Document Classification

Section Type: RESULTS

Text: When combined with the * 3 genotype of the CYP3A5 (cytochrome P450, family 3, subfamily A, polypeptide 5) gene, the rs35599367C > T SNP was also associated with a risk of supratherapeutic Tac concentrations (> 15 g/L) during the first 3 days after surgery, with an odds ratio of 8. 7 for carriers of the CYP3A4 T allele plus CYP3A5 * 3 / * 3 (P = 0. 027) and 4. 2 for the CYP3A4 CC homozygotes plus CYP3A5 * 3 / * 3 (P = 0. 002), compared with CYP3A4 CC homozygotes having 1 or 2 CYP3A5 * 1 alleles.