Document Classification

Section Type: RESULTS

Text: Terminal half-life was approximately 4 h. For pharmacodynamics, we obtained : S = -0. 201 + / -0. 057 beats min-1 / ng ml-1 for HR, S = 0. 526 + / -0. 114 ms/ng ml-1 for PR interval duration, Emax = 42 + / -6 %, CE50 = 8. 8 + / -7. 2 ng ml-1 and gamma = 2. 2 + / -1. 5 for BAF, and Emax = -28 + / -4 %, CE50 = 5. 8 + / -5. 1 ng ml-1 and gamma = 3. 4 + / -1. 8 for BVR.