Document Classification

Section Type: METHODS

Text: Sequenom iPLEXTMGOLD Assay and MALDI-TOF platform were used to genotype the non-synonymous G2677T/A (rs2032582 ; encoding Ala893Ser/Thr) and synonymous C3435T (rs1045642 ; encoding Ile1145Ile) variants in ABCB1, the non-synonymous G1249A variant in ABCC2 (rs2273697 ; encoding Val417Ile), and the non-synonymous C421A variant in ABCG2 (rs2231142 ; encoding Q141K, Gln141Lys) in normal DNA from up to 511 women in Gynecologic Oncology Group (GOG) phase III trials, GOG-172 or GOG-182.