Document Classification

Section Type: METHODS

Text: Between 1977 and 1983, 1146 premenopausal patients who had tumors > 5 cm or positive axillary lymph nodes were assigned randomly to 1 of 4 options : no systemic therapy, levamisole 5 mg weekly for 48 weeks (the levamisole arm), oral cyclophosphamide 130 mg/m (2) on Days 1 through 14 every 4 weeks for 12 cycles (the C arm), or oral cyclophosphamide 80 mg/m (2) on Days 1 through 14 plus methotrexate 30 mg/m (2) and fluorouracil 500 mg/m (2) intravenously on Days 1 and 8 every 4 weeks for 12 cycles (the CMF arm).