Document Classification

Section Type: RESULTS

Text: Venoconstriction to ET-1 and NA was not affected by ET A blockade in either group ; however, carriers of the 825T allele demonstrated a markedly enhanced venoconstriction to ET-1 and NA (median effective concentration [ED50] for ET-1 after darusentan [placebo] : 2. 5 + / - 0. 2 pmol/min for CT/TT [2. 7 + / - 0. 3 pmol/min], P =. 42 ; 3. 9 + / - 0. 6 pmol/min for CC [4. 6 + / - 0. 3 pmol/min], P =. 42 ; P =. 046 [P =. 0005] for CT/TT versus CC) (ED50 for NA after darusentan [placebo] : 5. 2 + / - 1. 2 ng/min for CT/TT [7. 3 + / - 1. 2 ng/min], P =. 20 ; 32. 9 + / - 7. 1 ng/min for CC [19. 7 + / - 5. 5 ng/min], P =. 75 ; P =. 0008 [P =. 026] for CT/TT versus CC).