Document Classification

Section Type: METHODS

Text: 224 patients with locally advanced breast cancer were randomly assigned to 75 mg/m (2) cyclophosphamide given orally on days 1-14, and 60 mg/m (2) epirubicin and 500 mg/m (2) fluorouracil both given intravenously on days 1 and 8, for six cycles every 28 days (6 months'treatment ; standard treatment) and 224 patients to 830 mg/m (2) cyclophosphamide and 120 mg/m (2) epirubicin both given intravenously on day 1, and 5 microg/kg filgrastim per day given subcutaneously on days 2-13, for six cycles every 14 days (3 months'treatment ; dose-intensive treatment).