Document Classification

Section Type: RESULTS

Text: Co-administration of multiple oral doses of 20 mg paroxetine once daily with a single oral dose of the 0. 4 mg tamsulosin HCl capsule increased the adjusted geometric mean (gMean) values of C (max) and AUC (0,) of tamsulosin by factors of 1. 34 (90 % CI 1. 21, 1. 49) and 1. 64 (90 % CI 1. 44, 1. 85), respectively, and increased the terminal half-life (t (1/2)) of tamsulosin HCl from 11. 4 h to 15. 3 h. Co-administration of multiple oral doses of 400 mg ketoconazole once daily with a single oral dose of the 0. 4 mg tamsulosin increased the gMean values of C (max) and AUC (0,) of tamsulosin by a factor of 2. 20 (90 % CI 1. 96, 2. 45) and 2. 80 (90 % CI 2. 56, 3. 07), respectively.