Document Classification

Section Type: CONCLUSIONS

Text: Elderly patients treated with AA plus P showed improved OS (HR : 0. 64 ; 95 % CI, 0. 478-0. 853 ; p = 0. 0022), TTPP (HR : 0. 76 ; 95 % CI, 0. 503-1. 155 ; p = 0. 1995), and rPFS (HR : 0. 66 ; 95 % CI, 0. 506-0. 859 ; p = 0. 0019), and higher PSA response rate with relative risk (HR : 4. 15 ; 95 % CI, 2. 2-8. 0] ; p 0. 0001) compared with patients treated with PL plus P. Grade 3/4 adverse events occurred in 62 % of elderly patients and in 60 % of patients aged < 75 yr treated with AA plus P. Incidences of hypertension and hypokalaemia, although increased in the AA plus P arm, were similar in both age subgroups and readily managed.