Document Classification

Section Type: RESULTS

Text: Population parameter estimates were 3. 02 hour-1 and 0. 49 hour-1 for rates of input and output of the active moiety (ies), respectively, IA50 (the unscaled amount of R-568 associated with 50 % of Emax) was 16. 3 mg, Emax (the maximum effect caused by R-568 expressed as a fraction of the rate of PTH secretion in the absence of any drug effect) was 89 %, CPTH (baseline) (the baseline PTH plasma concentration in the absence of any drug effect) was 34. 6 pg/mL, KePTH (the elimination rate constant for PTH) was 1. 73 hour-1, amplitude of the circadian variability in PTH secretion was 5. 8 %, and the time of peak PTH secretion occurred at about 6 PM.