Document Classification

Section Type: RESULTS

Text: OPC-31260 co-administered with furosemide induced an increase in PNa and serum osmolality (F : 281. 6 + / - 0. 7, O+F : 284. 9 + / - 0. 7 mOsm/kgH2O) as a result of an additive increase in maximal urine volume (F : 7. 7 + / - 1. 9, O : 6. 8 4 0. 5, O+F : 13. 2 + / - 1. 4 ml/min) with increased electrolyte-free water excretion (F : 0. 35 + / - 0. 15, O : 5. 3 4 0. 5, O+F : 4. 8 + / - 0. 5 ml/min) while maintaining sodium excretion (F : 731 + / - 110, O+F : 1, 064 + / - 149 microEq/min).