Document Classification

Section Type: METHODS

Text: After resection of T3-4, N0, M0 or T1-4, N1, 2M0 rectal adenocarcinoma, 1, 917 patients were randomly assigned to arm 1, with bolus FU in two 5-day cycles every 28 days before and after radiotherapy (XRT) plus FU via protracted venous infusion (PVI) 225 mg/m2/d during XRT ; arm 2 (PVI-only arm), with PVI 42 days before and 56 days after XRT + PVI ; or arm 3 (bolus-only arm), with bolus FU + leucovorin (LV) in two 5-day cycles before and after XRT, plus bolus FU + LV (levamisole was administered each cycle before and after XRT).