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38.37
48.21
36.77
32.69
33.72
32.17
28.93
22.93
36.08
57.21
66.45
62.76
58.04
52.31
73.06
61.74
19.04
13.41
19.65
10.91
12.81
14.56
28.81
25.71
25.45
72.73
59.17
5.26
6.83
12.85
11.54
11.09
10.2
6.02
7.87
7.52
10.59
7.78
8.08
7.44
5.27
5.89
4.94
6.98
9.09
7.31
5.25
12.68
12.06
11.48
12.43
5.45
9.27
6.6
7.96
41.94
32.15
16.76
39.98
30.16
22.82
21.63
22.82
22.5
33.2
20.61
17.13
38.51
19.5
45.88
26.41
20.87
33.72
27.04
20.69
24.88
16.96
21.5
27.27
23.74
23.79
16.54
16.06
31.2
22.17
25.89
45.48
48.43
21.31
31.1
28.6
25.92
24.51
22.12
19.59
25.65
24.67
26.42
27.25
27.2
26.39
42.87
40.67
45.17
22.92
29.63
24.42
17.83
6.54
45.01
26.14
29.27
27.19
25.46
17.33
36.25
22.03
36.72
40.02
33.86
24.38
22.76
24.67
16.36
16.61
17.27
14
15.02
14.35
14.47
6.92
16.45
11.16
10.65
12.78
10.7
7.49
8.09
10.4
14.22
7.16
12.34
13.11
7
28.49
28.85
35.06
30.36
28.39
36.74
33.26
36.05
33.11
30.56
39.41
34.01
33.14
28.32
30.18
25.74
35.06
34.16
32.59
30.39
31.89
33.56
31.83
38.2
39.41
29.87
33.76
31.32
15.99
16.43
16.5
17.34
23.6
20.12
17.08
10.99
28.1
16.72
16.36
19.57
26.68
24.16
16.93
18.51
8.72
17.01
16.48
10.5
14.67
10.66
15.67
19.31
13.54
15.69
13.99
9.95
13.32
12.7
15.32
13.92
13.4
18.85
22.51
15.91
9.96
14.27
14.18
13.93
14.88
17.55
17.04
20.22
14.56
14.6
14.62
18.05
13.3
13.86
13.44
10.25
10.14
9.19
6.74
8.15
5.57
76.04
41.84
81.41
89.96
27.38
64.18
8.86
27.25
28.62
19.21
16.16
23.04
42.74
57.89
47.62
28.09
29.15
18.86
16.91
46.38
24.17
23.04
21.67
14.52
26.83
16.62
13.88
16.19
18.86
15.71
53.48
88.15
3.3
15.25
27.75
10.92
13.93
5.91
24.45
12.73
5.91
20.63
72.31
73.65
51.96
52.88
63.47
61.9
58.28
56.7
41.4
45.01
71.78
68.75
8.98
9.42
13.34
12.92
22.97
19.88
9.8
7.51
34.73
22.9
6.89
19.14
7.46
10.67
11.34
14.28
17.79
5.12
30.2
24.25
25.08
28.46
23.02
20.05
23.4
25.34
17.75
21.65
27.17
30
17.63
23.83
22.87
15.17
19.66
25.28
23.17
34.4
19.19
25.27
35.02
20.99
16.66
18.27
16.02
24.21
77.33
64.17
20.44
26.83
21.24
29.6
26.47
40.89
42.6
33.53
17.06
47.44
59.25
22.42
29.68
21.28
33.41
17.03
24.15
10.77
42.09
71.04
30.49
33.14
27.06
31.91
18.66
29.3
23.72
42.05
34.96
22.75
9.47
10.89
11.74
13.19
17.13
13.41
4.64
20.54
7.94
9.3
8.02
9.39
9.41
8.95
8.86
7.78
9.12
9.06
6.43
6.82
9.24
6.72
9
9.34
9.77
9.22
15.09
14
15.36
22.5
22.24
22.12
23.12
31.69
26.74
35.41
40.49
32.44
34.42
35.43
14.3
14.6
6.34
0
5.07
20.87
19.03
18.4
12.06
13.38
14.17
23.98
21.56
23.98
43.73
48.21
43.81
12.06
12.41
11.2
38.93
45.54
39.84
57.13
51.36
58.57
10.44
9.33
8.58
22.19
21.26
21.49
18.54
22.53
23.38
25.75
8.62
22.8
38.32
6.61
16.97
20.85
34.03
30.09
38.97
50.45
9.55
15.76
36.87
21.25
18.24
19.46
18.74
44.79
49.02
18.27
21.33
59.3
31.63
25.21
110.48
29.35
30.43
34.8
6.9
10.2
11.89
10.72
15.03
12.32
14.07
15.95
13.49
9.93
9.77
9.93
25.02
20.31
19.06
29.03
20.48
19.74
23.03
18.3
16.15
36.5
36.16
43.35
44.66
11.14
20.76
10.39
8.41
12.32
13.5
15.05
15.08
23.06
10.59
12.39
4.85
3.1
27.82
3.13
6.72
37.89
16.23
20.43
10.88
26.87
31.14
5.06
26.41
13.43
9.51
6.02
32.89
32.09
21.3
37.05
43.41
59.13
49.15
26.45
50.23
57.28
2.95
20.09
20.64
19.39
23.48
39.81
33.08
30.02
31.64
39.27
10.1
25.37
0
18.03
27.42
29.93
19.06
22.2
25.88
24.13
100.13
107.27
12.73
18.86
43.46
22.4
36.1
38.7
36.84
35.93
33.62
34.19
165.84
134.43
165.15
43.09
48.9
18.59
122.44
119.34
110.5
38.14
34.25
35.94
26.35
42.31
36.34
37.96
35.1
37.62
25.6
29.72
27.78
30.21
30.12
203.07
33.71
65.92
102.92
86.07
125.18
22.91
15.4
88.89
21.36
53.8
42.78
72.6
48.01
35.29
25.13
61.75
39.31
49.21
34.67
33.85
16.21
16.46
13.54
9.96
5.33
8.26
5.19
15.81
17.53
9.01
4.29
12.59
11.7
7.88
13.33
12.59
2.77
4.57
9.95
22.24
11.54
8.45
6.57
9.19
11.58
45.27
10.97
5.59
8.76
9.34
7.17
3.19
3.17
5.93
6.56
1.24
3.11
0.53
5.03
3.89
6.84
2.49
0
0
1.91
5.16
4.92
50.93
54.59
10.08
12.65
8.48
22.18
15.36
6.11
6.31
10.6
16.28
18.06
20.43
11.9
8.53
12.13
44.77
38.94
40.27
51.33
22.16
17.46
34.71
24.83
29.74
34
29.74
6.64
13.79
9.25
14.89
32.29
31.63
43.12
36.15
65.17
23.18
23.28
39.41
18.45
17.01
20.3
18.28
31.12
13.28
19.12
20.34
13.45
27.83
36.63
22.74
12.82
33.69
14.29
14.24
39.48
11.36
30.04
31.45
27.94
35.73
25.77
14.06
22.49
42.59
32.67
17.18
16.07
22.2
136.72
126.02
115.61
134.58
150.84
142.76
125.86
162.98
107.25
74.24
76.98
72.2
74.06
52.61
79.39
102.56
70.71
76.06
52.9
82.21
74.74
68.99
70.35
68.48
69.1
105.04
98.74
85.95
94.26
141.76
147.23
140.41
139.68
81.43
90.35
80.08
86.82
80.77
104.09
107.54
102.57
106.8
82.69
94.16
94.06
93.33
93.11
129.46
125.27
130.74
129.89
87.01
93.21
85.28
74.15
125.02
141.42
138.47
114.46
89.29
69.61
161.85
137.94
70.31
113.35
109.54
103.96
60.73
62.32
81.47
85.55
85.53
95.53
85.61
73.35
76.08
74.29
160.71
171.64
174.12
134.34
136.08
136.62
68.86
72.55
72.84
110.84
117.77
114
108.65
98.45
112.16
113.41
99.06
104.29
59.12
69.34
60.66
58.02
67.29
60.71
79.87
84.98
88.75
85.68
84.12
87.21
41.61
41.15
38.52
58.81
50.33
46.79
47.57
47.99
47.65
29.75
42.16
36.09
36.89
61.99
57.49
62.14
88.96
86.49
88.19
85.55
90.53
86.62
79.12
70.11
81.38
87.36
90.93
84.18
52.13
56.01
82.49
62.47
44.67
78.62
51.08
41.91
75.83
110.85
116.93
104.27
103.78
91.01
148.88
108.99
113.2
109.37
121.26
87.61
110.94
104.93
96.6
120.53
124.39
121.42
115.32
119.46
158.03
129.67
116.41
141.55
121.19
112.84
134.81
119.44
118.8
138.46
67.1
68.82
124.81
133.12
124.43
73.42
62.21
120.02
87.41
84.58
121.69
131.99
138.54
52.68
54.91
115.51
74.57
71.25
127.21
162.63
158.5
74.86
71.73
95.7
99.26
82.66
80.15
181.15
172.41
93.93
91.02
96.09
101.82
76.37
75.11
162.09
166.12
77.76
80.06
82.5
69.54
61.57
91.65
143.37
128.96
73.18
70.1
59.85
55.44
53.25
56.13
52
45.4
40.03
42.24
36.27
39.43
37.98
44.62
31.52
39.35
34.75
32.68
19.42
40.35
38.79
33.61
53.42
79.25
40.06
60.78
73.88
72.64
75.34
99.2
166.54
108.33
96.71
79.33
69.98
134.43
87.26
110.43
97.57
105.69
108.49
149.78
67.5
72.69
57.74
135.64
116.85
147.94
62.11
231.32
131.77
116.28
192.63
216.11
210.68
167.83
162.29
142.08
138.64
151.5
148.56
143.14
144.29
121.41
123.99
90.1
95.08
107.5
111.56
99.11
96.24
89.66
93.08
135.91
138.44
79.66
114.18
93.51
94.56
104.86
89.33
69.68
68.91
102
86.64
82.88
195.07
176.88
177.68
88.42
91.53
78.64
89.47
98.39
100.84
99.38
99.1
96.54
91.13
92.55
96.49
97.37
73.07
98.77
97.04
75.73
96.46
17.62
16.42
16.02
21.61
59.3
55.18
27.98
29.43
30.96
115.96
96.87
125.58
86.41
76.74
72.11
69.05
76.29
67.21
142.39
120.64
110.94
95.37
94.83
68.94
89.15
78.93
73.87
88.57
87.67
80.16
71.41
72.18
91.2
72.01
76.14
63.54
87.35
88.3
57.29
77.64
73.51
79.06
66.2
54.1
76.66
80.24
69.93
78.54
81.65
83.39
91.26
85.91
84.2
97.98
102.01
83.19
94.93
92.51
73.88
71.73
77
90.07
52.2
52.07
49.78
33.22
34.67
68.89
63.92
95.45
95.24
100.74
107.75
104.39
103.74
105.83
81.91
75.68
110.38
99.56
74.31
89.86
68.08
75.88
64.57
60.97
58.92
59.71
55.94
73.19
48.21
40.08
44.91
82.31
81.05
84
104.21
106.57
101.93
102.61
105.58
100.25
90.3
85.86
83.87
42.83
48.29
45.55
72.7
75.27
69.23
79.68
96
76.35
65.36
88.31
110.65
58.09
85.78
75.44
96.86
87.82
47.86
55.19
74.11
80.49
51.48
81.9
70.67
88.13
80.35
86.67
46.37
94.38
62.01
84.43
56.34
96.76
103.78
106.32
77.35
80.95
80.96
97.18
97.05
99.36
97.57
95.65
100.89
79.5
83.21
82.92
77.47
71.59
65.65
74.54
71.02
66.41
78.86
81.33
74.04
120.64
118.16
132.3
67.12
47.16
35.21
41.44
20.09
22.97
25.58
30.9
61.3
78.78
26.47
23.08
6.58
24.23
79.16
27.53
16.99
51.33
48.45
62.2
57.69
39.29
34.71
33.8
16.83
36.86
47.57
31.39
28.28
23.72
32.42
18.04
63.92
72.1
47.61
52.19
63.26
46.16
39.67
46.11
44.15
36.28
66.65
59.94
68.56
56.14
70.07
79.71
73.57
89.26
41.54
48.28
134.25
151.17
84.19
85.66
64.79
66.59
27.48
39.8
91.63
70.86
88.77
70.9
55.77
54.54
60.5
57
55.46
55.46
103.47
85.48
108.84
49.56
50.68
72.45
27.01
26.73
41.75
52.5
69.97
52.44
77.78
57.57
56.66
55.25
64.51
57.6
63.32
74.21
78.06
57.42
60.92
82.5
120.31
76.3
95.63
92.02
94.28
104.2
104.99
91.97
103.24
118.77
97.73
100.52
117.26
151.6
81.05
101.34
112.56
90.61
127.58
118.97
83.28
56.97
62.22
57.72
71.71
68.49
64.24
61.37
62.42
71.67
66.68
65.79
68.83
72.92
66.84
67.11
64.61
75.16
74.41
70.97
64.8
68.24
65.78
70.91
64.64
63.15
68.4
69.35
63.06
66.48
81.12
66.81
64.59
68.17
77.31
84.35
109.48
95.28
96.06
108.65
118.42
96.08
107.82
48.57
95.1
102.2
97.86
135.43
108.34
93.42
86.26
90.15
131.04
126.41
94.51
106.47
100.69
108.72
107.04
108.21
96.65
87.43
91.83
133.21
134.53
103.41
99.54
124.56
66.82
67.4
65.57
84.8
68.26
77.17
57.48
65.31
49.97
78.13
71.61
80.62
79.44
58.05
85.15
79.19
74.38
79.97
64.57
70.03
70.41
63.51
67.51
65.08
65.17
68.57
64.23
85.1
88.15
87.86
68.47
70.32
74.53
71.76
70.32
90.47
69.6
83.83
69.89
70.34
76.05
70.51
76.01
74.65
73.23
68.08
68.63
79.95
0.31
0.56
0
0
0.08
0.23
0.3
1.47
0.45
0.55
0.53
0.54
0.44
1.38
0.17
0
0.29
0.07
0.22
0.04
0.07
0.04
0.64
0.12
0.21
0.09
0
0.02
0
0.02
0.06
0.02
0
0.04
0.08
0
0
0.05
0.06
0
0.06
0.09
0.04
0
0.06
0
0
0.02
0.05
0
0.05
0
0.05
0.02
0.03
0.6
1.37
3.74
0
0.32
0.19
0.21
0.4
1.33
0.85
0
0.8
0
0
0
0
0
0
0.33
0.1
0.19
0
0.22
0.65
0
0.41
0.41
0.42
2.37
2.04
1.74
2.59
0.86
2.66
0
0
0.4
0
0.41
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
3.15
0.29
0
0
0
0
0
0
2.65
3.16
4.08
0.47
0.74
0.29
0.01
0.06
0.02
0.02
0.05
0
0.02
0.21
0.17
0.04
0.02
0.12
0
0.06
0
0
0
0
0.03
0.08
0.06
0.16
0.01
0.2
0.18
0.13
0.04
0.08
0.17
0.08
0.09
0.23
0.15
0.08
0
0.27
0.12
0.13
0.18
0.06
0
0.13
0.21
0.03
0.06
0.06
0.12
0.05
0.1
0
0
0
0
0
0.08
0
0
0
0.11
0
0.16
0.07
0
0.09
0.04
0.61
0.25
0.24
0.74
0.1
0
0.03
0.04
0.33
0
0.44
0.08
0
0
0
0.07
0
0.04
0.48
0.06
0.08
0.25
0
0
0.2
0.53
0
0.59
0.02
0.11
0.73
0.57
0.08
0.17
0.04
0.08
0.23
0.12
0.28
0.4
0.16
1.36
1.2
1.51
2.68
1.63
1.4
3.95
1.29
1.58
2.8
1.87
1.46
1.9
1.27
2.26
1.43
1.15
1.43
0.37
0.15
1.54
4.7
6.26
16.84
13.12
7.97
2.89
7.17
0
0
0
0
0.28
0
0.72
0.94
0
0.29
0.29
0.37
0
0.05
0.06
0
0
0
0
0
0
0
0
0
0
0
0
0
0.9
1.26
2.48
2
0.11
0.03
1.16
0.56
2.08
2.36
0
0
0
0.54
0.12
0
0.05
0.28
0.26
0.29
0.14
0.34
0.31
0.37
0.15
0.13
0.24
0.1
0.32
0.33
0.42
0.47
0.12
0.43
0.08
0.44
0.29
0.14
0.34
0.33
0.91
0.83
0.44
1.37
0.03
0
0.42
0.19
0.49
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0.33
0
0
0.02
0.03
0.03
0.1
0.1
0.25
0.2
0
0.12
0
0.04
0.14
0.07
0.09
0
0.02
0.13
0.08
0.2
0.06
0.21
0
0.14
0.07
0.07
0.22
0.08
0.22
0.09
0
0.12
0
0.09
0.04
0
0.08
0.24
3.25
7.25
2.22
2.33
2.55
2.76
0.14
0.25
0.15
21.07
20.69
23.6
7.69
4.96
7.82
0.48
0.61
0.63
48.5
45.48
47.36
23.45
25.5
26.17
0.68
0.34
0.55
33.31
30.71
33.38
32.91
30.85
35.43
0
0
0
0
0
0
0
0
0
0
0
0.15
0
0
0
0
0
0
0
0
0.11
0
0
0
0
0.07
0
0
0
0.41
0.44
0.33
0.15
0.18
0.21
0.18
0.2
0.17
0.51
0.45
0.59
0.22
0.63
0.42
0.42
0.12
0.21
0.8
1.54
1.86
3.77
8.04
3.81
1.14
0.25
0
0.65
0.22
0.27
0.38
0.16
0
4.68
0
0.56
0
0
0
0
0
0
0
0
0
0
0
0
0.46
0.18
0
0.03
0.09
0
0.04
0.08
0.1
0
0
0.16
0
0.03
0
0
0
0
0
0
0.19
1.68
0
0.06
0.02
0.19
0
0
0.24
0.37
0.32
0
0.56
0.67
0.1
0.18
0
0
0.81
0
0
0.02
0.03
0.02
0
0.07
0
0.04
0
0.15
0.03
0
0
0
0
0.31
0.03
0.02
0
0.04
0.26
0.08
0.03
0.05
0
0.04
0.03
0.34
0.04
0
0
0.04
0.22
0.24
0.21
0.26
0.07
0.05
0
0
0.04
0
0
0.08
0
0
0
0
0
0
0
0.77
0.15
0.14
0.35
0.43
0.28
0
0
0.69
0
0.16
0.41
0
0.54
1.02
0.13
0.22
0
0.68
0
1.14
0.4
0.23
0
0
0.48
0
0.77
0.23
0
0
0.39
0.31
0.21
0.12
0
0.5
0
0.08
0.25
0
0.06
0
0
0.27
0.1
0
0
0.06
0.03
0
0
0
0
0
0.17
0
0
0.04
0.07
0.04
0.08
0
0
0
0
0.05
0
0.23
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0.25
0
0
0
0
0
0
0.47
0
0
0
0
0
0
0
0
0
0
49.13
35.38
37.26
40.92
39.41
36.31
26.93
32.17
29.85
26.5
23.7
28.61
27.88
26.84
28.32
9.42
27.56
28.35
20.3
27.3
24.74
32.85
33.93
36.32
35.78
13.41
12.05
28.74
30.58
36.15
39.73
36.24
41.05
28.64
33.62
31.17
31.09
30.37
27.61
26.69
30.21
27.81
29.21
28.86
31.41
30.75
30.82
36.64
35.94
40.53
37.09
31.22
34.03
28.97
25.24
17.32
24.27
21.52
17.18
18.61
14.31
13.93
14.13
21.13
17.76
15.59
16.3
11.57
10.43
15.48
14.31
19.72
19.7
21.47
12.16
14.97
14.58
15
15.32
14.34
15.95
15.11
13.66
22.52
20.79
21.21
17.56
21.8
17.17
13.49
10.97
11.36
15.18
15.81
18.93
11.46
10.54
14.09
11.8
10.04
11.75
14.83
18.28
13.46
15.07
14.62
15.15
38.89
25.81
39.53
49.95
45.63
40.12
41.57
36.67
30.68
34.45
46.25
40.52
42.46
47.79
49.63
49.22
44.46
39.16
44.48
45.28
49.63
48.89
44.71
43.05
38.06
49.78
49.1
42.65
32.27
32.57
38.79
32.02
26.15
34.98
29.39
25.89
35.04
36.25
37.88
45.84
45.91
42.77
33.96
45.47
46.96
45.44
44.21
39.43
40.86
47.26
44.21
23.66
25.25
32.51
35.26
38.46
28
32.25
32.25
31.01
34.17
30.95
27.29
32.6
35.43
33.78
20.85
27.78
30.06
35.82
34.36
29.44
14.1
20.03
35.6
37.17
22.81
24.2
22.76
28.51
28.3
10.67
25.36
25.92
14.1
19.86
19.54
26.54
27.49
15.3
2.59
12.3
13.75
20.4
20.11
20.84
16.37
19.87
21.49
18.58
19.4
22.42
21.1
18.28
18.49
16.45
23.77
23.61
21.59
20.31
20.62
14.78
15.19
39.24
42.57
32.66
38.87
39.83
32.8
45.05
48.5
46.86
15.7
20.71
12.99
16.6
16.12
13.61
19.86
17.58
14.73
24.37
18.08
19.24
24.46
18.05
18.92
24.41
25.53
22.18
9.26
13.91
8.15
12.99
13.65
16.66
17.77
12.05
8.37
12.7
25.5
22.05
36.62
31.89
11.53
14.12
18.5
20.73
17.26
12.25
20.08
16.43
22.37
15.67
19.38
19.97
20.98
19.4
16.12
15.85
18.91
20.14
14.34
14.27
22.82
21.61
31.5
26.48
24.46
27.99
21.19
21.25
33.44
35.85
32.76
25.73
9.88
18.37
22.26
22.69
11.24
15.16
30.32
24.31
28.13
24.83
25.26
26.51
22.43
23.36
25.6
26.87
26.08
25.99
28.28
27.94
24.54
29.08
26.51
35.1
29.11
33.79
34.48
33.27
32.25
38.82
31.17
35.41
28.29
33.79
34.53
20.09
18.09
20.49
15.76
17.73
23.4
23.53
21.36
18.13
25.78
29.7
29.85
30.52
29.2
45.06
26.85
26.39
29.66
31.91
31.56
44.37
32.1
34.06
38.43
7.9
19.24
22.33
27.65
25.15
20.28
25.77
22.48
25.94
48.97
46.16
47.71
52.82
42.38
43.73
45.97
38.36
29.44
26.9
27.44
29.11
22.31
22.72
25.17
27.3
16.25
19.8
19.95
29.73
24
29.07
25.63
29.04
24.01
30.72
22.34
19.98
22.17
7.96
8.24
15.47
16.74
9.64
10.09
9.41
12.52
12.73
12.61
12.35
23.94
24.24
16.12
27.55
12.9
24.3
25.45
26.06
30.02
29.04
30.03
32.49
32.23
35.52
26.13
24.04
24.22
46.36
50.78
46.99
56.71
51.34
52.92
38.16
37.61
38.62
36.07
32.95
32.98
41.13
44.13
31.34
47.87
41.19
48.13
18.36
11.92
21.11
12.96
19.87
17.11
23.6
15.83
9.13
15.52
16.49
39.7
23.04
14.77
34.36
26.92
15.53
22.79
17.04
25.79
15.93
27.86
13.76
8.48
16.79
21.01
18.65
25.59
15.96
41.88
44.27
45.72
33.12
35.05
34.97
30.49
29.38
31.14
41.85
40.07
38
27.68
31.6
30.56
29.53
29.87
28.24
26.79
27.28
27.05
36.15
43.96
32.38
12.27
11.4
10.03
10.88
7.49
4.97
7.34
11.67
17.11
13.36
10.45
7.89
1.62
5.98
15.5
4.53
12.67
32.49
33.1
26.14
31.36
24.86
19.65
27.36
24.62
28.13
18.24
34.14
25.26
24.22
20.16
17.86
25.54
26.48
15.23
30.5
17.57
21.52
13.5
15.33
16.75
15.27
17.81
22.21
24.62
27.83
30.2
20.33
22.83
24.57
11.01
24.98
21.94
22.87
32.05
32.7
26.13
28.84
9.84
13.14
24.66
32.52
30.88
32.96
23.29
22.79
19.88
22.39
22.01
21.86
15.21
15.78
11.72
20.59
21.94
30.03
16.77
16.92
38.24
21.11
22.79
24.51
32.03
20.41
18.63
22.9
24.02
21.27
23.34
28.55
31.67
21
22.72
29.91
21.18
20.19
25.57
24.3
26.15
19.52
18.82
22.53
18.56
20.47
19.12
17.73
23.66
21.35
20.71
22.07
30.42
13.63
27.89
20.66
16.6
45.14
51.46
42.34
40.9
42.4
46.83
45.7
47.38
38.78
51.04
53.39
47.87
45.99
47.01
49
52.19
50.02
47.83
43.68
44.53
39.03
42.47
44.49
52.46
45.58
46.02
48.15
49.01
43.67
49.07
48.95
45.77
50.08
49.55
18.97
25.84
16.38
15.62
18.82
22.53
25.27
25.6
5.46
18.75
22.69
21.28
17.7
13.82
26.73
24.7
27.01
20.38
27.02
14.28
28.28
28.77
36.11
34.73
34.54
31.86
29.57
29.19
18.18
18.42
15.24
13.2
23.97
44.86
45.92
47.78
39.78
38.95
42.28
35.34
39.76
31.65
44.59
44.6
39.38
41.98
17.37
29.06
37.9
36.2
38.87
47.83
44.73
49.33
48.62
46.86
44.57
37.22
37.26
35.13
40.43
36.61
42.5
49.63
43.73
44.04
40.22
39.68
38.94
42.57
40.7
41.5
44.01
42.91
44.75
35.41
40.09
41.45
26.96
31.8
26.49
26.25
35.33
31.06
35.58
32.7
37.74
40.85
58.86
56.97
57.5
63.89
57.74
44.38
47.37
53.55
39.17
22.88
21.48
33.02
19.53
20.72
15.44
25.56
20.82
20.88
35.06
35.34
22.36
22.58
42.11
42.46
38.66
40.18
25.52
42.11
40.1
44.87
42.3
17.22
17.08
17.38
17.43
23.94
9.72
9.26
9.48
8.74
38.55
36.42
38.36
36.39
21.64
22.32
26.76
31.27
111.58
93.1
92.86
111.3
111.34
117.75
63.22
45.29
68.69
93.44
97.8
72.3
94.52
80.88
65.77
95.46
116.66
123.22
119.33
116.21
114.2
123.55
65.75
59.95
58.4
36.4
38.39
38.49
65
72.81
68.07
98.08
106.54
94.93
97.6
102.47
104.26
78.41
74.53
78.83
91.62
97.25
94.5
86.34
78.1
79.07
73.56
67.36
66.5
103.98
102.69
92.87
5.82
4.06
30.56
29.8
3.48
6.46
4.49
4.19
7.87
2.89
28.18
28.29
30.49
29.8
25.99
27.75
17.91
19.22
17.05
18.54
18.07
19.26
15.73
12.36
15.1
16.09
14.97
13.24
17.02
23.61
15.47
20.17
25.17
19.15
23.82
31.35
19.03
71.25
70.15
62.79
59.55
51.08
49.9
58.86
59.75
53.35
51.03
52.59
53.96
45.38
48.66
86.76
72.55
50.93
49.94
65.49
60.39
63.1
56.48
55.08
58.87
54.89
61.47
55.7
57.01
69.05
75.53
62.68
67.52
50.88
52.51
62.07
76.49
68.67
47.15
47.13
66.3
48.9
53.16
57.42
54.46
76.58
64.16
61.38
70.16
57.99
57.57
66.39
67.58
52.43
57.83
81.26
87.36
27.47
23.75
65.17
65.5
52.05
54.58
82.59
88.91
26.57
28.39
77.97
78.89
61.12
69.43
75.06
58.49
29.23
32.1
69.82
73.23
11.5
11.05
11.5
12.39
11.69
10.02
8.76
8.33
8.31
85.86
43.88
79.03
91
36
72.27
118.28
109.9
129.51
77.09
86.07
95.09
71.34
44.71
50.58
49.78
31.55
35.05
0.29
0
0.73
0.49
0.68
1.75
1.3
1.79
1.12
0.86
22.13
20.76
23.48
27.51
51.82
38.54
62.6
36.94
38.8
33.87
48.59
50.25
43.43
55.08
25.77
26.8
28.51
28.58
26.45
26.6
25.63
28.77
24.71
23.08
37.09
33.66
20.64
21.92
67.65
65.58
51.18
49.2
19.26
18.33
47.07
48.87
60.77
58.55
23.01
22.04
75.17
74.75
94.71
98.88
78.62
73.15
74.58
28.23
23.5
25.58
72.2
72.71
67.86
79.57
82.71
81.6
61.94
69.55
70.39
17.86
19.74
17.45
18.43
24.52
17.74
21.17
23.59
19.95
61.35
62.62
54.65
52.27
103.31
83.78
122.89
104.41
77.37
34.04
25.86
29.33
65
55.74
49.99
80.56
73.85
81.17
22.53
21.57
35.85
26.57
16.92
18.34
35.3
33.68
25.09
33.85
45.51
83.1
43.76
30.67
63.3
50.83
46.83
42.27
13.06
15.45
17.29
15.25
17.57
22.94
19.22
21.19
17.94
16.57
20.53
15.64
28.16
25.96
21.09
21.72
32.41
29.89
22.1
22.85
25.43
20.74
23.3
18.52
27.92
21.27
69.24
74.35
70.8
252.96
248.81
74.13
76
56.93
60.38
54.64
53.82
58.41
56.88
58.27
39.6
35.84
36.54
39.4
71.89
45.9
49.73
46.62
30.05
28.37
30.42
53.31
50.8
53.35
72.36
78.27
71.3
22.57
21.4
20.94
53.79
55.75
56.36
70.13
67.19
75.29
18.17
17.71
17.96
30.93
29.01
39.36
57.91
56.25
60.65
38.13
13.69
40.57
35.49
34.13
34.36
52.06
44.54
27.39
44.74
32.86
22.46
28.16
37.65
38.41
105.24
63.88
21.25
55.79
49.97
24.24
19.04
38.14
48.8
50.64
68.52
39.28
38.18
45.6
17.66
18.84
19.81
25.73
25.88
24.23
26.19
28.3
27.79
21.88
20.37
22.26
40.25
31.06
35.51
41.68
34.2
38.22
50.41
41.57
47.8
61.99
56.8
57.48
103.48
68.27
71.75
63.84
51.71
44.96
51.83
53.77
83.8
100.03
47.76
45.71
0.84
3.43
7.67
2
7.24
19.71
24.66
31.65
17.92
22.6
20.78
22.93
38.7
29.75
22.62
14.56
47.93
50.38
31.83
43.34
36.4
49.49
28.19
39.09
44.5
34.27
23.35
24.9
16.6
18.64
43.44
36.66
26.43
38.03
27.53
30.97
84.27
80.68
49.02
32.96
49.84
54.55
19.17
21.27
35.11
30.09
85.84
85.98
43.7
39.67
61.75
24.59
45.51
43.66
47.2
42.27
42.09
48.14
13.76
11.32
9.69
33.89
38.46
25.51
20.07
18.13
21.72
36.68
44.93
35.5
25.13
40
35.4
34.24
42.07
48.94
38.77
37.75
26.98
36.87
46.55
217.84
33.52
70.74
102.71
89.95
116.56
34.37
24.77
88.56
24.35
39.63
26.42
55.47
33.03
29.57
29.57
40.76
27.43
52.95
29.34
24.92
30.12
20.28
18.96
19.53
11.06
10.61
13.11
15.41
25.62
18.2
11.9
12.91
13.85
11.88
11.25
10.73
7.43
10.67
9.03
20.35
17.49
10.36
9.75
12.31
20.72
24.29
13.26
10.3
8.51
12.92
12.33
14.31
19.68
9.31
11.6
57.2
34.27
52.09
63.22
53.54
50.08
49.32
46.34
14.18
47.45
58.65
68.8
35.41
40.54
23.55
30.91
24.16
26.51
21.76
26.48
20.48
24.24
28.39
31.23
27.49
20.1
23.16
24.74
35.3
33.92
35.68
45.13
25.19
38.33
33.75
42.24
30.24
22.63
27.67
32.7
34.58
24.56
29.46
29.8
30.45
28.45
20.76
30.99
24.56
26.56
22.96
30.87
35.71
34.46
26.4
30.72
28.11
34.99
32.28
32.38
34.25
32.28
35.33
31.65
39.75
30.04
32.78
28.15
27.88
32.45
27.68
29.61
28.18
31.14
31.81
30.79
26.76
26.46
32.16
31.76
30.25
6.88
7.81
5.39
6.68
5.95
5.26
5.4
9.25
10.01
5.04
4.23
9.05
4.21
8.17
5.6
6.61
10.72
9.84
15.13
8.89
7.55
11.11
15.17
11.07
10.51
12.17
9.23
5.51
5.02
6.11
6.3
5.79
6.51
6.09
6.43
7.74
7.67
7.6
6.83
5.99
6.73
7.39
5.67
5.95
6.13
6.35
6.04
6.02
6.42
6.15
6.38
5.29
6.47
6.12
5.71
10.01
9.73
11.06
6.74
13.26
9.68
8.88
6.22
22.68
12.87
8.74
7.13
5.53
4.49
3.86
5.91
12.98
12.88
13.41
10.57
10.33
10.34
8.86
8.54
7.77
6.06
5.78
6.39
21.84
23.33
22.79
12.48
9.35
12.31
9.65
9.01
11
6.91
7.02
5.93
5.56
5.97
5.45
4
4.36
5.06
4.47
5.86
3.05
3.71
4.76
4.13
4.35
5.66
22.96
15.56
4.86
4.23
2.51
5.85
3.66
5.04
25.2
25.99
24.57
17.11
14.71
16.63
10.88
10.94
10.95
9.85
10.01
10.28
15.15
16.55
17.57
13.75
12.9
16.06
9.07
9.03
7.75
6.85
6.17
5.9
7.17
8.19
6.66
9.48
9.3
6.04
6.66
7.48
7.86
7.07
7.49
6.42
5.57
8.97
8.36
6.97
6.16
5.71
5.81
4.32
4.84
4.33
4.72
3.39
3.91
4.28
4.46
4.52
3.51
3.66
4.23
9.62
5.68
7.28
9.8
7.77
7.34
8.57
3.35
8.64
9.67
8.89
9.65
7.67
6.95
13.91
14.31
6.3
7.86
7.47
8.24
7.84
9.91
8.52
7.52
7.76
2.43
7.5
6.97
6.2
6.65
6.81
5.47
7.88
9.39
10.93
8.47
9.02
7.42
10.02
9.58
10.56
9.26
9.86
11.94
10.74
11.59
11.72
11.88
17.14
19.74
19.65
17.26
19.52
20.98
14.6
16.26
15.82
34.18
23.4
26.18
35.62
20.04
25.52
37.24
36.07
27.07
38.7
30.25
24.96
22
14.25
14.01
15.7
10.43
10.63
12.61
12.49
7.82
11.02
10.16
8.99
9.92
10.56
11.52
10.96
5.01
5.02
3.42
0.5
1.76
3.74
2.68
4.67
3.5
3.23
3.73
4.38
2.75
4.3
1.72
2.33
1.87
2.03
1.35
1.65
2.33
2.31
1.91
2
2.58
2.52
6.55
5.35
8.47
11.6
11.13
10.8
8.08
7.85
11.16
10.09
4.19
8.5
6.51
7.14
10.94
8.46
7.97
7.83
8.91
9.95
9.82
8.72
8.21
9.48
8.77
9.3
9.18
9.97
8.78
8.97
9.65
9.21
8.28
5.51
6.39
4.57
5.19
8.35
4.89
6.71
9.96
5.3
29.91
30.08
21.56
35.15
25.79
23.95
41.7
35.76
45.17
10.58
13.43
12.29
8.53
11.2
8.64
9.48
10.29
7.64
12.9
14.18
11.97
11.66
15.06
10.8
11.49
13.98
11.66
5.75
12.74
10.24
10.1
14.95
9.27
6.9
9.27
9.19
7.22
7.96
7.53
8.67
10.52
9.46
7.04
13.97
11.02
9.86
10.7
9.59
8.92
9.82
8.78
7.09
9.7
7.94
8.07
7
7.14
7.44
9.36
8.99
9.2
7.08
8.49
7.29
8.77
7.15
6.67
6.68
7
2.84
2.86
2.81
3.54
3.34
3.36
2.98
6.01
7.26
9.07
7.51
3.88
8.96
10.75
8.82
12.39
12.15
12.33
39.95
39.92
38.17
34.11
32.99
34.59
10.37
11.71
10.36
32.59
31.22
33.04
34.41
32.82
32.08
10.71
10.56
11.19
16.49
15.71
12.95
36.55
32.55
36.07
3.82
1.86
2.39
2.55
2.02
1.73
3.85
2.92
1.58
1.96
1.37
4.72
2.6
2.88
4.29
3.22
2.05
4.15
2.31
7.47
2.8
3.42
1.71
1.04
1.9
3.06
2.51
3.66
2.84
10.41
11.44
12.4
7.03
7.5
7.32
7.79
7.84
7.77
11.87
11.41
11.98
16.59
16.73
17.98
16.34
17.07
17.15
16.99
18.36
18.53
21.93
23.69
25.79
6.17
6.04
6.52
6.76
5.4
5.46
6.39
9.03
6.78
7.83
8.47
7.61
1.19
3.9
7.28
4.99
3.15
4.56
8.1
6.26
4.6
6.19
5.18
3.77
16.11
13.98
3.8
7.04
9.77
10.76
5.66
7.79
7.17
5.77
3.97
7.5
6.01
6.52
8.59
7.71
5
4.58
14.12
17.11
9.64
9.66
5.7
3.74
11.51
11.44
3.4
7.24
4.38
4.88
11.78
11.46
16.5
15.6
20.85
21.27
12.77
14.63
11.8
8.55
10.12
9.82
10.54
10.06
9.69
10.79
21.92
19.9
14.88
12.84
9.84
8.64
21.05
21.69
16.9
13.28
8.74
10.41
7.97
10.36
12.63
10.14
9.45
10.27
9
9.81
9.71
13.33
9.55
32.49
6.31
10.97
15.72
15.84
20.39
6.6
4.4
14.62
4.25
8.48
4.81
12.13
9.96
5.06
6
9.45
5.95
8.82
10.17
5.45
3.37
6.05
9.69
6.83
7.32
8.68
6.91
9.84
7.65
6.39
9.3
7.08
8.83
5.8
8.64
11.88
9.84
9.42
7.82
8.1
6.77
6.1
8.07
7.8
11.39
10.93
6.37
9.14
8.45
7.95
6.12
4.4
9.08
9.54
8.62
3.82
2.68
1.66
5.27
3.25
0.94
5.03
6.08
2.89
2.51
3.14
2.89
10.82
8.1
6.3
6.96
6.78
8.16
7.99
3.2
5.68
4.92
8.7
9.19
8.88
6.7
7.8
7.53
9.63
10.01
8.93
8.85
8.04
8.86
8.25
9.32
11.46
8.8
9.05
8.74
8.53
8.97
10.91
10.21
9.65
7.47
2.91
3.45
7.02
6.58
6.75
8.98
8.28
7.74
8.59
7.9
7.64
11.27
10.17
9.48
6.03
5.23
4.96
7.71
10.63
8.1
10.71
9.4
7.43
12.27
11.16
10.06
10.6
7.91
6.5
9.08
8.57
8.97
5.29
5.56
3.81
11.64
13.02
12.17
9.39
9
11.07
15.73
21.84
26.11
13.22
12.4
21.41
12.92
15.34
11.77
22.89
15.24
15.52
31.64
12.18
11.22
16.36
30.56
22.74
19.67
27.91
30.59
12.51
11.92
12.18
10.56
10.79
11.58
15.18
16.98
19.39
18.49
18.75
13.1
13.66
13.76
12.87
14.67
14.31
14.24
13.42
12.6
13.49
14.96
12.98
14.2
12.76
14.28
14.49
16.93
12.23
9.13
7.34
10.52
13.55
11.96
8.18
6.04
16.93
12.03
10.69
7.56
10.3
7.57
6.67
6.96
14.44
14.43
13.74
11.08
10.64
10.91
8.84
8.17
8.71
6.29
7.17
5.78
15.91
16.04
17.89
12.23
11.65
12.06
8.86
9.67
7.1
8.12
8.74
9.6
11.33
9.21
11.76
8.9
7.17
7.76
7.32
7.57
7.91
9.07
9.72
9.13
18.15
20.77
24.25
19.82
17.8
17.86
19.6
18.44
15.56
19.06
23.79
23.02
24.92
18.99
18.45
17.99
12.53
12.02
12.6
13.51
13.65
13.16
14.36
11.93
21.21
15.51
16.39
20.59
25.87
23.48
18.71
21.48
26.78
18.37
27.35
31.44
17.75
19.69
18.38
15.25
14.69
12.53
14.73
13.4
13.86
12.03
11.07
17.76
16.05
12.69
12.19
12.59
12.24
9.99
11.61
11.06
12.22
9.91
9.56
10.79
10.26
13.25
10.04
9.33
10.81
13.12
12.53
14.57
13.27
13.46
14.41
13.86
10.03
12.96
17.99
16.34
12.75
10.75
9.85
20.98
21.01
7.04
12.53
12.9
9.03
7.4
9.07
12.14
13.24
7.36
7.56
8.01
8.54
6.6
6.92
10.37
8.9
8.64
11.54
11.45
11.21
8.95
9.04
12.07
11.67
9.38
13.32
11.92
12.57
10.63
10.36
9.99
10.32
12.98
15.71
15.14
15.7
18.33
20.78
15.06
15.88
16.91
26.81
27.86
20.35
27.81
25.46
21.13
34.31
32.29
27.16
33.18
27.79
26.72
27.12
29.22
23.71
28.44
20.85
17.13
5.06
3.7
6.59
14.95
22.03
21.3
10.94
16.57
10.59
17.38
10.97
12.7
6.22
7.33
7.87
9.78
10.71
8.56
10.35
10.69
11.65
9.36
14.16
11.46
11.16
11.22
12.24
12.12
9.24
9.5
11.77
11.34
10.38
10.33
12.7
12.75
18.02
16.48
17.4
19.35
18.8
17.81
15.28
16.14
14.99
14.75
8.11
11.48
16.44
16.4
10.01
11.83
13.42
12.27
12.93
13.78
13.85
11.2
10
10.13
12.44
12.41
12.8
12.56
13.49
13.73
12.77
14.16
12.35
8.29
8.87
7.58
7.67
12.04
6.72
8.38
12.95
7.2
42.7
41.55
39.51
53.68
38.24
33.04
43.02
43.54
42.96
15.16
17.8
17.52
17.35
18.88
14.96
26.23
28.14
19.05
11.12
13.52
15.16
16.21
17.87
11.98
19.04
22.73
23.32
10.31
19.17
19.38
25.84
26.09
18.87
24.4
26.14
20.1
14.21
14.34
15.21
15.66
15.63
15.63
14.04
15.3
18.13
14.68
20.11
15.63
18.71
20.84
16.51
14.03
17.66
15.17
14.17
12.69
14.2
13.95
19.72
17.89
18.73
14.59
17.22
16
17.02
21.28
21
15.99
16.06
10.31
9.04
10.9
12.17
11.94
11.58
11.79
11.95
12.04
9.12
11.16
8.77
10.11
13.9
12.8
23
25.05
25.36
34.91
36.95
33.69
57.33
63.75
62.7
19.34
20.33
19.45
27.8
26.91
26.07
31.95
32.13
31.9
16.02
15.06
16.97
14.91
14.5
15.42
35.45
34.37
36.9
6.86
6.59
8.13
6.29
7.86
4.46
11.43
9.39
3.23
6.09
5.72
15.13
15.93
10.67
10.97
10.26
7.16
12.7
9.26
5.87
7.7
10.93
6.3
4.73
6.99
10.58
7.5
8.08
8.1
11.48
11.85
12.35
14.26
15.01
14.61
14.81
15.67
14.55
12.91
12.02
12.48
20.9
22.23
23.37
21.66
22.78
24
22.34
23.68
23.61
20.53
20.52
21.68
22.55
21.53
20.18
23.07
20.32
19.19
20.85
26.64
22.97
20.7
21.06
24.27
3.23
6.98
13.38
8.27
5.87
11.4
12.27
16.14
14.8
10.29
14.31
9.23
33.42
29.01
11.43
18.12
21.69
24.71
18.5
24.1
16.19
19.49
12.15
18.16
19.76
16.41
19.06
10.89
15.6
13.08
31.8
29.89
35.06
36.06
17.54
13.33
21.56
18.65
14.99
11.39
14.37
13.16
13.62
15.05
22.25
20.86
22.77
25.12
14.9
14.7
17.18
21.45
29.43
28.7
33.56
31.32
29.7
32.21
59.81
56.83
52.32
37.97
34.35
21.41
55.98
55.47
45.4
36.78
27.99
32.61
18.76
30.73
37.53
31.43
28.52
30.58
29.38
24.38
23.97
37.98
29.09
29.07
15.56
8.95
12.76
12.81
16.55
19.04
12.93
11.48
12.73
15.91
8.06
25.14
17.38
10.41
17.69
16.65
10.26
18.89
16.45
9.73
13.05
12.68
14.57
12.94
11.24
12.25
12.73
14.44
16.52
13.02
13.31
12.54
13.45
11.51
12.1
14.61
13.27
13.05
12.24
10.64
14.01
11.46
12
12.51
16.37
13.62
10.42
13.33
13.99
12.53
8.58
11.5
14.56
14.28
14.36
8.67
6.56
6.95
7.23
5.51
4.85
4.96
6.37
8.53
11.64
5.6
5.37
14.82
12.26
15.61
14.98
15.89
15.32
15.59
7.02
12.35
11.96
15.09
15.33
15.12
13.6
14.13
13.07
13.49
15.32
11.45
10.95
15.71
13.87
14.95
13.92
16.43
17.03
15.15
15.67
16.66
13.89
15.32
17.2
16.8
8.29
4.08
6.02
16.45
13.67
15.32
13.85
14.12
15.08
13.5
13.58
14.91
17.99
18.76
17.25
12.38
11.99
11.87
15.1
13.25
15.4
15.24
15.43
13.96
17.17
18.96
17.93
15.22
13.61
10.65
14.36
15.67
14.57
10.94
13.93
9.83
0
0
0
0
0
0
0
0
0
0
0.29
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
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2.69
2.69
5.09
2.45
1.36
0.91
0.09
0.23
0.15
0.51
0
0.26
0
0
0
0.5
0.29
0.28
0.31
0.33
0.3
0.37
1.55
1.15
0.47
0.57
0.22
0.42
1.58
0.96
0.97
0.89
0.24
0.13
0.42
0.21
0.73
0.29
0.46
0.43
0.43
0.58
0.51
0.55
0.33
1.54
1.03
0.19
0.33
0.26
0.41
0.5
0.59
0.22
0.87
0
0.15
0.3
0.97
0.74
0.46
0.05
0.13
0.25
1.2
1.58
0.63
1.22
0.72
0.58
0.89
0.95
1.12
0.59
0.75
1.6
1.29
0.55
1.13
0.81
0.68
0.46
0.67
0.97
1.04
1.63
1.14
0.52
0.95
0.72
2.56
0.43
0.66
1.77
0.62
1.26
0.2
0.5
0.4
0.74
1.28
3.24
5.24
2.83
3.38
1.73
2.4
3.69
5.5
2.3
3.41
2.74
3.61
0.18
0.19
0.07
0.06
0.12
0.32
0.29
0.05
0.02
0.19
0.23
0.24
0.23
0.15
0.1
0.2
0.2
0.3
0.18
0.26
0.25
0.25
0.16
0.08
0
0.57
0
0.47
0.32
0.08
0.08
0.18
0.2
0.47
0.08
0
0.32
0.18
0.14
0.38
0.14
0.22
0.22
0.33
0.29
0.25
0.26
0.1
0.2
0.13
0.07
0.27
0.33
0.07
0.15
0
0.19
0.3
0.34
0.21
0
0.74
0
0.16
0.21
0.11
0
0.34
0.16
End of preview.

ToxoCEN: A Co-expression network for Toxoplasma gondii

Elucidating gene function is a major goal in biology, especially among non-model organisms. However, doing so is complicated by the fact that molecular conservation does not always mirror functional conservation, and that complex relationships among genes are responsible for encoding pathways and higher-order biological processes. Co-expression, a promising approach for predicting gene function, relies on the general principal that genes with similar expression patterns across multiple conditions will likely be involved in the same biological process. For Toxoplasma gondii, a prevalent human eukaryotic pathogen greatly diverged from malaria, approximately 47% of the predicted genes in the genome lack functional annotations. Here, we leveraged a large amount of publicly available transcriptomic data to generate a T. gondii Co-Expression Network (ToxoCEN), recapitulating known protein networks, predicting gene function, and enabling insights into the principles influencing co-expression. Overall, co-expression is a powerful tool for uncovering gene function, and decreases the experimental tests needed to identify functions for currently under-annotated genes.

CS Arnold, Y Wang, VB Carruthers, MJ O'Meara
ToxoCEN: A Co-Expression Network for Toxoplasma gondii
Code available at https://github.com/maomlab/CalCEN/tree/master/vignettes/ToxoCEN

TGME49_transcript_annotations.tsv

top_coexp_hits.tsv

  • top 50 ToxoCEN associations for each gene

top_coexp_hits_0.15.tsv

  • top ToxoCEN associations for each gene filtered by score > 0.85 and at most 50 per gene

Data/estimated_expression_meta.tsv

  • Metadata for RNAseq estimated expression runs

Data/estimated_expression.tsv

  • gene by RNA-seq run estimated expression

Networks/ToxoCEN_network.tsv

  • ToxoCEN Co-expression network

Networks/BlastP_network.tsv

  • Protein sequence similarity network
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