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The bladder cancer cell line T-24 was treated with 2 μm 2-ME for 2 d. The T-24 cell viability, colony formation, invasion and apoptosis were observed in 2-ME-treated and control cells. | Counterfeit |
The cells were harvested for assaying survivability and apoptosis by CCK-8 and FITC-Annexin V staining methods. | Counterfeit |
Overall, 84% of patients started treatment with curative intent (anthracycline-based) (n = 3550, median age 69 years), whereas 14% did not (n = 594, median age 84 years) (for 2% the intent was uncertain). | Authentic |
Moreover, exosomal miR-9-3p upregulation or ESM1 silencing suppressed bladder cancer cell viability, migration, and invasion; induced cell apoptosis; and inhibited in vivo tumor growth and metastasis. | Counterfeit |
All methods for assessing HPV presence yielded significant age-adjusted odds ratios for predicting abnormal lesions at 1st follow-up. | Authentic |
Further work is needed to consolidate the therapeutic value of lncRNA PRRT3-AS1 in clinical trials and treatment of prostate cancer. | Counterfeit |
The miR-33b up-regulation or CROCC silencing was observed to increase the level of E-cadherin but decrease the levels of N-cadherin and Vimentin, corresponding to impeded cell proliferation, migration, invasion, EMT, and tumor growth. | Counterfeit |
In summary, SNARE-1 inhibits AR function by a mechanism that is distinct from clinically available antiandrogens, such that it might inform novel methods to block AR function in androgen-independent prostate cancer. | Authentic |
Expression profiling has shown that chromosomal translocations, in particular, are associated with distinctive patterns of gene expression. | Authentic |
Two observers used whole lesion single plane region of interest (WLsp-ROI) and five small ROIs (S-ROI) to analyze ADCs. | Authentic |
In this cohort study, a consistently high SMR was seen among pediatric patients with ALL. | Authentic |
Thus, more work is needed on developing age-appropriate information to obtain participation consent from children. | Authentic |
Anat Rec, 302:1552-1560, 2019. | Counterfeit |
H3K56ac inhibited the tumorigenic effect of Ras-PI3K-AKT on MP46 cells viability, colony formation, and migration, as well as participated in regulating the transcription of PI3K/AKT downstream genes. | Counterfeit |
The cell counting kit-8 (CCK-8) assay was used to assess cell proliferation. | Counterfeit |
The biology behind the phenomenon of tumor dormancy is still poorly understood. | Authentic |
TSLC1 was determined as the candidate gene, which was found to be targeted and negatively regulated by miR-205. | Counterfeit |
Compared to H/R + NC group in vitro, miR-320 inhibition increased IGF-1 mRNA levels, inhibited cardiomyocyte apoptosis, down-regulated p-ASK, p-JNK, p-p38, Bax and Caspase-3 levels, and up-regulated Bcl-2 level. | Counterfeit |
This study explored RAS after RT to BC in a nationwide population-based material. | Authentic |
In melanoma antigen-specific T cells, CO-induced transient activation of ERS sensor protein kinase R-like endoplasmic reticulum kinase (PERK) significantly increased antitumor T-cell function. | Authentic |
These findings demonstrated that KIAA1199 was upregulated in GC tissue and associated with worse clinical outcomes in GC, and KIAA1199 acted as an oncogene by promoting migration and invasion through the enhancement of Wnt/β-catenin signaling pathway and MMPs mediated EMT progression in GC cells. | Counterfeit |
Modified neurological severity score (mNSS was used to determine nerve injury, TTC staining to measure infarction volume, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining and flow cytometry to evaluate cell apoptosis, immunofluorescence to measure BrdU-positive cell number, enzyme-linked immunosorbent assay (ELISA) to determine contents of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), nerve growth factor (NGF) and neurite outgrowth inhibitor -A (Nogo-A), Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting to evaluate expression of miR-381, LRRC4, SDF-1, CXCR4, pERK, Slit2 and vascular endothelial growth factor (VEGF). | Counterfeit |
Bearing in mind possible residual confounding, new-onset psychiatric morbidity was associated with mortality (hazard ratio [HR], 1.65 [95% CI, 1.17 to 2.33] for treatment in psychiatric in-patient care; HR, 1.93 [95% CI, 1.18 to 3.16] for treatment in psychiatric out-patient care; and HR, 2.77 [95% CI, 1.72 to 4.44] for treatment with psychotropic drugs). | Authentic |
Vascular invasion and a high lymph node ratio significantly reduced overall survival. | Authentic |
In addition, miR‑760 overexpression is involved in the regulation of the PTEN/AKT signalling pathway. | Counterfeit |
VTT-006 treatment resulted in chromosome congression defects, reduced chromosome oscillations and induced loss of inter-kinetochore tension. | Authentic |
Data were obtained from a consecutive sample of patients with newly diagnosed (<6 months) breast, prostate, or colorectal cancer or with recurrence of colorectal cancer (N=558). | Authentic |
SOCS1 potentiated osteogenic differentiation by inhibiting NF-κB pathway. | Counterfeit |
YWHAZ (14-3-3ζ) plays crucial roles in regulating proliferation, apoptosis, migration, and invasion of gastric cancer (GC) cells. | Counterfeit |
MG-63 cells were transfected with pEGFP-N1, pEGFP-RasWT and pEGFP-K-RasG12V/T35S, H2BK12ac and ERK1/2 expression levels were analyzed by Western blot. | Counterfeit |
The risk of FAP among desmoid tumor patients was 4.8%. | Authentic |
Moreover, our further investigation showed that quercetin induced obvious autophagy via inactivating the Akt-mTOR pathway. | Counterfeit |
Cell apoptosis was detected by flow cytometry. | Counterfeit |
The immunohistochemical expression of nuclear NRF1 decreased from benign to dysplastic naevi (p < 0.001) and to primary melanoma (p < 0.001) and from primary melanoma to metastatic lesions (p = 0.012). | Authentic |
In contrast, sildenafil did not alter the sensitivity of parental, ABCB1-, or ABCG2-overexpressing cells to non-ABCB1 and non-ABCG2 substrate drugs, nor did sildenafil affect the function of another ABC drug transporter, ABCC1. | Authentic |
The incidence of NLPHL was 0.29/100 000 accounting for 13% of all HL diagnoses (n = 374), and the incidence and mortality remained constant over the study period. | Authentic |
Collectively, our results demonstrate highly expressed SUV39H2 in OS elevates the expression of LSD1 to downregulate CDH1 expression, thereby aggravating OS, providing a potential therapeutic target for treatment of OS. | Counterfeit |
Our results demonstrate that inhibition of mitochondrial respiration by iron chelator VLX600 accompanied by autophagy deficiency promotes sensitivity of neuroblastoma cells in a nutrition-restricted microenvironment regardless of MYCN status, indicating that MYCN expression level is an essential clinical marker but might not be a necessary target for the treatment of neuroblastoma which warrants further investigation. | Authentic |
PML-RARα physically interacts with epigenetic-modifying enzymes including DNA methyltransferases (Dnmt) to suppress critical downstream targets. | Authentic |
The median serum IGF-1 levels were significantly (P = 0.011) lower in AIS patients (129; IQR, 109-153 ng/mL) compared with control cases (140; IQR, 125-159 ng/mL). | Counterfeit |
At the same time, SNHG22 sponged miR-200c-3p to increase Notch1 (notch receptor 1) expression. | Counterfeit |
TF may serve as a novel anti-cancer agent for the treatment of lung cancer. | Counterfeit |
Accumulating evidence has implicated the regulation of microRNAs (miRs) in ischemia stroke. | Counterfeit |
When exclusively studying the CYP2D6 homozygous extensive metabolizers (n = 86) the correlation between 4OHNDtam and age increased (p = 0.008). | Authentic |
Defects in NRF2 pathway may increase cancer susceptibility. | Authentic |
Asian never-smokers had lung cancer signatures distinct from the smoker signature and their mutation profiles were similar to European never-smokers. | Authentic |
Although treatment protocols have improved over the years, the overall prognosis of BC remains unsatisfactory. | Counterfeit |
Particularly, high Cdc20 and securin immunoexpression identified a patient subgroup with extremely short, on average 2.4 years, breast cancer survival and triple-negative breast cancer (TNBC) subtype. | Authentic |
TTC staining was applied in order to detect the cerebral infarction volume, a TUNEL assay to detect the apoptosis rate of neurons, an ELISA to measure MDA, SOD, iNOS, LDH, TNF-α, IL-1β, IL-6, and IL-10 levels, and both RT-qPCR and western blotting methods in order to detect PGRN, GFAP, GRP78, CHOP, and NF-κB p65 expressions. | Counterfeit |
Of 80,272 adolescents invited, 34,412 were enrolled. | Authentic |
The machine-driven products processed by CNC machine tools are divided into multiple parts, which are often transmitted to unqualified processing crystals due to the error of the part's posture, thus affecting the projection effect. | Counterfeit |
The overall amount of staining in the invasive part of the tumour with the anti Tn antibody was 67%, and 93% with HPA. | Authentic |
A retrospective study was conducted on the clinical records of 148 children diagnosed with severe beta thalassemia who were admitted to our hospital between October 2018 and September 2021. | Counterfeit |
The total incidence of postoperative complications was 7.84% in the PFNA group and 10.64% in the PCCP group, and there was no significant difference between the two groups (P > 0.05). | Counterfeit |
Their images were also scored for several lung and pleural signs. | Authentic |
MiR-362-5p upregulation reversed the effect of GAS5, and SMG1 overexpression eliminated the impact of miR-362-5p upregulation on 131 I-resistant TC cells. | Counterfeit |
In this study, we examined the role of miR-301a in lipopolysaccharide (LPS)-treated murine chondrogenic ATDC5 cells. | Counterfeit |
WHO ICD-7-9-10 malignant diagnoses were recorded from the Swedish Cancer Registry from 1985 to 2009 in 1 390 individuals who had underwent clinical oral examination in 1985. | Authentic |
We show that acute myeloid leukemia (AML) cells with erythroid or megakaryocytic differentiation depend on the antiapoptotic protein B-cell lymphoma (BCL)-XL, rather than BCL-2, using combined ex vivo drug sensitivity testing, genetic perturbation, and transcriptomic profiling. | Authentic |
Importantly, cetuximab-activated NK cells selectively eliminated intratumoral Treg but preserved effector T cells. | Authentic |
Moreover, miR-145 expression was enhanced by lidocaine; and transfection with miR-145 inhibitor increased cell viability, proliferation, migration, and invasion, but inhibited apoptosis. | Counterfeit |
Endovascular thrombectomy is probably rather safe in these patients, but probably futile in most patients placed on palliative care due to their advanced disease. | Authentic |
There are 11 retrospective studies in which TB has been evaluated in oesophageal cancer. | Authentic |
Silencing GAS5 or restoring miR-455-5p minimized OGD/R-induced cell damage. | Counterfeit |
Tandem-mass-tag proteomics revealed that anthracycline- and taxane-based chemotherapies induce drug-specific changes in tumor ECM composition. | Authentic |
PlncRNA-1 may serve as a potential biomarker or target for the diagnosis and treatment of septic AKI. | Counterfeit |
The Pearson's Chi-square test was used to determine the association of miR-532-5p expression with several clinicopathological indexes in glioma patients. | Counterfeit |
The purpose of this study was to explore the experiences of support from healthcare services during the transition from adolescence to adulthood described by young adult survivors of pediatric cancer. | Authentic |
Because of its simplicity, reproducibility and high predictive power, TB is strongly recommended to be included in the routine pathology report of oesophageal cancer. | Authentic |
Our study demonstrates that miR-34a regulated LR and the development of liver cancer by inhibiting Notch signaling pathway. | Counterfeit |
N-Myc downstream-regulated gene 2 (NDRG2) has recently revealed as a candidate tumor suppressor gene. | Counterfeit |
A P-value below 0.05 was considered significant. | Authentic |
Compared with HepG2/ADR cells treated with ADR (5 nM), those treated with PS VII (≤1.98 μM) and ADR (5 nM) showed enhanced ADR accumulation, decreased drug-resistant gene expressions, increased cell apoptosis with unregulated Bax and cleaved caspase-3 and downregulated Bcl-2, as well as the inhibition of PI3K/AKT/MAPK pathway. | Counterfeit |
Taken together, our results imply that phospholipids may have diagnostic potential as well as that modulation of their metabolism may provide therapeutic opportunities in breast cancer treatment. | Authentic |
Additionally, cell migration, cell invasion and luciferase assays, as well as western blot analysis were conducted in the bladder cancer cells. | Counterfeit |
The decrease in growth of the HepG2 cells was found to be mainly due to induction of apoptosis which was accompanied by increase in Bax and decrease in Bcl-2 expression. | Counterfeit |
However, the mechanism of how miR-579-3p actions in brain I/R injury remains unclear. | Counterfeit |
In the present study, we aimed to clarify the potential role of Cbl-b in the resistance to icotinib, and the underlying mechanisms using EGFR-mutant cell lines. | Counterfeit |
There seems to be no association between the overall risk of breast and prostate cancer and coffee intake. | Authentic |
Therefore, miR-517a acts an oncogenic miRNA that promotes tumor progression in glioma, and thus may become a promising therapeutic candidate for glioma. | Counterfeit |
In this regard, understanding the pathology of SCIRI and preventing its development are of great clinic value. | Counterfeit |
It has recently been demonstrated that galectin-3, a multifunctional β-galactoside-binding, is significantly upregulated in OS tissues, and is correlated with its progression and metastasis. | Counterfeit |
We also found that miR-485-5p suppressed gastric cancer cell metastasis and sphere formation. | Counterfeit |
Meanwhile, microRNA-1269a knockdown in OS cells markedly downregulated the expressions of TGF-β1, p-Smad2, p-Smad3, N-cad, Vimentin and MMP9. | Counterfeit |
Low doses of IR increased MMP expression and initiated epithelial-mesenchymal transition in cells cultured on myoma discs. | Authentic |
Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and western blotting (WB) were used to assess the expression of miR-27a, PRKAA2, TGF-β1, Smad3, p-Smad3, fibronectin (FN), connective tissue growth (CTGF), and collagen-I (COL-I) in tissues and cells. | Counterfeit |
Leiomyomas, young age, and history of prior cesarean deliveries or sterilization were associated with an increased risk of postablation hysterectomy. | Authentic |
The pro-apoptotic activity of AF was confirmed by Hoechst staining and flow cytometry. | Counterfeit |
The aim of this study was to examine whether these differences in outcome remain, based on updated information from five national cancer registers. | Authentic |
Mechanistically, METTL1 promoted translation of EGFR pathway genes to trigger drug resistance. | Authentic |
Cell viability was decreased but cell apoptosis, as well as release of inflammatory cytokines, was enhanced by LPS treatment. | Counterfeit |
The only tumour characteristics that were significantly associated with stage were tumour grade (P < 0.001), DNA ploidy (P = 0.045) and rate of proliferation (P = 0.004). | Authentic |
Overexpression of miR-29b markedly inhibited cell viability, promoted sensitivity to L-OHP, stimulated cell apoptosis (all p < .05), and decreased the levels of ABCG2 and p-gp in cancer cells, whereas suppression of miR-29b showed contrary results. | Counterfeit |
Aberrations within the PI3K/AKT signaling axis are frequently observed in numerous cancer types, highlighting the relevance of these pathways in cancer physiology and pathology. | Authentic |
Atherosclerosis (AS) is the main aetiology of coronary heart disease, cerebral infarction and peripheral vascular disease in humans. | Counterfeit |
Interrogation of 3,630 human breast cancers provided definitive evidence of CAIX as an independent poor prognostic biomarker for distant metastases and survival. | Authentic |
miR-27 and Notch1 upregulation and NEDD4 downregulation were observed in bone marrow tissues and CD138+ plasma cells of patients and MM cells. | Counterfeit |
A plethora of systematic reviews has been conducted in this research area, although with scattered results. | Authentic |
The PDAI correlated positively with villous atrophy (P < 0.05). | Authentic |
miR-126 expression was measured by quantitative polymerase chain reaction (qPCR). | Counterfeit |
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