Document Classification

Section Type: RESULTS

Text: Compared to placebo, tibolone reduced serum concentrations of HDL-cholesterol (-14 %), HDL phosphatidylcholine (-14 %), apolipoprotein (apo) A-I (-12 %), HDL subclasses lipoprotein (Lp) A-I (-20 %), HDL-apoE (-16 %), pre beta-LpA-I (-10 %) and alpha-LpA-I (-12 %) and increased hepatic lipase activity (+25 %) and HDL sphingomyelin : phosphatidylcholine ratio (10. 5 %), but did not alter serum concentrations of HDL sphingomyelin, apoA-IV and LpA-I/A-II, lipoprotein lipase, the plasma activities of lecithin : cholesterol acyl transferase, cholesteryl ester transfer protein, phospholipid transfer protein or the plasma capacity to release cholesterol from cultured fibroblasts or Fu5AH hepatocytes.