Document Classification

Section Type: RESULTS

Text: Oral coadministration of clarithromycin resulted in a 1. 7-fold increase of the area under the digoxin plasma concentration-time curve [mean AUC (0, 24) + / - SD 23 + / - 5. 2 vs. 14 + / - 2. 9 microg x L (-1) x h ; 95 % confidence interval (CI) on the difference 7. 0, 12 ; P = 0. 002] and in a reduction of the nonglomerular renal clearance of digoxin [mean ClRng (0, 24) + / - SD 34 + / - 39 vs. 57 + / - 41 mL min-1 ; 95 % CI on the difference 7. 2, 45 ; P = 0. 03].