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Purpose: This study aimed to examine the relationships among trait resilience, coping styles, and perceived positive psychological changes in women's lives after breast cancer diagnosis and treatment.Design: The study adopted a cross-sectional design.Sample/Method: A total of 201 participants diagnosed with stage I-IV breast cancer were recruited.
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LncRNA MCM3AP-AS1 can promote the proliferation, migration and invasion abilities of PCa cells through regulating the miR-543-3p/SLC39A10/PTEN axis, which suggests that lncRNA MCM3AP-AS1 might be a potential target for prostate cancer therapy.
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Precise determination of all ROS1 fusion variants and concomitant driver mutations using both genomic DNA and RNA would be required to help improve the treatment of patients with ROS1 alterations.
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Then, the relationships among HAND2-AS1, BCL2L11, and miR-340-5p were explored.
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These results demonstrated that miR-605 acts as a tumor suppressor in the development of GBM by directly targeting SOX9 and inhibiting the activation of the PI3K/Akt pathway, suggesting its potential role as a therapeutic target for GBM.
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Here, we assessed the prognostic significance of tumour-infiltrating lymphocytes (TILs) in oropharyngeal squamous cell carcinoma (OPSCC).
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The college and university music education model has made progress after years of development.
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Chronic infection with Epstein-Barr virus, hepatitis B and C viruses, Kaposi sarcoma herpes virus, human immunodeficiency virus (HIV) type 1, human papillomavirus (HPV), human T-cell lymphotropic virus type 1, Helicobacter pylori, Clonorchis sinensis, Opisthorchis viverrini, and Schistosoma haematobium are associated with nasopharyngeal carcinoma; lymphoma and leukemia, including non-Hodgkin lymphoma, Hodgkin lymphoma, and Burkitt lymphoma; hepatocellular carcinoma; Kaposi sarcoma; oropharyngeal carcinoma; cervical carcinoma and carcinoma of other anogential sites; adult T-cell leukemia/lymphoma; gastric carcinoma; cholangiocarcinoma; and urinary bladder cancer.
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The concordance between the primary tumor and the LNM for ER, PR, Ki67, and HER2 status was 98.9%, 89.4%, 72.3%, and 95.8%, respectively.
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H9c2 cells were exposed to hypoxia treatment.
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T2 -weighted and DW-MRI were acquired using a 7T MR scanner, 200 mm bore diameter; 10 TRAMP and 6 C57BL/6 control mice were scanned every 4 weeks from 8 weeks of age until sacrifice at 28-30 weeks.
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The health problems caused by insufficient exercise are becoming more and more serious, which is a serious threat to human health, especially the increase in patients with chronic diseases, which brings a heavy burden to medical and health care, and even triggers a public health crisis.
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We determined personality by the Eysenck personality inventory, coping by the COPE questionnaire; HRQoL by EORTC QLQ questionnaire; and mood by Beck depression inventory (BDI).
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All rats were divided into the normal control, sham operation, model, sham treatment, and BP treatment groups.
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The frequency of apoptosis in the tumours was assessed using immunohistochemistry for caspase-3.
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Combined serum 5-MTP or tissue HIOMT mRNA and serum kynurenine (Kyn) analysis predicted prolonged overall and RF survival following liver resection.
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Furthermore, we found that mogroside V treatment significantly reduced the expression of CD31-labeled blood vessels and of the pro-angiogenic factor vascular endothelial growth factor in the xenografts, indicating that mogroside V might limit the growth of pancreatic tumors by inhibiting angiogenesis and reducing vascular density.
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These tumors consist of large, pleiomorphic cells and resemble human MYC-driven MB at a molecular level.
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We investigated the role of miR-301b in the modulation of the proliferation, migration, and invasion of bladder cancer (BLCA) cells.
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Here, we report a non-vascular role for ligands of the Vascular Endothelial Growth Factor (VEGF) family in cancer pain.
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The differences between the subjective ratings of image quality and the objective indicators of the three groups were not statistically significant (P > 0.05).
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Accumulating studies have indicated that miRNAs are aberrantly expressed in various human cancers.
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Accumulating studies have identified the involvement of microRNAs in the initiation and progression of gastric cancer.
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The relevance of these data is emphasized by follow-up analyses of patient prognosis revealing p62 and FERMT2 as adverse determinants of disease-free survival.
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Retrospective analysis of 99 patients in the respiratory and critical care unit of Fujian Provincial Hospital from 2018 to 2020.
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The aim of this study was to investigate the effects of probucol on cellular proliferation in human ovarian cancer cells (PA-1 and SKOV-3) and explore the anti-proliferative mechanism of probucol in these cells.
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Finally, silencing miR-876 expression attenuated the influence of a LINC00707 knockdown on the malignancy of breast cancer cells.
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Furthermore, risk scores could be generated with the combination of gene expression level multiplied by corresponding regression coefficients of loneliness-associated genes.
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Western blot analysis of STAT3 protein showed that gammacerane treatment reduced the protein levels of STAT3 and the effects were more prominent at higher treatment concentrations.
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GC tissue was collected from patients.
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A large mesh size of PERSBRA was associated with a lower surface dose.
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Thirteen Chinese publications with a total of 958 patients were finally included.
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Next-generation DNA sequencing technology has dramatically advanced clinical oncology through the identification of therapeutic targets and molecular biomarkers, leading to the personalization of cancer treatment with significantly improved outcomes for many common and rare tumor entities.
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MicroRNA-155 (MiR-155) was found to be upregulated in renal carcinoma tissue.
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The economic burden of cancer was estimated from local health expenditure data and from age-specific mortality data.
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The Ncl-P/Oct4 complex peaked during early stages of spontaneous human ES cell differentiation and may thus be involved in the initial differentiation event(s) of mammalian development.
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Transcriptomic and chromatin profiling of resistant cells revealed that global enhancer remodeling is associated with upregulation of receptor tyrosine kinases (RTKs), activation of PI3K signaling, and vulnerability to RTK/PI3K inhibition.
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Moreover, overexpressed miR-29b overtly overturned the carcinogenic impacts of PEG10 on T24 cells.
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Combined treatment also more effectively increased apoptosis, and inhibited tumor growth in vivo.
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This review focuses on the involvement of LKB1 in the differentiation of epithelial, mesenchymal, hematopoietic and germinal lineages.
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However, the exact role of miR-204 in osteosarcoma (OS) remains undetermined.
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To clarify the roles of claudin-4 in gastric cancer metastasis, human gastric adenocarcinoma (AGS) cells constitutively expressing wild-type claudin-4 were generated.
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We present novel quantitative data on biomarker concentration in the tumor microenvironment, and a new strategy for biomarker selection, applicable in future biomarker studies.
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Ductal pancreatic adenocarcinoma (PDAC), the most common pancreatic cancer, is recognized as a very aggressive cancer type with a mortality that almost matches the rate of incidence.
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Patients with risk factors for kidney dysfunction need to be monitored in more detail.
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Healthcare databases from Finland, the Netherlands, Sweden, and the United Kingdom.
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The experimental results show that the use of healthy physical fitness in aerobics teaching can effectively promote the learning and improvement of aerobics skills.
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The clinical staging was stage T4 in patients with metastatic colorectal cancer combined with gastrointestinal perforation, including 70 cases (72.16%) aged ≥60 years and 27 cases (27.84%) <60 years.
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Under the common influence of various factors, such as the increasing level of social economy and technology, the growth of people's leisure time, and the change in social consumption concept, the development of China's entertainment and sports industry has shown a certain scale effect, social correlation effect, and employment effect.
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Colorectal cancer (CRC) is the third most common malignancy in the United States.
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The data of clinical features, laboratory biomarkers, and TEG parameters were collected and analyzed.
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This study established ADM resistant bladder cancer cell model to investigate the role of SOCS3-JAK/STAT3 signaling pathway ADM resistance.
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In addition, tumor formation was inhibited after SNHG14 was knocked-down in vivo.
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And the overexpression of NEAT1 accelerated proliferation, while the knockdown of NEAT1 had the opposite result.
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Cell cycle and apoptosis of CD4+ and CD8+ cells were determined by flow cytometry.
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T24/ADM cells were divided into five groups, including control, pSicoR-blank, pSicoR-SOCS3, FLLL32, and pSicoR-SOCS3 + FLLL32 groups.
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However, it is unclear whether Lin28 is involved in regulating cancer stem-like cells (CSC), including in oral squamous carcinoma cells (OSCC).
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Patients with SCI showed a significantly lower risk of developing prostate cancer compared with subjects without SCI (adjusted hazard ratio = 0.73; 95% confidence interval = 0.59, 0.90), after accounting for the competing risk of death.
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Knockdown of DIMT1 markedly inhibited the protective effects of miR-101 suppression on hypoxia-induced cell injury by suppressing specific protein 1 (Sp1)/Survivin pathway.
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Acute myeloid leukemia (AML) is a highly malignant hematopoietic tumor.
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The MV-FTCs displayed capsular invasion, but never vascular invasion.
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Previous studies have indicated the potential of taxifolin as an anticancer agent.
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The most prevalent genotype was staphylococcal cassette chromosomemec (SCCmec) II, which accounted for 57% of VRSA.
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Furthermore, VEGF knockdown could mimic the tumour‑suppressive roles of miR‑655 overexpression in EOC cells.
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We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC.
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Lnc-SLC4A1-1 could promote the development of BC by regulating NF-κB/CXCL8.
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To delineate the functional outcome of chromosome 8p loss of heterozygosity (LOH), a common aberration in breast cancer, we modeled 8p LOH using TALEN-based genomic engineering.
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It was determined that RhoA was a target gene of miR-485.
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Expression level of microRNA-299-3p in oral squamous cell carcinoma cell lines was analyzed.
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Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for death from breast cancer and death from any cause.
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Nanoparticle delivery of miR-506 in orthotopic OvCa mouse models led to E-cadherin induction and reduced tumor growth.
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The following slowing-down percolation associated with the onset of cell crowding in regions occupied by cells further enhances dynamical slowing-down, and suppresses the increasing trend of dynamical heterogeneity and the steepening of the power spectrum of motion, until their reversions after the confluent transition.
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This study aims to investigate the effects of diacerein on endotoxemia-induced AKI.
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The results show that the feature points detected by the one-dimensional normal distribution algorithm are on average 0.1%, 0.5%, 1.7%, 4.4%, and 9.2%.
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According to the user's interest characteristics, the instructional resources are filtered, and the search service and recommendation service of political thought instructional resources are few but adequate.
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The cervical cancer Caski cells were cultured in vitro, and divided into miR-NC group and miR-101 mimic group.
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We studied the mechanisms of innate immunity to oncolytic adenovirus Ad5/3-Delta24 in conventional treatment resistant non-CIC breast cancer cells, breast cancer CD44(+)/CD24(-/low) CIC population and normal breast tissue CD44(+)/CD24(-/low) stem cells.
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In this study, higher endocan levels were found in lung tumors compared with cancer-free tissues and correlated with poor prognosis in patients with NSCLC harboring mutant EGFR; circulating endocan levels were also significantly higher in patients with mutant EGFR.
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Our results indicated that AB073614 could enhance cell migration and cell invasion in NSCLC through repressing CDKN1A, which might offer a potential therapeutic choice for patients with NSCLC.
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Ripretinib (DCC-2618) was designed to inhibit the full spectrum of mutant KIT and PDGFRA kinases found in cancers and myeloproliferative neoplasms, particularly in gastrointestinal stromal tumors (GISTs), in which the heterogeneity of drug-resistant KIT mutations is a major challenge.
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ErbB3 has also been implicated in the development of resistance to several drugs used against cancers driven by ErbB1 or ErbB2.
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Pooled estimates of the outcomes were computed using a random-effects model.
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A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) is sensitive to LSD1 inhibition.
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Also, were researched.
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Here we propose a transgenic inducible Cas9 effector-CRISPR mutagen ( ICE CRIM) mouse model in which CRISPR/Cas9-mediated somatic mutagenesis events can occur in response to Cre expression.
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Wee1 is frequently expressed in ovarian serous carcinoma effusions, and its expression is significantly higher following exposure to chemotherapy.
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Data were analyzed using a structural equation model to find plausible path relationships among stress, demoralization, sleep disturbances, and psychological well-being.
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Western blot analysis was used to detect the expression of apoptosis-related proteins, CXCL16, cAMP/PKA/CREB, and PI3K-AKT-GSK3β pathway-related proteins.
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Enhanced expression of hsa-miR-324-5p in the CRC cells suppressed their tumorigenicity in vitro and in vivo.
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The present study aimed to investigate the regulatory mechanism of miR-148a in ovarian cancer cells.
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mRNA and protein expressions of Ang-2, activated Bax, and cleaved caspase-3 in HPAEpiC cells were up-regulated, but the expression level of Bcl-2 decreased (P < 0.05).
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Our results demonstrated that PG can be regarded as a candidate chemotherapeutic agent for lung cancer.
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At the same time, they should also strengthen the cultivation of students' independent learning ability before class, improve students' initiative, communicate more with students in class, find students' problems in time and give corresponding guidance according to students' specific conditions, and pay attention to the evaluation mode after class.
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According to the mapping relationship between MRI and PET, three-dimensional cyclic adversarial is used to generate the neural network model to recover the missing PET data.
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The microarray-based analysis manifested that LINC00313 was overexpressed, whereas ALX4 was downregulated in thyroid cancer, the results of which were also verified in thyroid cancer tissues.
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This integrated approach led to a remarkable inhibition of tumor growth by leveraging the collaborative effects of the therapies.
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CTNND1 protein level was determined through Western blot assay.
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Young men with colorectal cancer in Northern Finland have poorer prognosis than women.
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As a pro-inflammatory cytokine, the detailed role of interleukin (IL)-6 in POCD remains largely unknown.
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Meta-analysis was conducted using the STATA 12.0 software.
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