Document Classification

Section Type: RESULTS

Text: CYP2C19 loss-of-function but not PON1 variants were significantly associated with increased risk of major cardiovascular events (death, MI, and urgent coronary revascularization) occurring during long-term clopidogrel exposure in 371 young post-MI patients (age < 45 years) enrolled in the AFIJI cohort (CYP2C19 loss-of-function allele carrier versus noncarrier : hazard ratio, 2. 26 ; 95 % confidence interval, 1. 15-4. 41, P = 0. 02 ; PON1 QQ192 versus QR/RR192 : hazard ratio, 1. 03 ; 95 % confidence interval, 0. 50-2. 11, P = 0. 93 ; PON1 LL55 versus LM/MM55 : hazard ratio, 1. 52 ; 95 % confidence interval, 0. 75-3. 08, P = 0. 24).