Patent Number: 
Section: claims

1. A method of providing intensity modulated radiation therapy to a target region wherein the tongue and groove effect is minimized, comprising:obtaining a multi-leaf collimator (MLC) sequence from an external leaf-sequencing algorithm; andmodifying the MLC sequence to compensate for the tongue and groove effect, wherein modifications are selected such that mechanical limitations of the MLC are not exceeded and at least one of the following is minimized:a non-weighted sum of the tongue and groove effects,a weighted sum of the tongue and groove effects using time-dependent weighting,a weighted sum of the tongue and groove effects using position-dependent weighting,a weighted sum of the tongue and groove effects using time- and position-dependent weighting,the tongue and groove effect distribution variance in spatial coordinates, orthe tongue and groove effect distribution variance in temporal coordinates. 2. The method of claim 1, wherein the step of modifying the MLC sequence includes adding compensating functions Ci(x) to leaf coordinates ai(x) and bi(x) for all leaf pairs i. 3. The method of claim 1, wherein the step of modifying the MLC sequence includes minimizing the weighted sum of the tongue and groove effects using time-dependent weighting, further comprising a target fluence that changes with time. 4. The method of claim 1, wherein the step of modifying the MLC sequence includes minimizing the weighted sum of the tongue and groove effects using time-dependent weighting and wherein the target region is in motion. 5. The method of claim 1, wherein the step of modifying the MLC sequence includes minimizing the weighted sum of the tongue and groove effects using position-dependent weighting and wherein the position-dependent weights are generated by minimum-leaf-gap-effect optimization. 6. The method of claim 1, wherein the step of modifying the MLC sequence includes minimizing the weighted sum of the tongue and groove effects using position-dependent weighting and wherein the position-dependent weights are generated by three dimensional organ arrangements in the target region. 7. The method of claim 1, wherein the step of modifying the MLC sequence includes minimizing the weighted sum of the tongue and groove effects using position-dependent weighting and wherein the position-dependent weights are generated by a rotational fluence. 8. The method of claim 1, wherein the step of modifying the MLC sequence further comprises selecting compensating functions such that the total treatment time is minimized. 9. The method of claim 1, wherein the step of modifying the MLC sequence further comprises selecting compensating functions such that changes to the original MLC sequence are minimized. 10. A computer readable medium including a computer program for controlling a multi-leaf collimator (MLC) to provide intensity modulated radiation therapy to a target region wherein the tongue and groove effect is minimized, comprising:software code executable on a computer to:obtain a multi-leaf collimator (MLC) sequence from an external leaf-sequencing algorithm; andmodify the MLC sequence to compensate for the tongue and groove effect, wherein modifications are selected such that mechanical limitations of the MLC are not exceeded and at least one of the following is minimized:a non-weighted sum of the tongue and groove effects,a weighted sum of the tongue and groove effects using time-dependent weighting,a weighted sum of the tongue and groove effects using position-dependent weighting,a weighted sum of the tongue and groove effects using time- and position-dependent weighting,the tongue and groove effect distribution variance in spatial coordinates, orthe tongue and groove effect distribution variance in temporal coordinates. 11. The computer readable medium of claim 10, wherein the software code executable on a computer to modify the MLC sequence adds compensating functions Ci(x) to leaf coordinates ai(x) and bi(x) for all leaf pairs i. 12. The computer readable medium of claim 10, wherein the software code executable on a computer to modify the MLC sequence selects compensating functions to minimize at least one of the total treatment time or changes to the original MLC sequence.