Document Classification

Section Type: RESULTS

Text: Following intravenous administration of metronidazole to the placebo group and omeprazole treated group respectively, the gastric transfer of metronidazole was significantly reduced from 15. 5 + / - 10. 4 % to 2. 6 + / - 1. 0 % of the dose (P = 0. 007 ; 95 % CI of difference 4. 8 to 21. 0) with concomitant changes in the metronidazole AUC (from 77. 5 + / - 18. 0 mumol l-1 h to 352. 6 + / - 182. 1 mumol l-1 h ; P = 0. 0003 ; 95 % CI of difference 127. 6 to 422. 7), Cmax (from 61. 4 + / - 26. 5 mumol l-1 to 271. 8 + / - 104. 3 mumol l-1 ; p = 0. 0001 ; 95 % CI of difference 118. 6 to 302. 1).