Document Classification

Section Type: METHODS

Text: Between July 25, 2006, and Feb 26, 2010, patients were randomly assigned to two groups : a control group receiving standard fluorouracil-based combined modality treatment, consisting of preoperative radiotherapy of 504 Gy plus infusional fluorouracil (1000 mg/m (2) days 1-5 and 29-33), followed by surgery and four cycles of bolus fluorouracil (500 mg/m (2) days 1-5 and 29 ; fluorouracil group) ; and an experimental group receiving preoperative radiotherapy of 504 Gy plus infusional fluorouracil (250 mg/m (2) days 1-14 and 22-35) and oxaliplatin (50 mg/m (2) days 1, 8, 22, and 29), followed by surgery and eight cycles of adjuvant chemotherapy with oxaliplatin (100 mg/m (2) days 1 and 15), leucovorin (400 mg/m (2) days 1 and 15), and infusional fluorouracil (2400 mg/m (2) days 1-2 and 15-16 ; fluorouracil plus oxaliplatin group).