Document Classification

Section Type: RESULTS

Text: After 48 weeks of treatment, significantly more patients who received 10 mg or 30 mg of adefovir dipivoxil per day than who received placebo had histologic improvement (53 percent [P < 0. 001], 59 percent [P < 0. 001], and 25 percent, respectively), a reduction in serum HBV DNA levels (by a median of 3. 52 [P < 0. 001], 4. 76 [P < 0. 001], and 0. 55 log copies per milliliter, respectively), undetectable levels (fewer than 400 copies per milliliter) of serum HBV DNA (21 percent [P < 0. 001], 39 percent [P < 0. 001], and 0 percent, respectively), normalization of alanine aminotransferase levels (48 percent [P < 0. 001], 55 percent [P < 0. 001], and 16 percent, respectively), and HBeAg seroconversion (12 percent [P = 0. 049], 14 percent [P = 0. 01], and 6 percent, respectively).