Document Classification

Section Type: RESULTS

Text: Multivariate analysis showed a 13 % (P < 0. 001) increase in the clinical benefit of CRT-D per 1-point increment in the response score (range, 0-14) and a significant direct correlation between risk reduction associated with CRT-D and response score quartiles : Patients in the first quartile did not derive a significant reduction in the risk of heart failure or death with CRT-D (hazard ratio = 0. 87 ; P = 0. 52) ; patients in the second and third quartiles derived 33 % (P = 0. 04) and 36 % (P = 0. 03) risk reductions, respectively ; and patients in the upper quartile experienced a 69 % (P < 0. 001) risk reduction (P for trend = 0. 005).