Document Classification

Section Type: RESULTS

Text: The mean values of the pharmacodynamic parameters of apparent zero-order rate constant for the flare or wheal spontaneous appearance (k (in)), the first-order rate constant for the flare or wheal disappearance, the mizolastine concentration that produced 50 % suppression of the maximum attainable inhibition of k (in), and the maximum attainable inhibition of the effect production were 14. 1 cm2/h (coefficient of variation [CV], 32 %), 0. 68 h (-1) (CV, 24 %), 21. 1 ng/mL (CV, 77 %), and 0. 92 (CV, 8 %), respectively, for the flare and 1. 9 cm2/h (CV, 64 %), 0. 63 h-1 (CV, 39 %), 43. 9 ng/mL (CV, 68 %), and 0. 87 (CV, 12 %), respectively, for the wheal inhibition.