Document Classification

Section Type: RESULTS

Text: Plasma drug concentration-versus-time curves suggested comparable terminal half-lives (mean [SD] values were 16. 5 [4. 44] and 14. 4 [3. 22] hours for armodafinil and modafinil, respectively) but higher systemic exposure with armodafinil than modafinil (mean [SD] AUC (0 -) values were 108. 8 [31. 66] and 66. 4 [20. 06] microg h/mL for armodafinil and modafinil, respectively), as indicated by the high geometric mean ratios for the AUC (the AUC (0 -)) ratio after a single dose was 1. 64 [95 % CI, 1. 60-1. 68 ; P < 0. 001], and the AUC (0 -) ratio after multiple doses was 1. 69 [95 % CI, 1. 65-1. 72 ; P < 0. 001]) and, to a lesser extent, the ratio of the maximum plasma drug concentration after multiple doses (C (max) ratio = 1. 37 [95 % CI, 1. 33-1. 41 ; P < 0. 001]).