Document Classification

Section Type: RESULTS

Text: Valaciclovir pharmacokinetic parameters (mean + / - SD) in children who received tablets and suspension (normalised to 500 mg dose) were : maximum serum concentration (C (max)) 3. 16 + / - 1. 30 and 2. 42 + / - 0. 74 mg/L, time to maximum serum concentration (t (max)) 1. 88 + / - 0. 99 and 1. 31 + / - 0. 53 hours, half-life (t 1/2) 1. 72 + / - 0. 41 and 1. 94 + / - 0. 60 hours, apparent total systemic clearance (CL/F) 20. 01 + / - 6. 61 and 15. 58 + / - 3. 34 ml/min/kg, volume of distribution/bioavailability (Vd/F) 3. 04 + / - 1. 26 and 2. 58 + / - 0. 81 L/kg, and area under the concentration-time curve (AUC) 10. 13 + / - 3. 47 and 8. 59 + / - 2. 52 mg x h/L, respectively.