Document Classification

Section Type: RESULTS

Text: NT-proBNP-guided therapy led to a higher up-titration of HF medication and was well tolerated, with a dropout rate (12 % vs. 11 %, P = 1. 0) and AE profile [number of AEs/patient-year 4. 7 (2. 8-9. 4) vs. 5. 4 (2. 7-11. 4), P = 0. 69 ; number of severe AEs/patient-year 0. 7 (0-2. 7) vs. 1. 3 (0-3. 9), P = 0. 21] similar to that of symptom-guided therapy, although most subjects in both treatment groups (96 % vs. 95 %, P = 0. 55) experienced at least one AE.