Document Classification

Section Type: RESULTS

Text: After oral administration, pretreatment with grapefruit juice led to a 56 % increase in peak plasma concentration (Cmax), a 79 % increase in time to reach Cmax (tmax), and a 52 % increase in the area under the plasma concentration-time curve (AUC) of midazolam, which was associated with an increase in the bioavailability from 24 % + / - 3 % (water) to 35 % + / - 3 % (Grapefruit juice ; mean + / - SEM, p < 0. 01) After oral administration of midazolam, pretreatment with grapefruit juice was associated with a 105 % increase in tmax and with a 30 % increase in the AUC of alpha-hydroxymidazolam.