Document Classification

Section Type: METHODS

Text: In an open-label, randomized, four-period, four-treatment, cross-over study, 24 healthy volunteers were given one dose of each of the following treatments, with a 7-day wash-out between dosing periods : Treatment A : two 100-mg trovafloxacin tablets given orally with 240 mL water ; Treatment B : two crushed 100-mg trovafloxacin tablets suspended in water and administered through a nasogastric tube into the stomach ; Treatment C : two crushed 100-mg trovafloxacin tablets suspended in water and administered through a nasogastric tube into the duodenum ; or Treatment D : two crushed 100-mg trovafloxacin tablets suspended in water and given through a nasogastric tube into the stomach concomitantly with an enteral feeding solution (240 mL full-strength Osmolite).