Document Classification

Section Type: RESULTS

Text: MSI-high status and SMAD4 focal loss of expression were identified as independent prognostic factors with better RFS (hazard ratio [HR] of recurrence = 0. 54, 95 % CI = 0. 37 to 0. 81, P =. 003) and OS (HR of death = 0. 43, 95 % CI = 0. 27 to 0. 70, P =. 001) for MSI-high status and worse RFS (HR = 1. 47, 95 % CI = 1. 19 to 1. 81, P <. 001) and OS (HR = 1. 58, 95 % CI = 1. 23 to 2. 01, P <. 001) for SMAD4 loss.