Patent Number: 
Section: claims

1. A multi-axis sample preparation stage, comprising:a bulk sample holder configured to rotate a sample position about a first bulk axis parallel to the direction of the bulk sample holder and also rotate the sample position about a bulk flip axis that is perpendicular to the direction of the bulk sample holder; anda grid sample holder for holding a sample grid adjacent the bulk sample holder and configured to rotate the sample grid about a first grid axis parallel to the direction of the grid sample holder and a grid flip axis that is perpendicular to the direction of the grid sample holder. 2. The multi-axis sample preparation stage of claim 1, further comprising a thermal control system in contact with the bulk sample holder and the grid sample holder. 3. The multi-axis sample preparation stage of claim 2, wherein the thermal control system comprises a series of rollers configured to allow the multi-axis sample preparation stage to rotate in 360 degrees or more. 4. The multi-axis sample preparation stage of claim 2, wherein the thermal control system is configured to reduce the temperature of the grid sample holder and bulk sample holder to −150° C. or more. 5. The multi-axis sample preparation stage of claim 1, wherein the bulk sample holder and grid sample holder is configured to hold at least one of a grid, planchet, or tube. 6. The multi-axis sample preparation stage of claim 1, wherein the bulk sample holder or the grid sample holder is configured to rotate 360 degrees. 7. The multi-axis sample preparation stage of claim 1, further comprising a detector for performing S/TEM microscopy. 8. A dual beam system having a focused ion beam column and a scanning electron microscope column, comprising the multi-axis sample preparation stage of claim 1. 9. The dual beam system of claim 8, further comprising a thermal control system in contact with the bulk sample holder and the grid sample holder. 10. The dual beam system of claim 9, wherein the thermal control system comprises a series of rollers configured to allow the multi-axis sample preparation stage to rotate in 360 degrees or more. 11. The dual beam system of claim 9, wherein the thermal control system is configured to reduce the temperature of the grid sample holder and bulk sample holder to −150° C. or more. 12. The dual beam system of claim 8, wherein the bulk sample holder and grid sample holder is configured to hold at least one of a grid, planchet, or tube. 13. The dual beam system of claim 8, wherein the bulk sample holder or the grid sample holder is configured to rotate 360 degrees. 14. An in situ method of preparing a sample, comprising:providing the multi-axis sample preparation stage of claim 1;cutting a lamella from a sample stored in the bulk sample holder; andtransferring the lamella from the bulk sample holder to a grid on the grid sample holder. 15. The method of claim 14, wherein cutting a lamella comprises using a focused ion beam to cut a lamella from the region of interest of a bulk sample. 16. The method of claim 14, wherein a manipulator is attached to the lamella by soldering a tip of the manipulator to the lamella. 17. The method of claim 14, further comprising imaging the lamella. 18. The method of claim 14, further comprising rotating the lamella to determine if the lamella comprises vitreous or crystalline ice.