Document Classification

Section Type: METHODS

Text: Adult patients with newly diagnosed GBM were registered and randomized following surgery to one of 4 treatment arms : Arm A, accelerated hyperfractionation alone using 2 fractions a day of 1. 6 Gy to a total dose of 70. 4 Gy in 44 fractions ; Arm B, accelerated hyperfractionation as above plus DFMO 1. 8 gm/m2 by mouth every 8 h beginning one week before radiation until the last fraction was given ; Arm C, single-fraction irradiation of 1. 8 Gy/day to 59. 4 Gy ; Arm D, single-fraction irradiation as in Arm C plus DFMO given as in Arm B. Patients were followed for progression-free survival (PFS) and overall survival (OS), as well as for toxicity.