Document Classification

Section Type: RESULTS

Text: The amlodipine-atorvastatin combination, in addition to the expected hypocholesterolemic effect, produced : 1) a greater decrease in PAI-1 activity (-10. 2 U/mL, P <. 01 v placebo) and an even greater increase in t-PA activity (+0. 26 U/mL, P <. 01 v placebo) than amlodipine (-0. 5 U/mL for PAI-1, P = not significant ; +0. 17 U/mL for t-PA, P <. 01 v placebo) and atorvastatin alone (respectively, -9. 9 U/mL, P <. 01 v placebo and +0. 08 U/mL, P <. 05 v placebo) ; and 2) a greater systolic BP/diastolic BP mean reduction (-22 / 17 mm Hg, P <. 005 v placebo) than amlodipine (-18 / 14 mm Hg, P <. 01 v placebo) and atorvastatin alone (-2. 8 / 3. 8 mm Hg, P <. 05 v placebo only for diastolic BP).