Document Classification

Section Type: METHODS

Text: Rabbits were anesthetized (ketamine/xylazine 35 + 5 mg kg (-1), IM), the trachea was intubated and randomized to four groups - (1) CMV-1 (n = 14), ventilated with traditional conventional volume-cycled MV [V (T) = 12 mL kg (-1), RR = 20, positive end-expiratory pressure (PEEP) = 0 cmH (2) O] ; (2) CMV-2 (n = 13), ventilated with a modern lung-protective regimen of volume-cycled MV (V (T) = 6 mL kg (-1), RR = 40, PEEP = 5 cmH (2) O) ; (3) HFPV (n = 17) ventilated with high-frequency percussive ventilation [high-frequency oscillations (450 minute (-1)) superimposed on 40 minute (-1) low-frequency respiratory cycles, I : E ratio = 1:1], oscillatory continuous positive airway pressure (CPAP) of 7-10 cmH (2) O, and demand CPAP of 8-10 cmH (2) O. (4) A fourth group, spontaneously ventilating (SV, n = 17), was anesthetized, intubated, but not ventilated mechanically.