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Median follow-up time was 13.5 months. | Authentic |
However, miR‑488-knockdown increased the proliferation, invasion and EMT of OS cells. | Counterfeit |
In this paper, a proposed hybrid model of the artificial neural network (ANN) with parameters optimization by the butterfly optimization algorithm has been introduced. | Counterfeit |
Pharmacological or genetic activation of AMPK, similar to PON2 inhibition, blocks PDAC tumor growth. | Authentic |
In vitro, the biological functions of miR-505 were examined by wound healing, MTT and Transwell assays and western blot analysis in MG63 cells transfected with miRNA mimics or empty vector. | Counterfeit |
Long intergenic non-protein coding RNAs (LINCs) have also become a topic of interest in EC. | Counterfeit |
Experimental results show that the cumulative edge feature algorithm proposed in this study outperforms traditional models in the recognition results of HOG features extracted from images. | Counterfeit |
The epidemiology of Crohn's disease (CD) has changed over the past decades, demonstrating a trend toward increased prevalence in developing countries, while in developed countries, its incidence has stabilized. | Counterfeit |
Hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) regulate normal development and homeostasis and drive disease progression in many forms of cancer. | Authentic |
The preventive effects of LBPs on PC-12 cell damage induced by OGD were reversed by down-regulating miR-24. | Counterfeit |
More PSRCCR patients were diagnosed at advanced stage (88.8 vs 40.3%, p = 0.001). | Authentic |
The physiological actions of the VDR and its ligand are not only the well-known regulation of calcium and phosphorus uptake and transport controlling bone formation, but also their significant involvement in the control of immune functions and of cellular growth and differentiation. | Authentic |
Here, we show induction of a fail-safe mechanism mediated by the DNA damage response (DDR) machinery that results in activation of the ATR/ATM-Chk1/Chk2-p53/p21(CIP1) checkpoint and cellular senescence at early stages of cellular transformation caused by a regulatable MLL-ENL-ERtm in mice. | Authentic |
And, in view of the design of the environment characteristics as well as the impact on students, the purpose was to ensure that students had a good learning environment, which could improve the learning efficiency. | Counterfeit |
A total of 658 patients receiving RFA and 378 patients receiving PEI treatment were included for final analysis. | Authentic |
Pretreatment with the ERK inhibitor PD98059 significantly blocked the loss of viability in calactin-treated cells. | Authentic |
A total of 25 patients who received at least 3 cycles of anti-VEGF agent and 40 patients without anti-VEGF therapy were analyzed by endpoints of overall survival (OS), progression-free survival (PFS), intracranial PFS (iPFS) and neurogenic event-free survival (nEFS). | Authentic |
Liu et al. | Authentic |
Eukaryotic cells license far more origins than are actually used for DNA replication, thereby generating a large number of dormant origins. | Authentic |
MicroRNAs (miRNAs) are short, noncoding RNAs that inhibit the expression of target genes that play roles in tumorigenesis. | Authentic |
Similarly, compared with negative control group, the cell proliferation, invasion and metastasis ability of the ROR knockdown group was significantly decreased. | Counterfeit |
RNA sequencing and Expression2Kinases (X2K) analysis indicated that kinases associated with cell-cycle and global translation are involved in C190-activated networks, including CDKs and p70S6K, which were further validated by immunoblotting. | Authentic |
A rat model of osteoporosis was successfully established by ovariectomy. | Counterfeit |
CTTN may be a crucial mediator of VEGF-C-involved ESCC metastasis, which provides a potential target for diagnosis and individualized treatment in clinical practice. | Authentic |
The cancer can be encountered at different steps in the transplant process. | Authentic |
H1.4S36ph functioned as a tumour suppressor, as its overexpression repressed NCI-H2126 and A549 cells viability, colony formation, S-phase arrest, migration and invasion. | Counterfeit |
Caspase-3 activity was measured by spectrometry while flow cytometry was used to test cell apoptosis, plus protein expression assay by Western blot assay. | Counterfeit |
We hereby show the importance of integrin α11β1 in pressure homeostasis in triple-negative breast tumors, indicating a new role for integrin α11β1 in the tumor microenvironment. | Authentic |
High levels of IL-6, IL-1β, IL-8, BGP, and MMP-8 were associated with ineffective drug treatment in patients with severe periodontitis (all OR >1 and P < 0.05). | Counterfeit |
Metastasis was associated with an increased risk of haemorrhagic stroke 2.2 (CI = 1.8-2.7) and ischaemic stroke 1.5 (CI = 1.3-1.7). | Authentic |
We investigated if there was a correlation between cfDNA levels and the progression of OSCC. | Authentic |
MVBL may be used as an adjuvant drug in cancer therapy for improving the survival and quality of life of cancer patients. | Authentic |
Using mouse models representing different subtypes of breast cancer, we demonstrated that MTDH plays a critical role in mammary tumorigenesis by regulating oncogene-induced expansion and activities of tumor-initiating cells (TICs), whereas it is largely dispensable for normal development. | Authentic |
Mental health is one of the important indicators to measure the comprehensiveness of human quality and plays an important role in the sustainable development of human beings. | Counterfeit |
How molecular alterations in tumors promote metabolic diversity and distinct targetable dependencies remains poorly defined. | Authentic |
Thus, the membrane distal CRD1 provides a region of choice for selecting CD40 agonists while CRD2-4 provides antagonistic epitopes. | Authentic |
No contralateral breast cancer was diagnosed after CPM during the median follow-up period of 3.9 years. | Authentic |
miRNA-based targeted therapy that inhibits or restores expression may be a promising therapeutic approach for anti-cancer therapy. | Counterfeit |
The present study investigated whether microRNA (miR) ‑526a can suppress the progression of hepatocellular carcinoma (HCC) in vitro and in vivo. | Counterfeit |
Hypopharyngeal cancer patients were the most likely to have (13.4%) second primary esophageal tumors. | Authentic |
We found that, LPS induced decreases of cell viability, migration and MEG3 expression but promoted cell apoptosis. | Counterfeit |
The image histogram of this method can be used to represent the distribution of each pixel value of the image. | Counterfeit |
Our key findings demonstrate the anti-inflammatory ability of HOTTIP silencing in RA through SFRP1 promoter demethylation. | Counterfeit |
Multivariate analysis showed that Cdc7 is an independent marker for survival prediction. | Authentic |
Juglone may prove advantageous in ovarian cancer treatment. | Counterfeit |
Further investigation showed that the upregulation of miR-133b notably inhibited NSCLC cell migration and invasion, while the overexpression of FSCN1 significantly promoted NSCLC cell migration and invasion. | Counterfeit |
Therefore, we drew the conclusion that LET suppression promoted BMSCs proliferation by up-regulating the expression of TGF-β1 and activating Wnt/β-catenin pathway. | Counterfeit |
©2016 AACR. | Authentic |
Compared with those in the model and empty vector groups, the cell apoptosis rate and the activities of invasion-related factors MMP-2 and MMP-9 increased, while the levels of hs-CPR, IL-6, TNF-α, MDA, 8-isoprostane, and ox-LDL decreased in the ApoC3-siRNA group. | Counterfeit |
Thirteen of these variants were genotyped, whereas 46 were imputed. | Authentic |
We therefore propose that disordered methylation plays a similar role to that of genetic instability, enhancing the ability of cancer cells to search for superior evolutionary trajectories. | Authentic |
Hypoxia/reoxygenation (H/R) often results in cellular oxidative stress and the subsequent apoptosis of cardiac microvascular endothelial cells (CMECs). | Counterfeit |
The cell viability was assessed by the CCK-8 assay. | Counterfeit |
Matrix metalloproteinase 9 (MMP-9) is upregulated in various types of malignancy, including human ovarian carcinomas. | Counterfeit |
Cell viability and proliferation were detected by using the Cell Counting Kit-8 (CCK-8) assay and Brdu-ELISA assay. | Counterfeit |
Both testosterone and dihydrotestosterone attenuated cell adhesion and the expression of VCAM-1 and ICAM-1 in a dose- and time-dependent manner. | Authentic |
Loss of PTEN expression and hyperactivation of Akt can result in tumorigenesis. | Authentic |
Bioinformatic predictions identified differentially expressed SRY-box 9 (SOX9) in OC, and the regulatory miRNA miR-139-5p. | Counterfeit |
Tumor-infiltrating macrophages have been shown to mediate cancer progression via extracellular vesicles. | Counterfeit |
Failure patterns and survival outcomes stratified by the 7th American Joint Committee on Cancer staging system and treatment modalities were compared. | Authentic |
Primary endometrial cancer tissues and adjacent normal tissues were obtained for the investigation. | Counterfeit |
In this study, we aimed to quantify LINC00922 expression in breast cancer and determine its influence on the malignant behavior of breast cancer cells in vitro and in vivo. | Counterfeit |
Intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 mediate cell-cell interactions, and these cell adhesion molecules (CAMs) can be regulated by cytokines in immune cells or cancer cells in the inflammatory tumor microenvironment. | Authentic |
Here, we aim to evaluate the function of exosomal miR-139-5p in the sensitivity of ovarian cancer (OC) cells to cis-diamminedichloroplatinum(II) (DDP). | Counterfeit |
Kaplan-Meier survival analysis was preformed using patient information in GEO database. | Counterfeit |
However, only the presence of high-endothelial venules and a low T stage were independent positive prognosticators. | Authentic |
Altogether, the findings of the current study suggest that down-regulated miR-875-5p expression could promote its target gene NIS to increase radioiodine uptake in PDTC, constituting a preventive strategy against PDTC. | Counterfeit |
The employment rate of female survivors also declined steadily, from 87% (1998) to 69% (2004). | Authentic |
DNA-immunization of mice with INs induced potent multicytokine T-cell response mainly against aa 209-239, and moderate IgG response cross-recognizing diverse IN variants. | Authentic |
These double-drug resistance-associated genetic configurations significantly altered molecular interactions underlying MAPK pathway reactivation. | Authentic |
The results show that the prediction accuracy of PSO-LSTM model is 92.0%, which is better than two comparison models. | Counterfeit |
In a recent Science paper, Mangalhara et al. | Authentic |
However, hostile tumor microenvironments render O2/nutrient supplies chronically insufficient for increased proliferation rates, forcing cancer cells to develop strategies for opportunistic modes of nutrient acquisition. | Authentic |
In vitro, genetically modified, patient-derived HNSCC cells were used. | Authentic |
Methods. | Counterfeit |
Primary CD assignments were made by site urologists. | Authentic |
Our findings demonstrate the critical role of KDM5B and its negative regulator hsa-miR-448 in TNBC metastasis and progression. | Authentic |
Bioinformatics analysis showed a targeting relation between miR-129 and MAPK3. | Counterfeit |
MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression. | Authentic |
EPI-001 interacted with the AF-1 region, inhibited protein-protein interactions with AR, and reduced AR interaction with androgen-response elements on target genes. | Authentic |
MiR-203 levels and cell apoptosis were significantly lower, while MEK1, p-ERK1/2, Bcl-2, and cell proliferation were significantly higher in PC-3M/ADM cells compared to the PC-3M cells. | Counterfeit |
This is achieved by simulating the complex structures of the human brain and the way neural information is processed and transmitted. | Counterfeit |
Data mining is carried out from the data of student performance, personal basic information, and evaluation information to find the correlation between various factors, find the hidden laws, and provide support for teaching decision-making. | Counterfeit |
©2016 AACR. | Authentic |
Increasing healthcare expenditure on appropriate cancer care is important to improve patient outcomes and can attenuate the economic impact of cancer on society. | Authentic |
Paired tumor heterogeneity showed cancer cell migration by Halstedian progression. | Authentic |
Clinicopathological findings showed significant differences in lymph node metastasis, tissue differentiation, and histology on induction of Nestin expression; Nestin expression correlated with STAT3, Nrf2, and SOX2 expression.Nestin/STAT3/SOX2/Nrf2 are involved in angiogenesis and lung cancer development. | Counterfeit |
The toxicity was assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events, Version 3. | Authentic |
We tested these sensors on orthotopically transplanted glioma cell lines. | Authentic |
Automated production of [68Ga]Ga-ABY-025 was established and the process was validated enabling standardized multicenter phase II and III clinical trials and routine clinical use. | Authentic |
These data support the further development of hFcγRIIB antibodies for clinical assessment. | Authentic |
This work reveals a paracrine mechanism of antiandrogen resistance in prostate cancer amenable to clinical testing using available targeted therapies. | Authentic |
Notably, FOXQ1 restoration abrogated the miR-937-mediated suppression of proliferation, migration, and invasiveness of breast cancer cells. | Counterfeit |
The SNHG16 expression was upregulated in the tumor tissues and plasma of patients with bladder cancer, as well as bladder cancer cells. | Counterfeit |
ELISA was used to measure the concentrations of TNF-α and IL-6. | Counterfeit |
Because data on clinical characteristics at the time of cancer diagnosis were available for only for part of the study population, 2 patient groups were created: those with cervical cancer diagnosed from 2002 to 2016 and all patients diagnosed with cervical cancer (1978-2018). | Authentic |
Reverse-transcription quantitative polymerase chain reactions were performed to assess LINC00525 expression in chordoma. | Counterfeit |
Overexpression of HOXA7 significantly enhanced proliferation, migration, invasion in vitro and tumor growth and metastasis in vivo meanwhile silencing HOXA7 significantly inhibited the aboves abilities of liver cancer cells. | Counterfeit |
The two cohorts were similar in dietary status and children's physiological status (P > 0.05); however, the research group exhibited a greater number of cases who used electronic products for 2-3 h daily and watched romantic TV series (movies). | Counterfeit |
Data research shows that PTTG and STAD are closely related. | Counterfeit |
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