Document Classification

Section Type: RESULTS

Text: Administration of quinine plus nevirapine resulted in significant decreases (P < 0. 01) in the total area under the concentration-time curve (AUC (T)), maximum plasma concentration (C (max)) and terminal elimination half-life (T ((1/2) beta)) of quinine compared with values with quinine dosing alone (AUC : 53. 29 + / - 4. 01 vs 35. 48 + / - 2. 01 h mg/l ; C (max) : 2. 83 + / - 0. 16 vs 1. 81 + / - 0. 06 mg/l ; T ((1/2) beta) : 11. 35 + / - 0. 72 vs 8. 54 + / - 0. 76 h), while the oral plasma clearance markedly increased (11. 32 + / - 0. 84 vs 16. 97 + / - 0. 98 l/h).