Document Classification

Section Type: METHODS

Text: One hundred fifty-nine patients with advanced colorectal carcinoma previously untreated for the metastatic disease (34 of them previously exposed to adjuvant 5-FU) were randomly allocated to receive : CPT-11, 200 mg/m2 i. v. on day 1, followed on day 2 by LFA, 250 mg/m2 i. v. infusion and 5-FU, 850 mg/m2 s i. v. bolus (arm A) ; TOM, 3 mg/m2 i. v. on day 1, followed on day 2 by LFA, 250 mg/m2 i. v. infusion and 5-FU, 1050 mg/m2 i. v. bolus (arm B) ; or MTX, 750 mg/m2 i. v. on day 1, followed on day 2 by LFA, 250 mg/m2 i. v. infusion and 5-FU, 800 mg/m2 i. v. bolus (arm C).