Document Classification

Section Type: RESULTS

Text: Six factors independently associated with co-enrollment (all P < 0. 001) were illness severity (odds ratio (OR) 1. 35, 95 % confidence interval (CI) 1. 19 to 1. 53 for each 10-point Acute Physiology and Chronic Health Evaluation (APACHE) II score increase), substitute decision-makers providing consent, rather than patients (OR 3. 31, 2. 03 to 5. 41), experience of persons inviting consent (OR 2. 67, 1. 74 to 4. 11 for persons with > 10 years'experience compared to persons with none), center size (all ORs > 10 for ICUs with > 15 beds), affiliation with trials groups (OR 5. 59, 3. 49 to 8. 95), and main trial rather than pilot phase (all ORs > 8 for recruitment year beyond the pilot).