Document Classification

Section Type: RESULTS

Text: Ketoconazole administration was associated with a decrease in imipramine apparent oral clearance (from 1. 16 + / - 0. 21 to 0. 96 + / - 0. 20 l h-1 kg-1, mean + / - s. d.; P < 0. 02), a prolongation in imipramine half-life (from 16. 7 + / - 3. 3 to 19. 2 + / - 5. 4 h, P < 0. 05) and a decrease in area under the curve of metabolically derived desipramine (from 3507 + / - 1707 to 3180 + / - 1505 nmol l-1 h, P < 0. 05), whereas concentrations of 2-hydroxy-imipramine were unaffected.