Document Classification

Section Type: RESULTS

Text: Ten independent prognostic factors other than treatment group were identified in multivariate analysis : (a) presence of liver metastases [hazard ratio (HR), 1. 66 ; P = 0. 019], (b) number of metastatic sites (HR, 1. 63 if > or = 2 sites ; P = 0. 001), (c) clinically significant pain (HR, 1. 48 ; P < 0. 0001), (d) Karnofsky performance status (HR, 1. 39 if < or = 70 ; P = 0. 016), (e) type of progression (HR, 1. 37 for measurable disease progression and 1. 29 for bone scan progression ; P = 0. 005 and 0. 01, respectively), (f) pretreatment prostate-specific antigen (PSA) doubling time (HR, 1. 19 if < 55 days ; P = 0. 066), (g) PSA (HR, 1. 17 per log rise ; P < 0. 0001), (h) tumor grade (HR, 1. 18 for high grade ; P = 0. 069), (i) alkaline phosphatase (HR, 1. 27 per log rise ; P < 0. 0001), and (j) hemoglobin (HR, 1. 11 per unit decline ; P = 0. 004).