Document Classification

Section Type: RESULTS

Text: Rifampin reduced the total area under the plasma concentration-time curve (AUC) of unchanged atorvastatin (acid) by 80 % (95 % confidence interval [CI], 73 % to 84 % ; P <. 001), that of the active metabolites 2-hydroxyatorvastatin acid by 43 % (95 % CI, 29 % to 51 % ; P <. 001) and 4-hydroxyatorvastatin acid by 81 % (95 % CI, 74 % to 84 % ; P <. 001), and that of their lactones by 93 % (95 % CI, 90 % to 95 %), by 61 % (95 % CI, 50 % to 69 %), and by 76 % (95 % CI, 70 % to 81 %), respectively (P <. 001).