Document Classification

Section Type: RESULTS

Text: After adjusting for treatment with losartan vs. atenolol, baseline risk factors for death, baseline HR, baseline and in-treatment systolic and diastolic pressure, incident myocardial infarction, and the known predictive value of baseline and in-treatment QRS duration and ECG LVH, higher in-treatment HR in time-varying multivariable Cox models remained strongly predictive of mortality : every 10 bpm higher HR was associated with a 16 % increased adjusted risk of CV mortality (95 % CI : 6-27 %) and a 25 % greater risk of all-cause mortality (95 % CI : 17-33 %), with persistence or development of a HR 84 associated with a 55 % greater risk of CV death (95 % CI : 16-105 %) and a 79 % greater adjusted risk of all-cause mortality (95 % CI : 46-121 %).