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Section Type: RESULTS

Text: The following GCV concentrations (mean + / - SD) were determined : with CrCl of > or = 70 ml/min, the minimum steady-state concentration (Cmin) and maximum concentration (Cmax) were 0. 78 + / -0. 46 microg/ml and 1. 42 + / -0. 37 microg/ml, respectively, with a 24-hr area under the concentration time curve (AUC0-24) of 24. 7 + / -7. 8 microg x hr/ml ; with CrCl of 50-69 ml/min, the Cmin and Cmax were 1. 93 + / -0. 48 and 2. 57 + / -0. 39 microg/ml, respectively, with an AUC0-24 of 52. 1 + / -10. 1 microg x hr/ml ; with CrCl of 25-50 ml/min, the Cmin and Cmax were 0. 41 + / -0. 27 and 1. 17 + / -0. 32 microg/ml, respectively, with an AUC0-24 of 14. 6 + / -7. 4 microg x hr/ml.