Document Classification

Section Type: RESULTS

Text: Following tissue injury, rofecoxib increased the expression of genes associated with degradation of the extracellular matrix, including MMP-1 (64. 7 + / - 6. 5, P =. 010), MMP-3 (41. 7 + / - 4. 8, P =. 007), PLAT (encoding tissue plasminogen activator) (10. 9 + / - 4. 6, P =. 032), and IL8 (encoding interleukin 8) (8. 3 + / - 6. 7, P =. 020), and decreased the expression of TIMP3 (encoding tissue inhibitor of metalloproteinase 3) (6. 2 + / - 2. 8, P =. 027).