Document Classification

Section Type: RESULTS

Text: Of all-grade adverse events that occurred in 5 % or more of patients, paraesthesia (61 [47 %] events in 131 patients in the FOLFOX group vs three [2 %] in 128 patients in the cisplatin-fluorouracil group, p < 00001), sensory neuropathy (24 [18 %] vs one [1 %], p < 00001), increases in aspartate aminotransferase concentrations (14 [11 %] vs two [2 %], p = 0002), and increases in alanine aminotransferase concentrations (11 [8 %] vs two [2 %], p = 0012) were more common in the FOLFOX group, whereas serum creatinine increases (four [3 %] vs 15 [12 %], p = 0007), mucositis (35 [27 %] vs 41 [32 %], p = 0011), and alopecia (two [2 %] vs 12 [9 %], p = 0005) were more common in the fluorouracil and cisplatin group.