Document Classification

Section Type: RESULTS

Text: After 3 weeks of treatment, patients receiving ursodeoxycholic acid (mean daily dose 16 mg/kg body weight) had a significant improvement in pruritus (p < 0. 02), in serum bilirubin (0. 36 + / -0. 19 mg/dl (mean + / - SD) versus 0. 95 + / -0. 48 in patients receiving placebo, p < 0. 01), in aspartate aminotransferase (52 + / -42 IU/l vs 98 + / -44, p < 0. 05) and in alanine aminotransferase (54 + / -50 IU/l vs 229 + / -154, p < 0. 01) ; serum total bile salts also tended to be lower in patients receiving ursodeoxycholic acid (26. 3 + / -33. 7 micromol/l vs 55. 0 + / -44. 8, p N. S.).