Document Classification

Section Type: METHODS

Text: Within 5 consecutive trials (2 were randomized) 174 patients have been treated with bolus 5-FU 600 mg/m2 plus folinic acid 300 mg/m2 day 2 to 4 with or without dipyridamole 3 x 75 mg p. o. day 1 to 5 ; 74 patients with bolus 5-FU 300 to 350 mg/m2, folinic acid 200 mg/m2 and interferon 5 x 109 U/m2 s. c. day 1 to 5 ; 18 patients with PALA 250 mg/m2, MTX 250 mg/m2 day 1 and bolus FU 600 mg/m2 day 2 q day 14 and 86 patients with FU 2. 6 g/m2 given as 24-h infusion plus interferon 3 x 10 (9) Ul s. c. and 133 patients with FU 2. 6 g/m2 given as 24-h infusion, folinic acid 500 mg/m2 as 2-h infusion with or without interferon 3 x 10 (9) U s. c.