Document Classification

Section Type: RESULTS

Text: Cimetidine significantly (p < 0. 05) increased the AUC [mean + / - s. d. (95 % C. I. of differences in mean)] for unchanged (+ / -) - nebivolol [7. 76 + / - 3. 07 ng ml-1 h with placebo ; 11. 50 + / - 5. 40 (1. 75, 8. 76) ng ml-1 h with cimetidine], (+) - nebivolol plus its hydroxylated metabolites [73. 0 + / - 18. 0 ng ml-1 h with placebo ; 91. 5 + / - 25. 7 (1. 0, 23. 1) ng ml-1 h with cimetidine] and (-) - nebivolol plus its hydroxylated metabolites [101 + / - 32 ng ml-1 h with placebo ; 123 + / - 38 (3. 3, 27. 0) ng ml-1 h with cimetidine].