Document Classification

Section Type: METHODS

Text: Patients (N = 1, 120) with no prior chemotherapy for metastatic disease were randomized to one of the following arms : arm A, 5-FU 2, 600 mg/m2 by 24-hour infusion, weekly ; arm B, N-phosphonoacetyl-l-aspartic acid 250 mg/m2 day l, 5-FU 2, 600 mg/m2 by 24-hour infusion day 2, weekly ; arm C, 5-FU 600 mg/m2 with oral leucovorin (LV) 125 mg/m2 hourly for the preceding 4 hours, weekly ; arm D, 5-FU 600 mg/m2 with intravenous (IV) LV 600 mg/m2, weekly ; arm E, 5-FU 750 mg/m2/d IV by continuous infusion for 5 days, then 750 mg/m2 weekly, and recombinant interferon alfa-2a 9 million units subcutaneously three times weekly.