier chromosomes definition: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) ||| Output: [/INST] Among 90 symptomatic mutation-positive individuals, 11 mutations accounted for 79% of carrier chromosomes.

Among 90 symptomatic mutation-positive individuals, 11 mutations accounted for 79% of carrier chromosomes.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Of the two mutations that are novel, one alters the same residue (680) as a previously known mutation, and the other (P369S) is located in exon 3. Useful knowledge : ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| novel definition: Having no previous example or precedent or parallel; of a kind not seen before. ||| residue definition: A single unit within a polymer; a recognizable molecular fragment embedded in a larger molecule. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| exon 3 definition: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA. ||| Output:

Of the two mutations that are novel, one alters the same residue (680) as a previously known mutation, and the other (P369S) is located in exon 3.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Of the two mutations that are novel, one alters the same residue (680) as a previously known mutation, and the other (P369S) is located in exon 3. Useful knowledge : ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| novel definition: Having no previous example or precedent or parallel; of a kind not seen before. ||| residue definition: A single unit within a polymer; a recognizable molecular fragment embedded in a larger molecule. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| exon 3 definition: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA. ||| Output: [/INST] Of the two mutations that are novel, one alters the same residue (680) as a previously known mutation, and the other (P369S) is located in exon 3.

Of the two mutations that are novel, one alters the same residue (680) as a previously known mutation, and the other (P369S) is located in exon 3.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Consistent with another recent report, the E148Q mutation was observed in patients of several ethnicities and on multiple microsatellite haplotypes, but haplotype data indicate an ancestral relationships between non-Jewish Italian and Ashkenazi Jewish patients with FMF and other affected populations. Useful knowledge : ||| Consistent with definition: Marked by a reasonable or logical relation of parts and holding together as a harmonious or credible whole. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| ethnicities definition: A group of people with a common cultural heritage that sets them apart from others in a variety of social relationships. ||| microsatellite haplotypes definition: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs). ||| haplotype definition: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX. ||| data definition: A collection or single item of factual information, derived from measurement or research, from which conclusions may be drawn. ||| ancestral definition: A person's descent or lineage, from a person or from a population. ||| relationships definition: A state of connectedness between people, objects, or events; to be associated or connected with something. ||| Italian definition: A romance language spoken as the official language of Italy and San Marino. ||| Ashkenazi definition: Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe. ||| Jewish definition: The monotheistic religion of the Jews based on the teachings of the Hebrew Scriptures (Torah). ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| FMF definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| affected definition: To be influenced by or changed. ||| populations definition: The total number of individuals inhabiting a particular region or area. ||| Output:

Consistent with another recent report, the E148Q mutation was observed in patients of several ethnicities and on multiple microsatellite haplotypes, but haplotype data indicate an ancestral relationships between non-Jewish Italian and Ashkenazi Jewish patients with @@FMF## and other affected populations.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Consistent with another recent report, the E148Q mutation was observed in patients of several ethnicities and on multiple microsatellite haplotypes, but haplotype data indicate an ancestral relationships between non-Jewish Italian and Ashkenazi Jewish patients with FMF and other affected populations. Useful knowledge : ||| Consistent with definition: Marked by a reasonable or logical relation of parts and holding together as a harmonious or credible whole. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| ethnicities definition: A group of people with a common cultural heritage that sets them apart from others in a variety of social relationships. ||| microsatellite haplotypes definition: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs). ||| haplotype definition: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX. ||| data definition: A collection or single item of factual information, derived from measurement or research, from which conclusions may be drawn. ||| ancestral definition: A person's descent or lineage, from a person or from a population. ||| relationships definition: A state of connectedness between people, objects, or events; to be associated or connected with something. ||| Italian definition: A romance language spoken as the official language of Italy and San Marino. ||| Ashkenazi definition: Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe. ||| Jewish definition: The monotheistic religion of the Jews based on the teachings of the Hebrew Scriptures (Torah). ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| FMF definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| affected definition: To be influenced by or changed. ||| populations definition: The total number of individuals inhabiting a particular region or area. ||| Output: [/INST] Consistent with another recent report, the E148Q mutation was observed in patients of several ethnicities and on multiple microsatellite haplotypes, but haplotype data indicate an ancestral relationships between non-Jewish Italian and Ashkenazi Jewish patients with @@FMF## and other affected populations.

Consistent with another recent report, the E148Q mutation was observed in patients of several ethnicities and on multiple microsatellite haplotypes, but haplotype data indicate an ancestral relationships between non-Jewish Italian and Ashkenazi Jewish patients with @@FMF## and other affected populations.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Among approximately 200 anonymous Ashkenazi Jewish DNA samples, the MEFV carrier frequency was 21%, with E148Q the most common mutation. Useful knowledge : ||| Ashkenazi definition: Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe. ||| Jewish definition: The monotheistic religion of the Jews based on the teachings of the Hebrew Scriptures (Torah). ||| MEFV definition: None ||| carrier definition: An individual who carries an inheritable genetic mutation without manifestation of the associated condition. ||| frequency definition: None ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output:

Among approximately 200 anonymous Ashkenazi Jewish DNA samples, the MEFV carrier frequency was 21%, with E148Q the most common mutation.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Among approximately 200 anonymous Ashkenazi Jewish DNA samples, the MEFV carrier frequency was 21%, with E148Q the most common mutation. Useful knowledge : ||| Ashkenazi definition: Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe. ||| Jewish definition: The monotheistic religion of the Jews based on the teachings of the Hebrew Scriptures (Torah). ||| MEFV definition: None ||| carrier definition: An individual who carries an inheritable genetic mutation without manifestation of the associated condition. ||| frequency definition: None ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output: [/INST] Among approximately 200 anonymous Ashkenazi Jewish DNA samples, the MEFV carrier frequency was 21%, with E148Q the most common mutation.

Among approximately 200 anonymous Ashkenazi Jewish DNA samples, the MEFV carrier frequency was 21%, with E148Q the most common mutation.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Several lines of evidence indicate reduced penetrance among Ashkenazi Jews, especially for E148Q, P369S, and K695R. Useful knowledge : ||| evidence definition: Knowledge on which to base belief. ||| reduced definition: Made less in size or amount or degree. ||| penetrance definition: The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed) ||| Ashkenazi definition: Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe. ||| Jews definition: An ethnic group with historical ties to the land of ISRAEL and the religion of JUDAISM. ||| Output:

Several lines of evidence indicate reduced penetrance among Ashkenazi Jews, especially for E148Q, P369S, and K695R.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Several lines of evidence indicate reduced penetrance among Ashkenazi Jews, especially for E148Q, P369S, and K695R. Useful knowledge : ||| evidence definition: Knowledge on which to base belief. ||| reduced definition: Made less in size or amount or degree. ||| penetrance definition: The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed) ||| Ashkenazi definition: Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe. ||| Jews definition: An ethnic group with historical ties to the land of ISRAEL and the religion of JUDAISM. ||| Output: [/INST] Several lines of evidence indicate reduced penetrance among Ashkenazi Jews, especially for E148Q, P369S, and K695R.

Several lines of evidence indicate reduced penetrance among Ashkenazi Jews, especially for E148Q, P369S, and K695R.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Nevertheless, E148Q helps account for recessive inheritance in an Ashkenazi family previously reported as an unusual case of dominantly inherited FMF. Useful knowledge : ||| recessive inheritance definition: None ||| case definition: None ||| inherited definition: Transmitted through genes from parents to offspring. (genome.gov) ||| FMF definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| Output:

Nevertheless, E148Q helps account for recessive inheritance in an Ashkenazi family previously reported as an unusual case of dominantly inherited @@FMF##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Nevertheless, E148Q helps account for recessive inheritance in an Ashkenazi family previously reported as an unusual case of dominantly inherited FMF. Useful knowledge : ||| recessive inheritance definition: None ||| case definition: None ||| inherited definition: Transmitted through genes from parents to offspring. (genome.gov) ||| FMF definition: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene encoding PYRIN result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease also exists with mutations in the same gene. ||| Output: [/INST] Nevertheless, E148Q helps account for recessive inheritance in an Ashkenazi family previously reported as an unusual case of dominantly inherited @@FMF##.

Nevertheless, E148Q helps account for recessive inheritance in an Ashkenazi family previously reported as an unusual case of dominantly inherited @@FMF##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The presence of three frequent MEFV mutations in multiple Mediterranean populations strongly suggests a heterozygote advantage in this geographic region. Useful knowledge : ||| presence definition: None ||| frequent definition: Coming at short intervals or in great quantities. ||| MEFV definition: None ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| multiple definition: An indefinite large quantity that is considered to be greater than several. ||| Mediterranean definition: Denotes a person having origins in any of the countries abutting the Mediterranean Sea, principally those of Europe. ||| populations definition: The total number of individuals inhabiting a particular region or area. ||| heterozygote definition: An individual having different alleles at one or more loci regarding a specific character. ||| geographic region definition: The continents and countries situated on those continents; the UNITED STATES and each of the constituent states arranged by region; CANADA and each of its provinces; AUSTRALIA and each of its states; the major bodies of water and major islands on both hemispheres; and selected major cities. ||| Output:

The presence of three frequent MEFV mutations in multiple Mediterranean populations strongly suggests a heterozygote advantage in this geographic region.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: The presence of three frequent MEFV mutations in multiple Mediterranean populations strongly suggests a heterozygote advantage in this geographic region. Useful knowledge : ||| presence definition: None ||| frequent definition: Coming at short intervals or in great quantities. ||| MEFV definition: None ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| multiple definition: An indefinite large quantity that is considered to be greater than several. ||| Mediterranean definition: Denotes a person having origins in any of the countries abutting the Mediterranean Sea, principally those of Europe. ||| populations definition: The total number of individuals inhabiting a particular region or area. ||| heterozygote definition: An individual having different alleles at one or more loci regarding a specific character. ||| geographic region definition: The continents and countries situated on those continents; the UNITED STATES and each of the constituent states arranged by region; CANADA and each of its provinces; AUSTRALIA and each of its states; the major bodies of water and major islands on both hemispheres; and selected major cities. ||| Output: [/INST] The presence of three frequent MEFV mutations in multiple Mediterranean populations strongly suggests a heterozygote advantage in this geographic region.

The presence of three frequent MEFV mutations in multiple Mediterranean populations strongly suggests a heterozygote advantage in this geographic region.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. Useful knowledge : ||| Autoimmune lymphoproliferative syndrome definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| defective definition: None ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| genotype definition: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. ||| influences definition: The power to have an effect on people, things, or events. ||| penetrance definition: The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed) ||| Output:

@@Autoimmune lymphoproliferative syndrome## with defective Fas: genotype influences penetrance.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Autoimmune lymphoproliferative syndrome with defective Fas: genotype influences penetrance. Useful knowledge : ||| Autoimmune lymphoproliferative syndrome definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| defective definition: None ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| genotype definition: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. ||| influences definition: The power to have an effect on people, things, or events. ||| penetrance definition: The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed) ||| Output: [/INST] @@Autoimmune lymphoproliferative syndrome## with defective Fas: genotype influences penetrance.

@@Autoimmune lymphoproliferative syndrome## with defective Fas: genotype influences penetrance.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance. Useful knowledge : ||| Autoimmune lymphoproliferative syndrome definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| ALPS definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| disorder definition: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. ||| lymphocyte homeostasis definition: The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] ||| immunological tolerance definition: The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc. ||| Output:

@@Autoimmune lymphoproliferative syndrome## (@@ALPS##) is a @@disorder of lymphocyte homeostasis and immunological tolerance##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte homeostasis and immunological tolerance. Useful knowledge : ||| Autoimmune lymphoproliferative syndrome definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| ALPS definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| disorder definition: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. ||| lymphocyte homeostasis definition: The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] ||| immunological tolerance definition: The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc. ||| Output: [/INST] @@Autoimmune lymphoproliferative syndrome## (@@ALPS##) is a @@disorder of lymphocyte homeostasis and immunological tolerance##.

@@Autoimmune lymphoproliferative syndrome## (@@ALPS##) is a @@disorder of lymphocyte homeostasis and immunological tolerance##.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Most patients have a heterozygous mutation in the APT1 gene, which encodes Fas (CD95, APO-1), mediator of an apoptotic pathway crucial to lymphocyte homeostasis. Useful knowledge : ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| heterozygous definition: An individual having different alleles at one or more loci regarding a specific character. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| APT1 gene definition: Antigen peptide transporter 1 (808 aa, ~87 kDa) is encoded by the human TAP1 gene. This protein plays a role in cytoplasmic antigen transport and subsequent presentation by MHC class I molecules. ||| encodes definition: To assign a code to represent data. ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| CD95 definition: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome. ||| APO-1 definition: This gene is involved in the mediation of cellular surface receptors and apoptotic signals. ||| apoptotic pathway definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] ||| lymphocyte homeostasis definition: The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] ||| Output:

Most patients have a heterozygous mutation in the APT1 gene, which encodes Fas (CD95, APO-1), mediator of an apoptotic pathway crucial to lymphocyte homeostasis.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Most patients have a heterozygous mutation in the APT1 gene, which encodes Fas (CD95, APO-1), mediator of an apoptotic pathway crucial to lymphocyte homeostasis. Useful knowledge : ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| heterozygous definition: An individual having different alleles at one or more loci regarding a specific character. ||| mutation definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| APT1 gene definition: Antigen peptide transporter 1 (808 aa, ~87 kDa) is encoded by the human TAP1 gene. This protein plays a role in cytoplasmic antigen transport and subsequent presentation by MHC class I molecules. ||| encodes definition: To assign a code to represent data. ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| CD95 definition: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome. ||| APO-1 definition: This gene is involved in the mediation of cellular surface receptors and apoptotic signals. ||| apoptotic pathway definition: The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119] ||| lymphocyte homeostasis definition: The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] ||| Output: [/INST] Most patients have a heterozygous mutation in the APT1 gene, which encodes Fas (CD95, APO-1), mediator of an apoptotic pathway crucial to lymphocyte homeostasis.

Most patients have a heterozygous mutation in the APT1 gene, which encodes Fas (CD95, APO-1), mediator of an apoptotic pathway crucial to lymphocyte homeostasis.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Of 17 unique APT1 mutations in unrelated ALPS probands, 12 (71%) occurred in exons 7-9, which encode the intracellular portion of Fas. Useful knowledge : ||| APT1 definition: Antigen peptide transporter 1 (808 aa, ~87 kDa) is encoded by the human TAP1 gene. This protein plays a role in cytoplasmic antigen transport and subsequent presentation by MHC class I molecules. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| ALPS definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| probands definition: None ||| exons definition: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA. ||| intracellular portion definition: The organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts. ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| Output:

Of 17 unique APT1 mutations in unrelated @@ALPS## probands, 12 (71%) occurred in exons 7-9, which encode the intracellular portion of Fas.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Of 17 unique APT1 mutations in unrelated ALPS probands, 12 (71%) occurred in exons 7-9, which encode the intracellular portion of Fas. Useful knowledge : ||| APT1 definition: Antigen peptide transporter 1 (808 aa, ~87 kDa) is encoded by the human TAP1 gene. This protein plays a role in cytoplasmic antigen transport and subsequent presentation by MHC class I molecules. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| ALPS definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| probands definition: None ||| exons definition: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA. ||| intracellular portion definition: The organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts. ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| Output: [/INST] Of 17 unique APT1 mutations in unrelated @@ALPS## probands, 12 (71%) occurred in exons 7-9, which encode the intracellular portion of Fas.

Of 17 unique APT1 mutations in unrelated @@ALPS## probands, 12 (71%) occurred in exons 7-9, which encode the intracellular portion of Fas.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In vitro, activated lymphocytes from all 17 patients showed apoptotic defects when exposed to an anti-Fas agonist monoclonal antibody. Useful knowledge : ||| In vitro definition: Studies using excised tissues. ||| activated definition: To cause something to start or to stimulate activity. ||| lymphocytes definition: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| apoptotic defects definition: Pertaining to apoptosis. ||| exposed definition: The act of subjecting someone or something to an influencing experience. ||| monoclonal antibody definition: Antibodies produced by a single clone of cells. ||| Output:

In vitro, activated lymphocytes from all 17 patients showed apoptotic defects when exposed to an anti-Fas agonist monoclonal antibody.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In vitro, activated lymphocytes from all 17 patients showed apoptotic defects when exposed to an anti-Fas agonist monoclonal antibody. Useful knowledge : ||| In vitro definition: Studies using excised tissues. ||| activated definition: To cause something to start or to stimulate activity. ||| lymphocytes definition: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| apoptotic defects definition: Pertaining to apoptosis. ||| exposed definition: The act of subjecting someone or something to an influencing experience. ||| monoclonal antibody definition: Antibodies produced by a single clone of cells. ||| Output: [/INST] In vitro, activated lymphocytes from all 17 patients showed apoptotic defects when exposed to an anti-Fas agonist monoclonal antibody.

In vitro, activated lymphocytes from all 17 patients showed apoptotic defects when exposed to an anti-Fas agonist monoclonal antibody.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Similar defects were found in a Fas-negative cell line transfected with cDNAs bearing each of the mutations. Useful knowledge : ||| defects definition: None ||| transfected definition: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES. ||| cDNAs definition: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output:

Similar defects were found in a Fas-negative cell line transfected with cDNAs bearing each of the mutations.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Similar defects were found in a Fas-negative cell line transfected with cDNAs bearing each of the mutations. Useful knowledge : ||| defects definition: None ||| transfected definition: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES. ||| cDNAs definition: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| Output: [/INST] Similar defects were found in a Fas-negative cell line transfected with cDNAs bearing each of the mutations.

Similar defects were found in a Fas-negative cell line transfected with cDNAs bearing each of the mutations.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In cotransfection experiments, Fas constructs with either intra- or extracellular mutations caused dominant inhibition of apoptosis mediated by wild-type Fas. Useful knowledge : ||| cotransfection experiments definition: A coordinated set of actions and observations designed to generate data, with the ultimate goal of discovery or hypothesis testing. ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| constructs definition: Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected. ||| intra- definition: A prefix indicating a quantity of one trillion, 10E12. ||| extracellular mutations definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] ||| dominant definition: Exercising influence or control. ||| inhibition definition: The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process. ||| apoptosis definition: A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. ||| wild-type definition: A genetic finding indicating that MET gene mutations have not been detected in a sample. ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| Output:

In cotransfection experiments, Fas constructs with either intra- or extracellular mutations caused dominant inhibition of apoptosis mediated by wild-type Fas.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: In cotransfection experiments, Fas constructs with either intra- or extracellular mutations caused dominant inhibition of apoptosis mediated by wild-type Fas. Useful knowledge : ||| cotransfection experiments definition: A coordinated set of actions and observations designed to generate data, with the ultimate goal of discovery or hypothesis testing. ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| constructs definition: Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected. ||| intra- definition: A prefix indicating a quantity of one trillion, 10E12. ||| extracellular mutations definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] ||| dominant definition: Exercising influence or control. ||| inhibition definition: The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process. ||| apoptosis definition: A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. ||| wild-type definition: A genetic finding indicating that MET gene mutations have not been detected in a sample. ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| Output: [/INST] In cotransfection experiments, Fas constructs with either intra- or extracellular mutations caused dominant inhibition of apoptosis mediated by wild-type Fas.

In cotransfection experiments, Fas constructs with either intra- or extracellular mutations caused dominant inhibition of apoptosis mediated by wild-type Fas.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Two missense Fas variants, not restricted to patients with ALPS, were identified. Useful knowledge : ||| missense definition: None ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| variants definition: An alteration or difference from a norm or standard. ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| ALPS definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| identified definition: The procedure of having an identity established. ||| Output:

Two missense Fas variants, not restricted to patients with @@ALPS##, were identified.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Two missense Fas variants, not restricted to patients with ALPS, were identified. Useful knowledge : ||| missense definition: None ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| variants definition: An alteration or difference from a norm or standard. ||| patients definition: Individuals participating in the health care system for the purpose of receiving therapeutic, diagnostic, or preventive procedures. ||| ALPS definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| identified definition: The procedure of having an identity established. ||| Output: [/INST] Two missense Fas variants, not restricted to patients with @@ALPS##, were identified.

Two missense Fas variants, not restricted to patients with @@ALPS##, were identified.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Variant A (-1) T at the Fas signal-sequence cleavage site, which mediates apoptosis less well than wild-type Fas and is partially inhibitory, was present in 13% of African American alleles. Useful knowledge : ||| Variant A definition: An alteration or difference from a norm or standard. ||| apoptosis definition: A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. ||| wild-type definition: A genetic finding indicating that MET gene mutations have not been detected in a sample. ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| inhibitory definition: The interference with or prevention of an action or response even though the stimulus for that action or response is present. ||| African American definition: Denotes a person of African ancestral origins whose family settled in America. ||| alleles definition: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product. ||| Output:

Variant A (-1) T at the Fas signal-sequence cleavage site, which mediates apoptosis less well than wild-type Fas and is partially inhibitory, was present in 13% of African American alleles.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Variant A (-1) T at the Fas signal-sequence cleavage site, which mediates apoptosis less well than wild-type Fas and is partially inhibitory, was present in 13% of African American alleles. Useful knowledge : ||| Variant A definition: An alteration or difference from a norm or standard. ||| apoptosis definition: A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. ||| wild-type definition: A genetic finding indicating that MET gene mutations have not been detected in a sample. ||| Fas definition: A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. ||| inhibitory definition: The interference with or prevention of an action or response even though the stimulus for that action or response is present. ||| African American definition: Denotes a person of African ancestral origins whose family settled in America. ||| alleles definition: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product. ||| Output: [/INST] Variant A (-1) T at the Fas signal-sequence cleavage site, which mediates apoptosis less well than wild-type Fas and is partially inhibitory, was present in 13% of African American alleles.

Variant A (-1) T at the Fas signal-sequence cleavage site, which mediates apoptosis less well than wild-type Fas and is partially inhibitory, was present in 13% of African American alleles.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Among the ALPS-associated Fas mutants, dominant inhibition of apoptosis was much more pronounced in mutants affecting the intracellular, versus extracellular, portion of the Fas receptor. Useful knowledge : ||| ALPS-associated definition: This gene is involved in both protein folding and nitric oxide metabolism. ||| Fas mutants definition: An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). ||| dominant definition: Exercising influence or control. ||| inhibition definition: The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process. ||| apoptosis definition: A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. ||| mutants definition: An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). ||| affecting definition: To be influenced by or changed. ||| intracellular definition: The organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts. ||| extracellular definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] ||| portion definition: One of the portions into which something is regarded as divided and which together constitute a whole. ||| Fas receptor definition: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome. ||| Output:

Among the @@ALPS##-associated Fas mutants, dominant inhibition of apoptosis was much more pronounced in mutants affecting the intracellular, versus extracellular, portion of the Fas receptor.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Among the ALPS-associated Fas mutants, dominant inhibition of apoptosis was much more pronounced in mutants affecting the intracellular, versus extracellular, portion of the Fas receptor. Useful knowledge : ||| ALPS-associated definition: This gene is involved in both protein folding and nitric oxide metabolism. ||| Fas mutants definition: An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). ||| dominant definition: Exercising influence or control. ||| inhibition definition: The interference with or prevention of a behavioral or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process. ||| apoptosis definition: A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. ||| mutants definition: An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). ||| affecting definition: To be influenced by or changed. ||| intracellular definition: The organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts. ||| extracellular definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] ||| portion definition: One of the portions into which something is regarded as divided and which together constitute a whole. ||| Fas receptor definition: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome. ||| Output: [/INST] Among the @@ALPS##-associated Fas mutants, dominant inhibition of apoptosis was much more pronounced in mutants affecting the intracellular, versus extracellular, portion of the Fas receptor.

Among the @@ALPS##-associated Fas mutants, dominant inhibition of apoptosis was much more pronounced in mutants affecting the intracellular, versus extracellular, portion of the Fas receptor.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Mutations causing disruption of the intracellular Fas death domain also showed a higher penetrance of ALPS phenotype features in mutation-bearing relatives. Useful knowledge : ||| Mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| disruption definition: An interruption or interference in continuity. ||| intracellular definition: The organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts. ||| Fas death domain definition: A conserved protein interaction domain of the death domain superfamily that is structurally similar to the DEATH EFFECTOR DOMAIN and CASPASE RECRUITMENT DOMAIN. Death domains bind each other to form oligomers and occur on DEATH DOMAIN RECEPTORS, where they are required for APOPTOSIS signaling and non-apoptotic functions. ||| penetrance definition: The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed) ||| ALPS definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| phenotype definition: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. ||| features definition: Discrete protein structural units that may fold independently of the rest of the protein and have their own functions. ||| Output:

Mutations causing disruption of the intracellular Fas death domain also showed a higher penetrance of @@ALPS## phenotype features in mutation-bearing relatives.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Mutations causing disruption of the intracellular Fas death domain also showed a higher penetrance of ALPS phenotype features in mutation-bearing relatives. Useful knowledge : ||| Mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| disruption definition: An interruption or interference in continuity. ||| intracellular definition: The organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts. ||| Fas death domain definition: A conserved protein interaction domain of the death domain superfamily that is structurally similar to the DEATH EFFECTOR DOMAIN and CASPASE RECRUITMENT DOMAIN. Death domains bind each other to form oligomers and occur on DEATH DOMAIN RECEPTORS, where they are required for APOPTOSIS signaling and non-apoptotic functions. ||| penetrance definition: The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed) ||| ALPS definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| phenotype definition: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. ||| features definition: Discrete protein structural units that may fold independently of the rest of the protein and have their own functions. ||| Output: [/INST] Mutations causing disruption of the intracellular Fas death domain also showed a higher penetrance of @@ALPS## phenotype features in mutation-bearing relatives.

Mutations causing disruption of the intracellular Fas death domain also showed a higher penetrance of @@ALPS## phenotype features in mutation-bearing relatives.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Significant ALPS-related morbidity occurred in 44% of relatives with intracellular mutations, versus 0% of relatives with extracellular mutations. Useful knowledge : ||| relatives definition: A person related by blood or marriage. ||| intracellular mutations definition: The organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts. ||| relatives definition: A person related by blood or marriage. ||| extracellular mutations definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] ||| Output:

Significant @@ALPS##-related morbidity occurred in 44% of relatives with intracellular mutations, versus 0% of relatives with extracellular mutations.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Significant ALPS-related morbidity occurred in 44% of relatives with intracellular mutations, versus 0% of relatives with extracellular mutations. Useful knowledge : ||| relatives definition: A person related by blood or marriage. ||| intracellular mutations definition: The organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts. ||| relatives definition: A person related by blood or marriage. ||| extracellular mutations definition: The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] ||| Output: [/INST] Significant @@ALPS##-related morbidity occurred in 44% of relatives with intracellular mutations, versus 0% of relatives with extracellular mutations.

Significant @@ALPS##-related morbidity occurred in 44% of relatives with intracellular mutations, versus 0% of relatives with extracellular mutations.

The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Thus, the location of mutations within APT1 strongly influences the development and the severity of ALPS. Useful knowledge : ||| location definition: A position, site, or point in space where something can be found. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| APT1 definition: Antigen peptide transporter 1 (808 aa, ~87 kDa) is encoded by the human TAP1 gene. This protein plays a role in cytoplasmic antigen transport and subsequent presentation by MHC class I molecules. ||| influences definition: The power to have an effect on people, things, or events. ||| development definition: None ||| severity definition: Used of the degree of something undesirable e.g. pain or weather; also, strictness. ||| ALPS definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| Output:

Thus, the location of mutations within APT1 strongly influences the development and the severity of @@ALPS##.

<s> [INST] The task is to label all mentions of diseases in a sentence, by putting them in a specific format. Use the provided knowledge to guide your answer, it provides definitions of terms in the input separated by '|||'.: Identify all the mentions of diseases in the following sentence, by putting @@ in front and a ## behind each of them Input: Thus, the location of mutations within APT1 strongly influences the development and the severity of ALPS. Useful knowledge : ||| location definition: A position, site, or point in space where something can be found. ||| mutations definition: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. ||| APT1 definition: Antigen peptide transporter 1 (808 aa, ~87 kDa) is encoded by the human TAP1 gene. This protein plays a role in cytoplasmic antigen transport and subsequent presentation by MHC class I molecules. ||| influences definition: The power to have an effect on people, things, or events. ||| development definition: None ||| severity definition: Used of the degree of something undesirable e.g. pain or weather; also, strictness. ||| ALPS definition: Rare congenital lymphoid disorder due to mutations in certain Fas-Fas ligand pathway genes. Known causes include mutations in FAS, TNFSF6, NRAS, CASP8, and CASP10 proteins. Clinical features include LYMPHADENOPATHY; SPLENOMEGALY; and AUTOIMMUNITY. ||| Output: [/INST] Thus, the location of mutations within APT1 strongly influences the development and the severity of @@ALPS##.

Thus, the location of mutations within APT1 strongly influences the development and the severity of @@ALPS##.