Document Classification

Section Type: RESULTS

Text: The 2 models were used to simulate the arterial concentrations required for the pharmacodynamic models of sedation (Bispectral Index and Modified Observer 's Assessment of Alertness/Sedation [MOAA/S]) and gave population mean pharmacodynamic parameters as follows : Bispectral Index-IC (50) : 0. 26, 0. 07 g/mL ; : 1. 6, 8. 6 ; k (e0) : 0. 14, 0. 053 min (-1) ; I (MAX) : 39, 19, and MOAA/S-IC (50) : 0. 4, 0. 08 g/mL ; : 1. 4, 3. 4 ; k (e0) : 0. 25, 0. 050 min (-1) for remimazolam and midazolam, respectively.