Document Classification

Section Type: RESULTS

Text: It was found that 4 week of treatment with ipratropium bromide solution in patients with COPD led to the following : (1) a significant (p = 0. 05) improvement in mean nocturnal SaO2 with the more severe the nocturnal desaturation, the greater the improvement in SaO2 ; (2) significant (p = 0. 03) improvement in perceived sleep quality (VAS : 5. 5 + / - 0. 5 after placebo ; 7. 2 + / - 0. 5 after ipratropium) ; (3) a significant (p = 0. 05) increase in REM sleep time (48. 6 + / - 6. 3 min after placebo ; 66. 5 + / - 6. 4 min after ipratropium) with no effect on other sleep stages or total sleep time ; and (4) a significant (p = 0. 01) increase in pre-sleep FVC and flow rate at 50 % of the vital capacity.