Document Classification

Section Type: RESULTS

Text: Among healthy volunteers using aqueous timolol, poor metabolisers (PMs, n = 2) of CYP2D6 had higher maximum plasma concentrations (C (max), values 2. 63 and 2. 94 ng/ml), longer elimination half-lives (T (1/2), 5. 49 and 6. 75 h), and higher area-under-curve (AUC, 19. 54 and 23. 25 ng. h / ml) than intermediate [IMs, n = 6, mean + / - SD 1. 73 + / -0. 59 ng/ml (not significant), 3. 30 + / -0. 48 h, 11. 32 + / -3. 72 ng. h / ml], extensive (EMs, n = 8, 1. 60 + / -0. 72 ng/ml, 3. 24 + / -1. 24 h, 8. 52 + / -6. 12 ng. h / ml) and ultra-rapid (UMs, n = 2, values 1. 23 and 1. 67 ng/ml, 2. 22 and 2. 52 h, 6. 16 and 6. 94 ng. h / ml) metabolisers.