Document Classification

Section Type: RESULTS

Text: At the 20 year follow up (median follow up for live patients : 249 months) chemotherapy and radiation therapy, compared with chemotherapy alone, were associated with a statistically significant improvement in all end points analyzed, including survival free of isolated locoregional recurrences (74 % versus 90 %, respectively ; relative risk [RR] = 0. 36, 95 % confidence interval [CI] = 0. 18 to 0. 71 ; P =. 002), systemic relapse-free survival (31 % versus 48 % ; RR = 0. 66, 95 % CI = 0. 49 to 0. 88 ; P =. 004), breast cancer-free survival (48 % versus 30 % ; RR = 0. 63, 95 % CI = 0. 47 to 0. 83 ; P =. 001), event-free survival (35 % versus 25 % ; RR = 0. 70, 95 % CI = 0. 54 to 0. 92 ; P =. 009), breast cancer-specific survival (53 % versus 38 % ; RR = 0. 67, 95 % CI = 0. 49 to 0. 90 ; P =. 008), and, in contrast to the 15-year follow-up results, overall survival (47 % versus 37 % ; RR = 0. 73, 95 % CI = 0. 55 to 0. 98 ; P =. 03).