Document Classification

Section Type: RESULTS

Text: In patients with a listed medical history of hypertension (n = 1, 464), least-squares mean (LSM [standard error (SE)]) changes from baseline to endpoint with placebo, tapentadol ER, and oxycodone HCl controlled release (CR), respectively, were -0. 7 (0. 44), 0. 2 (0. 43), and -0. 9 (0. 45) beats per minute (bpm) for heart rate ; -2. 4 (0. 64), -2. 7 (0. 64), and -3. 7 (0. 67) mmHg for SBP ; and -1. 0 (0. 39), -1. 3 (0. 39), and -2. 3 (0. 41) mmHg for DBP ; in patients with at least one listed concomitant antihypertensive medication (n = 1, 376), the LSM (SE) changes from baseline to endpoint were -0. 6 (0. 45), 0. 1 (0. 44), and -0. 7 (0. 47) bpm for heart rate ; -1. 8 (0. 66), -3. 3 (0. 65), and -3. 7 (0. 69) mmHg for SBP ; and -0. 7 (0. 40), -1. 4 (0. 40), and -2. 3 (0. 42) mmHg for DBP.