Document Classification

Section Type: METHODS

Text: The patients were randomized into 4 treatment groups : V1 -- velcade 1. 3 mg/m2 intravenously on days 1, 4, 8, and 11 of a 21-day cycle ; V2 -- velcade 1. 3 mg/m2 intravenously on days 1, 4, 8, and 11, melphalan 20 mg orally on day 2 of a 28-day cycle ; V3 -- velcade 1. 3 mg/m2 intravenously on days 1, 4, 8, and 11, melphalan 9 mg/m2 orally for 4 days, prednisolone 60 mg/m2 orally for 4 days of a 42-day cycle ; V4 -- velcade 1. 3 mg/m2 intravenously on days 1, 4, 8, and 11, melphalan 9 mg/m2 orally for 4 days, prednisolone 60 mg/m2 orally for 4 days, cyclophosphanum, 250 mg/m2 intravenously dropwise on days 1 to 7 of a 60-day cycle.