Document Classification

Section Type: RESULTS

Text: Compared with the placebo group (n = 47), histidine supplementation significantly decreased HOMA-IR (-1. 09 [95 % CI -1. 49, -0. 68]), BMI (-0. 86 kg/m [95 % CI -1. 55, -0. 17]), waist circumference (-2. 86 cm [95 % CI -3. 86, -1. 86]), fat mass (-2. 71 kg [95 % CI -3. 69, -1. 73]), serum NEFA (-173. 26 mol/l [95 % CI -208. 57, -137. 94]), serum inflammatory cytokines (TNF -, -3. 96 pg/ml [95 % CI -5. 29, -2. 62] ; IL-6, -2. 15 pg/ml [95 % CI -2. 52, -1. 78]), oxidative stress (superoxide dismutase, 17. 84 U/ml [95 % CI 15. 03, 20. 65] ; glutathione peroxidase, 13. 71 nmol/ml [95 % CI 9. 65, 17. 78]) and increased serum histidine and adiponectin by 18. 23 mol/l [95 % CI 11. 74, 24. 71] and 2. 02 ng/ml [95 % CI 0. 60, 3. 44] in histidine supplementation group (n = 45), respectively.