Document Classification

Section Type: RESULTS

Text: Administration of anastrozole resulted in no clinically significant changes in the pharmacokinetics of either R - or S-warfarin compared with placebo for AUC (ng ml-1 h) (glsmean, R-warfarin ; anastrozole 93619. 9, placebo 91127. 91, 95 % CI 0. 988-1. 068 ; S-warfarin ; anastrozole 57129. 21, placebo 55676. 34, 95 % CI 0. 979-1. 076), CL/F (ml min-1) (glsmean, R-warfarin ; anastrozole 2. 23, placebo 2. 29, 95 % CI 0. 937-1. 012 ; S-warfarin ; anastrozole 3. 65, placebo 3. 74, 95 % CI 0. 929-1. 021) and t1/2 (h) (lsmean, R-warfarin ; anastrozole 55. 40, placebo 55. 15, 95 % CI-2. 083 -2. 592 ; S-warfarin ; anastrozole 39. 38, placebo 40. 98, 95 % CI-6. 189 -2. 996).