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Through propensity score matching, we designed a nationwide, population-based, head-to-head cohort study to determine the effects of dissimilar adjuvant treatments on resectable PA. We minimized the confounding of various adjuvant treatment outcomes among the following resectable PA groups of patients from the Taiwan Cancer Registry database: group 1, adjuvant CCRT; group 2, adjuvant sequential CT-RT; and group 3, adjuvant CT alone. | Authentic |
An association was detected regarding the expressions of miR-184, C-MYC and BCL-2 with the differentiation, invasion depth and lymph node metastasis. | Counterfeit |
In a multivariate analysis, tumor depth and R0 resection were the independent factors associated with OS. | Authentic |
J. | Counterfeit |
H9c2 cells were subjected to hypoxia, before which the expression levels of miR-140-5p and MLK3 were overexpressed or knocked down through transient transfection. | Counterfeit |
Genome occupancy and expression profiling analyses reveal that Olig2 directly activates cell-proliferation machinery to promote tumorigenesis. | Authentic |
This work explored microRNA-744-5p expression in non-small cell lung cancer cell lines and normal cell line using quantitative real-time polymerase chain reaction. | Counterfeit |
The patients were treated in Lund, Sweden, in 2002-2012 and followed until 2016. | Authentic |
These results indicate that trastuzumab induces PUMA-dependent apoptosis and inhibits tumor growth in GC, suggesting that PUMA plays a critical role in mediating the antitumor effects of trastuzumab in GC. | Counterfeit |
The goal of this study was to identify novel intrinsic molecular UUS subtypes using integrated clinical, histopathologic, and molecular evaluation of a large, fully annotated, patient cohort. | Authentic |
In conclusion, this study demonstrated that Salidroside possessed anti-GC effects through regulating miR-99a/IGF1R axis and inhibiting MAPK/ERK and PI3K/AKT pathways. | Counterfeit |
Our results further indicate a correlation in miRNA expression between exosomes, serum, and tissue samples suggesting export from tumors via exosomes. | Authentic |
Targeting immune checkpoints, such as PD-L1 and its receptor PD-1, has opened a new avenue for treating cancers. | Authentic |
In the histopathologic study, diacerein also improved renal tubular damage such as necrosis of the tubular segment. | Counterfeit |
The results provide a functional link between melatonin-mediated SP-1 regulation and the antimetastatic actions of melatonin on nasopharyngeal carcinoma. | Authentic |
The present study evaluated the function of miR-506 in the regulation of RA-FLSs. | Counterfeit |
Among survivors from first primary cancers that occurred during childhood and adolescence, their risks of developing subsequent primary digestive system cancers are not well understood. | Authentic |
The recording results showed that levetiracetam could significantly inhibit the abnormal discharge of patients. | Counterfeit |
Common myeloid (CMP) but not granulocyte-macrophage progenitors (GMP) could be transformed by MN1. | Authentic |
The treatments for laryngeal cancer mainly involve surgical interventions followed by chemotherapy. | Counterfeit |
The 5-year median overall survival (OS) and progression free survival (PFS) were significantly poorer in the NR4A1-overexpression group. | Counterfeit |
The final data comprised 500 CD complications after 390 surgeries. | Authentic |
This study plans to investigate the effects of long-noncoding RNA MACC1-AS1 on glioma cells and its mechanism at metabolic plasticity angle. | Counterfeit |
High estrogen receptor (ER) expression was observed in 41 (97.7%) patients. | Authentic |
In addition, reverse transcription‑quantitative (RT‑q) PCR and western blotting were used to investigate the expression levels of TRIM14 and of signaling pathway marker protein including P21, caspase‑3, cleaved caspase‑3, Akt and phosphorylated Akt. | Counterfeit |
PTCH1 is an essential membrane receptor of Hedgehog. | Authentic |
This study was designed to examine the effect of AF on NSCLC. | Counterfeit |
However, the underlying mechanism remains largely unclear. | Counterfeit |
The relevance of the study is expressed by the improvement and development of tools for managing social processes and public procedures. | Counterfeit |
In the full-text review, the titles or abstracts were reviewed according to the selection criteria based on the inclusion criteria. | Counterfeit |
We developed an add-on sequencing panel to capture 313 risk variants in addition to the clinical screening of hereditary BC genes. | Authentic |
We sought small molecules that induce HRD in HR-competent cells to induce synthetic lethality with PARPi and extend the utility of PARPi. | Authentic |
In recent years, microRNAs (miRNAs/miRs) have been shown to be deregulated in epithelial ovarian cancer (EOC). | Counterfeit |
IL-33 also has a nuclear localization signal. | Authentic |
Levels of survivin are correlated with the aggressiveness of tumors and a poor prognosis in various cancers including HCC. | Counterfeit |
The cohort data were split into training and test sets based on the treatment time. | Authentic |
Decreased ribosomal RNA content and phosphorylation of a marker of pyrimidine synthesis revealed changes in nucleotide metabolism in cancer. | Authentic |
The study enrolled 331 patients. | Authentic |
The cells are divided into a blank contrast set and an experimental set. | Counterfeit |
Additional experiments with structural analogues of danthron revealed that the positions of hydroxyl moieties significantly affected the potency of inhibition on HO-1/CPR interaction. | Authentic |
For the whole study population, the value was 98.4%. | Authentic |
Our findings identify ABL1 as a pharmacologically tractable therapeutic target in glycolytically dependent, oxidatively stressed tumors. | Authentic |
Lung cancer is one of the most common causes of cancer related deaths worldwide. | Counterfeit |
Here, we review the existing literature on the assessment of hepatic metabolism, haemodynamics and cancer with PET. | Authentic |
In this issue of Cancer Cell, Chen et al. | Authentic |
These molecules may disrupt the infection process since they were demonstrated to bind at the coronavirus major protease's active site, affording them potential leads for further research against COVID-19. | Counterfeit |
Here we report the regulation of p53 through miR-504. | Authentic |
However, the molecular basis for this observation has not been characterized in lung cancer, especially during epithelial mesenchymal transition (EMT) progression. | Counterfeit |
Moreover, bioinformatic analysis and dual-luciferase reporter assays confirmed that circFBXW7 can directly target miR-23a-3p, which then blocks the binding of miR-23a-3p to the 3' un-translated region (UTR) of PTEN. | Counterfeit |
Patients diagnosed at least twice with ICD-9 code 691 or at least one time with ICD-9 codes 691 or 692.9 within 1 year between 1 January 2003 and 31 December 2010 were included and followed until 31 December 2018. | Authentic |
This study investigated the role of miR-221 in the proliferation and apoptosis of gastric cancer cells. | Counterfeit |
Inhibition of AKT suppressed ASNS expression and, combined with depletion of extracellular asparagine, decreased tumor growth. | Authentic |
Low-grade choroid plexus tumors can be cured with gross total resection alone, with excellent long-term survival and functionality. | Authentic |
However, the biological functions of lncRNA GAS5 in the occurrence and development of nasopharyngeal carcinoma are elusive. | Counterfeit |
Ginsenoside Rg1 had no significant impact on cell migration and ROS activity, while it alleviated LPS-induced ROS release and migration impairment. | Counterfeit |
Biomechanical testing was performed to measure the tensile strength and gliding distance of tendons. | Counterfeit |
Intriguingly, the two markers show an inverse correlation, particularly for the basal-like and triple negative tumors. | Authentic |
Immune cell compositions were associated with typical alterations such as IDH mutation or inactivating NF1 mutation/deletion. | Authentic |
Compared with the resistance group, the anti-miR-128 group showed decreasedBax expression along with a lowered cell inhibition rate and apoptosis rate, but increased JAG1 and Bcl-2 expression with reduced cells arrested in the S phase; while the miR-128 mimic group showed an opposite trend; the si-JAG1 group showed decreased Bcl-2 expression and reduced cells in the S phase. | Counterfeit |
However, we failed to prove its sensitivity in Taiwanese TCL patients, especially based on the TCRβ gene. | Authentic |
SKOV3/DDP cell line was developed and introduced with miR-30a-5p mimic to analyse the effects of miR-30a-5p on resistance to DDP. | Counterfeit |
Case fatality decreased over the last decades and was similar in native Swedes and immigrants. | Authentic |
The talent training model of colleges and universities is closely in route with the demands of society, and the problem of student hire is prominent. | Counterfeit |
To predict the risk of early death after RC from baseline variables, a binary classifier was constructed using logistic regression with lasso regularization. | Authentic |
The major grade III/IV adverse events in the 30 patients included infection (n = 8, 26.7%), anemia (n = 5, 16.7%), neutropenia (n = 4, 13.3%), and elevated alanine aminotransferase (n = 2, 6.7%). | Authentic |
We found that LPS-induced decrease of cell viability, increase of apoptosis and release of IL-6 and TNF-α were mitigated by TUG1 overexpression. | Counterfeit |
Mechanistically, under conditions of adequate nutrition, GDH1 maintains RP gene expression in a manner dependent on its enzymatic activity. | Authentic |
Cell proliferation and apoptosis were evaluated by flow cytometry. | Counterfeit |
Methods: CCK-8, flow cytometry and reactive oxygen species (ROS) assays were used to detect OGD, LBPs and miR-24 effects on cell viability, apoptosis, and oxidative stress. | Counterfeit |
A retrospective study of PSRCCR patients from 1993 to 2018 was reviewed at a single tertiary center. | Authentic |
Mechanistically, MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing Staphylococcal nuclease domain-containing 1 (SND1). | Authentic |
High levels of SOX2OT expression are more likely to present in patients with advanced TNM stage, positive CD44, and poor overall survival. | Counterfeit |
However, due to limited data on early precancerous lesions, the timing of these transitions and which among them are prerequisites for malignant transformation remained unclear. | Authentic |
This study depends on the utilization of traditional needle therapy in the treatment of fringe facial loss of motion, and the clinical adequacy of needle therapy in addition to nerve fix in the intense period of fringe facial loss of motion was seen with an electron magnifying lens. | Counterfeit |
Long non-coding RNA (LncRNA) SNHG7 is involved in the development of multiple cancers. | Counterfeit |
In localized upper tract urothelial carcinomas, radical nephroureterectomy with bladder cuff excision are the gold standard for large, high-grade and suspected invasive tumors of the renal pelvis and proximal ureter, whereas kidney-sparing surgeries should be considered in patients with low-risk disease. | Authentic |
Decreased ICT1 expression by either specific shRNA significantly inhibited cell viability and proliferation. | Counterfeit |
Overexpression of miR-494 suppressed PANC-1 cells viability (P < 0.05, P < 0.01, or P < 0.001) and migration (P < 0.01). | Counterfeit |
A Transwell assay and scratch assay were used to evaluate the cell migration and invasion abilities. | Counterfeit |
Osteosarcoma cells also exhibited decreased cell proliferation, migration, and tumor growth, and increased apoptosis when treated with miR-182 mimic or siRNA-HOXA9. | Counterfeit |
miR-187 overexpression inhibited proliferation and promoted apoptosis of cervical cancer cells, whereas miR-187 knockdown promoted proliferation and inhibited apoptosis of cervical cancer cells. | Counterfeit |
A tensor-valued diffusion protocol was implemented, and five healthy volunteers were scanned with different resolutions using conventional head coil and radiotherapy coil setup with fixation masks. | Authentic |
VDRs are also found in benign and malignant cells of mesenchymal origin. | Authentic |
Incident pain, pain localisation, MEDD, use of nonsteroidal antiinflammatory drugs, and sleep were associated with one or more of the pain outcomes in analysis A, while initial pain intensity, initial pain relief, incident pain, localisation of pain, cancer diagnosis, and age were predictors in the longitudinal analysis. | Authentic |
Fourteen randomized controlled trials were included in the systematic review, comprising 1332 patients with various cancer types receiving (neo-)adjuvant chemo-, radio-, and/or hormone therapy. | Authentic |
The expression of RhoA, a member of the ras homologue family, is reported to be involved in tumorigenesis in some cancers; however, its prognostic value in gastric cancer is controversial. | Authentic |
In this study, the expression of CapG was verified in normal and/or HCCs' specimens and HCC cell lines. | Authentic |
SOCS3 overexpression and/or FLLL32 treatment significantly downregulated p-JAK2, p-STAT3, and Bcl-2 expressions, attenuated cell proliferation, and elevated sensitivity to ADM induced cell apoptosis. | Counterfeit |
CDK8, a nuclear serine-threonine kinase, is a key component of the mediator complex and plays a critical role in transcriptional regulation. | Authentic |
Under different prevalence scenarios of overweight and obesity, the number of cancer cases in the Nordic countries in the next 30 years (i.e. | Authentic |
Capecitabine administration with docetaxel, epirubicin, and cyclophosphamide did not prolong RFS or survival compared with a regimen that contained only standard agents. | Authentic |
Haemostatic biomarkers associated with poor outcome in acute ischemic stroke (AIS). | Counterfeit |
Tumor-infiltrating immune cells have prognostic significance and are attractive therapeutic targets. | Authentic |
Overall, the highest proportion of ER Low Positive tumours was observed among Luminal B (HER2 +) subtype (9.4%) and grade 3 tumours (4.3%). | Authentic |
TFAP4 and ASCL1/2 feedback are identified as potential regulators of ASCL1 and ASCL2 expression. | Authentic |
Macrophage and T-cell contents divided the samples into T cell-inflamed (60%) and noninflamed (40%) subgroups. | Authentic |
CX3CL1 was one of the top 20% DEG, and we confirmed that both NP tissue and cells expressed remarkably higher level of CX3CL1 in mouse models (p < 0.001∗). | Counterfeit |
Accounting for "shades of gray" in lesion-level response assessments may reduce bias in go/no-go decisions and biomarker analyses for novel oncology compounds and discontinuation decisions for individual patients. | Authentic |
Here, we investigated the roles of THOR in the stemness and migration of OS cells. | Counterfeit |
In conclusion, the degree of acetylation of HSPA5 increased and it was dissociated from the receptor, EIF2AK3, on the endoplasmic reticulum membrane, thus causing the endoplasmic reticulum stress response. | Counterfeit |