Document Classification

Section Type: RESULTS

Text: USL255 fasted pharmacokinetic parameters [point estimate (90 % confidence interval, CI) compared to Topamax] were : relative bioavailability (F) 91. 2 % (84-99 %), peak plasma concentration (C (max)) USL255/Topamax-ratio 59 % (53-65 %), time to reach C (max) (t (max)) 19. 5 7. 2 h, accumulation ratio (R (ac)) 3. 9 1. 2, effective half-life (t (1/2, eff)) 55. 7 19. 9 h, terminal half-life (t (1/2, z)) 80. 2 14. 2 h, and peak-occupancy-time (POT) 12. 1 4. 0 h. Although the F and C (max) were unaffected by food, R (ac) and t (1/2, eff) increased to 4. 9 0. 9, and 72. 5 15. 4 h, respectively.