Document Classification

Section Type: RESULTS

Text: Compared with mean anakinra clearance (CL/F) after subcutaneous administration in the group with normal renal function (170 + / - 37 mL/min), CL/F was reduced by 16 % in the mildly impaired group (142 + / - 59 mL/min), by 50 % in the moderately impaired group (84. 5 + / - 24. 7 mL/min, P <. 05), by 70 % in the severely impaired group (51. 5 + / - 8. 4 mL/min, P <. 05), and by 75 % in the group with end-stage renal disease (42. 7 + / - 4. 7 mL/min, P <. 05).