Patent Number: 
Section: claims

1. A method for synthesizing a functionalized resin for trapping an analyte, the method comprising:(a) providing a cationic exchange resin having carboxylate groups;(b) activating carboxylate groups of the cationic exchange resin with an activating agent; and(c) reacting activated carboxylate groups of the cationic exchange resin with a hydroxylamine salt in the presence of a base to produce the functionalized resin,wherein the activating agent comprises an alkyl ester of chloroformic acid. 2. The method of claim 1 wherein:the activating agent comprises methyl chloroformate. 3. The method of claim 1 wherein:the base comprises an amine. 4. The method of claim 3 wherein:the base is a tertiary amine. 5. The method of claim 3 wherein:the base is triethylamine. 6. The method of claim 1 wherein:the hydroxylamine salt s hydroxylamine hydrochloride. 7. The method of claim 1 wherein:step (b) is undertaken in the presence of a solvent for the activating agent. 8. The method of claim 7 wherein:the solvent comprises a halogenated alkane. 9. The method of claim 7 wherein:the solvent is dichloromethane. 10. The method of claim 7 further comprising:removing the solvent under vacuum. 11. The method of claim 1 wherein:the analyte is a radionuclide. 12. The method of claim 11 wherein:the radionuclide is 89Zr. 13. The method of claim 1 further comprising:(d) packing the functionalized resin into a cartridge. 14. The method of claim 1 wherein:the functionalized resin has a 89Zr elution efficiency of 40%-95% when eluting 89Zr from the functionalized resin with a phosphate eluent. 15. The method of claim 1 wherein:the functionalized resin has a 89Zr elution efficiency of 90%-95% when eluting 89Zr from the functionalized resin with a phosphate eluent. 16. The method of claim 1 wherein:the functionalized resin has a 89Zr trapping efficiency of 93%-97%. 17. The method of claim 1 wherein:the method is a one-pot synthesis method. 18. The method of claim 1 wherein:the functionalized resin is a hydroxamate functionalized resin. 19. A method for synthesizing a hydroxamate functionalized resin for trapping an analyte, the method comprising:(a) providing a cationic exchange resin having carboxylate groups;(b) activating carboxylate groups of the cationic exchange resin with an alkyl ester of a haloformic acid; and(c) reacting activated carboxylate groups of the cationic exchange resin with hydroxylamine hydrochloride in the presence of a tertiary amine to produce the hydroxamate functionalized resin. 20. A method for synthesizing a functionalized resin for trapping an analyte, the method comprising:(a) providing a cationic exchange resin having carboxylate groups;(b) activating carboxylate groups of the cationic exchange resin with an activating agent; and(c) reacting activated carboxylate groups of the cationic exchange resin with a hydroxylamine salt in the presence of a base to produce the functionalized resin,wherein the base comprises an amine. 21. The method of dam 20 wherein:the base is a tertiary amine. 22. The method of claim 20 wherein:the base is triethylamine.