Document Classification

Section Type: RESULTS

Text: The peak plasma concentration (C (max)) significantly decreased by 37. 5 % + / - 13. 3 % (P =. 001) in CYP2C19 * 2/CYP2C19 * 2 or * 3 and by 49. 6 % + / - 20. 7 % (P =. 017) in CYP2C19 * 1/CYP2C19 * 1 ; the area under the concentration-time curve extrapolated to infinity [AUC (0 - infinity)] decreased by 37. 9 % + / - 21. 3 % (P =. 014) and 43. 9 % + / - 23. 7 % (P =. 011) in CYP2C19 mutant and wild genotypes, respectively.