Document Classification

Section Type: RESULTS

Text: Over 12 months, metformin was associated with less weight gain than placebo [mean 6. 1 kg vs. 7. 6 kg ; adjusted difference 1. 5 kg (95 % confidence interval 0. 2-2. 9) ; P = 0. 02], a greater reduction in HbA1c [1. 5 % vs. 1. 3 % ; adjusted difference 0. 5 % (0. 1-0. 9) ; P = 0. 02] and a lower insulin requirement [62 units vs. 86 ; adjusted difference 25 units (15-34) ; P < 0. 001], but also more hypoglycaemia [relative risk of any episode 1. 24 (1. 02-1. 1) ; P = 0. 03].