Document Classification

Section Type: RESULTS

Text: At the lowest dose, anti-FXa activity A (max) was 0. 16 (0. 02) IU/mL and AUC (0-24) was 1. 11 (0. 24) IU * h/mL, At the highest dose anti-FXa activity A (max) was 1. 67 (0. 15) IU/mL ; AUC (0-24) was 21. 48 (4. 46) IU * h/mL and t was 8. 05 h. Mean T (max) (all doses) was 2. 86 (0. 39) h. RO-14 showed proportional and linear pharmacodynamics [normalized A (max) among doses (p = 0. 594) and normalized AUC (0-24) (p = 0. 092), correlations between A (max -) dose (R (2) = 0. 89, p < 0. 001) and AUC (0-24) - dose (R (2) = 0. 86, p < 0. 001)].