Document Classification

Section Type: RESULTS

Text: Good concordance between microdose and therapeutic dose pharmacokinetics was observed for diazepam (half-life [t ((1/2))] of 45. 1 hours, clearance [CL] of 1. 38 L/h, and volume of distribution [V] of 90. 1 L for 100 microg and t ((1/2)) of 35. 7 hours, CL of 1. 3 L/h, and V of 123 L for 10 mg), midazolam (t ((1/2)) of 4. 87 hours, CL of 21. 2 L/h, V of 145 L, and oral bioavailability [F] of 0. 23 for 100 microg and t ((1/2)) of 3. 31 hours, CL of 20. 4 L/h, V of 75 L, and F of 0. 22 for 7. 5 mg), and development compound ZK253 (F = < 1 % for both 100 microg and 50 mg).