Document Classification

Section Type: RESULTS

Text: At 6 months after randomization, there was no significant difference in blood concentrations of markers of vascular inflammation (high-sensitivity C-reactive protein [P = 0. 32] ; soluble CD40L [P = 0. 33] ; IL-6 [P = 0. 77]), endothelial dysfunction (vascular cell adhesion molecule-1 [P = 0. 27] ; intercellular adhesion molecule-1 [P = 0. 08] ; von Willebrand factor [P = 0. 92]), and hypercoagulability (P-selectin [P = 0. 33] ; prothrombin fragment 1 and 2 [P = 0. 81] ; D-dimer [P = 0. 88]) among patients assigned vitamin therapy compared with placebo despite a 3. 7-micromol / L (95 % CI, 2. 7 to 4. 7) reduction in total homocysteine (tHcy).