Document Classification

Section Type: RESULTS

Text: Topiramate was more efficacious than placebo in reducing body mass index (calculated as weight in kilograms divided by height in meters squared) (mean difference, 1. 08 ; 95 % confidence interval [CI], 0. 81-1. 34 ; P <. 001), all liver enzyme levels (P <. 01 for all comparisons), plasma cholesterol level (mean difference, 13. 30 mg/dL ; 95 % CI, 5. 09-21. 44 mg/dL ; P =. 002), and systolic (mean difference, 9. 70 mm Hg ; 95 % CI, 6. 81-12. 60 mm Hg ; P <. 001) and diastolic (mean difference, 6. 74 mm Hg ; 95 % CI, 4. 57-8. 90 mm Hg ; P <. 001) blood pressure to about prehypertension levels-effects that might lower the risk of fatty liver degeneration and cirrhosis as well as cardiovascular disease.