Document Classification

Section Type: RESULTS

Text: The estimated noncompartmental pharmacokinetic parameters (mean + / - SD) for piperacillin and tazobactam, respectively, were as follows : maximum concentration in plasma 218. 7 + / - 48. 9 micrograms/ml and 27. 8 + / - 9. 1 micrograms/ml ; half-life 1. 07 + / - 0. 22 hours and 1. 00 + / - 0. 27 hours ; elimination rate constant 0. 67 + / - 0. 13 hr-1 and 0. 73 + / - 0. 18 hr-1 ; area under the concentration-time curve from zero hour to infinity 288. 5 + / - 71. 25 mg. hr / L and 36. 3 + / - 9. 55 mg. hr / L ; total plasma clearance 14. 75 + / - 3. 93 L/hour and 14. 78 + / - 4. 39 L/hour ; renal clearance 5. 69 + / - 1. 94 L/hour and 7. 85 + / - 3. 37 L/hour ; volume of distribution at steady state 21. 00 + / - 4. 18 L and 22. 47 + / - 8. 27 L ; and mean residence time 1. 72 + / - 0. 29 hours and 1. 79 + / - 0. 35 hours.