Document Classification

Section Type: RESULTS

Text: Pharmacokinetic parameters (mean + / - SD) for SI piperacillin/sulbactam were : (1) peak serum concentration : piperacillin 231 + / - 66 mg/l, sulbactam 53. 1 + / - 15. 0 mg/l ; (2) minimum serum concentration : piperacillin 11. 5 + / - 14. 8 mg/l, sulbactam 4. 2 + / - 3. 5 mg/l ; (3) clearance : piperacillin 197 + / - 72 ml/min (CI 269 + / - 123 ml/min), sulbactam 167 + / - 61 ml/min (CI 212 + / - 109 ml/min) ; (4) half-life : piperacillin 2. 4 + / - 1. 2 h, sulbactam 3. 1 + / - 1. 6 h. Steady-state concentrations during CI were 25. 5 + / - 14. 5 mg/l for piperacillin and 8. 0 + / - 3. 7 mg/l for sulbactam.