Document Classification

Section Type: METHODS

Text: Eligible chemotherapy - and radiotherapy-naive patients with stage IIB to IVA disease and Karnofsky performance score 70 were randomly assigned to arm A (cisplatin 40 mg/m (2) and gemcitabine 125 mg/m (2) weekly for 6 weeks with concurrent external-beam radiotherapy [XRT] 50. 4 Gy in 28 fractions, followed by brachytherapy [BCT] 30 to 35 Gy in 96 hours, and then two adjuvant 21-day cycles of cisplatin, 50 mg/m (2) on day 1, plus gemcitabine, 1, 000 mg/m (2) on days 1 and 8) or to arm B (cisplatin and concurrent XRT followed by BCT only ; dosing same as for arm A).