Document Classification

Section Type: METHODS

Text: Multicentric, randomized, double blinded and paralleled control led trial was conducted on patients (aged between 18 and 65) with liver fibrosis in chronic hepatitis B Indexes observed : (1) hepatic histological changes and HBV markers were observed at 0 and 24th week during the treatment ; serological indexes (HA, LN, P-III-P, IV-C) were determined and B ultrasound examination of spleen and liver was taken at 0, 12th, 24th week ; liver function (during the period of follow-up, liver function and serological indexes for liver fibrosis were evaluated) were observed at 0, 6th, 12th, 18th, 24th week ; (2) indexes for safety : blood and urine routine tests, renal function and ECG were examined.