Document Classification

Section Type: METHODS

Text: Patients were randomly assigned to receive intravenously either : CPT-11 125 mg/m (2), FA 20 mg/m (2) followed by 5-FU 500 mg/m (2) bolus, weekly for 4 weeks (arm A, Saltz regimen) ; or CPT-11 180 mg/m (2) day 1 then FA 200 mg/m (2) over 2 h and 5-FU 400 mg/m (2) bolus and 5-FU 600 mg/m (2) 22-h infusion on days 1 and 2, every 2 weeks (arm B, Douillard regimen) ; or CPT-11 350 mg/m (2) (days 1 and 43) alternating with FA 20 mg/m (2) / day followed by 5-FU bolus 425 mg/m (2) / day during 5 days (days 22-26) (arm C, Mayo Clinic regimen).