Document Classification

Section Type: RESULTS

Text: In addition, the parameters of glucose assimilation were significantly decreased as compared with placebo in the subgroup of 7 subjects with plasma clonazepam concentrations higher than 6. 0 ng ml-1 (median and lower limit of effective therapeutic concentrations) : 1. 37 + / - 0. 3 versus 2. 84 + / - 0. 60 x 10 (-2) min-1 (P = 0. 028) for the coefficient of glucose tolerance (Kg), 2. 18 + / - 0. 29 versus 3. 71 + / - 0. 89 x 10 (-4) microUml-1min-1 (P = 0. 018) for insulin sensitivity (Si) and 1. 80 + / - 0. 39 versus 3. 59 + / - 0. 71 x 10 (-2) min-1 (P = 0. 028) for glucose effectiveness at basal insulin (Sg).