Document Classification

Section Type: RESULTS

Text: After single-dose oral administration, the main pharmacokinetic parameters found for memantine at doses of 5, 10, and 20 mg were as follows : C (max), 6. 20 (0. 75), 11. 60 (1. 95), and 25. 34 (8. 34) ng/mL, respectively ; T (max), 5. 70 (1. 64), 6. 00 (1. 33), and 6. 89 (1. 41) h ; AUC (0-t), 486. 19 (80. 00), 889. 32 (239. 49), and 1772. 91 (784. 07) ng x h/mL ; AUC (0-infinity), 540. 05 (89. 68), 932. 07 (230. 82), and 1853. 29 (776. 85) ng x h/mL ; t (1/2), 66. 86 (11. 75), 63. 57 (12. 58), and 62. 06 (9. 26) h ; and MRT, 99. 37 (16. 96), 91. 73 (18. 16), and 89. 56 (13. 77) h.