Document Classification

Section Type: RESULTS

Text: Of the three treatments, the highest mean maximum plasma concentration (C (max)) and area under the plasma concentration-time curve (AUC) for saquinavir occurred with treatment B ; the lowest C (max) and AUC occurred with treatment A. Compared with treatment C (control), saquinavir 's bioavailability was 15. 9 % (90 % confidence interval [CI] 10-25 %) after treatment A and 167 % (90 % CI 106-265 %) after treatment B. Interindividual variability in both C (max) and AUC was slightly greater after treatments A and B than after treatment C. No correlation was found between pharmacokinetic parameters (C (max) and AUC) and gastric pH parameters, including maximum pH and pH at the time of drug delivery.