Document Classification

Section Type: RESULTS

Text: The pharmacokinetic parameters of BrTet after single i. v. infusion doses of BrTet 10, 20 and 30 mg/m (2) were as follows : T (max) were 1. 5 h in three groups, C (max) were 24. 79, 39. 59 and 64. 31 microg/L, t (1/2alpha) were 0. 37, 0. 29 and 0. 30 h, t (1/2beta) were 62. 88, 56. 45 and 52. 20 h. AUC (0-194h) were 345. 83, 688. 15 and 1096. 28 microg h/L, Cl were 23. 68, 25. 69 and 25. 66 L h/m (2), V (d) were 157. 73, 156. 96 and 140. 73 L/m (2).