Document Classification

Section Type: METHODS

Text: Following clinical work-up and NSAID discontinuation for at least 3 days (run-in period of only 3-7 days), osteoarthritis subjects were randomized to 1-month periods of ibuprofen (400-600 mg t. i. d.) or piroxicam (10-20 mg o. d.) with one month of paracetamol (1000 mg t. i. d.) in the middle as a '' wash-out '' interval, continuing the prescribed amlodipine (5-10 mg o. d.) or lisinopril/hydrochlorothiazide fixed drug combination (10/6. 25 -20 / 12. 5 mg o. d.), while control subjects (hypertensives with no osteoarthritis) were just keeping their antihypertensive therapy.