Document Classification

Section Type: BACKGROUND

Text: To compare irinotecan with the Nordic 5-fluorouracil (5-FU) and folinic acid (FA) bolus schedule [irinotecan 180 mg/m (2) on day 1, 5-FU 500 mg/m (2) and FA 60 mg/m (2) on day 1 and 2 (FLIRI)] or the Lv5FU2 schedule [irinotecan 180 mg/m (2) on day 1, FA 200 mg/m (2), 5-FU bolus 400 mg/m (2) and infused 5-FU 600 mg/m (2) on day 1 and 2 (Lv5FU2-IRI)] due to uncertainties about how to administrate 5-FU with irinotecan.