Document Classification

Section Type: METHODS

Text: A total of 207 eligible patients with a performance status of 0 or 1 were randomized postoperatively between days 21 and 70 to one of the two treatment groups : group A, LV 20 mg/m2 i. v. bolus and 5-FU 425 mg/m2 i. v. days 1-5 and 29-33, LV 20 mg/m2 and 5-FU 400 mg/m2 days 57-60 and 85-88, LV 20 mg/m2 and 5-FU 380 mg/m2 days 1-5 and 29-33 with the second day 1 occurring 28 days after the completion of RT (45 Gy) ; group B, LV, 5-FU and RT as in group A, and IFN-alpha 5 x 10 (6) IU s. c. three times during each week chemotherapy is given.