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Section Type: METHODS

Text: After estimations of the MEC of levobupivacaine and diamorphine, a further 60 patients were randomized in the second phase to one of the three mixtures : (a) diamorphine 70 microg ml (-1) (fixed) and levobupivacaine (testing interval 0. 004 % w/v, starting at 0. 044 % w/v) ; (b) levobupivacaine 0. 044 % w/v (fixed) and diamorphine (testing interval 7 microg ml (-1), starting at 70 microg ml (-1)) ; and (c) bivariate diamorphine and levobupivacaine (testing intervals of 7 microg ml (-1) and 0. 004 % w/v starting at 70 microg ml (-1) and 0. 044 % w/v respectively).