Document Classification

Section Type: RESULTS

Text: In patients untreated with ICS at baseline, Arg16Gly and Arg16Arg genotypes were associated with significantly prolonged time to first exacerbation compared with Gly16Gly (vs Arg16Gly p = 00164 ; Arg16Arg p = 00316 ; proportion of patients with at least one exacerbation was 283 % in Arg16Arg, 316 % in Arg16Gly, and 392 % in Gly16Gly), whereas in patients on ICS at baseline, only the Arg16Arg genotype was associated with significantly prolonged time to first exacerbation compared with Gly16Gly (p = 00198 ; not Arg16Gly p = 064 ; proportion of patients with at least one exacerbation was 359 % in Arg16Arg, 467 % in Arg16Gly, and 448 % in Gly16Gly).