Document Classification

Section Type: RESULTS

Text: GC-MS measurements revealed Cmax values of asimadoline in plasma ranging from 18 ng ml (-1) at the 1 mg dose, 91 ng ml (-1) at the 5 mg dose, to 214 ng ml (-1) at the 10 mg dose after an average of 1. 1-1. 4 h. Without effects on blood pressure, heart rate, GFR or urine electrolyte excretion, urine volume increased after 1-2 h after administration of 5 and 10 mg asimadoline from 3. 3 + / -1. 3 to 5. 6 + / -1. 4 (P < 0. 05) and from 3. 2 + / -1. 6 to 5. 5 + / -2. 2 ml min (-1) (P < 0. 01), respectively.