Document Classification

Section Type: METHODS

Text: Patients were randomized to receive (G-CSF +) or not receive (G-CSF -) prophylactic G-CSF, 5 microg/kg/d, from day 7 until an absolute neutrophil count > or = 500/microL was sustained over 48 hours, after two consecutive induction courses of cyclophosphamide 1. 5 or 3 g/m (2), vincristine 2 mg/m (2), prednisone 60 mg/m (2) / d x 5, doxorubicin 60 mg/m (2), high-dose methotrexate 3 or 8 g/m (2), and intrathecal injections (COPAD [M]) on protocols LMB89, LMT89, and HM91 of the French Society of Pediatric Oncology.