Document Classification

Section Type: METHODS

Text: In a 6-week, randomized, open-label, rater-blinded study, patients with schizophrenia or schizoaffective disorder, on a stable drug dose for more than 30 days at entry, who were intolerant of or exhibiting a suboptimal symptom response to more than 30 days of olanzapine treatment, were randomly assigned to the following switch strategies (common risperidone initiation scheme ; varying olanzapine discontinuation) : (i) abrupt strategy, where olanzapine was discontinued at risperidone initiation ; (ii) gradual 1 strategy, where olanzapine was given at 50 % entry dose for 1 week after risperidone initiation and then discontinued ; or (iii) gradual 2 strategy, where olanzapine was given at 100 % entry dose for 1 week, then at 50 % in the second week, and then discontinued.