Document Classification

Section Type: METHODS

Text: An open, randomized trial was conducted to test for equivalence between the standard melarsoprol regimen and 3 other regimens, as follows : standard melarsoprol therapy (3 series of 3. 6 mg/kg/day intravenously [iv] for 3 days, with 7-day breaks between the series) ; 10-day incremental-dose melarsoprol therapy (0. 6 mg/kg iv on day 1, 1. 2 mg/kg iv on day 2, and 1. 8 mg/kg iv on days 3-10) ; nifurtimox monotherapy for 14 days (5 mg/kg orally 3 times per day) ; and consecutive 10-day melarsoprol-nifurtimox combination therapy (0. 6 mg/kg iv melarsoprol on day 1, 1. 2 mg/kg iv melarsoprol on day 2, and 1. 2 mg/kg/day iv melarsoprol combined with oral 7. 5 mg/kg nifurtimox twice a day on days 3-10).