Document Classification

Section Type: RESULTS

Text: Gemfibrozil decreased the mean (+ / - SD) area under the plasma concentration-time curve [AUC ((0-infinity))] of S-warfarin by 11 %, from 19. 9 + / - 5. 2 mg l (-1) h to 17. 6 + / - 4. 7 mg l (-1) h (95 % CI on the difference -3. 7, -0. 78 ; P < 0. 01) and that of R-warfarin by 6 % from 31. 3 + / - 7. 5 mg l (-1) h during the gemfibrozil phase to 29. 5 + / - 6. 9 mg l (-1) h during the placebo phase (95 % CI -3. 3, -0. 33 ; P < 0. 05).