Document Classification

Section Type: RESULTS

Text: Compared with placebo, R10 and R40 significantly decreased the plasma levels of total sphingolipids including those of ceramide (-33 % and -37 %), sphingomyelin (-27 % and -31 %), monohexosylceramide (-40 % and -47 %), dihexosylceramide (-31 % and -34 %), and trihexosylceramide (-29 % and -31 %), and GM3 gangliosides (-29 % and -26 %), lysophosphatidylcholine (-32 % and -37 %), alkylphosphatidylcholine (-19 % and -19 %), phosphatidylcholine (-17 % and -19 %), alkenylphosphatidylcholine (plasmalogen) (-20 % and -22 %), alkylphosphatidylethanolamine (-20 %, P =. 008 and -24 %, P =. 02), alkenylphosphatidylethanolamine (plasmalogen) (-24 %, P =. 003 and -23 %, P =. 007), phosphatidylglycerol (-24 %, P =. 07, -31 %, P =. 046), and phosphatidylinositol (-34 % and -40 %).