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Section Type: RESULTS

Text: The pharmacokinetic parameters of erythromycin were as follows : Low dose group : Ka (1. 410 + / - 0. 626) / h, tmax (1. 8 + / - 0. 5) h, Cmax (197. 5 + / - 227. 6) microLg/L, AUC0-14 (766. 4 + / - 981. 0) microg x h/L, Ke (0. 519 + / - 0. 240) / h, T1/2 (1. 6 + / - 0. 8) h. Middle dose group : Ka (1. 900 + / - 1. 049) / h, tmax (1. 6 + / - 0. 2) h, Cmax (488. 3 + / - 216. 7) microg/L, AUC0-14 (488. 3 + / - 216. 7) microg/L, Ke (0. 329 + / - 0. 057) / h, T1/2 (2. 2 + / - 0. 4) h ; High dose group : Ka (1. 934 + / - 0. 794) / h, tmax (1. 7 + / - 0. 3) h, Cmax (749. 3 + / - 387. 2) microg/L, AUC0-14 (3820. 1 + / - 1966. 4) microg x h/L, Ke (0. 373 + / - 0. 174) / h, T1/2 (2. 2 + / - 0. 7) h. AUC of both erythromycin propionate and erythromycin base was linearly correlated to the doses ; T1/2 was not correlated to the doses, so they followed the first order processes.