Document Classification

Section Type: RESULTS

Text: The area under the plasma unbound phenytoin concentration-time curve (AUC (0, infinity) ; means (CAP, CEF) : 58. 5, 47. 6 micro g ml-1 h ; 95 % CI for difference between means : -35. 0, 11. 4), the peak unbound phenytoin concentrations (Cmax ; medians : 1. 12, 1. 29 micro g ml-1 ; 95 % CI : -0. 5, 0. 04), the times to Cmax (tmax ; medians : 4. 0, 4. 0 h ; 95 % CI : -2. 0, 3. 7), the CSF : plasma phenytoin ratios (means : 0. 21, 0. 22 ; 95 % CI : -0. 8, 0. 10), the fraction of phenytoin unbound (means : 0. 06, 0. 09 ; 95 % CI : -0. 01, 0. 07) and the cardiovascular parameters were not significantly different between CAP and CEF groups.