Document Classification

Section Type: RESULTS

Text: The values of the pharmacokinetic parameters of lamotrigine were : clearance over bioavailability (CL/F) 2. 60 + / -0. 40 l/h, renal clearance (CLR) 0. 10 + / -0. 03 l/h, terminal half-life (t1/2) 23. 8 + / -2. 1 h, mean peak serum concentration (Cmax) 0. 29 + / -0. 02 microg/l, time to reach Cmax (tmax) 1. 6 + / -0. 28 h, and total area under the serum concentration-time curve (AUC0-infinity) 703. 99 + / -82. 31 microg / ml/min (mean + / - SEM).