Document Classification

Section Type: RESULTS

Text: rs10273424, which maps approximately 50 kb centromeric to the cytochrome P450 3A (CYP3A) gene cluster at chromosome 7q22. 1, was associated with a 21. 8 % reduction in E1G levels (95 % confidence interval [CI] = 27. 8 % to 15. 3 % reduction ; P = 2. 7 10 (-9)) and a modest reduction in the risk of breast cancer in case patients who were diagnosed at or before age 50 years (odds ratio [OR] = 0. 91, 95 % CI = 0. 83 to 0. 99 ; P =. 03) but not in those diagnosed after age 50 years (OR = 1. 01, 95 % CI = 0. 93 to 1. 10 ; P =. 82).