Document Classification

Section Type: RESULTS

Text: After administration of candoxatrilat, plasma atrial natriuretic factor rose from 12. 8 + / -1. 6 (mean + / - SEM) to 44. 1 + / -6. 8 pmol/L (P < 0. 001) in association with a threefold increase in urine cGMP excretion (573 + / -195 pmol/min baseline to 1823 + / -545 pmol / min ; P < 0. 001), marked natriuresis (207 + / -34 micromol/min baseline to 416 + / -62 micromol/min ; P < 0. 001), fractional sodium excretion (3. 3 + / -0. 5 % baseline to 5. 6 + / -0. 7 % ; P < 0. 01), and diuresis (3. 4 + / -0. 5 ml/min baseline to 7. 4 + / -1 ml/min ; P < 0. 001).