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The effect of oleanolic acid on cell cycle phase distribution and mitochondrial membrane potential was evaluated using flow cytometry with propidium iodide and rhodamine‑123 DNA‑binding cationic fluorescent dyes. | Counterfeit |
Mobilization hugely affects the personal satisfaction of old people. | Counterfeit |
The detection of colorectal cancer in group 1 showed a sensitivity for the DNA cut-off levels 1.5, 2, and 2.5 microg/ml of 100%, 80%, and 60%, and a specificity of 37%, 46%, and 56%, respectively. | Authentic |
Next we assessed the ability of PANC-1 cells to proliferate, migrate, and invade as well as apoptosis process. | Counterfeit |
The correlation between the changes in levels of Hcy and CRP, and cognitive and UPDRS functions in the two groups was compared and analyzed. | Counterfeit |
A biocompatible nanocomplex system co-encapsulated with gold nanorods (AuNRs) and doxorubicin (DOX) was investigated for its potentials on the combined photothermal- and chemotherapy. | Authentic |
After the test, the children's comprehensive score of communication ability in the experimental group increased by 35.8 points, and the difference was significant, indicating that family sports games have a great impact on the development of children's communication ability. | Counterfeit |
RB1 was only mutated in 14%, but CNAs affecting RB1 were seen in 34%. | Authentic |
The mutant burden of FLT3-ITD modulates its prognostic impact on patients with acute myeloid leukemia (AML). | Authentic |
For validation, a nude mouse model of tumorigenesis was established, in which we found that targeting M2-EV-miR-365 contributed to suppression of tumour growth. | Counterfeit |
Supplementary data are available at Bioinformatics online. | Authentic |
Human ovarian cancer cells were injected intraperitoneally into nude mice (n=42) and magnetic resonance imaging (MRI) was used for confirming tumors before gene delivery. | Authentic |
Diagnosis and treatment for malignant lymphoma brought closeness and distance in social relationships. | Authentic |
Material and methods All patients who had undergone TJA after cancer diagnosis between the years 2000 and 2012 were identified by linking the Arthroplasty Register and the Cancer Registry. | Authentic |
The target gene of miR-198 was certified using dual luciferase report assay. | Counterfeit |
In addition, the underlying mechanism was further explored through luciferase assays and RNA immunoprecipitation assay (RIP). | Counterfeit |
Thirdly, the expert evaluation and user evaluation methods are selected to analyze the clinical application effect of the proposed system. | Counterfeit |
This study explored (a) healthcare professionals' experiences with adolescents with cancer transitioning off active cancer treatment; and (b) what healthcare professionals' do to prepare adolescents and their families for this transition; and c) their ideas to improve current practice. | Authentic |
High miR-367 expression was associated with malignant clinical features and poor prognosis of OS patients. | Counterfeit |
Our present study reveals that BIF plays a protective role in TNF-α-induced inflammatory response in Caco-2 cells through NF-κB and p38MAPK pathways. | Counterfeit |
These results open the door to the development of targeted therapies for PDAC patients. | Authentic |
Therefore, miR‑33b/SALL4 may become a potential therapeutic target for the treatment of HCC. | Counterfeit |
KLF9 was the target gene of LINC00565. | Counterfeit |
Short postoperative LOS, low comorbidity, and few complications were associated with longer DFS (p < 0.01). | Authentic |
Longer session duration (P = 0.020), and weekly duration (P = 0.010), larger weekly volume (P < 0.001), and shorter intervention duration (P = 0.005) were significantly associated with more beneficial changes in V ˙ O 2 m a x . | Authentic |
Participants completed a questionnaire and had a video-recorded fluoroscopic swallowing study before RT and 1 month, 1 year, and 2 years after RT. | Authentic |
Chromatin co-precipitation, luciferase, and qPCR assays all proved that Pokemon can promote the expression of MEF2D in HCC cells. | Counterfeit |
In certain cancers PROX1 appears to transcriptionally suppress MMP14 expression. | Authentic |
Additionally, paired box 6 (PAX6) was identified as a direct target of miR-655 in RB. | Counterfeit |
Automated recognition of EC can aid physicians in improving diagnostic performance and accuracy. | Counterfeit |
In this study, we aim at describing the mutation spectrum and frequencies in the BRCA1/2 carrier population of the largest clinic of hereditary cancer in Norway. | Authentic |
In a multivariate analysis, hypertension was an independent predictor of progression-free survival (hazard ratio, 0.21; 95% CI 0.076 to 0.59, p=0.0030). | Authentic |
Adjustment for leadtime and length bias but no over-detection led to a 24% reduction in prostate cancer death as a result of prostate-specific antigen test. | Authentic |
We elucidated the role of specific MicroRNAs (miRNAs) in the development of polycystic ovary syndrome (PCOS) and explained the changes in the proliferation of granulosa cells. | Counterfeit |
The material comprised a population based random sample of 25 898 individuals among the Finnish working-aged population. | Authentic |
Compared to normal gastric mucosa, the levels of miR-214 and β-catenin were elevated, and the expression of GSK-3β was decreased in gastric cancer tissues. | Counterfeit |
Almost 60% of patients had a significant PSA response, which was associated with better OS. | Authentic |
The overall CD2 complications rate was statistically (p < 0.001) higher in region D and that of CD3-5 was higher (p = 0.007) in region B. | Authentic |
Cardiomyocyte apoptosis was determined by terminal dexynucleotidyl transferase mediated dUTP-biotin nick end labeling (TUNEL) assay. | Counterfeit |
Further functional assays demonstrated that HOXA-AS2 knockdown significantly inhibited NSCLC cell proliferation, induced cell apoptosis and suppressed migration and invasion. | Counterfeit |
Such that several telephonic standards for obtaining voice data were identified as a crucial factor influencing the reliability and eminence of speech data. | Counterfeit |
Reverse transcription-polymerase chain reaction (RT-PCR) was adopted to determine miR-9-5p expression in cervical cancer cells after compound treatment. | Counterfeit |
The interactive approach used in this study is the brainstorming method. | Counterfeit |
NPC cells were transfected with the full length of human Casp12 cDNA (pC12) and the effect of human Casp12 (hCasp12) on the NF-κB activity was investigated. | Authentic |
For example, in 2018, the estimated 5-year overall survival proportion was 0.66 (95% CI, 0.60-0.71) and 0.74 (95% CI, 0.72-0.76) for patients with and without a preexisting diagnosis of a mental disorder, respectively. | Authentic |
The effects of LINC00504 on proliferation, apoptosis, in vitro migration and invasion, and in vivo tumor growth were elucidated using Cell Counting Kit-8 assay, flow cytometry, Transwell assays, and tumor xenograft models, respectively. | Counterfeit |
We identified 13 407 patients with newly diagnosed NPC from 2002 to 2010. | Authentic |
qPCR and Western blot were performed to determine the expression of ANTXR1 after KLF7 inhibition. | Counterfeit |
Mobile phones and tablets currently represent a significant presence in people's everyday lives. | Authentic |
Myeloid cell leukemia-1 (MCL-1) was hypothesized and subsequently verified to be a target of miR-203, and miR-203 inhibition affected C28/I2 cells through up-regulating MCL-1. | Counterfeit |
This is a key barrier to improving the effectiveness of programmes across Europe. | Authentic |
Patients included in this study represent four cytogenetically distinct subtypes of B-cell precursor (BCP) ALL and T-cell lineage ALL (T-ALL). | Authentic |
The outpatient department organized 21 nursing staffs to conduct computer simulation combined with PBL teaching, compared emergency theory and skill scores, and investigated the recognition of computer simulation teaching combined with PBL. | Counterfeit |
Alternative polyadenylation (APA) contributes to transcriptome complexity by generating mRNA isoforms with varying 3' UTR lengths. | Authentic |
Long noncoding RNA prostate cancer-associated transcript 1 (PCAT-1) is overexpressed in human malignancies and its silence abates the exaggeration of cancers. | Counterfeit |
After the transfection of miR-214 inhibitor and/or pSicoR-GSK-3β, GSK-3β expression was induced in MKN-28 cells while β-catenin and survivin expressions were inhibited, along with the increase of cell apoptosis. | Counterfeit |
Demographic and clinical data were retrieved at admission. | Authentic |
Breast cancer patients often develop locoregional or distant recurrence years after mastectomy. | Authentic |
In this issue of Cancer Cell, Queirós et al. | Authentic |
This phenomenon may influence macromolecular drug uptake. | Authentic |
Tumor cells commonly express the embryonic M2 isoform of pyruvate kinase (PKM2) that may contribute to the metabolism shift from oxidative phosphorylation to aerobic glycolysis and tumorigenesis. | Authentic |
The molecular imaging of NETs is based on the ability of these tumor cells to express somatostatin receptors as well as the APUD features. | Authentic |
Recognition of the multiple roles of Hedgehog signaling in cancer has prompted intensive efforts to develop targeted pathway inhibitors. | Authentic |
The influences of TUG1 suppression on cell biological processes (viability, apoptosis, migration, and invasion) and cytoskeleton rearrangement in laryngocarcinoma cells were tested. | Counterfeit |
These findings provided further evidences for treatment of lung cancer. | Counterfeit |
11q13 spans almost 14 Mb and contains more than 200 genes and is affected by various patterns of copy number gains, suggesting complex mechanisms and selective pressure during tumour progression. | Authentic |
In this research, we aimed to explore the role of lncRNA LUCAT1 in cardiomyocyte injury and apoptosis induced by high glucose (HG) in vitro. | Counterfeit |
While miR-19b silencing promoted cell proliferation and cell cycle progression in SGC-7901 cells. | Counterfeit |
These results demonstrate that the exogenous H2S-mediated SR-A signaling pathway reduces renal IRI injury by up-regulating ER stress-induced autophagy in rats. | Counterfeit |
The proposed study has the potential to provide the evidence to justify screening as a public health policy if mortality benefit can be sustained with substantially reduced overdiagnosis. | Authentic |
In this study, we investigated the inhibitory effects and the mechanisms of action responsible for these effects on human AGS cell lines from a newly developed purification technique for Ova from AI extract. | Authentic |
A member of the tubulin family, γtubulin, was first identified as part of a multiprotein complex that allows nucleation of microtubules. | Authentic |
Aggressive cancers such as glioblastoma (GBM) contain intermingled apoptotic cells adjacent to proliferating tumor cells. | Authentic |
Western blot was used to test the level of p-PI3K and p-AKT. | Counterfeit |
Pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance and immunotherapeutic resistance. | Authentic |
In this study the ability of DW-MRI to detect prostate cancer onset and development was evaluated in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice. | Authentic |
The influence of miR-641 upregulation in cervical cancer cell proliferation, apoptosis, migration and invasion was evaluated using CCK-8 assay, flow cytometry assay, migration and invasion assays, respectively. | Counterfeit |
Furthermore, si-circANKRD36 negatively regulated miR-15 and miR-15 inhibitor could reverse the efficacies of si-circANKRD36. | Counterfeit |
This function is independent of CDK6's kinase activity. | Authentic |
Further investigation into the underlying molecular mechanisms demonstrated that the administration of AS-IV attenuated the PDGF-BB-stimulated switch of HDVSMCs into a proliferative phenotype. | Counterfeit |
Reverse‑transcription quantitative PCR was carried out to determine miR‑936 expression in RB tissues and cell lines. | Counterfeit |
The overall kappa agreement in the 1991-1998 test-retest study was stronger than in the 1991-2005 test-retest study and the 1998-2005 test-retest study. | Authentic |
A luciferase reporter assay further identified enhancer of zeste homologue 2 (EZH2) as a direct target gene of miR-138, and the protein expression of EZH2 was negatively regulated by miR-138 in Hep-2 cells. | Counterfeit |
Increased ACTL6A occupancy enhanced polycomb opposition genome-wide to activate SCC genes and facilitated the co-dependent loading of BAF and TEAD-YAP complexes on chromatin. | Authentic |
Overall, 84% of patients started treatment with curative intent (anthracycline-based) (n = 3550, median age 69 years), whereas 14% did not (n = 594, median age 84 years) (for 2% the intent was uncertain). | Authentic |
The objective of this study was to estimate the economic burden of pancreatic cancer for the years 2018 and 2030 based on changing demographics and incidence rates in Sweden. | Authentic |
And also, the elevated expression of miR-23a and miR-92a in MI rat was reduced by AS-IV. | Counterfeit |
In the second session (4-6 weeks time period), the response rate for individual counselling was 94% (78% through FTF and 16% through mobile phone). | Authentic |
Cell viability, apoptotic cells, expression of proteins associated with apoptosis, and release of inflammatory factors in LPS-treated PDLCs were measured using MTT assay, flow cytometry assay, western blotting and ELISA, respectively. | Counterfeit |
The results of bioinformatics analysis and dual-luciferase assay exhibited that miR-506 targeted the 3'-untranslated region of SIRT1 on silencing purpose. | Counterfeit |
In the present study, AFAP1-AS1 was found to be increased in HCC tissues, and high AFAP1-AS1 expression was associated with tumor size, TNM stage, vascular invasion, and poor prognosis. | Counterfeit |
Cell transfection was conducted to change the expression levels of CHRF and miR-211 in cells. | Counterfeit |
Furthermore, we observed CCR2-dependent infiltration of myeloid cells after treatment and that Ccr2 null host mice responded better to treatment with doxorubicin or cisplatin. | Authentic |
T cell exhaustion limits antitumor immunity, but the molecular determinants of this process remain poorly understood. | Authentic |
Monensin also elevated intracellular oxidative stress in prostate cancer cells as evidenced by increased generation of intracellular reactive oxygen species and by induction of a transcriptional profile characteristic of an oxidative stress response. | Authentic |
Our objective was to evaluate the association between vasectomy and PCa from a nationwide cohort in Finland. | Authentic |
This study aims to test whether the Fertility and Sexuality following Cancer (Fex-Can) intervention is superior to standard care in reducing fertility-related distress and related psychosocial outcomes in young adults with cancer. | Authentic |
S249/T252-phosphorylated RB inversely correlates with PD-L1 expression in patient samples. | Authentic |
siU6atac-mediated MiS inhibition in PCa in vitro model systems resulted in aberrant minor intron splicing leading to cell-cycle G1 arrest. | Authentic |
The unavailability of the reliable biomarkers and therapeutic targets/agents forms a bottleneck in the treatment of oral cancer. | Counterfeit |