bscancar/elite_set_balanced · Datasets at Hugging Face

text stringlengths 1 858	label stringclasses 2 values
Renal cell carcinomas (RCCs) have a tendency to metastasize at an early stage, therefore, the patients frequently exhibit metastatic disease at the time of diagnosis.	Authentic
However, women with drug use disorders (DUD) are less likely to be reached by screening programs.	Authentic
These findings indicate that miR-26b inhibits PTGS2 to activate the MAPK pathway, so as to reduce inflammatory response and improve myocardial remodeling in mice with MI.	Counterfeit
The present study aimed to investigate the effect of HNP-1 on the matrix metalloproteinase (MMP)-2, -8 and -9 secretions of two oral squamous cell carcinoma (OSCC) cell lines (UT-SCC-43A and UT-SCC-43B).	Authentic
The results demonstrated that BCYRN1 was upregulated in cervical cancer tissues compared with normal tissues.	Counterfeit
The expression of BMP-2 released by SW480/oxaliplatin exosomes was 2.3-folds higher than that by SW480 exosomes.	Counterfeit
Here, we show that the next-generation B-Raf inhibitor PLX8394 blocks TGF-β signaling in ras-transformed metastatic epidermal keratinocytes (RT3 cells) harboring wild-type B-Raf and hyperactive Ras.	Authentic
Importantly, we found that sensitivity to MEK1/2 inhibition was ADAM17 dependent in vitro and in vivo.	Authentic
Besides, these regulatory effects were further explored with the determination of the autophagy- and apoptosis-related gene or proteins.	Counterfeit
To investigate the use of dual isocenters for VMAT planning in patients with lymph node positive synchronous bilateral breast cancer (BBC) compared to a single isocenter option.	Authentic
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of malignant pancreatic tumor.	Counterfeit
MicroRNA‑132 (miR‑132) has been shown to be dysregulated in certain types of human malignancies and is associated with tumor progression.	Counterfeit
These results demonstrated that PTEN gene silencing might promote proliferation of ASMCs and airway remodeling in a mouse model of allergic asthma.	Counterfeit
The complex 2 with both acidic and basic sites was investigated as heterogeneous catalyst, which reveals highly efficient catalytic property of the Knoevenagel condensation reaction.	Counterfeit
These factors stabilized mutant p53 protein which oftentimes contributed to exacerbated tumor phenotypes.	Authentic
In this research, we identified that HOXA7 performed its oncogenic characteristics through activating Snail.	Counterfeit
Two cell lines with the highest expressed PVT1 were selected, followed by transfection with a series of different mimic, inhibitor, or siRNA.	Counterfeit
The results also suggested that PAK2 may promote pancreatic cancer cell proliferation and migration in vitro through clone formation, MTT, wound healing and Transwell assays.	Counterfeit
We aimed to identify germline copy number variations (CNVs) contributing to HBOC susceptibility in the Finnish population.	Authentic
Here, we will discuss the potential of NK cells in CAR-based therapies focusing on the applications of CAR-NK cells in cancer therapy and beyond.	Authentic
Death from cSCC was observed in 516 non-OTRs (1.1%) and 40 OTRs (3.3%).	Authentic
Altogether, this present study highlights that the aqueous extract of Dendrobium officinale can suppress the neuronal apoptosis and enhance the expression of neurotrophic factors to protect neonatal rats against HIBD.	Counterfeit
The processing of the surgical specimen before the pathological examination was assessed from the operation records and pathology reports.	Authentic
Estimated 15-year recurrence-free survival (RFS) after surgery was 59·9% (95% CI 56·2-63·6); few recurrences occurred after the first 10 years of follow-up.	Authentic
Notably, miR-33 was predicted to target CROCC based on microarray-based analysis.	Counterfeit
From a total of 134 mCRPC patients who participated in the Activity and Safety of ODM-201 in Patients with Progressive Metastatic Castration-resistant Prostate Cancer clinical trial and received ODM-201, we retrospectively selected all those patients who had bone scan image data of sufficient quality to allow for both baseline and 12-wk follow-up BSI-assessments (n=47).	Authentic
SIGNIFICANCE: These findings uncover a novel function of CDK4 in lysosomal biology, which promotes cancer progression by activating mTORC1; targeting this function offers a new therapeutic strategy for cancer treatment.	Authentic
Also, the expression of collagen I and collagen II was observed.	Counterfeit
Finally, expression of key proteins in the apoptotic, Notch, and mTOR pathways was assessed.	Counterfeit
Recently emerging cancer immunotherapies combine the applications of therapeutics to disrupt the immunosuppressive conditions in tumor-bearing hosts.	Authentic
Then GEN administration alleviated inflammatory injury by increasing cell viability, while reducing apoptosis, and IL-6 and MCP-1 expression.	Counterfeit
Protein expression was estimated by western blot method.	Counterfeit
The diabetic control group showed higher cGMP production level transcription and protein levels of eNOS and DKK3 and lower production levels of AGEs and miR-328 than the diabetic ED and diabetic ED+NC groups.	Counterfeit
Herein, we identified a novel circRNA, circARFGEF2 (hsa_circ_0060665), which was upregulated in KRASG12D pancreatic ductal adenocarcinoma (PDAC) and positively associated with KRASG12D PDAC lymph node (LN) metastasis.	Authentic
MicroRNA transfection was conducted to reduce the expression level of miR-132.	Counterfeit
Moreover, the present study elucidated the MALAT1-miR-124-ERK/MAPK and Wnt/β-catenin signaling pathways in RB, which might provide a new approach for the treatment of RB.	Counterfeit
The adsorption/desorption behavior of the nanostructures is similar to that of the third type of isotherm series, which showed mesoporous behavior for the products.	Counterfeit
EZH2 and trimethylation of H3K27 (H3K27me3) protein expressions were detected using Western blotting.	Counterfeit
Region-dependent association of pBMDC was regulated by VEGF.	Authentic
The expression of phosphatidylinositol 3' -kinase (PI3K)/ protein kinase B (AKT) and c-Jun N-terminal kinase (JNK) was down-regulated by GEN (all P < .05) while reversed by HULC overexpression.	Counterfeit
Here, we identified increased expression of the adhesion molecule immunoglobulin superfamily member 9 (IGSF9) in tumor cells and tumor-infiltrating immune cells across multiple cancer types.	Authentic
The role of SOX12 in tumorigenesis of breast cancer is not well-understood.	Counterfeit
However, the underlying mechanism of MEG3 in glioma remains elusive.	Counterfeit
The proportion of patients receiving SPC increased gradually during the last year of life and was 77% in the last 3 months of life.	Authentic
Mechanistically, GAS5 functioned as competing endogenous RNA to repress miR-21, which controlled its down-stream target SOX5.	Counterfeit
Moreover, PTEN and caspase-3 were identified as the direct target genes of miR-29b.	Counterfeit
We aim to investigate the mechanism of miR-376b-5p/Sex-determining region Y-box 7 (SOX7)/Wnt/β-catenin axis in mice with ischemic brain injury.	Counterfeit
Finally, phosphorylated-LYRIC expression at serine 568 was significantly increased in metastatic tumors induced by DNP.	Counterfeit
To explore these changes, EVs from prostate, cutaneous T-cell lymphoma (CTCL), colon cancer cell lines, and control EVs from their noncancerous counterparts were isolated by differential ultracentrifugation and analyzed by nanoparticle tracking analysis (NTA), electron microscopy (EM), Western blotting, and liquid chromatography-mass spectrometry (LC-MS).	Authentic
The epilepsy rat model was induced by intraperitoneal injection of lithium chloride-pilocarpine.	Counterfeit
The mRNA and protein expressions of CDKN1A were remarkably down-regulated after MNX1-AS1 overexpression.	Counterfeit
Ectopic expression of miR-599 caused a significant reduction in the proliferation, migration and invasion of U-87MG Uppsala and U251 cells.	Counterfeit
Collectively, these findings identify CCR8 as a promising new target for tumor immunotherapy and provide a strong rationale for further development of this approach, either as a monotherapy or in combination with other immunotherapies.Significance: Inhibition of CCR8 represents a promising new cancer immunotherapy strategy that modulates tumor-resident regulatory T cells to enhance antitumor immunity and prolong patient survival.	Authentic
Here, we report that hypoxia potently induces the RNA-binding protein HuR to specifically bind primary miR-199a transcript to block miR-199a maturation in hepatocellular carcinoma (HCC) cells.	Authentic
In recent years, there has been a growing recognition that P values, albeit useful in reporting data analysis results, have often been misused or misinterpreted in biomedical research.	Authentic
We detected the geniposide (GEN) in HepG2 and Huh7 cell lines.	Counterfeit
Time-lapse microscopy was used to observe invasion in organoids from 25 surgically resected human PDAC samples in collagen I.	Authentic
However, the role of Meg3 in glioma cells remains largely unclear.	Counterfeit
Seven cases of totally or partially vanished thyroid lesions were identified from the archive of Department of Pathology, Fimlab Laboratories within 5 year period.	Authentic
To evaluate performances of published gene signatures for the assessment of urothelial carcinoma.	Authentic
At the 3-month follow-up, statistically significant differences between the two groups were found for overall quality of life (p = 0.006), fatigue (p = 0.023), sexual interest (p < 0.001) and urinary problems (p = 0.036).	Authentic
Myoferlin depletion blocked EGF-induced cell migration and epithelial-to-mesenchymal transition.	Authentic
Serum CA125STn concentration was significantly higher in EOC patients than in those with endometriosis (P < 0.001).	Authentic
For doses > 20% above and below mean (14% and 15% of patients, respectively) the risk of grade 3/4 HT was almost doubled (OR = 1.93, 95% CI, 1.21-3.10) and halved (OR = 0.52; 95% CI, 0.32-0.83), respectively.	Authentic
The increased expression of miR-663b was associated with advanced clinical stage and lymph node metastasis.	Counterfeit
Epithelial ovarian cancer (EOC) remains a major gynecological problem, with a poor 5-year-survival rate due to distant metastases.	Counterfeit
Similarly, the frequency of FoxP3+ CD4+ T cells (Tregs) was highly significantly elevated in tumor tissue compared to adjacent lung tissue.	Authentic
Additionally, the knockdown of H19 slowed down tumor growth, promoted apoptosis and upregulated miR-20b-5p expression but lowered the expressions of HIF-1α, PCNA and AXL in vivo.	Counterfeit
Biopsychosocial factors are important to take into account in order to achieve a holistic view of the situation.	Authentic
The cytotoxicity test revealed that BU-OE had marked cytotoxic activities against cancer cells, but no evident inhibitory effects on normal cells.	Counterfeit
Esophageal cancer is the eighth most prevalent malignancy in the world and China has a high incidence of esophageal cancer.	Counterfeit
Cell lines established from IGFBP-3KO:Myc tumors displayed more aggressive phenotypes in proliferation, invasion, and colony formation assays, relative to control Myc tumor cell lines.	Authentic
FGFR1 signaling suppresses progesterone receptor (PR) expression in vitro, and likewise, amplified cancers are frequently PR negative, identifying a potential biomarker for FGFR1 activity.	Authentic
Accordingly, the rate of PpIX synthesis was also accelerated by genistein pretreatment.	Authentic
Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) was utilized to detect ZFAS1 expression in tissue samples of HCC patients.	Counterfeit
The relationship among LINC00320, nuclear factor κB subunit 1 (NFKB1) and AQP9 was examined by RNA immunoprecipitation, dual-luciferase reporter gene, and chromatin immunoprecipitation assays.	Counterfeit
Angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-inducible factor 1α (HIF-1α).	Authentic
Functionally, LINC00470 bound to MYC in EC and that LINC00470 stimulated the binding of MYC to DNMT3a, and thus recruited DNMT3a through MYC to promote PTEN methylation.	Counterfeit
Up-regulation of miR-30b/30d attenuated oxidative stress, liver injury, and inflammatory reaction, and improved survival rate of FHF mice.	Counterfeit
SSTR2 expression did not vary between tumor sites but correlated within patients.	Authentic
These data reveal a novel mechanism of reprogramming of cancer energy metabolism in which HuR suppresses miR-199a maturation to link hypoxia to the Warburg effect and suggest a promising therapeutic strategy that targets miR-199a to interrupt cancerous aerobic glycolysis.	Authentic
Here, we report that expression of Notch3, a member of Notch family transmembrane receptors, was elevated in human cells during senescence activated by various senescence-inducing stimuli.	Authentic
A knockdown of MTDH mimicked the tumor-suppressive effects of miR-618 upregulation on OS cells.	Counterfeit
Neoepitopes, defined by mutated peptides inducing IFN-γ and/or TNF-α production without or only minimal reactivity to the wildtype sequences, were found for each individual patient.	Authentic
Therefore, the present study aimed to investigate the expression pattern of miR-137 and its functional significance in PTC.	Counterfeit
Furthermore, exogenous TGF-β1 and SDF-1 enhanced proliferation, colony formation, cell cycle progression, migration and invasion while decreased apoptosis of cells.	Counterfeit
Lipopolysaccharide (LPS) enforced the expression of GPR78.	Counterfeit
Toll-like receptors (TLRs) are also known to exert crucial functions in the immune response activation occurring in the pathogenesis of autoimmune diseases like SLE.	Counterfeit
The pathologic skeletal volumes for each technique (CT, HU > 600), NaF (SUV > 10) and FCH (SUV > 3.5) were developed and analyzed.	Authentic
With the aim of developing novel targets for RCC treatment, we explored the role of the circular RNA (circRNA) circ_001504 in the progression of RCC.	Counterfeit
Thereafter, cell viability, apoptosis and autophagy were assessed, respectively.	Counterfeit
The potential of targeted therapy with radiolabeled peptides has been reported in many conditions; peptide receptor radionuclide therapy (PRRT) is already part of Scandinavian guidelines for treating neuroendocrine tumors.	Authentic
SLC1A3 overexpressing and knock-down cell lines were constructed, and the cell viability was evaluated.	Counterfeit
We therefore investigated if hypoxia, TGF-β1 and the Notch ligand Jagged-1 alone induced morphological changes with corresponding EMT signatures in different epithelial breast cancer cell lines in vitro.	Authentic
We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer.	Authentic
The aim of this study is to explore the relationship between sense of disease uncertainty and family strength and mental resilience in guardians of children with inflammatory bowel disease (IBD).	Counterfeit
The targeting relationship between miR-206 and ANXA2 was verified with a dual-luciferase reporter assay.	Counterfeit
We found that frequent stromal TNC expression had a strong correlation with vessel density and tumor stage and endothelial GLUT-1 expression, when present, correlated with higher tumor stage.	Authentic
By utilizing a genome-wide CRISPR-Cas9 dropout screen in SCLC cells, we identified paired box protein 9 (PAX9) as an essential factor that is overexpressed in human malignant SCLC tumor samples and is transcriptionally driven by the BAP1/ASXL3/BRD4 epigenetic axis.	Authentic
Kindlin-2 siRNA inhibited cell spreading as well as the formation of actin fibrils and cell adhesions, but did not prevent the effect of PMA on lamellipodia formation.	Authentic

Renal cell carcinomas (RCCs) have a tendency to metastasize at an early stage, therefore, the patients frequently exhibit metastatic disease at the time of diagnosis.

Authentic

However, women with drug use disorders (DUD) are less likely to be reached by screening programs.

Authentic

These findings indicate that miR-26b inhibits PTGS2 to activate the MAPK pathway, so as to reduce inflammatory response and improve myocardial remodeling in mice with MI.

Counterfeit

The present study aimed to investigate the effect of HNP-1 on the matrix metalloproteinase (MMP)-2, -8 and -9 secretions of two oral squamous cell carcinoma (OSCC) cell lines (UT-SCC-43A and UT-SCC-43B).

Authentic

The results demonstrated that BCYRN1 was upregulated in cervical cancer tissues compared with normal tissues.

Counterfeit

The expression of BMP-2 released by SW480/oxaliplatin exosomes was 2.3-folds higher than that by SW480 exosomes.

Counterfeit

Here, we show that the next-generation B-Raf inhibitor PLX8394 blocks TGF-β signaling in ras-transformed metastatic epidermal keratinocytes (RT3 cells) harboring wild-type B-Raf and hyperactive Ras.

Authentic

Importantly, we found that sensitivity to MEK1/2 inhibition was ADAM17 dependent in vitro and in vivo.

Authentic

Besides, these regulatory effects were further explored with the determination of the autophagy- and apoptosis-related gene or proteins.

Counterfeit

To investigate the use of dual isocenters for VMAT planning in patients with lymph node positive synchronous bilateral breast cancer (BBC) compared to a single isocenter option.

Authentic

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of malignant pancreatic tumor.

Counterfeit

MicroRNA‑132 (miR‑132) has been shown to be dysregulated in certain types of human malignancies and is associated with tumor progression.

Counterfeit

These results demonstrated that PTEN gene silencing might promote proliferation of ASMCs and airway remodeling in a mouse model of allergic asthma.

Counterfeit

The complex 2 with both acidic and basic sites was investigated as heterogeneous catalyst, which reveals highly efficient catalytic property of the Knoevenagel condensation reaction.

Counterfeit

These factors stabilized mutant p53 protein which oftentimes contributed to exacerbated tumor phenotypes.

Authentic

In this research, we identified that HOXA7 performed its oncogenic characteristics through activating Snail.

Counterfeit

Two cell lines with the highest expressed PVT1 were selected, followed by transfection with a series of different mimic, inhibitor, or siRNA.

Counterfeit

The results also suggested that PAK2 may promote pancreatic cancer cell proliferation and migration in vitro through clone formation, MTT, wound healing and Transwell assays.

Counterfeit

We aimed to identify germline copy number variations (CNVs) contributing to HBOC susceptibility in the Finnish population.

Authentic

Here, we will discuss the potential of NK cells in CAR-based therapies focusing on the applications of CAR-NK cells in cancer therapy and beyond.

Authentic

Death from cSCC was observed in 516 non-OTRs (1.1%) and 40 OTRs (3.3%).

Authentic

Altogether, this present study highlights that the aqueous extract of Dendrobium officinale can suppress the neuronal apoptosis and enhance the expression of neurotrophic factors to protect neonatal rats against HIBD.

Counterfeit

The processing of the surgical specimen before the pathological examination was assessed from the operation records and pathology reports.

Authentic

Estimated 15-year recurrence-free survival (RFS) after surgery was 59·9% (95% CI 56·2-63·6); few recurrences occurred after the first 10 years of follow-up.

Authentic

Notably, miR-33 was predicted to target CROCC based on microarray-based analysis.

Counterfeit

From a total of 134 mCRPC patients who participated in the Activity and Safety of ODM-201 in Patients with Progressive Metastatic Castration-resistant Prostate Cancer clinical trial and received ODM-201, we retrospectively selected all those patients who had bone scan image data of sufficient quality to allow for both baseline and 12-wk follow-up BSI-assessments (n=47).

Authentic

SIGNIFICANCE: These findings uncover a novel function of CDK4 in lysosomal biology, which promotes cancer progression by activating mTORC1; targeting this function offers a new therapeutic strategy for cancer treatment.

Authentic

Also, the expression of collagen I and collagen II was observed.

Counterfeit

Finally, expression of key proteins in the apoptotic, Notch, and mTOR pathways was assessed.

Counterfeit

Recently emerging cancer immunotherapies combine the applications of therapeutics to disrupt the immunosuppressive conditions in tumor-bearing hosts.

Authentic

Then GEN administration alleviated inflammatory injury by increasing cell viability, while reducing apoptosis, and IL-6 and MCP-1 expression.

Counterfeit

Protein expression was estimated by western blot method.

Counterfeit

The diabetic control group showed higher cGMP production level transcription and protein levels of eNOS and DKK3 and lower production levels of AGEs and miR-328 than the diabetic ED and diabetic ED+NC groups.

Counterfeit

Herein, we identified a novel circRNA, circARFGEF2 (hsa_circ_0060665), which was upregulated in KRASG12D pancreatic ductal adenocarcinoma (PDAC) and positively associated with KRASG12D PDAC lymph node (LN) metastasis.

Authentic

MicroRNA transfection was conducted to reduce the expression level of miR-132.

Counterfeit

Moreover, the present study elucidated the MALAT1-miR-124-ERK/MAPK and Wnt/β-catenin signaling pathways in RB, which might provide a new approach for the treatment of RB.

Counterfeit

The adsorption/desorption behavior of the nanostructures is similar to that of the third type of isotherm series, which showed mesoporous behavior for the products.

Counterfeit

EZH2 and trimethylation of H3K27 (H3K27me3) protein expressions were detected using Western blotting.

Counterfeit

Region-dependent association of pBMDC was regulated by VEGF.

Authentic

The expression of phosphatidylinositol 3' -kinase (PI3K)/ protein kinase B (AKT) and c-Jun N-terminal kinase (JNK) was down-regulated by GEN (all P < .05) while reversed by HULC overexpression.

Counterfeit

Here, we identified increased expression of the adhesion molecule immunoglobulin superfamily member 9 (IGSF9) in tumor cells and tumor-infiltrating immune cells across multiple cancer types.

Authentic

The role of SOX12 in tumorigenesis of breast cancer is not well-understood.

Counterfeit

However, the underlying mechanism of MEG3 in glioma remains elusive.

Counterfeit

The proportion of patients receiving SPC increased gradually during the last year of life and was 77% in the last 3 months of life.

Authentic

Mechanistically, GAS5 functioned as competing endogenous RNA to repress miR-21, which controlled its down-stream target SOX5.

Counterfeit

Moreover, PTEN and caspase-3 were identified as the direct target genes of miR-29b.

Counterfeit

We aim to investigate the mechanism of miR-376b-5p/Sex-determining region Y-box 7 (SOX7)/Wnt/β-catenin axis in mice with ischemic brain injury.

Counterfeit

Finally, phosphorylated-LYRIC expression at serine 568 was significantly increased in metastatic tumors induced by DNP.

Counterfeit

To explore these changes, EVs from prostate, cutaneous T-cell lymphoma (CTCL), colon cancer cell lines, and control EVs from their noncancerous counterparts were isolated by differential ultracentrifugation and analyzed by nanoparticle tracking analysis (NTA), electron microscopy (EM), Western blotting, and liquid chromatography-mass spectrometry (LC-MS).

Authentic

The epilepsy rat model was induced by intraperitoneal injection of lithium chloride-pilocarpine.

Counterfeit

The mRNA and protein expressions of CDKN1A were remarkably down-regulated after MNX1-AS1 overexpression.

Counterfeit

Ectopic expression of miR-599 caused a significant reduction in the proliferation, migration and invasion of U-87MG Uppsala and U251 cells.

Counterfeit

Collectively, these findings identify CCR8 as a promising new target for tumor immunotherapy and provide a strong rationale for further development of this approach, either as a monotherapy or in combination with other immunotherapies.Significance: Inhibition of CCR8 represents a promising new cancer immunotherapy strategy that modulates tumor-resident regulatory T cells to enhance antitumor immunity and prolong patient survival.

Authentic

Here, we report that hypoxia potently induces the RNA-binding protein HuR to specifically bind primary miR-199a transcript to block miR-199a maturation in hepatocellular carcinoma (HCC) cells.

Authentic

In recent years, there has been a growing recognition that P values, albeit useful in reporting data analysis results, have often been misused or misinterpreted in biomedical research.

Authentic

We detected the geniposide (GEN) in HepG2 and Huh7 cell lines.

Counterfeit

Time-lapse microscopy was used to observe invasion in organoids from 25 surgically resected human PDAC samples in collagen I.

Authentic

However, the role of Meg3 in glioma cells remains largely unclear.

Counterfeit

Seven cases of totally or partially vanished thyroid lesions were identified from the archive of Department of Pathology, Fimlab Laboratories within 5 year period.

Authentic

To evaluate performances of published gene signatures for the assessment of urothelial carcinoma.

Authentic

At the 3-month follow-up, statistically significant differences between the two groups were found for overall quality of life (p = 0.006), fatigue (p = 0.023), sexual interest (p < 0.001) and urinary problems (p = 0.036).

Authentic

Myoferlin depletion blocked EGF-induced cell migration and epithelial-to-mesenchymal transition.

Authentic

Serum CA125STn concentration was significantly higher in EOC patients than in those with endometriosis (P < 0.001).

Authentic

For doses > 20% above and below mean (14% and 15% of patients, respectively) the risk of grade 3/4 HT was almost doubled (OR = 1.93, 95% CI, 1.21-3.10) and halved (OR = 0.52; 95% CI, 0.32-0.83), respectively.

Authentic

The increased expression of miR-663b was associated with advanced clinical stage and lymph node metastasis.

Counterfeit

Epithelial ovarian cancer (EOC) remains a major gynecological problem, with a poor 5-year-survival rate due to distant metastases.

Counterfeit

Similarly, the frequency of FoxP3+ CD4+ T cells (Tregs) was highly significantly elevated in tumor tissue compared to adjacent lung tissue.

Authentic

Additionally, the knockdown of H19 slowed down tumor growth, promoted apoptosis and upregulated miR-20b-5p expression but lowered the expressions of HIF-1α, PCNA and AXL in vivo.

Counterfeit

Biopsychosocial factors are important to take into account in order to achieve a holistic view of the situation.

Authentic

The cytotoxicity test revealed that BU-OE had marked cytotoxic activities against cancer cells, but no evident inhibitory effects on normal cells.

Counterfeit

Esophageal cancer is the eighth most prevalent malignancy in the world and China has a high incidence of esophageal cancer.

Counterfeit

Cell lines established from IGFBP-3KO:Myc tumors displayed more aggressive phenotypes in proliferation, invasion, and colony formation assays, relative to control Myc tumor cell lines.

Authentic

FGFR1 signaling suppresses progesterone receptor (PR) expression in vitro, and likewise, amplified cancers are frequently PR negative, identifying a potential biomarker for FGFR1 activity.

Authentic

Accordingly, the rate of PpIX synthesis was also accelerated by genistein pretreatment.

Authentic

Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) was utilized to detect ZFAS1 expression in tissue samples of HCC patients.

Counterfeit

The relationship among LINC00320, nuclear factor κB subunit 1 (NFKB1) and AQP9 was examined by RNA immunoprecipitation, dual-luciferase reporter gene, and chromatin immunoprecipitation assays.

Counterfeit

Angiogenesis is linked to tissue hypoxia through the activity of the oxygen-sensitive hypoxia-inducible factor 1α (HIF-1α).

Authentic

Functionally, LINC00470 bound to MYC in EC and that LINC00470 stimulated the binding of MYC to DNMT3a, and thus recruited DNMT3a through MYC to promote PTEN methylation.

Counterfeit

Up-regulation of miR-30b/30d attenuated oxidative stress, liver injury, and inflammatory reaction, and improved survival rate of FHF mice.

Counterfeit

SSTR2 expression did not vary between tumor sites but correlated within patients.

Authentic

These data reveal a novel mechanism of reprogramming of cancer energy metabolism in which HuR suppresses miR-199a maturation to link hypoxia to the Warburg effect and suggest a promising therapeutic strategy that targets miR-199a to interrupt cancerous aerobic glycolysis.

Authentic

Here, we report that expression of Notch3, a member of Notch family transmembrane receptors, was elevated in human cells during senescence activated by various senescence-inducing stimuli.

Authentic

A knockdown of MTDH mimicked the tumor-suppressive effects of miR-618 upregulation on OS cells.

Counterfeit

Neoepitopes, defined by mutated peptides inducing IFN-γ and/or TNF-α production without or only minimal reactivity to the wildtype sequences, were found for each individual patient.

Authentic

Therefore, the present study aimed to investigate the expression pattern of miR-137 and its functional significance in PTC.

Counterfeit

Furthermore, exogenous TGF-β1 and SDF-1 enhanced proliferation, colony formation, cell cycle progression, migration and invasion while decreased apoptosis of cells.

Counterfeit

Lipopolysaccharide (LPS) enforced the expression of GPR78.

Counterfeit

Toll-like receptors (TLRs) are also known to exert crucial functions in the immune response activation occurring in the pathogenesis of autoimmune diseases like SLE.

Counterfeit

The pathologic skeletal volumes for each technique (CT, HU > 600), NaF (SUV > 10) and FCH (SUV > 3.5) were developed and analyzed.

Authentic

With the aim of developing novel targets for RCC treatment, we explored the role of the circular RNA (circRNA) circ_001504 in the progression of RCC.

Counterfeit

Thereafter, cell viability, apoptosis and autophagy were assessed, respectively.

Counterfeit

The potential of targeted therapy with radiolabeled peptides has been reported in many conditions; peptide receptor radionuclide therapy (PRRT) is already part of Scandinavian guidelines for treating neuroendocrine tumors.

Authentic

SLC1A3 overexpressing and knock-down cell lines were constructed, and the cell viability was evaluated.

Counterfeit

We therefore investigated if hypoxia, TGF-β1 and the Notch ligand Jagged-1 alone induced morphological changes with corresponding EMT signatures in different epithelial breast cancer cell lines in vitro.

Authentic

We followed-up a cohort for 24 years investigating the association between missing teeth and the incidence of cancer with the hypothesis that dental chronic inflammation links to cancer.

Authentic

The aim of this study is to explore the relationship between sense of disease uncertainty and family strength and mental resilience in guardians of children with inflammatory bowel disease (IBD).

Counterfeit

The targeting relationship between miR-206 and ANXA2 was verified with a dual-luciferase reporter assay.

Counterfeit

We found that frequent stromal TNC expression had a strong correlation with vessel density and tumor stage and endothelial GLUT-1 expression, when present, correlated with higher tumor stage.

Authentic

By utilizing a genome-wide CRISPR-Cas9 dropout screen in SCLC cells, we identified paired box protein 9 (PAX9) as an essential factor that is overexpressed in human malignant SCLC tumor samples and is transcriptionally driven by the BAP1/ASXL3/BRD4 epigenetic axis.

Authentic

Kindlin-2 siRNA inhibited cell spreading as well as the formation of actin fibrils and cell adhesions, but did not prevent the effect of PMA on lamellipodia formation.

Authentic