Document Classification

Section Type: METHODS

Text: One hundred twenty-two previously untreated patients with stage III/IV SCC of the head and neck were randomized to receive definitive radiotherapy (70 Gy in 7 weeks) concurrently with either cisplatin (75 mg/m (2)) plus tirapazamine (290 mg/m (2) / d) on day 2 of weeks 1, 4, and 7, and tirapazamine alone (160 mg/m (2) / d) on days 1, 3, and 5 of weeks 2 and 3 (TPZ/CIS), or cisplatin (50 mg/m (2)) on day 1 and infusional fluorouracil (360 mg/m (2) / d) on days 1 through 5 of weeks 6 and 7 (chemoboost).