Document Classification

Section Type: RESULTS

Text: We evaluated the relation between univariate and multivariate predictors of intracranial haemorrhage and the effect of treatment with either reteplase alone (10 U bolus twice, 30 min apart) with standard-dose heparin (5000 U bolus followed by an infusion of 1000 Uh (-1) for patients > or = 80 kg and 800 Uh (-1) for those < 80 kg) or combination therapy with abciximab (0. 25 mg/kg bolus and 0. 125 microg/kg/min for 12h) and half-dose reteplase (two boluses of 5U 30 min apart) with reduced-dose heparin (60 Ukg (-1) bolus, maximum 5000 U, followed by an infusion of 7 Ukg (-1) h (-1)) in the 16 588 patients randomized in the GUSTO V trial.