Document Classification

Section Type: RESULTS

Text: In the dose-finding study, the AZD3582 750 -, 1500 -, and 2250-mg groups were superior to placebo in the primary variables '' time to rescue medication (0-8 hours) '' (hazard ratios [HRs] [95 % CIs], 0. 17 [0. 07-0. 42], P < 0. 003 ; 0. 23 [0. 11-0. 50], P < 0. 001 ; and 0. 15 [0. 06-0. 36], P < 0. 001, respectively), '' time to meaningful pain relief '' (HRs [95 % CIs], 3. 42 [1. 87-6. 25], P < 0. 003 ; 2. 49 [1. 37-4. 50], P < 0. 003 ; and 3. 07 [1. 70-5. 55], P < 0. 001, respectively), and MPID (analysis of covariance [ANCOVA] least squares mean [LSM] differences [95 % CIs], 25. 8 [17. 3-34. 4], P < 0. 003 ; 20. 4 [12. 1-28. 7], P < 0. 003 ; and 29. 3 [20. 9-37. 6], P < 0. 001, respectively).