Patent Number: 048719137
Section: abstract

A signal processing method in autoradiography for determining base sequence of DNA or DNA fragment, employing groups of base-specific synthetic products which are complementary to the DNA or DNA fragment and a labeled with a radioactive element, said groups being resolved one-dimensionally in parallel relation to each other to form resolved rows on a support medium,. which comprises a process including: PA1 (1) determining on each of the resolved rows a scanning line for signal processing; PA1 (2) detecting on each of the resolved rows sampling points on said scanning line; and PA1 (3) comparing and identifying the positions of said sampling points on the scanning lines among the resolved rows to obtain locational information on guanine, ademine, thymine and cytosine; PA1 said process being applied to digital signals corresponding to an autoradiograph having the locational information on the radioactively labeled synthetic products, said digital signals being obtained by the use of a stimulable phosphor sheet or by the use of a radiosensitive material.