Document Classification

Section Type: RESULTS

Text: Bortezomib systemic exposure was equivalent with subcutaneous versus intravenous administration in MMY-3021 [mean area under the plasma concentration-time curve from time zero to the last quantifiable timepoint (AUC (last)) : 155 vs. 151 ngh/mL ; geometric mean ratio 0. 992 (90 % CI 80. 18, 122. 80)] and comparable in CAN-1004 (mean AUC (last) : 195 vs. 241 ngh/mL) ; maximum (peak) plasma drug concentration (C (max)) was lower with subcutaneous administration in both MMY-3021 (mean 20. 4 vs. 223 ng/mL) and CAN-1004 (mean 22. 5 vs. 162 ng/mL), and time to C (max) (t (max)) was longer with subcutaneous administration in both studies (median 30 vs. 2 min).