Document Classification

Section Type: RESULTS

Text: Our main findings were : 1) gene expression of several chemokines (i. e., macrophage inflammatory protein [MIP] -1 alpha, MIP-1beta, and interleukin [IL] -8) and chemokine receptors (i. e., CC chemokine receptor [CCR] 1, CCR2, CCR4, and CCR5) was markedly increased among CAD patients compared with healthy control subjects ; 2) treatment with atorvastatin and simvastatin markedly reduced the mRNA levels of some of these chemokines (i. e., MIP-1alpha, MIP-1beta, IL-8) and receptors (i. e., CCR1 and CCR2), with the most pronounced effect in the atorvastatin group ; and 3) statin therapy reduced the spontaneous release of IL-8 and MIP-1alpha from PBMCs in CAD patients.