Document Classification

Section Type: RESULTS

Text: The best prediction formula for the AUC of racemic lansoprazole, using the fewest sampling points of (R) - and (S) - lansoprazole, was AUC = 6. 5 x C (3h) of (R) - lansoprazole + 13. 7 x C (3h) of (S) - lansoprazole - 9, 917. 3 x G1 - 14, 387. 2 x G2 + 7, 103. 6 (P < 0. 001), where C (3h) is the plasma concentration 3 h after administration, G1 = 1 for the homozygous extensive metabolizer (EM) and 0 for the other genotypes, G2 = 1 for the heterozygous EM and 0 for the other genotypes.