Document Classification

Section Type: RESULTS

Text: When the docetaxel dose was escalated to 70 mg/m (2), the carboplatin MTD was reached in schedule A, and the dose-limiting toxicity was not observed in schedule B. Tumor response was observed in 4 of 22 patients (18 %) with schedule A and 8 of 19 (42 %) with schedule B. Clearances of both drugs were not affected by sequence : 111. 2 + / -26. 8 ml/min and 107. 8 + / -29. 0 ml/min for carboplatin (P = 0. 69), and 26. 7 + / -8. 3 l/h and 22. 8 + / -7. 0 l/h for docetaxel (P = 0. 19) in schedules A and B, respectively.