Document Classification

Section Type: RESULTS

Text: Concurrent administration of ketoconazole with praziquantel significantly increased the mean area under the curve from time zero to infinity (AUC (0-alpha)) and maximum plasma concentration (Cmax) of praziquantel by 93 % (955. 94 + / - 307. 74 vs. 1843. 10 + / - 336. 39 ng h/mL ; P < 0. 01) and 102 % (183. 38 + / - 43. 90 vs. 371. 31 + / - 44. 63 ng/mL ; P < 0. 01), respectively, whereas the mean total clearance (Cl/F) of praziquantel was significantly decreased by 58 % (2. 65 + / - 0. 64 vs. 1. 11 + / - 0. 35 mL/h/kg ; P < 0. 01).