Document Classification

Section Type: RESULTS

Text: Compared with placebo, patients treated with PMF-100 reported hard/pellety stools and straining at defecation less frequently, a significantly higher bowel frequency (week 12 : 7. 4 (3. 1) v 4. 3 (2. 5) bm/week, 95 % CI 1. 64, 4. 42 ; week 24 : 7. 4 (3. 2) v 5. 4 (2. 1) bm/week, 95 % CI 0. 13, 3. 93), reduced consumption of laxative/four weeks (week 12 : 0. 7 (2. 7) v 2. 2 (3. 3), 95 % CI -2. 29, 0. 03 ; week 24 : 0. 2 (0. 8) v 1. 4 (2), 95 % CI -2. 07, -0. 023), reduced mean number of sachets used (week 12 : 33 (13) v 43 (12), 95 % CI -17. 24, 4. 56 ; week 24 : 33 (13) v 44 (12), 95 % CI -19. 68, -2. 24), and reduced number of drop outs for therapy failure (16 v 3 ; p < 0. 005).