Document Classification

Section Type: RESULTS

Text: In the ITT analyses, participants showed significant improvement in bowel symptoms as measured by the PAC-SYM (mean SD, -0. 28 0. 60, range : -1 -2. 33) and PAC-QOL (mean SD, 0. 33 0. 81, range : -1. 5 -2. 0) over time, but there were no significant differences between the lubiprostone and Senna groups in mean change in the PAC-SYM (-0. 20 0. 60 vs -0. 36 0. 61, P = 0. 61 respectively) or the PAC-QOL (0. 29 0. 76 vs 0. 37 0. 87, P = 0. 61 respectively).