Document Classification

Section Type: RESULTS

Text: Itraconazole affected the pharmacokinetic parameters of S-fexofenadine more, and increased AUC (0, 24 h) of S-fexofenadine and R-fexofenadine by 4. 0-fold (95 % CI of differences 2. 8, 5. 3 ; P < 0. 001) and by 3. 1-fold (95 % CI of differences 2. 2, 4. 0 ; P = 0. 014), respectively, and Ae (0, 24 h) of S-fexofenadine and R-fexofenadine by 3. 6-fold (95 % CI of differences 2. 6, 4. 5 ; P < 0. 001) and by 2. 9-fold (95 % CI of differences 2. 1, 3. 8 ; P < 0. 001), respectively.