Document Classification

Section Type: METHODS

Text: Patients with locally advanced head and neck cancer were randomly assigned to receive radiotherapy delivered with : 1) standard fractionation at 2 Gy/fraction/day, 5 days/week, to 70 Gy/35 fractions/7 weeks ; 2) hyperfractionation at 1. 2 Gy/fraction, twice daily, 5 days/week to 81. 6 Gy/68 fractions/7 weeks ; 3) accelerated fractionation with split at 1. 6 Gy/fraction, twice daily, 5 days/week, to 67. 2 Gy/42 fractions/6 weeks including a 2-week rest after 38. 4 Gy ; or 4) accelerated fractionation with concomitant boost at 1. 8 Gy/fraction/day, 5 days/week and 1. 5 Gy/fraction/day to a boost field as a second daily treatment for the last 12 treatment days to 72 Gy/42 fractions/6 weeks.