Document Classification

Section Type: METHODS

Text: A sample size of 86 patients (21-22 / arm) was calculated under the hypothesis that the addition of capecitabine or VPA to SCRT can improve the TRG1 rate from 5 % to 20 %, with one-sided alpha = 0. 10 and 80 % power. Several biomarkers will be evaluated comparing normal mucosa with tumor (TP, TS, VEGF, RAD51, XRCC1, Histones/proteins acetylation, HDAC isoforms) and on blood samples (polymorphisms of DPD, TS, XRCC1, GSTP1, RAD51 and XRCC3, circulating endothelial and progenitors cells ; PBMCs-Histones/proteins acetylation).