Document Classification

Section Type: RESULTS

Text: Mean highest placebo-matched change from baseline in QTc was -3. 0 [90 % confidence interval (CI) -5. 4, -0. 6] ms. At supratherapeutic axitinib exposures achieved with potent cytochrome P450 3A4/5 inhibition by ketoconazole, the model predicted mean QTc change of 6. 5 (90 % CI 4. 4-8. 5) ms. The slope population mean estimate was -0. 331 (95 % CI -0. 860, 0. 198) msmL/g for ketoconazole alone and 0. 0725 (0. 0445-0. 1005) msmL/ng for axitinib in the presence of ketoconazole.