Document Classification

Section Type: RESULTS

Text: The main findings were : 1) dogs that received rLdccys1 with P. acnes did not display increase of the following clinical signs : weight loss, alopecia, onychogryphosis, cachexia, anorexia, apathy, skin lesions, hyperkeratosis, ocular secretion, and enlarged lymph nodes ; they also exhibited a significant reduction in the spleen parasite load in comparison to the control dogs ; 2) rLdccys1-treated dogs exhibited a significant delayed type cutaneous hypersensitivity elicited by the recombinant antigen, as well as high IgG2 serum titers and low IgG1 serum titers ; sera from rLdccys1-treated dogs also contained high IFN - and low IL-10 concentrations ; 3) control dogs exhibited all of the clinical signs of visceral leishmaniasis and had low serum IgG2 and IFN - levels and high concentrations of IgG1 and IL-10 ; 4) all of the dogs treated with rLdccys1 were alive 12 months after treatment, whereas dogs which received either saline or P. acnes alone died within 3 to 7 months.