Document Classification

Section Type: METHODS

Text: Four separate studies investigated : the in vitro dissolution rates of ibuprofen sodium dihydrate (at pH 1. 2, 3. 5 and 7. 2) ; the bioavailability of ibuprofen sodium dihydrate (in two pharmacokinetic studies ; combined n = 38) compared with conventional ibuprofen, ibuprofen lysinate, ibuprofen arginate and ibuprofen liquagels (all 2 x 200 mg ibuprofen) ; and the gastroduodenal tolerance of ibuprofen sodium dihydrate and ibuprofen arginate (both 2 x 200 mg ibuprofen t. i. d.) in an endoscopy safety study, where endoscopy was performed at baseline and at the end of each treatment period using a five-point scale to assess the integrity of the gastric and duodenal mucosa.