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Section Type: RESULTS

Text: In the final multivariate model adjusting for all tested covariates, older age (hazard ratio [HR] = 1. 41 / decade older, 95 % confidence interval [CI] = 1. 05 to 1. 90, P =. 022), use of systemic antihypertensives (HR = 2. 53, 95 % CI = 1. 32 to 4. 87, P =. 005), and mean ocular perfusion pressure (HR = 1. 21 / mm Hg lower, 95 % CI = 1. 12 to 1. 31, P <. 001) were associated with progression whereas randomization to brimonidine revealed a protective effect (HR = 0. 26, 95 % CI = 0. 12 to 0. 55, P <. 001).