Document Classification

Section Type: RESULTS

Text: Twenty-four hour GMP excretion (1. 4 + / - 1. 1 versus 0. 8 + / - 0. 5 micromol/day, P < 0. 01) and Ccr (150 + / - 43 versus 125 + / - 42 ml/min, P < 0. 05) were higher and plasma endothelin level (2. 5 + / - 0. 6 versus 3. 1 + / - 0. 8 pg/ml, P < 0. 05) was lower with L-arginine treatment compared to placebo treatment In addition, the relative increase of UNa and GFR after saline loading were significantly higher in L-arginine treatment (UNa, 47 + / - 12 % ; GFR, 44 + / - 31 %) than in placebo treatment (UNa, 34 + / - 9 % ; GFR, 22 + / - 29 %) (P < 0. 05).