Document Classification

Section Type: RESULTS

Text: The final model describing the biexponential disposition of methotrexate was clearance (CL, 1 h (-1)) = (0. 0810 * BW + 0. 257 * CL (CR)) * (1 - (0. 167 * GEN) ; central volume (Vc, 1) = 0. 311 * BW ; peripheral volume (Vp, 1) = 0. 469 * BW-0. 169 * AGE ; intercompartmental clearance (Q, 1 h (-1)) = 4. 27 * (1-0. 355 * GEN) ; oral absorption rate constant (ka (p. o.), h (-1)) = 4. 70-0. 0439 * DOSE * (1-0. 507 * FED) ; intramuscular absorption rate constant (ka (i. m.), h (-1)) = 0. 122 * DOSE ; relative bioavailability (F) = 93. 4 % ; and oral absorption lag time (LAG (p. o.), min) = 13. 5.