Document Classification

Section Type: RESULTS

Text: Response rates were significantly higher with 25 mg of naloxegol than with placebo (intention-to-treat population : study 04, 44. 4 % vs. 29. 4 %, P = 0. 001 ; study 05, 39. 7 % vs. 29. 3 %, P = 0. 02 ; patients with an inadequate response to laxatives : study 04, 48. 7 % vs. 28. 8 %, P = 0. 002 ; study 05, 46. 8 % vs. 31. 4 %, P = 0. 01) ; in study 04, response rates were also higher in the group treated with 12. 5 mg of naloxegol (intention-to-treat population, 40. 8 % vs. 29. 4 %, P = 0. 02 ; patients with an inadequate response to laxatives, 42. 6 % vs. 28. 8 %, P = 0. 03).