Document Classification

Section Type: RESULTS

Text: Further analysis showed no correlation between ilaprazole metabolism and CYP2C19 genotypes, evidenced by that the AUC ((0-infinity)) of ilaprazole from either CYP3A5 * 1 / * 1 or CYP3A5 * 1 / * 3 groups was much higher in CYP2C19 wt/wts (n = 4) than that in CYP2C19 wt/mts (n = 3) (P < 0. 001), but the C (max) and AUC ((0-6)) of ilaprazole from CYP3A5 * 3 / * 3 groups, were significantly lower in CYP2C19 wt/wts (n = 3) compared to CYP2C19 wt/mts (n = 4) (P < 0. 01).