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Section Type: RESULTS

Text: At day 29, mean changes from baseline (vs. placebo) in fasting plasma glucose (FPG) were : cohort A, -1. 92 mmol/L ; B, -1. 98 mmol/L ; C, -1. 74 mmol/L ; D, -0. 73 mmol/L ; changes in weighted mean glucose AUC (0-4) were : cohort A, -2. 86 mmol/L ; B, -3. 58 mmol/L ; C, -2. 51 mmol/L ; D, -1. 44 mmol/L (for FPG and AUC (0-4), all p < or = 0. 002 except 100 mg sc monthly, p = NS) ; changes from baseline HbA (1c) were : cohort A, -0. 58 % ; B, -0. 57 % ; C, -0. 63 % ; and D, -0. 51 % (all p < 0. 03).