Document Classification

Section Type: RESULTS

Text: RB006 increased the activated partial thromboplastin time dose dependently ; the median activated partial thromboplastin time at 10 minutes after a single intravenous bolus of 15, 30, 50, and 75 mg RB006 was 29. 2 seconds (25th and 75th percentiles, 28. 1 and 29. 8 seconds), 34. 6 seconds (25th and 75th percentiles, 30. 9 and 40. 0 seconds), 46. 9 seconds (25th and 75th percentiles, 40. 3 and 51. 1 seconds), and 52. 2 seconds (25th and 75th percentiles, 46. 3 and 58. 6) (P < 0. 0001 ; normal 25th and 75th percentiles, 27 and 40 seconds).