Document Classification

Section Type: RESULTS

Text: In Cox multivariable analyses with adjustment for the known predictive value of in-treatment ECG left ventricular hypertrophy by Cornell product and Sokolow-Lyon voltage, in-treatment systolic and diastolic pressure, randomized treatment, and standard cardiovascular risk factors, development of new ECG strain was independently associated with increased risks of cardiovascular death (hazard ratio [HR] 2. 42, 95 % confidence interval [CI] 1. 56 to 3. 76), myocardial infarction (HR 1. 95, 95 % CI 1. 11 to 3. 44), stroke (HR 1. 98, 95 % CI 1. 30 to 3. 01), the LIFE composite end point (HR 2. 05, 95 % CI 1. 51 to 2. 78), sudden cardiac death (HR 2. 19, 95 % CI 1. 06 to 4. 53), and all-cause mortality (HR 1. 92, 95 % CI 1. 37 to 2. 69), whereas the risk associated with regression or persistence of strain was attenuated.