Document Classification

Section Type: RESULTS

Text: At week 12, the change from baseline for 10 micrograms E2 compared with placebo demonstrated significant improvement in vaginal Maturation Index (proportion of parabasal cells : -37 % compared with -9 % ; superficial cells : 13 % compared with 4 % ; intermediate cells : 24 % compared with 5 % ; P <. 001 for each), Maturation Value (25. 0 compared with 6. 5, P <. 001), grading of vaginal health (-0. 91 compared with -0. 51, P <. 001), vaginal pH grade (-1. 3 compared with -0. 4, P <. 001), and most bothersome symptoms score (-1. 23 compared with -0. 87, P =. 003).