Document Classification

Section Type: RESULTS

Text: AMG 145 significantly reduced LDL-C concentrations in all dose groups (mean baseline LDL-C concentration 37 mmol/L [SD 06] ; changes from baseline with every 2 weeks AMG 145 70 mg -410 % [95 % CI -462 to -358] ; 105 mg -439 % [-490 to -387] ; 140 mg -509 % [-562 to -457] ; every 4 weeks AMG 145 280 mg -390 % [-441 to -340] ; 350 mg -432 % [-483 to -381] ; 420 mg -480 % [-531 to -429] ; placebo every 2 weeks -37 % [-90 to 16] ; placebo every 4 weeks 45 % [-07 to 98] ; and ezetimibe -147 % [-186 to -108] ; p < 00001 for all doses vs placebo or ezetimibe).