Document Classification

Section Type: RESULTS

Text: As compared with placebo, tranexamic acid reduced allogeneic erythrocyte requirement-both the volume transfused (4. 84 5. 85 versus 9. 36 11. 41 units ; mean difference -4. 52 units ; 95 % interval confidence [CI], -7. 85 to -1. 19 units ; p < 0. 001) and the ratio exposed (72. 4 % versus 91. 5 % ; risk difference in percentage point, -19. 1 ; 95 % CI, -32. 6 to -5. 59 ; relative risk, 0. 79 ; 95 % CI, 0. 66 to 0. 94 ; p = 0. 007) - blood loss (1069. 1 565. 5 mL versus 1449. 8 899. 8 mL ; mean difference, -380. 7 mL ; 95 % CI, -656. 4 to -104. 9 mL ; p = 0. 005), major bleeding (50. 0 % versus 78. 0 % ; risk difference, -28. 0 ; 95 % CI, -44. 6 to -11. 3 ; relative risk, 0. 64 ; 95 % CI, 0. 48 to 0. 86 ; p = 0. 002), and reoperation (0. 0 % versus 10. 2 % ; risk difference, -10. 2 ; 95 % CI, -17. 9 to -2. 46 ; relative risk, 0. 08 ; 95 % CI, 0. 00 to 1. 36 ; p = 0. 01).