Document Classification

Section Type: RESULTS

Text: Both doses of tiotropium resulted in significant improvement compared with placebo in the co-primary efficacy end points at the end of week 12 (change from baseline in percent-predicted FEV1 AUC0-4h : 2. 5 g : 2. 94 %, 95 % confidence interval 1. 19-4. 70, p = 0. 001 ; 5 g : 3. 39 %, 95 % confidence interval 1. 67-5. 12, p = 0. 0001 ; in percent-predicted trough FEV1 2. 5 g : 2. 24 %, p = 0. 2 ; 5 g : 2. 22 %, p = 0. 02).